MCID: PLM005
MIFTS: 34

Pleomorphic Lipoma

Categories: Cancer diseases

Aliases & Classifications for Pleomorphic Lipoma

MalaCards integrated aliases for Pleomorphic Lipoma:

Name: Pleomorphic Lipoma 12 15 73
Lipoma 44 73
Lipomatosis, Multiple 73
Lipoma Pleomorphic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:10192
MeSH 44 D008067
NCIt 50 C3703

Summaries for Pleomorphic Lipoma

Disease Ontology : 12 A lipoma that is characterized by floret giant cells with overlapping nuclei.

MalaCards based summary : Pleomorphic Lipoma, also known as lipoma, is related to well-differentiated liposarcoma and spindle cell lipoma. An important gene associated with Pleomorphic Lipoma is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Glioblastoma Multiforme. Affiliated tissues include tongue and adipocyte, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Pleomorphic lipomas, like spindle-cell lipomas, occur for the most part on the backs and necks of... more...

Related Diseases for Pleomorphic Lipoma

Diseases related to Pleomorphic Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 well-differentiated liposarcoma 33.1 CDK4 HMGA2 MDM2
2 spindle cell lipoma 30.8 CDK4 MDM2
3 leiomyoma 30.4 CD34 HMGA2 PGR
4 atypical lipomatous tumor 30.3 CDK4 CREB3L2 HMGA2 MDM2
5 myxoid liposarcoma 29.2 CDK4 DDIT3 HMGA2 MDM2
6 liposarcoma 28.0 CALB2 CD34 CDK4 DDIT3 HMGA2 MDM2
7 nasopalpebral lipoma-coloboma syndrome 12.3
8 ring chromosome 7 10.9 CDK4 MDM2
9 prostate stromal sarcoma 10.8 CD34 PGR
10 mesenchymoma 10.8 HMGA2 MDM2
11 trigonitis 10.8 CD34 PGR
12 undifferentiated embryonal sarcoma of the liver 10.8 CDK4 MDM2
13 vulvar dystrophy 10.8 CD34 PGR
14 lung meningioma 10.8 CD34 PGR
15 infiltrating angiolipoma 10.8 CDK4 MDM2
16 dedifferentiated liposarcoma 10.7 CDK4 HMGA2 MDM2
17 lipomatosis, multiple 10.7 CDK4 HMGA2 MDM2
18 bone osteosarcoma 10.6 CDK4 MDM2
19 leiomyosarcoma 10.6 CDK4 MDM2 PGR
20 lymphoplasmacyte-rich meningioma 10.6 CD68 PGR
21 lipoblastoma 10.6 CDK4 MDM2
22 retina lymphoma 10.6 CD34 CD68
23 meninges sarcoma 10.6 CD34 CREB3L2
24 extraosseous osteosarcoma 10.5 CD34 CDK4 MDM2
25 periosteal osteogenic sarcoma 10.5 CD34 CDK4 MDM2
26 extracutaneous mastocytoma 10.5 CD34 CD68
27 sternum cancer 10.5 CD34 CD68
28 breast angiosarcoma 10.5 CD34 PGR
29 heart sarcoma 10.5 CREB3L2 MDM2 SIK1
30 melanotic neurilemmoma 10.5 CD34 CD68
31 organ system benign neoplasm 10.5 CD34 NF1 PGR
32 malignant peripheral nerve sheath tumor 10.5 CDK4 MDM2 NF1
33 cellular schwannoma 10.5 CD34 MDM2 NF1
34 cell type cancer 10.4 CD34 CDK4 PGR
35 fibrosarcoma of bone 10.4 CDK4 CREB3L2 MDM2
36 inflammatory mfh 10.4 CD68 CDK4 MDM2
37 deep angioma 10.4 CD34 CREB3L2 PGR
38 glomeruloid hemangioma 10.4 CD34 CD68
39 intramuscular hemangioma 10.4 CD34 CREB3L2 PGR
40 hemangioma of liver 10.4 CD34 CD68
41 sarcomatoid squamous cell skin carcinoma 10.4 CD34 CD68
42 conventional leiomyosarcoma 10.4 CD68 HMGA2 NF1
43 verruciform xanthoma of skin 10.4 CD68 S100A9
44 spleen cancer 10.4 CD34 CD68
45 malignant fibrous histiocytoma of bone 10.4 CDK4 MDM2
46 plexiform schwannoma 10.3 CD34 NF1
47 inflammatory leiomyosarcoma 10.3 CD68 NF1
48 erythema elevatum diutinum 10.3 CD34 S100A9
49 reproductive organ benign neoplasm 10.3 CALB2 HMGA2 PGR
50 nodular tenosynovitis 10.2 CD68 HMGA2 S100A9

Graphical network of the top 20 diseases related to Pleomorphic Lipoma:



Diseases related to Pleomorphic Lipoma

Symptoms & Phenotypes for Pleomorphic Lipoma

MGI Mouse Phenotypes related to Pleomorphic Lipoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 CD34 CD68 CDK4 DDIT3 DNTT FCER1A
2 immune system MP:0005387 9.7 CD34 CD68 CDK4 DDIT3 DNTT FCER1A
3 neoplasm MP:0002006 9.17 CDK4 DDIT3 MDM2 NF1 PGR STAT6

Drugs & Therapeutics for Pleomorphic Lipoma

Search Clinical Trials , NIH Clinical Center for Pleomorphic Lipoma

Cochrane evidence based reviews: lipoma

Genetic Tests for Pleomorphic Lipoma

Anatomical Context for Pleomorphic Lipoma

MalaCards organs/tissues related to Pleomorphic Lipoma:

41
Tongue, Adipocyte

Publications for Pleomorphic Lipoma

Articles related to Pleomorphic Lipoma:

(show top 50) (show all 66)
# Title Authors Year
1
Atypical multivacuolated lipoblasts and atypical mitoses are not compatible with the diagnosis of spindle cell/pleomorphic lipoma. ( 29317234 )
2018
2
Atypical multivacuolated lipoblasts and atypical mitoses are not compatible with the diagnosis of spindle cell/pleomorphic lipoma-reply. ( 29320749 )
2018
3
Pleomorphic lipoma. ( 29328546 )
2018
4
Intradermal spindle cell/pleomorphic lipoma: Case report and review of the literature. ( 28984623 )
2017
5
Fat Free Pleomorphic Lipoma of Oral Cavity: A Rare Entity. ( 28511518 )
2017
6
Combined classical spindle cell/pleomorphic lipoma spectrum imaging and clinical data. ( 28823067 )
2017
7
Pleomorphic Lipoma of the Neck in an Infant: A Rare Clinical Entity. ( 28694582 )
2017
8
Uncommon Tumor, Uncommon Location: A Dermal-Based Spindle Cell/Pleomorphic Lipoma. ( 26913848 )
2016
9
Pleomorphic lipoma: A gentle giant of pathology. ( 26729985 )
2015
10
Unilateral Pleomorphic Lipoma of the Eyebrow. ( 27172296 )
2015
11
A rare case of neurofibroma with lipomatous differentiation and floret like giant cells-cytologically disguising as pleomorphic lipoma. ( 24943788 )
2014
12
Retropharyngeal spindle cell/pleomorphic lipoma. ( 23690719 )
2013
13
Pleomorphic lipoma of the tongue as potential mimic of liposarcoma. ( 23723609 )
2013
14
A case of 'fat-free' pleomorphic lipoma occurring in the upper back and axilla simultaneously. ( 23786924 )
2013
15
Diplopia from pleomorphic lipoma of the orbit with lateral rectus muscle involvement. ( 23328779 )
2013
16
Pleomorphic lipoma lacking mature fat component in extensive myxoid stroma: a great diagnostic challenge. ( 23148444 )
2012
17
Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications. ( 22790852 )
2012
18
Pedunculated cutaneous spindle cell/pleomorphic lipoma. ( 19678825 )
2010
19
Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases. ( 19774616 )
2010
20
Spindle cell/pleomorphic lipoma of the oral cavity. ( 19881383 )
2009
21
Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor. ( 17255763 )
2007
22
Pleomorphic lipoma of the oral cavity. Report of a case. ( 16688109 )
2006
23
Giant pleomorphic lipoma of the neck. ( 16462377 )
2006
24
Orbital pleomorphic lipoma in a 25-year-old male. ( 16704722 )
2006
25
Pleomorphic lipoma of the face: case report. ( 16390474 )
2006
26
Fine-needle aspiration of a pleomorphic lipoma of the head and neck: a case report. ( 15637670 )
2005
27
Pleomorphic lipoma: a definite histopathological entity. ( 15510605 )
2004
28
Pleomorphic lipoma of the orbit: a case series and review of literature. ( 12511353 )
2003
29
Pleomorphic lipoma of the tonsillar fossa--a case report. ( 15025314 )
2003
30
Pleomorphic lipoma of the tongue. ( 11997788 )
2002
31
Intradermal spindle cell/pleomorphic lipoma of the vulva: case report and review of the literature. ( 11841521 )
2002
32
Atypical lipomatous tumor of the lip with pleomorphic lipoma-like myxoid area, clinically simulating mucocele. ( 12269996 )
2002
33
Benign laryngeal lesions - a clinicopathological study of eleven years and a case report of pleomorphic lipoma. ( 23119904 )
2002
34
Angiomyxolipoma shares cytogenetic changes with lipoma, spindle cell/pleomorphic lipoma and myxoma. ( 11213837 )
2001
35
Fine-needle aspiration of pleomorphic lipoma. ( 11285630 )
2001
36
Pleomorphic lipoma: case report and literature review. ( 10759828 )
2000
37
Diagnostic pitfalls in fine needle aspiration cytology of pleomorphic lipoma. A case report. ( 10934961 )
2000
38
Aspiration biopsy of pleomorphic lipoma of the breast. A case report. ( 10740617 )
2000
39
Pleomorphic lipoma with pseudopapillary structures: a pleomorphic counterpart of pseudoangiomatous spindle cell lipoma. ( 10792493 )
2000
40
Intradermal spindle cell/pleomorphic lipoma: a distinct subset. ( 11190440 )
2000
41
Myofibroblastoma of the breast with hemangiopericytoma-like pattern and pleomorphic lipoma-like areas. Report of a case with diagnostic and histogenetic considerations. ( 10337665 )
1999
42
Aspiration cytology of a pleomorphic lipoma--a cautionary note. ( 10458506 )
1999
43
Pleomorphic lipoma of the parotid gland. ( 9578889 )
1998
44
Pleomorphic lipoma on fine needle aspiration cytology. ( 9850671 )
1998
45
A case of pleomorphic lipoma of the hypopharynx. ( 9763894 )
1998
46
Pleomorphic lipoma. ( 8669539 )
1996
47
Spindle cell and pleomorphic lipoma: an ultrastructural study. ( 8597202 )
1995
48
Pleomorphic lipoma in the middle mediastinum. ( 7561568 )
1995
49
Fine needle aspiration of pleomorphic lipoma: a potential pitfall of cytodiagnosis. ( 8453018 )
1993
50
Well-differentiated liposarcoma mimicking a pleomorphic lipoma--a case report. ( 8491861 )
1993

Variations for Pleomorphic Lipoma

Expression for Pleomorphic Lipoma

Search GEO for disease gene expression data for Pleomorphic Lipoma.

Pathways for Pleomorphic Lipoma

Pathways related to Pleomorphic Lipoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 CD34 CD68 FCER1A
2 11.18 CDK4 MDM2 NF1
3 10.54 CDK4 DDIT3 NF1

GO Terms for Pleomorphic Lipoma

Cellular components related to Pleomorphic Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.47 CALB2 CDK4 CREB3L2 DDIT3 DNTT EPHB2

Biological processes related to Pleomorphic Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of long-term synaptic potentiation GO:1900271 9.16 CALB2 NF1
2 negative regulation of CREB transcription factor activity GO:0032792 8.96 DDIT3 SIK1
3 paracrine signaling GO:0038001 8.62 CD34 PGR

Molecular functions related to Pleomorphic Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.46 CREB3L2 DDIT3 HMGA2 PGR
2 cAMP response element binding GO:0035497 8.96 CREB3L2 HMGA2
3 cAMP response element binding protein binding GO:0008140 8.62 DDIT3 SIK1

Sources for Pleomorphic Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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