PFBI
MCID: PLS032
MIFTS: 17

Plasmodium Falciparum Blood Infection Level (PFBI)

Categories: Blood diseases

Aliases & Classifications for Plasmodium Falciparum Blood Infection Level

MalaCards integrated aliases for Plasmodium Falciparum Blood Infection Level:

Name: Plasmodium Falciparum Blood Infection Level 57
Malaria, Intensity of Infection 57 13
Plasmodium Falciparum Parasitemia 57
Pfbi 57

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
plasmodium falciparum blood infection level:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 57 248310
MedGen 42 C1855456
SNOMED-CT via HPO 69 258211005

Summaries for Plasmodium Falciparum Blood Infection Level

MalaCards based summary : Plasmodium Falciparum Blood Infection Level, also known as malaria, intensity of infection, is related to malaria. An important gene associated with Plasmodium Falciparum Blood Infection Level is PFBI (Plasmodium Falciparum Blood Infection Levels). The drugs Pyrimethamine and leucovorin have been mentioned in the context of this disorder.

Description from OMIM: 248310

Related Diseases for Plasmodium Falciparum Blood Infection Level

Diseases related to Plasmodium Falciparum Blood Infection Level via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 malaria 10.4

Symptoms & Phenotypes for Plasmodium Falciparum Blood Infection Level

Symptoms via clinical synopsis from OMIM:

57
Misc:
malarial infection intensity


Clinical features from OMIM:

248310

Drugs & Therapeutics for Plasmodium Falciparum Blood Infection Level

Drugs for Plasmodium Falciparum Blood Infection Level (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
2
leucovorin Approved Phase 4,Phase 1,Phase 2 58-05-9 6006 143
3
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
4
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
6
Piperaquine Experimental, Investigational Phase 4 4085-31-8 5079497
7 Folate Phase 4,Phase 1,Phase 2
8 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
9 Anti-Infective Agents, Urinary Phase 4,Phase 1,Phase 2
10 Vitamin B9 Phase 4,Phase 1,Phase 2
11 Vitamin B Complex Phase 4,Phase 1,Phase 2
12 Folic Acid Antagonists Phase 4,Phase 1,Phase 2
13 Antiparasitic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Antiprotozoal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
15 Fanasil, pyrimethamine drug combination Phase 4
16 Antimalarials Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
17 Renal Agents Phase 4,Phase 1,Phase 2
18
Amodiaquine Approved, Investigational Phase 3 86-42-0 2165
19
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
20 Anthelmintics Phase 3,Not Applicable
21 Anti-Inflammatory Agents Phase 3
22 Chloroquine diphosphate Phase 3 50-63-5
23 Anti-Inflammatory Agents, Non-Steroidal Phase 3
24 Analgesics Phase 3
25 Peripheral Nervous System Agents Phase 3
26 Antirheumatic Agents Phase 3
27 Analgesics, Non-Narcotic Phase 3
28
Efavirenz Approved, Investigational Phase 1, Phase 2 154598-52-4 64139
29
Lopinavir Approved Phase 1, Phase 2 192725-17-0 92727
30
Sulfamethoxazole Approved Phase 1, Phase 2 723-46-6 5329
31
Emtricitabine Approved, Investigational Phase 1, Phase 2 143491-57-0 60877
32
Trimethoprim Approved, Vet_approved Phase 1, Phase 2 738-70-5 5578
33
Ritonavir Approved, Investigational Phase 1, Phase 2 155213-67-5 392622
34
Nevirapine Approved Phase 1, Phase 2 129618-40-2 4463
35
Heparin Approved, Investigational Phase 1, Phase 2 9005-49-6 772 46507594
36
Serine Approved, Nutraceutical Phase 1, Phase 2 56-45-1 5951
37
Tenofovir Experimental, Investigational Phase 1, Phase 2 147127-20-6 464205
38 Cytochrome P-450 CYP2C19 Inhibitors Phase 1, Phase 2
39
protease inhibitors Phase 1, Phase 2,Phase 2
40 Anti-HIV Agents Phase 1, Phase 2
41 Antiviral Agents Phase 1, Phase 2
42 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
43 Reverse Transcriptase Inhibitors Phase 1, Phase 2
44 HIV Protease Inhibitors Phase 1, Phase 2,Phase 2
45 Cytochrome P-450 CYP3A Inducers Phase 1, Phase 2
46 Anti-Retroviral Agents Phase 1, Phase 2
47 Cytochrome P-450 CYP3A Inhibitors Phase 1, Phase 2
48 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 1, Phase 2
49 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
50 Cytochrome P-450 CYP2C9 Inhibitors Phase 1, Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 A Safety, Tolerability, Pharmacokinetic and Efficacy Study of Azithromycin Plus Piperaquine as Presumptive Treatment in Pregnant PNG Women Unknown status NCT02575755 Phase 4 Azithromycin plus piperaquine phosphate;Sulfadoxine-pyrimethamine
2 Accelerating the Reduction of Malaria Transmission in Kanel, Ranérou and Linguère Districts Completed NCT02536222 Phase 4
3 Study of the Impact of Intermittent Preventive Treatment in Schools on Malaria, Anaemia and Education. Completed NCT00142246 Phase 3 Intermittent preventive treatment (SP and amodiaquine)
4 Evaluate Parasitological Clearance Rates And Pharmacokinetics Of The Combination Of Azithromycin And Chloroquine In Asymptomatic Pregnant Women With Falciparum Parasitemia In Africa Terminated NCT01103713 Phase 3 Azithromycin plus chloroquine
5 Comparing PI-Based to a nNRTI-based ART for Clearance of Plasmodium Falciparum Parasitemia in HIV-Infected Completed NCT01632891 Phase 1, Phase 2 Lopinavir/ritonavir;Emtricitabine/tenofovir disoproxil fumarate;Efavirenz;Nevirapine;Efavirenz;Nevirapine;Nevirapine;emtricitabine/tenofovir disoproxil fumarate;trimethoprim/sulfamethoxazole
6 Efficacy, Safety and Immunogenicity Study of GlaxoSmithKline(GSK) Biologicals' Candidate Malaria Vaccine 257049 in the Sporozoite Challenge Model in Healthy Malaria-naïve Adults Completed NCT01857869 Phase 1, Phase 2
7 A Safety and Efficacy Study of ChAdOx1 LS2 and MVA LS2 Completed NCT03203421 Phase 1, Phase 2
8 Safety, Immunogenicity and Efficacy Against of a Combined Malaria Vaccine in Healthy Malaria-naïve Adults Completed NCT01366534 Phase 2
9 Epidemiology Study of Malaria Transmission Intensity in Africa Completed NCT01190202
10 School-based Programme of Malaria Diagnosis and Treatment in Southern Malawi Completed NCT02213211 Not Applicable Artemether lumefantrine
11 Hyperphenylalaninemia in Cerebral Malaria Completed NCT00338520

Search NIH Clinical Center for Plasmodium Falciparum Blood Infection Level

Genetic Tests for Plasmodium Falciparum Blood Infection Level

Anatomical Context for Plasmodium Falciparum Blood Infection Level

Publications for Plasmodium Falciparum Blood Infection Level

Articles related to Plasmodium Falciparum Blood Infection Level:

# Title Authors Year
1
Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia. ( 25712976 )
2015
2
Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women. ( 20926522 )
2010
3
Elevated levels of soluble TNF receptors 1 and 2 correlate with Plasmodium falciparum parasitemia in pregnant women: potential markers for malaria-associated inflammation. ( 20980627 )
2010
4
Family-based association of a low producing lymphotoxin-alpha allele with reduced Plasmodium falciparum parasitemia. ( 18457972 )
2008
5
A novel semi-automatic image processing approach to determine Plasmodium falciparum parasitemia in Giemsa-stained thin blood smears. ( 18373862 )
2008
6
IL12B polymorphisms are linked but not associated with Plasmodium falciparum parasitemia: a familial study in Burkina Faso. ( 18449199 )
2008
7
Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. ( 14573655 )
2003
8
Assessment of the effect of the oral iron chelator deferiprone on asymptomatic Plasmodium falciparum parasitemia in humans. ( 9546419 )
1998
9
Immunoglobulin G reactivities to rhoptry-associated protein-1 associated with decreased levels of Plasmodium falciparum parasitemia in Tanzanian children. ( 9025691 )
1996

Variations for Plasmodium Falciparum Blood Infection Level

Expression for Plasmodium Falciparum Blood Infection Level

Search GEO for disease gene expression data for Plasmodium Falciparum Blood Infection Level.

Pathways for Plasmodium Falciparum Blood Infection Level

GO Terms for Plasmodium Falciparum Blood Infection Level

Sources for Plasmodium Falciparum Blood Infection Level

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69 SNOMED-CT via HPO
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71 TGDB
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74 UMLS via Orphanet
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