MCID: PLT015
MIFTS: 42

Platelet Aggregation, Spontaneous

Categories: Blood diseases

Aliases & Classifications for Platelet Aggregation, Spontaneous

MalaCards integrated aliases for Platelet Aggregation, Spontaneous:

Name: Platelet Aggregation, Spontaneous 58 56 74
Spontaneous Platelet Aggregation 30

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
platelet aggregation, spontaneous:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 173400
MedGen 43 C1868263
SNOMED-CT via HPO 70 263681008
UMLS 74 C1868263

Summaries for Platelet Aggregation, Spontaneous

MalaCards based summary : Platelet Aggregation, Spontaneous, also known as spontaneous platelet aggregation, is related to von willebrand's disease and cerebrovascular disease. An important gene associated with Platelet Aggregation, Spontaneous is CANT1 (Calcium Activated Nucleotidase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include whole blood and testes, and related phenotypes are recurrent thrombophlebitis and spontaneous platelet aggregation

Description from OMIM: 173400

Related Diseases for Platelet Aggregation, Spontaneous

Diseases related to Platelet Aggregation, Spontaneous via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 von willebrand's disease 30.4 SELP VWF
2 cerebrovascular disease 30.0 PLAT SELP VWF
3 ischemia 29.4 PLAT SELP SOD1
4 hypertension, essential 29.2 PF4 PLAT SELP VWF
5 acute myocardial infarction 29.1 PLAT SELP SERPINC1 SERPINF2 VWF
6 myocardial infarction 28.8 PF4 PLAT SELP SERPINC1 SERPINF2 VWF
7 qualitative platelet defect 10.3 SELP VWF
8 primary thrombocytopenia 10.2 SELP VWF
9 autoimmune disease of blood 10.2 SELP VWF
10 anomalous left coronary artery from the pulmonary artery 10.2 PF4 VWF
11 purpura 10.2 SERPINC1 VWF
12 intestinal impaction 10.2 SERPINC1 SERPINF2
13 alpha-2-plasmin inhibitor deficiency 10.2 SERPINC1 SERPINF2
14 giant hemangioma 10.2 SERPINC1 SERPINF2
15 retinal vascular occlusion 10.2 SELP SERPINC1
16 inherited blood coagulation disease 10.2 SERPINC1 VWF
17 intracranial thrombosis 10.1 SERPINC1 VWF
18 livedoid vasculitis 10.1 SERPINC1 SERPINF2
19 purpura fulminans 10.1 SERPINC1 SERPINF2
20 hepatic vascular disease 10.1 SERPINC1 VWF
21 legg-calve-perthes disease 10.1 SELP SERPINC1
22 thrombotic thrombocytopenic purpura 10.1 SELP VWF
23 plasminogen activator inhibitor-1 deficiency 10.1 PLAT SERPINF2
24 portal vein thrombosis 10.1 SELP SERPINC1
25 carotid artery thrombosis 10.1 PLAT SELP
26 eisenmenger syndrome 10.1 PLAT VWF
27 leech infestation 10.1 PF4 SERPINC1
28 acute cor pulmonale 10.1 PLAT SERPINF2
29 acute pulmonary heart disease 10.1 PLAT SERPINF2
30 gray platelet syndrome 10.1 SELP VWF
31 endocarditis 10.1 PLAT SERPINC1
32 pregnancy adenoma 10.1 PLAT SERPINF2
33 rubeosis iridis 10.1 PF4 SERPINF2
34 factor x deficiency 10.0 SERPINC1 VWF
35 fibrinolytic defect 10.0 PLAT SERPINC1
36 argentine hemorrhagic fever 10.0 PLAT SERPINC1
37 posterior myocardial infarction 10.0 PLAT SERPINC1
38 chronic venous insufficiency 10.0 PLAT SELP
39 encephalopathy, familial, with neuroserpin inclusion bodies 10.0 PLAT SERPINC1
40 alpha-1-antitrypsin deficiency 10.0 SERPINA3 SERPINC1
41 pleuropneumonia 10.0 PLAT SERPINC1
42 intermittent claudication 10.0 SELP SERPINC1 VWF
43 korean hemorrhagic fever 10.0 SERPINC1 SERPINF2 VWF
44 bone marrow cancer 10.0 PF4 SELP VWF
45 essential thrombocythemia 10.0 PF4 SELP VWF
46 diabetes mellitus 10.0
47 thrombocytopenia 10.0
48 pulmonary artery disease 10.0 PLAT SERPINC1
49 dysfibrinogenemia 9.9 PLAT SERPINC1
50 grange syndrome 9.9 PLAT SELP VWF

Graphical network of the top 20 diseases related to Platelet Aggregation, Spontaneous:



Diseases related to Platelet Aggregation, Spontaneous

Symptoms & Phenotypes for Platelet Aggregation, Spontaneous

Human phenotypes related to Platelet Aggregation, Spontaneous:

33
# Description HPO Frequency HPO Source Accession
1 recurrent thrombophlebitis 33 HP:0004419
2 spontaneous platelet aggregation 33 HP:0030403

Symptoms via clinical synopsis from OMIM:

58
Vascular:
recurrent phlebitis

Lab:
spontaneous platelet aggregation

Clinical features from OMIM:

173400

MGI Mouse Phenotypes related to Platelet Aggregation, Spontaneous:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 CANT1 PLAT SELP SERPINC1 SOD1 VWF
2 hematopoietic system MP:0005397 9.63 PF4 PLAT SELP SERPINC1 SOD1 VWF
3 homeostasis/metabolism MP:0005376 9.5 PF4 PLAT SELP SERPINC1 SERPINF2 SOD1
4 vision/eye MP:0005391 9.02 CANT1 PLAT SELP SERPINC1 SOD1

Drugs & Therapeutics for Platelet Aggregation, Spontaneous

Drugs for Platelet Aggregation, Spontaneous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 2,Not Applicable 50-78-2 2244
2
Clopidogrel Approved Phase 2 120202-66-6, 113665-84-2 60606
3
arachidonic acid Experimental Phase 2 506-32-1 444899
4 Analgesics Phase 2,Not Applicable
5 Purinergic P2 Receptor Antagonists Phase 2
6 Peripheral Nervous System Agents Phase 2,Not Applicable
7 Cyclooxygenase Inhibitors Phase 2,Not Applicable
8 Antipyretics Phase 2,Not Applicable
9 Analgesics, Non-Narcotic Phase 2,Not Applicable
10 Antirheumatic Agents Phase 2,Not Applicable
11 Neurotransmitter Agents Phase 2
12 Anti-Inflammatory Agents Phase 2,Not Applicable
13 Anti-Inflammatory Agents, Non-Steroidal Phase 2,Not Applicable
14 Fibrinolytic Agents Phase 2,Not Applicable
15 Platelet Aggregation Inhibitors Phase 2,Not Applicable
16 Purinergic P2Y Receptor Antagonists Phase 2
17
Tocopherol Approved, Investigational Not Applicable 1406-66-2 14986
18
Abacavir Approved, Investigational 136470-78-5 441300 65140
19
Vitamin E Approved, Nutraceutical, Vet_approved Not Applicable 59-02-9 14985
20 Tocotrienol Investigational Not Applicable 6829-55-6
21
Tenofovir Experimental, Investigational 147127-20-6 464205
22 Micronutrients Not Applicable
23 Antioxidants Not Applicable
24 Tocotrienols Not Applicable
25 Trace Elements Not Applicable
26 Protective Agents Not Applicable
27 Vitamins Not Applicable
28 Tocopherols Not Applicable
29 Nutrients Not Applicable
30 Reverse Transcriptase Inhibitors
31 Anti-HIV Agents
32 Anti-Infective Agents
33 Anti-Retroviral Agents
34 Antiviral Agents
35 Nucleic Acid Synthesis Inhibitors
36
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Targeting Platelets in Chronic HIV Infection Completed NCT02578706 Phase 2 Clopidogrel;Aspirin;Placebo
2 Effects of Tocotrienols Supplementation on Platelet Aggregation in Subjects With Metabolic Syndrome Completed NCT01631838 Not Applicable
3 Effects of Fish Oil on Platelet Function and Coagulation Completed NCT03048981 Not Applicable Fish oil
4 Migraine Relief After Patent Foramen Ovale Closure: a Single Center Analysis Recruiting NCT03521193 Not Applicable
5 Platelet Function on Abacavir and Tenofovir Recruiting NCT03081572
6 Platelet Antisedimentation Rate and Multiplate Exams in Patients on Antiplatelet Therapy and Controls Recruiting NCT03679858
7 Laboratory Implications of Non Obstructive Atherosclerotic Plaques Identified by Multiple Detector Coronary Angiotomography Enrolling by invitation NCT03632785

Search NIH Clinical Center for Platelet Aggregation, Spontaneous

Genetic Tests for Platelet Aggregation, Spontaneous

Genetic tests related to Platelet Aggregation, Spontaneous:

# Genetic test Affiliating Genes
1 Spontaneous Platelet Aggregation 30

Anatomical Context for Platelet Aggregation, Spontaneous

MalaCards organs/tissues related to Platelet Aggregation, Spontaneous:

42
Whole Blood, Testes

Publications for Platelet Aggregation, Spontaneous

Articles related to Platelet Aggregation, Spontaneous:

(show top 50) (show all 76)
# Title Authors Year
1
Reduced spontaneous platelet aggregation: a novel risk factor for adverse pregnancy outcome. ( 26927895 )
2016
2
Assessment of spontaneous platelet aggregation using laser light scattering in healthy subjects: an attempt to standardize. ( 24661348 )
2014
3
Spontaneous platelet aggregation in patients with acute coronary syndrome. ( 23667880 )
2013
4
Spontaneous platelet aggregation evaluated by laser light scatter in patients with type 2 diabetes: effects of short-term improved glycemic control and adiponectin. ( 22153806 )
2012
5
Why and how to eliminate spontaneous platelet aggregation in blood measured by multiple electrode aggregometry. ( 22712617 )
2012
6
[Effect of fibrin monomer on spontaneous platelet aggregation]. ( 21584967 )
2011
7
Soluble but not platelet P-selectin correlates with spontaneous platelet aggregation: a pilot study. ( 18252728 )
2008
8
Spontaneous platelet aggregation in normal subject assessed by a laser light scattering method: an attempt at standardization. ( 18569865 )
2008
9
Participation of IIb-IIIa glycoprotein in spontaneous platelet aggregation. ( 18214290 )
2007
10
Comparison of the effects of unfractionated heparin and the low-molecular-weight heparins dalteparin and enoxaparin on spontaneous platelet aggregation and adenosine diphosphate activity in platelets during the third trimester of pregnancy. ( 18040530 )
2007
11
Comparative study of vasaprostan and alprostan in spontaneous platelet aggregation test in mice. ( 15665962 )
2004
12
Spontaneous platelet aggregation in Kawasaki disease using the particle counting method. ( 14651534 )
2003
13
A new method to evaluate spontaneous platelet aggregation in type 2 diabetes by Cellfacts. ( 12589971 )
2003
14
Spontaneous platelet aggregation in patients with Behçet's disease by using laser-light scattering aggregometer. ( 12918740 )
2003
15
Influence of spontaneous platelet aggregation on progression of glomerular disease. ( 12187082 )
2002
16
Spontaneous platelet aggregation with congenital giant platelet containing large granules and thick membrane. ( 11697714 )
2001
17
Inhibition of induced and spontaneous platelet aggregation by destabilase from medicinal leech. ( 10938885 )
2000
18
Spontaneous platelet aggregation as a predictive risk factor for vascular occlusions in healthy volunteers? Results of the HAPARG Study. Haemostatic parameters as risk factors in healthy volunteers. ( 10381294 )
1999
19
Cutaneous vascular infarcts secondary to spontaneous platelet aggregation. ( 9747375 )
1998
20
A cross-sectional evaluation of spontaneous platelet aggregation in relation to complications in patients with type II diabetes mellitus. ( 9627370 )
1998
21
A low molecular weight heparin, nadroparin (Fraxiparine), inhibits thrombin-induced platelet shape change and does not enhance spontaneous platelet aggregation. ( 8838445 )
1996
22
Spontaneous platelet aggregation in whole blood is increased in non-insulin-dependent diabetes mellitus and in female but not male patients with primary dyslipidemia. ( 7772062 )
1995
23
Factors that contribute to spontaneous platelet aggregation and streptokinase-induced aggregation in whole blood. ( 7540774 )
1995
24
Anticoagulation for heparin-induced thrombocytopenia with spontaneous platelet aggregation in a patient requiring haemodialysis. ( 8643186 )
1995
25
Evaluation of platelet hyperfunction in aged subjects using spontaneous platelet aggregation in whole blood. ( 15374203 )
1995
26
"Spontaneous" platelet aggregation in whole blood in diabetic and non diabetic survivors of acute myocardial infarction. ( 8165614 )
1993
27
Standard heparin and low molecular weight heparin effect on spontaneous platelet aggregation measured in whole blood and in platelet-rich plasma. ( 8249540 )
1993
28
Heparin infusion facilitates ex vivo spontaneous platelet aggregation in patients with acute myocardial infarction who have undergone thrombolytic therapy. ( 8314168 )
1993
29
Increase in spontaneous platelet aggregation in beta-thalassemia/hemoglobin E disease: a consequence of splenectomy. ( 1298991 )
1992
30
Spontaneous platelet aggregation in thalassemic children and adolescents. ( 1298992 )
1992
31
Assessment of whole-blood spontaneous platelet aggregation during pregnancy using an impedance particle counter. ( 1427461 )
1992
32
Spontaneous platelet aggregation, tourniquet ischaemia, and aspirin in survivors of myocardial infarction. ( 21043899 )
1992
33
Erythropoietin and spontaneous platelet aggregation in haemodialysis patients. ( 1682739 )
1991
34
[Measurement of spontaneous platelet aggregation in citrated whole blood by application of the hematologic automatic Coulter S plus VI]. ( 2068852 )
1991
35
Diltiazem inhibits the spontaneous platelet aggregation in essential hypertension. ( 1834333 )
1991
36
Enhanced Spontaneous Platelet Aggregation and red Blood Cell Fragility in Whole Blood Obtained from Patients with Diabetes. ( 21043929 )
1991
37
Glucose increases spontaneous platelet aggregation in whole blood. ( 2122545 )
1990
38
Spontaneous platelet aggregation during pregnancy in a patient with von Willebrand disease type IIB can be blocked by monoclonal antibodies to both platelet glycoproteins Ib and IIb/IIIa. ( 2375928 )
1990
39
Inhibitory effect of vitamin E (alpha-tocopherol) on spontaneous platelet aggregation in whole blood. ( 2082481 )
1990
40
Is spontaneous platelet aggregation present in whole blood in vitro? ( 2274924 )
1990
41
[Spontaneous platelet aggregation after experimental focal ischemia in the rabbit. "Sensitivity", "specificity" and value of the test used]. ( 2915816 )
1989
42
Different platelet binding sites are probably involved in spontaneous platelet aggregation induced by IIB von Willebrand factor in normals and in IIB von Willebrand's disease patients. ( 2803970 )
1989
43
Spontaneous platelet aggregation in type IIB Tampa von Willebrand disease is inhibited by the 52/48-kDa fragment of normal von Willebrand factor, which contains the GPIb binding domain. ( 2783833 )
1989
44
A new congenital platelet abnormality characterized by spontaneous platelet aggregation, enhanced von Willebrand factor platelet interaction, and the presence of all von Willebrand factor multimers in plasma. ( 2804346 )
1989
45
In vivo antiaggregatory effect of BM 13.177 on the spontaneous platelet aggregation in anaesthetized beagle dogs. ( 3073773 )
1988
46
Effects of PGI2, CH-7284 and CH-7384 on spontaneous platelet aggregation and blood pressure of anaesthetized beagles. ( 3073758 )
1988
47
Spontaneous platelet aggregation: observations on potential mechanisms. ( 3660339 )
1987
48
Effect of dipyridamole on spontaneous platelet aggregation in whole blood decreases with the time after venepuncture: evidence for the role of ADP. ( 3672426 )
1987
49
Spontaneous platelet aggregation and coagulation parameters as risk factors for arterial occlusions in diabetics. Results of the PARD-study. ( 3104511 )
1986
50
Spontaneous platelet aggregation in heparinised blood during pregnancy. ( 3705014 )
1986

Variations for Platelet Aggregation, Spontaneous

Expression for Platelet Aggregation, Spontaneous

Search GEO for disease gene expression data for Platelet Aggregation, Spontaneous.

Pathways for Platelet Aggregation, Spontaneous

GO Terms for Platelet Aggregation, Spontaneous

Cellular components related to Platelet Aggregation, Spontaneous according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.87 CANT1 PLAT SERPINA3 SERPINC1 SERPINF2 SOD1
2 extracellular space GO:0005615 9.8 PF4 PLAT SELP SERPINA3 SERPINC1 SERPINF2
3 extracellular region GO:0005576 9.76 CANT1 PF4 PLAT SERPINA3 SERPINC1 SERPINF2
4 blood microparticle GO:0072562 9.54 SERPINA3 SERPINC1 SERPINF2
5 platelet alpha granule lumen GO:0031093 9.26 PF4 SERPINA3 SERPINF2 VWF
6 collagen-containing extracellular matrix GO:0062023 9.1 PF4 PLAT SERPINA3 SERPINC1 SERPINF2 VWF

Biological processes related to Platelet Aggregation, Spontaneous according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.61 PF4 SELP SERPINA3
2 blood coagulation GO:0007596 9.5 PLAT SERPINC1 VWF
3 hemostasis GO:0007599 9.4 SERPINC1 VWF
4 acute-phase response GO:0006953 9.37 SERPINA3 SERPINF2
5 negative regulation of endopeptidase activity GO:0010951 9.33 SERPINA3 SERPINC1 SERPINF2
6 fibrinolysis GO:0042730 9.26 PLAT SERPINF2
7 negative regulation of peptidase activity GO:0010466 9.13 SERPINA3 SERPINC1 SERPINF2
8 platelet degranulation GO:0002576 9.1 PF4 SELP SERPINA3 SERPINF2 SOD1 VWF

Molecular functions related to Platelet Aggregation, Spontaneous according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.62 CANT1 SERPINF2 SOD1 VWF
2 heparin binding GO:0008201 9.43 PF4 SELP SERPINC1
3 peptidase inhibitor activity GO:0030414 9.33 SERPINA3 SERPINC1 SERPINF2
4 protease binding GO:0002020 9.13 SERPINC1 SERPINF2 VWF
5 serine-type endopeptidase inhibitor activity GO:0004867 8.8 SERPINA3 SERPINC1 SERPINF2

Sources for Platelet Aggregation, Spontaneous

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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