MCID: PLN001
MIFTS: 33

Plantar Wart

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Plantar Wart

MalaCards integrated aliases for Plantar Wart:

Name: Plantar Wart 12 15 17 70
Verruca Plantaris 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13775
ICD9CM 34 078.12
NCIt 50 C26913
SNOMED-CT 67 154363006
ICD10 32 B07.0
UMLS 70 C0042548

Summaries for Plantar Wart

Disease Ontology : 12 A viral infectious disease that results in benign epithelial tumors located in skin of the sole or toes of the foot, has material basis in human papillomavirus (types 1, 2, 4 or 63), has symptom lesions that appear on the sole of the foot.

MalaCards based summary : Plantar Wart, also known as verruca plantaris, is related to squamous cell papilloma and papilloma, and has symptoms including lesions An important gene associated with Plantar Wart is APOBEC3H (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3H), and among its related pathways/superpathways are Human cytomegalovirus infection and Formation of the Editosome. The drugs Imiquimod and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include skin of the sole and skin.

Wikipedia : 73 A plantar wart, or verruca, is a wart occurring on the bottom of the foot or toes. Its color is... more...

Related Diseases for Plantar Wart

Graphical network of the top 20 diseases related to Plantar Wart:



Diseases related to Plantar Wart

Symptoms & Phenotypes for Plantar Wart

Symptoms:

12
  • lesions

Drugs & Therapeutics for Plantar Wart

Drugs for Plantar Wart (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
2
Fluorouracil Approved Phase 4 51-21-8 3385
3 Analgesics, Non-Narcotic Phase 4
4 Analgesics Phase 4
5 Antirheumatic Agents Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Anti-Inflammatory Agents, Non-Steroidal Phase 4
8 Salicylates Phase 4
9 Cyclooxygenase Inhibitors Phase 4
10 Adjuvants, Immunologic Phase 4
11 Immunologic Factors Phase 4
12 Immunosuppressive Agents Phase 4
13 Antimetabolites Phase 4
14 interferons Phase 4
15
Ethanol Approved Phase 2, Phase 3 64-17-5 702
16
Salicylic acid Approved, Investigational, Vet_approved Phase 2, Phase 3 69-72-7 338
17
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
18
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
19
Petrolatum Approved, Investigational Phase 2, Phase 3 8009-03-8
20 Dermatologic Agents Phase 2, Phase 3
21 pyruvate Phase 2, Phase 3
22 Keratolytic Agents Phase 2, Phase 3
23 Anti-Infective Agents Phase 2, Phase 3
24 Antifungal Agents Phase 2, Phase 3
25 Pharmaceutical Solutions Phase 3
26 Vaccines Phase 3
27
Prilocaine Approved 721-50-6 4906
28
Lidocaine Approved, Vet_approved 137-58-6 3676
29
Nitrous oxide Approved, Vet_approved 10024-97-2 948
30
Zinc Approved, Investigational 7440-66-6 32051
31
Adapalene Approved Early Phase 1 106685-40-9 60164
32 Anti-Arrhythmia Agents
33 Sodium Channel Blockers
34 Anesthetics
35 Lidocaine, Prilocaine Drug Combination
36 Anesthetics, Local
37 Diuretics, Potassium Sparing

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Comparison of Occlusive Dressings, Salicylate Ointment, Cryotherapy, Topical 5-fluoro-uracil and Imiquimod in Immunocompetent Patients Presenting Plantar Warts in Office-based Settings: a Randomized Clinical Trial Terminated NCT01059110 Phase 4 Salicylate ointment;Imiquimod;5-Fluoro-Uracil;Cryotherapy
2 Comparison of 70% Pyruvic Acid Solution and Duofilm Solution in Treatment of Plantar Wart Unknown status NCT02151630 Phase 2, Phase 3 Pyruvic acid;Salicylic Acid
3 Efficacy of the Nonavalent HPV Vaccine in the Treatment of Difficult-to-treat Palmo-plantar Warts Not yet recruiting NCT04814446 Phase 3
4 A Phase I/II, Two- Staged Randomized, Double-blind Study to Evaluate the Safety and Efficacy of Nowarta110 in Patients With Plantar Warts and Clinical Recovery Successfully Completed Completed NCT02338336 Phase 1, Phase 2 Nowarta110;Placebo
5 A Double-Blind, Randomized, Placebo-Controlled Trial of Eutectic Lidocaine/Prilocaine Cream 5% (EMLA) for Analgesia Prior to Cryotherapy of Verrucae Plantaris in Adults Unknown status NCT01330615 EMLA;Placebo
6 Double-Blind, Randomized Control Trial To Evaluate the Efficacy of Duct Tape Versus Placebo for the Treatment of Verruca Vulgaris Completed NCT00328991
7 Clinical Trial to Demonstrate the Comparative Efficacy of a Cryogenic Treatment (Medical Device) In Common and Plantar Warts Management Completed NCT03129373
8 A Pilot Clinical Investigation in Adults to Evaluate the Safety and Performance of a Class IIa Medical Device for the Treatment of Plantar Warts (Verrucas) Completed NCT01536834
9 Cryotherapy With Liquid Nitrogen and Nitric-zinc Complex in the Treatment of Plantar Warts. Randomised Controlled Trial. Not yet recruiting NCT04654091
10 Plantar Wart Treatment Using Adapalene Gel Not yet recruiting NCT04823845 Early Phase 1 Topical Adapalene Gel 0.1%
11 Evaluation of Viral Status of Patients With Plantar Warts Included in VRAIE Study, Non-responder to Study Treatment Terminated NCT02861404

Search NIH Clinical Center for Plantar Wart

Genetic Tests for Plantar Wart

Anatomical Context for Plantar Wart

The Foundational Model of Anatomy Ontology organs/tissues related to Plantar Wart:

19
Skin Of The Sole

MalaCards organs/tissues related to Plantar Wart:

40
Skin

Publications for Plantar Wart

Articles related to Plantar Wart:

(show top 50) (show all 156)
# Title Authors PMID Year
1
Comparison of 40% trichloroacetic acid and cryotherapy for the treatment of plantar warts: A single-blind, randomized clinical trial. 61
32396250 2020
2
The application of medical scale in the treatment of plantar warts: analysis and prospect. 61
32522070 2020
3
A longstanding giant plantar wart cleared with medicinal leech application in an immunosuppressive patient. 61
31587351 2020
4
Carcinoma Cuniculatum of the Alveolar Mucosa: A Rare Variant of Squamous Cell Carcinoma. 61
29948589 2019
5
Does implantation of verruca plantaris into the abductor hallucis muscle belly in conjunction with CO2 laser ablation prevent recurrence? 61
30965226 2019
6
Amelanotic acral melanoma mimicking a plantar wart. 61
31061868 2019
7
A Nodular Lesion of the Foot Detected by 18F-FDG PET/CT in Mycosis Fungoides: A Plantar Wart. 61
30589672 2019
8
Intralesional bleomycin injection vs microneedling-assisted topical bleomycin spraying in treatment of plantar warts. 61
29687566 2019
9
Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses. 61
30909744 2019
10
Amelanotic acral melanoma misdiagnosed as verruca plantaris. 61
30726470 2019
11
Amelanotic acral melanoma misdiagnosed as verruca plantaris. 61
33131603 2019
12
A Retrospective Study of a Chinese Traditional Medicine YIKEER in the Treatment of Verruca Patients in Liaoning District. 61
31976004 2019
13
Evaluation of intralesional injection of bleomycin in the treatment of plantar warts: clinical and dermoscopic evaluation. 61
29907964 2018
14
Efficacy and Tolerability of Topical Green Tea Extract (Polyphenon E) Application in a "Therapy-Resistant" Plantar Wart. 61
29928201 2018
15
Correction: Granulomatous hepatitis in a healthy adult after bacillus Calmette-Guerin injection into a plantar wart. 61
30886883 2018
16
The Ring Verruca Plantaris in Cantharidin Use A Case Report. 61
29634299 2018
17
Not a simple plantar wart: a case of tungiasis. 61
28924985 2018
18
Plantar Warts: Epidemiology, Pathophysiology, and Clinical Management. 61
29379975 2018
19
Granulomatous hepatitis in a healthy adult after bacillus Calmette-Guérin injection into a plantar wart. 61
29159252 2017
20
Plantar wart-like Candida granuloma in a patient with myelodysplastic syndrome. 61
28636100 2017
21
A Persistent Plantar Wart Treated With a 532-nm Potassium Titanyl Phosphate Laser. 61
28157729 2017
22
Dermatological comorbidity in psoriasis: results from a large-scale cohort of employees. 61
28405739 2017
23
Human papillomaviruses genotyping in plantar warts. 61
27736001 2017
24
The Successful Use of a Novel Microwave Device in the Treatment of a Plantar Wart. 61
29033812 2017
25
Treatment of Athlete's Plantar Warts Using a Botanical Blend: A Case Report. 61
28236614 2017
26
Acral manifestations of viral infections. 61
27938811 2017
27
An Unusual Presentation of Verrucous Carcinoma of the Foot with Bone Invasion. 61
28033059 2016
28
Safety and effectiveness of cantharidin-podophylotoxin-salicylic acid in the treatment of recalcitrant plantar warts. 61
27072919 2016
29
Tandem repeats of TSER significantly influence the efficacy of 5-fluorouracil in the treatment of plantar warts. 61
29767611 2016
30
Incidences of malignancy in chronic burn scar ulcers: experience from Bangladesh. 61
25716761 2015
31
Intralesional cidofovir for the treatment of a plantar wart. 61
26089066 2015
32
Monochloroacetic acid application is an effective alternative to cryotherapy for common and plantar warts in primary care: a randomized controlled trial. 61
25584800 2015
33
Evaluating the success of Nd: YAG laser ablation in the treatment of recalcitrant verruca plantaris and a cautionary note about local anaesthesia on the plantar aspect of the foot. 61
24910163 2015
34
Topical adapalene in the treatment of plantar warts; randomized comparative open trial in comparison with cryo-therapy. 61
25657417 2015
35
A Double-Blind, Randomised, Placebo-Controlled Trial of EMLA® Cream (Eutectic Lidocaine/Prilocaine Cream) for Analgesia Prior to Cryotherapy of Plantar Warts in Adults. 61
25434622 2014
36
Human papillomavirus-related verrucous carcinoma in a renal transplant patient after long-term immunosuppression: a case report. 61
25380950 2014
37
Verrucous carcinoma of the foot, not your typical plantar wart: a case study. 61
24810296 2014
38
Human papillomavirus types 2, 27, and 57 Identified in plantar verrucae from HIV-positive and HIV-negative individuals. 61
24725033 2014
39
Plantar wart with parallel ridge pattern in a patient with a previous history of melanoma: a diagnostic challenge. 61
23905982 2013
40
A rapidly regressed giant plantar wart following biopsy. 61
23463832 2013
41
Assessment of the efficacy of a new formulation for plantar wart mummification: new experimental design and human papillomavirus identification. 61
23252755 2013
42
Phaeohyphomycosis caused by Pyrenochaeta romeroi mimicking a plantar wart in a kidney transplant recipient. 61
23121654 2012
43
The effect of patients' preference on outcome in the EVerT cryotherapy versus salicylic acid for the treatment of plantar warts (verruca) trial. 61
23146114 2012
44
Successful treatment of plantar warts with very diluted bleomycin using a translesional multipuncture technique: pilot prospective study. 61
22784517 2012
45
Cryotherapy versus salicylic acid for the treatment of plantar warts (verrucae): a randomised controlled trial. 61
21652750 2011
46
More than a plantar wart. 61
20394014 2010
47
Anatomical detection of inflammatory changes associated with plantar warts by ultrasound. 61
20185891 2010
48
Primary hyperhidrosis increases the risk of cutaneous infection: a case-control study of 387 patients. 61
19395123 2009
49
Sonography of plantar warts: role in diagnosis and treatment. 61
19470819 2009
50
The use of dermoscopy for the diagnosis of plantar wart. 61
19309426 2009

Variations for Plantar Wart

Expression for Plantar Wart

Search GEO for disease gene expression data for Plantar Wart.

Pathways for Plantar Wart

Pathways related to Plantar Wart according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.06 APOBEC3H APOBEC3C APOBEC3A AP1S1
2
Show member pathways
10.26 APOBEC3H APOBEC3C APOBEC3A

GO Terms for Plantar Wart

Cellular components related to Plantar Wart according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-body GO:0000932 8.8 APOBEC3H APOBEC3C APOBEC3A

Biological processes related to Plantar Wart according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.58 APOBEC3H APOBEC3C APOBEC3A
2 negative regulation of transposition GO:0010529 9.54 APOBEC3H APOBEC3C APOBEC3A
3 DNA demethylation GO:0080111 9.5 APOBEC3H APOBEC3C APOBEC3A
4 negative regulation of viral genome replication GO:0045071 9.43 APOBEC3C APOBEC3A
5 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045869 9.43 APOBEC3H APOBEC3C APOBEC3A
6 cytidine to uridine editing GO:0016554 9.33 APOBEC3H APOBEC3C APOBEC3A
7 cytidine deamination GO:0009972 9.13 APOBEC3H APOBEC3C APOBEC3A
8 DNA cytosine deamination GO:0070383 8.8 APOBEC3H APOBEC3C APOBEC3A

Molecular functions related to Plantar Wart according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.65 POLR1H NFX1 APOBEC3H APOBEC3C APOBEC3A
2 mechanosensitive ion channel activity GO:0008381 9.16 TMC8 TMC6
3 cytidine deaminase activity GO:0004126 9.13 APOBEC3H APOBEC3C APOBEC3A
4 deoxycytidine deaminase activity GO:0047844 8.8 APOBEC3H APOBEC3C APOBEC3A

Sources for Plantar Wart

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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