MCID: PLG002
MIFTS: 54

Plague

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Plague

MalaCards integrated aliases for Plague:

Name: Plague 12 75 59 43 3 15 72 33
Yersiniosis 59 3
Yersinia Infections 72

Characteristics:

Orphanet epidemiological data:

59
plague
Prevalence: 1-9/100000 (Europe); Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:3482
ICD9CM 35 020 020.9
MeSH 44 D010930
NCIt 50 C85015
SNOMED-CT 68 58750007
ICD10 33 A20 A20.9
MESH via Orphanet 45 D010930 D015009
ICD10 via Orphanet 34 A20.0 A20.1 A20.2 more
UMLS via Orphanet 73 C0032064 C0043407
Orphanet 59 ORPHA707
UMLS 72 C0032064 C0043407

Summaries for Plague

MedlinePlus : 43 Plague is an infection caused by the bacterium Yersinia pestis. The bacteria are found mainly in rats and in the fleas that feed on them. People and other animals can get plague from rat or flea bites. In the past, plague destroyed entire civilizations. Today plague is uncommon, due to better living conditions and antibiotics. There are three forms of plague: Bubonic plague causes the tonsils, adenoids, spleen, and thymus to become inflamed. Symptoms include fever, aches, chills, and tender lymph glands. In septicemic plague, bacteria multiply in the blood. It causes fever, chills, shock, and bleeding under the skin or other organs. Pneumonic plague is the most serious form. Bacteria enter the lungs and cause pneumonia. People with the infection can spread this form to others. This type could be a bioterror agent. Lab tests can diagnose plague. Treatment is a strong antibiotic. There is no vaccine.

MalaCards based summary : Plague, also known as yersiniosis, is related to septicemic plague and pneumonic plague, and has symptoms including fever and pruritus. An important gene associated with Plague is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Human cytomegalovirus infection and NF-kappaB Signaling. The drugs Cycloserine and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and lymph node, and related phenotypes are Negative genetic interaction between KRASG13D/+ and KRAS+/- and cellular

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, located in lymph node, located in vasculature or located in lungs, has material basis in Yersinia pestis, which is transmitted by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted by air, transmitted by direct contact or transmitted by ingestion of contaminated undercooked food.

CDC : 3 Y. enterolitica are the most common species causing human enteric (intestinal) yersiniosis. Pigs are the major animal reservoir for the few strains of Y. enterocolitica that cause human illness, but rodents, rabbits, sheep, cattle, horses, dogs, and cats also can carry strains that cause human illness.

Wikipedia : 75 Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever,... more...

Related Diseases for Plague

Diseases related to Plague via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 septicemic plague 29.5 PLG MYD88
2 pneumonic plague 29.1 SULT1A2 PLG
3 diarrhea 10.5
4 reactive arthritis 10.4
5 lymphadenitis 10.4
6 mesenteric lymphadenitis 10.3
7 appendicitis 10.3
8 sulfamethoxazole allergy 10.3 CD86 CD83
9 ileitis 10.3
10 salmonellosis 10.3
11 enterocolitis 10.3
12 brucellosis 10.3
13 gastroenteritis 10.3
14 myositis fibrosa 10.2 MYD88 CD86
15 pulmonary vein stenosis 10.2 TYMP PECAM1
16 shigellosis 10.2
17 tularemia 10.2
18 crohn's disease 10.2
19 erythema multiforme 10.1
20 listeriosis 10.1
21 peritonitis 10.1
22 pfeiffer syndrome 10.0
23 thalassemia 10.0
24 bacterial infectious disease 10.0
25 hemosiderosis 10.0
26 dysentery 10.0
27 hepatitis a 10.0
28 uveitis 10.0
29 campylobacteriosis 10.0
30 panniculitis 10.0
31 hemoglobinopathy 10.0
32 acute pancreatitis 10.0
33 myocarditis 10.0
34 vasculitis 10.0
35 posttransplant acute limbic encephalitis 10.0
36 rare hereditary hemochromatosis 10.0
37 bubonic plague 9.9 PLG CCR5
38 myositis 9.9
39 triiodothyronine receptor auxiliary protein 9.9
40 sjogren syndrome 9.9
41 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
42 kawasaki disease 9.9
43 myd88 deficiency 9.9
44 hemoglobin h disease 9.9
45 beta-thalassemia 9.9
46 hemophagocytic lymphohistiocytosis 9.9
47 exanthem 9.9
48 colitis 9.9
49 crohn's colitis 9.9
50 sensorineural hearing loss 9.9

Graphical network of the top 20 diseases related to Plague:



Diseases related to Plague

Symptoms & Phenotypes for Plague

UMLS symptoms related to Plague:


fever, pruritus

GenomeRNAi Phenotypes related to Plague according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between KRASG13D/+ and KRAS+/- GR00255-A-5 9.1 CCR5 CD83 CDC25C MYD88 RHOA SULT1A2

MGI Mouse Phenotypes related to Plague:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 ACP1 CCR5 CD86 CDC25C DDX58 INVS
2 cardiovascular system MP:0005385 10.13 ACP1 CCR5 CD83 INVS MGAT1 MYD88
3 hematopoietic system MP:0005397 10 CCR5 CD83 CD86 DDX58 INVS MGAT1
4 digestive/alimentary MP:0005381 9.97 CCR5 CDC25C DDX58 INVS MYD88 PECAM1
5 homeostasis/metabolism MP:0005376 9.93 ACP1 CCR5 CD86 DDX58 INVS MGAT1
6 endocrine/exocrine gland MP:0005379 9.92 CD83 CD86 CDC25C INVS MGAT1 MYD88
7 immune system MP:0005387 9.7 ACP1 CCR5 CD83 CD86 DDX58 INVS
8 liver/biliary system MP:0005370 9.1 CCR5 DDX58 INVS PECAM1 PLG SELE

Drugs & Therapeutics for Plague

Drugs for Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 141)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cycloserine Approved Phase 4 68-41-7 6234 401
2
Nitric Oxide Approved Phase 4 10102-43-9 145068
3
Iloprost Approved, Investigational Phase 4 78919-13-8 6443959
4 Anti-Bacterial Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Antimetabolites Phase 4
7 Renal Agents Phase 4
8 Antibiotics, Antitubercular Phase 4
9 Antitubercular Agents Phase 4
10 Anti-Infective Agents, Urinary Phase 4
11 Soy Bean Phase 4
12 Neurotransmitter Agents Phase 4
13 Respiratory System Agents Phase 4
14 Free Radical Scavengers Phase 4
15 Antioxidants Phase 4
16 Protective Agents Phase 4
17 Anti-Asthmatic Agents Phase 4
18 Platelet Aggregation Inhibitors Phase 4
19 Vasodilator Agents Phase 4
20 Peripheral Nervous System Agents Phase 4
21 Autonomic Agents Phase 4
22 Bronchodilator Agents Phase 4
23 Endothelium-Dependent Relaxing Factors Phase 4
24
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
25 Gentamicins Phase 2, Phase 3
26 English Lavender Phase 3
27
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
28
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
29
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
30 Cytochrome P-450 Enzyme Inhibitors Phase 2
31 Antiparasitic Agents Phase 2
32 Cytochrome P-450 CYP1A2 Inhibitors Phase 2
33 Antiprotozoal Agents Phase 2
34 Antimalarials Phase 2
35 Vaccines Phase 2
36 Immunologic Factors Phase 2
37 Lipid Regulating Agents Phase 2
38 Rosuvastatin Calcium Phase 2 147098-20-2
39 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
40 Hypolipidemic Agents Phase 2
41 Anticholesteremic Agents Phase 2
42 Calcium, Dietary Phase 2
43
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
44 Gastrointestinal Agents Phase 1
45 Antacids Phase 1
46 Adjuvants, Immunologic Phase 1
47 Anti-Ulcer Agents Phase 1
48 Pharmaceutical Solutions Phase 1
49
Methotrexate Approved Early Phase 1 1959-05-2, 59-05-2 126941
50
leucovorin Approved Early Phase 1 58-05-9 143 6006

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Resuvastatin Treatment for Symptomatic Middle Cerebral Artery Stenosis Based on High-resolution Magnetic Resonance Imaging in Two Years Unknown status NCT02041117 Phase 4 Rosuvastatin
2 Pilot Study of Pretreatment D-cycloserine for CBT-assessment of Paranoid Delusions in Schizophrenia Completed NCT00742079 Phase 4 D-cycloserine
3 Multi-Center, Double-Blind, Placebo-Controlled, Monotherapy Study of Neptune Krill Oil (NKO™) in Early Stage Alzheimer's Disease Completed NCT00867828 Phase 4
4 OUTPATENT VASODILATOR ASSESSMENT USING ILOPROST IN PULMONARY HYPERTENSION (The OVATION Study) Recruiting NCT03044314 Phase 4 Illoprost and nitric oxide administration
5 Safety and Efficacy of Gentamicin Versus Streptomycin for the Treatment of Naturally Occurring Human Plague and Evaluation of Rapid Diagnostic Test Kits for Yersinia Pestis Completed NCT00128466 Phase 2, Phase 3 gentamicin;streptomycin
6 Effects of Lavender Oil on Postoperative Pain, Sleep Quality and Mood Recruiting NCT03093454 Phase 3 Lavender Essential Oil
7 A Randomized, Non-inferiority, Active Controlled Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin Versus Doxycycline in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline
8 Immunogenicity and Safety of Subunit Plague Vaccine Comprised by Fraction 1 Capsule (F1) and Virulence-Associated (V) Antigens: A Random Phase 2a Clinical Trial Completed NCT02596308 Phase 2
9 A Phase 2b Randomized, Single-Blinded Study to Evaluate the Safety and Immunogenicity of 80 µg Recombinant Plague Vaccine (rF1V) With and Without Adjuvant at Two Vaccination Schedules in Healthy Adult Volunteers Completed NCT01122784 Phase 2
10 A Phase 2 (a), Dose-Blinded, Block-Randomized, Dose and Schedule Selection Study to Evaluate the Immunogenicity and Safety of the Recombinant Plague Vaccine rF1V in Healthy Volunteers Completed NCT00332956 Phase 2
11 Effects of HMG-coA Reductase Inhibitor on Progression of Carotid Intima-Media Thickness and Arterial Stiffness in Rheumatoid Arthritis Completed NCT00555230 Phase 2 Rosuvastatin;Placebo
12 Exploring and Subtyping the Pathophysiology of Neurodegeneration in Late-life Depression: Implications for Treatment and Prognosis in the Future Active, not recruiting NCT03430869 Phase 2 F-18 AV-45;F-18-THK-5351
13 A Phase 1b, Multi-Centre, Parallel Group, Single Blind Study to Evaluate the Safety, Tolerability and Immunogenicity of a Recombinant Plague Vaccine (rF1 and rV Antigens) in Healthy Subjects Completed NCT00246467 Phase 1
14 A Phase 1, Open-Label, Dose-Escalating Study to Evaluate the Safety, Tolerability and Immunogenicity of the Recombinant Plague Vaccine rF1V in Healthy Volunteers Completed NCT00097396 Phase 1
15 A Phase I Safety and Immunogenicity Dose Escalation Trial of Plague Vaccine, Flagellin/F1/V, In Healthy Adult Volunteers Completed NCT01381744 Phase 1
16 A Pilot Study Examining for the Presence of Fecal Coliforms in Peruvian Water Sources and the Association of Tropical Diseases Within Peru Unknown status NCT03078894
17 The Effectiveness of an Oral Care Protocol in Preventing Ventilator- Associated Pneumonia for Intensive Care Unit Patient Completed NCT00604916 Early Phase 1
18 Health is Power: An Ecological Theory-based Health Intervention for Women of Color Completed NCT02394171
19 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies. What Does the Patient Suffer From When the Appendix Proves to be Healthy? Completed NCT03349814
20 Evaluation of Gingival Crevicular Fluid Levels of LL-37 and Serum Vitamin D3 Levels in Smoker and Non-Smoker Patients With Chronic Periodontitis Completed NCT03923218
21 Randomized Controlled Trial: Volar Plate vs. Conventus DRS Intramedullary Fixation for Distal Radius Fractures Completed NCT02390856
22 Activity & Cognition After Treatment (ACT) for Breast Cancer Completed NCT02592070
23 A Prospective Evaluation of an Anesthesia Protocol to Reduce Post-operative and Post-discharge Nausea and Vomiting in a High Risk Orthognathic Surgery Population Completed NCT01592708
24 Vascular Surgery Department of Beijing Tsinghua Chang Gung Hospital Recruiting NCT02820207
25 Augmentation of Screening Colonoscopy With Fecal Immunochemical Testing Recruiting NCT00892593
26 Blood And Clot Thrombectomy Registry And Collaboration (BACTRAC) Recruiting NCT03153683
27 InFACT Seed Proposal: Ohio State University Food Waste Collaborative Active, not recruiting NCT02790502
28 Parasitological Evaluation of Fascioliasis in Clinically Suspected Patients and the Effect of Some Plant Extract on The Adult Worm Not yet recruiting NCT03869788

Search NIH Clinical Center for Plague

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Ciprofloxacin
Demeclocycline
Doxycycline
Levofloxacin
Minocycline
Moxifloxacin
Streptomycin
Sulfadiazine
Tetracycline

Genetic Tests for Plague

Anatomical Context for Plague

MalaCards organs/tissues related to Plague:

41
Testes, Lung, Lymph Node, Skin, Spleen, T Cells, Tonsil

The Foundational Model of Anatomy Ontology organs/tissues related to Plague:

19
Lungs, Lymph Node, Vasculature

Publications for Plague

Articles related to Plague:

(show top 50) (show all 9438)
# Title Authors PMID Year
1
Quantification of low abundance Yersinia pestis markers in dried blood spots by immuno-capture and quantitative high-resolution targeted mass spectrometry. 38 17
31096787 2019
2
Phthalates and other endocrine-disrupting chemicals: the 21st century's plague for reproductive health. 38 17
30975386 2019
3
The Wakley-Wu Lien Teh Prize Essay 2019: telling the stories of Chinese doctors. 17
31282345 2019
4
Galectin-1 induces immune response and antiviral ability in Cherry Valley ducks after duck plague virus infection. 38
30986433 2019
5
Pyrimidine biosynthesis in pathogens - Structures and analysis of dihydroorotases from Yersinia pestis and Vibrio cholerae. 38
31207330 2019
6
Comment on the Editorial "The Plague of Plagiarism: Prevention and Cure!!!" 38
31391751 2019
7
Host biology and environmental variables differentially predict flea abundances for two rodent hosts in a plague-relevant system. 38
31193431 2019
8
Nutrient depletion may trigger the Yersinia pestis OmpR-EnvZ regulatory system to promote flea-borne plague transmission. 38
31424585 2019
9
Field assessment of insecticide dusting and bait station treatment impact against rodent flea and house flea species in the Madagascar plague context. 38
31386661 2019
10
Photochemically-Mediated, Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamate Esters. 38
31436104 2019
11
Comparative genomic characterization of the multimammate mouse Mastomys coucha. 38
31424545 2019
12
Twelve tips for clinicians dealing with uncertainty when assessing learners. 38
30299204 2019
13
>An exploration of undergraduate nursing assistant employment in aged care and its value to undergraduate nursing education. 38
31422175 2019
14
Fleas of the genus Tetrapsyllus (Siphonaptera:Rhopalopsyllidae) associated with rodents from Northwestern Argentina. 38
31011530 2019
15
Development of a multiple-antigen protein fusion vaccine candidate that confers protection against Bacillus anthracis and Yersinia pestis. 38
31430284 2019
16
Descriptive epidemiology of Yersinia enterocolitica infection in a high-incidence area over an 8-year period, 2006-2013. EDICS project. 38
30553619 2019
17
Comparative susceptibilities and immune-related gene expressions of brown trout strains and their hybrids infected with Lactococcus garvieae and Yersinia ruckeri. 38
31128294 2019
18
Heterogeneity of Highly Susceptible Yersinia enterocolitica Isolates of Clinical and Environmental Origin: A 5-Year Survey from Iran (2011-2016). 38
31414976 2019
19
T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly. 38
31427728 2019
20
Knowledge, attitudes, and practices relevant to zoonotic disease reporting and infection prevention practices among veterinarians - Arizona, 2015. 38
31311640 2019
21
Temperature Control of psaA Expression by PsaE and PsaF in Yersinia pestis. 38
31138630 2019
22
Investigation of a Yersinia enterocolitica outbreak in a commercial alpaca farm in Saskatchewan. 38
31391607 2019
23
Modeling Pneumonic Plague in Human Precision-Cut Lung Slices Highlights a Role for the Plasminogen Activator Protease in Facilitating Type 3 Secretion. 38
31085709 2019
24
Robust Th1 cellular and humoral responses generated by the Yersinia pestis rF1-V subunit vaccine formulated to contain an agonist of the CD137 pathway do not translate into increased protection against pneumonic plague. 38
31416643 2019
25
Identifying the spatiotemporal clusters of plague occurrences in China during the Third Pandemic. 38
31305020 2019
26
Improved method for genotyping the causative agent of crayfish plague (Aphanomyces astaci) based on mitochondrial DNA. 38
30975238 2019
27
Plague-Positive Mouse Fleas on Mice Before Plague Induced Die-Offs in Black-Tailed and White-Tailed Prairie Dogs. 38
30994405 2019
28
Pervasive Arctic lead pollution suggests substantial growth in medieval silver production modulated by plague, climate, and conflict. 38
31285330 2019
29
A new bunya-like virus associated with mass mortality of white-clawed crayfish in the wild. 38
31247401 2019
30
There and Back Again-The Journey of LiNiO2 as a Cathode Active Material. 38
30537189 2019
31
Development of a rapid viability polymerase chain reaction method for detection of Yersinia pestis. 38
31095987 2019
32
Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1α-RIG-I Antiviral Signaling. 38
31167774 2019
33
CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice. 38
31062296 2019
34
The signal crayfish (Pacifastacus leniusculus) in Lake Tahoe (USA) hosts multiple Aphanomyces species. 38
31330144 2019
35
Designing resilience research: Using multiple methods to investigate risk exposure, promotive and protective processes, and contextually relevant outcomes for children and youth. 38
31376582 2019
36
Solar-driven carbon dioxide fixation using photosynthetic semiconductor bio-hybrids. 38
30994635 2019
37
Genomic and molecular characterisation of Escherichia marmotae from wild rodents in Qinghai-Tibet plateau as a potential pathogen. 38
31337784 2019
38
Hyperspectral Images Denoising via Nonconvex Regularized Low-Rank and Sparse Matrix Decomposition. 38
31329555 2019
39
Graphene Quantum Dots as Nanozymes for Electrochemical Sensing of Yersinia enterocolitica in Milk and Human Serum. 38
31288382 2019
40
Hfq Globally Binds and Destabilizes sRNAs and mRNAs in Yersinia pestis. 38
31311844 2019
41
The next chapter of human-plague science. 38
31253701 2019
42
Patient Safety Issues Continue to Plague American Hospitals. 38
31359507 2019
43
A recombinant attenuated Yersinia pseudotuberculosis vaccine delivering a Y. pestis YopENt138-LcrV fusion elicits broad protection in mice against plague and yersiniosis. 38
31331960 2019
44
Drainage tube hole suture improvement: Removal-free stitches. 38
31368233 2019
45
Invasive Yersiniosis in a Pediatric Patient With β-Thalassemia Major: Acute Decompensation After Rapid Blood Transfusion. 38
31219970 2019
46
Upregulated LOX-1 Receptor: Key Player of the Pathogenesis of Atherosclerosis. 38
31350594 2019
47
Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy. 38
31268670 2019
48
Neuroterrorism Preparedness for the Neurohospitalist. 38
31244972 2019
49
Future climate change likely to reduce the Australian plague locust (Chortoicetes terminifera) seasonal outbreaks. 38
31018473 2019
50
Human plague system associated with rodent diversity and other environmental factors. 38
31312490 2019

Variations for Plague

Expression for Plague

Search GEO for disease gene expression data for Plague.

Pathways for Plague

GO Terms for Plague

Cellular components related to Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 PECAM1 CD86 CD83 CCR5

Biological processes related to Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-8 production GO:0032757 9.32 MYD88 DDX58
2 leukocyte cell-cell adhesion GO:0007159 9.26 SELE PECAM1
3 negative regulation of cell-substrate adhesion GO:0010812 9.16 RHOA PLG
4 regulation of cell migration GO:0030334 9.13 RHOA PECAM1 DDX58
5 viral process GO:0016032 9.02 RHOA DDX58 CDC25C CD86 CCR5

Sources for Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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