MCID: PLM014
MIFTS: 52

Pleomorphic Adenoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Pleomorphic Adenoma

MalaCards integrated aliases for Pleomorphic Adenoma:

Name: Pleomorphic Adenoma 12 15
Mixed Tumor of the Salivary Gland 12 17
Mixed Tumor, Not Otherwise Specified 71
Mixed Salivary Gland Tumor 71
Adenoma, Pleomorphic 43
Adenoma Pleomorphic 54

Classifications:



External Ids:

Disease Ontology 12 DOID:452
MeSH 43 D008949
NCIt 49 C35691 C8602
SNOMED-CT 67 8360001
UMLS 71 C0026277 C4049618

Summaries for Pleomorphic Adenoma

Disease Ontology : 12 A gastrointestinal system benign neoplasm that is a located in the salivary glands.

MalaCards based summary : Pleomorphic Adenoma, also known as mixed tumor of the salivary gland, is related to salivary gland adenoma, pleomorphic and pleomorphic adenoma carcinoma. An important gene associated with Pleomorphic Adenoma is PLAG1 (PLAG1 Zinc Finger), and among its related pathways/superpathways are Pathways in cancer and Apoptosis Pathway. Affiliated tissues include salivary glands, salivary gland and breast, and related phenotypes are growth/size/body region and cellular

Wikipedia : 74 Pleomorphic adenoma is a common benign salivary gland neoplasm characterised by neoplastic proliferation... more...

Related Diseases for Pleomorphic Adenoma

Diseases related to Pleomorphic Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 472)
# Related Disease Score Top Affiliating Genes
1 salivary gland adenoma, pleomorphic 33.9 S100B PLAG1 HMGA2
2 pleomorphic adenoma carcinoma 33.5 TP53 PLAG1 MAML2 HMGA2 ERBB2 CRTC1
3 adenoma 32.8 TP53 PLAGL2 PLAGL1 PLAG1 MUC1
4 parotid gland cancer 31.2 TP53 ERBB2
5 fasciitis 30.9 VIM TP53 GFAP ACTC1
6 lipomatosis, multiple 30.9 PLAG1 MDM2 HMGA2
7 neurilemmoma 30.9 VIM S100B S100A1 MUC1 GFAP ACTC1
8 adenocarcinoma 30.8 TP53 MUC1 MDM2 HRAS ERBB2
9 leiomyoma 30.8 VIM S100A1 HMGA2 ACTC1
10 squamous cell papilloma 30.8 TP53 KRT14 HRAS
11 pleomorphic lipoma 30.8 MDM2 HMGA2
12 giant cell tumor 30.7 VIM S100B MUC1 ACTC1
13 in situ carcinoma 30.7 TP53 MUC1 KRT14 HRAS ERBB2
14 nodular hidradenoma 30.7 VIM MUC1
15 mammary paget's disease 30.7 MUC1 KRT14 ERBB2
16 lipoadenoma 30.7 MUC1 KRT14 CRTC1
17 oncocytoma 30.6 VIM S100A1 MUC1 KRT14
18 carcinosarcoma 30.6 VIM TP53 S100A1 MUC1 HRAS ERBB2
19 comedo carcinoma 30.6 TP53 KRT14 ERBB2
20 chondroid lipoma 30.5 PLAG1 HMGA2
21 spindle cell carcinoma 30.5 VIM MUC1 KRT14 HRAS ACTC1
22 epithelial-myoepithelial carcinoma 30.5 VIM TP53 PLAG1 MUC1 KRT14 HRAS
23 breast fibroadenoma 30.5 TP53 KRT14 HMGA2 ERBB2 AR
24 mucoepidermoid carcinoma 30.5 TP53 S100A1 MUC1 MAML2 KRT14 ERBB2
25 liposarcoma 30.5 VIM TP53 MDM2 HMGA2
26 chordoma 30.5 VIM TP53 S100B S100A1 MUC1 GFAP
27 meningioma, radiation-induced 30.4 VIM S100B MUC1 GFAP
28 chondroma 30.4 S100A1 HMGA2 ACTC1
29 mucinous adenocarcinoma 30.4 VIM TP53 MUC1 ERBB2
30 hidradenoma 30.4 VIM MUC1 MAML2 CRTC1
31 endometrial adenocarcinoma 30.4 VIM TP53 MUC1 ERBB2
32 rhabdoid tumor predisposition syndrome 1 30.4 VIM TP53 MUC1 ACTC1
33 spindle cell lipoma 30.4 VIM PLAG1 MDM2 ACTC1
34 syringocystadenoma papilliferum 30.4 S100B MUC1 GFAP ACTC1
35 teratoma 30.3 VIM TP53 GFAP ACTC1
36 syringoma 30.3 VIM SERPINB5 S100B S100A1 MUC1 GFAP
37 myoepithelial carcinoma 30.3 VIM TP53 S100A1 PLAG1 MUC1 KRT14
38 cavernous hemangioma 30.3 VIM S100A1 MUC1 KRT14
39 fibroma 30.3 VIM S100A1 KRT14 ACTC1
40 lipoblastoma 30.2 PLAG1 MDM2
41 colorectal adenocarcinoma 30.2 TP53 MUC1 HRAS ERBB2
42 breast metaplastic carcinoma 30.1 MAML2 KRT14 ERBB2 CRTC1
43 submandibular gland cancer 30.1 ERBB2 AR
44 glomus tumor 30.1 VIM TP53 S100A1 MUC1 ACTC1
45 salivary gland carcinoma 30.1 TP53 PLAG1 MDM2 MAML2 ERBB2 CRTC1
46 myoepithelioma 30.1 VIM SERPINB5 S100B S100A1 PLAG1 MUC1
47 myxoid liposarcoma 30.1 TP53 PLAG1 MDM2 HMGA2
48 small cell carcinoma 30.0 TP53 MUC1 AR
49 spindle cell sarcoma 30.0 VIM S100B MUC1 MDM2 ACTC1
50 intraductal papilloma 30.0 MYH11 KRT14 ERBB2

Graphical network of the top 20 diseases related to Pleomorphic Adenoma:



Diseases related to Pleomorphic Adenoma

Symptoms & Phenotypes for Pleomorphic Adenoma

MGI Mouse Phenotypes related to Pleomorphic Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.25 ACTC1 AR CRTC1 ERBB2 GFAP HRAS
2 cellular MP:0005384 10.23 ACTC1 AR ERBB2 GFAP KRT14 MDM2
3 cardiovascular system MP:0005385 10.22 ACTC1 AR ERBB2 GFAP HRAS MDM2
4 homeostasis/metabolism MP:0005376 10.21 ACTC1 AR CRTC1 ERBB2 GFAP HRAS
5 digestive/alimentary MP:0005381 10.09 AR ERBB2 GFAP HRAS KRT14 MDM2
6 mortality/aging MP:0010768 10.07 ACTC1 AR ERBB2 GFAP HRAS KRT14
7 integument MP:0010771 9.97 AR ERBB2 HRAS KRT14 MDM2 MYH11
8 muscle MP:0005369 9.81 ACTC1 AR ERBB2 GFAP MDM2 MYH11
9 normal MP:0002873 9.65 ACTC1 AR ERBB2 GFAP HRAS MDM2
10 respiratory system MP:0005388 9.23 ERBB2 HRAS KRT14 MYH11 PLAGL1 S100A1

Drugs & Therapeutics for Pleomorphic Adenoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Quadrant Parotidectomy Versus Superficial Parotidectomy for Treatment of Pleomorphic Adenoma Withdrawn NCT01607866 Phase 2, Phase 3
2 Phase II Trial of Postoperative Radiotherapy and Panitumumab in High-risk Salivary Gland Malignancies Withdrawn NCT00984217 Phase 2 Panitumumab
3 Use of Multiparametric Magnetic Resonance Imaging in the Management of Head and Neck Cancer: a Prospective Analysis Recruiting NCT03993665
4 Accuracy of Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology in the Preoperative Work-Up of Parotid Gland Neoplasms Recruiting NCT03849482
5 Use of Multiparametric Magnetic Resonance Imaging in the Management of Head and Neck Cancer Active, not recruiting NCT03991533
6 ROLE OF Gray Scale and Doppler Ultrasound in Diagnosis of Parotid and Submandibular Gland Diseases Not yet recruiting NCT03746730

Search NIH Clinical Center for Pleomorphic Adenoma

Cochrane evidence based reviews: adenoma, pleomorphic

Genetic Tests for Pleomorphic Adenoma

Anatomical Context for Pleomorphic Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Pleomorphic Adenoma:

19
Salivary Glands

MalaCards organs/tissues related to Pleomorphic Adenoma:

40
Salivary Gland, Breast, Lung, Trachea, Bone, Tongue, Skin

Publications for Pleomorphic Adenoma

Articles related to Pleomorphic Adenoma:

(show top 50) (show all 3591)
# Title Authors PMID Year
1
[Ezrin and inducible nitric oxide synthase in malignant proliferation of salivary gland pleomorphic adenoma]. 54 61
19799816 2009
2
Glial fibrillary acidic protein in tumor types with cartilaginous differentiation. 54 61
19668151 2009
3
[2009 update in salivary gland tumoral pathology]. 54 61
19900633 2009
4
PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. 54 61
19574421 2009
5
Study of the genetic variability of ZAC1 (PLAGL1) in French population-based samples. 54 61
19155788 2009
6
Expressions of androgen receptor and its co-regulators in carcinoma ex pleomorphic adenoma of salivary gland. 54 61
19672785 2009
7
Immunohistochemical evaluation of androgen receptor, HER-2/neu, and p53 in benign pleomorphic adenomas. 54 61
19061288 2008
8
Heterogeneous genetic profiles in soft tissue myoepitheliomas. 54 61
18604193 2008
9
Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation. 54 61
18655774 2008
10
Loss of Maspin expression is a negative prognostic factor in common salivary gland tumors. 54 61
17936671 2008
11
Upregulation of Igf and Wnt signalling associated genes in pleomorphic adenomas of the salivary glands in PLAG1 transgenic mice. 54 61
18425330 2008
12
Immunohistochemical expression of androgen receptor in salivary gland cancers. 54 61
19391487 2008
13
Dysregulation of Wnt pathway components in human salivary gland tumors. 54 61
18209144 2008
14
PLAGL2 translocation and SP-C promoter activity--a cellular response of lung cells to hypoxia. 54 61
17618602 2007
15
Advances in salivary gland pathology. 54 61
17539914 2007
16
MicroRNA expression profiles in head and neck cancer cell lines. 54 61
17475218 2007
17
WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors. 54 61
17171686 2007
18
Tenascin and fibronectin in pleomorphic adenoma of the salivary gland. 54 61
19089073 2006
19
Application of two different clones of vimentin to the diagnosis of salivary gland tumors. 54 61
16785793 2006
20
Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice. 54 61
16108035 2006
21
Maspin expression in carcinoma ex pleomorphic adenoma. 54 61
16311353 2005
22
Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2. 54 61
16207715 2005
23
Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation. 54 61
16273189 2005
24
p63 expression in salivary gland tumors: role of DeltaNp73L in neoplastic transformation. 54 61
16273188 2005
25
PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry. 54 61
15920557 2005
26
Non-invasive (intracapsular) carcinoma ex pleomorphic adenoma: recognition of focal carcinoma by HER-2/neu and MIB1 immunohistochemistry. 54 61
15693886 2005
27
Expression and localization of cartilage-specific matrix protein chondromodulin-I mRNA in salivary pleomorphic adenomas. 54 61
15549376 2005
28
Pleomorphic adenoma (benign mixed tumor) of the breast: a case report and review of the literature. 54 61
15991841 2005
29
PCNA, Ki-67 and p53 expressions in submandibular salivary gland tumours. 54 61
15308260 2004
30
Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation. 54 61
15208321 2004
31
Maspin expression in normal and neoplastic salivary gland. 54 61
15250837 2004
32
A study of the extracellular matrix in salivary gland tumors. 54 61
12694353 2003
33
Expression of HER-2/neu gene and protein in salivary duct carcinomas of parotid gland as revealed by fluorescence in-situ hybridization and immunohistochemistry. 54 61
12653946 2003
34
Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. 54 61
12406304 2002
35
Pleomorphic adenoma in nasal cavity: immunohistochemical study of three cases. 54 61
12167454 2002
36
Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma. 54 61
11839563 2002
37
Salivary duct carcinoma: cytologic characteristics and application of androgen receptor immunostaining for diagnosis. 54 61
11668470 2001
38
Histologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells. 54 61
11555676 2001
39
Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis. 54 61
11290564 2001
40
Immunolocalisation of cartilage-derived retinoic acid-sensitive protein in pleomorphic adenoma of the parotid salivary gland. 54 61
11168852 2001
41
Expression of E-cadherin, cellular differentiation and polarity in epithelial salivary neoplasms. 54 61
11036244 2000
42
Application of immunohistochemistry to the diagnosis of salivary gland tumors. 54 61
10981871 2000
43
Are myoepithelial cells responsible for the widespread expression of inducible nitric oxide synthase in pleomorphic adenoma? An immunohistochemical study. 54 61
10890559 2000
44
Locus-specific multifluor FISH analysis allows physical characterization of complex chromosome abnormalities in neoplasia. 54 61
10862042 2000
45
[Expression of S-100 proteins and intermediate filament proteins in pleomorphic adenoma]. 54 61
11780221 2000
46
[The expression and mechanism study of BMP in pleomorphic adenoma]. 54 61
12539338 2000
47
PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. 54 61
10646861 2000
48
The myoepithelial immunophenotype in 135 benign and malignant salivary gland tumors other than pleomorphic adenoma. 54 61
10458827 1999
49
Pleomorphic adenoma gene 1 is expressed in cultured benign and malignant salivary gland tumor cells. 54 61
10334569 1999
50
Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. 54 61
10029085 1999

Variations for Pleomorphic Adenoma

Cosmic variations for Pleomorphic Adenoma:

9 (show top 50) (show all 156)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87899124 TP53 salivary gland,parotid,adenoma,pleomorphic c.488A>G p.Y163C 17:7675124-7675124 16
2 COSM87898578 TP53 salivary gland,parotid,adenoma,myoepithelial c.733G>A p.G245S 17:7674230-7674230 16
3 COSM87922154 TP53 salivary gland,parotid,adenoma,pleomorphic c.817C>A p.R273S 17:7673803-7673803 16
4 COSM87913576 TP53 salivary gland,parotid,adenoma,myoepithelial c.536A>T p.H179L 17:7675076-7675076 16
5 COSM122746720 salivary gland,parotid,adenoma,myoepithelial c.140A>T p.H47L 17:7675076-7675076 16
6 COSM144087548 salivary gland,parotid,adenoma,pleomorphic c.11A>G p.Y4C 17:7675124-7675124 16
7 COSM105643083 salivary gland,parotid,adenoma,pleomorphic c.782+378C>A p.? 17:7673803-7673803 16
8 COSM93204208 salivary gland,parotid,adenoma,pleomorphic c.817C>A p.R273S 17:7673803-7673803 16
9 COSM142560924 salivary gland,parotid,adenoma,pleomorphic c.371A>G p.Y124C 17:7675124-7675124 16
10 COSM143173580 salivary gland,parotid,adenoma,pleomorphic c.340C>A p.R114S 17:7673803-7673803 16
11 COSM142852695 salivary gland,parotid,adenoma,pleomorphic c.817C>A p.R273S 17:7673803-7673803 16
12 COSM144310364 salivary gland,parotid,adenoma,myoepithelial c.616G>A p.G206S 17:7674230-7674230 16
13 COSM105634286 salivary gland,parotid,adenoma,myoepithelial c.536A>T p.H179L 17:7675076-7675076 16
14 COSM144310842 salivary gland,parotid,adenoma,pleomorphic c.371A>G p.Y124C 17:7675124-7675124 16
15 COSM106066097 salivary gland,parotid,adenoma,myoepithelial c.536A>T p.H179L 17:7675076-7675076 16
16 COSM93197065 salivary gland,parotid,adenoma,myoepithelial c.536A>T p.H179L 17:7675076-7675076 16
17 COSM122271749 salivary gland,parotid,adenoma,myoepithelial c.337G>A p.G113S 17:7674230-7674230 16
18 COSM111779193 salivary gland,parotid,adenoma,pleomorphic c.817C>A p.R273S 17:7673803-7673803 16
19 COSM143391770 salivary gland,parotid,adenoma,pleomorphic c.700C>A p.R234S 17:7673803-7673803 16
20 COSM145036443 salivary gland,parotid,adenoma,pleomorphic c.700C>A p.R234S 17:7673803-7673803 16
21 COSM112254313 salivary gland,parotid,adenoma,pleomorphic c.488A>G p.Y163C 17:7675124-7675124 16
22 COSM142837877 salivary gland,parotid,adenoma,pleomorphic c.488A>G p.Y163C 17:7675124-7675124 16
23 COSM93183877 salivary gland,parotid,adenoma,myoepithelial c.733G>A p.G245S 17:7674230-7674230 16
24 COSM105620519 salivary gland,parotid,adenoma,myoepithelial c.733G>A p.G245S 17:7674230-7674230 16
25 COSM144013587 salivary gland,parotid,adenoma,myoepithelial c.700G>A p.G234S 17:7674230-7674230 16
26 COSM145030355 salivary gland,parotid,adenoma,myoepithelial c.419A>T p.H140L 17:7675076-7675076 16
27 COSM144031768 salivary gland,parotid,adenoma,pleomorphic c.784C>A p.R262S 17:7673803-7673803 16
28 COSM122734714 salivary gland,parotid,adenoma,pleomorphic c.92A>G p.Y31C 17:7675124-7675124 16
29 COSM105621094 salivary gland,parotid,adenoma,pleomorphic c.488A>G p.Y163C 17:7675124-7675124 16
30 COSM144025757 salivary gland,parotid,adenoma,myoepithelial c.503A>T p.H168L 17:7675076-7675076 16
31 COSM111772864 salivary gland,parotid,adenoma,myoepithelial c.536A>T p.H179L 17:7675076-7675076 16
32 COSM112274404 salivary gland,parotid,adenoma,pleomorphic c.817C>A p.R273S 17:7673803-7673803 16
33 COSM143371076 salivary gland,parotid,adenoma,myoepithelial c.616G>A p.G206S 17:7674230-7674230 16
34 COSM111759267 salivary gland,parotid,adenoma,pleomorphic c.488A>G p.Y163C 17:7675124-7675124 16
35 COSM121890949 salivary gland,parotid,adenoma,myoepithelial c.140A>T p.H47L 17:7675076-7675076 16
36 COSM93184440 salivary gland,parotid,adenoma,pleomorphic c.488A>G p.Y163C 17:7675124-7675124 16
37 COSM112266394 salivary gland,parotid,adenoma,myoepithelial c.536A>T p.H179L 17:7675076-7675076 16
38 COSM143371571 salivary gland,parotid,adenoma,pleomorphic c.371A>G p.Y124C 17:7675124-7675124 16
39 COSM143944574 salivary gland,parotid,adenoma,pleomorphic c.11A>G p.Y4C 17:7675124-7675124 16
40 COSM144651907 salivary gland,parotid,adenoma,pleomorphic c.371A>G p.Y124C 17:7675124-7675124 16
41 COSM144321021 salivary gland,parotid,adenoma,myoepithelial c.419A>T p.H140L 17:7675076-7675076 16
42 COSM142580266 salivary gland,parotid,adenoma,pleomorphic c.700C>A p.R234S 17:7673803-7673803 16
43 COSM106053828 salivary gland,parotid,adenoma,pleomorphic c.488A>G p.Y163C 17:7675124-7675124 16
44 COSM122734335 salivary gland,parotid,adenoma,myoepithelial c.337G>A p.G113S 17:7674230-7674230 16
45 COSM143943997 salivary gland,parotid,adenoma,myoepithelial c.256G>A p.G86S 17:7674230-7674230 16
46 COSM142837497 salivary gland,parotid,adenoma,myoepithelial c.733G>A p.G245S 17:7674230-7674230 16
47 COSM144666203 salivary gland,parotid,adenoma,myoepithelial c.419A>T p.H140L 17:7675076-7675076 16
48 COSM122272158 salivary gland,parotid,adenoma,pleomorphic c.92A>G p.Y31C 17:7675124-7675124 16
49 COSM143156960 salivary gland,parotid,adenoma,myoepithelial c.256G>A p.G86S 17:7674230-7674230 16
50 COSM106072773 salivary gland,parotid,adenoma,pleomorphic c.817C>A p.R273S 17:7673803-7673803 16

Copy number variations for Pleomorphic Adenoma from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 239266 8 38279166 38315052 Gain FGFR1 Pleomorphic adenoma

Expression for Pleomorphic Adenoma

Search GEO for disease gene expression data for Pleomorphic Adenoma.

Pathways for Pleomorphic Adenoma

Pathways related to Pleomorphic Adenoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1 12.65 TP53 MDM2 HRAS ERBB2 AR
2
Show member pathways
12.26 TP53 MDM2 HRAS ERBB2
3
Show member pathways
12.15 TP53 MUC1 MDM2 HRAS ERBB2
4 12.01 TP53 MDM2 HRAS ERBB2
5
Show member pathways
11.83 MDM2 HRAS ERBB2 AR
6 11.68 TP53 MDM2 HRAS ERBB2
7 11.66 VIM TP53 SERPINB5 MDM2 HRAS HMGA2
8 11.6 TP53 MDM2 KRT14
9 11.57 VIM S100B GFAP
10 11.52 TP53 MDM2 ERBB2
11 11.47 TP53 HRAS ERBB2
12 11.43 TP53 HRAS ERBB2
13
Show member pathways
11.39 S100B MDM2 HRAS GFAP ERBB2
14 11.32 TP53 MDM2 HRAS ERBB2

GO Terms for Pleomorphic Adenoma

Cellular components related to Pleomorphic Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10 VIM TP53 SERPINB5 S100B S100A1 MUC1
2 cytosol GO:0005829 9.77 VIM TP53 S100B PLAG1 MYH11 MDM2
3 nucleus GO:0005634 9.53 VIM TP53 S100B S100A1 PLAGL2 PLAGL1

Biological processes related to Pleomorphic Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism growth GO:0035264 9.69 TP53 PLAG1 AR
2 negative regulation of neuron projection development GO:0010977 9.67 VIM MDM2 GFAP
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.61 TP53 PLAGL2 PLAGL1 PLAG1 MAML2 HRAS
4 Bergmann glial cell differentiation GO:0060020 9.48 VIM GFAP
5 cellular response to UV-C GO:0071494 9.46 TP53 MDM2
6 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.46 TP53 PLAGL1 MUC1 MDM2
7 prostate gland growth GO:0060736 9.43 PLAG1 AR
8 cellular response to gamma radiation GO:0071480 9.43 TP53 MDM2 HRAS
9 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.4 TP53 MUC1
10 cellular response to actinomycin D GO:0072717 9.37 TP53 MDM2
11 intermediate filament-based process GO:0045103 9.32 VIM GFAP
12 positive regulation of gene expression GO:0010628 9.28 VIM TP53 PLAG1 MDM2 HRAS HMGA2

Molecular functions related to Pleomorphic Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.72 TP53 PLAG1 MUC1 HMGA2 AR
2 identical protein binding GO:0042802 9.7 VIM TP53 S100B S100A1 MDM2 GFAP
3 p53 binding GO:0002039 9.43 TP53 MUC1 MDM2
4 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.1 TP53 PLAGL2 PLAGL1 PLAG1 HMGA2 AR
5 keratin filament binding GO:1990254 8.96 VIM KRT14

Sources for Pleomorphic Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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