MCID: PLM016
MIFTS: 34

Pleomorphic Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Pleomorphic Carcinoma

MalaCards integrated aliases for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5662
NCIt 50 C4094
SNOMED-CT 68 16741004
UMLS 73 C0334233

Summaries for Pleomorphic Carcinoma

Disease Ontology : 12 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary : Pleomorphic Carcinoma is related to intestinal perforation and adenocarcinoma. An important gene associated with Pleomorphic Carcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are MicroRNAs in cancer and Photodynamic therapy-induced AP-1 survival signaling.. Affiliated tissues include lung, pancreas and thyroid, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Pleomorphic Carcinoma

Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 intestinal perforation 30.1 KRT7 NKX2-1
2 adenocarcinoma 30.0 ALK EGFR TP53
3 large cell carcinoma 29.9 EGFR KRT7 NKX2-1
4 small cell carcinoma 29.4 EGFR KRT7 NKX2-1 TP53
5 lung cancer 29.1 ALK CD274 EGFR KRT7 NKX2-1 TP53
6 benign breast adenomyoepithelioma 10.2 EGFR KRT7
7 oncocytic breast carcinoma 10.2 EGFR KRT7
8 cervical adenosquamous carcinoma 10.2 EGFR KRT7
9 anal canal adenocarcinoma 10.2 CD274 KRT7
10 solid adenocarcinoma with mucin production 10.2 KRT7 NKX2-1
11 ovarian germ cell teratoma 10.2 KRT7 NKX2-1
12 lung acinar adenocarcinoma 10.2 KRT7 NKX2-1
13 small cell carcinoma of the bladder 10.2 KRT7 NKX2-1
14 ovarian germ cell cancer 10.2 KRT7 NKX2-1
15 papillary adenoma 10.2 KRT7 NKX2-1
16 pulmonary sclerosing hemangioma 10.2 KRT7 NKX2-1
17 sclerosing hemangioma 10.2 KRT7 NKX2-1
18 adenomatoid tumor 10.2 KRT7 NKX2-1
19 mucinous bronchioloalveolar adenocarcinoma 10.2 KRT7 NKX2-1
20 alveoli adenoma 10.2 KRT7 NKX2-1
21 ovarian cystic teratoma 10.1 KRT7 NKX2-1
22 pharynx cancer 10.1 EGFR TP53
23 brain ependymoma 10.1 EGFR TP53
24 mucinous lung adenocarcinoma 10.1 ALK EGFR
25 adenosquamous lung carcinoma 10.1 ALK EGFR
26 breast squamous cell carcinoma 10.1 EGFR TP53
27 malignant spiradenoma 10.1 KRT7 TP53
28 spiradenoma 10.1 KRT7 TP53
29 vulvar intraepithelial neoplasia 10.1 KRT7 TP53
30 lung adenoid cystic carcinoma 10.1 ALK NKX2-1
31 alk-negative anaplastic large cell lymphoma 10.1 ALK CD274
32 microglandular adenosis 10.1 EGFR TP53
33 in situ pulmonary adenocarcinoma 10.1 ALK EGFR
34 corneal dystrophy, posterior polymorphous, 3 10.1 KRT7 ZEB1
35 bladder carcinoma in situ 10.1 KRT7 TP53
36 gliomatosis cerebri 10.1 EGFR TP53
37 vulvar disease 10.1 KRT7 TP53
38 soft tissue sarcoma 10.1 EGFR TP53
39 nasal cavity adenocarcinoma 10.1 KRT7 TP53
40 female reproductive endometrioid cancer 10.1 KRT7 TP53
41 glycogen-rich clear cell breast carcinoma 10.1 KRT7 TP53
42 esophageal basaloid squamous cell carcinoma 10.1 EGFR TP53
43 biliary papillomatosis 10.1 KRT7 TP53
44 endocervical adenocarcinoma 10.1 KRT7 TP53
45 cervical adenocarcinoma 10.1 KRT7 TP53
46 eccrine sweat gland neoplasm 10.1 KRT7 TP53
47 appendix cancer 10.1 KRT7 TP53
48 epithelial-myoepithelial carcinoma 10.1 KRT7 TP53
49 necrotizing sialometaplasia 10.1 KRT7 TP53
50 primary peritoneal carcinoma 10.1 EGFR TP53

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to Pleomorphic Carcinoma

Symptoms & Phenotypes for Pleomorphic Carcinoma

MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 ALK CD274 EGFR KRT7 KRT8 NKX2-1
2 mortality/aging MP:0010768 9.91 ALK CD274 EGFR KRT8 NKX2-1 TP53
3 digestive/alimentary MP:0005381 9.88 EGFR KRT8 NKX2-1 TP53 ZEB1
4 integument MP:0010771 9.8 ALK CD274 EGFR TP53 ZEB1
5 hearing/vestibular/ear MP:0005377 9.76 EGFR KRT8 TP53 ZEB1
6 neoplasm MP:0002006 9.72 ALK EGFR NKX2-1 TP53 ZEB1
7 reproductive system MP:0005389 9.63 ALK EGFR KRT8 NKX2-1 TP53 ZEB1
8 pigmentation MP:0001186 9.56 ALK EGFR TP53 ZEB1
9 respiratory system MP:0005388 9.35 ALK EGFR NKX2-1 TP53 ZEB1
10 skeleton MP:0005390 9.1 ALK CD274 EGFR NKX2-1 TP53 ZEB1

Drugs & Therapeutics for Pleomorphic Carcinoma

Search Clinical Trials , NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

Anatomical Context for Pleomorphic Carcinoma

MalaCards organs/tissues related to Pleomorphic Carcinoma:

41
Lung, Pancreas, Thyroid, Brain, Colon, Ovary, Thymus

Publications for Pleomorphic Carcinoma

Articles related to Pleomorphic Carcinoma:

(show top 50) (show all 144)
# Title Authors Year
1
Air bronchogram in pleomorphic carcinoma of the lung is associated with favorable prognosis. ( 29624900 )
2018
2
Pulmonary pleomorphic carcinoma with few PD-1-positive immune cells and regulatory T cells that showed a complete response to nivolumab. ( 29131510 )
2018
3
What's in a giant cell? A case of metastatic sarcomatoid pleomorphic carcinoma with osteoclast-like giant cells involving the thyroid. ( 29473224 )
2018
4
Nivolumab-induced Limbic Encephalitis with Anti-Hu Antibody in a Patient With Advanced Pleomorphic Carcinoma of the Lung. ( 29857970 )
2018
5
Anaplastic lymphoma kinase (ALK)-rearranged pulmonary pleomorphic carcinoma successfully treated with crizotinib. ( 29310482 )
2018
6
Programmed death-ligand 1 (PD-L1) expression in pleomorphic carcinoma of the lung. ( 29601633 )
2018
7
Tumor spread through air spaces identifies a distinct subgroup with poor prognosis in surgically resected lung pleomorphic carcinoma. ( 29932891 )
2018
8
Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report. ( 29928213 )
2018
9
An unusual case of duodenal metastasis of pulmonary pleomorphic carcinoma. ( 29391323 )
2018
10
Pulmonary pleomorphic carcinoma: A case harboring EGFR mutation treated with EGFR-TKIs. ( 29675860 )
2018
11
Pleomorphic carcinoma of the lung mimicking synchronous pulmonary adenocarcinoma and small bowel sarcoma. ( 30416598 )
2018
12
Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis. ( 30364514 )
2018
13
Pulmonary pleomorphic carcinoma with pseudoprogression during nivolumab therapy and the usefulness of tumor markers: A case report. ( 29988633 )
2018
14
Efficacy of mesna, doxorubicin, ifosfamide, and dacarbazine (MAID) in patients with advanced pulmonary pleomorphic carcinoma. ( 30032825 )
2018
15
A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition. ( 30112272 )
2018
16
Clinicopathological characteristics and prognosis of pulmonary pleomorphic carcinoma: a population-based retrospective study using SEER data. ( 30174872 )
2018
17
Effective combined therapy with ramucirumab for advanced pulmonary pleomorphic carcinoma. ( 30275953 )
2018
18
Expression of amino acid transporter (LAT1 and 4F2hc) in pulmonary pleomorphic carcinoma. ( 30300664 )
2018
19
Breast metastasis of pulmonary pleomorphic carcinoma: a case report. ( 28188513 )
2017
20
Stage IV pleomorphic carcinoma of the lung without recurrence for 6A years: a case report. ( 28224563 )
2017
21
Marked response to pembrolizumab in a patient with pulmonary pleomorphic carcinoma highly positive for PD-L1. ( 28754417 )
2017
22
Successful Resection of G719X-Positive Pleomorphic Carcinoma after Afatinib Treatment. ( 29515394 )
2017
23
The Successful Treatment of Pulmonary Pleomorphic Carcinoma with Pembrolizumab: A Case Report. ( 28878661 )
2017
24
Atrial Involvement in Pleomorphic Carcinoma of the Lung. ( 28883256 )
2017
25
Pulmonary pleomorphic carcinoma: A case report and review of the literature. ( 28723756 )
2017
26
Clinicopathological factors influenced the prognosis of surgically resected pulmonary pleomorphic carcinoma. ( 28616281 )
2017
27
Diffuse fluorodeoxyglucose-positron uptake in the bone marrow of a patient with granulocyte colony-stimulating factor-producing pleomorphic carcinoma of the lung: A case report. ( 28685085 )
2017
28
Nivolumab-Induced Acute Diabetes Mellitus and Hypophysitis in a Patient with Advanced Pulmonary Pleomorphic Carcinoma with a Prolonged Tumor Response. ( 29074210 )
2017
29
A rare primary pulmonary tumor with difficult diagnosis: pleomorphic carcinoma. ( 27525610 )
2016
30
High co-expression of PD-L1 and HIF-1I+ correlates with tumour necrosis in pulmonary pleomorphic carcinoma. ( 27107327 )
2016
31
Pemetrexed and bevacizumab-containing chemotherapy for pleomorphic carcinoma of the lung. ( 27073676 )
2016
32
Pleomorphic Carcinoma of the Colon: Morphological and Immunohistochemical Findings. ( 27462191 )
2016
33
Pleomorphic Carcinoma of the Lung: Relationship Between CT Findings and Prognosis. ( 27144416 )
2016
34
"Pseudoprogression" of Pulmonary Pleomorphic Carcinoma during Nivolumab Therapy. ( 27189927 )
2016
35
P1.27: A Clinicopathological Study of ResectedA Pulmonary Pleomorphic Carcinoma: Track: Advanced NSCLC. ( 27676513 )
2016
36
Clinicoradiological outcomes of 33 cases of surgically resected pulmonary pleomorphic carcinoma: correlation with prognostic indicators. ( 25994197 )
2015
37
Comparative analysis of tumor angiogenesis and clinical features of 55 cases of pleomorphic carcinoma and adenocarcinoma of the lung. ( 25550577 )
2015
38
Retrospective analysis of the efficacy of chemotherapy and molecular targeted therapy for advanced pulmonary pleomorphic carcinoma. ( 26682906 )
2015
39
Response to Crizotinib and Clinical Outcome in ALK-Rearranged Pulmonary Pleomorphic Carcinoma. ( 25898961 )
2015
40
Clinicopathological analysis of pleomorphic carcinoma of the lung: diffuse ZEB1 expression predicts poor survival. ( 25479687 )
2015
41
Promising effect of chemotherapy with bevacizumab for patients with pulmonary pleomorphic carcinoma: Two case reports and a literature review. ( 26521107 )
2015
42
A Rare Case of Pleomorphic Carcinoma of the Lung Harboring an Anaplastic Lymphoma Kinase (ALK) Rearrangement. ( 26521903 )
2015
43
Successful treatment of two consecutive cases of pulmonary pleomorphic carcinoma with platinum chemotherapy. ( 26722286 )
2015
44
Anaplastic Lymphoma Kinase (ALK) Rearrangement-positive Lung Cancer with Transformation to Pleomorphic Carcinoma. ( 26568007 )
2015
45
EGFR and KRAS mutations in pulmonary pleomorphic carcinoma and their correlation with clinicopathologic features. ( 26199566 )
2015
46
Tumor-related gene expression levels in pulmonary pleomorphic carcinoma. ( 26031756 )
2015
47
Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. ( 26345631 )
2015
48
Pulmonary pleomorphic carcinoma with multiple metastases to the right posterior knee complicated by paraneoplastic hypercalcemia. ( 24396467 )
2014
49
Long-term survival in a case of pleomorphic carcinoma with a brain metastasis. ( 25566055 )
2014
50
Recurrent intussusception caused by intestinal metastasis of pulmonary pleomorphic carcinoma. ( 24924845 )
2014

Variations for Pleomorphic Carcinoma

Expression for Pleomorphic Carcinoma

Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for Pleomorphic Carcinoma

Pathways related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.81 EGFR TP53 ZEB1
2 10.96 EGFR TP53
3 10.5 KRT8 TP53
4 10.14 EGFR TP53

GO Terms for Pleomorphic Carcinoma

Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cerebral cortex cell migration GO:0021795 9.16 EGFR NKX2-1
2 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.96 EGFR TP53
3 cell proliferation GO:0008283 8.92 ALK EGFR TP53 ZEB1

Sources for Pleomorphic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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