MCID: PLM016
MIFTS: 35

Pleomorphic Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Pleomorphic Carcinoma

MalaCards integrated aliases for Pleomorphic Carcinoma:

Name: Pleomorphic Carcinoma 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5662
NCIt 50 C4094
SNOMED-CT 68 16741004
UMLS 72 C0334233

Summaries for Pleomorphic Carcinoma

Disease Ontology : 12 A carcinoma that is consisting of spindle or giant cells (or both) combined with squamous cell carcinoma, adenocarcinoma, or large-cell carcinoma.

MalaCards based summary : Pleomorphic Carcinoma is related to large cell carcinoma and intestinal perforation. An important gene associated with Pleomorphic Carcinoma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include lung, breast and pancreas, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Pleomorphic Carcinoma

Diseases related to Pleomorphic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 large cell carcinoma 30.8 NKX2-1 KRT7 EGFR
2 intestinal perforation 30.8 NKX2-1 KRT7
3 soft tissue sarcoma 30.2 TP53 EGFR
4 bronchiolo-alveolar adenocarcinoma 30.1 NKX2-1 KRT7 EGFR
5 in situ carcinoma 30.0 TP53 EGFR
6 carcinosarcoma 29.7 TP53 KRT7 KIT
7 adenocarcinoma 29.7 TP53 KIT EGFR ALK
8 gastrointestinal stromal tumor 29.6 TP53 KIT EGFR
9 bladder urothelial carcinoma 29.5 TP53 KRT7 KIT
10 lung benign neoplasm 29.4 TP53 NKX2-1 KRT7 EGFR
11 lymphoepithelioma-like carcinoma 29.3 KRT8 KRT7 CD274
12 ductal carcinoma in situ 29.2 TP53 KRT8 EGFR
13 lung cancer susceptibility 3 29.2 TP53 NKX2-1 KRT7 EGFR ALK
14 small cell carcinoma 29.0 TP53 NKX2-1 KRT7 KIT EGFR
15 basaloid squamous cell carcinoma 28.7 TP53 KRT8 KRT7 EGFR
16 small cell cancer of the lung 28.6 TP53 NKX2-1 KRT7 KIT EGFR
17 adenosquamous carcinoma 27.8 TP53 NKX2-1 KRT8 KRT7 KIT EGFR
18 lung cancer 27.4 TP53 NKX2-1 KRT7 KIT EGFR CD274
19 benign breast adenomyoepithelioma 10.6 KRT7 EGFR
20 oncocytic breast carcinoma 10.6 KRT7 EGFR
21 ovarian germ cell teratoma 10.6 NKX2-1 KRT7
22 solid adenocarcinoma with mucin production 10.6 NKX2-1 KRT7
23 small cell carcinoma of the bladder 10.5 NKX2-1 KRT7
24 lung acinar adenocarcinoma 10.5 NKX2-1 KRT7
25 ovarian germ cell cancer 10.5 NKX2-1 KRT7
26 papillary adenoma 10.5 NKX2-1 KRT7
27 pulmonary sclerosing hemangioma 10.5 NKX2-1 KRT7
28 sclerosing hemangioma 10.5 NKX2-1 KRT7
29 alveoli adenoma 10.5 NKX2-1 KRT7
30 mucinous bronchioloalveolar adenocarcinoma 10.5 NKX2-1 KRT7
31 cervical adenosquamous carcinoma 10.5 KRT7 EGFR
32 anal canal adenocarcinoma 10.4 KRT7 CD274
33 brain ependymoma 10.4 TP53 EGFR
34 ovarian cystic teratoma 10.4 NKX2-1 KRT7
35 recurrent respiratory papillomatosis 10.4 TP53 EGFR
36 breast squamous cell carcinoma 10.4 TP53 EGFR
37 colloid adenoma 10.4 TP53 NKX2-1
38 ceruminoma 10.4 KRT7 KIT
39 microglandular adenosis 10.4 TP53 EGFR
40 malignant spiradenoma 10.4 TP53 KRT7
41 spiradenoma 10.4 TP53 KRT7
42 vulvar intraepithelial neoplasia 10.4 TP53 KRT7
43 jejunal cancer 10.4 KRT7 KIT
44 chordoid glioma 10.4 TP53 NKX2-1
45 mucinous lung adenocarcinoma 10.4 EGFR ALK
46 rete testis adenocarcinoma 10.4 NKX2-1 KIT
47 prostate small cell carcinoma 10.4 NKX2-1 KIT
48 intratubular embryonal carcinoma 10.4 KRT7 KIT
49 gliomatosis cerebri 10.4 TP53 EGFR
50 cribriform carcinoma 10.4 KRT7 KIT

Graphical network of the top 20 diseases related to Pleomorphic Carcinoma:



Diseases related to Pleomorphic Carcinoma

Symptoms & Phenotypes for Pleomorphic Carcinoma

GenomeRNAi Phenotypes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.02 KIT
2 Decreased substrate adherent cell growth GR00193-A-2 9.02 ALK EGFR KIT
3 Decreased substrate adherent cell growth GR00193-A-4 9.02 KIT

MGI Mouse Phenotypes related to Pleomorphic Carcinoma:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.11 ALK CD274 EGFR KIT KRT7 KRT8
2 growth/size/body region MP:0005378 10.04 ALK EGFR KIT KRT8 NKX2-1 TP53
3 cardiovascular system MP:0005385 10.01 EGFR KIT KRT8 NKX2-1 TP53 ZEB1
4 mortality/aging MP:0010768 10.01 ALK CD274 EGFR KIT KRT8 NKX2-1
5 digestive/alimentary MP:0005381 10 EGFR KIT KRT8 NKX2-1 TP53 ZEB1
6 endocrine/exocrine gland MP:0005379 9.99 ALK EGFR KIT NKX2-1 TP53 ZEB1
7 integument MP:0010771 9.91 ALK CD274 EGFR KIT TP53 ZEB1
8 hearing/vestibular/ear MP:0005377 9.88 EGFR KIT KRT8 TP53 ZEB1
9 neoplasm MP:0002006 9.85 ALK EGFR KIT NKX2-1 TP53 ZEB1
10 no phenotypic analysis MP:0003012 9.72 CD274 EGFR KIT NKX2-1 TP53
11 reproductive system MP:0005389 9.7 ALK EGFR KIT KRT8 NKX2-1 TP53
12 pigmentation MP:0001186 9.65 ALK EGFR KIT TP53 ZEB1
13 respiratory system MP:0005388 9.43 ALK EGFR KIT NKX2-1 TP53 ZEB1
14 skeleton MP:0005390 9.17 ALK CD274 EGFR KIT NKX2-1 TP53

Drugs & Therapeutics for Pleomorphic Carcinoma

Search Clinical Trials , NIH Clinical Center for Pleomorphic Carcinoma

Genetic Tests for Pleomorphic Carcinoma

Anatomical Context for Pleomorphic Carcinoma

MalaCards organs/tissues related to Pleomorphic Carcinoma:

41
Lung, Breast, Pancreas, Thyroid, Brain, Bone, Small Intestine

Publications for Pleomorphic Carcinoma

Articles related to Pleomorphic Carcinoma:

(show top 50) (show all 324)
# Title Authors PMID Year
1
Cytological Evaluation of Pleomorphic Carcinoma of the Lung. 38
31165583 2019
2
Two Cases of Pleomorphic Carcinoma of the Lung Presenting as a Subsolid Mass due to Extensive Peritumoral Hemorrhage. 38
31409506 2019
3
Commentary: Pleomorphic carcinoma: An aggressive type of non-small cell lung cancer that should be treated like the others. 38
31196757 2019
4
Perioperative chemotherapy is not associated with improved survival in stage I pleomorphic lung cancer. 38
31122617 2019
5
Pleomorphic carcinoma of the lung: from thin-walled cavity to solid tumor. 38
31355240 2019
6
Dramatic response to nivolumab after local radiotherapy in pulmonary pleomorphic carcinoma with rapid progressive post-surgical recurrence. 38
30860657 2019
7
Next-Generation Sequencer Analysis of Pulmonary Pleomorphic Carcinoma With a CD74-ROS1 Fusion Successfully Treated With Crizotinib. 38
31027745 2019
8
A High PD-L1 Expression in Pulmonary Pleomorphic Carcinoma Correlates with Parietal-pleural Invasion and Might Predict a Poor Prognosis. 38
30568128 2019
9
Rapid and Long-term Response of Pulmonary Pleomorphic Carcinoma to Nivolumab. 38
30568113 2019
10
Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report. 38
30944043 2019
11
Spread Through Air Spaces (STAS): A New Pathologic Morphology in Lung Cancer. 38
30482593 2019
12
Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis. 38
30914285 2019
13
A rare presentation of pleomorphic carcinoma of lung mimic empyema. 38
30906756 2019
14
Expression of amino acid transporter (LAT1 and 4F2hc) in pulmonary pleomorphic carcinoma. 38
30300664 2019
15
Prognostic Impact of β2 Adrenergic Receptor Expression in Surgically Resected Pulmonary Pleomorphic Carcinoma. 38
30591486 2019
16
Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma. 38
31249776 2019
17
[Current Status of Diagnosis and Treatment of Pulmonary Sarcomatoid Carcinoma]. 38
30591097 2018
18
[A Case of Pancreatic Metastasis from Pulmonary Pleomorphic Carcinoma]. 38
30692293 2018
19
Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis. 38
30364514 2018
20
Effective combined therapy with ramucirumab for advanced pulmonary pleomorphic carcinoma. 38
30275953 2018
21
Tumor Spread Through Air Spaces Identifies a Distinct Subgroup With Poor Prognosis in Surgically Resected Lung Pleomorphic Carcinoma. 38
29932891 2018
22
Pleomorphic carcinoma of the lung mimicking synchronous pulmonary adenocarcinoma and small bowel sarcoma. 38
30416598 2018
23
Characteristics and Outcome of ROS1-Positive Non-Small Cell Lung Cancer Patients in Routine Clinical Practice. 38
29883837 2018
24
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving pancreas: an institution's experience. 38
31043285 2018
25
Nivolumab-induced Limbic Encephalitis with Anti-Hu Antibody in a Patient With Advanced Pleomorphic Carcinoma of the Lung. 38
29857970 2018
26
Efficacy of mesna, doxorubicin, ifosfamide, and dacarbazine (MAID) in patients with advanced pulmonary pleomorphic carcinoma. 38
30032825 2018
27
Uncommon Types of Lung Carcinoma With Mixed Histology: Sarcomatoid Carcinoma, Adenosquamous Carcinoma, and Mucoepidermoid Carcinoma. 38
30040455 2018
28
Anaplastic lymphoma kinase (ALK)-rearranged pulmonary pleomorphic carcinoma successfully treated with crizotinib. 38
29310482 2018
29
What's in a giant cell? A case of metastatic sarcomatoid pleomorphic carcinoma with osteoclast-like giant cells involving the thyroid. 38
29473224 2018
30
Clinicopathological characteristics and prognosis of pulmonary pleomorphic carcinoma: a population-based retrospective study using SEER data. 38
30174872 2018
31
Clinical and molecular characteristics of pulmonary sarcomatoid carcinoma. 38
29458244 2018
32
Granulocyte colony stimulating factor-producing lung cancer with severe anemia of inflammation. 38
29594877 2018
33
Pulmonary pleomorphic carcinoma with pseudoprogression during nivolumab therapy and the usefulness of tumor markers: A case report. 38
29988633 2018
34
Multiregion gene expression profiling reveals heterogeneity in molecular subtypes and immunotherapy response signatures in lung cancer. 38
29410488 2018
35
Pulmonary pleomorphic carcinoma: A case harboring EGFR mutation treated with EGFR-TKIs. 38
29675860 2018
36
Air bronchogram in pleomorphic carcinoma of the lung is associated with favorable prognosis. 38
29624900 2018
37
Programmed death-ligand 1 (PD-L1) expression in pleomorphic carcinoma of the lung. 38
29601633 2018
38
[Pulmonary Pleomorphic Carcinoma Relapsed after Surgery Surviving Long-term by Chemotherapy and Nivolumab]. 38
29755082 2018
39
Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report. 38
29928213 2018
40
Sarcoid-Like Granulomatosis Induced by Nivolumab Treatment in a Lung Cancer Patient. 38
30186140 2018
41
Paraneoplastic autoimmune encephalitis associated with pleomorphic lung carcinoma: An autopsy case report. 38
29781194 2018
42
Concurrent combination of irradiation and immune checkpoint inhibitor for recurrent pleomorphic carcinoma of the lung. 38
31149513 2018
43
Contribution of cell blocks obtained through endobronchial ultrasound-guided transbronchial needle aspiration for the determination of lung cancer subtypes. 38
28976111 2018
44
[Clinical features and prognosis of pulmonary sarcomatoid carcinoma]. 38
29562398 2018
45
Garcin syndrome caused by sphenoid bone metastasis of lung cancer: a case study. 38
29510758 2018
46
Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography-guided fine-needle aspiration cytology. 38
29399198 2018
47
An unusual case of duodenal metastasis of pulmonary pleomorphic carcinoma. 38
29391323 2018
48
A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition. 38
30112272 2018
49
Pulmonary pleomorphic carcinoma with few PD-1-positive immune cells and regulatory T cells that showed a complete response to nivolumab. 38
29131510 2018
50
Stage IV pleomorphic carcinoma of the lung without recurrence for 6 years: a case report. 38
28224563 2017

Variations for Pleomorphic Carcinoma

Expression for Pleomorphic Carcinoma

Search GEO for disease gene expression data for Pleomorphic Carcinoma.

Pathways for Pleomorphic Carcinoma

GO Terms for Pleomorphic Carcinoma

Cellular components related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 KIT EGFR ALK

Biological processes related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.67 KIT EGFR CD274
2 peptidyl-tyrosine phosphorylation GO:0018108 9.63 KIT EGFR ALK
3 regulation of cell proliferation GO:0042127 9.61 KIT EGFR ALK
4 protein autophosphorylation GO:0046777 9.58 KIT EGFR ALK
5 cell differentiation GO:0030154 9.54 ZEB1 TP53 EGFR
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.51 KIT EGFR
7 negative regulation of apoptotic process GO:0043066 9.48 TP53 EGFR
8 cell proliferation GO:0008283 9.33 TP53 EGFR ALK
9 tongue development GO:0043586 9.32 KIT EGFR
10 cerebral cortex cell migration GO:0021795 9.26 NKX2-1 EGFR
11 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.13 KIT EGFR ALK
12 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.62 TP53 EGFR

Molecular functions related to Pleomorphic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.13 KIT EGFR ALK
2 transmembrane signaling receptor activity GO:0004888 8.85 EGFR
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 KIT EGFR ALK

Sources for Pleomorphic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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