MCID: PLM016
MIFTS: 38

Pleomorphic Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Pleomorphic Carcinoma

MalaCards integrated aliases for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5662
NCIt 50 C4094
SNOMED-CT 68 16741004
UMLS 73 C0334233

Summaries for Pleomorphic Carcinoma

Disease Ontology : 12 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary : Pleomorphic Carcinoma is related to intestinal perforation and large cell carcinoma. An important gene associated with Pleomorphic Carcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Developmental Biology and Pathways in cancer. Affiliated tissues include lung, pancreas and thyroid, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Pleomorphic Carcinoma

Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 intestinal perforation 30.6 KRT7 NKX2-1
2 large cell carcinoma 30.0 EGFR KRT7 NKX2-1
3 adenocarcinoma 29.0 ALK EGFR KIT TP53
4 small cell carcinoma 28.0 EGFR KIT KRT7 NKX2-1 TP53
5 lung cancer 25.9 ALK EGFR KIT KRT18 KRT7 NKX2-1
6 benign breast adenomyoepithelioma 10.7 EGFR KRT7
7 oncocytic breast carcinoma 10.7 EGFR KRT7
8 solid adenocarcinoma with mucin production 10.7 KRT7 NKX2-1
9 ovarian germ cell teratoma 10.6 KRT7 NKX2-1
10 lung acinar adenocarcinoma 10.6 KRT7 NKX2-1
11 small cell carcinoma of the bladder 10.6 KRT7 NKX2-1
12 ovarian germ cell cancer 10.6 KRT7 NKX2-1
13 mucinous bronchioloalveolar adenocarcinoma 10.6 KRT7 NKX2-1
14 papillary adenoma 10.6 KRT7 NKX2-1
15 pulmonary sclerosing hemangioma 10.6 KRT7 NKX2-1
16 brain ependymoma 10.6 EGFR TP53
17 sclerosing hemangioma 10.5 KRT7 NKX2-1
18 malignant spiradenoma 10.5 KRT7 TP53
19 jejunal cancer 10.5 KIT KRT7
20 breast adenoid cystic carcinoma 10.5 EGFR KIT
21 female reproductive endometrioid cancer 10.5 KRT7 TP53
22 breast squamous cell carcinoma 10.5 EGFR TP53
23 eccrine sweat gland neoplasm 10.5 KRT7 TP53
24 ovarian cystic teratoma 10.5 KRT7 NKX2-1
25 adenosquamous cell lung carcinoma 10.5 ALK EGFR
26 cribriform carcinoma 10.5 KIT KRT7
27 malignant mixed mullerian tumor 10.5 KIT KRT7
28 adenoid basal cell carcinoma 10.5 KIT KRT7
29 bladder carcinoma in situ 10.5 KRT7 TP53
30 intratubular embryonal carcinoma 10.5 KIT KRT7
31 malignant leydig cell tumor 10.5 KIT KRT7
32 nasal cavity adenocarcinoma 10.5 KRT7 TP53
33 spiradenoma 10.5 KRT7 TP53
34 benign mesothelioma 10.5 KRT7 NKX2-1
35 glycogen-rich clear cell breast carcinoma 10.5 KRT7 TP53
36 gliomatosis cerebri 10.5 EGFR TP53
37 oropharynx cancer 10.5 EGFR TP53
38 soft tissue sarcoma 10.5 EGFR TP53
39 kidney benign neoplasm 10.4 KIT KRT7
40 esophageal basaloid squamous cell carcinoma 10.4 EGFR TP53
41 biliary papillomatosis 10.4 KRT7 TP53
42 chordoid glioma 10.4 NKX2-1 TP53
43 parameningeal embryonal rhabdomyosarcoma 10.4 ALK TP53
44 rete testis adenocarcinoma 10.4 KIT NKX2-1
45 endocervical adenocarcinoma 10.4 KRT7 TP53
46 dermoid cyst 10.4 KIT KRT7
47 lung papillary adenocarcinoma 10.4 ALK TP53
48 in situ pulmonary adenocarcinoma 10.4 ALK EGFR
49 ovary adenocarcinoma 10.4 KRT7 TP53
50 endolymphatic sac tumor 10.4 KRT7 KRT8

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to Pleomorphic Carcinoma

Symptoms & Phenotypes for Pleomorphic Carcinoma

GenomeRNAi Phenotypes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.73 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.73 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.73 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.73 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.73 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.73 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.73 KRT8 KRT18 KRT7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.73 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.73 KRT18
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.73 KRT7
11 Decreased substrate adherent cell growth GR00193-A-1 9.02 KIT
12 Decreased substrate adherent cell growth GR00193-A-2 9.02 ALK EGFR KIT
13 Decreased substrate adherent cell growth GR00193-A-4 9.02 KIT

MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10 KIT TP53 KRT18 ALK KRT8 EGFR
2 homeostasis/metabolism MP:0005376 9.95 NKX2-1 KIT KRT7 ALK KRT8 EGFR
3 digestive/alimentary MP:0005381 9.89 NKX2-1 KIT TP53 KRT8 EGFR
4 embryo MP:0005380 9.88 EGFR KIT KRT18 KRT8 TP53
5 mortality/aging MP:0010768 9.87 EGFR NKX2-1 KIT KRT18 ALK KRT8
6 liver/biliary system MP:0005370 9.77 KIT TP53 KRT18 KRT8 EGFR
7 hearing/vestibular/ear MP:0005377 9.73 KIT KRT8 EGFR TP53
8 neoplasm MP:0002006 9.65 KIT TP53 ALK EGFR NKX2-1
9 pigmentation MP:0001186 9.46 KIT TP53 ALK EGFR
10 reproductive system MP:0005389 9.43 KIT TP53 ALK KRT8 EGFR NKX2-1
11 respiratory system MP:0005388 9.02 NKX2-1 KIT TP53 ALK EGFR

Drugs & Therapeutics for Pleomorphic Carcinoma

Search Clinical Trials , NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

Anatomical Context for Pleomorphic Carcinoma

MalaCards organs/tissues related to Pleomorphic Carcinoma:

41
Lung, Pancreas, Thyroid, Colon, Brain, Tongue, T Cells

Publications for Pleomorphic Carcinoma

Articles related to Pleomorphic Carcinoma:

(show top 50) (show all 137)
# Title Authors Year
1
Air bronchogram in pleomorphic carcinoma of the lung is associated with favorable prognosis. ( 29624900 )
2018
2
Pulmonary pleomorphic carcinoma with few PD-1-positive immune cells and regulatory T cells that showed a complete response to nivolumab. ( 29131510 )
2018
3
What's in a giant cell? A case of metastatic sarcomatoid pleomorphic carcinoma with osteoclast-like giant cells involving the thyroid. ( 29473224 )
2018
4
Nivolumab-induced Limbic Encephalitis with Anti-Hu Antibody in a Patient With Advanced Pleomorphic Carcinoma of the Lung. ( 29857970 )
2018
5
Anaplastic lymphoma kinase (ALK)-rearranged pulmonary pleomorphic carcinoma successfully treated with crizotinib. ( 29310482 )
2018
6
Programmed death-ligand 1 (PD-L1) expression in pleomorphic carcinoma of the lung. ( 29601633 )
2018
7
Tumor spread through air spaces identifies a distinct subgroup with poor prognosis in surgically resected lung pleomorphic carcinoma. ( 29932891 )
2018
8
Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report. ( 29928213 )
2018
9
An unusual case of duodenal metastasis of pulmonary pleomorphic carcinoma. ( 29391323 )
2018
10
Pulmonary pleomorphic carcinoma: A case harboring EGFR mutation treated with EGFR-TKIs. ( 29675860 )
2018
11
Breast metastasis of pulmonary pleomorphic carcinoma: a case report. ( 28188513 )
2017
12
MET exon 14 skipping mutation in triple-negative pulmonary adenocarcinomas and pleomorphic carcinomas: An analysis of intratumoral MET status heterogeneity and clinicopathological characteristics. ( 28285687 )
2017
13
Stage IV pleomorphic carcinoma of the lung without recurrence for 6A years: a case report. ( 28224563 )
2017
14
Marked response to pembrolizumab in a patient with pulmonary pleomorphic carcinoma highly positive for PD-L1. ( 28754417 )
2017
15
Successful Resection of G719X-Positive Pleomorphic Carcinoma after Afatinib Treatment. ( 29515394 )
2017
16
The Successful Treatment of Pulmonary Pleomorphic Carcinoma with Pembrolizumab: A Case Report. ( 28878661 )
2017
17
Atrial Involvement in Pleomorphic Carcinoma of the Lung. ( 28883256 )
2017
18
Pulmonary pleomorphic carcinoma: A case report and review of the literature. ( 28723756 )
2017
19
Clinicopathological factors influenced the prognosis of surgically resected pulmonary pleomorphic carcinoma. ( 28616281 )
2017
20
Nivolumab-Induced Acute Diabetes Mellitus and Hypophysitis in a Patient with Advanced Pulmonary Pleomorphic Carcinoma with a Prolonged Tumor Response. ( 29074210 )
2017
21
Diffuse fluorodeoxyglucose-positron uptake in the bone marrow of a patient with granulocyte colony-stimulating factor-producing pleomorphic carcinoma of the lung: A case report. ( 28685085 )
2017
22
A rare primary pulmonary tumor with difficult diagnosis: pleomorphic carcinoma. ( 27525610 )
2016
23
High co-expression of PD-L1 and HIF-1I+ correlates with tumour necrosis in pulmonary pleomorphic carcinoma. ( 27107327 )
2016
24
Pemetrexed and bevacizumab-containing chemotherapy for pleomorphic carcinoma of the lung. ( 27073676 )
2016
25
Pleomorphic Carcinoma of the Colon: Morphological and Immunohistochemical Findings. ( 27462191 )
2016
26
Pleomorphic Carcinoma of the Lung: Relationship Between CT Findings and Prognosis. ( 27144416 )
2016
27
&amp;quot;Pseudoprogression&amp;quot; of Pulmonary Pleomorphic Carcinoma during Nivolumab Therapy. ( 27189927 )
2016
28
P1.27: A Clinicopathological Study of ResectedA Pulmonary Pleomorphic Carcinoma: Track: Advanced NSCLC. ( 27676513 )
2016
29
Clinicoradiological outcomes of 33 cases of surgically resected pulmonary pleomorphic carcinoma: correlation with prognostic indicators. ( 25994197 )
2015
30
Comparative analysis of tumor angiogenesis and clinical features of 55 cases of pleomorphic carcinoma and adenocarcinoma of the lung. ( 25550577 )
2015
31
Retrospective analysis of the efficacy of chemotherapy and molecular targeted therapy for advanced pulmonary pleomorphic carcinoma. ( 26682906 )
2015
32
Response to Crizotinib and Clinical Outcome in ALK-Rearranged Pulmonary Pleomorphic Carcinoma. ( 25898961 )
2015
33
Clinicopathological analysis of pleomorphic carcinoma of the lung: diffuse ZEB1 expression predicts poor survival. ( 25479687 )
2015
34
Promising effect of chemotherapy with bevacizumab for patients with pulmonary pleomorphic carcinoma: Two case reports and a literature review. ( 26521107 )
2015
35
A Rare Case of Pleomorphic Carcinoma of the Lung Harboring an Anaplastic Lymphoma Kinase (ALK) Rearrangement. ( 26521903 )
2015
36
Successful treatment of two consecutive cases of pulmonary pleomorphic carcinoma with platinum chemotherapy. ( 26722286 )
2015
37
Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas. ( 26329973 )
2015
38
Anaplastic Lymphoma Kinase (ALK) Rearrangement-positive Lung Cancer with Transformation to Pleomorphic Carcinoma. ( 26568007 )
2015
39
EGFR and KRAS mutations in pulmonary pleomorphic carcinoma and their correlation with clinicopathologic features. ( 26199566 )
2015
40
Tumor-related gene expression levels in pulmonary pleomorphic carcinoma. ( 26031756 )
2015
41
Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. ( 26345631 )
2015
42
Pulmonary pleomorphic carcinoma with multiple metastases to the right posterior knee complicated by paraneoplastic hypercalcemia. ( 24396467 )
2014
43
Long-term survival in a case of pleomorphic carcinoma with a brain metastasis. ( 25566055 )
2014
44
Recurrent intussusception caused by intestinal metastasis of pulmonary pleomorphic carcinoma. ( 24924845 )
2014
45
Bevacizumab for critical brain metastases in a patient with pulmonary pleomorphic carcinoma. ( 25130117 )
2014
46
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. ( 25123545 )
2014
47
Pulmonary Pleomorphic Carcinoma Metastasis to the Midfoot. ( 24840733 )
2014
48
A case of synchronous double primary lung cancer presenting with pleomorphic carcinoma and adenocarcinoma. ( 25553415 )
2014
49
Long-term Complete Response in a Patient with Disseminated Pulmonary Pleomorphic Carcinoma Induced by Cisplatin and Gemcitabine. ( 25400187 )
2014
50
Sarcomatous Components May Predict Prognosis in Patients with Pulmonary Pleomorphic Carcinoma. ( 25423314 )
2014

Variations for Pleomorphic Carcinoma

Expression for Pleomorphic Carcinoma

Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for Pleomorphic Carcinoma

Pathways related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 EGFR KIT KRT18 KRT7 KRT8
2 12.28 ALK EGFR KIT TP53
3 12.12 KRT18 KRT7 KRT8
4
Show member pathways
12.06 KRT18 KRT7 KRT8
5 11.5 ALK EGFR KIT
6
Show member pathways
11.17 KRT18 KRT7 KRT8
7 11.16 ALK KIT
8 10.91 KRT8 TP53
9 10.84 EGFR TP53
10 10.61 EGFR KIT TP53

GO Terms for Pleomorphic Carcinoma

Cellular components related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.33 KRT18 KRT7 KRT8
2 receptor complex GO:0043235 9.13 ALK EGFR KIT
3 keratin filament GO:0045095 8.8 KRT18 KRT7 KRT8

Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.72 ALK EGFR KIT
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.71 ALK EGFR KIT
3 keratinization GO:0031424 9.7 KRT18 KRT7 KRT8
4 protein autophosphorylation GO:0046777 9.69 ALK EGFR KIT
5 peptidyl-tyrosine phosphorylation GO:0018108 9.67 ALK EGFR KIT
6 viral process GO:0016032 9.67 KRT18 KRT7 KRT8 TP53
7 positive regulation of MAPK cascade GO:0043410 9.65 ALK EGFR KIT
8 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.63 ALK EGFR KIT
9 extrinsic apoptotic signaling pathway GO:0097191 9.56 KRT18 KRT8
10 negative regulation of signal transduction GO:0009968 9.5 ALK EGFR KIT
11 cerebral cortex cell migration GO:0021795 9.43 EGFR NKX2-1
12 tongue development GO:0043586 9.4 EGFR KIT
13 cornification GO:0070268 9.33 KRT18 KRT7 KRT8
14 hepatocyte apoptotic process GO:0097284 9.26 KRT18 KRT8
15 positive regulation of kinase activity GO:0033674 9.13 ALK EGFR KIT
16 negative regulation of apoptotic process GO:0043066 9.02 ALK EGFR KIT KRT18 TP53

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.54 KRT18 KRT7 KRT8
2 protein tyrosine kinase activity GO:0004713 9.5 ALK EGFR KIT
3 MAP kinase kinase kinase activity GO:0004709 9.33 ALK EGFR KIT
4 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.26 EGFR KIT
5 mitogen-activated protein kinase kinase binding GO:0031434 9.13 ALK EGFR KIT
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 ALK EGFR KIT

Sources for Pleomorphic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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