MCID: PLM016
MIFTS: 36

Pleomorphic Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Pleomorphic Carcinoma

MalaCards integrated aliases for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5662
NCIt 51 C4094
SNOMED-CT 69 16741004
UMLS 74 C0334233

Summaries for Pleomorphic Carcinoma

Disease Ontology : 12 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary : Pleomorphic Carcinoma is related to intestinal perforation and adenocarcinoma. An important gene associated with Pleomorphic Carcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Keratinization and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include pancreas, brain and thyroid, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Pleomorphic Carcinoma

Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 intestinal perforation 30.3 KRT7 NKX2-1
2 adenocarcinoma 30.2 ALK EGFR TP53
3 large cell carcinoma 30.1 EGFR KRT7 NKX2-1
4 small cell carcinoma 29.4 EGFR KRT7 NKX2-1 TP53
5 lung cancer 28.5 ALK CD274 EGFR KRT18 KRT7 NKX2-1
6 benign breast adenomyoepithelioma 10.4 EGFR KRT7
7 oncocytic breast carcinoma 10.4 EGFR KRT7
8 solid adenocarcinoma with mucin production 10.3 KRT7 NKX2-1
9 ovarian germ cell teratoma 10.3 KRT7 NKX2-1
10 lung acinar adenocarcinoma 10.3 KRT7 NKX2-1
11 anal canal adenocarcinoma 10.3 CD274 KRT7
12 small cell carcinoma of the bladder 10.3 KRT7 NKX2-1
13 ovarian germ cell cancer 10.3 KRT7 NKX2-1
14 papillary adenoma 10.3 KRT7 NKX2-1
15 giant cell glioblastoma 10.3 EGFR TP53
16 cervical adenosquamous carcinoma 10.3 EGFR KRT7
17 breast carcinoma in situ 10.3 EGFR TP53
18 pulmonary sclerosing hemangioma 10.3 KRT7 NKX2-1
19 sclerosing hemangioma 10.3 KRT7 NKX2-1
20 ovarian clear cell carcinoma 10.3 KRT7 TP53
21 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT7 NKX2-1
22 alveoli adenoma 10.3 KRT7 NKX2-1
23 brain ependymoma 10.3 EGFR TP53
24 central nervous system lymphoma 10.3 CD274 TP53
25 recurrent respiratory papillomatosis 10.3 EGFR TP53
26 malignant spiradenoma 10.2 KRT7 TP53
27 spiradenoma 10.2 KRT7 TP53
28 breast squamous cell carcinoma 10.2 EGFR TP53
29 vulvar intraepithelial neoplasia 10.2 KRT7 TP53
30 ovarian cystic teratoma 10.2 KRT7 NKX2-1
31 epithelioid trophoblastic tumor 10.2 KRT18 KRT7
32 bladder carcinoma in situ 10.2 KRT7 TP53
33 vulvar disease 10.2 KRT7 TP53
34 lung adenoid cystic carcinoma 10.2 ALK NKX2-1
35 nasal cavity adenocarcinoma 10.2 KRT7 TP53
36 female reproductive endometrioid cancer 10.2 KRT7 TP53
37 mucinous lung adenocarcinoma 10.2 ALK EGFR
38 seminal vesicle tumor 10.2 KRT18 KRT7
39 glycogen-rich clear cell breast carcinoma 10.2 KRT7 TP53
40 gliomatosis cerebri 10.2 EGFR TP53
41 metanephric adenoma 10.2 KRT18 KRT7
42 soft tissue sarcoma 10.2 EGFR TP53
43 lymphoepithelioma-like thymic carcinoma 10.2 CD274 KRT18
44 warthin tumor 10.2 KRT18 KRT7
45 biliary papillomatosis 10.2 KRT7 TP53
46 colloid adenoma 10.2 NKX2-1 TP53
47 esophageal basaloid squamous cell carcinoma 10.2 EGFR TP53
48 alk-negative anaplastic large cell lymphoma 10.2 ALK CD274
49 endocervical adenocarcinoma 10.2 KRT7 TP53
50 eccrine sweat gland neoplasm 10.2 KRT7 TP53

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to Pleomorphic Carcinoma

Symptoms & Phenotypes for Pleomorphic Carcinoma

GenomeRNAi Phenotypes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.4 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.4 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.4 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.4 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.4 KRT8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.4 KRT18 KRT7 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.4 KRT18
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.4 KRT7

MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.01 ALK CD274 EGFR KRT7 KRT8 NKX2-1
2 growth/size/body region MP:0005378 9.98 ALK EGFR KRT18 KRT8 NKX2-1 TP53
3 mortality/aging MP:0010768 9.97 ALK CD274 EGFR KRT18 KRT8 NKX2-1
4 digestive/alimentary MP:0005381 9.85 EGFR KRT8 NKX2-1 TP53 ZEB1
5 neoplasm MP:0002006 9.72 ALK EGFR NKX2-1 TP53 ZEB1
6 reproductive system MP:0005389 9.63 ALK EGFR KRT8 NKX2-1 TP53 ZEB1
7 pigmentation MP:0001186 9.56 ALK EGFR TP53 ZEB1
8 respiratory system MP:0005388 9.35 ALK EGFR NKX2-1 TP53 ZEB1
9 skeleton MP:0005390 9.1 ALK CD274 EGFR NKX2-1 TP53 ZEB1

Drugs & Therapeutics for Pleomorphic Carcinoma

Search Clinical Trials , NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

Anatomical Context for Pleomorphic Carcinoma

MalaCards organs/tissues related to Pleomorphic Carcinoma:

42
Pancreas, Brain, Thyroid, Bone, Ovary, Thymus, Colon

Publications for Pleomorphic Carcinoma

Articles related to Pleomorphic Carcinoma:

(show top 50) (show all 152)
# Title Authors Year
1
Expression of amino acid transporter (LAT1 and 4F2hc) in pulmonary pleomorphic carcinoma. ( 30300664 )
2019
2
Rapid and Long-term Response of Pulmonary Pleomorphic Carcinoma to Nivolumab. ( 30568113 )
2019
3
A High PD-L1 Expression in Pulmonary Pleomorphic Carcinoma Correlates with Parietal-pleural Invasion and Might Predict a Poor Prognosis. ( 30568128 )
2019
4
Prognostic Impact of β2 Adrenergic Receptor Expression in Surgically Resected Pulmonary Pleomorphic Carcinoma. ( 30591486 )
2019
5
Dramatic response to nivolumab after local radiotherapy in pulmonary pleomorphic carcinoma with rapid progressive post-surgical recurrence. ( 30860657 )
2019
6
A rare presentation of pleomorphic carcinoma of lung mimic empyema. ( 30906756 )
2019
7
Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report. ( 30944043 )
2019
8
Next-Generation Sequencer Analysis of Pulmonary Pleomorphic Carcinoma With a CD74-ROS1 Fusion Successfully Treated With Crizotinib. ( 31027745 )
2019
9
Pleomorphic carcinoma of the lung mimicking synchronous pulmonary adenocarcinoma and small bowel sarcoma. ( 30416598 )
2018
10
Nivolumab-induced Limbic Encephalitis with Anti-Hu Antibody in a Patient With Advanced Pleomorphic Carcinoma of the Lung. ( 29857970 )
2018
11
Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis. ( 30364514 )
2018
12
Pulmonary pleomorphic carcinoma with few PD-1-positive immune cells and regulatory T cells that showed a complete response to nivolumab. ( 29131510 )
2018
13
Anaplastic lymphoma kinase (ALK)-rearranged pulmonary pleomorphic carcinoma successfully treated with crizotinib. ( 29310482 )
2018
14
An unusual case of duodenal metastasis of pulmonary pleomorphic carcinoma. ( 29391323 )
2018
15
What's in a giant cell? A case of metastatic sarcomatoid pleomorphic carcinoma with osteoclast-like giant cells involving the thyroid. ( 29473224 )
2018
16
Programmed death-ligand 1 (PD-L1) expression in pleomorphic carcinoma of the lung. ( 29601633 )
2018
17
Air bronchogram in pleomorphic carcinoma of the lung is associated with favorable prognosis. ( 29624900 )
2018
18
Pulmonary pleomorphic carcinoma: A case harboring EGFR mutation treated with EGFR-TKIs. ( 29675860 )
2018
19
Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report. ( 29928213 )
2018
20
Tumor Spread Through Air Spaces Identifies a Distinct Subgroup With Poor Prognosis in Surgically Resected Lung Pleomorphic Carcinoma. ( 29932891 )
2018
21
Pulmonary pleomorphic carcinoma with pseudoprogression during nivolumab therapy and the usefulness of tumor markers: A case report. ( 29988633 )
2018
22
Efficacy of mesna, doxorubicin, ifosfamide, and dacarbazine (MAID) in patients with advanced pulmonary pleomorphic carcinoma. ( 30032825 )
2018
23
A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition. ( 30112272 )
2018
24
Clinicopathological characteristics and prognosis of pulmonary pleomorphic carcinoma: a population-based retrospective study using SEER data. ( 30174872 )
2018
25
Effective combined therapy with ramucirumab for advanced pulmonary pleomorphic carcinoma. ( 30275953 )
2018
26
Breast metastasis of pulmonary pleomorphic carcinoma: a case report. ( 28188513 )
2017
27
Stage IV pleomorphic carcinoma of the lung without recurrence for 6 years: a case report. ( 28224563 )
2017
28
Clinicopathological factors influenced the prognosis of surgically resected pulmonary pleomorphic carcinoma. ( 28616281 )
2017
29
Diffuse fluorodeoxyglucose-positron uptake in the bone marrow of a patient with granulocyte colony-stimulating factor-producing pleomorphic carcinoma of the lung: A case report. ( 28685085 )
2017
30
Pulmonary pleomorphic carcinoma: A case report and review of the literature. ( 28723756 )
2017
31
Marked response to pembrolizumab in a patient with pulmonary pleomorphic carcinoma highly positive for PD-L1. ( 28754417 )
2017
32
The Successful Treatment of Pulmonary Pleomorphic Carcinoma with Pembrolizumab: A Case Report. ( 28878661 )
2017
33
Atrial Involvement in Pleomorphic Carcinoma of the Lung. ( 28883256 )
2017
34
Nivolumab-Induced Acute Diabetes Mellitus and Hypophysitis in a Patient with Advanced Pulmonary Pleomorphic Carcinoma with a Prolonged Tumor Response. ( 29074210 )
2017
35
Successful Resection of G719X-Positive Pleomorphic Carcinoma after Afatinib Treatment. ( 29515394 )
2017
36
Clinicoradiological outcomes of 33 cases of surgically resected pulmonary pleomorphic carcinoma: correlation with prognostic indicators. ( 25994197 )
2016
37
Pemetrexed and bevacizumab-containing chemotherapy for pleomorphic carcinoma of the lung. ( 27073676 )
2016
38
High co-expression of PD-L1 and HIF-1α correlates with tumour necrosis in pulmonary pleomorphic carcinoma. ( 27107327 )
2016
39
Pleomorphic Carcinoma of the Lung: Relationship Between CT Findings and Prognosis. ( 27144416 )
2016
40
"Pseudoprogression" of Pulmonary Pleomorphic Carcinoma during Nivolumab Therapy. ( 27189927 )
2016
41
Pleomorphic Carcinoma of the Colon: Morphological and Immunohistochemical Findings. ( 27462191 )
2016
42
A rare primary pulmonary tumor with difficult diagnosis: pleomorphic carcinoma. ( 27525610 )
2016
43
Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung. ( 24846683 )
2016
44
P1.27: A Clinicopathological Study of Resected Pulmonary Pleomorphic Carcinoma: Track: Advanced NSCLC. ( 27676513 )
2016
45
Frequent loss of the expression of multiple subunits of the SWI/SNF complex in large cell carcinoma and pleomorphic carcinoma of the lung. ( 26345631 )
2015
46
Sarcomatous Components May Predict Prognosis in Patients with Pulmonary Pleomorphic Carcinoma. ( 25423314 )
2015
47
Clinicopathological analysis of pleomorphic carcinoma of the lung: diffuse ZEB1 expression predicts poor survival. ( 25479687 )
2015
48
Comparative analysis of tumor angiogenesis and clinical features of 55 cases of pleomorphic carcinoma and adenocarcinoma of the lung. ( 25550577 )
2015
49
Response to Crizotinib and Clinical Outcome in ALK-Rearranged Pulmonary Pleomorphic Carcinoma. ( 25898961 )
2015
50
Tumor-related gene expression levels in pulmonary pleomorphic carcinoma. ( 26031756 )
2015

Variations for Pleomorphic Carcinoma

Expression for Pleomorphic Carcinoma

Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for Pleomorphic Carcinoma

Pathways related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.89 KRT18 KRT7 KRT8
2
Show member pathways
10.83 KRT18 KRT7 KRT8
3 10.7 KRT8 TP53
4 10.47 EGFR TP53

GO Terms for Pleomorphic Carcinoma

Cellular components related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.13 KRT18 KRT7 KRT8
2 keratin filament GO:0045095 8.8 KRT18 KRT7 KRT8

Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.67 KRT18 KRT7 KRT8 TP53
2 keratinization GO:0031424 9.61 KRT18 KRT7 KRT8
3 negative regulation of apoptotic process GO:0043066 9.58 EGFR KRT18 TP53
4 cornification GO:0070268 9.5 KRT18 KRT7 KRT8
5 cerebral cortex cell migration GO:0021795 9.26 EGFR NKX2-1
6 cell proliferation GO:0008283 9.26 ALK EGFR TP53 ZEB1
7 hepatocyte apoptotic process GO:0097284 9.16 KRT18 KRT8
8 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.62 EGFR TP53

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.32 KRT18

Sources for Pleomorphic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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