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PMF
MCID: PLT031
MIFTS: 28

Platelet Membrane Fluidity (PMF)

Categories: Blood diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Platelet Membrane Fluidity

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MalaCards integrated aliases for Platelet Membrane Fluidity:

Name: Platelet Membrane Fluidity 57 39
Pmf 57

Classifications:

MalaCards categories:
Anatomical: Blood diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM® 57 173560
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Summaries for Platelet Membrane Fluidity

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MalaCards based summary : Platelet Membrane Fluidity, also known as pmf, is related to cerebral artery occlusion and hypertension, essential. An important gene associated with Platelet Membrane Fluidity is NOS2 (Nitric Oxide Synthase 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and VEGF Signaling. Affiliated tissues include whole blood, heart and myeloid, and related phenotypes are liver/biliary system and renal/urinary system

More information from OMIM: 173560
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Related Diseases for Platelet Membrane Fluidity

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Diseases related to Platelet Membrane Fluidity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 cerebral artery occlusion 29.4 NOS3 NOS2
2 hypertension, essential 29.4 SELP NOS3 NOS2
3 ischemia 29.0 SELP NOS3 NOS2
4 myelofibrosis 11.2
5 essential thrombocythemia 11.0
6 polycythemia vera 11.0
7 alzheimer disease 10.2
8 polycythemia 10.2
9 splenomegaly 10.2
10 migraine with or without aura 1 10.2
11 eales disease 10.2
12 myeloproliferative neoplasm 10.1
13 hypercholesterolemia, familial, 1 10.0
14 hypertriglyceridemia, familial 10.0
15 down syndrome 10.0
16 migraine without aura 10.0
17 uremia 10.0
18 cerebrovascular disease 10.0
19 vascular dementia 10.0
20 binswanger's disease 10.0
21 headache 10.0
22 urinary tract infection 10.0
23 constipation 10.0
24 fibrosarcoma 10.0
25 proteasome-associated autoinflammatory syndrome 1 9.9 SELP NOS2
26 peripheral vascular disease 9.9 SELP NOS2
27 fibrosis of extraocular muscles, congenital, 1 9.8
28 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
29 chronic myelomonocytic leukemia 9.8
30 covid-19 9.8
31 pyelonephritis 9.8
32 hemosiderosis 9.8
33 thrombocytopenia 9.8
34 thrombocytosis 9.8
35 alopecia 9.8
36 47,xyy 9.8
37 dentinogenesis imperfecta type 2 9.8
38 rapidly involuting congenital hemangioma 9.8
39 rare hereditary hemochromatosis 9.8
40 argyria 9.8
41 carotid artery thrombosis 9.8 SELP NOS3
42 carotid stenosis 9.8 SELP NOS3
43 peripheral artery disease 9.8 SELP NOS3
44 sickle cell disease 9.8 SELP NOS3
45 priapism 9.8 NOS3 NOS2
46 hepatopulmonary syndrome 9.8 NOS3 NOS2
47 diabetic polyneuropathy 9.8 NOS3 NOS2
48 diabetic angiopathy 9.8 NOS3 NOS2
49 varicocele 9.8 NOS3 NOS2
50 impotence 9.8 NOS3 NOS2

Graphical network of the top 20 diseases related to Platelet Membrane Fluidity:



Diseases related to Platelet Membrane Fluidity
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Symptoms & Phenotypes for Platelet Membrane Fluidity

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Clinical features from OMIM®:

173560 (Updated 05-Mar-2021)

MGI Mouse Phenotypes related to Platelet Membrane Fluidity:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.33 NOS2 NOS3 SELP
2 renal/urinary system MP:0005367 9.13 NOS2 NOS3 SELP
3 respiratory system MP:0005388 8.8 NOS2 NOS3 SELP
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Drugs & Therapeutics for Platelet Membrane Fluidity

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Search Clinical Trials , NIH Clinical Center for Platelet Membrane Fluidity

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Genetic Tests for Platelet Membrane Fluidity

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Anatomical Context for Platelet Membrane Fluidity

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MalaCards organs/tissues related to Platelet Membrane Fluidity:

40
Whole Blood, Heart, Myeloid
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Publications for Platelet Membrane Fluidity

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Articles related to Platelet Membrane Fluidity:

(show top 50) (show all 94)
# Title Authors PMID Year
1
Platelet membrane fluidity individuals at risk for Alzheimer's disease: a comparison of results from fluorescence spectroscopy and electron spin resonance spectroscopy. 57 61
10463318 1999
2
Inheritance pattern of platelet membrane fluidity in Alzheimer disease. 61 57
2729275 1989
3
Longitudinal study of platelet membrane fluidity in Alzheimer's disease. 61 57
3233233 1988
4
Family study of platelet membrane fluidity in Alzheimer's disease. 57 61
3659926 1987
5
Mechanisms of the antiplatelet and analgesic effects of dextromethorphan and its metabolites. 61
32269947 2020
6
Suicidal behaviour is associated with decreased esterified cholesterol in plasma and membrane fluidity of platelets. 61
29222984 2018
7
Effect of 1-y oral supplementation with vitaminized olive oil on platelets from healthy postmenopausal women. 61
28870486 2017
8
Hemorrhagic risk due to platelet dysfunction in myelodysplastic patients, correlations with anemia severity and iron overload. 61
25811447 2015
9
Assessment of changes in membrane properties of platelets from patients with chronic myeloid leukaemia in different stages of the disease. 61
24346354 2014
10
Ultrastructural changes in platelet membranes due to cigarette smoking. 61
22849525 2012
11
Alterations of platelet biochemical and functional properties in newly diagnosed type 1 diabetes: a role in cardiovascular risk? 61
21309054 2011
12
Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales' disease). 61
20973744 2010
13
Antiplatelet activity of alpha-lipoic acid. 61
20681648 2010
14
Smoking-induced alterations in platelet membrane fluidity and Na(+)/K(+)-ATPase activity in chronic cigarette smokers. 61
20154447 2010
15
Platelet membrane fluidity and Na+/K+ ATPase activity in acute stroke. 61
18343354 2008
16
Plasma triglycerides as predictors of platelet responsiveness to aspirin in patients after first ischemic stroke. 61
18648200 2008
17
Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidity. 61
16933035 2006
18
Decreased platelet membrane fluidity in retinal periphlebitis in Eales' disease. 61
16597541 2006
19
Mechanisms involved in the antiplatelet effect of C-phycocyanin. 61
16469164 2006
20
Platelet membrane fluidity and peroxynitrite levels in migraine patients during headache-free periods. 61
15839850 2005
21
Mechanisms involved in the antiplatelet activity of ketamine in human platelets. 61
15591773 2004
22
Cytochrome c oxidase is decreased in Alzheimer's disease platelets. 61
14675736 2004
23
Blood platelet membrane fluidity and the exposition of membrane protein receptors in Alzheimer disease (AD) patients--preliminary Study. 61
11882750 2002
24
[Platelet membrane fluidity and receptor exposition in patients with Alzheimer's disease]. 61
10791030 1999
25
Platelet membrane fluidity in non-insulin-dependent diabetes mellitus (NIDDM) subjects, in subjects with vascular atherosclerotic disease (VAD) and in VAD subjects with NIDDM. 61
10456470 1999
26
Effects of apolipoprotein E genotype on blood lipid composition and membrane platelet fluidity in Alzheimer's disease. 61
10354518 1999
27
Release of calcium and P-selectin from intraplatelet granules is hampered by procaine. 61
10213176 1999
28
Possible mechanisms of the altered platelet volume distribution in type 2 diabetes: does increased platelet activation contribute to platelet size heterogeneity? 61
16801071 1999
29
Prospective study of risk factors for Alzheimer's disease: results at 7.5 years. 61
9892297 1999
30
Association of age-related decrease in platelet membrane fluidity with platelet lipid peroxide. 61
10069491 1999
31
Inhibitory effect of Ginkgo biloba extract on human platelet aggregation. 61
16801106 1999
32
Effects of dietary marine oils and olive oil on fatty acid composition, platelet membrane fluidity, platelet responses, and serum lipids in healthy humans. 61
9590631 1998
33
Membrane lipid fluidity of blood platelets: a common denominator that underlies the opposing actions of various agents that affect platelet activation in whole blood. 61
16793756 1998
34
Erythrocyte, platelet and polymorphonuclear leukocyte membrane dynamic properties in essential hypertension. 61
9356784 1997
35
Platelet membrane fluidity and intraplatelet Ca2+ mobilization are affected in uraemia. 61
9222291 1997
36
Platelet membrane fluidity and intraplatelet Ca2+ homeostasis are affected in uremia. 61
9112666 1996
37
Prospective study of increased platelet membrane fluidity as a risk factor for Alzheimer's disease: results at 5 years. 61
8610834 1996
38
Diabetes mellitus alters the effect of peptide and protein ligands on membrane fluidity of blood platelets. 61
8713794 1996
39
Does reduced membrane lipid fluidity underlie the altered thrombin-induced expression of integrin α(IIb)β(3) and PADGEM-140 in membranes of platelets from diabetic juveniles? 61
21043597 1996
40
Cytosolic Ca2+ content and membrane fluidity of platelets and polymorphonuclear leucocytes in diabetes mellitus. 61
7590622 1995
41
Membrane fluidity, membrane lipid pattern, and cytosolic Ca2+ content in platelets from a group of type II diabetic patients with macrovascular complications. 61
7698049 1995
42
Aspirin-induced conformational changes in platelet membrane in subjects with stroke. 61
7557498 1995
43
Platelet membrane fluidity and platelet membrane lipid pattern in essential hypertension. 61
7734103 1995
44
Lipid peroxidation and platelet membrane fluidity--implications for Alzheimer's disease? 61
7881031 1994
45
Effects of chronic administration of ethanol on platelets from rabbits with diet-induced hypercholesterolemia. Unchanged characteristics and responses to ADP but reduction of enhanced thrombin-induced, TxA2-independent platelet responses. 61
8049200 1994
46
Platelet membrane fluidity and plasma malondialdehyde levels in Alzheimer's demented patients with and without family history of dementia. 61
8173019 1994
47
[The composition of fatty acids in individual classes of blood platelet phospholipids of patients with uremia]. 61
8367371 1993
48
Changes in platelet membrane fluidity of migraine patients. 61
8495463 1993
49
Plasma lipids and platelet membrane fluidity in essential hypertension. 61
8383361 1993
50
Lipid fluidity modulates platelet aggregation and agglutination in vitro. 61
8366768 1993
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Variations for Platelet Membrane Fluidity

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Expression for Platelet Membrane Fluidity

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Search GEO for disease gene expression data for Platelet Membrane Fluidity.
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Pathways for Platelet Membrane Fluidity

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Pathways related to Platelet Membrane Fluidity according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 12.79 SELP NOS3 NOS2
2
VEGF Signaling 66
Show member pathways
 12.06 NOS3 NOS2
3
Prolactin Signaling Pathway 1 36
Show member pathways
 12.04 NOS3 NOS2
4
Insulin receptor recycling 65
Show member pathways
 12.03 NOS3 NOS2
5
Development VEGF signaling via VEGFR2 - generic cascades 23
Show member pathways
 11.96 NOS3 NOS2
6
Calcium signaling pathway 36
11.95 NOS3 NOS2
7
Platelet homeostasis 65
Show member pathways
 11.83 NOS3 NOS2
8
AMPK Enzyme Complex Pathway 63
Show member pathways
 11.78 NOS3 NOS2
9
Apelin signaling pathway 36
11.66 NOS3 NOS2
10
Spinal Cord Injury 1
11.59 SELP NOS2
11
HIF-1 signaling pathway 36
11.53 NOS3 NOS2
12
AGE/RAGE pathway 1
11.3 NOS3 NOS2
13
Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) 23
Show member pathways
 11.23 NOS3 NOS2
14
Arginine and proline metabolism 36
Show member pathways
 11.2 NOS3 NOS2
15
Nitric oxide stimulates guanylate cyclase 65
Show member pathways
 11.03 NOS3 NOS2
16
Doxorubicin Pathway, Pharmacokinetics 60
Show member pathways
 10.97 NOS3 NOS2
17
Ibuprofen Pathway, Pharmacodynamics 60
10.77 NOS3 NOS2
18
Arginine biosynthesis 36
Show member pathways
 10.69 NOS3 NOS2
19
Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics 60
10.54 NOS3 NOS2
20
NO-dependent CFTR activation (normal and CF) 23
10.07 NOS3 NOS2
21
Effects of Nitric Oxide 1
9.53 NOS3 NOS2
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GO Terms for Platelet Membrane Fluidity

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Cellular components related to Platelet Membrane Fluidity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle membrane GO:0012506 8.62 NOS3 NOS2

Biological processes related to Platelet Membrane Fluidity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-negative bacterium GO:0050829 9.46 SELP NOS2
2 cell redox homeostasis GO:0045454 9.43 NOS3 NOS2
3 response to hormone GO:0009725 9.4 NOS3 NOS2
4 negative regulation of blood pressure GO:0045776 9.37 NOS3 NOS2
5 nitric oxide mediated signal transduction GO:0007263 9.32 NOS3 NOS2
6 nitric oxide biosynthetic process GO:0006809 9.26 NOS3 NOS2
7 positive regulation of guanylate cyclase activity GO:0031284 9.16 NOS3 NOS2
8 response to lipopolysaccharide GO:0032496 9.13 SELP NOS3 NOS2
9 arginine catabolic process GO:0006527 8.62 NOS3 NOS2

Molecular functions related to Platelet Membrane Fluidity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.48 NOS3 NOS2
2 heme binding GO:0020037 9.46 NOS3 NOS2
3 flavin adenine dinucleotide binding GO:0050660 9.43 NOS3 NOS2
4 NADP binding GO:0050661 9.4 NOS3 NOS2
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.37 NOS3 NOS2
6 FMN binding GO:0010181 9.32 NOS3 NOS2
7 arginine binding GO:0034618 9.26 NOS3 NOS2
8 NADPH-hemoprotein reductase activity GO:0003958 9.16 NOS3 NOS2
9 tetrahydrobiopterin binding GO:0034617 8.96 NOS3 NOS2
10 nitric-oxide synthase activity GO:0004517 8.62 NOS3 NOS2
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Sources for Platelet Membrane Fluidity

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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