MCID: PLM019
MIFTS: 43

Pleomorphic Liposarcoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Pleomorphic Liposarcoma

MalaCards integrated aliases for Pleomorphic Liposarcoma:

Name: Pleomorphic Liposarcoma 12 59 15
Liposarcoma, Pleomorphic 73
Liposarcoma Pleomorphic 55
Pls 59

Characteristics:

Orphanet epidemiological data:

59
pleomorphic liposarcoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:5702
MeSH 44 D008080
NCIt 50 C3705
SNOMED-CT 68 112683004 404071006
Orphanet 59 ORPHA99969
UMLS via Orphanet 74 C0205825
ICD10 via Orphanet 34 C49.9
SNOMED-CT via HPO 69 95325000
UMLS 73 C0205825

Summaries for Pleomorphic Liposarcoma

MalaCards based summary : Pleomorphic Liposarcoma, also known as liposarcoma, pleomorphic, is related to atypical lipomatous tumor and mesenchymoma. An important gene associated with Pleomorphic Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are DNA Damage and Cytoskeletal Signaling. The drugs Rosiglitazone and Pembrolizumab have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and breast, and related phenotypes are subcutaneous nodule and cardiovascular system

Related Diseases for Pleomorphic Liposarcoma

Diseases related to Pleomorphic Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 237)
# Related Disease Score Top Affiliating Genes
1 atypical lipomatous tumor 30.7 CDKN2A MDM2
2 mesenchymoma 30.3 DES MDM2
3 myxofibrosarcoma 30.2 DES S100B
4 malignant mesenchymoma 30.0 DES MDM2
5 liposarcoma 29.8 CDKN2A DES MDM2 VIM
6 epithelioid sarcoma 28.9 KRT8 MUC1 VIM
7 dedifferentiated liposarcoma 28.4 ACTC1 CDKN2A DES MDM2 MUC1
8 rhabdomyosarcoma 28.2 ACTC1 DES MDM2 VIM
9 fibrous histiocytoma 28.2 ACTC1 DES S100B VIM
10 malignant fibroxanthoma 26.9 ACTC1 DES MDM2 MUC1 S100B VIM
11 papillon-lefevre syndrome 12.0
12 platelet groups--pl system 11.9
13 lateral sclerosis 11.8
14 primary lateral sclerosis, adult, 1 11.8
15 primary lateral sclerosis, juvenile 11.7
16 pityriasis lichenoides 11.2
17 pancreatic lipase deficiency 11.0
18 haim-munk syndrome 11.0
19 potocki-lupski syndrome 10.9
20 motor neuron disease 10.8
21 enthesopathy 10.8
22 skin tag 10.8
23 proteus-like syndrome 10.8
24 infiltrating angiolipoma 10.7 CDKN2A MDM2
25 periosteal chondrosarcoma 10.7 CDKN2A MDM2
26 localized hypertrophic neuropathy 10.6 MUC1 S100B
27 sclerosing perineurioma 10.6 MUC1 S100B
28 intracranial cysts 10.6 MUC1 S100B
29 mucinous bronchioloalveolar adenocarcinoma 10.6 CDKN2A MUC1
30 reticular perineurioma 10.6 MUC1 S100B
31 cholangiolocellular carcinoma 10.6 CDKN2A MUC1
32 non-functioning pituitary adenoma 10.6 MUC1 S100B
33 sarcomatoid mesothelioma 10.6 CDKN2A MUC1
34 epithelioid malignant peripheral nerve sheath tumor 10.6 MUC1 S100B
35 aggressive digital papillary adenocarcinoma 10.6 MUC1 S100B
36 chordoid glioma 10.6 MUC1 S100B
37 fibrosarcoma of bone 10.6 CDKN2A MDM2
38 ovarian serous cystadenofibroma 10.5 INHA MUC1
39 functioning pituitary adenoma 10.5 MUC1 S100B
40 biliary tract neoplasm 10.5 CDKN2A MUC1
41 papilloma of choroid plexus 10.5 MUC1 S100B
42 peritoneal mesothelioma 10.5 CDKN2A MUC1
43 bizarre leiomyoma 10.5 ACTC1 CDKN2A
44 microcystic adenoma 10.5 INHA MUC1
45 malignant giant cell tumor of soft parts 10.5 ACTC1 S100B
46 malignant giant cell tumor 10.5 ACTC1 S100B
47 mucinous adenocarcinoma 10.5 CDKN2A MUC1
48 myopericytoma 10.5 ACTC1 S100B
49 glycogen-rich clear cell breast carcinoma 10.5 ACTC1 CDKN2A
50 cervical clear cell adenocarcinoma 10.4 CDKN2A KRT8

Graphical network of the top 20 diseases related to Pleomorphic Liposarcoma:



Diseases related to Pleomorphic Liposarcoma

Symptoms & Phenotypes for Pleomorphic Liposarcoma

Human phenotypes related to Pleomorphic Liposarcoma:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001482

MGI Mouse Phenotypes related to Pleomorphic Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 INHA KRT8 MDM2 VIM ACTC1 CDKN2A
2 homeostasis/metabolism MP:0005376 9.56 DES INHA KRT8 MDM2 S100B VIM
3 muscle MP:0005369 9.02 DES MDM2 VIM ACTC1 CDKN2A

Drugs & Therapeutics for Pleomorphic Liposarcoma

Drugs for Pleomorphic Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
2
Pembrolizumab Approved Phase 2 1374853-91-4
3
nivolumab Approved Phase 2 946414-94-4
4
Maleic acid Experimental Phase 2 110-16-7 444266
5 Hypoglycemic Agents Phase 2
6 Antibodies Phase 2
7 Immunoglobulins Phase 2
8 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Activity and Tolerability of Pazopanib in Advanced and/or Metastatic Liposarcoma. A Phase II Clinical Trial Unknown status NCT01692496 Phase 2 Pazopanib
2 Rosiglitazone in Treating Patients With Liposarcoma Completed NCT00004180 Phase 2 rosiglitazone maleate
3 A Study of Epacadostat, an IDO1 Inhibitor, in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced Sarcoma Recruiting NCT03414229 Phase 2 Epacadostat;Pembrolizumab
4 Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery Recruiting NCT02500797 Phase 2
5 Detection of Circulating Tumor Cells in Patients With Sarcomas Recruiting NCT02983539

Search NIH Clinical Center for Pleomorphic Liposarcoma

Genetic Tests for Pleomorphic Liposarcoma

Anatomical Context for Pleomorphic Liposarcoma

MalaCards organs/tissues related to Pleomorphic Liposarcoma:

41
Bone, Liver, Breast, Uterus, Prostate, Cervix, Ovary

Publications for Pleomorphic Liposarcoma

Articles related to Pleomorphic Liposarcoma:

(show top 50) (show all 93)
# Title Authors Year
1
Tumor-targeting Salmonella typhimurium A1-R arrests a doxorubicin-resistant PDGFRA-amplified patient-derived orthotopic xenograft mouse model of pleomorphic liposarcoma. ( 29932244 )
2018
2
Pleomorphic liposarcoma: An analysis of 6 case reports and literature review. ( 29465602 )
2018
3
Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour. ( 29449935 )
2018
4
Simultaneous pulmonary and inferior vena cava tumor thromboembolism secondary to retroperitoneal pleomorphic liposarcoma. ( 29550849 )
2018
5
Primary Pleomorphic Liposarcoma of Fallopian Tube with Recurrence: A Case Report and Review of the Literature. ( 29423449 )
2017
6
Effective apatinib treatment of pleomorphic liposarcoma: A case report. ( 28816958 )
2017
7
Association of Li-Fraumeni Syndrome With Small Cell Carcinoma of the Ovary, Hypercalcemic Type and Concurrent Pleomorphic Liposarcoma of the Cervix. ( 28177947 )
2017
8
A huge primary pleomorphic liposarcoma of the left atrium. ( 28747948 )
2017
9
Pleomorphic liposarcoma of the head and neck: Presentation of two cases and literature review. ( 28528729 )
2017
10
Primary dermal pleomorphic liposarcoma: utility of adipophilin and MDM2/CDK4 immunostainings. ( 27778364 )
2016
11
Cellular Angiofibroma With Sarcomatous Transformation Showing Pleomorphic Liposarcoma-Like and Atypical Lipomatous Tumor-Like Features. ( 26760687 )
2016
12
Cutaneous metastasis of pleomorphic liposarcoma to the scalp: an elusive diagnosis. ( 26968423 )
2016
13
Primary pleomorphic liposarcoma of the spine. Case report and review of the literature. ( 27351623 )
2016
14
Pleomorphic Liposarcoma Arising in a Lipoleiomyosarcoma of the Uterus: Report of a Case With Genetic Profiling by a Next Generation Sequencing Panel. ( 26598981 )
2015
15
Pleomorphic liposarcoma of the inferior vena cava. ( 25590403 )
2015
16
Primary pleomorphic liposarcoma of the thoracic epidural space: case report. ( 26343245 )
2015
17
Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence. ( 26881623 )
2015
18
Pleomorphic liposarcoma: A cytologic study of five cases. ( 24652822 )
2014
19
Small bowel pleomorphic liposarcoma: a rare cause of gastrointestinal bleeding. ( 25161780 )
2014
20
Pleomorphic liposarcoma of the hand. ( 24870378 )
2014
21
Rhabdomyosarcoma with pseudolipoblasts arising in ovarian carcinosarcoma: a distinctive postchemotherapy morphologic variant mimicking pleomorphic liposarcoma. ( 24587930 )
2014
22
The surgical management of a giant pleomorphic liposarcoma of the chest wall. ( 25392049 )
2014
23
Primary mediastinal pleomorphic liposarcoma involving the superior vena cava. ( 26767011 )
2014
24
Muir-Torre syndrome-associated pleomorphic liposarcoma arising in a previous radiation field. ( 23299928 )
2013
25
Liver Metastasis of Extremity Pleomorphic Liposarcoma Treated with Hepatic Resection. ( 23959373 )
2013
26
Dedifferentiated liposarcoma and pleomorphic liposarcoma: A comparative study of cytomorphology and MDM2/CDK4 expression on fine-needle aspiration. ( 24227706 )
2013
27
p14(ARF) methylation is a common event in the pathogenesis and progression of myxoid and pleomorphic liposarcoma. ( 23918242 )
2013
28
Primary pleomorphic liposarcoma of liver: a case report and review of the literature. ( 25374715 )
2013
29
Immediate reconstruction of the chest wall by latissimus dorsi and vertical rectus abdominis musculocutaneous flaps after radical mastectomy for a huge pleomorphic liposarcoma. ( 23350740 )
2013
30
Pleomorphic liposarcoma: a clinicopathological, immunohistochemical and molecular cytogenetic study of 32 additional cases. ( 24274714 )
2013
31
Dermal pleomorphic liposarcoma resembling pleomorphic fibroma: report of a case and review of the literature. ( 23651098 )
2013
32
Primary pleomorphic liposarcoma of the orbit: a case report. ( 22551368 )
2012
33
Earlier detection of bone metastases from pleomorphic liposarcoma in a pediatric patient by FDG PET/CT than planar 99mTc MDP bone scan. ( 22475918 )
2012
34
Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. ( 22472959 )
2012
35
Primary orbital pleomorphic liposarcoma: an aggressive course. ( 22460675 )
2012
36
Combined cutaneous sarcoma: pleomorphic liposarcoma and conventional osteosarcoma-the so-called malignant mesenchymoma. ( 23082265 )
2012
37
Prostatic adenocarcinoma metastatic to pleomorphic liposarcoma, a &amp;quot;collision phenomenon&amp;quot;: report of a case with review of pelvic collision tumors. ( 21904691 )
2011
38
Primary pleomorphic liposarcoma of bone in an adolescent: imaging features of a rare entity. ( 21573914 )
2011
39
Pleomorphic liposarcoma of the uterine corpus with focal smooth muscle differentiation. ( 21464725 )
2011
40
Metachronous pleomorphic liposarcoma and melanoma: a rare case report. ( 21393919 )
2011
41
Epithelioid variant of pleomorphic liposarcoma as potential mimic of metastatic carcinoma. ( 21464872 )
2011
42
Primary pleomorphic liposarcoma of breast: a rare case report. ( 21393893 )
2011
43
Pleomorphic liposarcoma: clinical observations and molecular variables. ( 21598240 )
2011
44
Orbital pleomorphic liposarcoma in an eight-year-old boy. ( 21417910 )
2011
45
Primary pleomorphic liposarcoma: a rare mediastinal tumor. ( 20719913 )
2010
46
Epithelioid variant of a pleomorphic liposarcoma displaying arborizing vascular arrangements on cytology smears: a case report of an interesting cytomorphologic pattern in an uncommon tumor. ( 21053578 )
2010
47
Metastasis after resection of huge primary pericardial pleomorphic liposarcoma with cardiopulmonary bypass. ( 20333575 )
2010
48
Pleomorphic liposarcoma originating from intracranial dura mater. ( 19727564 )
2010
49
Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. ( 20604797 )
2010
50
Doxorubicin resistance in a novel in vitro model of human pleomorphic liposarcoma associated with alternative lengthening of telomeres. ( 20197395 )
2010

Variations for Pleomorphic Liposarcoma

Copy number variations for Pleomorphic Liposarcoma from CNVD:

7 (show top 50) (show all 56)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 27943 1 216302655 221524000 Copy number DISP1 Pleomorphic liposarcoma
2 27944 1 216302655 221524000 Copy number MARK1 Pleomorphic liposarcoma
3 27945 1 216302655 221524000 Copy number MIA3 Pleomorphic liposarcoma
4 27946 1 216302655 221524000 Copy number TP53BP2 Pleomorphic liposarcoma
5 35867 1 68313202 77461343 Copy number MSH4 Pleomorphic liposarcoma
6 35868 1 68313202 77461343 Copy number TNNI3K Pleomorphic liposarcoma
7 38609 10 103687999 105303029 Copy number NFKB2 Pleomorphic liposarcoma
8 38610 10 103687999 105303029 Copy number SUFU Pleomorphic liposarcoma
9 39750 10 119097873 135323432 Copy number CTBP2 Pleomorphic liposarcoma
10 39751 10 119097873 135323432 Copy number FGFR2 Pleomorphic liposarcoma
11 45183 10 68571354 70982955 Copy number CCAR1 Pleomorphic liposarcoma
12 45184 10 68571354 70982955 Copy number CXXC6 Pleomorphic liposarcoma
13 45570 10 72407412 76912067 Copy number MYST4 Pleomorphic liposarcoma
14 67858 12 456768 1673782 Copy number ADIPOR2 Pleomorphic liposarcoma
15 67859 12 456768 1673782 Copy number ERC1 Pleomorphic liposarcoma
16 67860 12 456768 1673782 Copy number RAD52 Pleomorphic liposarcoma
17 67861 12 456768 1673782 Copy number WNT5B Pleomorphic liposarcoma
18 77885 13 47917390 48154504 Copy number RB1 Pleomorphic liposarcoma
19 104128 16 67103973 69257715 Copy number CDH1 Pleomorphic liposarcoma
20 104129 16 67103973 69257715 Copy number CDH3 Pleomorphic liposarcoma
21 104130 16 67103973 69257715 Copy number CTF8 Pleomorphic liposarcoma
22 104131 16 67103973 69257715 Copy number FUK Pleomorphic liposarcoma
23 104132 16 67103973 69257715 Copy number NQO1 Pleomorphic liposarcoma
24 109091 17 24079567 27921023 Copy number NF1 Pleomorphic liposarcoma
25 109092 17 24079567 27921023 Copy number SUZ12 Pleomorphic liposarcoma
26 116531 17 6791092 7741807 Copy number TP53 Pleomorphic liposarcoma
27 127073 19 24161928 40254153 Copy number CCNE1 Pleomorphic liposarcoma
28 127074 19 24161928 40254153 Copy number CEBPA Pleomorphic liposarcoma
29 127075 19 24161928 40254153 Copy number LRP3 Pleomorphic liposarcoma
30 127413 19 32690406 34776985 Copy number UQCRFS1 Pleomorphic liposarcoma
31 127995 19 38552698 38678914 Copy number CEBPG Pleomorphic liposarcoma
32 128402 19 40680588 41040430 Copy number ETV2 Pleomorphic liposarcoma
33 128403 19 40680588 41040430 Copy number MLL4 Pleomorphic liposarcoma
34 128404 19 40680588 41040430 Copy number PSENEN Pleomorphic liposarcoma
35 164748 22 39296203 46069760 Copy number EP300 Pleomorphic liposarcoma
36 164749 22 39296203 46069760 Copy number MKL1 Pleomorphic liposarcoma
37 164750 22 39296203 46069760 Copy number PPARA Pleomorphic liposarcoma
38 164751 22 39296203 46069760 Copy number ST13 Pleomorphic liposarcoma
39 164752 22 39296203 46069760 Copy number XRCC6 Pleomorphic liposarcoma
40 192151 5 10731281 11126282 Copy number DAP Pleomorphic liposarcoma
41 192512 5 11413893 15762298 Copy number CTNND2 Pleomorphic liposarcoma
42 192513 5 11413893 15762298 Copy number FBXL7 Pleomorphic liposarcoma
43 196379 5 165712 5444231 Copy number TERT Pleomorphic liposarcoma
44 198926 5 32750418 45758751 Copy number AMACR Pleomorphic liposarcoma
45 198927 5 32750418 45758751 Copy number C1QTNF3 Pleomorphic liposarcoma
46 198928 5 32750418 45758751 Copy number LIFR Pleomorphic liposarcoma
47 198929 5 32750418 45758751 Copy number RAD1 Pleomorphic liposarcoma
48 198930 5 32750418 45758751 Copy number SKP2 Pleomorphic liposarcoma
49 223658 7 23715756 32063427 Copy number HOXA11 Pleomorphic liposarcoma
50 223659 7 23715756 32063427 Copy number HOXA13 Pleomorphic liposarcoma

Expression for Pleomorphic Liposarcoma

Search GEO for disease gene expression data for Pleomorphic Liposarcoma.

Pathways for Pleomorphic Liposarcoma

Pathways related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.08 CDKN2A MDM2 VIM
2 11.51 ACTC1 DES KRT8 MUC1 VIM
3
Show member pathways
11.37 DES KRT8 VIM
4
Show member pathways
11.06 DES VIM
5 10.99 ACTC1 DES VIM
6 10.87 CDKN2A MDM2
7 10.66 CDKN2A MDM2
8
Show member pathways
10.6 CDKN2A MDM2

GO Terms for Pleomorphic Liposarcoma

Cellular components related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.28 ACTC1 CDKN2A DES INHA KRT8 MDM2
2 intermediate filament GO:0005882 9.13 DES KRT8 VIM

Biological processes related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.46 ACTC1 CDKN2A MDM2 VIM
2 protein destabilization GO:0031648 9.37 CDKN2A MDM2
3 negative regulation of phosphorylation GO:0042326 9.32 CDKN2A INHA
4 intermediate filament organization GO:0045109 9.26 DES VIM
5 amyloid fibril formation GO:1990000 8.96 CDKN2A MDM2
6 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 9.16 CDKN2A MDM2
2 SUMO transferase activity GO:0019789 8.96 CDKN2A MDM2
3 scaffold protein binding GO:0097110 8.8 KRT8 MDM2 VIM

Sources for Pleomorphic Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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