MCID: PLM016
MIFTS: 36

Pleomorphic Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Pleomorphic Carcinoma

MalaCards integrated aliases for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5662
NCIt 49 C4094
SNOMED-CT 67 16741004
UMLS 71 C0334233

Summaries for Pleomorphic Carcinoma

Disease Ontology : 12 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary : Pleomorphic Carcinoma is related to large cell carcinoma and soft tissue sarcoma. An important gene associated with Pleomorphic Carcinoma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are MicroRNAs in cancer and Cytoskeletal Signaling. Affiliated tissues include lung, breast and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Pleomorphic Carcinoma

Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 482)
# Related Disease Score Top Affiliating Genes
1 large cell carcinoma 30.6 NKX2-1 KRT7 KIT EGFR
2 soft tissue sarcoma 30.3 TP53 EGFR
3 benign mesothelioma 30.3 KRT7 CALB2
4 liposarcoma 30.3 VIM TP53 CALB2
5 bronchiolo-alveolar adenocarcinoma 30.2 NKX2-1 KRT7 EGFR
6 epulis 30.1 VIM PGR
7 signet ring cell adenocarcinoma 30.0 TP53 PDPN KRT7
8 neurilemmoma 29.9 VIM KIT CALB2
9 tubular adenocarcinoma 29.9 PGR KRT7 EGFR
10 lung benign neoplasm 29.9 TP53 NKX2-1 KRT7 EGFR
11 adenocarcinoma 29.9 TP53 NKX2-1 KRT7 KIT EGFR ALK
12 inflammatory breast carcinoma 29.8 PGR PDPN EGFR
13 pleomorphic liposarcoma 29.8 VIM KRT8 KIT
14 leiomyoma 29.8 VIM PGR KIT
15 kidney cancer 29.8 VIM TP53 EGFR CD274
16 lung disease 29.7 TP53 NKX2-1 EGFR CD274
17 bladder urothelial carcinoma 29.7 TP53 KRT7 KIT EGFR
18 gastrointestinal stromal tumor 29.6 VIM TP53 KIT EGFR
19 pneumothorax 29.6 VIM PGR NKX2-1 CALB2 ALK
20 rhabdomyosarcoma 29.6 VIM TP53 KIT EGFR ALK
21 fibrosarcoma 29.6 VIM TP53 KIT ALK
22 lymphoepithelioma-like carcinoma 29.6 KRT8 KRT7 KRT18 CD274
23 mesothelioma, malignant 29.5 VIM PDPN NKX2-1 KRT7 CALB2
24 small cell cancer of the lung 29.0 TP53 NKX2-1 KRT7 KRT18 KIT EGFR
25 spindle cell carcinoma 29.0 VIM PGR KRT8 KRT7 KRT18 KRT14
26 basaloid squamous cell carcinoma 29.0 TP53 KRT8 KRT7 KRT14 EGFR
27 carcinosarcoma 28.8 VIM TP53 PGR KRT7 KIT EGFR
28 small cell carcinoma 28.6 TP53 NKX2-1 KRT8 KRT7 KRT18 KIT
29 in situ carcinoma 28.5 TP53 PGR PDPN KRT8 KRT14 EGFR
30 mucinous adenocarcinoma 28.3 VIM TP53 PGR NKX2-1 KRT7 KIT
31 ductal carcinoma in situ 28.2 TP53 PGR KRT8 KRT18 KRT14 EGFR
32 adenosquamous carcinoma 28.0 TP53 PGR NKX2-1 KRT8 KRT7 KRT18
33 lung cancer susceptibility 3 27.1 ZEB1 TP53 NKX2-1 KRT8 KRT7 KRT18
34 lung cancer 26.6 ZEB1 TP53 PGR NKX2-1 KRT8 KRT7
35 breast cancer 25.3 ZEB1 VIM TP53 PGR PDPN NKX2-1
36 recurrent respiratory papillomatosis 10.6 EGFR CD274
37 signet ring lung adenocarcinoma 10.5 EGFR ALK
38 ureter adenocarcinoma 10.5 NKX2-1 KRT7
39 small cell carcinoma of the bladder 10.5 NKX2-1 KRT7
40 cystadenofibroma 10.5 KRT7 CALB2
41 solid adenocarcinoma with mucin production 10.5 NKX2-1 KRT7
42 mucinous lung adenocarcinoma 10.5 NKX2-1 EGFR
43 orbital lymphangioma 10.5 PDPN EGFR
44 gynandroblastoma 10.5 VIM CALB2
45 esophagus verrucous carcinoma 10.5 TP53 EGFR
46 malignant spiradenoma 10.5 TP53 KRT7
47 heart lymphoma 10.5 VIM ALK
48 pancreatic foamy gland adenocarcinoma 10.5 TP53 KRT7
49 papillary squamous carcinoma 10.5 KRT7 EGFR
50 epididymal neoplasm 10.5 KRT7 CALB2

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to Pleomorphic Carcinoma

Symptoms & Phenotypes for Pleomorphic Carcinoma

GenomeRNAi Phenotypes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

26 (show all 36)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.95 SLC7A5
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.95 VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.95 SLC7A5
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.95 EGFR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.95 TP53
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.95 TP53
7 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.95 EGFR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.95 TP53
9 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.95 SLC7A5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.95 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.95 SLC7A5
12 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.95 SLC7A5
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.95 SLC7A5 TP53
14 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.95 VIM
15 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.95 SLC7A5 VIM
16 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.95 VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.95 TP53
18 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.95 EGFR SLC7A5 TP53 VIM
19 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.95 SLC7A5
20 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.95 EGFR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.95 EGFR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.95 SLC7A5
23 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.95 VIM
24 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.95 VIM
25 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.95 TP53
26 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.95 TP53
27 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.95 SLC7A5
28 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.95 SLC7A5
29 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.95 EGFR
30 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.95 SLC7A5
31 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.95 SLC7A5
32 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.95 VIM
33 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.95 SLC7A5
34 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.95 SLC7A5
35 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.95 EGFR VIM
36 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.95 SLC7A5

MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.32 ALK CALB2 CD274 KIT NKX2-1 PDPN
2 homeostasis/metabolism MP:0005376 10.32 ALK CD274 EGFR KIT KRT14 KRT7
3 cellular MP:0005384 10.26 CD274 EGFR KIT KRT14 KRT7 NKX2-1
4 mortality/aging MP:0010768 10.25 ALK CD274 EGFR KIT KRT14 KRT18
5 cardiovascular system MP:0005385 10.22 EGFR KIT KRT8 NKX2-1 PDPN PGR
6 hematopoietic system MP:0005397 10.19 CD274 EGFR KIT KRT14 KRT8 PDPN
7 immune system MP:0005387 10.16 CD274 EGFR KIT KRT14 KRT8 PDPN
8 digestive/alimentary MP:0005381 10.15 EGFR KIT KRT14 KRT8 NKX2-1 PDPN
9 embryo MP:0005380 10.14 EGFR KIT KRT18 KRT8 PGR TP53
10 endocrine/exocrine gland MP:0005379 10.13 ALK EGFR KIT KRT14 NKX2-1 PGR
11 integument MP:0010771 10.09 ALK CD274 EGFR KIT KRT14 PDPN
12 hearing/vestibular/ear MP:0005377 9.99 EGFR KIT KRT14 KRT8 TP53 ZEB1
13 neoplasm MP:0002006 9.92 ALK EGFR KIT KRT14 NKX2-1 PGR
14 muscle MP:0005369 9.91 EGFR KIT PDPN PGR TP53 VIM
15 reproductive system MP:0005389 9.85 ALK EGFR KIT KRT14 KRT8 NKX2-1
16 pigmentation MP:0001186 9.73 ALK EGFR KIT KRT14 TP53 ZEB1
17 respiratory system MP:0005388 9.61 ALK EGFR KIT KRT14 NKX2-1 PDPN
18 skeleton MP:0005390 9.32 ALK CD274 EGFR KIT NKX2-1 PDPN

Drugs & Therapeutics for Pleomorphic Carcinoma

Search Clinical Trials , NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

Anatomical Context for Pleomorphic Carcinoma

MalaCards organs/tissues related to Pleomorphic Carcinoma:

40
Lung, Breast, Thyroid, Pancreas, Thymus, Skin, Liver

Publications for Pleomorphic Carcinoma

Articles related to Pleomorphic Carcinoma:

(show top 50) (show all 335)
# Title Authors PMID Year
1
Prognostic Significance of Glucose Metabolism as GLUT1 in Patients with Pulmonary Pleomorphic Carcinoma. 61
32028659 2020
2
Prognostic Significance of Tumor Immunity in Surgically Resected Pulmonary Pleomorphic Carcinoma. 61
31892575 2020
3
A case of resected primary pulmonary pleomorphic carcinoma with long-term survival after multidisciplinary treatment. 61
31993853 2020
4
Trousseau's syndrome associated with pulmonary pleomorphic carcinoma exhibiting aggressive features: A case report. 61
31814975 2020
5
EGFR mutation genotyping and ALK status determination in liquid-based cytology samples of non-small cell lung cancer. 61
31823000 2019
6
Impressive response to nivolumab of non-small-cell lung cancer containing sarcomatoid components. 61
31452896 2019
7
Impact of Histopathologic Changes Induced by Polyethylene Glycol Hydrogel Pleural Sealants Used During Transthoracic Biopsy on Lung Cancer Resection Specimen Staging. 61
31577551 2019
8
Clinicopathological Features, Surgical Outcomes, Oncogenic Status and PD-L1 Expression of Pulmonary Pleomorphic Carcinoma. 61
31570483 2019
9
Clinical Significance of Various Drug-Sensitivity Markers in Patients with Surgically Resected Pulmonary Pleomorphic Carcinoma. 61
31653009 2019
10
Could Tumor Spread Through Air Spaces Identify Distinct Subgroup With Poor Prognosis in Lung Pleomorphic Carcinoma? 61
31511154 2019
11
Cytological Evaluation of Pleomorphic Carcinoma of the Lung. 61
31165583 2019
12
Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis. 61
30914285 2019
13
Commentary: Pleomorphic carcinoma: An aggressive type of non-small cell lung cancer that should be treated like the others. 61
31196757 2019
14
Perioperative chemotherapy is not associated with improved survival in stage I pleomorphic lung cancer. 61
31122617 2019
15
Two Cases of Pleomorphic Carcinoma of the Lung Presenting as a Subsolid Mass due to Extensive Peritumoral Hemorrhage. 61
31409506 2019
16
Pleomorphic carcinoma of the lung: from thin-walled cavity to solid tumor. 61
31355240 2019
17
Next-Generation Sequencer Analysis of Pulmonary Pleomorphic Carcinoma With a CD74-ROS1 Fusion Successfully Treated With Crizotinib. 61
31027745 2019
18
Dramatic response to nivolumab after local radiotherapy in pulmonary pleomorphic carcinoma with rapid progressive post-surgical recurrence. 61
30860657 2019
19
A High PD-L1 Expression in Pulmonary Pleomorphic Carcinoma Correlates with Parietal-pleural Invasion and Might Predict a Poor Prognosis. 61
30568128 2019
20
Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report. 61
30944043 2019
21
Rapid and Long-term Response of Pulmonary Pleomorphic Carcinoma to Nivolumab. 61
30568113 2019
22
Spread Through Air Spaces (STAS): A New Pathologic Morphology in Lung Cancer. 61
30482593 2019
23
A rare presentation of pleomorphic carcinoma of lung mimic empyema. 61
30906756 2019
24
Expression of amino acid transporter (LAT1 and 4F2hc) in pulmonary pleomorphic carcinoma. 61
30300664 2019
25
Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma. 61
31249776 2019
26
Prognostic Impact of β2 Adrenergic Receptor Expression in Surgically Resected Pulmonary Pleomorphic Carcinoma. 61
30591486 2019
27
Approaches to Tumor Classification in Pulmonary Sarcomatoid Carcinoma. 61
31824199 2019
28
Pulmonary Sarcomatoid carcinoma: a surgical diagnosis and prognostic factors. 61
31535704 2019
29
[Current Status of Diagnosis and Treatment of Pulmonary Sarcomatoid Carcinoma]. 61
30591097 2018
30
[A Case of Pancreatic Metastasis from Pulmonary Pleomorphic Carcinoma]. 61
30692293 2018
31
Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis. 61
30364514 2018
32
Effective combined therapy with ramucirumab for advanced pulmonary pleomorphic carcinoma. 61
30275953 2018
33
Tumor Spread Through Air Spaces Identifies a Distinct Subgroup With Poor Prognosis in Surgically Resected Lung Pleomorphic Carcinoma. 61
29932891 2018
34
Pleomorphic carcinoma of the lung mimicking synchronous pulmonary adenocarcinoma and small bowel sarcoma. 61
30416598 2018
35
Characteristics and Outcome of ROS1-Positive Non-Small Cell Lung Cancer Patients in Routine Clinical Practice. 61
29883837 2018
36
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving pancreas: an institution's experience. 61
31043285 2018
37
Nivolumab-induced Limbic Encephalitis with Anti-Hu Antibody in a Patient With Advanced Pleomorphic Carcinoma of the Lung. 61
29857970 2018
38
What's in a giant cell? A case of metastatic sarcomatoid pleomorphic carcinoma with osteoclast-like giant cells involving the thyroid. 61
29473224 2018
39
Efficacy of mesna, doxorubicin, ifosfamide, and dacarbazine (MAID) in patients with advanced pulmonary pleomorphic carcinoma. 61
30032825 2018
40
Uncommon Types of Lung Carcinoma With Mixed Histology: Sarcomatoid Carcinoma, Adenosquamous Carcinoma, and Mucoepidermoid Carcinoma. 61
30040455 2018
41
Anaplastic lymphoma kinase (ALK)-rearranged pulmonary pleomorphic carcinoma successfully treated with crizotinib. 61
29310482 2018
42
Clinicopathological characteristics and prognosis of pulmonary pleomorphic carcinoma: a population-based retrospective study using SEER data. 61
30174872 2018
43
Clinical and molecular characteristics of pulmonary sarcomatoid carcinoma. 61
29458244 2018
44
Granulocyte colony stimulating factor-producing lung cancer with severe anemia of inflammation. 61
29594877 2018
45
Pulmonary pleomorphic carcinoma with pseudoprogression during nivolumab therapy and the usefulness of tumor markers: A case report. 61
29988633 2018
46
Pulmonary pleomorphic carcinoma: A case harboring EGFR mutation treated with EGFR-TKIs. 61
29675860 2018
47
Multiregion gene expression profiling reveals heterogeneity in molecular subtypes and immunotherapy response signatures in lung cancer. 61
29410488 2018
48
Air bronchogram in pleomorphic carcinoma of the lung is associated with favorable prognosis. 61
29624900 2018
49
Programmed death-ligand 1 (PD-L1) expression in pleomorphic carcinoma of the lung. 61
29601633 2018
50
Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report. 61
29928213 2018

Variations for Pleomorphic Carcinoma

Expression for Pleomorphic Carcinoma

Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for Pleomorphic Carcinoma

Pathways related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.11 ZEB1 VIM TP53 EGFR
2 12.04 VIM PDPN KRT8 KRT7 KRT18
3
Show member pathways
12.01 KRT8 KRT7 KRT18 KRT14
4 11.6 ZEB1 VIM TP53
5 11.1 TP53 SLC7A5 KIT EGFR
6
Show member pathways
11.05 VIM KRT8 KRT7 KRT18 KRT14

GO Terms for Pleomorphic Carcinoma

Cellular components related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10.06 ZEB1 VIM TP53 SLC7A5 PGR PDPN
2 extracellular exosome GO:0070062 9.86 VIM SLC7A5 KRT8 KRT7 KRT18 KRT14
3 nuclear matrix GO:0016363 9.54 VIM TP53 KRT8
4 cell periphery GO:0071944 9.33 KRT8 KRT18 KRT14
5 keratin filament GO:0045095 9.26 KRT8 KRT7 KRT18 KRT14
6 intermediate filament GO:0005882 9.02 VIM KRT8 KRT7 KRT18 KRT14

Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.78 ZEB1 VIM TP53 KIT
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.69 KIT EGFR ALK
3 lung development GO:0030324 9.67 PDPN NKX2-1 EGFR
4 viral process GO:0016032 9.65 VIM TP53 KRT8 KRT7 KRT18
5 positive regulation of cell migration GO:0030335 9.62 PDPN KIT EGFR CD274
6 tongue development GO:0043586 9.46 KIT EGFR
7 regulation of cell proliferation GO:0042127 9.46 TP53 KIT EGFR ALK
8 hepatocyte apoptotic process GO:0097284 9.43 KRT8 KRT18
9 cerebral cortex cell migration GO:0021795 9.4 NKX2-1 EGFR
10 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.37 TP53 EGFR
11 keratinization GO:0031424 9.26 KRT8 KRT7 KRT18 KRT14
12 cornification GO:0070268 8.92 KRT8 KRT7 KRT18 KRT14

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 ZEB1 VIM TP53 SLC7A5 PGR PDPN
2 keratin filament binding GO:1990254 9.16 VIM KRT14
3 scaffold protein binding GO:0097110 9.13 VIM KRT8 KRT18
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 KIT EGFR ALK

Sources for Pleomorphic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....