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MCID: PLN003
MIFTS: 33

Plantar Fascial Fibromatosis

Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Plantar Fascial Fibromatosis

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MalaCards integrated aliases for Plantar Fascial Fibromatosis:

Name: Plantar Fascial Fibromatosis 12 15 32
Dupuytren's Contracture of Foot 12
Fibromatosis, Plantar 43
Ledderhose's Disease 12
Ledderhose Disease 71

Classifications:

ICD10: 32


External Ids:

Disease Ontology 12 DOID:8936
ICD9CM 34 728.71
MeSH 43 D000071380
NCIt 49 C4680
SNOMED-CT 67 13370002
ICD10 32 M72.2
UMLS 71 C0158360
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Summaries for Plantar Fascial Fibromatosis

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Disease Ontology : 12 A connective tissue disease characterized by progressive fibrosis and thickening located in the palmar fascia and has symptom early painless nodules, has symptom decreased range of motion, has symptom weakened grip, and has symptom eventual contracture.

MalaCards based summary : Plantar Fascial Fibromatosis, also known as dupuytren's contracture of foot, is related to ledderhose disease and plantar fasciitis, and has symptoms including early painless nodules, decreased range of motion and weakened grip. An important gene associated with Plantar Fascial Fibromatosis is AKTIP (AKT Interacting Protein), and among its related pathways/superpathways are p70S6K Signaling and AGE-RAGE signaling pathway in diabetic complications. Affiliated tissues include palmar fascia, and related phenotypes are adipose tissue and cardiovascular system

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Related Diseases for Plantar Fascial Fibromatosis

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Diseases related to Plantar Fascial Fibromatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 ledderhose disease 12.0
2 plantar fasciitis 10.7
3 fibromatosis 10.2
4 leprosy 3 10.1
5 plantar wart 10.1
6 47,xyy 10.1
7 hansen's disease 10.1
8 malt worker's lung 10.1 SETD2 SETD1A
9 larsen-like syndrome 10.1 COL3A1 COL1A1
10 pseudosarcomatous fibromatosis 10.0 COL1A1 CDH11 AKTIP
11 ehlers-danlos syndrome, classic type, 1 9.9 COL3A1 COL1A1
12 meningococcal infection 9.7 AGTR1 AGT
13 fibromuscular dysplasia 9.6 AGTR1 AGT
14 renal artery disease 9.5 AGTR1 AGT
15 posterior urethral valves 9.5 AGTR2 AGTR1 AGT
16 renal hypertension 9.5 AGTR2 AGTR1 AGT
17 familial hypertension 9.4 AGTR1 AGT
18 orthostatic intolerance 9.4 COL3A1 COL1A1 AGTR1
19 odontochondrodysplasia 9.3 GUSB GAPDH COL3A1 COL1A1
20 vesicoureteral reflux 1 9.3 RUSF1 AGTR2 AGTR1 AGT
21 marfan syndrome 9.3 COL3A1 COL1A1 AGTR1
22 otosclerosis 9.3 COL1A1 AGTR1 AGT
23 anuria 9.3 AGTR1 AGT
24 pulmonary fibrosis, idiopathic 9.1 GAPDH COL3A1 COL1A1 AGTR2 AGT

Comorbidity relations with Plantar Fascial Fibromatosis via Phenotypic Disease Network (PDN):


Heel Spur

Graphical network of the top 20 diseases related to Plantar Fascial Fibromatosis:



Diseases related to Plantar Fascial Fibromatosis
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Symptoms & Phenotypes for Plantar Fascial Fibromatosis

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Symptoms:

12
  • • early painless nodules
  • • decreased range of motion
  • • weakened grip
  • • eventual contracture

UMLS symptoms related to Plantar Fascial Fibromatosis:


metatarsalgia

MGI Mouse Phenotypes related to Plantar Fascial Fibromatosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 10.02 AGT AGTR1 AGTR2 AKTIP COL1A1 COL3A1
2 cardiovascular system MP:0005385 10.02 AGT AGTR1 AGTR2 AKTIP ATP6AP2 COL1A1
3 homeostasis/metabolism MP:0005376 9.97 AGT AGTR1 AGTR2 AKTIP ATP6AP2 COL1A1
4 hematopoietic system MP:0005397 9.96 AGTR1 AGTR2 COL1A1 COL3A1 GAPDH GUSB
5 immune system MP:0005387 9.65 AGT AGTR1 AGTR2 AKTIP COL1A1 COL3A1
6 renal/urinary system MP:0005367 9.23 AGT AGTR1 AGTR2 AKTIP ATP6AP2 COL1A1
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Drugs & Therapeutics for Plantar Fascial Fibromatosis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ledderhose Disease: Radiotherapy or Not? A Randomised, Multicentre, Prospective, Double Blind Phase III Trial Investigating the Effect of Radiotherapy on Patients With Ledderhose Disease Recruiting NCT03507010 Phase 3
2 Does Fibrosis Diathesis Influence the Recovery of Knee Mobility After Total Knee Replacement? Unknown status NCT02294890
3 Ledderhose Disease - Long Term Effects of Radiotherapy Treatment. LedRad LTE - Study Active, not recruiting NCT04229147
4 Phase IIa Trial of Low Dose Radiation THerapy to Reduce Cerebral Amyloidosis in Early Alzheimer's Dementia Active, not recruiting NCT02769000

Search NIH Clinical Center for Plantar Fascial Fibromatosis

Cochrane evidence based reviews: fibromatosis, plantar

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Genetic Tests for Plantar Fascial Fibromatosis

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Anatomical Context for Plantar Fascial Fibromatosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Plantar Fascial Fibromatosis:

19
Palmar Fascia
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Publications for Plantar Fascial Fibromatosis

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Articles related to Plantar Fascial Fibromatosis:

(show all 37)
# Title Authors PMID Year
1
The Effects of Collagenase Clostridium histolyticum on Plantar Fibromatosis: A Case Study. 61
31679681 2019
2
Ledderhose Disease: Pathophysiology Diagnosis and Management. 61
31534943 2019
3
Erosive Arthritis, Fibromatosis, and Keloids: A Rare Dermatoarthropathy. 61
29850357 2018
4
Plantar Fascial Fibromatosis: Two Cases Treated With Low-Energy Focused Shock Waves. 61
28002162 2017
5
Plantar Fibromatosis and Other Fibroblastic and Fibrohistiocytic Soft Tissue Tumors of the Foot. 61
29461202 2017
6
Surgical Treatment of a Case of Ledderhose's Disease: A Safe Plantar Approach to Subtotal Fasciectomy. 61
26783478 2015
7
Ledderhose's disease: radiologic/pathologic correlation of superficial plantar fibromatosis. 61
24630152 2014
8
[Dupuytren's disease]. 61
24422298 2013
9
[Ledderhose's disease--an update on therapeutic options]. 61
23173284 2012
10
High-energy focussed extracorporeal shockwave therapy reduces pain in plantar fibromatosis (Ledderhose's disease). 61
23031080 2012
11
[Concomitance of Ledderhose's disease with Dupuytren's contracture. Own experience]. 61
23401985 2012
12
[Plantar fibromatosis and Dupuytren's contracture in an adolescent]. 61
22165757 2011
13
[Plantar fibromatosis (Ledderhose's disease)]. 61
21059334 2010
14
The treatment of severe flexion contracture of the great toe in a patient with Ledderhose's disease. 61
17901009 2009
15
[Plantar fibromatosis: ultrasonography results]. 61
10432963 1999
16
Fine needle aspiration biopsy of fibromatoses. 61
8498134 1993
17
Ledderhose's disease: case study with histologic and ultrastructural analysis. 61
1399528 1992
18
[Ledderhose's disease]. 61
1843082 1991
19
[Ledderhose's disease. Report of 7 cases]. 61
2269689 1990
20
[Ledderhose's disease in children]. 61
6234524 1984
21
Multiple recurring plantar fibromatosis and its surgical excision. 61
6863833 1983
22
[Ledderhose disease (case considerations)]. 61
6927030 1982
23
[Ledderhose's disease]. 61
546523 1979
24
Pathology of "knuckle pads". Study of four cases. 61
804749 1975
25
Dupuytren's contracture: fibroblast contraction? An ultrastructural study. 61
5009249 1972
26
[Medicolegal approach to Ledderhose's disease. 2 cases]. 61
4401750 1971
27
[Ledderhose's disease]. 61
5690306 1968
28
[Ledderhose's disease. (Presentation of 3 cases)]. 61
5944458 1966
29
[Plantar fibromatosis. Ledderhose's disease]. 61
13866473 1962
30
[What is Ledderhose's disease? The fibrous thickening of the plantar aponeurosis]. 61
13824471 1959
31
[New data on Ledderhose's disease: fibrous thickening of the plantar aponeurosis]. 61
13824470 1959
32
Ledderhose's disease. 61
13494646 1957
33
[Differential diagnosis of Ledderhose's disease, fibrolipoma of the two foot soles]. 61
13432447 1956
34
[Ledderhose's disease indicating a diagnosis of leprosy]. 61
13396477 1956
35
[Diagnosis of Ledderhose's disease: fibrolipoma of the two soles of the feet]. 61
13311235 1955
36
[A new case of Ledderhose's disease]. 61
14386611 1955
37
[Plastic surgery of the foot; verruca plantaris and Ledderhose's disease]. 61
12982024 1952
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Variations for Plantar Fascial Fibromatosis

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Expression for Plantar Fascial Fibromatosis

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Search GEO for disease gene expression data for Plantar Fascial Fibromatosis.
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Pathways for Plantar Fascial Fibromatosis

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Pathways related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
p70S6K Signaling 63
Show member pathways
 12.54 RRAS OGN AGTR2 AGTR1 AGT
2
AGE-RAGE signaling pathway in diabetic complications 36
11.26 COL3A1 COL1A1 AGTR1 AGT
3
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 60
Show member pathways
 10.83 ATP6AP2 AGTR2 AGTR1 AGT
4
Cori Cycle 1
10.36 PGK1 GAPDH
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GO Terms for Plantar Fascial Fibromatosis

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Cellular components related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 PGK1 OGN GUSB COL3A1 COL1A1 ATP6AP2
2 collagen-containing extracellular matrix GO:0062023 9.26 OGN COL3A1 COL1A1 AGT
3 extracellular exosome GO:0070062 9.23 RRAS PGK1 OGN GUSB GAPDH CDH11

Biological processes related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.79 COL3A1 COL1A1 CDH11
2 kidney development GO:0001822 9.73 AGTR2 AGTR1 AGT
3 positive regulation of extrinsic apoptotic signaling pathway GO:2001238 9.62 AGTR2 AGT
4 canonical glycolysis GO:0061621 9.62 PGK1 GAPDH
5 positive regulation of blood vessel diameter GO:0097755 9.61 AGTR2 AGT
6 regulation of vasoconstriction GO:0019229 9.6 AGTR1 AGT
7 regulation of blood vessel diameter GO:0097746 9.59 AGTR2 AGTR1
8 vasodilation GO:0042311 9.58 AGTR2 AGT
9 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.58 AGTR2 AGT
10 nitric oxide mediated signal transduction GO:0007263 9.57 AGTR2 AGT
11 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.55 AGTR1 AGT
12 cellular sodium ion homeostasis GO:0006883 9.54 AGTR2 AGT
13 positive regulation of cellular protein metabolic process GO:0032270 9.52 AGTR1 AGT
14 cell growth involved in cardiac muscle cell development GO:0061049 9.51 AGTR2 AGT
15 positive regulation of renal sodium excretion GO:0035815 9.49 AGTR2 AGT
16 low-density lipoprotein particle remodeling GO:0034374 9.48 AGTR1 AGT
17 angiotensin-activated signaling pathway GO:0038166 9.46 AGTR2 AGTR1
18 positive regulation of cholesterol esterification GO:0010873 9.43 AGTR1 AGT
19 positive regulation of NAD(P)H oxidase activity GO:0033864 9.4 AGTR1 AGT
20 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.37 AGTR1 AGT
21 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.32 AGTR2 AGT
22 regulation of renal sodium excretion GO:0035813 9.26 AGTR1 AGT
23 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.16 AGTR1 AGT
24 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199 8.96 AGTR2 AGT
25 renin-angiotensin regulation of aldosterone production GO:0002018 8.8 AGTR2 AGTR1 AGT

Molecular functions related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone-lysine N-methyltransferase activity GO:0018024 9.16 SETD2 SETD1A
2 platelet-derived growth factor binding GO:0048407 8.96 COL3A1 COL1A1
3 angiotensin type II receptor activity GO:0004945 8.62 AGTR2 AGTR1
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Sources for Plantar Fascial Fibromatosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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