PFBI
MCID: PLS032
MIFTS: 22

Plasmodium Falciparum Blood Infection Level (PFBI)

Categories: Blood diseases

Aliases & Classifications for Plasmodium Falciparum Blood Infection Level

MalaCards integrated aliases for Plasmodium Falciparum Blood Infection Level:

Name: Plasmodium Falciparum Blood Infection Level 56
Plasmodium Falciparum Blood Infection Levels 13
Plasmodium Falciparum Parasitemia 56
Malaria, Intensity of Infection 56
Pfbi 56

Characteristics:

OMIM:

56
Inheritance:
autosomal recessive


HPO:

31
plasmodium falciparum blood infection level:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 56 248310
MedGen 41 C1855456
SNOMED-CT via HPO 68 258211005

Summaries for Plasmodium Falciparum Blood Infection Level

MalaCards based summary : Plasmodium Falciparum Blood Infection Level, also known as plasmodium falciparum blood infection levels, is related to malaria and plasmodium falciparum malaria. An important gene associated with Plasmodium Falciparum Blood Infection Level is PFBI (Plasmodium Falciparum Blood Infection Levels). The drugs Azithromycin and chloroquine have been mentioned in the context of this disorder. Affiliated tissues include testes, placenta and endothelial.

More information from OMIM: 248310

Related Diseases for Plasmodium Falciparum Blood Infection Level

Diseases related to Plasmodium Falciparum Blood Infection Level via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 malaria 10.3
2 plasmodium falciparum malaria 10.3
3 ocular motor apraxia 10.2
4 malaria, mild 10.2
5 deficiency anemia 10.2
6 iron deficiency anemia 10.2
7 hemosiderosis 10.2
8 neutropenia 10.2
9 thrombocytopenia 10.2
10 iron metabolism disease 10.2
11 hemoglobin c disease 10.2
12 splenomegaly 10.2
13 rare hereditary hemochromatosis 10.2

Graphical network of the top 20 diseases related to Plasmodium Falciparum Blood Infection Level:



Diseases related to Plasmodium Falciparum Blood Infection Level

Symptoms & Phenotypes for Plasmodium Falciparum Blood Infection Level

Symptoms via clinical synopsis from OMIM:

56
Misc:
malarial infection intensity

Clinical features from OMIM:

248310

Drugs & Therapeutics for Plasmodium Falciparum Blood Infection Level

Drugs for Plasmodium Falciparum Blood Infection Level (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 3 83905-01-5 55185 447043
2
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
3 Analgesics Phase 3
4 Anti-Infective Agents Phase 3
5 Analgesics, Non-Narcotic Phase 3
6 Antiparasitic Agents Phase 3
7 Anti-Inflammatory Agents, Non-Steroidal Phase 3
8 Antiprotozoal Agents Phase 3
9 Antimalarials Phase 3
10 Anti-Inflammatory Agents Phase 3
11 Chloroquine diphosphate Phase 3 50-63-5
12 Antirheumatic Agents Phase 3
13 Anthelmintics Phase 3
14
Phenylalanine Approved, Investigational, Nutraceutical 63-91-2 6140

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open Label, Non-comparative Study To Evaluate Parasitological Clearance Rates And Pharmacokinetics Of Azithromycin And Chloroquine Following Administration Of A Fixed Dose Combination Of Azithromycin And Chloroquine (Azcq) In Asymptomatic Pregnant Women With Plasmodium Falciparum Parasitemia In Sub-saharan Africa Terminated NCT01103713 Phase 3 Azithromycin plus chloroquine
2 Hyperphenylalaninemia in Cerebral Malaria Completed NCT00338520

Search NIH Clinical Center for Plasmodium Falciparum Blood Infection Level

Genetic Tests for Plasmodium Falciparum Blood Infection Level

Anatomical Context for Plasmodium Falciparum Blood Infection Level

MalaCards organs/tissues related to Plasmodium Falciparum Blood Infection Level:

40
Testes, Placenta, Endothelial

Publications for Plasmodium Falciparum Blood Infection Level

Articles related to Plasmodium Falciparum Blood Infection Level:

(show top 50) (show all 107)
# Title Authors PMID Year
1
Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human Chromosome 5q31-q33. 56
15118851 2004
2
Linkage and association between Plasmodium falciparum blood infection levels and chromosome 5q31-q33. 56
12761562 2003
3
Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31-q33. 56
9683598 1998
4
Linkage analysis of blood Plasmodium falciparum levels: interest of the 5q31-q33 chromosome region. 56
9660449 1998
5
Segregation analysis detects a major gene controlling blood infection levels in human malaria. 56
1598911 1992
6
Impact of Microscopic and Submicroscopic Parasitemia During Pregnancy on Placental Malaria in a High-Transmission Setting in Uganda. 61
30891605 2019
7
Plasmodium falciparum Parasitemia and Band Sensitivity of the SD Bioline Malaria Ag P.f/Pan Rapid Diagnostic Test in Madagascar. 61
30834883 2019
8
Transmission and Age Impact the Risk of Developing Febrile Malaria in Children with Asymptomatic Plasmodium falciparum Parasitemia. 61
30307567 2019
9
A validation study of microscopy versus quantitative PCR for measuring Plasmodium falciparum parasitemia. 61
31485189 2019
10
Erythrocyte Lipid and Antioxidant Changes in <i>Plasmodium falciparum</i>-infected Children Attending Mother and Child Hospital in Akure, Nigeria. 61
31930848 2019
11
Measuring malaria morbidity in an area of seasonal transmission: Pyrogenic parasitemia thresholds based on a 20-year follow-up study. 61
31246965 2019
12
High prevalence of dihydrofolate reductase gene mutations in Plasmodium falciparum parasites among pregnant women in Nigeria after reported use of sulfadoxine-pyrimethamine. 61
29318942 2018
13
High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda. 61
28362936 2017
14
Simultaneous assessment of iodine, iron, vitamin A, malarial antigenemia, and inflammation status biomarkers via a multiplex immunoassay method on a population of pregnant women from Niger. 61
28982133 2017
15
Increased Plasmodium falciparum Parasitemia in Non-splenectomized Saimiri sciureus Monkeys Treated with Clodronate Liposomes. 61
28983468 2017
16
Estimation of Plasmodium falciparum Transmission Intensity in Lilongwe, Malawi, by Microscopy, Rapid Diagnostic Testing, and Nucleic Acid Detection. 61
27325802 2016
17
Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda. 61
27197604 2016
18
Effect of HIV-1 Serostatus on the Prevalence of Asymptomatic Plasmodium falciparum Parasitemia Among Children Less Than 5 Years of Age in Benin City, Nigeria. 61
26908488 2016
19
Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub-Saharan Africa. 61
27861509 2016
20
[Splenomegaly in an Eritrean refugee: the hyper-reactive malaria splenomegaly syndrome.] 61
27848905 2016
21
Cerebral Malaria: An Unusual Cause of Central Diabetes Insipidus. 61
27242936 2016
22
Steroid Pulse Therapy May Mitigate Prolonged Neurological Manifestations after Eradication of Severe Plasmodium falciparum Parasitemia. 61
27853090 2016
23
Elevated Blood Lead Levels Are Associated with Reduced Risk of Malaria in Beninese Infants. 61
26866471 2016
24
Novel Insights Into the Protective Role of Hemoglobin S and C Against Plasmodium falciparum Parasitemia. 61
25712976 2015
25
Population pharmacokinetics, tolerability, and safety of dihydroartemisinin-piperaquine and sulfadoxine-pyrimethamine-piperaquine in pregnant and nonpregnant Papua New Guinean women. 61
25963981 2015
26
Erratum for Cercamondi et al. Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women. Am J Clin Nutr 2010;92:1385-92. 61
25833990 2015
27
Plasma concentration of parasite DNA as a measure of disease severity in falciparum malaria. 61
25344520 2015
28
Genome-level determination of Plasmodium falciparum blood-stage targets of malarial clinical immunity in the Peruvian Amazon. 61
25381370 2015
29
Duration of vaccine efficacy against malaria: 5th year of follow-up in children vaccinated with RTS,S/AS02 in Mozambique. 61
24631081 2014
30
Recombinant scorpine produced using SUMO fusion partner in Escherichia coli has the activities against clinically isolated bacteria and inhibits the Plasmodium falciparum parasitemia in vitro. 61
25068263 2014
31
Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence. 61
23945376 2013
32
Genetic characterization of Plasmodium falciparum allelic variants infecting mothers at delivery and their children during their first plasmodial infections. 61
23932959 2013
33
Impact of asymptomatic Plasmodium falciparum parasitemia on the imunohematological indices among school children and adolescents in a rural area highly endemic for malaria in southern Mozambique. 61
23710648 2013
34
Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure. 61
23514288 2013
35
VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placenta. 61
23936092 2013
36
The effect of HIV infection on the risk, frequency, and intensity of Plasmodium falciparum parasitemia in primigravid and multigravid women in Malawi. 61
23045249 2012
37
Effect of HIV infection and Plasmodium falciparum parasitemia on pregnancy outcomes in Malawi. 61
22764288 2012
38
Evidence of Endothelial Activation in Asymptomatic Plasmodium falciparum Parasitemia and Effect of Blood Group on Levels of von Willebrand Factor in Malaria. 61
23687570 2012
39
Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: a retrospective case-control study*. 61
22343839 2012
40
Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level. 61
23071570 2012
41
The combination of indoor residual spraying and insecticide-treated nets provides added protection against malaria compared with insecticide-treated nets alone. 61
22144448 2011
42
Redefining cerebral malaria by including malaria retinopathy. 61
21449844 2011
43
Spontaneous postpartum clearance of Plasmodium falciparum parasitemia in pregnant women, Benin. 61
21292897 2011
44
Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus. 61
20805786 2011
45
Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women. 61
20926522 2010
46
Elevated levels of soluble TNF receptors 1 and 2 correlate with Plasmodium falciparum parasitemia in pregnant women: potential markers for malaria-associated inflammation. 61
20980627 2010
47
Dynamics of Plasmodium falciparum parasitemia regarding combined treatment regimens for acute uncomplicated malaria, Antioquia, Colombia. 61
20595483 2010
48
Malaria as a cause of morbidity and mortality in children with homozygous sickle cell disease on the coast of Kenya. 61
19514855 2009
49
Influence of wasting and stunting at the onset of the rainy season on subsequent malaria morbidity among rural preschool children in Senegal. 61
19190214 2009
50
Access to essential maternal health interventions and human rights violations among vulnerable communities in eastern Burma. 61
19108601 2008

Variations for Plasmodium Falciparum Blood Infection Level

Expression for Plasmodium Falciparum Blood Infection Level

Search GEO for disease gene expression data for Plasmodium Falciparum Blood Infection Level.

Pathways for Plasmodium Falciparum Blood Infection Level

GO Terms for Plasmodium Falciparum Blood Infection Level

Sources for Plasmodium Falciparum Blood Infection Level

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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