MCID: PLS032
MIFTS: 17

Plasmodium Falciparum Blood Infection Level

Categories: Blood diseases

Aliases & Classifications for Plasmodium Falciparum Blood Infection Level

MalaCards integrated aliases for Plasmodium Falciparum Blood Infection Level:

Name: Plasmodium Falciparum Blood Infection Level 57
Malaria, Intensity of Infection 57 13
Plasmodium Falciparum Parasitemia 57
Pfbi 57

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
plasmodium falciparum blood infection level:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 57 248310
MedGen 42 C1855456
SNOMED-CT via HPO 69 258211005

Summaries for Plasmodium Falciparum Blood Infection Level

MalaCards based summary : Plasmodium Falciparum Blood Infection Level, also known as malaria, intensity of infection, is related to malaria. An important gene associated with Plasmodium Falciparum Blood Infection Level is PFBI (Plasmodium Falciparum Blood Infection Levels). The drugs Azithromycin and Piperaquine have been mentioned in the context of this disorder. Affiliated tissues include liver.

Description from OMIM: 248310

Related Diseases for Plasmodium Falciparum Blood Infection Level

Diseases related to Plasmodium Falciparum Blood Infection Level via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 malaria 10.3

Symptoms & Phenotypes for Plasmodium Falciparum Blood Infection Level

Symptoms via clinical synopsis from OMIM:

57
Misc:
malarial infection intensity


Clinical features from OMIM:

248310

Drugs & Therapeutics for Plasmodium Falciparum Blood Infection Level

Drugs for Plasmodium Falciparum Blood Infection Level (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
2
Piperaquine Approved, Investigational Phase 4 4085-31-8 5079497
3
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
4
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
6
leucovorin Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-05-9 143 6006
7 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
8 Antimalarials Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
9 Antiparasitic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
10 Antiprotozoal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
11 Fanasil, pyrimethamine drug combination Phase 4
12 Folic Acid Antagonists Phase 4,Phase 1,Phase 2
13 Renal Agents Phase 4,Phase 1,Phase 2
14 Vitamin B Complex Phase 4,Phase 1,Phase 2
15 Folate Nutraceutical Phase 4,Phase 1,Phase 2
16 Vitamin B9 Nutraceutical Phase 4,Phase 1,Phase 2
17
Amodiaquine Approved, Investigational Phase 3 86-42-0 2165
18
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
19 Anthelmintics Phase 3,Not Applicable
20 Analgesics Phase 3
21 Analgesics, Non-Narcotic Phase 3
22 Anti-Inflammatory Agents Phase 3
23 Anti-Inflammatory Agents, Non-Steroidal Phase 3
24 Antirheumatic Agents Phase 3
25 Chloroquine diphosphate Phase 3 50-63-5
26 Peripheral Nervous System Agents Phase 3
27
Efavirenz Approved, Investigational Phase 1, Phase 2 154598-52-4 64139
28
Emtricitabine Approved, Investigational Phase 1, Phase 2 143491-57-0 60877
29
Lopinavir Approved Phase 1, Phase 2 192725-17-0 92727
30
Nevirapine Approved Phase 1, Phase 2 129618-40-2 4463
31
Ritonavir Approved, Investigational Phase 1, Phase 2 155213-67-5 392622
32
Sulfamethoxazole Approved Phase 1, Phase 2 723-46-6 5329
33
Trimethoprim Approved, Vet_approved Phase 1, Phase 2 738-70-5 5578
34
Heparin Approved, Investigational Phase 1, Phase 2 9005-49-6 772 46507594
35
Serine Approved, Nutraceutical Phase 1, Phase 2 56-45-1 5951
36 Anti-HIV Agents Phase 1, Phase 2
37 Anti-Retroviral Agents Phase 1, Phase 2
38 Antiviral Agents Phase 1, Phase 2
39 Cytochrome P-450 CYP2C9 Inhibitors Phase 1, Phase 2
40 Cytochrome P-450 CYP3A Inducers Phase 1, Phase 2
41 Cytochrome P-450 CYP3A Inhibitors Phase 1, Phase 2
42 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
43 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 1, Phase 2
44 HIV Protease Inhibitors Phase 1, Phase 2,Phase 2
45 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
46
protease inhibitors Phase 1, Phase 2,Phase 2
47 Reverse Transcriptase Inhibitors Phase 1, Phase 2
48
Tenofovir Phase 1, Phase 2 147127-20-6 464205
49 Vaccines Phase 2,Phase 1
50 Anticoagulants Phase 1, Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 A Safety, Tolerability, Pharmacokinetic and Efficacy Study of Azithromycin Plus Piperaquine as Presumptive Treatment in Pregnant PNG Women Unknown status NCT02575755 Phase 4 Azithromycin plus piperaquine phosphate;Sulfadoxine-pyrimethamine
2 Accelerating the Reduction of Malaria Transmission in Kanel, Ranérou and Linguère Districts Completed NCT02536222 Phase 4
3 Study of the Impact of Intermittent Preventive Treatment in Schools on Malaria, Anaemia and Education. Completed NCT00142246 Phase 3 Intermittent preventive treatment (SP and amodiaquine)
4 Evaluate Parasitological Clearance Rates And Pharmacokinetics Of The Combination Of Azithromycin And Chloroquine In Asymptomatic Pregnant Women With Falciparum Parasitemia In Africa Terminated NCT01103713 Phase 3 Azithromycin plus chloroquine
5 Comparing PI-Based to a nNRTI-based ART for Clearance of Plasmodium Falciparum Parasitemia in HIV-Infected Completed NCT01632891 Phase 1, Phase 2 Lopinavir/ritonavir;Emtricitabine/tenofovir disoproxil fumarate;Efavirenz;Nevirapine;Efavirenz;Nevirapine;Nevirapine;emtricitabine/tenofovir disoproxil fumarate;trimethoprim/sulfamethoxazole
6 Efficacy, Safety and Immunogenicity Study of GlaxoSmithKline(GSK) Biologicals' Candidate Malaria Vaccine 257049 in the Sporozoite Challenge Model in Healthy Malaria-naïve Adults Completed NCT01857869 Phase 2
7 A Safety and Efficacy Study of ChAdOx1 LS2 and MVA LS2 Completed NCT03203421 Phase 1, Phase 2
8 Safety, Immunogenicity and Efficacy Against of a Combined Malaria Vaccine in Healthy Malaria-naïve Adults Completed NCT01366534 Phase 2
9 Epidemiology Study of Malaria Transmission Intensity in Africa Completed NCT01190202
10 School-based Programme of Malaria Diagnosis and Treatment in Southern Malawi Completed NCT02213211 Not Applicable Artemether lumefantrine
11 Hyperphenylalaninemia in Cerebral Malaria Completed NCT00338520

Search NIH Clinical Center for Plasmodium Falciparum Blood Infection Level

Genetic Tests for Plasmodium Falciparum Blood Infection Level

Anatomical Context for Plasmodium Falciparum Blood Infection Level

MalaCards organs/tissues related to Plasmodium Falciparum Blood Infection Level:

41
Liver

Publications for Plasmodium Falciparum Blood Infection Level

Articles related to Plasmodium Falciparum Blood Infection Level:

# Title Authors Year
1
Genetic association of Toll-like-receptor 4 and tumor necrosis factor-alpha polymorphisms with Plasmodium falciparum blood infection levels. ( 20307689 )
2010

Variations for Plasmodium Falciparum Blood Infection Level

Expression for Plasmodium Falciparum Blood Infection Level

Search GEO for disease gene expression data for Plasmodium Falciparum Blood Infection Level.

Pathways for Plasmodium Falciparum Blood Infection Level

GO Terms for Plasmodium Falciparum Blood Infection Level

Sources for Plasmodium Falciparum Blood Infection Level

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....