MCID: PLG002
MIFTS: 63

Plague

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Plague

MalaCards integrated aliases for Plague:

Name: Plague 12 74 58 42 3 15 71 32
Yersiniosis 58 3
Yersinia Infections 71

Characteristics:

Orphanet epidemiological data:

58
plague
Prevalence: 1-9/100000 (Europe); Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Plague

MedlinePlus : 42 Plague is an infection caused by the bacterium Yersinia pestis. The bacteria are found mainly in rats and in the fleas that feed on them. People and other animals can get plague from rat or flea bites. In the past, plague destroyed entire civilizations. Today plague is uncommon, due to better living conditions and antibiotics. There are three forms of plague: Bubonic plague causes the tonsils, adenoids, spleen, and thymus to become inflamed. Symptoms include fever, aches, chills, and tender lymph glands. In septicemic plague, bacteria multiply in the blood. It causes fever, chills, shock, and bleeding under the skin or other organs. Pneumonic plague is the most serious form. Bacteria enter the lungs and cause pneumonia. People with the infection can spread this form to others. This type could be a bioterror agent. Lab tests can diagnose plague. Treatment is a strong antibiotic. There is no vaccine.

MalaCards based summary : Plague, also known as yersiniosis, is related to reactive arthritis and ileitis, and has symptoms including fever and pruritus. An important gene associated with Plague is CCR5 (C-C Motif Chemokine Receptor 5), and among its related pathways/superpathways are Innate Immune System and Measles. The drugs Cycloserine and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, vasculature and lungs, and related phenotypes are fatigue and fever

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, located in lymph node, located in vasculature or located in lungs, has material basis in Yersinia pestis, which is transmitted by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted by air, transmitted by direct contact or transmitted by ingestion of contaminated undercooked food.

CDC : 3 Y. enterolitica are the most common species causing human enteric (intestinal) yersiniosis. Pigs are the major animal reservoir for the few strains of Y. enterocolitica that cause human illness, but rodents, rabbits, sheep, cattle, horses, dogs, and cats also can carry strains that cause human illness.

Wikipedia : 74 Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever,... more...

Related Diseases for Plague

Diseases related to Plague via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 reactive arthritis 31.3 TLR4 TLR2 CCR5
2 ileitis 31.1 TLR4 TLR2 CD4 CCR5
3 salmonellosis 31.1 TLR4 TLR2 MYD88 CD4
4 dysentery 30.9 TLR4 TLR2 CD4
5 tularemia 30.9 TLR4 TLR2 MYD88 CD4
6 listeriosis 30.8 TLR4 TLR2 MYD88 CD4
7 tick-borne encephalitis 30.7 TLR2 DDX58 CCR5
8 myd88 deficiency 30.6 TLR4 TLR2 MYD88
9 septicemic plague 30.6 SULT1A2 PLG CTSC
10 intestinal perforation 30.6 TLR4 PTS CD4
11 q fever 30.6 TLR4 TLR2 MYD88
12 toxoplasmosis 30.5 TLR4 TLR2 MYD88 CCR5
13 urethritis 30.5 TLR4 TLR2 CD4
14 amebiasis 30.5 TLR4 TLR2 CD4
15 kawasaki disease 30.5 SELE MYD88 CD4
16 bacterial infectious disease 30.4 TLR4 TLR2 MYD88 FPR1 CD86 CD4
17 vascular disease 30.2 TLR4 SELE PLG PECAM1 CD4
18 pneumonic plague 29.7 TLR4 TLR2 SULT1A2 SULT1A1 PLG HMSD
19 abacavir allergy 10.6 CD4 CCR5
20 gastrointestinal tularemia 10.5 TLR4 TLR2 MYD88
21 prosthetic joint infection 10.5 TLR4 TLR2
22 silo filler's disease 10.5 TLR4 TLR2 MYD88
23 lymphocytic choriomeningitis 10.5 TLR2 MYD88 DDX58 CD86
24 irak4 deficiency 10.5 TLR4 TLR2 MYD88
25 human monocytic ehrlichiosis 10.5 TLR2 MYD88 CD4
26 pulmonary artery leiomyosarcoma 10.5 PLG PECAM1
27 skin sarcoidosis 10.5 CD83 CD4
28 genital herpes 10.5 TLR2 CD4 CCR5
29 bacillary angiomatosis 10.5 PECAM1 CD4
30 fungal keratitis 10.5 TLR4 TLR2
31 endometritis 10.5 TLR4 TLR2 SELE
32 diarrhea 10.5
33 hereditary angioedema with normal c1inh 10.5 TLR4 TLR2 PLG
34 periodontitis, aggressive, 1 10.5 FPR1 CTSC
35 pleural empyema 10.5 PLG CTSC CD4
36 aphthous stomatitis 10.5 TLR4 TLR2 SELE
37 stomatitis 10.5 TLR4 DDX58 CD4
38 paracoccidioidomycosis 10.5 TLR4 TLR2 MYD88 CD86
39 acquired immunodeficiency syndrome 10.5 SELE PECAM1 CD4 CCR5
40 bacterial sepsis 10.5 TLR4 TLR2 SELE MYD88
41 herpes zoster 10.5 TLR2 CD4 CCR5
42 chlamydia pneumonia 10.5 TLR4 TLR2 CD4
43 combat disorder 10.5 TLR4 TLR2 CD4
44 autoimmune disease of cardiovascular system 10.5 TLR4 PLG CD4
45 legionellosis 10.5 TLR4 TLR2 MYD88
46 cervicitis 10.5 TLR4 TLR2 CD4
47 filarial elephantiasis 10.5 TLR4 TLR2 CD4
48 cutaneous leishmaniasis 10.5 TLR4 TLR2 CCR5
49 penile disease 10.4 TLR4 TLR2 CD4
50 gingival disease 10.4 TLR4 TLR2 CD4

Graphical network of the top 20 diseases related to Plague:



Diseases related to Plague

Symptoms & Phenotypes for Plague

Human phenotypes related to Plague:

58 31 (show top 50) (show all 53)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 lymphadenitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002840
4 splenomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0001744
5 hepatomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0002240
6 dry skin 58 31 frequent (33%) Frequent (79-30%) HP:0000958
7 abnormal blistering of the skin 58 31 frequent (33%) Frequent (79-30%) HP:0008066
8 skin ulcer 58 31 frequent (33%) Frequent (79-30%) HP:0200042
9 chest pain 58 31 frequent (33%) Frequent (79-30%) HP:0100749
10 anxiety 58 31 frequent (33%) Frequent (79-30%) HP:0000739
11 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
12 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
13 tachycardia 58 31 frequent (33%) Frequent (79-30%) HP:0001649
14 chills 58 31 frequent (33%) Frequent (79-30%) HP:0025143
15 conjunctival hyperemia 58 31 frequent (33%) Frequent (79-30%) HP:0030953
16 delirium 58 31 frequent (33%) Frequent (79-30%) HP:0031258
17 bacteremia 58 31 frequent (33%) Frequent (79-30%) HP:0031864
18 hearing impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000365
19 vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002013
20 edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0000969
21 skin rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0000988
22 arthralgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002829
23 slurred speech 58 31 occasional (7.5%) Occasional (29-5%) HP:0001350
24 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
25 depressivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0000716
26 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
27 sepsis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100806
28 hematemesis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002248
29 abnormality of the elbow 58 31 occasional (7.5%) Occasional (29-5%) HP:0009811
30 respiratory distress 58 31 occasional (7.5%) Occasional (29-5%) HP:0002098
31 hypotension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002615
32 glossitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000206
33 unsteady gait 58 31 occasional (7.5%) Occasional (29-5%) HP:0002317
34 mydriasis 58 31 occasional (7.5%) Occasional (29-5%) HP:0011499
35 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
36 erythema nodosum 58 31 occasional (7.5%) Occasional (29-5%) HP:0012219
37 enterocolitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004387
38 acute infectious pneumonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0011949
39 bloody diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0025085
40 enlarged mesenteric lymph node 58 31 occasional (7.5%) Occasional (29-5%) HP:0025043
41 chapped lip 58 31 occasional (7.5%) Occasional (29-5%) HP:0040181
42 arthritis 58 31 very rare (1%) Very rare (<4-1%) HP:0001369
43 muscle weakness 58 31 very rare (1%) Very rare (<4-1%) HP:0001324
44 endocarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0100584
45 meningitis 58 31 very rare (1%) Very rare (<4-1%) HP:0001287
46 inflammatory abnormality of the eye 58 31 very rare (1%) Very rare (<4-1%) HP:0100533
47 pharyngitis 58 31 very rare (1%) Very rare (<4-1%) HP:0025439
48 reduced consciousness/confusion 58 Frequent (79-30%)
49 arrhythmia 58 Occasional (29-5%)
50 inflammation of the large intestine 58 Occasional (29-5%)

UMLS symptoms related to Plague:


fever, pruritus

MGI Mouse Phenotypes related to Plague:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.33 ACP1 CCR5 CD4 CD86 CTSC DDX58
2 hematopoietic system MP:0005397 10.24 CCR5 CD4 CD83 CD86 CTSC DDX58
3 cardiovascular system MP:0005385 10.22 ACP1 CCR5 CD83 INVS MYD88 PECAM1
4 homeostasis/metabolism MP:0005376 10.22 ACP1 CCR5 CD4 CD86 CTSC DDX58
5 growth/size/body region MP:0005378 10.18 ACP1 CD4 CTSC DDX58 INVS MYD88
6 immune system MP:0005387 10.16 ACP1 CCR5 CD4 CD83 CD86 CTSC
7 digestive/alimentary MP:0005381 10.13 CCR5 CD4 DDX58 INVS MYD88 PECAM1
8 liver/biliary system MP:0005370 9.81 CCR5 DDX58 INVS MYD88 PECAM1 PLG
9 renal/urinary system MP:0005367 9.5 INVS MYD88 PECAM1 PLG RHOA TLR2
10 respiratory system MP:0005388 9.17 INVS MYD88 PECAM1 PLG SELE TLR2

Drugs & Therapeutics for Plague

Drugs for Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 126)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cycloserine Approved Phase 4 68-41-7 401 6234
2
Nitric Oxide Approved Phase 4 10102-43-9 145068
3
Iloprost Approved, Investigational Phase 4 78919-13-8 6443959
4
leucovorin Approved Phase 4 58-05-9 6006 143
5
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
6
Acitretin Approved Phase 4 55079-83-9, 69427-46-9 6437841
7
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
8
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
9
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
10 Anti-Bacterial Agents Phase 4
11 Antitubercular Agents Phase 4
12 Antibiotics, Antitubercular Phase 4
13 Soy Bean Phase 4
14 Respiratory System Agents Phase 4
15 Antioxidants Phase 4
16 Vasodilator Agents Phase 4
17 Protective Agents Phase 4
18 Endothelium-Dependent Relaxing Factors Phase 4
19 Bronchodilator Agents Phase 4
20 Anti-Asthmatic Agents Phase 4
21 Neurotransmitter Agents Phase 4
22 Immunologic Factors Phase 4
23 Anti-Infective Agents Phase 4
24 Antimetabolites Phase 4
25 Vitamin B Complex Phase 4
26 Folic Acid Antagonists Phase 4
27 Immunosuppressive Agents Phase 4
28 Dermatologic Agents Phase 4
29 Antifungal Agents Phase 4
30 Cyclosporins Phase 4
31 Folate Phase 4
32 Calcineurin Inhibitors Phase 4
33 Keratolytic Agents Phase 4
34 Antirheumatic Agents Phase 4
35 Vitamin B9 Phase 4
36
Streptomycin Approved, Vet_approved Phase 3 57-92-1 19649
37
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
38 Gentamicins Phase 2, Phase 3
39 English Lavender Phase 3
40 Cytochrome P-450 Enzyme Inhibitors Phase 3
41
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
42
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
43
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
44
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
45 Vaccines Phase 2
46 Rosuvastatin Calcium Phase 2 147098-20-2
47 Hypolipidemic Agents Phase 2
48 Anticholesteremic Agents Phase 2
49 Lipid Regulating Agents Phase 2
50 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Resuvastatin Treatment for Symptomatic Middle Cerebral Artery Stenosis Based on High-resolution Magnetic Resonance Imaging in Two Years Unknown status NCT02041117 Phase 4 Rosuvastatin
2 Pilot Study of Pretreatment D-cycloserine for CBT-assessment of Paranoid Delusions in Schizophrenia Completed NCT00742079 Phase 4 D-cycloserine
3 Multi-Center, Double-Blind, Placebo-Controlled, Monotherapy Study of Neptune Krill Oil (NKO™) in Early Stage Alzheimer's Disease Completed NCT00867828 Phase 4
4 OUTPATENT VASODILATOR ASSESSMENT USING ILOPROST IN PULMONARY HYPERTENSION (The OVATION Study) Recruiting NCT03044314 Phase 4 Illoprost and nitric oxide administration
5 Outcomes With Treatment and Withdraw of Secukinumab in Patients With Plaque Psoriasis Compared to Standard Care --- a Pragmatic Observational Study Not yet recruiting NCT04239859 Phase 4 Methotrexate;Cyclosporin A;Acitretin
6 Safety and Efficacy of Gentamicin Versus Streptomycin for the Treatment of Naturally Occurring Human Plague and Evaluation of Rapid Diagnostic Test Kits for Yersinia Pestis Completed NCT00128466 Phase 2, Phase 3 gentamicin;streptomycin
7 Effects of Lavender Oil on Postoperative Pain, Sleep Quality and Mood Completed NCT03093454 Phase 3 Lavender Essential Oil
8 An Open-label, Randomised, Non-inferiority Trial of the Efficacy and Safety of Ciprofloxacin Versus Streptomycin + Ciprofloxacin in the Treatment of Bubonic Plague Recruiting NCT04110340 Phase 3 Ciprofloxacin;Streptomycin
9 Effectiveness and Safety of Convalescent Plasma Therapy on COVID-19 Patients With Acute Respiratory Distress Syndrome in Referral Hospitals in Indonesia Not yet recruiting NCT04380935 Phase 2, Phase 3 Standard of care
10 A Randomized, Non-inferiority, Active Controlled Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin Versus Doxycycline in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline
11 Immunogenicity and Safety of Subunit Plague Vaccine Comprised by Fraction 1 Capsule (F1) and Virulence-Associated (V) Antigens: A Random Phase 2a Clinical Trial Completed NCT02596308 Phase 2
12 A Phase 2b Randomized, Single-Blinded Study to Evaluate the Safety and Immunogenicity of 80 µg Recombinant Plague Vaccine (rF1V) With and Without Adjuvant at Two Vaccination Schedules in Healthy Adult Volunteers Completed NCT01122784 Phase 2
13 A Phase 2 (a), Dose-Blinded, Block-Randomized, Dose and Schedule Selection Study to Evaluate the Immunogenicity and Safety of the Recombinant Plague Vaccine rF1V in Healthy Volunteers Completed NCT00332956 Phase 2
14 Effects of HMG-coA Reductase Inhibitor on Progression of Carotid Intima-Media Thickness and Arterial Stiffness in Rheumatoid Arthritis Completed NCT00555230 Phase 2 Rosuvastatin;Placebo
15 Pilot Study of Chinese Medicine Medicated Bath as Complementary Medicine for Mild to Moderate Plaque -Type Psoriasis Patient. Recruiting NCT04117919 Phase 2 paper mulberry leaf;Triamcinolone (Encort-A) 0.1%15g/Tube
16 Exploring and Subtyping the Pathophysiology of Neurodegeneration in Late-life Depression: Implications for Treatment and Prognosis in the Future Active, not recruiting NCT03430869 Phase 2 F-18 AV-45;F-18-THK-5351
17 A Phase 1b, Multi-Centre, Parallel Group, Single Blind Study to Evaluate the Safety, Tolerability and Immunogenicity of a Recombinant Plague Vaccine (rF1 and rV Antigens) in Healthy Subjects Completed NCT00246467 Phase 1
18 A Phase 1, Open-Label, Dose-Escalating Study to Evaluate the Safety, Tolerability and Immunogenicity of the Recombinant Plague Vaccine rF1V in Healthy Volunteers Completed NCT00097396 Phase 1
19 A Phase I Safety and Immunogenicity Dose Escalation Trial of Plague Vaccine, Flagellin/F1/V, In Healthy Adult Volunteers Completed NCT01381744 Phase 1
20 Augmentation of Screening Colonoscopy With Fecal Immunochemical Testing Unknown status NCT00892593
21 A Pilot Study Examining for the Presence of Fecal Coliforms in Peruvian Water Sources and the Association of Tropical Diseases Within Peru Unknown status NCT03078894
22 InFACT Seed Proposal: Ohio State University Food Waste Collaborative Unknown status NCT02790502
23 The Effectiveness of an Oral Care Protocol in Preventing Ventilator- Associated Pneumonia for Intensive Care Unit Patient Completed NCT00604916 Early Phase 1
24 Health is Power: An Ecological Theory-based Health Intervention for Women of Color Completed NCT02394171
25 An Observational Cross-sectional Study to Compare Carbamylated High-density Lipoprotein Levels Among Normal Subjects, Type 2 Diabetes Mellitus Patients With and Without Coronary Heart Disease. Completed NCT04390711
26 Explanations for Negative Laparoscopic Appendectomies and Normal Laparoscopies. What Does the Patient Suffer From When the Appendix Proves to be Healthy? Completed NCT03349814
27 Evaluation of Gingival Crevicular Fluid Levels of LL-37 and Serum Vitamin D3 Levels in Smoker and Non-Smoker Patients With Chronic Periodontitis Completed NCT03923218
28 Activity & Cognition After Treatment (ACT) for Breast Cancer Completed NCT02592070
29 Randomized Controlled Trial: Volar Plate vs. Conventus DRS Intramedullary Fixation for Distal Radius Fractures Completed NCT02390856
30 A Prospective Evaluation of an Anesthesia Protocol to Reduce Post-operative and Post-discharge Nausea and Vomiting in a High Risk Orthognathic Surgery Population Completed NCT01592708
31 Vascular Surgery Department of Beijing Tsinghua Chang Gung Hospital Recruiting NCT02820207
32 PERIPHERAL NERVE BLOCKS WITH LOW DOSE LIGNOCAINE FOR THE TREATMENT OF ACUTE LUMBOSACRAL RADICULOPATHY Recruiting NCT04215757
33 Blood And Clot Thrombectomy Registry And Collaboration (BACTRAC) Recruiting NCT03153683
34 Field Evaluation of a Point-of-care Triage Test for Active Tuberculosis Not yet recruiting NCT04232618
35 Parasitological Evaluation of Fascioliasis in Clinically Suspected Patients and the Effect of Some Plant Extract on The Adult Worm Not yet recruiting NCT03869788
36 SNAP HOME: Smart No-show Analytics Paired With Home-based Outpatient Medical Engagement Suspended NCT04376736

Search NIH Clinical Center for Plague

Genetic Tests for Plague

Anatomical Context for Plague

The Foundational Model of Anatomy Ontology organs/tissues related to Plague:

19
Lymph Node, Vasculature, Lungs

MalaCards organs/tissues related to Plague:

40
Testes, Lung, Skin, Lymph Node, Spleen, T Cells, Tonsil

Publications for Plague

Articles related to Plague:

(show top 50) (show all 9694)
# Title Authors PMID Year
1
Psychosocial Reactions to Plagues in the Cultural History of Medicine: A Medical Humanities Approach. 61 42
32472811 2020
2
Salvation in a Time of Plague. 42 61
32449663 2020
3
The Bubonic Plague in San Francisco. 42 61
32427296 2020
4
Antibacterial and antibiofilm activities of diphyllin against fish pathogens. 61
32353578 2020
5
Surgeons, plague, and leadership: A historical mantle to carry forward. 61
32386712 2020
6
Access to Lung Transplantation in the United States: The Potential Impact of Access to a High-volume Center. 61
32569004 2020
7
The characteristics and genome analysis of the novel Y. pestis phage JC221. 61
32315702 2020
8
Threats from the coronavirus, lessons from the plague. 61
32434670 2020
9
Art in Science: Pieter Bruegel the Elder and the Plague. 61
32574469 2020
10
Pandemics, regional outbreaks, and sudden-onset disasters. 61
32022584 2020
11
The modern plague of antivaccine extremists. 61
32007566 2020
12
miR-135b levels in the peripheral blood serve as a marker associated with acute ischemic stroke. 61
32346417 2020
13
A temperature-dependent translation defect caused by IRES mutation attenuates foot-and-mouth disease virus: Implications for rational vaccine design. 61
32493820 2020
14
Emerging Spine Care Trends and Innovations. 61
32389252 2020
15
The Opioid-Tolerant Patient: Opioid Optimization. 61
32014381 2020
16
Delivery of RNAi-Based Therapeutics for Bone Regeneration. 61
32394316 2020
17
Renewable energy, urbanization, and ecological footprint linkage in CIVETS. 61
32219652 2020
18
What have we learned from animal models of idiosyncratic, drug-induced liver injury? 61
32324077 2020
19
Medieval menarche: Changes in pubertal timing before and after the Black Death. 61
32567154 2020
20
Bakkenolides and Caffeoylquinic Acids from the Aerial Portion of Petasites japonicus and Their Bacterial Neuraminidase Inhibition Ability. 61
32532086 2020
21
Conditions Influencing Collaboration Among the Primary Care Disciplines as They Prepare the Future Primary Care Physician Workforce. 61
32196119 2020
22
A Prospective Examination of Racial Microaggressions in the Medical Encounter. 61
31845288 2020
23
Covariance pattern mixture models: Eliminating random effects to improve convergence and performance. 61
31512175 2020
24
Journal of a plague year. 61
32505247 2020
25
Writing about the plague. 61
32521199 2020
26
Immunization Against Plague: An Argument for Controlled Experiment. 61
32515807 2020
27
Life Imitates Art: The Physician in a Time of Plague. 61
32289308 2020
28
Managing plague on prairie dog colonies: insecticides as ectoparasiticides. 61
32492281 2020
29
Medical Valor in Plague Time: Dr. Benjamin Rush. 61
32312653 2020
30
Climate drivers of plague epidemiology in British India, 1898-1949. 61
32517609 2020
31
'A plague o' both your houses': Selected Quotations for Our Times. 61
32234497 2020
32
Crayfish plague in Czechia: Outbreaks from novel sources and testing for chronic infections. 61
32353366 2020
33
Genetic and molecular features for hepadnavirus and plague infections in the Himalayan marmot. 61
32308030 2020
34
Correction for Namouchi et al., Integrative approach using Yersinia pestis genomes to revisit the historical landscape of plague during the Medieval Period. 61
32457145 2020
35
Influence of Temperature on Development of Yersinia pestis Foregut Blockage in Xenopsylla cheopis (Siphonaptera: Pulicidae) and Oropsylla montana (Siphonaptera: Ceratophyllidae). 61
32533162 2020
36
Contagious Diseases and its Consequences in the Late Qajar Period Mashhad (1892-1921). 61
32536181 2020
37
A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity. 61
32560686 2020
38
COVID-19 and Other Pandemics: How Might They Be Prevented? 61
32478500 2020
39
Spring in London with Covid-19: a personal view. 61
32515258 2020
40
SARS-CoV-2: A comprehensive review from pathogenicity of the virus to clinical consequences. 61
32492197 2020
41
[The "Plague Doctor's Mask" in the German Museum for the History of Medicine, Ingolstadt]. 61
32451562 2020
42
A treponemal genome from an historic plague victim supports a recent emergence of yaws and its presence in 15th century Europe. 61
32528126 2020
43
Factors Influencing Atypical Clinical Presentations during the 2017 Madagascar Pneumonic Plague Outbreak: A Prospective Cohort Study. 61
32274983 2020
44
The plague in Bologna in the year 1527. 61
32487796 2020
45
Detection of Rickettsia felis in ectoparasites collected from domestic animals. 61
32472468 2020
46
Host range of Triatoma virus does not extend to Aedes aegypti and Apis mellifera. 61
32298695 2020
47
Protection against fowl cholera in ducks immunized with a combination vaccine containing live attenuated duck enteritis virus and recombinant outer membrane protein H of Pasteurella multocida. 61
31899951 2020
48
Putative Horizontally Acquired Genes, Highly Transcribed during Yersinia pestis Flea Infection, Are Induced by Hyperosmotic Stress and Function in Aromatic Amino Acid Metabolism. 61
32205462 2020
49
Study of the effect of cypermethrin on the spider Polybetes phytagoricus in different energy states. 61
32359558 2020
50
Implementing Artificial Intelligence and Digital Health in Resource-Limited Settings? Top 10 Lessons We Learned in Congenital Heart Defects and Cardiology. 61
31592719 2020

Variations for Plague

Expression for Plague

Search GEO for disease gene expression data for Plague.

Pathways for Plague

Pathways related to Plague according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 TLR4 TLR2 RHOA PECAM1 MYD88 FPR1
2
Show member pathways
12.66 TLR4 TLR2 PLG MYD88 DDX58
3
Show member pathways
12.5 TLR4 TLR2 RHOA MYD88 CD86 CD4
4 12.28 TLR2 PECAM1 MYD88 DDX58 CD83
5 12.14 TLR4 TLR2 RHOA MYD88
6
Show member pathways
12.09 TLR4 TLR2 MYD88 CCR5
7
Show member pathways
12.04 TLR4 TLR2 RHOA MYD88 CD83 CD4
8 12.03 TLR4 TLR2 RHOA MYD88
9 11.9 SELE PECAM1 CD86 CD4
10 11.79 TLR4 MYD88 DDX58
11 11.77 TLR4 MYD88 CD4
12 11.73 TLR4 TLR2 CD86
13 11.68 TLR4 TLR2 RHOA
14
Show member pathways
11.65 TLR4 TLR2 CD86 CD4
15 11.6 TLR4 RHOA MYD88
16
Show member pathways
11.53 RHOA PLG MYD88
17
Show member pathways
11.52 TLR4 TLR2 CD86 CD4
18 11.43 TLR4 TLR2 MYD88
19 11.32 FPR1 CD86 CCR5
20 10.72 TLR4 TLR2 SELE PECAM1 MYD88
21 10.01 SULT1A2 SULT1A1

GO Terms for Plague

Cellular components related to Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.13 TLR4 TLR2 SELE RHOA PLG PECAM1
2 cytoplasm GO:0005737 10.13 TLR4 TLR2 SULT1A2 SULT1A1 RHOA PTS
3 integral component of plasma membrane GO:0005887 9.95 TLR4 TLR2 SELE PECAM1 CD83 CD4
4 membrane raft GO:0045121 9.67 TLR2 SELE PECAM1 CD4
5 cell surface GO:0009986 9.63 TLR4 TLR2 PLG CD86 CD4 CCR5
6 secretory granule membrane GO:0030667 9.26 TLR2 RHOA PECAM1 FPR1
7 external side of plasma membrane GO:0009897 9.1 TLR4 PECAM1 CD86 CD83 CD4 CCR5

Biological processes related to Plague according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.22 TLR4 TLR2 PECAM1 MYD88 FPR1 CD86
2 immune system process GO:0002376 10.09 TLR4 TLR2 MYD88 DDX58 CD86 CD4
3 viral process GO:0016032 10.06 RHOA DDX58 CD86 CD4 CCR5
4 neutrophil degranulation GO:0043312 10.02 TLR2 RHOA PECAM1 FPR1 CTSC
5 immune response GO:0006955 9.93 TLR4 TLR2 CTSC CD86 CD4 CCR5
6 cell surface receptor signaling pathway GO:0007166 9.92 PECAM1 MYD88 CD86 CD4 CCR5
7 cytokine-mediated signaling pathway GO:0019221 9.89 MYD88 FPR1 CD86 CD4 CCR5
8 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.88 TLR4 RHOA MYD88 CD4
9 response to lipopolysaccharide GO:0032496 9.86 TLR4 TLR2 SELE MYD88
10 regulation of cell migration GO:0030334 9.85 RHOA PECAM1 DDX58
11 regulation of inflammatory response GO:0050727 9.83 TLR4 SELE MYD88
12 phagocytosis GO:0006909 9.79 TLR4 PECAM1 MYD88
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.77 TLR4 TLR2 RHOA
14 positive regulation of tumor necrosis factor production GO:0032760 9.75 TLR4 TLR2 MYD88
15 inflammatory response GO:0006954 9.73 TLR4 TLR2 SELE MYD88 FPR1 CCR5
16 toll-like receptor signaling pathway GO:0002224 9.72 TLR4 TLR2 MYD88
17 positive regulation of interleukin-6 secretion GO:2000778 9.71 TLR4 TLR2 DDX58
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 TLR4 TLR2 MYD88
19 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 TLR4 TLR2
20 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.66 CD86 CD4
21 positive regulation of interferon-alpha production GO:0032727 9.65 TLR4 DDX58
22 ethanol catabolic process GO:0006068 9.65 SULT1A2 SULT1A1
23 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.65 TLR4 MYD88
24 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.65 TLR4 TLR2 MYD88
25 I-kappaB phosphorylation GO:0007252 9.64 TLR4 TLR2
26 catecholamine metabolic process GO:0006584 9.64 SULT1A2 SULT1A1
27 cellular response to lipoteichoic acid GO:0071223 9.63 TLR4 TLR2
28 sulfation GO:0051923 9.63 SULT1A2 SULT1A1
29 positive regulation of lymphocyte proliferation GO:0050671 9.61 TLR4 MYD88
30 positive regulation of interferon-beta production GO:0032728 9.61 TLR4 TLR2 DDX58
31 fusion of virus membrane with host plasma membrane GO:0019064 9.59 CD4 CCR5
32 cellular response to lipopolysaccharide GO:0071222 9.55 TLR4 RHOA MYD88 CD86 CCR5
33 positive regulation of interleukin-10 production GO:0032733 9.5 TLR4 TLR2 CD83
34 positive regulation of matrix metallopeptidase secretion GO:1904466 9.4 TLR4 TLR2
35 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.37 TLR4 TLR2
36 positive regulation of interleukin-6 production GO:0032755 9.26 TLR4 TLR2 MYD88 DDX58
37 positive regulation of interleukin-8 production GO:0032757 8.92 TLR4 TLR2 MYD88 DDX58

Molecular functions related to Plague according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.76 TLR4 TLR2 CD86 CD4
2 identical protein binding GO:0042802 9.76 TLR4 TLR2 PTS MYD88 DDX58 CTSC
3 virus receptor activity GO:0001618 9.61 CD86 CD4 CCR5
4 protein binding GO:0005515 9.6 TLR4 TLR2 SULT1A2 SULT1A1 SELE RHOA
5 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.49 TLR4 TLR2
6 NAD(P)+ nucleosidase activity GO:0050135 9.48 TLR4 TLR2
7 coreceptor activity GO:0015026 9.43 CD86 CD4 CCR5
8 aryl sulfotransferase activity GO:0004062 9.4 SULT1A2 SULT1A1
9 Toll-like receptor binding GO:0035325 9.37 TLR2 MYD88
10 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 TLR2
11 flavonol 3-sulfotransferase activity GO:0047894 8.96 SULT1A2 SULT1A1

Sources for Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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