MCID: PLG002
MIFTS: 58

Plague

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Plague

MalaCards integrated aliases for Plague:

Name: Plague 12 74 58 42 3 15 71 32
Yersiniosis 58 3
Yersinia Infections 71

Characteristics:

Orphanet epidemiological data:

58
plague
Prevalence: 1-9/100000 (Europe); Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Plague

MedlinePlus : 42 Plague is an infection caused by the bacterium Yersinia pestis. The bacteria are found mainly in rats and in the fleas that feed on them. People and other animals can get plague from rat or flea bites. In the past, plague destroyed entire civilizations. Today plague is uncommon, due to better living conditions and antibiotics. There are three forms of plague: Bubonic plague causes the tonsils, adenoids, spleen, and thymus to become inflamed. Symptoms include fever, aches, chills, and tender lymph glands. In septicemic plague, bacteria multiply in the blood. It causes fever, chills, shock, and bleeding under the skin or other organs. Pneumonic plague is the most serious form. Bacteria enter the lungs and cause pneumonia. People with the infection can spread this form to others. This type could be a bioterror agent. Lab tests can diagnose plague. Treatment is a strong antibiotic. There is no vaccine.

MalaCards based summary : Plague, also known as yersiniosis, is related to bacterial infectious disease and septicemic plague, and has symptoms including fever and pruritus. An important gene associated with Plague is CCR5 (C-C Motif Chemokine Receptor 5), and among its related pathways/superpathways are Human cytomegalovirus infection and T cell receptor signaling pathway. The drugs Streptomycin and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, vasculature and lungs, and related phenotypes are fatigue and fever

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, located in lymph node, located in vasculature or located in lungs, has material basis in Yersinia pestis, which is transmitted by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted by air, transmitted by direct contact or transmitted by ingestion of contaminated undercooked food.

CDC : 3 Y. enterolitica are the most common species causing human enteric (intestinal) yersiniosis. Pigs are the major animal reservoir for the few strains of Y. enterocolitica that cause human illness, but rodents, rabbits, sheep, cattle, horses, dogs, and cats also can carry strains that cause human illness.

Wikipedia : 74 Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever,... more...

Related Diseases for Plague

Diseases related to Plague via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 bacterial infectious disease 30.3 MYD88 H2AC18 FPR1 CD86
2 septicemic plague 30.1 SULT1A2 PLG
3 pneumonic plague 30.0 SULT1A2 PLG HMSD
4 rubeosis iridis 10.4 PLG FPR1
5 lymphocytic choriomeningitis 10.4 MYD88 DDX58 CD86
6 pulmonary vein stenosis 10.3 TYMP PECAM1
7 coccidiosis 10.3 MYD88 H2AC18 CCR5
8 herpangina 10.3 MYD88 H2AC18 DDX58
9 pulmonary artery leiomyosarcoma 10.3 PLG PECAM1
10 reactive arthritis 10.3
11 kidney cortex necrosis 10.3 PLG H2AC18
12 hypotrichosis 1 10.3 H2AC18 CD86 CCR5
13 erythema nodosum 10.3
14 parasitic protozoa infectious disease 10.3 MYD88 H2AC18 CD86 CCR5
15 primary bacterial infectious disease 10.3 MYD88 H2AC18 CD86 CCR5
16 lymphadenitis 10.3
17 arteriosclerosis 10.3 SELE RHOA PECAM1 CCR5
18 viral infectious disease 10.2 MYD88 H2AC18 DDX58 CCR5
19 granulomatosis with polyangiitis 10.2 SELE CD86 CCR5
20 trypanosomiasis 10.2 SELE MYD88 H2AC18
21 mesenteric lymphadenitis 10.2
22 appendicitis 10.2
23 ileitis 10.2
24 salmonellosis 10.2
25 brucellosis 10.2
26 enterocolitis 10.1
27 gastroenteritis 10.1
28 bubonic plague 10.1 SULT1A2 PLG HMSD CCR5 ACP1
29 lymphoma, non-hodgkin, familial 10.1 RHOA PECAM1 MYD88 H2AC18 CD86
30 acquired immunodeficiency syndrome 10.1 SELE PECAM1 CCR5
31 diarrhea 10.1
32 dysentery 10.1
33 shigellosis 10.1
34 tularemia 10.1
35 cardiovascular system disease 10.0 SELE PLG PECAM1 H2AC18
36 lipoprotein quantitative trait locus 10.0 SELE PLG PECAM1 MYD88 H2AC18
37 erythema multiforme 10.0
38 listeriosis 10.0
39 crohn's disease 10.0
40 body mass index quantitative trait locus 11 10.0 SELE RHOA PTS MGAT1 H2AC18 ACP1
41 pfeiffer syndrome 9.9
42 hemosiderosis 9.9
43 hepatitis a 9.9
44 uveitis 9.9
45 campylobacteriosis 9.9
46 panniculitis 9.9
47 hemoglobinopathy 9.9
48 acute pancreatitis 9.9
49 myocarditis 9.9
50 peritonitis 9.9

Graphical network of the top 20 diseases related to Plague:



Diseases related to Plague

Symptoms & Phenotypes for Plague

Human phenotypes related to Plague:

58 31 (show top 50) (show all 53)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 lymphadenitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002840
4 splenomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0001744
5 hepatomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0002240
6 dry skin 58 31 frequent (33%) Frequent (79-30%) HP:0000958
7 anxiety 58 31 frequent (33%) Frequent (79-30%) HP:0000739
8 skin ulcer 58 31 frequent (33%) Frequent (79-30%) HP:0200042
9 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
10 chest pain 58 31 frequent (33%) Frequent (79-30%) HP:0100749
11 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
12 abnormal blistering of the skin 58 31 frequent (33%) Frequent (79-30%) HP:0008066
13 tachycardia 58 31 frequent (33%) Frequent (79-30%) HP:0001649
14 chills 58 31 frequent (33%) Frequent (79-30%) HP:0025143
15 conjunctival hyperemia 58 31 frequent (33%) Frequent (79-30%) HP:0030953
16 delirium 58 31 frequent (33%) Frequent (79-30%) HP:0031258
17 bacteremia 58 31 frequent (33%) Frequent (79-30%) HP:0031864
18 depressivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0000716
19 hypotension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002615
20 hearing impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000365
21 vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002013
22 slurred speech 58 31 occasional (7.5%) Occasional (29-5%) HP:0001350
23 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
24 arthralgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002829
25 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
26 skin rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0000988
27 sepsis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100806
28 hematemesis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002248
29 abnormality of the elbow 58 31 occasional (7.5%) Occasional (29-5%) HP:0009811
30 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
31 respiratory distress 58 31 occasional (7.5%) Occasional (29-5%) HP:0002098
32 glossitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000206
33 unsteady gait 58 31 occasional (7.5%) Occasional (29-5%) HP:0002317
34 edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0000969
35 mydriasis 58 31 occasional (7.5%) Occasional (29-5%) HP:0011499
36 erythema nodosum 58 31 occasional (7.5%) Occasional (29-5%) HP:0012219
37 enterocolitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004387
38 acute infectious pneumonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0011949
39 bloody diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0025085
40 enlarged mesenteric lymph node 58 31 occasional (7.5%) Occasional (29-5%) HP:0025043
41 chapped lip 58 31 occasional (7.5%) Occasional (29-5%) HP:0040181
42 muscle weakness 58 31 very rare (1%) Very rare (<4-1%) HP:0001324
43 arthritis 58 31 very rare (1%) Very rare (<4-1%) HP:0001369
44 endocarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0100584
45 meningitis 58 31 very rare (1%) Very rare (<4-1%) HP:0001287
46 inflammatory abnormality of the eye 58 31 very rare (1%) Very rare (<4-1%) HP:0100533
47 pharyngitis 58 31 very rare (1%) Very rare (<4-1%) HP:0025439
48 reduced consciousness/confusion 58 Frequent (79-30%)
49 inflammation of the large intestine 58 Occasional (29-5%)
50 arrhythmia 58 Occasional (29-5%)

UMLS symptoms related to Plague:


fever, pruritus

MGI Mouse Phenotypes related to Plague:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 ACP1 CCR5 CD86 CDC25C DDX58 FPR1
2 cardiovascular system MP:0005385 10.1 ACP1 CCR5 CD83 INVS MGAT1 MYD88
3 hematopoietic system MP:0005397 10.03 CCR5 CD83 CD86 DDX58 FPR1 INVS
4 homeostasis/metabolism MP:0005376 10 ACP1 CCR5 CD86 DDX58 FPR1 INVS
5 digestive/alimentary MP:0005381 9.92 CCR5 CDC25C DDX58 INVS MYD88 PECAM1
6 immune system MP:0005387 9.77 ACP1 CCR5 CD83 CD86 DDX58 FPR1
7 liver/biliary system MP:0005370 9.17 CCR5 DDX58 INVS MYD88 PECAM1 PLG

Drugs & Therapeutics for Plague

Drugs for Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Streptomycin Approved, Vet_approved Phase 3 57-92-1 19649
2
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
3 Gentamicins Phase 2, Phase 3
4 Anti-Infective Agents Phase 3
5 Anti-Bacterial Agents Phase 3
6 Cytochrome P-450 Enzyme Inhibitors Phase 3
7
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
8 Immunologic Factors Phase 2
9 Vaccines Phase 2
10
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
11 Gastrointestinal Agents Phase 1
12 Antacids Phase 1
13 Adjuvants, Immunologic Phase 1
14 Anti-Ulcer Agents Phase 1
15 Pharmaceutical Solutions Phase 1
16
Vitamin D3 Approved, Nutraceutical 67-97-0 6221 5280795
17
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
18 Trace Elements
19 Micronutrients
20 Vitamins
21 Hormones
22 Calcium, Dietary
23 Calciferol
24 Nutrients
25
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Gentamicin Versus Streptomycin for the Treatment of Naturally Occurring Human Plague and Evaluation of Rapid Diagnostic Test Kits for Yersinia Pestis Completed NCT00128466 Phase 2, Phase 3 gentamicin;streptomycin
2 An Open-label, Randomised, Non-inferiority Trial of the Efficacy and Safety of Ciprofloxacin Versus Streptomycin + Ciprofloxacin in the Treatment of Bubonic Plague Recruiting NCT04110340 Phase 3 Ciprofloxacin;Streptomycin
3 A Randomized, Non-inferiority, Active Controlled Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin Versus Doxycycline in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline
4 Immunogenicity and Safety of Subunit Plague Vaccine Comprised by Fraction 1 Capsule (F1) and Virulence-Associated (V) Antigens: A Random Phase 2a Clinical Trial Completed NCT02596308 Phase 2
5 A Phase 2b Randomized, Single-Blinded Study to Evaluate the Safety and Immunogenicity of 80 µg Recombinant Plague Vaccine (rF1V) With and Without Adjuvant at Two Vaccination Schedules in Healthy Adult Volunteers Completed NCT01122784 Phase 2
6 A Phase 2 (a), Dose-Blinded, Block-Randomized, Dose and Schedule Selection Study to Evaluate the Immunogenicity and Safety of the Recombinant Plague Vaccine rF1V in Healthy Volunteers Completed NCT00332956 Phase 2
7 A Phase 1b, Multi-Centre, Parallel Group, Single Blind Study to Evaluate the Safety, Tolerability and Immunogenicity of a Recombinant Plague Vaccine (rF1 and rV Antigens) in Healthy Subjects Completed NCT00246467 Phase 1
8 A Phase 1, Open-Label, Dose-Escalating Study to Evaluate the Safety, Tolerability and Immunogenicity of the Recombinant Plague Vaccine rF1V in Healthy Volunteers Completed NCT00097396 Phase 1
9 A Phase I Safety and Immunogenicity Dose Escalation Trial of Plague Vaccine, Flagellin/F1/V, In Healthy Adult Volunteers Completed NCT01381744 Phase 1
10 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies. What Does the Patient Suffer From When the Appendix Proves to be Healthy? Completed NCT03349814
11 Evaluation of Gingival Crevicular Fluid Levels of LL-37 and Serum Vitamin D3 Levels in Smoker and Non-Smoker Patients With Chronic Periodontitis Completed NCT03923218
12 Point of Care Diagnostic to Identify the Causative Agent of the Plague Recruiting NCT04688996
13 Point of Care Diagnostic to Identify the Causative Agent of the Plague Recruiting NCT04562012
14 The Dental Care Revolution: Health Education Using AI or Humanized Counseling on Plague Control and Periodontal Treatment Outcome in Patients With Periodontal Disease - Pilot Study: A Randomized Controlled Trial Recruiting NCT04567030

Search NIH Clinical Center for Plague

Genetic Tests for Plague

Anatomical Context for Plague

The Foundational Model of Anatomy Ontology organs/tissues related to Plague:

19
Lymph Node, Vasculature, Lungs

MalaCards organs/tissues related to Plague:

40
Lymph Node, Spleen, Thymus, Skin, Eye, Neutrophil, Kidney

Publications for Plague

Articles related to Plague:

(show top 50) (show all 9977)
# Title Authors PMID Year
1
The Three-Plague Nature of COVID-19 Pandemic: Implications for Women and Children and Exposure to Violence. 61 42
33464031 2021
2
Platelets-Disarmed guardians in the fight against the plague. 42 61
33467844 2020
3
No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19. 42 61
33344044 2020
4
Systematic analysis, identification, and use of CRISPR/Cas13a-associated crRNAs for sensitive and specific detection of the lcrV gene of Yersinia pestis. 61
33360431 2021
5
A Differential Approach for Gaze Estimation. 61
31804927 2021
6
Virulence genotyping and antimicrobial resistance profiles of Yersinia enterocolitica isolated from meat and meat products in Egypt. 61
32996992 2021
7
Dermatofibrosarcoma protuberans of the breast: A case study. 61
33604040 2021
8
The Manchurian Plague and COVID-19: China, the United States, and the "Sick Man," Then and Now. 61
33476233 2021
9
Single-dose intranasal subunit vaccine rapidly clears secondary sepsis in a high-dose pneumonic plague infection. 61
33531196 2021
10
The delayed effect of cooling reinforced the NAO-plague connection in pre-industrial Europe. 61
33129517 2021
11
Molecular and Genetic Mechanisms That Mediate Transmission of Yersinia pestis by Fleas. 61
33546271 2021
12
Crucial Role of Juvenile Hormone Receptor Components Methoprene-Tolerant and Taiman in Sexual Maturation of Adult Male Desert Locusts. 61
33572050 2021
13
Crayfish (Cherax quadricarinatus) susceptibility to acute hepatopancreatic necrosis disease (AHPND). 61
33596436 2021
14
The Effects of Topographic Micropatterning on Endothelial Colony-Forming Cells. 61
32600119 2021
15
Yersiniosis in New Zealand. 61
33578727 2021
16
Modification of the Pulmonary MyD88 Inflammatory Response Underlies the Role of the Yersinia pestis Pigmentation Locus in Primary Pneumonic Plague. 61
33257532 2021
17
COVID-19, Contagion, and Vaccine Optimism. 61
33587203 2021
18
Protection against severe infectious disease in the past. 61
33573529 2021
19
Ensemble bootstrap methodology for forecasting dynamic growth processes using differential equations: application to epidemic outbreaks. 61
33583405 2021
20
A critical assessment of proposed outbreaks of plague and other epidemic diseases in Ancient Egypt. 61
33227516 2021
21
History of the Plague: An Ancient Pandemic for the Age of COVID-19. 61
32979306 2021
22
The role of louse-transmitted diseases in historical plague pandemics. 61
33035476 2021
23
Whole-Genome Assembly of Yersinia pestis 231, the Russian Reference Strain for Testing Plague Vaccine Protection. 61
33541878 2021
24
Biological characteristic and cytokines response of passages duck plague virus in ducks. 61
33549641 2021
25
A day in the life of a plague victim. 61
33608348 2021
26
In Vitro and In Vivo Characterization of Tebipenem (TBP), an Orally Active Carbapenem, against Biothreat Pathogens. 61
33593844 2021
27
Soil-Transmitted Helminths in the USA: a Review of Five Common Parasites and Future Directions for Avenues of Enhanced Epidemiologic Inquiry. 61
33552843 2021
28
Interplay between Yersinia pestis and its flea vector in lipoate metabolism. 61
33479491 2021
29
Local dynamics of a white syndrome outbreak and changes in the microbial community associated with colonies of the scleractinian brain coral Pseudodiploria strigosa. 61
33604172 2021
30
Endometrial preparation with etanercept increased embryo implantation and live birth rates in women suffering from recurrent implantation failure during IVF. 61
33476990 2021
31
Human population dynamics and Yersinia pestis in ancient northeast Asia. 61
33523963 2021
32
Ectoparasitic community of the Mahali mole-rat, Cryptomys hottentotus mahali: potential host for vectors of medical importance in South Africa. 61
33407807 2021
33
Modulation of Key Physio-Biochemical and Ultrastructural Attributes after Synergistic Application of Zinc and Silicon on Rice under Cadmium Stress. 61
33406626 2021
34
Neoliberal rationality and the age friendly cities and communities program: Reflections on the Toronto case. 61
33106719 2021
35
Genetic Diversity and Distribution of Virulence-Associated Genes in Y. enterocolitica and Y. enterocolitica-Like Isolates from Humans and Animals in Poland. 61
33450948 2021
36
Obesity and Endocrine Disrupting Chemicals. 61
33449914 2021
37
Excited-State Properties of Defected Halide Perovskite Quantum Dots: Insights from Computation. 61
33470811 2021
38
Human ABO Blood Groups and Their Associations with Different Diseases. 61
33564677 2021
39
Progress of public health policy regarding global infectious diseases over the past decade in Japan. 61
33472748 2021
40
Rodent Ectoparasites in the Middle East: A Systematic Review and Meta-Analysis. 61
33572506 2021
41
Vector-borne diseases in Iran: epidemiology and key challenges. 61
33438476 2021
42
Benefits of Sexual Activity on Psychological, Relational, and Sexual Health During the COVID-19 Breakout. 61
33234430 2021
43
Are we Athens or Florence? COVID-19 in historical context. 61
33526435 2021
44
The Yersinia pestis GTPase BipA Promotes Pathogenesis of Primary Pneumonic Plague. 61
33257531 2021
45
The influence of vector-borne disease on human history: socio-ecological mechanisms. 61
33501751 2021
46
Prevalence, Virulence and Antimicrobial Susceptibility of Salmonella spp., Yersinia enterocolitica and Listeria monocytogenes in European Wild Boar (Sus scrofa) Hunted in Tuscany (Central Italy). 61
33498307 2021
47
Evolution and circulation of Yersinia pestis in the Northern Caspian and Northern Aral Sea regions in the 20th-21st centuries. 61
33571993 2021
48
Screening of an FDA-Approved Library for Novel Drugs against Y. pestis. 61
33401634 2021
49
A Journal of the Plague Year. 61
33289934 2021
50
Plague Journal. 61
33371917 2021

Variations for Plague

Expression for Plague

Search GEO for disease gene expression data for Plague.

Pathways for Plague

GO Terms for Plague

Cellular components related to Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule membrane GO:0030667 8.8 RHOA PECAM1 FPR1

Biological processes related to Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.62 PECAM1 MYD88 CD86 CCR5
2 cytokine-mediated signaling pathway GO:0019221 9.56 MYD88 FPR1 CD86 CCR5
3 negative regulation of cell-substrate adhesion GO:0010812 9.37 RHOA PLG
4 viral process GO:0016032 9.35 RHOA DDX58 CDC25C CD86 CCR5
5 peptidyl-tyrosine dephosphorylation GO:0035335 9.33 PTPRU CDC25C ACP1
6 cellular response to lipopolysaccharide GO:0071222 8.92 RHOA MYD88 CD86 CCR5

Molecular functions related to Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.6 TYMP SULT1A2 SELE RHOA PTS PTPRU
2 protein tyrosine phosphatase activity GO:0004725 9.13 PTPRU CDC25C ACP1

Sources for Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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