MCID: PLM009
MIFTS: 33

Pleomorphic Adenoma Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Pleomorphic Adenoma Carcinoma

MalaCards integrated aliases for Pleomorphic Adenoma Carcinoma:

Name: Pleomorphic Adenoma Carcinoma 12 15
Carcinoma Ex Pleomorphic Adenoma 12 70
Carcinoma in Pleomorphic Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:297
NCIt 50 C4397
SNOMED-CT 67 17264009
UMLS 70 C0344460

Summaries for Pleomorphic Adenoma Carcinoma

MalaCards based summary : Pleomorphic Adenoma Carcinoma, also known as carcinoma ex pleomorphic adenoma, is related to salivary gland adenoma, pleomorphic and myoepithelial carcinoma. An important gene associated with Pleomorphic Adenoma Carcinoma is PLAG1 (PLAG1 Zinc Finger), and among its related pathways/superpathways are MAPK Signaling: Mitogen Stimulation Pathway and Central carbon metabolism in cancer. Affiliated tissues include salivary gland, breast and brain, and related phenotypes are Decreased TP53 mRNA expression and Decreased TP53 mRNA expression

Wikipedia : 73 Carcinoma ex pleomorphic adenoma (ca ex PA) is a type of cancer typically found in the parotid gland. It... more...

Related Diseases for Pleomorphic Adenoma Carcinoma

Diseases related to Pleomorphic Adenoma Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 salivary gland adenoma, pleomorphic 31.0 PLAG1 HMGA2
2 myoepithelial carcinoma 31.0 TP53 PLAG1 HMGA2
3 epithelial-myoepithelial carcinoma 30.6 TP53 PLAG1 HMGA2
4 lipomatosis, multiple 30.4 PLAG1 NFIB HMGA2
5 comedo carcinoma 30.1 TP53 ERBB2
6 keratinizing squamous cell carcinoma 30.1 TP53 MAML2
7 adenoid cystic carcinoma 30.0 TP53 PLAG1 NTRK3 NFIB ERBB2
8 mucoepidermoid carcinoma 29.9 TP53 MAML2 HMGA2 ERBB2 CRTC3 CRTC1
9 small cell carcinoma 29.9 TP53 ERBB2 AR
10 sebaceous adenocarcinoma 29.7 TP53 ERBB2 AR
11 ductal carcinoma in situ 29.6 TP53 ERBB2 AR
12 breast ductal carcinoma 29.5 TP53 ERBB2 AR
13 salivary gland carcinoma 29.0 TP53 PLAG1 NTRK3 NFIB MAML2 ERBB2
14 pleomorphic adenoma 28.6 TP53 PLAG1 MAML2 HMGA2 ERBB2 CRTC1
15 mixed lacrimal gland cancer 11.6
16 adenocarcinoma 10.6
17 carcinosarcoma 10.5
18 squamous cell carcinoma 10.4
19 rare tumor 10.4
20 facial paralysis 10.4
21 in situ carcinoma 10.4
22 silver-russell syndrome due to a point mutation 10.3 PLAG1 HMGA2
23 exophthalmos 10.3
24 chondroid lipoma 10.3 PLAG1 HMGA2
25 vulvar leiomyoma 10.3 PLAG1 HMGA2
26 lacrimal gland mucoepidermoid carcinoma 10.3 MAML2 CRTC1
27 schneiderian carcinoma 10.3 MAML2 CRTC1
28 cutaneous mucoepidermoid carcinoma 10.3 MAML2 CRTC1
29 breast mucoepidermoid carcinoma 10.3 MAML2 CRTC1
30 bile duct mucoepidermoid carcinoma 10.3 MAML2 CRTC1
31 infiltrating lipoma 10.3 NFIB HMGA2
32 breast metaplastic carcinoma 10.3 MAML2 ERBB2
33 endobronchial lipoma 10.3 MAML2 CRTC1
34 cervical adenosquamous carcinoma 10.3 MAML2 CRTC1
35 large intestine lipoma 10.3 NFIB HMGA2
36 chromosomal triplication 10.3
37 lipoma of colon 10.2 NFIB HMGA2
38 eccrine papillary adenoma 10.2 PLAG1 HMGA2
39 vulvar benign neoplasm 10.2 PLAG1 HMGA2
40 human t-cell leukemia virus type 1 10.2 CRTC3 CRTC1
41 lipid-rich carcinoma 10.1 NTRK3 ERBB2
42 intraductal breast benign neoplasm 10.1 MFSD1 ERBB2
43 breast secretory carcinoma 10.1 NTRK3 NFIB
44 lung adenoid cystic carcinoma 10.1 NFIB MAML2 CRTC1
45 warthin tumor 10.1 MAML2 CRTC3 CRTC1
46 clear cell hidradenoma 10.1 MAML2 CRTC3 CRTC1
47 hidradenoma 10.1 MAML2 CRTC3 CRTC1
48 pancreatic adenosquamous carcinoma 10.1 MAML2 CRTC3 CRTC1
49 oncocytic breast carcinoma 10.1 ERBB2 AR
50 hyperhidrosis, gustatory 10.1

Graphical network of the top 20 diseases related to Pleomorphic Adenoma Carcinoma:



Diseases related to Pleomorphic Adenoma Carcinoma

Symptoms & Phenotypes for Pleomorphic Adenoma Carcinoma

GenomeRNAi Phenotypes related to Pleomorphic Adenoma Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased TP53 mRNA expression GR00389-S-5 8.8 TP53
2 Decreased TP53 mRNA expression GR00389-S-6 8.8 HMGA2 TP53

MGI Mouse Phenotypes related to Pleomorphic Adenoma Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.5 AR CRTC1 ERBB2 MFSD1 NFIB PLAG1
2 vision/eye MP:0005391 9.17 CRTC3 MFSD1 NFIB NTRK3 PLAG1 TP53

Drugs & Therapeutics for Pleomorphic Adenoma Carcinoma

Search Clinical Trials , NIH Clinical Center for Pleomorphic Adenoma Carcinoma

Genetic Tests for Pleomorphic Adenoma Carcinoma

Anatomical Context for Pleomorphic Adenoma Carcinoma

MalaCards organs/tissues related to Pleomorphic Adenoma Carcinoma:

40
Salivary Gland, Breast, Brain, Lymph Node, Trachea, Eye, Bone

Publications for Pleomorphic Adenoma Carcinoma

Articles related to Pleomorphic Adenoma Carcinoma:

(show top 50) (show all 429)
# Title Authors PMID Year
1
Surgery combined with 125I brachytherapy for treatment of carcinoma ex pleomorphic adenoma of the parotid gland. 61
33610540 2021
2
Salivary Duct Carcinoma With Rhabdoid Features-No or Aberrant Expression of E-cadherin and Genetic Changes in CDH1: Immunohistochemical and Genetic Analyses of 17 Cases. 61
33538422 2021
3
Secretory carcinoma ex pleomorphic adenoma of the submandibular gland: An immunohistochemical study. 61
33773910 2021
4
Myoepithelial Carcinoma. 61
33526224 2021
5
Carcinoma Expleomorphic Adenoma of the Lacrimal Gland. 61
33710040 2021
6
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective. 61
33405400 2021
7
Re: "Malignant Mixed Tumor (Carcinoma Ex Pleomorphic Adenoma) of the Lacrimal Gland". 61
33661769 2021
8
Reply re: "Malignant Mixed Tumor (Carcinoma Ex Pleomorphic Adenoma) of the Lacrimal Gland". 61
33661770 2021
9
Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma. 61
33591488 2021
10
Clinical outcomes of bulky parotid gland cancers: need for self-examination and screening program for early diagnosis of parotid tumors. 61
33602169 2021
11
Risk factors for carcinoma ex pleomorphic adenoma in patients presenting with recurrence after resection of pleomorphic adenoma. 61
33043539 2021
12
The accurate cytological diagnosis of salivary carcinoma ex pleomorphic adenoma may be hampered by myoepithelial differentiation. 61
33528074 2021
13
Outcomes of carcinoma ex pleomorphic adenoma compared to de novo adenocarcinoma of major salivary glands. 61
33145786 2021
14
Two sides of the same coin: Insights into the myoepithelial cells in carcinoma ex pleomorphic adenoma development. 61
33307199 2021
15
Incidence and profile of benign epithelial tumors of salivary glands from a single center in Northeast of Brazil. 61
33247571 2021
16
Carcinoma Ex-Pleomorphic Adenoma Diagnosis During Global Health Engagement Operations. 61
33499534 2021
17
Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Maxillary Sinus: A Case Report and Review of Literature. 61
33394378 2021
18
Parapharyngeal space carcinoma ex pleomorphic adenoma: case report and literature review. 61
33451918 2021
19
Nasopharyngeal Carcinoma Ex Pleomorphic Adenoma: Case Report and Comprehensive Literature Review. 61
33728082 2021
20
Salivary duct carcinoma and small cell carcinoma ex-pleomorphic adenoma: A heretofore undescribed entity and the naming conundrum: MiNEN, combined, collision, or composite tumor? 61
33741286 2021
21
Mixed response and mechanisms of resistance to larotrectinib in metastatic carcinoma ex pleomorphic adenoma of the parotid harboring an NTRK2 fusion: A case report. 61
33530256 2021
22
Corrigendum: High grade carcinoma ex pleomorphic adenoma of parotid gland: a case report. 61
33377474 2020
23
Pleomorphic Adenoma: The Great Mimicker of Malignancy. 61
33368685 2020
24
Clinicopathologic Features and Prognostic Factors of Widely Invasive Carcinoma Ex Pleomorphic Adenoma of Parotid Gland: A Clinicopathologic Analysis of 126 Cases in a Chinese Population. 61
32649893 2020
25
Squamous carcinoma ex pleomorphic adenoma of the lacrimal gland. 61
33172316 2020
26
High grade carcinoma ex pleomorphic adenoma of parotid gland: a case report. 61
33122460 2020
27
Malignant Mixed Tumor (Carcinoma Ex Pleomorphic Adenoma) of the Lacrimal Gland. 61
32282452 2020
28
Microvesicles derived from squamous cell carcinoma induce cell death, autophagy, and invasion of benign myoepithelial cells. 61
32453894 2020
29
Three unusual parapharyngeal space masses resected via the endoscopy-assisted transoral approach: case series and literature review. 61
32865073 2020
30
Epithelial-myoepithelial carcinoma ex-pleomorphic adenoma of the parotid gland: report of a rare case with immunohistochemical and genetic analyses. 61
32749544 2020
31
Carcinoma ex pleomorphic adenoma in nasal cavity: an unusual diagnosis. 61
32828525 2020
32
An Uncommon Recurrence of Carcinoma Ex Pleomorphic Adenoma. 61
32790584 2020
33
Prognostic Impact of PD-L1 Expression in Malignant Salivary Gland Tumors as Assessed by Established Scoring Criteria: Tumor Proportion Score (TPS), Combined Positivity Score (CPS), and Immune Cell (IC) Infiltrate. 61
32260165 2020
34
Gene and immunohistochemical expression of HIF-1α, GLUT-1, FASN, and adipophilin in carcinoma ex pleomorphic adenoma development. 61
32180291 2020
35
Diagnostic performance and inter-operator variability of apparent diffusion coefficient analysis for differentiating pleomorphic adenoma and carcinoma ex pleomorphic adenoma: comparing one-point measurement and whole-tumor measurement including radiomics approach. 61
31820265 2020
36
Clinical difference between benign and malignant tumors of the hard palate. 61
31828419 2020
37
Acantholytic Squamous Cell Carcinoma and Salivary Duct Carcinoma Ex-pleomorphic Adenoma of the Submandibular Gland: A Report of Two Extremely Rare Cases with an Immunohistochemical Analysis. 61
30484070 2020
38
Primary Pleomorphic Lipoma of the Parotid Gland with Prominent Myxoid Change: Report of a Rare Case Mimicking Carcinoma Ex Pleomorphic Adenoma on Fine Needle Aspiration Cytology. 61
30610525 2020
39
Cytological features of carcinoma ex pleomorphic adenoma of the salivary glands: A diagnostic challenge. 61
31675185 2020
40
Ductal Adenocarcinoma Ex Pleomorphic Adenoma of the Lacrimal Gland: a Rare and Morbid Malignancy. 61
32089922 2020
41
A Rare De Novo Myoepithelial Carcinoma Ex Pleomorphic Adenoma in a Young Woman. 61
32158581 2020
42
Enhanced Angiogenesis in Salivary Duct Carcinoma Ex-Pleomorphic Adenoma. 61
33692941 2020
43
Carcinoma ex Pleomorphic Adenoma in the Floor of the Mouth: An Unusual Diagnosis in a Rare Location. 61
32855949 2020
44
A case of giant sarcomatoid carcinoma ex-pleomorphic adenoma of the parotid gland. 61
32983320 2020
45
Intracapsular High-Grade Ductal Carcinoma In-Situ Ex Pleomorphic Adenoma of the Lacrimal Gland. 61
31743286 2020
46
Invasive Carcinoma Ex-Pleomorphic Adenoma of the Lacrimal Gland with a Cystadenocarcinoma Component: A Case Report and Review of the Literature. 61
32850170 2020
47
Utility of neck dissection for management of carcinoma of the parotid gland. 61
31564483 2019
48
Postoperative complications after removal of pleomorphic adenoma from the parotid gland: A long-term follow up of 297 patients from 2002 to 2016 and a review of publications. 61
31500918 2019
49
Carcinoma ex pleomorphic adenoma: a case report and review of literature. 61
32127904 2019
50
Pleomorphic adenoma with bizarre myoepithelial cells: A diagnostic challenge on cytologic smear. 61
31400260 2019

Variations for Pleomorphic Adenoma Carcinoma

Copy number variations for Pleomorphic Adenoma Carcinoma from CNVD:

7 (show all 12)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 16422 1 124300000 205300000 Amplification Carcinoma ex pleomorphic adenoma
2 37764 1 94500000 107000000 Loss Carcinoma ex pleomorphic adenoma
3 44907 10 64800000 71300000 Loss Carcinoma ex pleomorphic adenoma
4 67036 12 35400000 132349534 Amplification HMGA2 Carcinoma ex pleomorphic adenoma
5 67038 12 35400000 132349534 Amplification MDM2 Carcinoma ex pleomorphic adenoma
6 89426 15 18400000 23300000 Loss Carcinoma ex pleomorphic adenoma
7 112095 17 37856254 37884915 Amplification ERBB2 Carcinoma ex pleomorphic adenoma
8 146803 2 54800000 83700000 Amplification Carcinoma ex pleomorphic adenoma
9 192955 5 121500000 139000000 Loss Carcinoma ex pleomorphic adenoma
10 230836 8 1 45200000 Loss Carcinoma ex pleomorphic adenoma
11 240831 8 55600000 61700000 Amplification PLAG1 Carcinoma ex pleomorphic adenoma
12 241224 8 59800000 127300000 Amplification MYC Carcinoma ex pleomorphic adenoma

Expression for Pleomorphic Adenoma Carcinoma

Search GEO for disease gene expression data for Pleomorphic Adenoma Carcinoma.

Pathways for Pleomorphic Adenoma Carcinoma

Pathways related to Pleomorphic Adenoma Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.64 TP53 NTRK3 ERBB2 AR
2 10.98 TP53 NTRK3 ERBB2
3 10.62 TP53 NFIB ERBB2

GO Terms for Pleomorphic Adenoma Carcinoma

Cellular components related to Pleomorphic Adenoma Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.28 YIPF5 TP53 PLAG1 NFIB MAML2 HMGA2

Biological processes related to Pleomorphic Adenoma Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.5 NTRK3 ERBB2 AR
2 multicellular organism growth GO:0035264 9.43 TP53 PLAG1 AR
3 positive regulation of gene expression GO:0010628 9.43 TP53 PLAG1 NTRK3 HMGA2 ERBB2 AR
4 entrainment of circadian clock by photoperiod GO:0043153 9.4 TP53 CRTC1
5 positive regulation of CREB transcription factor activity GO:0032793 9.37 CRTC3 CRTC1
6 positive regulation of transcription by RNA polymerase II GO:0045944 9.23 TP53 PLAG1 NFIB MAML2 HMGA2 CRTC3
7 prostate gland growth GO:0060736 9.16 PLAG1 AR

Molecular functions related to Pleomorphic Adenoma Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.26 TP53 PLAG1 NFIB AR
2 cAMP response element binding protein binding GO:0008140 8.62 CRTC3 CRTC1

Sources for Pleomorphic Adenoma Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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