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MCID: PLN003
MIFTS: 33

Plantar Fascial Fibromatosis

Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Plantar Fascial Fibromatosis

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MalaCards integrated aliases for Plantar Fascial Fibromatosis:

Name: Plantar Fascial Fibromatosis 12 15 32
Dupuytren's Contracture of Foot 12
Fibromatosis, Plantar 44
Ledderhose's Disease 12
Ledderhose Disease 71

Classifications:

ICD10: 32


External Ids:

Disease Ontology 12 DOID:8936
ICD9CM 34 728.71
MeSH 44 D000071380
NCIt 50 C4680
SNOMED-CT 67 240032001
ICD10 32 M72.2
UMLS 71 C0158360
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Summaries for Plantar Fascial Fibromatosis

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Disease Ontology : 12 A connective tissue disease characterized by progressive fibrosis and thickening located in the palmar fascia and has symptom early painless nodules, has symptom decreased range of motion, has symptom weakened grip, and has symptom eventual contracture.

MalaCards based summary : Plantar Fascial Fibromatosis, also known as dupuytren's contracture of foot, is related to ledderhose disease and plantar fasciitis, and has symptoms including early painless nodules, decreased range of motion and weakened grip. An important gene associated with Plantar Fascial Fibromatosis is ATP6AP2 (ATPase H+ Transporting Accessory Protein 2), and among its related pathways/superpathways are Glycosaminoglycan metabolism and AGE-RAGE signaling pathway in diabetic complications. Affiliated tissues include palmar fascia, and related phenotypes are cardiovascular system and growth/size/body region

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Related Diseases for Plantar Fascial Fibromatosis

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Diseases related to Plantar Fascial Fibromatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 ledderhose disease 11.4
2 plantar fasciitis 10.4
3 fibromatosis 10.1
4 larsen-like syndrome 10.1 COL3A1 COL1A1
5 aldosterone-producing adenoma 10.1 AGTR2 AGTR1
6 haverhill fever 10.0 GUSB B2M
7 pseudosarcomatous fibromatosis 10.0 COL1A1 CDH11
8 hypermobility syndrome 10.0 COL3A1 COL1A1
9 leprosy 3 10.0
10 plantar wart 10.0
11 hansen's disease 10.0
12 meningococcal infection 10.0 AGTR1 AGT
13 myocardial stunning 10.0 AGTR2 AGTR1
14 fibromuscular dysplasia 10.0 AGTR1 AGT
15 renal artery disease 9.9 AGTR1 AGT
16 malignant secondary hypertension 9.9 AGTR1 AGT
17 ehlers-danlos syndrome, classic type, 1 9.9 COL3A1 COL1A1
18 familial hypertension 9.9 AGTR1 AGT
19 anuria 9.9 AGTR1 AGT
20 renal tubular dysgenesis 9.9 AGTR1 AGT
21 proteinuria, chronic benign 9.8 B2M AGTR1
22 posterior urethral valves 9.8 AGTR2 AGTR1 AGT
23 malignant hypertension 9.8 AGTR1 AGT
24 renal hypodysplasia/aplasia 1 9.8 AGTR2 AGTR1 AGT
25 diastolic heart failure 9.8 AGTR1 AGT
26 interstitial nephritis 9.7 B2M AGTR1 AGT
27 marfan syndrome 9.7 COL3A1 COL1A1 AGTR1
28 otosclerosis 9.7 COL1A1 AGTR1 AGT
29 end stage renal disease 9.6 B2M AGTR1 AGT
30 renal hypertension 9.6 AGTR1 AGT
31 loeys-dietz syndrome 9.6 GAPDH COL3A1 AGTR1
32 vesicoureteral reflux 1 9.5 B2M AGTR2 AGTR1 AGT
33 kidney disease 9.5 B2M AGTR2 AGTR1 AGT
34 odontochondrodysplasia 9.4 GUSB GAPDH COL3A1 COL1A1
35 hypertrophic cardiomyopathy 9.2 COL3A1 COL1A1 AGTR1 AGT
36 polycystic kidney disease 9.2 GAPDH B2M AGTR1 AGT
37 pulmonary fibrosis, idiopathic 9.2 GAPDH COL3A1 COL1A1 AGTR2 AGT
38 myocardial infarction 9.1 GAPDH COL3A1 AGTR2 AGTR1 AGT
39 hypertension, essential 8.9 GAPDH B2M ATP6AP2 AGTR2 AGTR1 AGT
40 dilated cardiomyopathy 8.8 GAPDH COL3A1 COL1A1 B2M AGTR1 AGT

Comorbidity relations with Plantar Fascial Fibromatosis via Phenotypic Disease Network (PDN):


Heel Spur

Graphical network of the top 20 diseases related to Plantar Fascial Fibromatosis:



Diseases related to Plantar Fascial Fibromatosis
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Symptoms & Phenotypes for Plantar Fascial Fibromatosis

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Symptoms:

12
  • • early painless nodules
  • • decreased range of motion
  • • weakened grip
  • • eventual contracture

UMLS symptoms related to Plantar Fascial Fibromatosis:


metatarsalgia

MGI Mouse Phenotypes related to Plantar Fascial Fibromatosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 AGT AGTR1 AGTR2 ATP6AP2 B2M CDH11
2 growth/size/body region MP:0005378 10.02 AGT AGTR1 AGTR2 B2M COL1A1 COL3A1
3 homeostasis/metabolism MP:0005376 9.96 AGT AGTR1 AGTR2 ATP6AP2 B2M COL1A1
4 hematopoietic system MP:0005397 9.92 AGTR1 AGTR2 B2M COL1A1 COL3A1 GAPDH
5 adipose tissue MP:0005375 9.91 AGT AGTR1 AGTR2 COL1A1 COL3A1 GUSB
6 integument MP:0010771 9.7 AGTR2 B2M CDH11 COL1A1 COL3A1 GUSB
7 liver/biliary system MP:0005370 9.43 AGT ATP6AP2 B2M COL1A1 COL3A1 GAPDH
8 renal/urinary system MP:0005367 9.17 AGT AGTR1 AGTR2 ATP6AP2 COL1A1 GAPDH
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Drugs & Therapeutics for Plantar Fascial Fibromatosis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ledderhose Disease: Radiotherapy or Not? A Randomised, Multicentre, Prospective, Double Blind Phase III Trial Investigating the Effect of Radiotherapy on Patients With Ledderhose Disease Active, not recruiting NCT03507010 Phase 3
2 Ledderhose Disease - Long Term Effects of Radiotherapy Treatment. LedRad LTE - Study Completed NCT04229147

Search NIH Clinical Center for Plantar Fascial Fibromatosis

Cochrane evidence based reviews: fibromatosis, plantar

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Genetic Tests for Plantar Fascial Fibromatosis

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Anatomical Context for Plantar Fascial Fibromatosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Plantar Fascial Fibromatosis:

19
Palmar Fascia
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Publications for Plantar Fascial Fibromatosis

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Articles related to Plantar Fascial Fibromatosis:

(show all 37)
# Title Authors PMID Year
1
The Effects of Collagenase Clostridium histolyticum on Plantar Fibromatosis: A Case Study. 61
31679681 2019
2
Ledderhose Disease: Pathophysiology Diagnosis and Management. 61
31534943 2019
3
Erosive Arthritis, Fibromatosis, and Keloids: A Rare Dermatoarthropathy. 61
29850357 2018
4
Plantar Fibromatosis and Other Fibroblastic and Fibrohistiocytic Soft Tissue Tumors of the Foot. 61
29461202 2017
5
Plantar Fascial Fibromatosis: Two Cases Treated With Low-Energy Focused Shock Waves. 61
28002162 2017
6
Surgical Treatment of a Case of Ledderhose's Disease: A Safe Plantar Approach to Subtotal Fasciectomy. 61
26783478 2015
7
Ledderhose's disease: radiologic/pathologic correlation of superficial plantar fibromatosis. 61
24630152 2014
8
[Dupuytren's disease]. 61
24422298 2013
9
[Ledderhose's disease--an update on therapeutic options]. 61
23173284 2012
10
High-energy focussed extracorporeal shockwave therapy reduces pain in plantar fibromatosis (Ledderhose's disease). 61
23031080 2012
11
[Concomitance of Ledderhose's disease with Dupuytren's contracture. Own experience]. 61
23401985 2012
12
[Plantar fibromatosis and Dupuytren's contracture in an adolescent]. 61
22165757 2011
13
[Plantar fibromatosis (Ledderhose's disease)]. 61
21059334 2010
14
The treatment of severe flexion contracture of the great toe in a patient with Ledderhose's disease. 61
17901009 2009
15
[Plantar fibromatosis: ultrasonography results]. 61
10432963 1999
16
Fine needle aspiration biopsy of fibromatoses. 61
8498134 1993
17
Ledderhose's disease: case study with histologic and ultrastructural analysis. 61
1399528 1992
18
[Ledderhose's disease]. 61
1843082 1991
19
[Ledderhose's disease. Report of 7 cases]. 61
2269689 1990
20
[Ledderhose's disease in children]. 61
6234524 1984
21
Multiple recurring plantar fibromatosis and its surgical excision. 61
6863833 1983
22
[Ledderhose disease (case considerations)]. 61
6927030 1982
23
[Ledderhose's disease]. 61
546523 1979
24
Pathology of "knuckle pads". Study of four cases. 61
804749 1975
25
Dupuytren's contracture: fibroblast contraction? An ultrastructural study. 61
5009249 1972
26
[Medicolegal approach to Ledderhose's disease. 2 cases]. 61
4401750 1971
27
[Ledderhose's disease]. 61
5690306 1968
28
[Ledderhose's disease. (Presentation of 3 cases)]. 61
5944458 1966
29
[Plantar fibromatosis. Ledderhose's disease]. 61
13866473 1962
30
[What is Ledderhose's disease? The fibrous thickening of the plantar aponeurosis]. 61
13824471 1959
31
[New data on Ledderhose's disease: fibrous thickening of the plantar aponeurosis]. 61
13824470 1959
32
Ledderhose's disease. 61
13494646 1957
33
[Differential diagnosis of Ledderhose's disease, fibrolipoma of the two foot soles]. 61
13432447 1956
34
[Ledderhose's disease indicating a diagnosis of leprosy]. 61
13396477 1956
35
[Diagnosis of Ledderhose's disease: fibrolipoma of the two soles of the feet]. 61
13311235 1955
36
[A new case of Ledderhose's disease]. 61
14386611 1955
37
[Plastic surgery of the foot; verruca plantaris and Ledderhose's disease]. 61
12982024 1952
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Variations for Plantar Fascial Fibromatosis

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Expression for Plantar Fascial Fibromatosis

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Search GEO for disease gene expression data for Plantar Fascial Fibromatosis.
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Pathways for Plantar Fascial Fibromatosis

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Pathways related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Glycosaminoglycan metabolism 65
Show member pathways
 12.37 PGK1 OGN GUSB GAPDH
2
AGE-RAGE signaling pathway in diabetic complications 36
11.26 COL3A1 COL1A1 AGTR1 AGT
3
Inflammatory Response Pathway 1
10.89 COL3A1 COL1A1
4
ACE Inhibitor Pathway, Pharmacodynamics 60
Show member pathways
 10.83 ATP6AP2 AGTR2 AGTR1 AGT
5
G-protein signaling_Rap2B regulation pathway 23
10.46 OGN COL3A1 COL1A1 CDH11
6
Cori Cycle 1
10.36 PGK1 GAPDH
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GO Terms for Plantar Fascial Fibromatosis

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Cellular components related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 PGK1 OGN GUSB GAPDH CDH11 B2M
2 collagen-containing extracellular matrix GO:0062023 9.46 OGN COL3A1 COL1A1 AGT
3 extracellular space GO:0005615 9.23 PGK1 OGN GUSB COL3A1 COL1A1 B2M

Biological processes related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.81 COL3A1 COL1A1 B2M
2 skeletal system development GO:0001501 9.76 COL3A1 COL1A1 CDH11
3 kidney development GO:0001822 9.71 AGTR2 AGTR1 AGT
4 glycolytic process GO:0006096 9.64 PGK1 GAPDH
5 blood vessel remodeling GO:0001974 9.63 AGTR2 AGT
6 positive regulation of reactive oxygen species metabolic process GO:2000379 9.63 AGTR1 AGT
7 positive regulation of extrinsic apoptotic signaling pathway GO:2001238 9.62 AGTR2 AGT
8 canonical glycolysis GO:0061621 9.62 PGK1 GAPDH
9 vasodilation GO:0042311 9.61 AGTR2 AGT
10 regulation of blood vessel diameter GO:0097746 9.61 AGTR2 AGTR1
11 regulation of vasoconstriction GO:0019229 9.6 AGTR1 AGT
12 cellular sodium ion homeostasis GO:0006883 9.59 AGTR2 AGT
13 positive regulation of blood vessel diameter GO:0097755 9.58 AGTR2 AGT
14 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.57 AGTR1 AGT
15 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.56 AGTR2 AGT
16 nitric oxide mediated signal transduction GO:0007263 9.55 AGTR2 AGT
17 low-density lipoprotein particle remodeling GO:0034374 9.52 AGTR1 AGT
18 cell growth involved in cardiac muscle cell development GO:0061049 9.51 AGTR2 AGT
19 positive regulation of cellular protein metabolic process GO:0032270 9.49 AGTR1 AGT
20 positive regulation of renal sodium excretion GO:0035815 9.48 AGTR2 AGT
21 angiotensin-activated signaling pathway GO:0038166 9.46 AGTR2 AGTR1
22 positive regulation of cholesterol esterification GO:0010873 9.43 AGTR1 AGT
23 positive regulation of NAD(P)H oxidase activity GO:0033864 9.4 AGTR1 AGT
24 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.37 AGTR1 AGT
25 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.32 AGTR2 AGT
26 regulation of renal sodium excretion GO:0035813 9.26 AGTR1 AGT
27 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.16 AGTR1 AGT
28 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199 8.96 AGTR2 AGT
29 renin-angiotensin regulation of aldosterone production GO:0002018 8.8 AGTR2 AGTR1 AGT

Molecular functions related to Plantar Fascial Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.16 COL3A1 COL1A1
2 platelet-derived growth factor binding GO:0048407 8.96 COL3A1 COL1A1
3 angiotensin type II receptor activity GO:0004945 8.62 AGTR2 AGTR1
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Sources for Plantar Fascial Fibromatosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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