Aliases & Classifications for Plagiocephaly

Summaries for Plagiocephaly

MalaCards based summary : Plagiocephaly is related to isolated plagiocephaly and muenke syndrome. An important gene associated with Plagiocephaly is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PI3K/AKT activation. The drug Salicylic acid has been mentioned in the context of this disorder. Affiliated tissues include bone, brain and heart, and related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

Wikipedia : 76 Plagiocephaly, also known as flat head syndrome, is a condition characterized by an asymmetrical... more...

Related Diseases for Plagiocephaly

Diseases related to Plagiocephaly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 isolated plagiocephaly 33.6 FGFR3 TWIST1
2 muenke syndrome 30.8 FGFR1 FGFR2 FGFR3 TWIST1
3 hemifacial hyperplasia 30.4 FGFR2 FGFR3
4 synostosis 30.3 FGFR1 FGFR2 FGFR3 TWIST1
5 strabismus 30.1 FGFR2 FGFR3 TWIST1
6 craniosynostosis 30.0 FGFR1 FGFR2 FGFR3 TWIST1
7 dysostosis 29.8 FGFR2 TWIST1
8 crouzon syndrome 29.5 FGFR1 FGFR2 FGFR3
9 apert syndrome 29.2 FGFR1 FGFR2 FGFR3 TWIST1
10 x-linked intellectual disability-plagiocephaly syndrome 12.4
11 lambdoid synostosis 11.5
12 mental retardation, x-linked, with craniofacial dysmorphism 11.2
13 faciocardiorenal syndrome 11.0
14 brachycephaly, deafness, cataract, microstomia, and mental retardation 11.0
15 49, xxxxx 11.0
16 iqsec2 11.0
17 torticollis 10.6
18 congenital torticollis 10.3
19 isolated brachycephaly 10.0 FGFR3 TWIST1
20 luteoma 10.0 FGFR2 FGFR3
21 beare-stevenson cutis gyrata syndrome 10.0 FGFR2 FGFR3
22 hypertropia 10.0 FGFR2 FGFR3
23 exophthalmos 10.0 FGFR2 FGFR3
24 chromosome 2q35 duplication syndrome 9.9 FGFR2 FGFR3
25 acanthosis nigricans 9.9 FGFR2 FGFR3
26 alagille syndrome 1 9.9
27 otitis media 9.9
28 sudden infant death syndrome 9.9
29 astigmatism 9.9
30 hemangioma 9.9
31 scoliosis 9.9
32 microphthalmia 9.9
33 heart disease 9.9
34 refractive error 9.9
35 hypertelorism 9.9 FGFR2 TWIST1
36 autosomal dominant disease 9.9 FGFR2 FGFR3
37 synovial chondromatosis 9.9 FGFR1 FGFR3
38 osteochondroma 9.9 FGFR1 FGFR3
39 giant cell glioblastoma 9.9 FGFR1 FGFR3
40 fibrolamellar carcinoma 9.9 FGFR1 FGFR2
41 antley-bixler syndrome 9.9 FGFR1 FGFR2
42 bone marrow cancer 9.8 FGFR1 FGFR3
43 orofacial cleft 9.8 FGFR1 FGFR2
44 gliosarcoma 9.7 FGFR1 FGFR3 TWIST1
45 tooth agenesis 9.7 FGFR1 FGFR2
46 osteoglophonic dysplasia 9.7 FGFR1 FGFR2 FGFR3
47 jackson-weiss syndrome 9.7 FGFR1 FGFR2 FGFR3
48 radioulnar synostosis 9.7 FGFR1 FGFR2 FGFR3
49 thanatophoric dysplasia, type i 9.7 FGFR1 FGFR2 FGFR3
50 hypochondroplasia 9.7 FGFR1 FGFR2 FGFR3

Graphical network of the top 20 diseases related to Plagiocephaly:



Diseases related to Plagiocephaly

Symptoms & Phenotypes for Plagiocephaly

GenomeRNAi Phenotypes related to Plagiocephaly according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.13 FGFR1 FGFR2 FGFR3
2 Decreased substrate adherent cell growth GR00193-A-2 8.8 FGFR2
3 Decreased substrate adherent cell growth GR00193-A-3 8.8 FGFR2 FGFR3

MGI Mouse Phenotypes related to Plagiocephaly:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.62 FGFR1 FGFR2 FGFR3 TWIST1
2 digestive/alimentary MP:0005381 9.56 FGFR1 FGFR2 FGFR3 TWIST1
3 hearing/vestibular/ear MP:0005377 9.33 FGFR1 FGFR2 FGFR3
4 limbs/digits/tail MP:0005371 9.26 FGFR1 FGFR2 FGFR3 TWIST1
5 skeleton MP:0005390 8.92 FGFR1 FGFR2 FGFR3 TWIST1

Drugs & Therapeutics for Plagiocephaly

Drugs for Plagiocephaly (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Investigating the Effectiveness of Control Frequency on and Deformational Plagiocephaly Unknown status NCT02607969 Not Applicable
2 Investigating the Effectiveness of Mobilization on Congenital Muscular Torticollis and Deformational Plagiocephaly Unknown status NCT02403011 Not Applicable
3 Postural Assessment in Plagiocephaly Completed NCT01989286
4 Efficacy of Pediatric Manual Therapy in the Positional Plagiocephaly Recruiting NCT03659032 Not Applicable
5 Premie Pouch to Manage Deformational Plagiocephaly in Very Low Birth Weight Infants Active, not recruiting NCT03184441 Not Applicable
6 Newborn Head Molding and Later Asymmetries Active, not recruiting NCT02283229 Not Applicable
7 Brain Characteristics Noted Prior to and Following Treatment Active, not recruiting NCT02392195
8 Osteopathic Approach Into Neonatology Ward: the NE-O Model Available NCT01902563
9 Effect of Usage Time of Helmet in Babies With Deformational Plagiocephaly Not yet recruiting NCT03430739
10 Cranial Orthotic Device Versus Repositioning Techniques for the Management of Plagiocephaly: the CRANIO Randomized Trial Not yet recruiting NCT02370901 Not Applicable
11 Preventive Osteopathic Treatment of Plagiocephaly Not yet recruiting NCT03780920 Not Applicable
12 Cranial Cup Use for the Prevention of Positional Head Shape Deformity in the NICU Terminated NCT01218087 Not Applicable
13 Hanger Helmet Study Withdrawn NCT02561728 Not Applicable

Search NIH Clinical Center for Plagiocephaly

Genetic Tests for Plagiocephaly

Genetic tests related to Plagiocephaly:

# Genetic test Affiliating Genes
1 Plagiocephaly 29

Anatomical Context for Plagiocephaly

MalaCards organs/tissues related to Plagiocephaly:

41
Bone, Brain, Heart, Testes, Eye, Lung, Bone Marrow

Publications for Plagiocephaly

Articles related to Plagiocephaly:

(show top 50) (show all 410)
# Title Authors Year
1
Head orthosis therapy in positional plagiocephaly: longitudinal 3D-investigation of long-term outcomes, compared with untreated infants and with a control group. ( 29617743 )
2018
2
A Clinical Photographic Method to Evaluate the Need for Helmet Therapy in Deformational Plagiocephaly. ( 29194259 )
2018
3
Effect of head orthoses on skull deformities in positional plagiocephaly: Evaluation of a 3-dimensional approach. ( 29680682 )
2018
4
Preventing "Flat-headed" Babies: A Commentary on "Impact of Parent Practices of Infant Positioning on Head Orientation Profile and Development of Positional Plagiocephaly in Healthy Term Infants". ( 29372872 )
2018
5
Analysis of the correlation between deformational plagiocephaly and neurodevelopment delay: Methodological issues. ( 29229424 )
2018
6
A New Operative One-Wing Technique to Correct Fronto-Orbital Region in Unilateral Nonsyndromic Plagiocephaly. ( 29065042 )
2018
7
Analysis of the correlation between deformational plagiocephaly and neurodevelopment delay: Methodological issues. ( 29246736 )
2018
8
Anterior Unilateral Plagiocephaly in Patient with Alagille Syndrome: Case Report. ( 29530693 )
2018
9
Quantitative analysis of cranial-orbital changes in infants with anterior synostotic plagiocephaly. ( 29761256 )
2018
10
Facial asymmetry correction with moulded helmet therapy in infants with deformational skull base plagiocephaly. ( 29221913 )
2018
11
Evaluation of positional plagiocephaly: Conventional anthropometric measurement versus laser scanning method. ( 29137851 )
2018
12
Assessing calvarial vault constriction associated with helmet therapy in deformational plagiocephaly. ( 29749885 )
2018
13
Three-dimensional study of 31 cases of synostotic anterior plagiocephaly before and after surgical management the Lille protocol. ( 29661661 )
2018
14
Craniofacial Distraction in the Management of Anterior Plagiocephaly: A Novel Idea and a Systematic Review of the Literature. ( 29408824 )
2018
15
Analysis of the correlation between deformational plagiocephaly and neurodevelopmental delay. ( 28958569 )
2018
16
Use of black-bone MRI in the diagnosis of the patients with posterior plagiocephaly. ( 29594536 )
2018
17
Description of Mandibular Improvements in a Series of Infants With Congenital Muscular Torticollis and Deformational Plagiocephaly Treated With Physical Therapy. ( 29989836 )
2018
18
Prevalence and characteristics of positional plagiocephaly in healthy full-term infants at 8-12 weeks of life. ( 30030600 )
2018
19
Integrating new knowledge into practice: An evaluation study on a continuing education for Swedish child health nurses on non-synostotic plagiocephaly. ( 30062027 )
2018
20
Deformational plagiocephaly: The case for an evolutionary mismatch. ( 30151193 )
2018
21
Early Surgical Treatment in Anterior Synostotic Plagiocephaly: Is This the Best Choice? ( 30320675 )
2018
22
Parents' Perspectives and Clinical Effectiveness of Cranial-Molding Orthoses in Infants With Plagiocephaly. ( 30404423 )
2018
23
The functional manual therapy intervention in infants with nonsynostotic plagiocephaly: a pilot study. ( 29072040 )
2017
24
Head Orthosis Therapy in Positional Plagiocephaly: Influence of Age and Severity of Asymmetry on Effect and Duration of Therapy. ( 28746283 )
2017
25
Plagiocephaly Severity Scale to Aid in Clinical Treatment Recommendations. ( 28468155 )
2017
26
Time to revisit tummy time: A commentary on plagiocephaly and development. ( 29479204 )
2017
27
Factors influencing outcomes of the treatment of positional plagiocephaly in infants: a 7-year experience. ( 28084921 )
2017
28
Discussion: Head Orthosis Therapy in Positional Plagiocephaly: Influence of Age and Severity of Asymmetry on Effect and Duration of Therapy. ( 28746284 )
2017
29
Six month-old infants with deformational plagiocephaly do not differ from unaffected infants with respect to vocal control. ( 29106864 )
2017
30
The Role of Age and Initial Deformation on Final Cranial Asymmetry in Infants with Plagiocephaly Treated with Helmet Therapy. ( 28850946 )
2017
31
Unicoronal Craniosynostosis and Plagiocephaly Correction with Fronto-orbital Bone Remodeling and Advancement. ( 28713746 )
2017
32
Accuracy of measurements used to quantify cranial asymmetry inA deformational plagiocephaly. ( 28615136 )
2017
33
Does shape affect function? Articulatory skills in babbling of infants with deformational plagiocephaly. ( 28875353 )
2017
34
Comparison of endocranial morphology according to age in one-piece fronto-orbital advancement using a distraction in craniosynostotic plagiocephaly. ( 28724507 )
2017
35
Deformational plagiocephaly in normal infants: a systematic review of causes and hypotheses. ( 28104626 )
2017
36
The health belief model and factors associated with adherence to treatment recommendations for positional plagiocephaly. ( 28084919 )
2017
37
Relationship between starting age of cranial-remolding-orthosis therapy and effectiveness of treatment in children with deformational plagiocephaly. ( 28484866 )
2017
38
Impact of Parent Practices of Infant Positioning on Head Orientation Profile and Development of Positional Plagiocephaly in Healthy Term Infants. ( 28375778 )
2017
39
Deformational Plagiocephaly: A Review. ( 29394478 )
2017
40
Positional plagiocephaly is associated with sternocleidomastoid muscle activation in healthy term infants. ( 28236068 )
2017
41
Plagiocephaly and Developmental Delay: A Systematic Review. ( 28009719 )
2017
42
Effects of manual therapy on treatment duration and motor development in infants with severe nonsynostotic plagiocephaly: a randomised controlled pilot study. ( 27465676 )
2016
43
Assessment of Deformational Plagiocephaly Severity and Neonatal Developmental Delay. ( 28005729 )
2016
44
Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Management of Patients With Positional Plagiocephaly: Executive Summary. ( 27759671 )
2016
45
Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Role of Cranial Molding Orthosis (Helmet) Therapy for Patients With Positional Plagiocephaly. ( 27759675 )
2016
46
Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Management of Patients With Positional Plagiocephaly: The Role of Physical Therapy. ( 27759674 )
2016
47
Effect of fronto-orbital advancement on astigmatism in patients with anterior plagiocephaly. ( 27567360 )
2016
48
Use of external orthotic helmet therapy in positional plagiocephaly. ( 26947339 )
2016
49
Quantitative analysis of craniofacial dysmorphology in infants with anterior synostotic plagiocephaly. ( 27541866 )
2016
50
Review of 5 Articles of "Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Patients With Positional Plagiocephaly" Articles in Neurosurgery 79: E623-E633, 2016. ( 28045817 )
2016

Variations for Plagiocephaly

Expression for Plagiocephaly

Search GEO for disease gene expression data for Plagiocephaly.

Pathways for Plagiocephaly

Pathways related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13 FGFR1 FGFR2 FGFR3 TWIST1
2
Show member pathways
12.8 FGFR1 FGFR2 FGFR3
3
Show member pathways
12.76 FGFR1 FGFR2 FGFR3
4
Show member pathways
12.74 FGFR1 FGFR2 FGFR3
5
Show member pathways
12.7 FGFR1 FGFR2 FGFR3
6
Show member pathways
12.69 FGFR1 FGFR2 FGFR3
7
Show member pathways
12.59 FGFR1 FGFR2 FGFR3
8
Show member pathways
12.57 FGFR1 FGFR2 FGFR3
9 12.56 FGFR1 FGFR2 FGFR3
10
Show member pathways
12.5 FGFR1 FGFR2 FGFR3
11 12.49 FGFR1 FGFR2 FGFR3
12
Show member pathways
12.46 FGFR1 FGFR2 FGFR3
13
Show member pathways
12.45 FGFR1 FGFR2 FGFR3
14
Show member pathways
12.42 FGFR1 FGFR2 FGFR3
15 12.36 FGFR1 FGFR2 FGFR3
16
Show member pathways
12.31 FGFR1 FGFR2 FGFR3
17
Show member pathways
12.22 FGFR1 FGFR2 FGFR3
18
Show member pathways
12.16 FGFR1 FGFR2 FGFR3
19
Show member pathways
12.15 FGFR1 FGFR2 FGFR3
20
Show member pathways
12.13 FGFR1 FGFR2 FGFR3
21
Show member pathways
12.1 FGFR1 FGFR2 FGFR3
22
Show member pathways
12.09 FGFR1 FGFR2 FGFR3
23
Show member pathways
12 FGFR1 FGFR2 FGFR3
24
Show member pathways
11.97 FGFR1 FGFR2 FGFR3
25
Show member pathways
11.92 FGFR1 FGFR2 FGFR3
26
Show member pathways
11.91 FGFR1 FGFR2 FGFR3
27 11.83 FGFR1 FGFR2 FGFR3
28
Show member pathways
11.83 FGFR1 FGFR2 FGFR3
29
Show member pathways
11.81 FGFR1 FGFR2 FGFR3
30 11.75 FGFR1 FGFR2 FGFR3
31 11.69 FGFR1 FGFR2 FGFR3
32 11.57 FGFR1 FGFR3
33 11.48 FGFR1 FGFR3
34 11.46 FGFR1 FGFR2 FGFR3
35 11.45 FGFR1 FGFR2 FGFR3
36 11.31 FGFR1 FGFR2
37 11.25 FGFR1 FGFR2 FGFR3
38 11.12 FGFR1 FGFR2 FGFR3
39 10.99 FGFR1 FGFR2 FGFR3
40 10.93 FGFR1 FGFR2 FGFR3 TWIST1
41 10.76 FGFR1 FGFR2 FGFR3
42 10.76 FGFR1 FGFR2 FGFR3
43 10.75 FGFR1 FGFR2 FGFR3

GO Terms for Plagiocephaly

Cellular components related to Plagiocephaly according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.13 FGFR1 FGFR2 FGFR3
2 receptor complex GO:0043235 8.8 FGFR1 FGFR2 FGFR3

Biological processes related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.89 FGFR1 FGFR2 FGFR3 TWIST1
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.87 FGFR1 FGFR2 TWIST1
3 phosphorylation GO:0016310 9.86 FGFR1 FGFR2 FGFR3
4 protein phosphorylation GO:0006468 9.85 FGFR1 FGFR2 FGFR3
5 positive regulation of cell proliferation GO:0008284 9.85 FGFR1 FGFR2 FGFR3
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.78 FGFR1 FGFR2 FGFR3
7 MAPK cascade GO:0000165 9.77 FGFR1 FGFR2 FGFR3
8 in utero embryonic development GO:0001701 9.76 FGFR1 FGFR2 TWIST1
9 peptidyl-tyrosine phosphorylation GO:0018108 9.74 FGFR1 FGFR2 FGFR3
10 protein autophosphorylation GO:0046777 9.73 FGFR1 FGFR2 FGFR3
11 positive regulation of protein kinase B signaling GO:0051897 9.72 FGFR1 FGFR2 FGFR3
12 negative regulation of apoptotic process GO:0043066 9.71 FGFR1 FGFR2 FGFR3 TWIST1
13 skeletal system development GO:0001501 9.69 FGFR1 FGFR3
14 neuron migration GO:0001764 9.69 FGFR1 TWIST1
15 positive regulation of MAPK cascade GO:0043410 9.69 FGFR1 FGFR2 FGFR3
16 lung development GO:0030324 9.68 FGFR1 FGFR2
17 inner ear morphogenesis GO:0042472 9.67 FGFR1 FGFR2
18 positive regulation of epithelial cell proliferation GO:0050679 9.67 FGFR2 TWIST1
19 embryonic limb morphogenesis GO:0030326 9.67 FGFR1 TWIST1
20 positive regulation of cell cycle GO:0045787 9.66 FGFR1 FGFR2
21 bone development GO:0060348 9.66 FGFR2 TWIST1
22 skeletal system morphogenesis GO:0048705 9.65 FGFR1 FGFR2
23 ureteric bud development GO:0001657 9.65 FGFR1 FGFR2
24 bone mineralization GO:0030282 9.65 FGFR2 FGFR3
25 chondrocyte differentiation GO:0002062 9.64 FGFR1 FGFR3
26 positive regulation of cardiac muscle cell proliferation GO:0060045 9.64 FGFR1 FGFR2
27 midbrain development GO:0030901 9.63 FGFR1 FGFR2
28 embryonic cranial skeleton morphogenesis GO:0048701 9.63 FGFR2 TWIST1
29 negative regulation of signal transduction GO:0009968 9.63 FGFR1 FGFR2 FGFR3
30 bone morphogenesis GO:0060349 9.62 FGFR2 FGFR3
31 odontogenesis GO:0042476 9.62 FGFR2 TWIST1
32 positive regulation of mesenchymal cell proliferation GO:0002053 9.61 FGFR1 FGFR2
33 phosphatidylinositol phosphorylation GO:0046854 9.61 FGFR1 FGFR2 FGFR3
34 branching involved in salivary gland morphogenesis GO:0060445 9.58 FGFR1 FGFR2
35 mesenchymal cell differentiation GO:0048762 9.54 FGFR1 FGFR2
36 outer ear morphogenesis GO:0042473 9.52 FGFR1 TWIST1
37 fibroblast growth factor receptor signaling pathway GO:0008543 9.5 FGFR1 FGFR2 FGFR3
38 lung-associated mesenchyme development GO:0060484 9.49 FGFR1 FGFR2
39 endochondral bone growth GO:0003416 9.48 FGFR2 FGFR3
40 orbitofrontal cortex development GO:0021769 9.37 FGFR1 FGFR2
41 ventricular zone neuroblast division GO:0021847 9.26 FGFR1 FGFR2
42 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035607 9.16 FGFR1 FGFR2
43 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.13 FGFR1 FGFR2 FGFR3
44 positive regulation of phospholipase activity GO:0010518 8.8 FGFR1 FGFR2 FGFR3

Molecular functions related to Plagiocephaly according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.69 FGFR1 FGFR2 TWIST1
2 kinase activity GO:0016301 9.67 FGFR1 FGFR2 FGFR3
3 protein kinase activity GO:0004672 9.65 FGFR1 FGFR2 FGFR3
4 nucleotide binding GO:0000166 9.63 FGFR1 FGFR2 FGFR3
5 transmembrane signaling receptor activity GO:0004888 9.61 FGFR1 FGFR2 FGFR3
6 protein tyrosine kinase activity GO:0004713 9.58 FGFR1 FGFR2 FGFR3
7 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 FGFR1 FGFR2 FGFR3
8 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.5 FGFR1 FGFR2 FGFR3
9 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 FGFR1 FGFR2 FGFR3
10 1-phosphatidylinositol-3-kinase activity GO:0016303 9.33 FGFR1 FGFR2 FGFR3
11 fibroblast growth factor binding GO:0017134 9.13 FGFR1 FGFR2 FGFR3
12 fibroblast growth factor-activated receptor activity GO:0005007 8.8 FGFR1 FGFR2 FGFR3

Sources for Plagiocephaly

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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