PG4D
MCID: PLT004
MIFTS: 45

Platelet Glycoprotein Iv Deficiency (PG4D)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Platelet Glycoprotein Iv Deficiency

MalaCards integrated aliases for Platelet Glycoprotein Iv Deficiency:

Name: Platelet Glycoprotein Iv Deficiency 57 12 74 29 13 6 72
Cd36 Deficiency 57 12 74 37
Bdplt10 57 12 74
Platelet-Type Bleeding Disorder 10 12 15
Bleeding Disorder, Platelet-Type, 10; Bdplt10 57
Bleeding Disorder, Platelet-Type, 10 57
Deficiency, Platelet Glycoprotein Iv 40
Bleeding Disorder Platelet-Type 10 74
Pg4d 74

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive

Miscellaneous:
two types of platelet gpiv deficiency - type i, absence gpiv on monocytes () and type ii, presence gpiv on monocytes ()


HPO:

32
platelet glycoprotein iv deficiency:
Inheritance autosomal dominant inheritance autosomal recessive inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0111046
KEGG 37 H01108
MeSH 44 D013921
MedGen 42 C1842090
UMLS 72 C1842090

Summaries for Platelet Glycoprotein Iv Deficiency

KEGG : 37
Human genetic platelet glycoprotein IV (CD36) deficiency may be related to the phenotypic expression of the metabolic syndrome and is frequently associated with atherosclerotic cardiovascular diseases. CD36 deficiency is relatively frequent in Asian and African populations. It also has been reported that CD36 deficiency might be linked with cardiomyopathy. This deficiency can be classified in two subgroups: the type I phenotype is characterized by platelets and monocytes/macrophages that exhibit CD36 deficiency; whereas in the type II phenotype, the surface expression of CD36 is lacking only in platelets, but expression is near normal in monocytes/macrophages.

MalaCards based summary : Platelet Glycoprotein Iv Deficiency, also known as cd36 deficiency, is related to atrial standstill 1 and hypertrophic cardiomyopathy. An important gene associated with Platelet Glycoprotein Iv Deficiency is CD36 (CD36 Molecule), and among its related pathways/superpathways are PPAR signaling pathway and Phagosome. Affiliated tissues include monocytes, neutrophil and heart, and related phenotypes are thrombocytopenia and abnormality of the endocrine system

Disease Ontology : 12 An inherited blood coagulation disease characterized by autosomal recessive inheritance of variable bleeding tendency, thrombocytopenia, giant platelets, and prolonged bleeding times that has material basis in homozygous or compound heterozygous mutation in the CD36 antigen gene on chromosome 7q21.

UniProtKB/Swiss-Prot : 74 Platelet glycoprotein IV deficiency: A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.

More information from OMIM: 608404 PS231200

Related Diseases for Platelet Glycoprotein Iv Deficiency

Graphical network of the top 20 diseases related to Platelet Glycoprotein Iv Deficiency:



Diseases related to Platelet Glycoprotein Iv Deficiency

Symptoms & Phenotypes for Platelet Glycoprotein Iv Deficiency

Human phenotypes related to Platelet Glycoprotein Iv Deficiency:

32
# Description HPO Frequency HPO Source Accession
1 thrombocytopenia 32 HP:0001873
2 abnormality of the endocrine system 32 HP:0000818
3 prolonged bleeding time 32 HP:0003010
4 giant platelets 32 HP:0001902

Symptoms via clinical synopsis from OMIM:

57
Hematology:
thrombocytopenia
giant platelets
variable bleeding tendencies
no neutrophil inclusions
low-to-normal platelet count (45 x 10(9)/l)
more

Clinical features from OMIM:

608404

MGI Mouse Phenotypes related to Platelet Glycoprotein Iv Deficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 ABCG1 CD36 GNPTAB PDK4 THBS1
2 hematopoietic system MP:0005397 9.8 ABCG1 CD36 GNPTAB PDK4 SCARB2 THBS1
3 growth/size/body region MP:0005378 9.77 ABCG1 CD36 GNPTAB SCARB2 THBS1
4 homeostasis/metabolism MP:0005376 9.73 ABCG1 CD36 GNPTAB PDK4 SCARB2 THBS1
5 immune system MP:0005387 9.63 ABCG1 CD36 GNPTAB PDK4 SCARB2 THBS1
6 renal/urinary system MP:0005367 9.35 ABCG1 CD36 GNPTAB SCARB2 THBS1
7 skeleton MP:0005390 9.02 ABCG1 CD36 GNPTAB PDK4 THBS1

Drugs & Therapeutics for Platelet Glycoprotein Iv Deficiency

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic and Cardiovascular Impact of CD36 Deficiency in African Americans Completed NCT02126735

Search NIH Clinical Center for Platelet Glycoprotein Iv Deficiency

Genetic Tests for Platelet Glycoprotein Iv Deficiency

Genetic tests related to Platelet Glycoprotein Iv Deficiency:

# Genetic test Affiliating Genes
1 Platelet Glycoprotein Iv Deficiency 29 CD36

Anatomical Context for Platelet Glycoprotein Iv Deficiency

MalaCards organs/tissues related to Platelet Glycoprotein Iv Deficiency:

41
Monocytes, Neutrophil, Heart, Brain, Smooth Muscle, Small Intestine, Lymph Node

Publications for Platelet Glycoprotein Iv Deficiency

Articles related to Platelet Glycoprotein Iv Deficiency:

(show top 50) (show all 157)
# Title Authors PMID Year
1
Human CD36 deficiency is associated with elevation in low-density lipoprotein-cholesterol. 38 8 71
10946357 2000
2
Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency. 38 8 71
7533783 1995
3
Malaria susceptibility and CD36 mutation. 8 71
10890433 2000
4
A novel polymorphism in glycoprotein IV (replacement of proline-90 by serine) predominates in subjects with platelet GPIV deficiency. 8 71
7686693 1993
5
Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. 38 71
18305138 2008
6
Attenuated aerobic exercise capacity in CD36 deficiency. 38 8
17412877 2007
7
Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency. 38 71
11950861 2002
8
Analyses of genetic abnormalities in type I CD36 deficiency in Japan: identification and cell biological characterization of two novel mutations that cause CD36 deficiency in man. 38 8
11499670 2001
9
CD36 deficiency associated with insulin resistance. 38 8
11247555 2001
10
CD36 deficiency is frequent and can cause platelet immunization in Africans. 38 8
10504124 1999
11
Is CD36 deficiency an etiology of hereditary hypertrophic cardiomyopathy? 38 8
9040027 1997
12
A single nucleotide insertion in codon 317 of the CD36 gene leads to CD36 deficiency. 38 71
8696942 1996
13
Platelet glycoprotein IV (CD36) deficiency is associated with the absence (type I) or the presence (type II) of glycoprotein IV on monocytes. 38 8
7506948 1994
14
CD36 polymorphism is associated with protection from cerebral malaria. 71
12506336 2003
15
Incidence of the Nak(a)-negative platelet phenotype in African Americans is similar to that of Asians. 8
8623134 1996
16
Frequency of human platelet antigens among blood donors in northeastern Thailand. 8
7570919 1995
17
A platelet membrane glycoprotein (GP) deficiency in healthy blood donors: Naka- platelets lack detectable GPIV (CD36). 8
1699620 1990
18
Familial macrothrombocytopenia associated with decreased glycosylation of platelet membrane glycoprotein IV. 8
2316511 1990
19
Identification of the platelet-specific alloantigen, Naka, on platelet membrane glycoprotein IV. 8
2297570 1990
20
A new platelet-specific antigen, Naka, involved in the refractoriness of HLA-matched platelet transfusion. 8
2617957 1989
21
A single-center investigational study of CD36 antigen deficiency and platelet alloantibody distribution in different populations in Northern China as well as platelet alloantibodies effect on pregnancy. 38
31421121 2019
22
A string of 12 mutations in Intron 3 is a new clue associated with Type II CD36 deficiency. 38
30840330 2019
23
Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways. 38
30738832 2019
24
CD36 Enhances Vascular Smooth Muscle Cell Proliferation and Development of Neointimal Hyperplasia. 38
30567481 2019
25
[Construction of eukaryotic expression vector for human platelet CD36 gene 220C>T and 429+4insg variants and analysis of their expressions in HEK293T cells]. 38
30703228 2019
26
2-Year follow-up of a patient with CD36 deficiency and takotsubo cardiomyopathy. 38
30187241 2018
27
CD36 and lipid metabolism in the evolution of atherosclerosis. 38
29534172 2018
28
Treatment with medium chain fatty acids milk of CD36-deficient preschool children. 38
29524782 2018
29
CD36 deficiency attenuates immune-mediated hepatitis in mice by modulating the proapoptotic effects of CXC chemokine ligand 10. 38
29220536 2018
30
[Anti-CD36 Mediated Platelet Transfusion Refractoriness and Related Cases After Stem Cell Transplantation]. 38
29665929 2018
31
Successful management of a hydropic fetus with severe anemia and thrombocytopenia caused by anti-CD36 antibody. 38
28815406 2018
32
Fetal/neonatal alloimmune thrombocytopenia due to anti-CD36 antibodies: antibody evaluations by CD36-transfected cell lines. 38
29030871 2018
33
CD36 Deficiency Suppresses Epileptic Seizures. 38
29111364 2017
34
Cluster of Differentiation 36 Deficiency Aggravates Macrophage Infiltration and Hepatic Inflammation by Upregulating Monocyte Chemotactic Protein-1 Expression of Hepatocytes Through Histone Deacetylase 2-Dependent Pathway. 38
27967209 2017
35
Inflammatory stress promotes the development of obesity-related chronic kidney disease via CD36 in mice. 38
28536108 2017
36
Activation of PPARĪ³ does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI. 38
27890613 2017
37
CD36 deficiency impairs the small intestinal barrier and induces subclinical inflammation in mice. 38
28066800 2017
38
[A novel CD36 mutation T538C (Trp180Arg) results in CD36 deficiency and establishment of a genotyping method for the novel mutation based on sequence-specific primer PCR]. 38
27577207 2016
39
Alterations in the cardiac proteome of the spontaneously hypertensive rat induced by transgenic expression of CD36. 38
27132684 2016
40
[CD36 Antigen Deficiency and Platelet Transfusion]. 38
27342537 2016
41
LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic Reprogramming. 38
27013613 2016
42
Genetic variations of CD36 and low platelet CD36 expression - a risk factor for lipemic plasma donation in Taiwanese apheresis donors. 38
26528880 2016
43
Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart. 38
27195707 2016
44
Microarray Integrated Analysis of a Gene Network for the CD36 Myocardial Phenotype. 38
28293076 2016
45
CD36 deficiency blunts effects of diet on regulatory T cells in murine gonadal adipose tissue and mesenteric lymph nodes. 38
26344897 2015
46
Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice. 38
26130608 2015
47
Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice. 38
26036798 2015
48
Targeting CD36-mediated inflammation reduces acute brain injury in transient, but not permanent, ischemic stroke. 38
25216018 2015
49
Incidence and molecular basis of CD36 deficiency in Shanghai population. 38
25330908 2015
50
Free fatty acid uptake in humans with CD36 deficiency. 38
24917573 2014

Variations for Platelet Glycoprotein Iv Deficiency

ClinVar genetic disease variations for Platelet Glycoprotein Iv Deficiency:

6 (show top 50) (show all 56)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 CD36 NM_001001547.2(CD36): c.120+399TG[12] short repeat Pathogenic,protective 7:80276575-80276575 7:80647259-80647259
2 CD36 CD36, G1439C, 1-BP DEL, 1444A deletion Pathogenic,risk factor
3 CD36 NM_001001547.3(CD36): c.268C> T (p.Pro90Ser) single nucleotide variant Pathogenic rs75326924 7:80286003-80286003 7:80656687-80656687
4 CD36 NM_001001547.3(CD36): c.760T> C (p.Phe254Leu) single nucleotide variant Pathogenic rs142186404 7:80299280-80299280 7:80669964-80669964
5 CD36 NM_001001547.3(CD36): c.1237A> C (p.Ile413Leu) single nucleotide variant Pathogenic rs121918035 7:80302708-80302708 7:80673392-80673392
6 CD36 NM_001001547.3(CD36): c.330_331CA[1] (p.Thr111fs) short repeat Pathogenic rs572295823 7:80290429-80290430 7:80661113-80661114
7 CD36 NM_001001547.3(CD36): c.1228_1239del (p.Ile410_Ile413del) deletion Pathogenic/Likely pathogenic rs550565800 7:80302699-80302710 7:80673383-80673394
8 CD36 NM_001001547.3(CD36): c.429+2T> C single nucleotide variant Likely pathogenic rs3211893 7:80290528-80290528 7:80661212-80661212
9 CD36 NM_001001547.3(CD36): c.949dup (p.Ile317fs) duplication Likely pathogenic rs70961716 7:80300423-80300423 7:80671107-80671107
10 CD36 NM_001001547.3(CD36): c.1156C> T (p.Arg386Trp) single nucleotide variant Likely pathogenic 7:80302116-80302116 7:80672800-80672800
11 CD36 NM_001001547.3(CD36): c.1297_1301del (p.Gln433fs) deletion Uncertain significance 7:80303336-80303341 7:80674025-80674029
12 CD36 NM_001001547.3(CD36): c.430-2A> G single nucleotide variant Uncertain significance 7:80292304-80292304 7:80662988-80662988
13 CD36 NM_001001547.3(CD36): c.609+1G> A single nucleotide variant Uncertain significance 7:80292486-80292486 7:80663170-80663170
14 CD36 NM_001001547.2(CD36): c.701+1delG deletion Uncertain significance 7:80293812-80293813 7:80664498-80664498
15 CD36 NM_001001547.2(CD36): c.1126-5_1127delTTTAGAT deletion Uncertain significance 7:80302079-80302086 7:80672765-80672771
16 CD36 NM_001001547.3(CD36): c.-325G> A single nucleotide variant Uncertain significance rs886062448 7:80231554-80231554 7:80602238-80602238
17 CD36 NM_001001547.3(CD36): c.-208C> T single nucleotide variant Uncertain significance rs886062451 7:80231671-80231671 7:80602355-80602355
18 CD36 NM_001001547.3(CD36): c.-27C> T single nucleotide variant Uncertain significance rs768286621 7:80276030-80276030 7:80646714-80646714
19 CD36 NM_001001547.3(CD36): c.265G> T (p.Gly89Cys) single nucleotide variant Uncertain significance rs374729345 7:80286000-80286000 7:80656684-80656684
20 CD36 NM_001001547.3(CD36): c.649G> A (p.Gly217Arg) single nucleotide variant Uncertain significance rs200067322 7:80293761-80293761 7:80664445-80664445
21 CD36 NM_001001547.3(CD36): c.853C> T (p.Leu285=) single nucleotide variant Uncertain significance rs780267115 7:80300327-80300327 7:80671011-80671011
22 CD36 NM_001001547.3(CD36): c.1125+13C> A single nucleotide variant Uncertain significance rs3211942 7:80301369-80301369 7:80672053-80672053
23 CD36 NM_001001547.3(CD36): c.220C> T (p.Gln74Ter) single nucleotide variant Uncertain significance 7:80285955-80285955 7:80656639-80656639
24 CD36 NM_001001547.3(CD36): c.380C> G (p.Ser127Ter) single nucleotide variant Uncertain significance 7:80290477-80290477 7:80661161-80661161
25 CD36 NM_001001547.3(CD36): c.1079T> G (p.Leu360Ter) single nucleotide variant Uncertain significance 7:80301310-80301310 7:80671994-80671994
26 CD36 NM_001001547.3(CD36): c.1112_1119dup (p.Glu374fs) duplication Uncertain significance 7:80301341-80301341 7:80672027-80672034
27 CD36 NM_001001547.3(CD36): c.1254+1G> A single nucleotide variant Uncertain significance rs148051111 7:80302726-80302726 7:80673410-80673410
28 CD36 NM_001001547.3(CD36): c.-211C> T single nucleotide variant Uncertain significance rs151218598 7:80231668-80231668 7:80602352-80602352
29 CD36 NM_001001547.3(CD36): c.-209C> T single nucleotide variant Uncertain significance rs539733007 7:80231670-80231670 7:80602354-80602354
30 CD36 NM_001001547.3(CD36): c.282-14T> A single nucleotide variant Uncertain significance rs754938089 7:80290365-80290365 7:80661049-80661049
31 CD36 NM_001001547.3(CD36): c.682G> A (p.Asp228Asn) single nucleotide variant Uncertain significance rs774794181 7:80293794-80293794 7:80664478-80664478
32 CD36 NM_001001547.3(CD36): c.*47A> G single nucleotide variant Uncertain significance rs759397538 7:80303510-80303510 7:80674194-80674194
33 CD36 NM_001001547.3(CD36): c.159T> C (p.Asn53=) single nucleotide variant Uncertain significance rs886062452 7:80285894-80285894 7:80656578-80656578
34 CD36 NM_001001547.3(CD36): c.390A> T (p.Thr130=) single nucleotide variant Uncertain significance rs148114593 7:80290487-80290487 7:80661171-80661171
35 CD36 NM_001001547.3(CD36): c.1133G> T (p.Gly378Val) single nucleotide variant Uncertain significance rs146027667 7:80302093-80302093 7:80672777-80672777
36 CD36 NM_001001547.3(CD36): c.1220_1222del (p.Arg407del) deletion Uncertain significance rs773274847 7:80302691-80302693 7:80673375-80673377
37 CD36 NM_001001547.3(CD36): c.*202G> T single nucleotide variant Uncertain significance rs143304806 7:80303665-80303665 7:80674349-80674349
38 CD36 NM_001001547.3(CD36): c.*226A> G single nucleotide variant Uncertain significance rs8956 7:80303689-80303689 7:80674373-80674373
39 CD36 NM_001001547.3(CD36): c.-286C> A single nucleotide variant Uncertain significance rs886062450 7:80231593-80231593 7:80602277-80602277
40 CD36 NM_001001547.3(CD36): c.374C> T (p.Ser125Leu) single nucleotide variant Uncertain significance rs886062453 7:80290471-80290471 7:80661155-80661155
41 CD36 NM_001001547.3(CD36): c.405C> G (p.Phe135Leu) single nucleotide variant Uncertain significance rs747515126 7:80290502-80290502 7:80661186-80661186
42 CD36 NM_001001547.3(CD36): c.429+15A> G single nucleotide variant Uncertain significance rs371196837 7:80290541-80290541 7:80661225-80661225
43 CD36 NM_001001547.3(CD36): c.456A> G (p.Gln152=) single nucleotide variant Uncertain significance rs543785881 7:80292332-80292332 7:80663016-80663016
44 CD36 NM_001001547.3(CD36): c.640G> A (p.Val214Ile) single nucleotide variant Uncertain significance rs190735330 7:80293752-80293752 7:80664436-80664436
45 CD36 NM_001001547.3(CD36): c.1000A> G (p.Lys334Glu) single nucleotide variant Uncertain significance rs199628571 7:80300474-80300474 7:80671158-80671158
46 CD36 NM_001001547.3(CD36): c.1126-15T> C single nucleotide variant Uncertain significance rs758766716 7:80302071-80302071 7:80672755-80672755
47 CD36 NM_001001547.3(CD36): c.1181_1185dup (p.Glu397fs) duplication Uncertain significance rs757570230 7:80302141-80302145 7:80672825-80672829
48 CD36 NM_001001547.3(CD36): c.1279G> T (p.Ala427Ser) single nucleotide variant Uncertain significance rs201527696 7:80303323-80303323 7:80674007-80674007
49 CD36 NM_001001547.3(CD36): c.-297G> A single nucleotide variant Uncertain significance rs886062449 7:80231582-80231582 7:80602266-80602266
50 CD36 NM_001001547.3(CD36): c.-150T> A single nucleotide variant Uncertain significance rs532897983 7:80275437-80275437 7:80646121-80646121

UniProtKB/Swiss-Prot genetic disease variations for Platelet Glycoprotein Iv Deficiency:

74
# Symbol AA change Variation ID SNP ID
1 CD36 p.Pro90Ser VAR_017913 rs75326924
2 CD36 p.Phe254Leu VAR_017917 rs142186404
3 CD36 p.Ile413Leu VAR_017919 rs121918035

Expression for Platelet Glycoprotein Iv Deficiency

Search GEO for disease gene expression data for Platelet Glycoprotein Iv Deficiency.

Pathways for Platelet Glycoprotein Iv Deficiency

Pathways related to Platelet Glycoprotein Iv Deficiency according to KEGG:

37
# Name Kegg Source Accession
1 PPAR signaling pathway hsa03320
2 Phagosome hsa04145
3 Adipocytokine signaling pathway hsa04920
4 Fat digestion and absorption hsa04975

Pathways related to Platelet Glycoprotein Iv Deficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 THBS1 CD36
2
Show member pathways
11.35 THBS1 CD36
3 11.05 SCARB2 GNPTAB
4 10.31 THBS1 CD36

GO Terms for Platelet Glycoprotein Iv Deficiency

Cellular components related to Platelet Glycoprotein Iv Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.16 THBS1 CD36
2 Golgi membrane GO:0000139 9.13 SCARB2 GNPTAB ABCG1
3 external side of plasma membrane GO:0009897 8.8 THBS1 CD36 ABCG1

Biological processes related to Platelet Glycoprotein Iv Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.32 THBS1 CD36
2 positive regulation of reactive oxygen species metabolic process GO:2000379 9.26 THBS1 CD36
3 cholesterol transport GO:0030301 9.16 CD36 ABCG1
4 response to lipid GO:0033993 8.96 CD36 ABCG1
5 positive regulation of blood coagulation GO:0030194 8.62 THBS1 CD36

Molecular functions related to Platelet Glycoprotein Iv Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scavenger receptor activity GO:0005044 9.16 SCARB2 CD36
2 transforming growth factor beta binding GO:0050431 8.96 THBS1 CD36
3 low-density lipoprotein particle binding GO:0030169 8.62 THBS1 CD36

Sources for Platelet Glycoprotein Iv Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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