Plasmodium Malariae Malaria disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Plasmodium Malariae Malaria

MalaCards integrated aliases for Plasmodium Malariae Malaria:

Name: Plasmodium Malariae Malaria ¹² ¹⁵

Quartan Malaria ¹² ⁷³

Malaria by Plasmodium Malariae ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Certain infectious and parasitic diseases

Protozoal diseases

Plasmodium malariae malaria

Plasmodium malariae malaria with nephropathy

Plasmodium malariae malaria with other complications

Plasmodium malariae malaria without complication

External Ids:

Disease Ontology ¹² DOID:14324

ICD10 ³³ B52 B52.9 B52.0 more

ICD9CM ³⁵ 084.2

NCIt ⁵⁰ C34799

SNOMED-CT ⁶⁸ 27618009

UMLS ⁷³ C0024536

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Summaries for Plasmodium Malariae Malaria

Disease Ontology : ¹² A malaria caused by a parasite Plasmodium malariae, which is marked by recurrence of paroxysms at 72-hour intervals.

MalaCards based summary : Plasmodium Malariae Malaria, also known as quartan malaria, is related to malaria and cryptosporidiosis. An important gene associated with Plasmodium Malariae Malaria is DHFR (Dihydrofolate Reductase), and among its related pathways/superpathways are One carbon pool by folate and Pyrimidine metabolism.

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Related Diseases for Plasmodium Malariae Malaria

Diseases related to Plasmodium Malariae Malaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)

#	Related Disease	Score	Top Affiliating Genes
1	malaria	30.3	ALB CD40LG DHFR TYMS
2	cryptosporidiosis	10.2	CD40LG DHFR
3	colorado tick fever	10.1	ALB CD40LG
4	cork-handlers' disease	10.1	ALB CD40LG
5	fournier gangrene	10.1	ALB CD40LG
6	yellow nail syndrome	10.1	ALB CD40LG
7	diffuse glomerulonephritis	10.1	ALB CD40LG
8	splenic disease	10.1	ALB CD40LG
9	aleutian mink disease	10.1	ALB CD40LG
10	non-secretory myeloma	10.1	ALB CD40LG
11	parasitic protozoa infectious disease	10.1	CD40LG DHFR
12	transient arthritis	10.1	ALB CD40LG
13	hypersensitivity reaction type iii disease	10.1	ALB CD40LG
14	hemorrhagic fever	10.1	ALB CD40LG
15	toxoplasmosis	10.1	CD40LG DHFR
16	legionnaires' disease	10.1	ALB CD40LG
17	autoimmune disease of urogenital tract	10.1	ALB CD40LG
18	hepatitis e	10.1	ALB CD40LG
19	hemorrhagic fever with renal syndrome	10.0	ALB CD40LG
20	meningoencephalitis	10.0	ALB CD40LG
21	hepatitis a	10.0	ALB CD40LG
22	leukocyte disease	10.0	ALB CD40LG
23	dengue hemorrhagic fever	10.0	ALB CD40LG
24	guillain-barre syndrome	10.0	ALB CD40LG
25	rabies	10.0	ALB CD40LG
26	sclerosing cholangitis	10.0	ALB CD40LG
27	primary bacterial infectious disease	10.0	ALB CD40LG
28	hypersensitivity reaction disease	10.0	ALB CD40LG
29	schistosomiasis	10.0	ALB CD40LG
30	bronchitis	10.0	ALB CD40LG
31	respiratory system disease	10.0	ALB CD40LG
32	cholangitis	9.9	ALB CD40LG
33	otitis media	9.9	ALB CD40LG
34	urinary system disease	9.9	ALB CD40LG
35	gastrointestinal system cancer	9.9	ALB TYMS
36	viral hepatitis	9.9	ALB CD40LG
37	iga glomerulonephritis	9.9	ALB CD40LG
38	acquired immunodeficiency syndrome	9.9	ALB CD40LG
39	immune system disease	9.8	ALB CD40LG
40	meningitis	9.8	ALB CD40LG
41	gastrointestinal system disease	9.8	ALB CD40LG
42	chorioretinal scar	9.7	CD40LG SAMHD1
43	urethral syndrome	9.7	CD40LG SAMHD1
44	nervous system disease	9.7	ALB CD40LG
45	celiac disease 1	9.7	ALB CD40LG
46	diarrhea	9.6	ALB CD40LG
47	pneumocystosis	9.6	ALB CD40LG DHFR
48	primary biliary cirrhosis	9.5	ALB CD40LG
49	glomerulonephritis	9.2	ALB CD40LG

Graphical network of the top 20 diseases related to Plasmodium Malariae Malaria:

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Symptoms & Phenotypes for Plasmodium Malariae Malaria

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Drugs & Therapeutics for Plasmodium Malariae Malaria

Search Clinical Trials , NIH Clinical Center for Plasmodium Malariae Malaria

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Genetic Tests for Plasmodium Malariae Malaria

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Anatomical Context for Plasmodium Malariae Malaria

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Publications for Plasmodium Malariae Malaria

Articles related to Plasmodium Malariae Malaria:

#	Title	Authors	Year
1	Plasmodium malariae Malaria: From Monkey to Man? ( 26501096 )	Rayner J.C.	2015
2	A case of imported Plasmodium malariae malaria. ( 22563561 )	Hong Y.J....Kim E.C.	2012
3	Severe Plasmodium malariae malaria in a patient with multiple susceptibility genes. ( 20536892 )	Bellanger A.P....HouzAc S.	2010
4	Plasmodium malariae malaria--a case report. ( 16498762 )	Sitalakshmi S....Damodar P.	2005
5	Imported Plasmodium malariae malaria. ( 8358132 )	Nishiyama T....Tsujii T.	1993
6	Treatment of an acute case of Plasmodium malariae malaria with mefloquine. ( 6344673 )	Dixon K.E....Na-Nakorn A.	1983

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Genes for Plasmodium Malariae Malaria

Genes related to Plasmodium Malariae Malaria (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DHFR	Dihydrofolate Reductase	Protein Coding	15.14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	TYMS	Thymidylate Synthetase	Protein Coding	14.58	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	CD40LG	CD40 Ligand	Protein Coding	14.5	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	SAMHD1	SAM And HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase 1	Protein Coding	13.97	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	ALB	Albumin	Protein Coding	13.49	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Plasmodium Malariae Malaria

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Expression for Plasmodium Malariae Malaria

Search GEO for disease gene expression data for Plasmodium Malariae Malaria.

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Pathways for Plasmodium Malariae Malaria

Pathways related to Plasmodium Malariae Malaria according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	One carbon pool by folate ³⁷ Show member pathways Antimetabolite Pathway - Folate Cycle, Pharmacodynamics ⁶¹ dTMP de novo biosynthesis (mitochondrial) ¹ folate transformations I ¹ Methionine metabolism ²² methionine salvage ¹ Methotrexate Pathway (Cancer Cell), Pharmacodynamics ⁶¹ One Carbon Metabolism ¹ tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate ¹ Trans-sulfuration and one carbon metabolism ¹	11.47	DHFR TYMS
2	Pyrimidine metabolism ⁶⁶ Show member pathways Fluoropyrimidine Activity ¹ Fluoropyrimidine Pathway, Pharmacodynamics ⁶¹ Fluoropyrimidine Pathway, Pharmacokinetics ⁶¹ glutamate removal from folates ¹ Pyrimidine biosynthesis ⁶⁶ Pyrimidine catabolism ⁶⁶ pyrimidine ribonucleosides degradation ¹ pyrimidine ribonucleosides salvage I ¹ Pyrimidine salvage reactions ⁶⁶ UMP biosynthesis ¹	11.39	DHFR TYMS
3	Retinoblastoma (RB) in Cancer ¹	11.1	DHFR TYMS
4	E2F transcription factor network ¹	10.82	DHFR TYMS
5	Antifolate resistance ³⁷	10.11	DHFR TYMS

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GO Terms for Plasmodium Malariae Malaria

Biological processes related to Plasmodium Malariae Malaria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of translation	GO:0017148	9.16	DHFR TYMS
2	regulation of transcription involved in G1/S transition of mitotic cell cycle	GO:0000083	8.96	DHFR TYMS
3	tetrahydrofolate metabolic process	GO:0046653	8.62	DHFR TYMS

Molecular functions related to Plasmodium Malariae Malaria according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA binding	GO:0003729	9.32	DHFR TYMS
2	translation repressor activity, mRNA regulatory element binding	GO:0000900	9.26	DHFR TYMS
3	folic acid binding	GO:0005542	9.16	DHFR TYMS
4	sequence-specific mRNA binding	GO:1990825	8.96	DHFR TYMS
5	drug binding	GO:0008144	8.8	ALB DHFR TYMS

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