MCID: PLT015
MIFTS: 40

Platelet Aggregation, Spontaneous

Categories: Blood diseases

Aliases & Classifications for Platelet Aggregation, Spontaneous

MalaCards integrated aliases for Platelet Aggregation, Spontaneous:

Name: Platelet Aggregation, Spontaneous 57 55 73
Spontaneous Platelet Aggregation 29

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
platelet aggregation, spontaneous:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 173400
MedGen 42 C1868263
SNOMED-CT via HPO 69 263681008
UMLS 73 C1868263

Summaries for Platelet Aggregation, Spontaneous

MalaCards based summary : Platelet Aggregation, Spontaneous, also known as spontaneous platelet aggregation, is related to von willebrand's disease and ischemia. An important gene associated with Platelet Aggregation, Spontaneous is CANT1 (Calcium Activated Nucleotidase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include whole blood and testes, and related phenotypes are recurrent thrombophlebitis and spontaneous platelet aggregation

Description from OMIM: 173400

Related Diseases for Platelet Aggregation, Spontaneous

Diseases related to Platelet Aggregation, Spontaneous via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 von willebrand's disease 30.3 SELP VWF
2 ischemia 28.4 PLAT SELP SOD1
3 qualitative platelet defect 10.6 SELP VWF
4 primary thrombocytopenia 10.5 SELP VWF
5 heparin-induced thrombocytopenia 10.4 SELP SERPINC1
6 anomalous left coronary artery from the pulmonary artery 10.4 PF4 VWF
7 inherited blood coagulation disease 10.4 SERPINC1 VWF
8 intestinal impaction 10.4 SERPINC1 SERPINF2
9 gray platelet syndrome 10.3 SELP VWF
10 intracranial thrombosis 10.3 SERPINC1 VWF
11 alpha-2-plasmin inhibitor deficiency 10.3 SERPINC1 SERPINF2
12 thrombotic thrombocytopenic purpura 10.3 SELP VWF
13 giant hemangioma 10.3 SERPINC1 SERPINF2
14 retinal vascular occlusion 10.3 SELP SERPINC1
15 factor xii deficiency 10.3 SERPINC1 VWF
16 purpura fulminans 10.3 SERPINC1 SERPINF2
17 legg-calve-perthes disease 10.3 SELP SERPINC1
18 eisenmenger syndrome 10.3 PLAT VWF
19 portal vein thrombosis 10.2 SELP SERPINC1
20 plasminogen activator inhibitor-1 deficiency 10.2 PLAT SERPINF2
21 carotid artery thrombosis 10.2 PLAT SELP
22 rubeosis iridis 10.2 PF4 SERPINF2
23 acute cor pulmonale 10.1 PLAT SERPINF2
24 acute pulmonary heart disease 10.1 PLAT SERPINF2
25 factor x deficiency 10.1 SERPINC1 VWF
26 fibrinolytic defect 10.1 PLAT SERPINC1
27 chronic venous insufficiency 10.1 PLAT SELP
28 argentine hemorrhagic fever 10.1 PLAT SERPINC1
29 coronary restenosis 10.1 PLAT SERPINC1
30 alpha-1-antitrypsin deficiency 10.1 SERPINA3 SERPINC1
31 posterior myocardial infarction 10.1 PLAT SERPINC1
32 encephalopathy, familial, with neuroserpin inclusion bodies 10.0 PLAT SERPINC1
33 intermittent claudication 10.0 SELP SERPINC1 VWF
34 thrombocytosis 10.0 SELP SERPINC1
35 angina pectoris 10.0 SERPINC1 SERPINF2 VWF
36 korean hemorrhagic fever 10.0 SERPINC1 SERPINF2 VWF
37 bone marrow cancer 10.0 PF4 SELP VWF
38 glanzmann thrombasthenia 10.0 SELP VWF
39 essential thrombocythemia 10.0 PF4 SELP VWF
40 dysfibrinogenemia 9.9 PLAT SERPINC1
41 varicose veins 9.9 SERPINC1 VWF
42 hepatic veno-occlusive disease 9.9 PLAT SERPINC1
43 venous insufficiency 9.9 PLAT SELP VWF
44 vein disease 9.9 PLAT SERPINC1
45 cerebrovascular disease 9.9 PLAT SELP VWF
46 mitral valve stenosis 9.8 PF4 SELP SERPINC1
47 immune system disease 9.8 PF4 SERPINC1 VWF
48 cold urticaria 9.8 PF4 SERPINC1 SERPINF2
49 myocardial stunning 9.7 SERPINC1 SOD1
50 coronary thrombosis 9.7 PLAT SERPINC1 VWF

Graphical network of the top 20 diseases related to Platelet Aggregation, Spontaneous:



Diseases related to Platelet Aggregation, Spontaneous

Symptoms & Phenotypes for Platelet Aggregation, Spontaneous

Symptoms via clinical synopsis from OMIM:

57
Vascular:
recurrent phlebitis

Lab:
spontaneous platelet aggregation


Clinical features from OMIM:

173400

Human phenotypes related to Platelet Aggregation, Spontaneous:

32
# Description HPO Frequency HPO Source Accession
1 recurrent thrombophlebitis 32 HP:0004419
2 spontaneous platelet aggregation 32 HP:0030403

MGI Mouse Phenotypes related to Platelet Aggregation, Spontaneous:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 CANT1 PLAT SELP SERPINC1 SOD1 VWF
2 homeostasis/metabolism MP:0005376 9.5 SOD1 VWF PF4 PLAT SELP SERPINC1
3 vision/eye MP:0005391 9.02 CANT1 PLAT SELP SERPINC1 SOD1

Drugs & Therapeutics for Platelet Aggregation, Spontaneous

Drugs for Platelet Aggregation, Spontaneous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
2
Clopidogrel Approved Phase 2 120202-66-6, 113665-84-2 60606
3
Ticlopidine Approved Phase 2 55142-85-3 5472
4 Analgesics Phase 2
5 Analgesics, Non-Narcotic Phase 2
6 Anti-Inflammatory Agents Phase 2
7 Anti-Inflammatory Agents, Non-Steroidal Phase 2
8 Antipyretics Phase 2
9 Antirheumatic Agents Phase 2
10 Cyclooxygenase Inhibitors Phase 2
11 Cytochrome P-450 Enzyme Inhibitors Phase 2
12 Fibrinolytic Agents Phase 2
13 Neurotransmitter Agents Phase 2
14 Peripheral Nervous System Agents Phase 2
15 Platelet Aggregation Inhibitors Phase 2
16 Purinergic P2 Receptor Antagonists Phase 2
17 Purinergic P2Y Receptor Antagonists Phase 2
18
arachidonic acid Experimental, Nutraceutical Phase 2 506-32-1 444899
19
Abacavir Approved, Investigational 136470-78-5 65140 441300
20
Tocopherol Approved, Investigational, Nutraceutical Not Applicable 1406-66-2 14986
21
Vitamin E Approved, Nutraceutical, Vet_approved Not Applicable 59-02-9 14985
22 Antioxidants Not Applicable
23 Micronutrients Not Applicable
24 Protective Agents Not Applicable
25 Tocopherols Not Applicable
26 Tocotrienols Not Applicable
27 Trace Elements Not Applicable
28 Vitamins Not Applicable
29 Anti-HIV Agents
30 Anti-Infective Agents
31 Anti-Retroviral Agents
32 Antiviral Agents
33 Nucleic Acid Synthesis Inhibitors
34 Reverse Transcriptase Inhibitors
35
Tenofovir 147127-20-6 464205
36 Tocotrienol Investigational, Nutraceutical Not Applicable 6829-55-6

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Targeting Platelets in Chronic HIV Infection Completed NCT02578706 Phase 2 Clopidogrel;Aspirin;Placebo
2 Effects of Tocotrienols Supplementation on Platelet Aggregation in Subjects With Metabolic Syndrome Completed NCT01631838 Not Applicable
3 Effects of Fish Oil on Platelet Function and Coagulation Completed NCT03048981 Not Applicable Fish oil
4 Migraine Relief After Patent Foramen Ovale Closure: a Single Center Analysis Recruiting NCT03521193 Not Applicable
5 Platelet Function on Abacavir and Tenofovir Recruiting NCT03081572

Search NIH Clinical Center for Platelet Aggregation, Spontaneous

Genetic Tests for Platelet Aggregation, Spontaneous

Genetic tests related to Platelet Aggregation, Spontaneous:

# Genetic test Affiliating Genes
1 Spontaneous Platelet Aggregation 29

Anatomical Context for Platelet Aggregation, Spontaneous

MalaCards organs/tissues related to Platelet Aggregation, Spontaneous:

41
Whole Blood, Testes

Publications for Platelet Aggregation, Spontaneous

Articles related to Platelet Aggregation, Spontaneous:

(show all 18)
# Title Authors Year
1
[Effect of fibrin monomer on spontaneous platelet aggregation]. ( 21584967 )
2011
2
Soluble but not platelet P-selectin correlates with spontaneous platelet aggregation: a pilot study. ( 18252728 )
2008
3
Participation of IIb-IIIa glycoprotein in spontaneous platelet aggregation. ( 18214290 )
2007
4
Comparison of the effects of unfractionated heparin and the low-molecular-weight heparins dalteparin and enoxaparin on spontaneous platelet aggregation and adenosine diphosphate activity in platelets during the third trimester of pregnancy. ( 18040530 )
2007
5
Spontaneous platelet aggregation as a predictive risk factor for vascular occlusions in healthy volunteers? Results of the HAPARG Study. Haemostatic parameters as risk factors in healthy volunteers. ( 10381294 )
1999
6
Cutaneous vascular infarcts secondary to spontaneous platelet aggregation. ( 9747375 )
1998
7
Spontaneous platelet aggregation in whole blood is increased in non-insulin-dependent diabetes mellitus and in female but not male patients with primary dyslipidemia. ( 7772062 )
1995
8
Factors that contribute to spontaneous platelet aggregation and streptokinase-induced aggregation in whole blood. ( 7540774 )
1995
9
Increase in spontaneous platelet aggregation in beta-thalassemia/hemoglobin E disease: a consequence of splenectomy. ( 1298991 )
1992
10
Erythropoietin and spontaneous platelet aggregation in haemodialysis patients. ( 1682739 )
1991
11
[Measurement of spontaneous platelet aggregation in citrated whole blood by application of the hematologic automatic Coulter S plus VI]. ( 2068852 )
1991
12
Glucose increases spontaneous platelet aggregation in whole blood. ( 2122545 )
1990
13
Spontaneous platelet aggregation during pregnancy in a patient with von Willebrand disease type IIB can be blocked by monoclonal antibodies to both platelet glycoproteins Ib and IIb/IIIa. ( 2375928 )
1990
14
[Spontaneous platelet aggregation after experimental focal ischemia in the rabbit. "Sensitivity", "specificity" and value of the test used]. ( 2915816 )
1989
15
Different platelet binding sites are probably involved in spontaneous platelet aggregation induced by IIB von Willebrand factor in normals and in IIB von Willebrand's disease patients. ( 2803970 )
1989
16
In vivo antiaggregatory effect of BM 13.177 on the spontaneous platelet aggregation in anaesthetized beagle dogs. ( 3073773 )
1988
17
Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor. ( 2932469 )
1985
18
[Spontaneous platelet aggregation associated with administration of sex hormones in men and women (author's transl)]. ( 902586 )
1977

Variations for Platelet Aggregation, Spontaneous

Expression for Platelet Aggregation, Spontaneous

Search GEO for disease gene expression data for Platelet Aggregation, Spontaneous.

Pathways for Platelet Aggregation, Spontaneous

GO Terms for Platelet Aggregation, Spontaneous

Cellular components related to Platelet Aggregation, Spontaneous according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 CANT1 PLAT SERPINA3 SERPINC1 SERPINF2 SOD1
2 extracellular space GO:0005615 9.7 PF4 PLAT SELP SERPINA3 SERPINC1 SERPINF2
3 extracellular region GO:0005576 9.56 CANT1 PF4 PLAT SERPINA3 SERPINC1 SERPINF2
4 extracellular matrix GO:0031012 9.54 PLAT SOD1 VWF
5 blood microparticle GO:0072562 9.5 SERPINA3 SERPINC1 SERPINF2
6 platelet alpha granule lumen GO:0031093 8.92 PF4 SERPINA3 SERPINF2 VWF

Biological processes related to Platelet Aggregation, Spontaneous according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.5 PLAT SERPINC1 VWF
2 hemostasis GO:0007599 9.4 SERPINC1 VWF
3 acute-phase response GO:0006953 9.37 SERPINA3 SERPINF2
4 negative regulation of endopeptidase activity GO:0010951 9.33 SERPINA3 SERPINC1 SERPINF2
5 fibrinolysis GO:0042730 9.26 PLAT SERPINF2
6 negative regulation of peptidase activity GO:0010466 9.13 SERPINA3 SERPINC1 SERPINF2
7 platelet degranulation GO:0002576 9.1 PF4 SELP SERPINA3 SERPINF2 SOD1 VWF

Molecular functions related to Platelet Aggregation, Spontaneous according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.62 CANT1 SERPINF2 SOD1 VWF
2 heparin binding GO:0008201 9.43 PF4 SELP SERPINC1
3 peptidase inhibitor activity GO:0030414 9.33 SERPINA3 SERPINC1 SERPINF2
4 protease binding GO:0002020 9.13 SERPINC1 SERPINF2 VWF
5 serine-type endopeptidase inhibitor activity GO:0004867 8.8 SERPINA3 SERPINC1 SERPINF2

Sources for Platelet Aggregation, Spontaneous

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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