Plantar Fascial Fibromatosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PLN003 MIFTS: 35	Plantar Fascial Fibromatosis
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Plantar Fascial Fibromatosis

MalaCards integrated aliases for Plantar Fascial Fibromatosis:

Name: Plantar Fascial Fibromatosis ¹² ¹⁵ ³²

Dupuytren's Contracture of Foot ¹²

Fibromatosis, Plantar ⁴³

Ledderhose's Disease ¹²

Ledderhose Disease ⁷¹

Classifications:

ICD10: ³²

Diseases of the musculoskeletal system and connective tissue

Other soft tissue disorders

Fibroblastic disorders

Plantar fascial fibromatosis

External Ids:

Disease Ontology ¹² DOID:8936

ICD9CM ³⁴ 728.71

MeSH ⁴³ D000071380

NCIt ⁴⁹ C4680

SNOMED-CT ⁶⁷ 13370002

ICD10 ³² M72.2

UMLS ⁷¹ C0158360

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Summaries for Plantar Fascial Fibromatosis

Disease Ontology : ¹² A connective tissue disease characterized by progressive fibrosis and thickening located in the palmar fascia and has symptom early painless nodules, has symptom decreased range of motion, has symptom weakened grip, and has symptom eventual contracture.

MalaCards based summary : Plantar Fascial Fibromatosis, also known as dupuytren's contracture of foot, is related to ledderhose disease and plantar fasciitis, and has symptoms including early painless nodules, decreased range of motion and weakened grip. An important gene associated with Plantar Fascial Fibromatosis is AKTIP (AKT Interacting Protein), and among its related pathways/superpathways are p70S6K Signaling and cGMP-PKG signaling pathway. Affiliated tissues include palmar fascia, and related phenotypes are Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers and Decreased influenza A H1N1 (A/WSN/33) virus numbers

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Related Diseases for Plantar Fascial Fibromatosis

Diseases related to Plantar Fascial Fibromatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)

#	Related Disease	Score	Top Affiliating Genes
1	ledderhose disease	12.0
2	plantar fasciitis	10.7
3	fibromatosis	10.2
4	larsen-like syndrome	10.1	COL3A1 COL1A1
5	leprosy 3	10.1
6	plantar wart	10.1
7	47,xyy	10.1
8	hansen's disease	10.1
9	tenosynovitis	10.1	MRAP AKTIP
10	ehlers-danlos syndrome, classic type, 1	10.1	COL3A1 COL1A1
11	pseudosarcomatous fibromatosis	10.0	COL1A1 CDH11 AKTIP
12	inhibited male orgasm	10.0	OGN MAPK14
13	meningococcal infection	10.0	AGTR1 AGT
14	fibromuscular dysplasia	10.0	AGTR1 AGT
15	hypermobility syndrome	10.0	COL3A1 COL1A1
16	renal artery disease	9.9	AGTR1 AGT
17	familial hypertension	9.9	AGTR1 AGT
18	tendinitis	9.9	MRAP AKTIP
19	posterior urethral valves	9.8	AGTR2 AGTR1 AGT
20	renal hypertension	9.8	AGTR2 AGTR1 AGT
21	frozen shoulder	9.7	MRAP COL1A1
22	marfan syndrome	9.7	COL3A1 COL1A1 AGTR1
23	otosclerosis	9.7	COL1A1 AGTR1 AGT
24	ureteral obstruction	9.6	MAPK14 AGTR2 AGTR1
25	anuria	9.6	AGTR1 AGT
26	end stage renal failure	9.5	AGTR2 AGTR1 AGT
27	pulmonary fibrosis, idiopathic	9.5	COL3A1 COL1A1 AGTR2 AGT
28	interstitial nephritis	9.4	B2M AGTR1 AGT
29	vesicoureteral reflux 1	9.0	C16orf58 B2M AGTR2 AGTR1 AGT
30	diabetes mellitus, insulin-dependent	8.8	MAPK14 B2M AGTR1 AGT
31	dilated cardiomyopathy	8.3	MAPK14 COL3A1 COL1A1 B2M AGTR1 AGT

Comorbidity relations with Plantar Fascial Fibromatosis via Phenotypic Disease Network (PDN):

Heel Spur

Graphical network of the top 20 diseases related to Plantar Fascial Fibromatosis:

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Symptoms & Phenotypes for Plantar Fascial Fibromatosis

Symptoms:

¹²

• early painless nodules
• decreased range of motion

• weakened grip
• eventual contracture

UMLS symptoms related to Plantar Fascial Fibromatosis:

metatarsalgia

GenomeRNAi Phenotypes related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers	GR00195-A-3	9.13	AKTIP ATP6AP2 B2M
2	Decreased influenza A H1N1 (A/WSN/33) virus numbers	GR00195-A-2	8.8	AKTIP ATP6AP2 B2M

MGI Mouse Phenotypes related to Plantar Fascial Fibromatosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.18	AGT AGTR1 AGTR2 ATP6AP2 B2M COL1A1
2	cardiovascular system	MP:0005385	10.16	AGT AGTR1 AGTR2 AKTIP ATP6AP2 B2M
3	hematopoietic system	MP:0005397	10.09	AGTR1 AGTR2 B2M COL1A1 COL3A1 GUSB
4	immune system	MP:0005387	10.07	AGT AGTR1 AGTR2 AKTIP B2M COL1A1
5	adipose tissue	MP:0005375	10.02	AGT AGTR1 AGTR2 AKTIP COL1A1 COL3A1
6	integument	MP:0010771	9.97	AGTR2 AKTIP B2M CDH11 COL1A1 COL3A1
7	mortality/aging	MP:0010768	9.9	AGT AGTR1 AGTR2 AKTIP ATP6AP2 B2M
8	liver/biliary system	MP:0005370	9.86	AGT AKTIP ATP6AP2 B2M COL1A1 COL3A1
9	neoplasm	MP:0002006	9.43	AGTR2 AKTIP B2M COL1A1 MAPK14 RRAS
10	renal/urinary system	MP:0005367	9.17	AGT AGTR1 AGTR2 AKTIP ATP6AP2 COL1A1

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Drugs & Therapeutics for Plantar Fascial Fibromatosis

Interventional clinical trials:

#	Name	Status	NCT ID	Phase
1	Ledderhose Disease: Radiotherapy or Not? A Randomised, Multicentre, Prospective, Double Blind Phase III Trial Investigating the Effect of Radiotherapy on Patients With Ledderhose Disease	Recruiting	NCT03507010	Phase 3
2	Does Fibrosis Diathesis Influence the Recovery of Knee Mobility After Total Knee Replacement?	Unknown status	NCT02294890
3	Phase IIa Trial of Low Dose Radiation THerapy to Reduce Cerebral Amyloidosis in Early Alzheimer's Dementia	Recruiting	NCT02769000

Search NIH Clinical Center for Plantar Fascial Fibromatosis

Cochrane evidence based reviews: fibromatosis, plantar

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Genetic Tests for Plantar Fascial Fibromatosis

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Anatomical Context for Plantar Fascial Fibromatosis

The Foundational Model of Anatomy Ontology organs/tissues related to Plantar Fascial Fibromatosis:

¹⁹

Palmar Fascia

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Publications for Plantar Fascial Fibromatosis

Articles related to Plantar Fascial Fibromatosis:

(show all 37)

#	Title	Authors	PMID	Year
1	The Effects of Collagenase Clostridium histolyticum on Plantar Fibromatosis: A Case Study. ⁶¹	Lehrman JD...Kaplan MA	31679681	2019
2	Ledderhose Disease: Pathophysiology Diagnosis and Management. ⁶¹	S SS...Susruthan M	31534943	2019
3	Erosive Arthritis, Fibromatosis, and Keloids: A Rare Dermatoarthropathy. ⁶¹	Aslam F...Noland SS	29850357	2018
4	Plantar Fascial Fibromatosis: Two Cases Treated With Low-Energy Focused Shock Waves. ⁶¹	Frizziero A...Meneghini A	28002162	2017
5	Plantar Fibromatosis and Other Fibroblastic and Fibrohistiocytic Soft Tissue Tumors of the Foot. ⁶¹	Ersoy H...Pomeranz SJ	29461202	2017
6	Surgical Treatment of a Case of Ledderhose's Disease: A Safe Plantar Approach to Subtotal Fasciectomy. ⁶¹	Souza BG...de Oliveira VM	26783478	2015
7	Ledderhose's disease: radiologic/pathologic correlation of superficial plantar fibromatosis. ⁶¹	Adib O...Aube C	24630152	2014
8	[Dupuytren's disease]. ⁶¹	Masmejean E...Tordjman D	24422298	2013
9	[Ledderhose's disease--an update on therapeutic options]. ⁶¹	Knobloch K	23173284	2012
10	High-energy focussed extracorporeal shockwave therapy reduces pain in plantar fibromatosis (Ledderhose's disease). ⁶¹	Knobloch K...Vogt PM	23031080	2012
11	[Concomitance of Ledderhose's disease with Dupuytren's contracture. Own experience]. ⁶¹	Trybus M...Lorkowski J	23401985	2012
12	[Plantar fibromatosis and Dupuytren's contracture in an adolescent]. ⁶¹	Nikolic J...Harhai V	22165757	2011
13	[Plantar fibromatosis (Ledderhose's disease)]. ⁶¹	Koudela K...Koudelova J	21059334	2010
14	The treatment of severe flexion contracture of the great toe in a patient with Ledderhose's disease. ⁶¹	Barnes DE...Allison K	17901009	2009
15	[Plantar fibromatosis: ultrasonography results]. ⁶¹	Solivetti FM...Muscardin L	10432963	1999
16	Fine needle aspiration biopsy of fibromatoses. ⁶¹	Raab SS...Geisinger KR	8498134	1993
17	Ledderhose's disease: case study with histologic and ultrastructural analysis. ⁶¹	Farsetti P...Bellocci M	1399528	1992
18	[Ledderhose's disease]. ⁶¹	Bardelli M...Veneziani C	1843082	1991
19	[Ledderhose's disease. Report of 7 cases]. ⁶¹	Dartoy C...Courtois B	2269689	1990
20	[Ledderhose's disease in children]. ⁶¹	Verge J...Bouygues D	6234524	1984
21	Multiple recurring plantar fibromatosis and its surgical excision. ⁶¹	Wiseman GG	6863833	1983
22	[Ledderhose disease (case considerations)]. ⁶¹	Bottinelli NF	6927030	1982
23	[Ledderhose's disease]. ⁶¹	Dell'Orto R...Percudani W	546523	1979
24	Pathology of "knuckle pads". Study of four cases. ⁶¹	Lagier R...Meinecke R	804749	1975
25	Dupuytren's contracture: fibroblast contraction? An ultrastructural study. ⁶¹	Gabbiani G...Majno G	5009249	1972
26	[Medicolegal approach to Ledderhose's disease. 2 cases]. ⁶¹	Lazarini HJ...Benezech M	4401750	1971
27	[Ledderhose's disease]. ⁶¹	Horvath G	5690306	1968
28	[Ledderhose's disease. (Presentation of 3 cases)]. ⁶¹	Federzoni F	5944458	1966
29	[Plantar fibromatosis. Ledderhose's disease]. ⁶¹	BEDOGNI C...DAL MONTE A	13866473	1962
30	[What is Ledderhose's disease? The fibrous thickening of the plantar aponeurosis]. ⁶¹	FRANCON F...EXERTIER J	13824471	1959
31	[New data on Ledderhose's disease: fibrous thickening of the plantar aponeurosis]. ⁶¹	FRANCON F...EXERTIER J	13824470	1959
32	Ledderhose's disease. ⁶¹	DEMETRAKOPOULOS NJ...MASON ML	13494646	1957
33	[Differential diagnosis of Ledderhose's disease, fibrolipoma of the two foot soles]. ⁶¹	FRANCON F	13432447	1956
34	[Ledderhose's disease indicating a diagnosis of leprosy]. ⁶¹	BLUM P...WELTI H	13396477	1956
35	[Diagnosis of Ledderhose's disease: fibrolipoma of the two soles of the feet]. ⁶¹	FRANCON F	13311235	1955
36	[A new case of Ledderhose's disease]. ⁶¹	FRANCON F...MASSOT H	14386611	1955
37	[Plastic surgery of the foot; verruca plantaris and Ledderhose's disease]. ⁶¹	JOLICOEUR A	12982024	1952

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Genes for Plantar Fascial Fibromatosis

Genes related to Plantar Fascial Fibromatosis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AKTIP	AKT Interacting Protein	Protein Coding	6.03	DISEASES inferred ¹⁵
2	C16orf58	Chromosome 16 Open Reading Frame 58	Protein Coding	5.38	DISEASES inferred ¹⁵
3	ATP6AP2	ATPase H+ Transporting Accessory Protein 2	Protein Coding	4.74	DISEASES inferred ¹⁵
4	OGN	Osteoglycin	Protein Coding	4.72	DISEASES inferred ¹⁵
5	CDH11	Cadherin 11	Protein Coding	4.59	DISEASES inferred ¹⁵
6	RRAS	RAS Related	Protein Coding	4.37	DISEASES inferred ¹⁵
7	GUSB	Glucuronidase Beta	Protein Coding	4.31	DISEASES inferred ¹⁵
8	PGK1	Phosphoglycerate Kinase 1	Protein Coding	4.3	DISEASES inferred ¹⁵
9	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	4.3	DISEASES inferred ¹⁵
10	AGTR2	Angiotensin II Receptor Type 2	Protein Coding	4.23	DISEASES inferred ¹⁵
11	AGT	Angiotensinogen	Protein Coding	4.01	DISEASES inferred ¹⁵
12	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	3.85	DISEASES inferred ¹⁵
13	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	3.74	DISEASES inferred ¹⁵
14	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	3.6	DISEASES inferred ¹⁵
15	B2M	Beta-2-Microglobulin	Protein Coding	3.38	DISEASES inferred ¹⁵
16	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	3.36	DISEASES inferred ¹⁵

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Variations for Plantar Fascial Fibromatosis

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Expression for Plantar Fascial Fibromatosis

Search GEO for disease gene expression data for Plantar Fascial Fibromatosis.

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Pathways for Plantar Fascial Fibromatosis

Pathways related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	p70S6K Signaling ⁶³ Show member pathways mTOR Pathway ⁶³ Renin-Angiotensin Pathway ⁶³	12.52	RRAS OGN MAPK14 AGTR2 AGTR1 AGT
2	cGMP-PKG signaling pathway ³⁶ Show member pathways Adrenergic signaling in cardiomyocytes ³⁶	12.06	MAPK14 AGTR2 AGTR1 AGT
3	ADP signalling through P2Y purinoceptor 1 ⁶⁵ Show member pathways Development Angiotensin signaling via beta-Arrestin ²² Signal amplification ⁶⁵ Thrombin signalling through proteinase activated receptors (PARs) ⁶⁵ Thromboxane signalling through TP receptor ⁶⁵	11.86	MAPK14 AGTR1 AGT
4	Platelet activation ³⁶	11.64	MAPK14 COL3A1 COL1A1
5	Senescence and Autophagy in Cancer ¹	11.52	MAPK14 COL3A1 COL1A1
6	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics ⁶⁰ Show member pathways ACE Inhibitor Pathway ¹ ACE Inhibitor Pathway, Pharmacodynamics ⁶⁰ Renin-angiotensin system ³⁶	11.16	ATP6AP2 AGTR2 AGTR1 AGT
7	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.02	MAPK14 COL3A1 COL1A1 AGTR1 AGT
8	Physiological and Pathological Hypertrophy of the Heart ¹	10.85	MAPK14 AGT
9	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease ¹	10.83	MAPK14 AGTR1
10	VEGFR3 signaling in lymphatic endothelium ¹	10.77	MAPK14 COL1A1

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GO Terms for Plantar Fascial Fibromatosis

Cellular components related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.56	RRAS PGK1 OGN GUSB CDH11 B2M
2	collagen-containing extracellular matrix	GO:0062023	9.46	OGN COL3A1 COL1A1 AGT
3	extracellular space	GO:0005615	9.23	PGK1 OGN GUSB COL3A1 COL1A1 B2M

Biological processes related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	skeletal system development	GO:0001501	9.79	COL3A1 COL1A1 CDH11
2	positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	9.62	AGTR2 AGT
3	positive regulation of blood vessel diameter	GO:0097755	9.61	AGTR2 AGT
4	regulation of vasoconstriction	GO:0019229	9.6	AGTR1 AGT
5	regulation of blood vessel diameter	GO:0097746	9.59	AGTR2 AGTR1
6	nitric oxide mediated signal transduction	GO:0007263	9.58	AGTR2 AGT
7	positive regulation of branching involved in ureteric bud morphogenesis	GO:0090190	9.58	AGTR2 AGT
8	vasodilation	GO:0042311	9.57	AGTR2 AGT
9	positive regulation of cellular protein metabolic process	GO:0032270	9.56	AGTR1 AGT
10	positive regulation of macrophage derived foam cell differentiation	GO:0010744	9.55	AGTR1 AGT
11	cellular sodium ion homeostasis	GO:0006883	9.54	AGTR2 AGT
12	cell growth involved in cardiac muscle cell development	GO:0061049	9.52	AGTR2 AGT
13	positive regulation of renal sodium excretion	GO:0035815	9.51	AGTR2 AGT
14	low-density lipoprotein particle remodeling	GO:0034374	9.49	AGTR1 AGT
15	angiotensin-activated signaling pathway	GO:0038166	9.48	AGTR2 AGTR1
16	positive regulation of cholesterol esterification	GO:0010873	9.46	AGTR1 AGT
17	positive regulation of NAD(P)H oxidase activity	GO:0033864	9.43	AGTR1 AGT
18	regulation of systemic arterial blood pressure by renin-angiotensin	GO:0003081	9.4	AGTR1 AGT
19	negative regulation of neurotrophin TRK receptor signaling pathway	GO:0051387	9.37	AGTR2 AGT
20	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.33	MAPK14 AGTR1 AGT
21	regulation of renal sodium excretion	GO:0035813	9.32	AGTR1 AGT
22	regulation of blood vessel diameter by renin-angiotensin	GO:0002034	9.26	AGTR1 AGT
23	G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	GO:0007199	8.96	AGTR2 AGT
24	renin-angiotensin regulation of aldosterone production	GO:0002018	8.8	AGTR2 AGTR1 AGT

Molecular functions related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	platelet-derived growth factor binding	GO:0048407	8.96	COL3A1 COL1A1
2	angiotensin type II receptor activity	GO:0004945	8.62	AGTR2 AGTR1

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Sources for Plantar Fascial Fibromatosis

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²⁵ Genetics Home Reference

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⁵⁶ OMIM

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⁶¹ PubMed

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⁷⁴ Wikipedia