MCID: PLM009
MIFTS: 35

Pleomorphic Adenoma Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pleomorphic Adenoma Carcinoma

MalaCards integrated aliases for Pleomorphic Adenoma Carcinoma:

Name: Pleomorphic Adenoma Carcinoma 12 15
Carcinoma Ex Pleomorphic Adenoma 12 73
Carcinoma in Pleomorphic Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:297
NCIt 50 C4397
SNOMED-CT 68 17264009
UMLS 73 C0344460

Summaries for Pleomorphic Adenoma Carcinoma

MalaCards based summary : Pleomorphic Adenoma Carcinoma, also known as carcinoma ex pleomorphic adenoma, is related to pleomorphic adenoma and mucoepidermoid carcinoma. An important gene associated with Pleomorphic Adenoma Carcinoma is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are MicroRNAs in cancer and Bladder cancer. Affiliated tissues include salivary gland, brain and spleen, and related phenotypes are Decreased CDKN1A mRNA expression and Decreased CDKN1A mRNA expression

Related Diseases for Pleomorphic Adenoma Carcinoma

Diseases related to Pleomorphic Adenoma Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 pleomorphic adenoma 30.6 ERBB2 HMGA2 TP53
2 mucoepidermoid carcinoma 30.5 ERBB2 MAML2
3 epithelial-myoepithelial carcinoma 30.5 HMGA2 TP53
4 mixed cell type cancer 30.2 ERBB2 TP53
5 in situ carcinoma 30.2 ERBB2 TP53
6 mixed lacrimal gland cancer 12.0
7 myoepithelioma 10.5
8 squamous cell carcinoma 10.5
9 adenocarcinoma 10.4
10 adenoid cystic carcinoma 10.3
11 salivary gland adenoma, pleomorphic 10.2
12 adenoma 10.2
13 breast fibroadenoma 10.2 ERBB2 HMGA2
14 scrotal carcinoma 10.1 HMGA2 TP53
15 dedifferentiated liposarcoma 10.1 HMGA2 TP53
16 liposarcoma 10.1 HMGA2 TP53
17 gastric papillary adenocarcinoma 10.1 ERBB2 TP53
18 papillary adenocarcinoma 10.1 ERBB2 TP53
19 non-proliferative fibrocystic change of the breast 10.1 ERBB2 TP53
20 uterine corpus serous adenocarcinoma 10.1 ERBB2 TP53
21 breast squamous cell carcinoma 10.1 ERBB2 TP53
22 uterine body mixed cancer 10.1 ERBB2 TP53
23 glioma susceptibility 1 10.1 ERBB2 TP53
24 microglandular adenosis 10.1 ERBB2 TP53
25 esophagus adenocarcinoma 10.1 ERBB2 TP53
26 breast benign neoplasm 10.1 ERBB2 TP53
27 thoracic benign neoplasm 10.1 ERBB2 TP53
28 uterine corpus cancer 10.1 ERBB2 TP53
29 granulosa cell tumor of the ovary 10.1 ERBB2 TP53
30 hidradenocarcinoma 10.1 ERBB2 TP53
31 primary peritoneal carcinoma 10.1 ERBB2 TP53
32 pre-malignant neoplasm 10.1 ERBB2 TP53
33 atypical teratoid rhabdoid tumor 10.1 HMGA2 TP53
34 fallopian tube carcinoma 10.1 ERBB2 TP53
35 barrett's adenocarcinoma 10.1 ERBB2 TP53
36 ovary adenocarcinoma 10.1 ERBB2 TP53
37 breast carcinoma in situ 10.1 ERBB2 TP53
38 ovarian cancer 1 10.1 ERBB2 TP53
39 malignant ovarian surface epithelial-stromal neoplasm 10.1 ERBB2 TP53
40 lipoadenoma 10.1 HMGA2 MAML2
41 ovary epithelial cancer 10.1 ERBB2 TP53
42 esophageal disease 10.1 ERBB2 TP53
43 female breast cancer 10.1 ERBB2 TP53
44 pharynx cancer 10.1 BPIFB1 TP53
45 serous cystadenocarcinoma 10.1 ERBB2 TP53
46 myxoid liposarcoma 10.1 HMGA2 TP53
47 cystadenocarcinoma 10.1 ERBB2 TP53
48 nasopharyngeal disease 10.1 BPIFB1 TP53
49 cervical adenocarcinoma 10.1 ERBB2 TP53
50 estrogen-receptor positive breast cancer 10.1 ERBB2 TP53

Graphical network of the top 20 diseases related to Pleomorphic Adenoma Carcinoma:



Diseases related to Pleomorphic Adenoma Carcinoma

Symptoms & Phenotypes for Pleomorphic Adenoma Carcinoma

GenomeRNAi Phenotypes related to Pleomorphic Adenoma Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased CDKN1A mRNA expression GR00389-S-1 9.13 TP53
2 Decreased CDKN1A mRNA expression GR00389-S-2 9.13 HMGA2 TP53
3 Increased TP53 mRNA expression GR00389-S-6 8.62 HMGA2 TP53

Drugs & Therapeutics for Pleomorphic Adenoma Carcinoma

Search Clinical Trials , NIH Clinical Center for Pleomorphic Adenoma Carcinoma

Genetic Tests for Pleomorphic Adenoma Carcinoma

Anatomical Context for Pleomorphic Adenoma Carcinoma

MalaCards organs/tissues related to Pleomorphic Adenoma Carcinoma:

41
Salivary Gland, Brain, Spleen, Ovary, Tonsil, Pancreas, B Cells

Publications for Pleomorphic Adenoma Carcinoma

Articles related to Pleomorphic Adenoma Carcinoma:

(show top 50) (show all 195)
# Title Authors Year
1
Primary carcinoma ex-pleomorphic adenoma of anterior commissure of the larynx. ( 29980410 )
2018
2
Cripto-1 is overexpressed in carcinoma ex pleomorphic adenoma of salivary gland. ( 29594385 )
2018
3
Promoter hypermethylation may contribute to Ea89cadherin repression in the human salivary carcinoma ex pleomorphic adenoma. ( 29207084 )
2018
4
Dedifferentiated adenoid cystic carcinoma ex pleomorphic adenoma of the parotid. ( 29893347 )
2018
5
Recurrent rearrangements of the PLAG1 and HMGA2 genes in lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma. ( 29437290 )
2018
6
Gray scale and doppler ultrasonography features of the carcinoma ex pleomorphic adenoma. ( 29365290 )
2018
7
Acantholytic Squamous Cell Carcinoma and Salivary Duct Carcinoma Ex-pleomorphic Adenoma of the Submandibular Gland: A Report of Two Extremely Rare Cases with an Immunohistochemical Analysis. ( 30484070 )
2018
8
Human epithelial growth factor receptor 2 in human salivary carcinoma ex pleomorphic adenoma: a potential therapeutic target. ( 30555262 )
2018
9
CD44 expression in pleomorphic adenoma, carcinoma ex pleomorphic adenoma and their adjacent normal salivary glands. ( 30233657 )
2018
10
Clinicopathological effect of PLAG1 fusion genes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma with special emphasis on histological features. ( 30307055 )
2018
11
Carcinoma Ex Pleomorphic Adenoma Presented as a Gigantic Tumor: Treatment and Diagnostic Challenges. ( 30038735 )
2018
12
Trastuzumab Emtansine for the Treatment of HER-2 Positive Carcinoma Ex-pleomorphic Adenoma Metastatic to the Brain: A Case Report. ( 30087853 )
2018
13
Age and adenoma size are independent risk factors for the development of carcinoma ex pleomorphic adenoma. ( 30115468 )
2018
14
Intracapsular carcinoma ex-pleomorphic adenoma of the parapharyngeal space: report of two cases and review of the literature. ( 29143959 )
2017
15
Increased SOX2 expression in salivary gland carcinoma ex pleomorphic adenoma progression: an association with adverse outcome. ( 28842747 )
2017
16
BRCA1/2 Mutations in Salivary Pleomorphic Adenoma and Carcinoma-ex-Pleomorphic Adenoma. ( 29285471 )
2017
17
A Case Report of Rare Carcinoma Ex Pleomorphic Adenoma of Submandibular Gland and its Detailed Description. ( 28658924 )
2017
18
Low Grade Carcinoma Ex-Pleomorphic Adenoma: Diagnosis and Diagnostic Challenges Caused by Fine Needle Aspiration: Report of Three Cases and Review of Literature. ( 28589437 )
2017
19
Carcinoma ex pleomorphic adenoma: case report and options for systemic therapy. ( 28680294 )
2017
20
Prognostic nomogram for disease-specific survival of carcinoma ex pleomorphic adenoma of the salivary gland. ( 28945292 )
2017
21
Absence of myoepithelial cells correlates with invasion and metastasis of Carcinoma ex pleomorphic adenoma. ( 28431798 )
2017
22
HMGA2 is a specific immunohistochemical marker for pleomorphic adenoma and carcinoma ex-pleomorphic adenoma. ( 28463429 )
2017
23
Brain metastasis of carcinoma ex pleomorphic adenoma of the parotid gland: case report and review of the literature. ( 28108853 )
2017
24
Carcinoma ex pleomorphic adenoma: A diagnostic challenge on cytology. ( 28261993 )
2017
25
Histological, immunohistological and molecular characteristics of intraductal precursor of carcinoma ex pleomorphic adenoma support a multistep carcinogenic process. ( 28353089 )
2017
26
Loss Expression of Plag1 in Malignant Transformation from Pleomorphic Adenoma to Carcinoma Ex-Pleomorphic Adenoma. ( 27473265 )
2016
27
Carcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland with Epithelial-Myoepithelial Carcinoma Histologic Type. ( 26934566 )
2016
28
Pedunculated carcinoma ex pleomorphic adenoma of the nasal cavity: A unique case report. ( 27684860 )
2016
29
Carcinoma Ex Pleomorphic Adenoma: Is It a High-Grade Malignancy? ( 27131030 )
2016
30
Rare Carcinoma Ex-pleomorphic Adenoma of Buccal Mucosa: Case Report and Review of Literature. ( 27134712 )
2016
31
Carcinoma Ex Pleomorphic Adenoma of the Tongue: Difficulty in Diagnosis Between Metastasis of Breast Cancer and Salivary Tumor. ( 27755404 )
2016
32
A low percentage of HER-2 amplification whereas indicates poor prognosis in salivary carcinoma ex pleomorphic adenoma: a study of 140 cases. ( 27423271 )
2016
33
Invasive myoepithelial carcinoma ex pleomorphic adenoma of the major salivary gland: two case reports. ( 27793123 )
2016
34
Thoracic intramedullary spinal metastasis from carcinoma ex pleomorphic adenoma of the submandibular gland. ( 27841228 )
2016
35
Genomic profile of a squamous cell carcinoma ex pleomorphic adenoma compared to a head and neck squamous cell carcinoma. ( 26971044 )
2016
36
Prognostic factors of carcinoma ex pleomorphic adenoma of the salivary glands, with emphasis on the widely invasive carcinoma: a clinicopathologic analysis of 361 cases in a Chinese population. ( 27546212 )
2016
37
Evaluation of a subset of tumor suppressor gene for copy number and epigenitic changes in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma carcinogenesis. ( 27544395 )
2016
38
Combined salivary duct carcinoma and squamous cell carcinoma suspected of carcinoma ex pleomorphic adenoma. ( 27435055 )
2016
39
Incidentally Detected Carcinoma Ex Pleomorphic Adenoma of Parotid Gland by F-18 FDG PET/CT. ( 26941868 )
2016
40
Carcinoma ex-pleomorphic adenoma derived from recurrent pleomorphic adenoma shows important difference by array CGH compared to recurrent pleomorphic adenoma without malignant transformation. ( 26971045 )
2016
41
Carcinoma ex-pleomorphic adenoma of the salivary glands has a high risk of progression when the tumor invades more than 2.5 mm beyond the capsule of the residual pleomorphic adenoma. ( 26638158 )
2016
42
A rare carcinoma ex pleomorphic adenoma of the buccal minor salivary gland causing a therapeutic dilemma. ( 27146731 )
2016
43
The interleukin-6/Janus kinase/STAT3 pathway in pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the lacrimal gland. ( 27286739 )
2016
44
Carcinoma ex pleomorphic adenoma of the parotid gland: a multi-institutional retrospective analysis in the Northern Japan Head and Neck Cancer Society. ( 27295405 )
2016
45
Pineal and leptomeningeal metastases from a parotid carcinoma ex pleomorphic adenoma. ( 30364445 )
2016
46
Dual gain of HER2 and EGFR gene copy numbers impacts the prognosis of carcinoma ex pleomorphic adenoma. ( 26345124 )
2015
47
Consistent PLAG1 and HMGA2 abnormalities distinguish carcinoma ex-pleomorphic adenoma from its de novo counterparts. ( 25439740 )
2015
48
Cellular senescence and autophagy of myoepithelial cells are involved in the progression of in situ areas of carcinoma ex-pleomorphic adenoma to invasive carcinoma. An in vitro model. ( 25895748 )
2015
49
Cellular Proliferation Index between Carcinoma Ex-Pleomorphic Adenoma and Pleomorphic Adenoma. ( 26312983 )
2015
50
Salivary duct carcinoma ex pleomorphic adenoma of the palate: a case report. ( 25579019 )
2015

Variations for Pleomorphic Adenoma Carcinoma

Copy number variations for Pleomorphic Adenoma Carcinoma from CNVD:

7 (show all 12)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 16422 1 124300000 205300000 Amplification Carcinoma ex pleomorphic adenoma
2 37764 1 94500000 107000000 Loss Carcinoma ex pleomorphic adenoma
3 44907 10 64800000 71300000 Loss Carcinoma ex pleomorphic adenoma
4 67036 12 35400000 132349534 Amplification HMGA2 Carcinoma ex pleomorphic adenoma
5 67038 12 35400000 132349534 Amplification MDM2 Carcinoma ex pleomorphic adenoma
6 89426 15 18400000 23300000 Loss Carcinoma ex pleomorphic adenoma
7 112095 17 37856254 37884915 Amplification ERBB2 Carcinoma ex pleomorphic adenoma
8 146803 2 54800000 83700000 Amplification Carcinoma ex pleomorphic adenoma
9 192955 5 121500000 139000000 Loss Carcinoma ex pleomorphic adenoma
10 230836 8 1 45200000 Loss Carcinoma ex pleomorphic adenoma
11 240831 8 55600000 61700000 Amplification PLAG1 Carcinoma ex pleomorphic adenoma
12 241224 8 59800000 127300000 Amplification MYC Carcinoma ex pleomorphic adenoma

Expression for Pleomorphic Adenoma Carcinoma

Search GEO for disease gene expression data for Pleomorphic Adenoma Carcinoma.

Pathways for Pleomorphic Adenoma Carcinoma

Pathways related to Pleomorphic Adenoma Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.81 ERBB2 HMGA2 TP53
2 11.23 ERBB2 TP53
3 11.18 ERBB2 TP53
4 11.07 ERBB2 TP53
5 10.62 CNTN6 ERBB2 TP53
6 10.39 CNTN6 MAML2

GO Terms for Pleomorphic Adenoma Carcinoma

Biological processes related to Pleomorphic Adenoma Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.43 ERBB2 HMGA2 TP53
2 positive regulation of Notch signaling pathway GO:0045747 9.16 CNTN6 MAML2
3 base-excision repair GO:0006284 8.96 HMGA2 TP53
4 positive regulation of cell cycle arrest GO:0071158 8.62 HMGA2 TP53

Molecular functions related to Pleomorphic Adenoma Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 8.62 ERBB2 TP53

Sources for Pleomorphic Adenoma Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....