MCID: PLS032
MIFTS: 20

Plasmodium Falciparum Blood Infection Level

Categories: Blood diseases

Aliases & Classifications for Plasmodium Falciparum Blood Infection Level

MalaCards integrated aliases for Plasmodium Falciparum Blood Infection Level:

Name: Plasmodium Falciparum Blood Infection Level 58
Plasmodium Falciparum Blood Infection Levels 13
Plasmodium Falciparum Parasitemia 58
Malaria, Intensity of Infection 58
Pfbi 58

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
plasmodium falciparum blood infection level:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 58 248310
MedGen 43 C1855456
SNOMED-CT via HPO 70 258211005

Summaries for Plasmodium Falciparum Blood Infection Level

MalaCards based summary : Plasmodium Falciparum Blood Infection Level, also known as plasmodium falciparum blood infection levels, is related to malaria and salla disease. An important gene associated with Plasmodium Falciparum Blood Infection Level is PFBI (Plasmodium Falciparum Blood Infection Levels). The drugs Azithromycin and Pyrimethamine have been mentioned in the context of this disorder.

Description from OMIM: 248310

Related Diseases for Plasmodium Falciparum Blood Infection Level

Diseases related to Plasmodium Falciparum Blood Infection Level via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 malaria 10.3
2 salla disease 10.2
3 hemoglobin c disease 10.2

Symptoms & Phenotypes for Plasmodium Falciparum Blood Infection Level

Symptoms via clinical synopsis from OMIM:

58
Misc:
malarial infection intensity

Clinical features from OMIM:

248310

Drugs & Therapeutics for Plasmodium Falciparum Blood Infection Level

Drugs for Plasmodium Falciparum Blood Infection Level (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3 83905-01-5 447043 55185
2
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
3
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
4
leucovorin Approved Phase 4,Phase 1,Phase 2 58-05-9 143 6006
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
6
Piperaquine Experimental, Investigational Phase 4 4085-31-8 5079497
7 Antimalarials Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
8 Antiparasitic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
9 Anti-Infective Agents, Urinary Phase 4,Phase 1,Phase 2
10 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
11 Folate Phase 4,Phase 1,Phase 2
12 Vitamin B9 Phase 4,Phase 1,Phase 2
13 Fanasil, pyrimethamine drug combination Phase 4
14 Vitamin B Complex Phase 4,Phase 1,Phase 2
15 Folic Acid Antagonists Phase 4,Phase 1,Phase 2
16 Antiprotozoal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
17 Renal Agents Phase 4,Phase 1,Phase 2
18
Amodiaquine Approved, Investigational Phase 3 86-42-0 2165
19
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
20 Analgesics Phase 3
21 Chloroquine diphosphate Phase 3 50-63-5
22 Analgesics, Non-Narcotic Phase 3
23 Antirheumatic Agents Phase 3
24 Anti-Inflammatory Agents Phase 3
25 Peripheral Nervous System Agents Phase 3
26 Anti-Inflammatory Agents, Non-Steroidal Phase 3
27 Anthelmintics Phase 3
28
Ritonavir Approved, Investigational Phase 1, Phase 2 155213-67-5 392622
29
Lopinavir Approved Phase 1, Phase 2 192725-17-0 92727
30
Sulfamethoxazole Approved Phase 1, Phase 2 723-46-6 5329
31
Emtricitabine Approved, Investigational Phase 1, Phase 2 143491-57-0 60877
32
Trimethoprim Approved, Vet_approved Phase 1, Phase 2 738-70-5 5578
33
Tenofovir Approved, Experimental, Investigational Phase 1, Phase 2 147127-20-6 464205
34
Nevirapine Approved Phase 1, Phase 2 129618-40-2 4463
35
Efavirenz Approved, Investigational Phase 1, Phase 2 154598-52-4 64139
36
Heparin Approved, Investigational Phase 1, Phase 2 9005-49-6 46507594 772
37
Serine Approved, Nutraceutical Phase 1, Phase 2 56-45-1 5951
38
protease inhibitors Phase 1, Phase 2,Phase 2
39 Anti-Retroviral Agents Phase 1, Phase 2
40 HIV Protease Inhibitors Phase 1, Phase 2,Phase 2
41 Anti-HIV Agents Phase 1, Phase 2
42 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2
43 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
44 Reverse Transcriptase Inhibitors Phase 1, Phase 2
45 Cytochrome P-450 CYP2C19 Inhibitors Phase 1, Phase 2
46 Cytochrome P-450 CYP2C9 Inhibitors Phase 1, Phase 2
47 Cytochrome P-450 CYP3A Inhibitors Phase 1, Phase 2
48 Antiviral Agents Phase 1, Phase 2
49 Cytochrome P-450 CYP3A Inducers Phase 1, Phase 2
50 Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Phase 1, Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Safety, Tolerability, Pharmacokinetic and Efficacy Study of Azithromycin Plus Piperaquine as Presumptive Treatment in Pregnant PNG Women Unknown status NCT02575755 Phase 4 Azithromycin plus piperaquine phosphate;Sulfadoxine-pyrimethamine
2 Accelerating the Reduction of Malaria Transmission in Kanel, Ranérou and Linguère Districts Completed NCT02536222 Phase 4
3 Study of the Impact of Intermittent Preventive Treatment in Schools on Malaria, Anaemia and Education. Completed NCT00142246 Phase 3 Intermittent preventive treatment (SP and amodiaquine)
4 Evaluate Parasitological Clearance Rates And Pharmacokinetics Of The Combination Of Azithromycin And Chloroquine In Asymptomatic Pregnant Women With Falciparum Parasitemia In Africa Terminated NCT01103713 Phase 3 Azithromycin plus chloroquine
5 Comparing PI-Based to a nNRTI-based ART for Clearance of Plasmodium Falciparum Parasitemia in HIV-Infected Completed NCT01632891 Phase 1, Phase 2 Lopinavir/ritonavir;Emtricitabine/tenofovir disoproxil fumarate;Efavirenz;Nevirapine;Trimethoprim/sulfamethoxazole
6 Efficacy, Safety and Immunogenicity Study of GlaxoSmithKline(GSK) Biologicals' Candidate Malaria Vaccine 257049 in the Sporozoite Challenge Model in Healthy Malaria-naïve Adults Completed NCT01857869 Phase 1, Phase 2
7 A Safety and Efficacy Study of ChAdOx1 LS2 and MVA LS2 Completed NCT03203421 Phase 1, Phase 2
8 Safety, Immunogenicity and Efficacy Against of a Combined Malaria Vaccine in Healthy Malaria-naïve Adults Completed NCT01366534 Phase 1, Phase 2
9 To Assess the Safety, Immunogenicity and Efficacy of VLPM01 in Healthy, Malaria-Naïve Volunteers Recruiting NCT03867331 Phase 1
10 Epidemiology Study of Malaria Transmission Intensity in Africa Completed NCT01190202
11 School-based Programme of Malaria Diagnosis and Treatment in Southern Malawi Completed NCT02213211 Not Applicable Artemether lumefantrine
12 Hyperphenylalaninemia in Cerebral Malaria Completed NCT00338520

Search NIH Clinical Center for Plasmodium Falciparum Blood Infection Level

Genetic Tests for Plasmodium Falciparum Blood Infection Level

Anatomical Context for Plasmodium Falciparum Blood Infection Level

Publications for Plasmodium Falciparum Blood Infection Level

Articles related to Plasmodium Falciparum Blood Infection Level:

# Title Authors Year
1
Genetic association of Toll-like-receptor 4 and tumor necrosis factor-alpha polymorphisms with Plasmodium falciparum blood infection levels. ( 20307689 )
2010
2
Linkage and association between Plasmodium falciparum blood infection levels and chromosome 5q31-q33. ( 12761562 )
2003
3
Genetic dissection of Plasmodium falciparum blood infection levels and other complex traits related to human malaria infection. ( 10697837 )
1999
4
Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31-q33. ( 9683598 )
1998

Variations for Plasmodium Falciparum Blood Infection Level

Expression for Plasmodium Falciparum Blood Infection Level

Search GEO for disease gene expression data for Plasmodium Falciparum Blood Infection Level.

Pathways for Plasmodium Falciparum Blood Infection Level

GO Terms for Plasmodium Falciparum Blood Infection Level

Sources for Plasmodium Falciparum Blood Infection Level

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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