MCID: PLM005
MIFTS: 40

Pleomorphic Lipoma

Categories: Cancer diseases

Aliases & Classifications for Pleomorphic Lipoma

MalaCards integrated aliases for Pleomorphic Lipoma:

Name: Pleomorphic Lipoma 12 15 70
Lipoma 44 70
Lipomatosis, Multiple 70
Lipoma Pleomorphic 54

Classifications:



External Ids:

Disease Ontology 12 DOID:10192
MeSH 44 D008067
NCIt 50 C3703
SNOMED-CT 67 189783001
UMLS 70 C0023798 C0205823 C3489413

Summaries for Pleomorphic Lipoma

Disease Ontology : 12 A lipoma that is characterized by floret giant cells with overlapping nuclei.

MalaCards based summary : Pleomorphic Lipoma, also known as lipoma, is related to chondroid lipoma and lipoma of spermatic cord. An important gene associated with Pleomorphic Lipoma is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are Ovarian Infertility Genes and Oncogene Induced Senescence. The drugs Hydrocortisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include colon, spinal cord and breast, and related phenotype is neoplasm.

Wikipedia : 73 Pleomorphic lipomas, like spindle-cell lipomas, occur for the most part on the backs and necks of... more...

Related Diseases for Pleomorphic Lipoma

Diseases related to Pleomorphic Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 878)
# Related Disease Score Top Affiliating Genes
1 chondroid lipoma 32.3 HMGA2 CD68
2 lipoma of spermatic cord 32.2 MDM2 CDK4
3 angiolipoma 32.1 MDM2 CD34
4 paratesticular lipoma 31.8 MDM2 CDK4
5 infiltrating lipoma 31.2 MDM2 LHFPL6 HMGA2 CDK4 CD34
6 well-differentiated liposarcoma 30.6 TSPAN31 SERPINA3 MDM2 HMGA2 CDK4 CD34
7 leiomyoma 30.6 PGR HMGA2 CD34
8 spindle cell lipoma 30.5 MDM2 CDK4 CD34
9 lipoblastoma 30.4 MDM2 CDK4
10 fibroma 30.4 SERPINA3 CD68 CD34
11 fibrous histiocytoma 30.4 SERPINA3 CD68 CD34
12 hemangioma 30.3 PGR CD68 CD34
13 sclerosing liposarcoma 30.2 MDM2 CD34
14 chondrosarcoma 30.2 SERPINA3 MDM2 CDK4
15 spindle cell sarcoma 30.1 SERPINA3 MDM2 CD34
16 skin tag 30.0 SERPINA3 CD34
17 myoma 30.0 PGR HMGA2 CD34
18 granular cell tumor 30.0 SERPINA3 CD68
19 diffuse lipomatosis 30.0 MDM2 CDK4
20 mesenchymal cell neoplasm 29.9 SERPINA3 HMGA2 CD68 CD34
21 pigmented villonodular synovitis 29.9 SERPINA3 CD68
22 hemangiopericytoma, malignant 29.9 SERPINA3 MDM2 CD34
23 exophthalmos 29.9 CD68 CD34
24 neuroma 29.9 SERPINA3 CD68 CD34
25 cellular myxoid liposarcoma 29.8 SERPINA3 MDM2 CDK4
26 mucocele of appendix 29.8 PGR CD34
27 myxoid liposarcoma 29.8 MDM2 HMGA2 CDK4
28 cutaneous fibrous histiocytoma 29.8 SERPINA3 CD68 CD34
29 meningioma, familial 29.8 SERPINA3 PGR CD68 CD34
30 angiosarcoma 29.8 MDM2 CD68 CD34
31 myositis ossificans 29.7 MDM2 CDK4
32 inflammatory liposarcoma 29.7 MDM2 CD34
33 pseudosarcomatous fibromatosis 29.7 SERPINA3 CD68 CD34
34 malignant fibrous histiocytoma 29.7 SERPINA3 MDM2 CDK4 CD68
35 pleomorphic liposarcoma 29.7 SERPINA3 MDM2 CDK4
36 cystic lymphangioma 29.7 SERPINA3 CD34
37 lipomatosis, multiple 29.7 TSPAN31 SERPINA3 MDM2 LHFPL6 HMGA2 CDK4
38 spindle cell liposarcoma 29.6 MDM2 CDK4 CD34
39 ossifying fibroma 29.5 SERPINA3 MDM2
40 dermatofibrosarcoma protuberans 29.5 SERPINA3 HMGA2 CDK4 CD34
41 liposarcoma 29.4 TSPAN31 MDM2 HMGA2 CDK4 CD68 CD34
42 gastric liposarcoma 29.4 MDM2 CDK4 CD34
43 vascular cancer 29.4 SERPINA3 CD68 CD34
44 reticulosarcoma 29.3 SERPINA3 CD68
45 infiltrating angiolipoma 29.3 MDM2 HMGA2 CDK4 CD34
46 malignant astrocytoma 29.2 SERPINA3 MDM2 CDK4
47 connective tissue benign neoplasm 29.1 SERPINA3 MDM2 CDK4 CD68 CD34
48 malignant peripheral nerve sheath tumor 29.1 MDM2 HMGA2 CDK4 CD34
49 leiomyosarcoma 29.1 SERPINA3 PGR MDM2 HMGA2 CDK4
50 mixed liposarcoma 29.0 MDM2 LHFPL6 CDK4 CD34

Graphical network of the top 20 diseases related to Pleomorphic Lipoma:



Diseases related to Pleomorphic Lipoma

Symptoms & Phenotypes for Pleomorphic Lipoma

MGI Mouse Phenotypes related to Pleomorphic Lipoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 CD34 CDK4 MDM2 PGR RCBTB2

Drugs & Therapeutics for Pleomorphic Lipoma

Drugs for Pleomorphic Lipoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
2
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
3 Anti-Inflammatory Agents Phase 3
4 Hydrocortisone 17-butyrate 21-propionate Phase 3
5 Hydrocortisone hemisuccinate Phase 3
6
Prednisolone acetate Approved, Vet_approved Phase 1, Phase 2 52-21-1
7
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
9
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
10
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
11
Isoproterenol Approved, Investigational Phase 1, Phase 2 7683-59-2 3779
12
deoxycholic acid Approved Phase 2 83-44-3 222528
13
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
14
Cortisone Experimental Phase 1, Phase 2 53-06-5 222786
15 Neurotransmitter Agents Phase 1, Phase 2
16 Cardiotonic Agents Phase 1, Phase 2
17 Adrenergic beta-Agonists Phase 1, Phase 2
18 Pharmaceutical Solutions Phase 1, Phase 2
19 Adrenergic Agents Phase 1, Phase 2
20 Gastrointestinal Agents Phase 1, Phase 2
21 Respiratory System Agents Phase 1, Phase 2
22 Neuroprotective Agents Phase 1, Phase 2
23 Methylprednisolone Acetate Phase 1, Phase 2
24 Protective Agents Phase 1, Phase 2
25 glucocorticoids Phase 1, Phase 2
26 Hormone Antagonists Phase 1, Phase 2
27 Sympathomimetics Phase 1, Phase 2
28 Antiemetics Phase 1, Phase 2
29 Hormones Phase 1, Phase 2
30 Antineoplastic Agents, Hormonal Phase 1, Phase 2
31 Anti-Asthmatic Agents Phase 1, Phase 2
32 Adrenergic Agonists Phase 1, Phase 2
33 Bronchodilator Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Hydrocortisone Treatment for Symmetric Lipomatosis Associated With Neuropathy (SLN): an N-of-1 Study Not yet recruiting NCT04821583 Phase 3 Hydrocortisone;Placebo
2 A Pilot Study: Association of Beta-2 Adrenergic Agonist and Corticosteroid Injection in the Treatment of Lipomas Completed NCT00624416 Phase 1, Phase 2 Prednisolone synthetic cortisone and Isoproterenol together
3 A Double Blind Study to Evaluate the Safety and Efficacy of Collagenase Clostridium Histolyticum (AA4500) in the Treatment of Lipoma Completed NCT02249052 Phase 2 AA4500;placebo
4 A Dose Escalation Study Using Collagenase Clostridium Histolyticum in the Treatment of Lipoma Completed NCT01613313 Phase 2 Collagenase Clostridium Histolyticum
5 A Double Blind, Randomized, Multi-Center, Placebo-Controlled Phase 2B Clinical Trial for the Evaluation of Efficacy and Safety of RZL-012 in Subjects Having Dercum's Disease Lipomas Completed NCT04229030 Phase 2 RZL-012;Vehicle
6 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Safety and Efficacy of ATX-101 (Sodium Deoxycholate for Injection) Intralipomal Injections for the Treatment of Superficial Lipomas Completed NCT00608842 Phase 2 Deoxycholic Acid Injection;Placebo
7 Phase 1, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Sequential Dose-Escalation Study of the Pharmacokinetics, Safety, and Efficacy of ATX-101 (Sodium Deoxycholate for Injection) Intralipomal Injections for the Treatment of Superficial Lipomas Completed NCT00422188 Phase 1 Deoxycholic Acid Injection;Placebo
8 Early Screening of Breast Cancer Using Radiation-Free Pressure-Free Optical Scanning Unknown status NCT00671385
9 Insight Into Subcutaneous Adipose Tissue Disorders As Part of The TREAT Program (Treatment, Research, Education, Adipose Tissue) at the University of Arizona Unknown status NCT02838277
10 Identification of Mutations Responsible for Rare Familial Skin Diseases by Next Generation Sequencing Unknown status NCT02509650
11 Developing a Biomarker for Monitoring Clinical Outcomes in Children With Spinal Lipoma Unknown status NCT02722681
12 Ultrasound-Guided Regional Blockade for Lipoma Excision: a New Approach to an Old Technique Completed NCT02753361
13 Oral and Buccal Evaluation of Mobile Beach Workers Active, not recruiting NCT04236700

Search NIH Clinical Center for Pleomorphic Lipoma

Cochrane evidence based reviews: lipoma

Genetic Tests for Pleomorphic Lipoma

Anatomical Context for Pleomorphic Lipoma

MalaCards organs/tissues related to Pleomorphic Lipoma:

40
Colon, Spinal Cord, Breast, Tongue, Bone, Heart, Small Intestine

Publications for Pleomorphic Lipoma

Articles related to Pleomorphic Lipoma:

(show top 50) (show all 9003)
# Title Authors PMID Year
1
Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies. 54 61
15618963 2005
2
Well-differentiated liposarcoma of the spermatic cord: A case report. 61
33643848 2021
3
Dermoid cyst in the subcutaneous tissues of the back: A rare case with multimodal imaging and pathologic correlation. 61
33732406 2021
4
Sonographic appearance of a large lipoma of the spermatic cord presenting clinically as an inguinoscrotal hernia. 61
32914871 2021
5
Invasive cardiac lipoma diagnosis based on echocardiography: Case report and literature review. 61
32748428 2021
6
Image-Guided Core Needle Biopsy of Adipocytic Tumors: Diagnostic Accuracy and Concordance With Final Surgical Pathology. 61
33624523 2021
7
Diagnostic and management challenges for MDM2-, CDK4-negative fatty tumors of the retroperitoneum. 61
33550433 2021
8
[Giant lipomas or retroperitoneal liposarcomas? Controversies in their diagnosis and treatment]. 61
33726894 2021
9
Surgical management of spinal "Subpial" lipomas. 61
33775334 2021
10
Forkhead box D1 promotes EMT and chemoresistance by upregulating lncRNA CYTOR in oral squamous cell carcinoma. 61
33352248 2021
11
Intraosseous lipomas originating from simple bone cysts. 61
33005976 2021
12
Large Pancreatic Lipoma Causing Duodenal Obstruction. 61
32779086 2021
13
Nasopharyngeal Lipoma: Clinical Case. 61
32780873 2021
14
Parvalbumin immunohistochemical expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney. 61
32524185 2021
15
Ileocolic intussusception caused by mass-forming fibro-granulation from healed ulcer masquerading as small bowel lipoma. 61
33405177 2021
16
Early de-tethering: analysis of urological and clinical consequences in a series of 40 children. 61
32728933 2021
17
Neuropsychological profiles in children and young adults with spina bifida. 61
33709156 2021
18
Myopericytoma in right inguinal region: A rare case report from Nepal. 61
33774449 2021
19
Open Curettage With Bone Augmentation for Symptomatic Tumors and Tumor-like Lesions of Calcaneus: A Comparison of Bioactive Glass Versus Allogeneic Bone. 61
33781640 2021
20
Aesthetic Consideration in a Patient With Lipomatosis. 61
33705070 2021
21
The Rapidly Expanding Group of RB1-Deleted Soft Tissue Tumors: An Updated Review. 61
33802620 2021
22
Tethered spinal cord syndrome in adults in the MRI era: recognition, pathology, and long-term objective outcomes. 61
33740756 2021
23
Prenatal Imaging Features and Postnatal Outcome of Short Corpus Callosum: A Series of 42 Cases. 61
33684914 2021
24
Endoscopic resection of a large submucosal tumor causing intermittent gastric outlet obstruction using a novel radiofrequency enabled device. 61
33721864 2021
25
Colo-colic intussusception secondary to colon lipoma: A case report. 61
33721822 2021
26
Ileocolic intussusception due to intestinal lipoma in an adult patient. 61
33768881 2021
27
Laparoscopic Resection of an Acute Rectosigmoid Intussusception Due to a Giant Pedunculated Lipoma. 61
33717770 2021
28
Carpal tunnel syndrome caused by a giant lipoma of the hand: A case report. 61
33631649 2021
29
Prenatal Diagnosis of Acromelic Frontonasal Dysostosis. 61
33776626 2021
30
Coexistence of three nevus lipomatosus cutaneus superficialis with typical, cutaneous adenolipoma-like, and dermal spindle cell lipoma-like histopathological features in a patient. 61
33713046 2021
31
Axillary giant lipoma opening to the skin surface: A unique presentation mimicking accessory breast. 61
33559284 2021
32
Atypical advanced interatrial block due to giant atrial lipoma. 61
33675233 2021
33
Hip Pain Secondary to Intermuscular Lipoma. 61
31445871 2021
34
Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity. 61
33235355 2021
35
A dermoid cyst misdiagnosed as a lipoma due to atypical magnetic resonance images: a case report. 61
33648548 2021
36
Therapeutic potential of small extracellular vesicles derived from lipoma tissue in adipose tissue regeneration-an in vitro and in vivo study. 61
33789709 2021
37
Endobronchial lipoma with tracheobronchial aspergillosis: A case report. 61
33725932 2021
38
Pericallosal lipoma associated with azygos-type anterior cerebral artery. 61
33715886 2021
39
Corpus callosal lipoma in a young adult with extracranial extension, presenting as a frontal scalp swelling: A rare case report. 61
33384751 2021
40
Modified endoscopic unroofing enucleation using nylon ring traction for a large gastric lipoma. 61
33368688 2021
41
Curvilinear pericallosal lipomas diagnosed incidentally during evaluation following trauma with corpus callosum abnormalities in two patients. 61
33614116 2021
42
Effect of Tranexamic Acid Administration on Postoperative Ecchymosis and Edema in Excision of Lipomas. 61
33625153 2021
43
Frequent activating PIK3CA mutations in sporadic angiolipoma. 61
32662895 2021
44
Sialolipomas of minor salivary glands: A multi-institutional study and literature review. 61
33187016 2021
45
Analysis of missed diagnosis of gastric lipomas by CT. 61
33632107 2021
46
Cerebellopontine Angle and Internal Auditory Canal Lipomas: Case Series and Systematic Review. 61
33567134 2021
47
Intramuscular abdominal hibernoma: case report of a rare tumour and a review of the literature. 61
33732418 2021
48
Comparison of Non-Operative Mesotherapy and Surgery in the Management of Superficial Lipomas. 61
33679220 2021
49
Incomplete Ileocecal Bypass for Ileal Pathology in Horses: 21 Cases (2012-2019). 61
33562529 2021
50
Medical services provided on the 'Harmonious Mission-2017' Peace Ark from China. 61
33547191 2021

Variations for Pleomorphic Lipoma

Expression for Pleomorphic Lipoma

Search GEO for disease gene expression data for Pleomorphic Lipoma.

Pathways for Pleomorphic Lipoma

Pathways related to Pleomorphic Lipoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.46 PGR CDK4
2 10.13 MDM2 CDK4

GO Terms for Pleomorphic Lipoma

Biological processes related to Pleomorphic Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell cycle GO:0045787 9.16 MDM2 CDK4
2 negative regulation of cell cycle arrest GO:0071157 8.96 MDM2 CDK4
3 paracrine signaling GO:0038001 8.62 PGR CD34

Sources for Pleomorphic Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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