MCID: PLT031
MIFTS: 29

Platelet Membrane Fluidity

Categories: Blood diseases

Aliases & Classifications for Platelet Membrane Fluidity

MalaCards integrated aliases for Platelet Membrane Fluidity:

Name: Platelet Membrane Fluidity 57 40
Pmf 57 3

Classifications:



External Ids:

OMIM 57 173560

Summaries for Platelet Membrane Fluidity

CDC : 3 Fellows in the PMF Program at CDC attending a mentoring session with Dr. Tom Frieden, Former CDC Director. Atlanta, GA (2015)

MalaCards based summary : Platelet Membrane Fluidity, also known as pmf, is related to hypertension, essential and myelofibrosis. An important gene associated with Platelet Membrane Fluidity is NOS2 (Nitric Oxide Synthase 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Prolactin Signaling Pathway. Related phenotypes are liver/biliary system and renal/urinary system

Description from OMIM: 173560

Related Diseases for Platelet Membrane Fluidity

Graphical network of the top 20 diseases related to Platelet Membrane Fluidity:



Diseases related to Platelet Membrane Fluidity

Symptoms & Phenotypes for Platelet Membrane Fluidity

Clinical features from OMIM:

173560

MGI Mouse Phenotypes related to Platelet Membrane Fluidity:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.43 NOS2 NOS3 SELP
2 renal/urinary system MP:0005367 9.33 NOS2 NOS3 SELP
3 respiratory system MP:0005388 9.13 NOS2 NOS3 SELP
4 vision/eye MP:0005391 8.8 NOS2 NOS3 SELP

Drugs & Therapeutics for Platelet Membrane Fluidity

Search Clinical Trials , NIH Clinical Center for Platelet Membrane Fluidity

Genetic Tests for Platelet Membrane Fluidity

Anatomical Context for Platelet Membrane Fluidity

Publications for Platelet Membrane Fluidity

Articles related to Platelet Membrane Fluidity:

(show all 22)
# Title Authors Year
1
Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales' disease). ( 20973744 )
2010
2
Smoking-induced alterations in platelet membrane fluidity and Na(+)/K(+)-ATPase activity in chronic cigarette smokers. ( 20154447 )
2010
3
Platelet membrane fluidity and Na+/K+ ATPase activity in acute stroke. ( 18343354 )
2008
4
Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidity. ( 16933035 )
2006
5
Decreased platelet membrane fluidity in retinal periphlebitis in Eales' disease. ( 16597541 )
2006
6
Platelet membrane fluidity and peroxynitrite levels in migraine patients during headache-free periods. ( 15839850 )
2005
7
Blood platelet membrane fluidity and the exposition of membrane protein receptors in Alzheimer disease (AD) patients--preliminary Study. ( 11882750 )
2002
8
Platelet membrane fluidity individuals at risk for Alzheimer's disease: a comparison of results from fluorescence spectroscopy and electron spin resonance spectroscopy. ( 10463318 )
1999
9
[Platelet membrane fluidity and receptor exposition in patients with Alzheimer's disease]. ( 10791030 )
1999
10
Platelet membrane fluidity in non-insulin-dependent diabetes mellitus (NIDDM) subjects, in subjects with vascular atherosclerotic disease (VAD) and in VAD subjects with NIDDM. ( 10456470 )
1999
11
Association of age-related decrease in platelet membrane fluidity with platelet lipid peroxide. ( 10069491 )
1999
12
Effects of dietary marine oils and olive oil on fatty acid composition, platelet membrane fluidity, platelet responses, and serum lipids in healthy humans. ( 9590631 )
1998
13
Platelet membrane fluidity and intraplatelet Ca2+ mobilization are affected in uraemia. ( 9222291 )
1997
14
Platelet membrane fluidity and intraplatelet Ca2+ homeostasis are affected in uremia. ( 9112666 )
1996
15
Prospective study of increased platelet membrane fluidity as a risk factor for Alzheimer's disease: results at 5 years. ( 8610834 )
1996
16
Platelet membrane fluidity and platelet membrane lipid pattern in essential hypertension. ( 7734103 )
1995
17
Platelet membrane fluidity and plasma malondialdehyde levels in Alzheimer's demented patients with and without family history of dementia. ( 8173019 )
1994
18
Lipid peroxidation and platelet membrane fluidity--implications for Alzheimer's disease? ( 7881031 )
1994
19
Platelet membrane fluidity. ( 8423903 )
1993
20
Changes in platelet membrane fluidity of migraine patients. ( 8495463 )
1993
21
Plasma lipids and platelet membrane fluidity in essential hypertension. ( 8383361 )
1993
22
Inheritance pattern of platelet membrane fluidity in Alzheimer disease. ( 2729275 )
1989

Variations for Platelet Membrane Fluidity

Expression for Platelet Membrane Fluidity

Search GEO for disease gene expression data for Platelet Membrane Fluidity.

Pathways for Platelet Membrane Fluidity

Pathways related to Platelet Membrane Fluidity according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 NOS2 NOS3 SELP
2
Show member pathways
12.04 NOS2 NOS3
3
Show member pathways
12.03 NOS2 NOS3
4
Show member pathways
11.96 NOS2 NOS3
5
Show member pathways
11.84 NOS2 NOS3
6
Show member pathways
11.83 NOS2 NOS3
7
Show member pathways
11.78 NOS2 NOS3
8 11.66 NOS2 NOS3
9 11.59 NOS2 SELP
10 11.49 NOS2 NOS3
11 11.3 NOS2 NOS3
12
Show member pathways
11.23 NOS2 NOS3
13
Show member pathways
11.19 NOS2 NOS3
14
Show member pathways
11.03 NOS2 NOS3
15
Show member pathways
10.97 NOS2 NOS3
16 10.77 NOS2 NOS3
17
Show member pathways
10.67 NOS2 NOS3
18 10.54 NOS2 NOS3
19 10.07 NOS2 NOS3
20 9.53 NOS2 NOS3

GO Terms for Platelet Membrane Fluidity

Cellular components related to Platelet Membrane Fluidity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle membrane GO:0012506 8.62 NOS2 NOS3

Biological processes related to Platelet Membrane Fluidity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-negative bacterium GO:0050829 9.48 NOS2 SELP
2 cell redox homeostasis GO:0045454 9.46 NOS2 NOS3
3 response to hormone GO:0009725 9.43 NOS2 NOS3
4 negative regulation of blood pressure GO:0045776 9.4 NOS2 NOS3
5 positive regulation of blood vessel diameter GO:0097755 9.37 NOS2 NOS3
6 nitric oxide mediated signal transduction GO:0007263 9.32 NOS2 NOS3
7 nitric oxide biosynthetic process GO:0006809 9.26 NOS2 NOS3
8 positive regulation of guanylate cyclase activity GO:0031284 9.16 NOS2 NOS3
9 response to lipopolysaccharide GO:0032496 9.13 NOS2 NOS3 SELP
10 arginine catabolic process GO:0006527 8.62 NOS2 NOS3

Molecular functions related to Platelet Membrane Fluidity according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.49 NOS2 NOS3
2 iron ion binding GO:0005506 9.48 NOS2 NOS3
3 heme binding GO:0020037 9.46 NOS2 NOS3
4 flavin adenine dinucleotide binding GO:0050660 9.43 NOS2 NOS3
5 NADP binding GO:0050661 9.4 NOS2 NOS3
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 9.37 NOS2 NOS3
7 FMN binding GO:0010181 9.32 NOS2 NOS3
8 arginine binding GO:0034618 9.26 NOS2 NOS3
9 NADPH-hemoprotein reductase activity GO:0003958 9.16 NOS2 NOS3
10 tetrahydrobiopterin binding GO:0034617 8.96 NOS2 NOS3
11 nitric-oxide synthase activity GO:0004517 8.62 NOS2 NOS3

Sources for Platelet Membrane Fluidity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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