MCID: PLM009
MIFTS: 32

Pleomorphic Adenoma Carcinoma

Categories: Oral diseases, Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Pleomorphic Adenoma Carcinoma

MalaCards integrated aliases for Pleomorphic Adenoma Carcinoma:

Name: Pleomorphic Adenoma Carcinoma 12 15
Carcinoma Ex Pleomorphic Adenoma 12 73
Carcinoma in Pleomorphic Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:297
NCIt 50 C4397
SNOMED-CT 68 17264009 189811003
UMLS 73 C0344460

Summaries for Pleomorphic Adenoma Carcinoma

MalaCards based summary : Pleomorphic Adenoma Carcinoma, also known as carcinoma ex pleomorphic adenoma, is related to mixed lacrimal gland cancer and gallbladder squamous cell carcinoma. An important gene associated with Pleomorphic Adenoma Carcinoma is DENR (Density Regulated Re-Initiation And Release Factor), and among its related pathways/superpathways is AKT Signaling Pathway. Affiliated tissues include salivary gland, tongue and lung, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Pleomorphic Adenoma Carcinoma

Diseases related to Pleomorphic Adenoma Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 mixed lacrimal gland cancer 11.8
2 gallbladder squamous cell carcinoma 10.7 ERBB2 TP53
3 gastric papillary adenocarcinoma 10.7 ERBB2 TP53
4 uterine corpus serous adenocarcinoma 10.7 ERBB2 TP53
5 non-proliferative fibrocystic change of the breast 10.7 ERBB2 TP53
6 fallopian tube adenocarcinoma 10.7 ERBB2 TP53
7 uterine body mixed cancer 10.7 ERBB2 TP53
8 glioma susceptibility 1 10.7 ERBB2 TP53
9 oral leukoplakia 10.7 ERBB2 TP53
10 microglandular adenosis 10.7 ERBB2 TP53
11 uterine corpus cancer 10.7 ERBB2 TP53
12 breast benign neoplasm 10.7 ERBB2 TP53
13 thoracic benign neoplasm 10.7 ERBB2 TP53
14 esophagus adenocarcinoma 10.7 ERBB2 TP53
15 ovary adenocarcinoma 10.7 ERBB2 TP53
16 hidradenocarcinoma 10.6 ERBB2 TP53
17 primary peritoneal carcinoma 10.6 ERBB2 TP53
18 atypical follicular adenoma 10.6 ENO2 TP53
19 central nervous system primitive neuroectodermal neoplasm 10.6 ENO2 TP53
20 cerebellum cancer 10.6 ENO2 TP53
21 cerebral neuroblastoma 10.6 ENO2 TP53
22 cerebral ventricle cancer 10.6 ENO2 TP53
23 pre-malignant neoplasm 10.6 ERBB2 TP53
24 cerebrum cancer 10.6 ENO2 TP53
25 liver sarcoma 10.6 LYZ PTHLH
26 granulomatous myositis 10.6 LYZ PTHLH
27 ulcerative stomatitis 10.6 LYZ TP53
28 fallopian tube carcinoma 10.6 ERBB2 TP53
29 supratentorial cancer 10.6 ENO2 TP53
30 papillary adenocarcinoma 10.6 ERBB2 TP53
31 meningeal melanomatosis 10.5 ENO2 TP53
32 keratocystic odontogenic tumor 10.5 PTHLH TP53
33 glomus tumor 10.5 ENO2 TP53
34 cervix small cell carcinoma 10.5 ENO2 TP53
35 cystic teratoma 10.5 ENO2 TP53
36 xanthogranulomatous cholecystitis 10.5 LYZ TP53
37 basaloid squamous cell carcinoma 10.5 ENO2 TP53
38 barrett's adenocarcinoma 10.5 ERBB2 TP53
39 cerebellar liponeurocytoma 10.5 ENO2 TP53
40 cerebral primitive neuroectodermal tumor 10.5 ENO2 TP53
41 liver angiosarcoma 10.5 ENO2 TP53
42 optic nerve neoplasm 10.5 ENO2 TP53
43 adenosquamous cell lung carcinoma 10.5 ENO2 ERBB2
44 congenital granular cell tumor 10.5 ENO2 LYZ
45 angiomyoma 10.5 ENO2 PTHLH
46 auditory system cancer 10.5 ENO2 LYZ
47 sweat gland cancer 10.5 ERBB2 TP53
48 medullomyoblastoma 10.5 ENO2 TP53
49 paraneoplastic cerebellar degeneration 10.4 ENO2 ERBB2
50 bladder squamous cell carcinoma 10.4 ERBB2 TP53

Graphical network of the top 20 diseases related to Pleomorphic Adenoma Carcinoma:



Diseases related to Pleomorphic Adenoma Carcinoma

Symptoms & Phenotypes for Pleomorphic Adenoma Carcinoma

MGI Mouse Phenotypes related to Pleomorphic Adenoma Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 BECN1 ENO2 ERBB2 LYZ PTHLH STAC3
2 cardiovascular system MP:0005385 9.91 BECN1 ERBB2 LYZ PTHLH STAC3 TP53
3 nervous system MP:0003631 9.76 BECN1 ENO2 ERBB2 LYZ PTHLH STAC3
4 integument MP:0010771 9.73 LYZ PTHLH STAC3 TP53 BECN1 ERBB2
5 craniofacial MP:0005382 9.72 ENO2 ERBB2 PTHLH STAC3 TP53
6 respiratory system MP:0005388 9.43 ENO2 ERBB2 LYZ PTHLH STAC3 TP53
7 skeleton MP:0005390 9.1 DENR ERBB2 LYZ PTHLH STAC3 TP53

Drugs & Therapeutics for Pleomorphic Adenoma Carcinoma

Search Clinical Trials , NIH Clinical Center for Pleomorphic Adenoma Carcinoma

Genetic Tests for Pleomorphic Adenoma Carcinoma

Anatomical Context for Pleomorphic Adenoma Carcinoma

MalaCards organs/tissues related to Pleomorphic Adenoma Carcinoma:

41
Salivary Gland, Tongue, Lung

Publications for Pleomorphic Adenoma Carcinoma

Articles related to Pleomorphic Adenoma Carcinoma:

(show top 50) (show all 145)
# Title Authors Year
1
Primary carcinoma ex-pleomorphic adenoma of anterior commissure of the larynx. ( 29980410 )
2018
2
Cripto-1 is overexpressed in carcinoma ex pleomorphic adenoma of salivary gland. ( 29594385 )
2018
3
Promoter hypermethylation may contribute to Ea89cadherin repression in the human salivary carcinoma ex pleomorphic adenoma. ( 29207084 )
2018
4
Dedifferentiated adenoid cystic carcinoma ex pleomorphic adenoma of the parotid. ( 29893347 )
2018
5
Recurrent rearrangements of the PLAG1 and HMGA2 genes in lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma. ( 29437290 )
2018
6
Gray scale and doppler ultrasonography features of the carcinoma ex pleomorphic adenoma. ( 29365290 )
2018
7
Intracapsular carcinoma ex-pleomorphic adenoma of the parapharyngeal space: report of two cases and review of the literature. ( 29143959 )
2017
8
Increased SOX2 expression in salivary gland carcinoma ex pleomorphic adenoma progression: an association with adverse outcome. ( 28842747 )
2017
9
BRCA1/2 Mutations in Salivary Pleomorphic Adenoma and Carcinoma-ex-Pleomorphic Adenoma. ( 29285471 )
2017
10
A Case Report of Rare Carcinoma Ex Pleomorphic Adenoma of Submandibular Gland and its Detailed Description. ( 28658924 )
2017
11
Low Grade Carcinoma Ex-Pleomorphic Adenoma: Diagnosis and Diagnostic Challenges Caused by Fine Needle Aspiration: Report of Three Cases and Review of Literature. ( 28589437 )
2017
12
Carcinoma ex pleomorphic adenoma: case report and options for systemic therapy. ( 28680294 )
2017
13
Prognostic nomogram for disease-specific survival of carcinoma ex pleomorphic adenoma of the salivary gland. ( 28945292 )
2017
14
Loss Expression of Plag1 in Malignant Transformation from Pleomorphic Adenoma to Carcinoma Ex-Pleomorphic Adenoma. ( 27473265 )
2016
15
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland with Epithelial-Myoepithelial Carcinoma Histologic Type. ( 26934566 )
2016
16
Pedunculated carcinoma ex pleomorphic adenoma of the nasal cavity: A unique case report. ( 27684860 )
2016
17
Carcinoma Ex Pleomorphic Adenoma: Is It a High-Grade Malignancy? ( 27131030 )
2016
18
Rare Carcinoma Ex-pleomorphic Adenoma of Buccal Mucosa: Case Report and Review of Literature. ( 27134712 )
2016
19
Carcinoma Ex Pleomorphic Adenoma of the Tongue: Difficulty in Diagnosis Between Metastasis of Breast Cancer and Salivary Tumor. ( 27755404 )
2016
20
A low percentage of HER-2 amplification whereas indicates poor prognosis in salivary carcinoma ex pleomorphic adenoma: a study of 140 cases. ( 27423271 )
2016
21
Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports. ( 27793123 )
2016
22
Thoracic intramedullary spinal metastasis from carcinoma ex pleomorphic adenoma of the submandibular gland. ( 27841228 )
2016
23
Genomic profile of a squamous cell carcinoma ex pleomorphic adenoma compared to a head and neck squamous cell carcinoma. ( 26971044 )
2016
24
Prognostic factors of carcinoma ex pleomorphic adenoma of the salivary glands, with emphasis on the widely invasive carcinoma: a clinicopathologic analysis of 361 cases in a Chinese population. ( 27546212 )
2016
25
Evaluation of a subset of tumor suppressor gene for copy number and epigenitic changes in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma carcinogenesis. ( 27544395 )
2016
26
Combined salivary duct carcinoma and squamous cell carcinoma suspected of carcinoma ex pleomorphic adenoma. ( 27435055 )
2016
27
Incidentally Detected Carcinoma Ex Pleomorphic Adenoma of Parotid Gland by F-18 FDG PET/CT. ( 26941868 )
2016
28
Carcinoma ex-pleomorphic adenoma derived from recurrent pleomorphic adenoma shows important difference by array CGH compared to recurrent pleomorphic adenoma without malignant transformation. ( 26971045 )
2016
29
A rare carcinoma ex pleomorphic adenoma of the buccal minor salivary gland causing a therapeutic dilemma. ( 27146731 )
2016
30
Dual gain of HER2 and EGFR gene copy numbers impacts the prognosis of carcinoma ex pleomorphic adenoma. ( 26345124 )
2015
31
Consistent PLAG1 and HMGA2 abnormalities distinguish carcinoma ex-pleomorphic adenoma from its de novo counterparts. ( 25439740 )
2015
32
Cellular senescence and autophagy of myoepithelial cells are involved in the progression of in situ areas of carcinoma ex-pleomorphic adenoma to invasive carcinoma. An in vitro model. ( 25895748 )
2015
33
Cellular Proliferation Index between Carcinoma Ex-Pleomorphic Adenoma and Pleomorphic Adenoma. ( 26312983 )
2015
34
Salivary duct carcinoma ex pleomorphic adenoma of the palate: a case report. ( 25579019 )
2015
35
Carcinoma ex pleomorphic adenoma of minor salivary glands with major epithelial-myoepithelial component: clinicopathologic and immunohistochemical study of 3 cases. ( 25890488 )
2015
36
Carcinoma ex-pleomorphic adenoma of the parotid gland consisting of high-grade salivary duct carcinoma and keratinizing squamous cell carcinoma. ( 25782724 )
2015
37
A Rare Case of Mucoepidermoid Carcinoma ex Pleomorphic Adenoma arising in Minor Salivary Gland: Histopathological and Immunohistochemical Analysis. ( 26329417 )
2015
38
Clear cell myoepithelial carcinoma ex pleomorphic adenoma. ( 25118745 )
2014
39
Carcinoma ex pleomorphic adenoma: Diagnostic dilemma and treatment protocol. ( 25565746 )
2014
40
Carcinoma ex pleomorphic adenoma of the palate composed of invasive micropapillary salivary duct carcinoma and adenoid cystic carcinoma components: an unusual case with immunohistochemical approach. ( 25501054 )
2014
41
Head and Neck Pathology: SY13-3 CARCINOMA EX PLEOMORPHIC ADENOMA. ( 25188085 )
2014
42
Lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma: genomic profiles, gene fusions, and clinical characteristics. ( 24468654 )
2014
43
Lacrimal gland carcinoma ex pleomorphic adenoma with chronic lymphocytic leukemia infiltration. ( 25336906 )
2014
44
Large carcinoma ex pleomorphic adenoma of the parotid gland: a case report and review of literature. ( 24237779 )
2013
45
A case of carcinoma ex pleomorphic adenoma in the buccal mucosa: review of the literature. ( 24431844 )
2013
46
Predictors of survival in carcinoma ex pleomorphic adenoma. ( 23956034 )
2013
47
Assessment of inverse correlation of p16 and pRb expression in carcinoma ex pleomorphic adenoma. ( 23900873 )
2013
48
t(3;8) as the sole chromosomal abnormality in a myoepithelial carcinoma ex pleomorphic adenoma: a putative progression event. ( 22287457 )
2013
49
Carcinoma ex pleomorphic adenoma of the upper lip: a case of an unusual malignant component of squamous cell carcinoma. ( 24044722 )
2013
50
Carcinoma ex-pleomorphic adenoma -- a giant tumor. ( 23618582 )
2013

Variations for Pleomorphic Adenoma Carcinoma

Copy number variations for Pleomorphic Adenoma Carcinoma from CNVD:

7 (show all 12)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 16422 1 124300000 205300000 Amplification Carcinoma ex pleomorphic adenoma
2 37764 1 94500000 107000000 Loss Carcinoma ex pleomorphic adenoma
3 44907 10 64800000 71300000 Loss Carcinoma ex pleomorphic adenoma
4 67036 12 35400000 132349534 Amplification HMGA2 Carcinoma ex pleomorphic adenoma
5 67038 12 35400000 132349534 Amplification MDM2 Carcinoma ex pleomorphic adenoma
6 89426 15 18400000 23300000 Loss Carcinoma ex pleomorphic adenoma
7 112095 17 37856254 37884915 Amplification ERBB2 Carcinoma ex pleomorphic adenoma
8 146803 2 54800000 83700000 Amplification Carcinoma ex pleomorphic adenoma
9 192955 5 121500000 139000000 Loss Carcinoma ex pleomorphic adenoma
10 230836 8 1 45200000 Loss Carcinoma ex pleomorphic adenoma
11 240831 8 55600000 61700000 Amplification PLAG1 Carcinoma ex pleomorphic adenoma
12 241224 8 59800000 127300000 Amplification MYC Carcinoma ex pleomorphic adenoma

Expression for Pleomorphic Adenoma Carcinoma

Search GEO for disease gene expression data for Pleomorphic Adenoma Carcinoma.

Pathways for Pleomorphic Adenoma Carcinoma

Pathways related to Pleomorphic Adenoma Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.95 BECN1 ERBB2 TP53

GO Terms for Pleomorphic Adenoma Carcinoma

Biological processes related to Pleomorphic Adenoma Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to epidermal growth factor stimulus GO:0071364 8.96 BECN1 ERBB2
2 cellular response to glucose starvation GO:0042149 8.62 BECN1 TP53

Sources for Pleomorphic Adenoma Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....