MCID: PLT016
MIFTS: 17

Platelet Adenylate Cyclase Activity

Categories: Blood diseases

Aliases & Classifications for Platelet Adenylate Cyclase Activity

MalaCards integrated aliases for Platelet Adenylate Cyclase Activity:

Name: Platelet Adenylate Cyclase Activity 57 55

Classifications:



External Ids:

OMIM 57 173395

Summaries for Platelet Adenylate Cyclase Activity

MalaCards based summary : Platelet Adenylate Cyclase Activity is related to withdrawal disorder and pertussis. An important gene associated with Platelet Adenylate Cyclase Activity is ADCY10 (Adenylate Cyclase 10), and among its related pathways/superpathways are Sweet Taste Signaling and cAMP signaling pathway. Related phenotype is Decreased shRNA abundance.

More information from OMIM: 173395

Related Diseases for Platelet Adenylate Cyclase Activity

Diseases related to Platelet Adenylate Cyclase Activity via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 withdrawal disorder 10.1
2 pertussis 10.1
3 cholera 10.1
4 hyperinsulinism 10.1
5 post-traumatic stress disorder 10.1
6 acute stress disorder 10.1
7 pulmonary embolism 10.1

Graphical network of the top 20 diseases related to Platelet Adenylate Cyclase Activity:



Diseases related to Platelet Adenylate Cyclase Activity

Symptoms & Phenotypes for Platelet Adenylate Cyclase Activity

Clinical features from OMIM:

173395

GenomeRNAi Phenotypes related to Platelet Adenylate Cyclase Activity according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00297-A 8.62 ADCY10 PDE4A

Drugs & Therapeutics for Platelet Adenylate Cyclase Activity

Search Clinical Trials , NIH Clinical Center for Platelet Adenylate Cyclase Activity

Genetic Tests for Platelet Adenylate Cyclase Activity

Anatomical Context for Platelet Adenylate Cyclase Activity

Publications for Platelet Adenylate Cyclase Activity

Articles related to Platelet Adenylate Cyclase Activity:

(show all 42)
# Title Authors PMID Year
1
A genetic study of platelet adenylate cyclase activity: evidence for a single major locus effect in fluoride-stimulated activity. 38 8
1867196 1991
2
Differences in platelet enzyme activity between alcoholics and nonalcoholics. 38 8
3336400 1988
3
Octimibate inhibition of platelet aggregation: stimulation of adenylate cyclase through prostacyclin receptor activation. 9 38
2175792 1990
4
Exaggerated platelet reactivity to physiological agonists in war veterans with posttraumatic stress disorder. 38
20863624 2011
5
Biological markers of alcohol consumption in nondrinkers, drinkers, and alcohol-dependent Brazilian patients. 38
12170116 2002
6
Inhibition of human platelet adenylate cyclase activity by adrenaline, thrombin and collagen: analysis and reinterpretation of experimental data. 38
10391837 1999
7
Genetic markers of alcohol abuse. 38
9118563 1997
8
Absence of reduced platelet adenylate cyclase activity in Vietnam veterans with PTSD. 38
7727631 1995
9
Platelet adenylate cyclase activity in Israeli victims of Iraqi Scud missile attacks with post-traumatic stress disorder. 38
7855210 1994
10
2-[3-[2-(4,5-Diphenyl-2-oxazolyl) ethyl] phenoxy] acetic acid (BMY 42393): a new, structurally-novel prostacyclin partial agonist: 1). Inhibition of platelet aggregation and mechanism of action. 38
8029812 1994
11
The effects of in vitro and in vivo exposure to insulin upon prostaglandin E1 stimulation of platelet adenylate cyclase activity in healthy subjects. 38
7648795 1994
12
Platelet adenylate cyclase and monoamine oxidase in women with alcoholism or a family history of alcoholism. 38
9384852 1993
13
[Platelet adenylate cyclase activity in alcoholics]. 38
1492798 1992
14
[Acyl and plasmalogen analogs of platelet activating factor--new lipid cellular bioregulators]. 38
1420585 1992
15
Inhibition of platelet aggregation by prostacyclin is attenuated after exercise in patients with angina pectoris. 38
1736562 1992
16
Involvement of the "tethered-ligand" receptor in thrombin inhibition of platelet adenylate cyclase. 38
1371679 1992
17
Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function. 38
1365662 1992
18
Decrease in epinephrine-induced attenuation of platelet adenylate cyclase activity in depressed patients: relation with plasma electrolytes. 38
1338221 1992
19
Species differences in alpha 2-adrenergic regulation of platelet adenylate cyclase. 38
1658886 1991
20
The local anaesthetic benzyl alcohol attenuates the alpha 2-adrenoceptor-mediated inhibition of human platelet adenylate cyclase activity when stimulated by prostaglandin E1, but not that stimulated by forskolin. 38
2557841 1989
21
[Thrombocyte function in unstable angina pectoris]. 38
2840254 1988
22
Vasopressin inhibition of human platelet adenylate cyclase: variable responsiveness between donors and involvement of a G-protein different from Gi. 38
3138140 1988
23
Lithium modulation of second messenger signal amplification in man: inhibition of phosphatidylinositol-specific phospholipase C and adenylate cyclase activity. 38
2839860 1988
24
Isolation and characterization of 9-hydroxy-10-trans,12-cis-octadecadienoic acid, a novel regulator of platelet adenylate cyclase from Glechoma hederacea L. Labiatae. 38
3691528 1987
25
[Platelet adenylate cyclase activity in alcoholics]. 38
3449035 1987
26
Effect of lithium in vitro and after chronic treatment on human platelet adenylate cyclase activity: postreceptor modification of second messenger signal amplification. 38
2819913 1987
27
Plasmin: a possible physiological modulator of the human platelet adenylate cyclase system. 38
2951052 1987
28
[Effect of a physical load on the adrenergic receptor function of peripheral blood lymphocytes and thrombocytes in healthy donors]. 38
3038142 1987
29
Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase activity in heroin addicts in abstinence. 38
2819917 1987
30
Purification of a beta 35 form of the beta gamma complex common to G-proteins from human placental membranes. 38
2432057 1987
31
Effects of heparin on prostacyclin binding and platelet adenylate cyclase activity stimulated by iloprost and forskolin. 38
2432618 1986
32
Age related decline in aluminum-activated human platelet adenylate cyclase: post-receptor changes in cyclic AMP second messenger signal amplification in normal aging and dementia of the Alzheimer type. 38
3747724 1986
33
Effects of enprofylline on A1 and A2 adenosine receptors. 38
3002801 1985
34
Enhanced signal transduction by adenylate cyclase in platelet membranes of patients showing antidepressant responses to alprazolam: preliminary data. 38
2985777 1985
35
Inhibitory effect of ristocetin and factor VIII/von Willebrand factor protein on human platelet adenylate cyclase activity. 38
6408756 1983
36
The adrenergic responsiveness of Down syndrome cells. 38
6296879 1982
37
Inhibitory effects of sodium and other monovalent cations on human platelet adenylate cyclase. 38
7196915 1981
38
Increased platelet adenylate cyclase activity ion diabetic patients with microangiography. 38
6172351 1981
39
Influence of metabolic control on platelet functions in diabetic mellitus. 38
6274778 1981
40
Effect of acute methadone withdrawal on prostaglandin E-stimulated 3H-cyclic adenosine monophosphate accumulation in human platelets. 38
6245830 1980
41
Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties. 38
218223 1979
42
Effect of chilling on platelet cyclic adenosine 3:5-monophosphate and adenylate cyclase activity. 38
176753 1976

Variations for Platelet Adenylate Cyclase Activity

Expression for Platelet Adenylate Cyclase Activity

Search GEO for disease gene expression data for Platelet Adenylate Cyclase Activity.

Pathways for Platelet Adenylate Cyclase Activity

Pathways related to Platelet Adenylate Cyclase Activity according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.84 PDE4A ADCY10
2 10.95 PDE4A ADCY10

GO Terms for Platelet Adenylate Cyclase Activity

Cellular components related to Platelet Adenylate Cyclase Activity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 8.96 PDE4A ADCY10
2 perinuclear region of cytoplasm GO:0048471 8.62 PDE4A ADCY10

Sources for Platelet Adenylate Cyclase Activity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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