MCID: PLT016
MIFTS: 15

Platelet Adenylate Cyclase Activity

Categories: Blood diseases

Aliases & Classifications for Platelet Adenylate Cyclase Activity

MalaCards integrated aliases for Platelet Adenylate Cyclase Activity:

Name: Platelet Adenylate Cyclase Activity 57 55

Classifications:



External Ids:

OMIM 57 173395

Summaries for Platelet Adenylate Cyclase Activity

MalaCards based summary : Platelet Adenylate Cyclase Activity is related to depression and post-traumatic stress disorder. An important gene associated with Platelet Adenylate Cyclase Activity is ADCY10 (Adenylate Cyclase 10), and among its related pathways/superpathways are Sweet Taste Signaling and Purine metabolism (KEGG). Related phenotype is Decreased shRNA abundance.

Description from OMIM: 173395

Related Diseases for Platelet Adenylate Cyclase Activity

Diseases related to Platelet Adenylate Cyclase Activity via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 depression 10.1
2 post-traumatic stress disorder 9.9

Symptoms & Phenotypes for Platelet Adenylate Cyclase Activity

Clinical features from OMIM:

173395

GenomeRNAi Phenotypes related to Platelet Adenylate Cyclase Activity according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00297-A 8.62 ADCY10 PDE4A

Drugs & Therapeutics for Platelet Adenylate Cyclase Activity

Search Clinical Trials , NIH Clinical Center for Platelet Adenylate Cyclase Activity

Genetic Tests for Platelet Adenylate Cyclase Activity

Anatomical Context for Platelet Adenylate Cyclase Activity

Publications for Platelet Adenylate Cyclase Activity

Articles related to Platelet Adenylate Cyclase Activity:

(show all 13)
# Title Authors Year
1
Inhibition of human platelet adenylate cyclase activity by adrenaline, thrombin and collagen: analysis and reinterpretation of experimental data. ( 10391837 )
1999
2
Absence of reduced platelet adenylate cyclase activity in Vietnam veterans with PTSD. ( 7727631 )
1995
3
Platelet adenylate cyclase activity in Israeli victims of Iraqi Scud missile attacks with post-traumatic stress disorder. ( 7855210 )
1994
4
The effects of in vitro and in vivo exposure to insulin upon prostaglandin E1 stimulation of platelet adenylate cyclase activity in healthy subjects. ( 7648795 )
1994
5
Decrease in epinephrine-induced attenuation of platelet adenylate cyclase activity in depressed patients: relation with plasma electrolytes. ( 1338221 )
1992
6
Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function. ( 1365662 )
1992
7
A genetic study of platelet adenylate cyclase activity: evidence for a single major locus effect in fluoride-stimulated activity. ( 1867196 )
1991
8
The local anaesthetic benzyl alcohol attenuates the alpha 2-adrenoceptor-mediated inhibition of human platelet adenylate cyclase activity when stimulated by prostaglandin E1, but not that stimulated by forskolin. ( 2557841 )
1989
9
Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase activity in heroin addicts in abstinence. ( 2819917 )
1987
10
Effect of lithium in vitro and after chronic treatment on human platelet adenylate cyclase activity: postreceptor modification of second messenger signal amplification. ( 2819913 )
1987
11
Effects of heparin on prostacyclin binding and platelet adenylate cyclase activity stimulated by iloprost and forskolin. ( 2432618 )
1986
12
Inhibitory effect of ristocetin and factor VIII/von Willebrand factor protein on human platelet adenylate cyclase activity. ( 6408756 )
1983
13
Increased platelet adenylate cyclase activity ion diabetic patients with microangiography. ( 6172351 )
1981

Variations for Platelet Adenylate Cyclase Activity

Expression for Platelet Adenylate Cyclase Activity

Search GEO for disease gene expression data for Platelet Adenylate Cyclase Activity.

Pathways for Platelet Adenylate Cyclase Activity

Pathways related to Platelet Adenylate Cyclase Activity according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 ADCY10 PDE4A
2
Show member pathways
11.52 ADCY10 PDE4A
3
Show member pathways
10.93 ADCY10 PDE4A

GO Terms for Platelet Adenylate Cyclase Activity

Cellular components related to Platelet Adenylate Cyclase Activity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 8.96 ADCY10 PDE4A
2 perinuclear region of cytoplasm GO:0048471 8.62 ADCY10 PDE4A

Sources for Platelet Adenylate Cyclase Activity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....