PLS
MCID: PLM019
MIFTS: 39

Pleomorphic Liposarcoma (PLS)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Pleomorphic Liposarcoma

MalaCards integrated aliases for Pleomorphic Liposarcoma:

Name: Pleomorphic Liposarcoma 12 58 15 17
Liposarcoma, Pleomorphic 70
Liposarcoma Pleomorphic 54
Pls 58

Characteristics:

Orphanet epidemiological data:

58
pleomorphic liposarcoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:5702
MeSH 44 D008080
NCIt 50 C3705
SNOMED-CT 67 404071006
ICD10 via Orphanet 33 C49.9
UMLS via Orphanet 71 C0205825
Orphanet 58 ORPHA99969
SNOMED-CT via HPO 68 254829001 49430005 95325000
UMLS 70 C0205825

Summaries for Pleomorphic Liposarcoma

MalaCards based summary : Pleomorphic Liposarcoma, also known as liposarcoma, pleomorphic, is related to liposarcoma of bone and rare tumor. An important gene associated with Pleomorphic Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Pathways in cancer and Cytoskeletal Signaling. Affiliated tissues include breast, bone and skin, and related phenotypes are liposarcoma and subcutaneous nodule

Related Diseases for Pleomorphic Liposarcoma

Diseases related to Pleomorphic Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 444)
# Related Disease Score Top Affiliating Genes
1 liposarcoma of bone 30.7 MDM2 CDK4
2 rare tumor 30.5 KIT EWSR1 DES ACTC1
3 liposarcoma 30.3 VIM PDGFRA MDM2 FUS EWSR1 DES
4 epithelioid sarcoma 30.2 VIM MUC1 KRT8
5 pleomorphic lipoma 30.2 SERPINA3 MDM2 CDK4
6 leiomyoma 30.1 VIM PDGFRA KIT DES ACTC1
7 breast malignant phyllodes tumor 30.1 SERPINA3 KIT
8 ovarian small cell carcinoma 30.1 S100B MUC1 INHA DES
9 benign breast phyllodes tumor 30.1 VIM KIT
10 fibroma 30.1 VIM SERPINA3 DES ACTC1
11 skin sarcoma 30.1 KIT CALD1
12 small cell carcinoma 29.9 PDGFRA MUC1 KRT8 KIT CDKN2A
13 bone sarcoma 29.8 SERPINA3 MDM2 EWSR1 CDK4
14 constipation 29.8 VIM S100B KIT EWSR1
15 mantle cell lymphoma 29.8 MDM2 KIT CDKN2A CDK4
16 carcinosarcoma 29.7 VIM MUC1 KIT DES CDKN2A ACTC1
17 fibrous histiocytoma 29.6 VIM SERPINA3 S100B KIT FUS EWSR1
18 gastrointestinal stromal tumor 29.5 VIM S100B PDGFRA KIT DES CDKN2A
19 malignant fibrous histiocytoma 29.3 VIM SERPINA3 S100B MUC1 MDM2 EWSR1
20 malignant mesenchymoma 29.2 SSX2 SERPINA3 MDM2 DES CALD1
21 chondrosarcoma 29.0 VIM SERPINA3 S100B PDGFRA MUC1 MDM2
22 leiomyosarcoma 28.9 VIM SERPINA3 S100B PDGFRA MUC1 MDM2
23 myxoid liposarcoma 28.8 SSX2 SS18 MDM2 FUS EWSR1 DDIT3
24 lipomatosis, multiple 28.4 SERPINA3 MDM2 KIT FUS EWSR1 DES
25 rhabdomyosarcoma 28.1 VIM SSX2 S100B PDGFRA MDM2 KIT
26 spindle cell sarcoma 27.7 VIM SSX2 SS18 SERPINA3 S100B MUC1
27 cellular myxoid liposarcoma 27.6 YEATS4 SSX2 SS18 SERPINA3 MDM2 FUS
28 sarcoma 27.4 VIM SSX2 SS18 S100B PDGFRA MUC1
29 myxofibrosarcoma 27.2 SSX2 SS18 SERPINA3 S100B MUC1 MDM2
30 well-differentiated liposarcoma 26.9 YEATS4 SSX2 SS18 SERPINA3 PDGFRA MUC1
31 dedifferentiated liposarcoma 26.6 YEATS4 SSX2 SS18 SERPINA3 S100B MUC1
32 papillon-lefevre syndrome 11.6
33 lateral sclerosis 11.6
34 primary lateral sclerosis, juvenile 11.5
35 primary lateral sclerosis, adult, 1 11.5
36 haim-munk syndrome 11.0
37 motor neuron disease 11.0
38 potocki-lupski syndrome 10.9
39 proteus-like syndrome 10.9
40 soft tissue sarcoma 10.5
41 esophagus verrucous carcinoma 10.4 MDM2 CDKN2A
42 fibroblastic rheumatism 10.4 DES ACTC1
43 inflammatory liposarcoma 10.4 MDM2 CDKN2A
44 malignant peritoneal mesothelioma 10.4 MUC1 CDKN2A
45 lymphangiectasis 10.4 VIM ACTC1
46 vulvar eccrine porocarcinoma 10.4 MUC1 CDKN2A
47 infantile digital fibromatosis 10.4 VIM DES
48 myopericytoma 10.4 S100B ACTC1
49 sclerosing perineurioma 10.4 S100B MUC1
50 localized hypertrophic neuropathy 10.4 S100B MUC1

Graphical network of the top 20 diseases related to Pleomorphic Liposarcoma:



Diseases related to Pleomorphic Liposarcoma

Symptoms & Phenotypes for Pleomorphic Liposarcoma

Human phenotypes related to Pleomorphic Liposarcoma:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 liposarcoma 58 31 obligate (100%) Obligate (100%) HP:0012034
2 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482

GenomeRNAi Phenotypes related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.75 FUS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.75 CDK4
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.75 CDK4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 9.75 EWSR1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.75 EWSR1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.75 PDGFRA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-140 9.75 EWSR1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.75 EWSR1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-21 9.75 CDK4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.75 EWSR1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-3 9.75 FUS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.75 CDK4
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-46 9.75 CDK4
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.75 EWSR1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.75 CDK4 EWSR1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-57 9.75 FUS
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.75 FUS
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 9.75 FUS PDGFRA
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-76 9.75 SSX2
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.75 CDK4 EWSR1 FUS
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.75 EWSR1 SSX2
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.75 EWSR1

MGI Mouse Phenotypes related to Pleomorphic Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.1 ACTC1 CDK4 CDKN2A DDIT3 DES INHA
2 homeostasis/metabolism MP:0005376 10 ACTC1 CDK4 CDKN2A DDIT3 DES INHA
3 embryo MP:0005380 9.91 ACTC1 CDK4 CDKN2A KIT KRT8 MDM2
4 muscle MP:0005369 9.56 ACTC1 CDK4 CDKN2A DES KIT MDM2
5 neoplasm MP:0002006 9.17 CDK4 CDKN2A DDIT3 INHA KIT MDM2

Drugs & Therapeutics for Pleomorphic Liposarcoma

Search Clinical Trials , NIH Clinical Center for Pleomorphic Liposarcoma

Genetic Tests for Pleomorphic Liposarcoma

Anatomical Context for Pleomorphic Liposarcoma

MalaCards organs/tissues related to Pleomorphic Liposarcoma:

40
Breast, Bone, Skin, Kidney, Pancreas, Ovary, Colon

Publications for Pleomorphic Liposarcoma

Articles related to Pleomorphic Liposarcoma:

(show top 50) (show all 321)
# Title Authors PMID Year
1
Cellular angiofibroma with atypia or sarcomatous transformation: clinicopathologic analysis of 13 cases. 61 54
20305534 2010
2
Molecular classification of soft tissue sarcomas and its clinical applications. 61 54
20490332 2010
3
The Rapidly Expanding Group of RB1-Deleted Soft Tissue Tumors: An Updated Review. 61
33802620 2021
4
Liposarcoma in children and young adults: a clinicopathologic and molecular study of 23 cases in one of the largest institutions of China. 61
33738541 2021
5
Survivorship and prognostic factors for pleomorphic liposarcoma: a population-based study. 61
33663547 2021
6
Establishment and characterization of NCC-PLPS1-C1, a novel patient-derived cell line of pleomorphic liposarcoma. 61
33205363 2021
7
Correction to: Survivorship and prognostic factors for pleomorphic liposarcoma: a population-based study. 61
33781301 2021
8
Atypical Pleomorphic Lipomatous Tumor: Expanding Our Current Understanding in a Clinicopathologic Analysis of 64 Cases. 61
33782225 2021
9
DDIT3 Immunohistochemistry Is a Useful Tool for the Diagnosis of Myxoid Liposarcoma. 61
32815829 2021
10
Broadening the spectrum of NTRK rearranged mesenchymal tumors and usefulness of pan-TRK immunohistochemistry for identification of NTRK fusions. 61
32860002 2021
11
Recent advances in the understanding and management of liposarcoma. 61
33659920 2021
12
The rare primary bone sarcomas: imaging-pathological correlation. 61
33410967 2021
13
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on 18F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma. 61
33505228 2021
14
Primary Lesser Sac Pleomorphic Liposarcoma Mimicking Gastric GIST. 61
33158595 2020
15
Recurrent Primary Pleomorphic Liposarcoma of the Breast: A Case Report with Imaging Findings. 61
33154832 2020
16
Cytopathology of myxofibrosarcoma: a study of 66 cases and literature review. 61
33041221 2020
17
Mediastinal liposarcoma masquerading as penetrating aortic ulcer in the descending aorta: a case report. 61
32968644 2020
18
A Reappraisal of Superficial Pleomorphic Liposarcoma. 61
32525520 2020
19
Primary anatomical site as a prognostic factor for pleomorphic liposarcoma. 61
32248301 2020
20
[Systemic Therapy Options for Locally Advanced and Metastatic Myxoid, Dedifferentiated and Pleomorphic Liposarcoma]. 61
32268388 2020
21
Recurrent Pleomorphic Myxoid Liposarcoma in a Patient With Li-Fraumeni Syndrome. 61
31559875 2020
22
From head and neck lipoma to liposarcoma: a wide spectrum of differential diagnoses and their therapeutic implications. 61
32011399 2020
23
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma with Myxoid Stroma in a Hereditary Retinoblastoma Survivor. 61
32258014 2020
24
Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas. 61
32313727 2020
25
What's new in adipocytic neoplasia? 61
31501988 2020
26
Lipomatous Tumors in Pediatric Patients: A Retrospective Analysis of 50 cases. 61
31282548 2020
27
Toxic epidermal necrolysis after radiotherapy for pleomorphic liposarcoma. 61
32155033 2020
28
Pleomorphic Liposarcoma of Finger-a Rare Entity. 61
31857768 2019
29
Cerebral pleomorphic liposarcoma: Clinicopathologic findings. 61
31347491 2019
30
Sonographic Appearances of Liposarcoma: Correlations with Pathologic Subtypes. 61
31202456 2019
31
Abnormal vascularization of soft-tissue sarcomas on conventional MRI: Diagnostic and prognostic values. 61
31307635 2019
32
CBX3 predicts an unfavorable prognosis and promotes tumorigenesis in osteosarcoma. 61
30942427 2019
33
Pleomorphic liposarcoma of chest wall: a rare entity with challenging management. 61
30808192 2019
34
Dedifferentiated Liposarcoma of the Left Thigh: a Rare Case. 61
31391701 2019
35
PRDM10-rearranged Soft Tissue Tumor: A Clinicopathologic Study of 9 Cases. 61
30570551 2019
36
Pleomorphic liposarcoma: Updates and current differential diagnosis. 61
30852046 2019
37
Real-World Experiences with Pazopanib in Patients with Advanced Soft Tissue and Bone Sarcoma in Northern California. 61
30889920 2019
38
A contemporary review of myxoid adipocytic tumors. 61
30853315 2019
39
Free latissimus dorsi musculocutaneous flap for external hemipelvectomy reconstruction. 61
30191595 2019
40
Immunophenotypic expression of UCP1 in hibernoma and other adipose/non adipose soft tissue tumours. 61
31114671 2019
41
Retrospective Analysis of Patients with Advanced Liposarcoma in a Tertiary Referral Center. 61
31170709 2019
42
Subclassification of pleomorphic sarcomas: How and why should we care? 61
30340082 2018
43
Atypical spindle cell/pleomorphic lipomatous tumor: A clinicopathologic, immunohistochemical, and molecular study of 20 cases. 61
30198097 2018
44
Tumor-targeting Salmonella typhimurium A1-R arrests a doxorubicin-resistant PDGFRA-amplified patient-derived orthotopic xenograft mouse model of pleomorphic liposarcoma. 61
29932244 2018
45
Doxorubicin-resistant pleomorphic liposarcoma with PDGFRA gene amplification is targeted and regressed by pazopanib in a patient-derived orthotopic xenograft mouse model. 61
30060824 2018
46
Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model. 61
30126369 2018
47
Growing Role of Regorafenib in the Treatment of Patients with Sarcoma. 61
29931504 2018
48
Amplification of FRS2 in atypical lipomatous tumour/well-differentiated liposarcoma and de-differentiated liposarcoma: a clinicopathological and genetic study of 146 cases. 61
29368794 2018
49
[Clinical experience in diagnosis and treatment of primary retroperitoneal liposarcoma]. 61
29562404 2018
50
Pleomorphic liposarcoma: An analysis of 6 case reports and literature review. 61
29465602 2018

Variations for Pleomorphic Liposarcoma

Copy number variations for Pleomorphic Liposarcoma from CNVD:

7 (show top 50) (show all 56)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 27943 1 216302655 221524000 Copy number DISP1 Pleomorphic liposarcoma
2 27944 1 216302655 221524000 Copy number MARK1 Pleomorphic liposarcoma
3 27945 1 216302655 221524000 Copy number MIA3 Pleomorphic liposarcoma
4 27946 1 216302655 221524000 Copy number TP53BP2 Pleomorphic liposarcoma
5 35867 1 68313202 77461343 Copy number MSH4 Pleomorphic liposarcoma
6 35868 1 68313202 77461343 Copy number TNNI3K Pleomorphic liposarcoma
7 38609 10 103687999 105303029 Copy number NFKB2 Pleomorphic liposarcoma
8 38610 10 103687999 105303029 Copy number SUFU Pleomorphic liposarcoma
9 39750 10 119097873 135323432 Copy number CTBP2 Pleomorphic liposarcoma
10 39751 10 119097873 135323432 Copy number FGFR2 Pleomorphic liposarcoma
11 45183 10 68571354 70982955 Copy number CCAR1 Pleomorphic liposarcoma
12 45184 10 68571354 70982955 Copy number TET1 Pleomorphic liposarcoma
13 45570 10 72407412 76912067 Copy number KAT6B Pleomorphic liposarcoma
14 67858 12 456768 1673782 Copy number ADIPOR2 Pleomorphic liposarcoma
15 67859 12 456768 1673782 Copy number ERC1 Pleomorphic liposarcoma
16 67860 12 456768 1673782 Copy number RAD52 Pleomorphic liposarcoma
17 67861 12 456768 1673782 Copy number WNT5B Pleomorphic liposarcoma
18 77885 13 47917390 48154504 Copy number RB1 Pleomorphic liposarcoma
19 104128 16 67103973 69257715 Copy number CDH1 Pleomorphic liposarcoma
20 104129 16 67103973 69257715 Copy number CDH3 Pleomorphic liposarcoma
21 104130 16 67103973 69257715 Copy number CHTF8 Pleomorphic liposarcoma
22 104131 16 67103973 69257715 Copy number FCSK Pleomorphic liposarcoma
23 104132 16 67103973 69257715 Copy number NQO1 Pleomorphic liposarcoma
24 109091 17 24079567 27921023 Copy number NF1 Pleomorphic liposarcoma
25 109092 17 24079567 27921023 Copy number SUZ12 Pleomorphic liposarcoma
26 116531 17 6791092 7741807 Copy number TP53 Pleomorphic liposarcoma
27 127073 19 24161928 40254153 Copy number CCNE1 Pleomorphic liposarcoma
28 127074 19 24161928 40254153 Copy number CEBPA Pleomorphic liposarcoma
29 127075 19 24161928 40254153 Copy number LRP3 Pleomorphic liposarcoma
30 127413 19 32690406 34776985 Copy number UQCRFS1 Pleomorphic liposarcoma
31 127995 19 38552698 38678914 Copy number CEBPG Pleomorphic liposarcoma
32 128402 19 40680588 41040430 Copy number ETV2 Pleomorphic liposarcoma
33 128403 19 40680588 41040430 Copy number KMT2B Pleomorphic liposarcoma
34 128404 19 40680588 41040430 Copy number PSENEN Pleomorphic liposarcoma
35 164748 22 39296203 46069760 Copy number EP300 Pleomorphic liposarcoma
36 164749 22 39296203 46069760 Copy number MRTFA Pleomorphic liposarcoma
37 164750 22 39296203 46069760 Copy number PPARA Pleomorphic liposarcoma
38 164751 22 39296203 46069760 Copy number ST13 Pleomorphic liposarcoma
39 164752 22 39296203 46069760 Copy number XRCC6 Pleomorphic liposarcoma
40 192151 5 10731281 11126282 Copy number DAP Pleomorphic liposarcoma
41 192512 5 11413893 15762298 Copy number CTNND2 Pleomorphic liposarcoma
42 192513 5 11413893 15762298 Copy number FBXL7 Pleomorphic liposarcoma
43 196379 5 165712 5444231 Copy number TERT Pleomorphic liposarcoma
44 198926 5 32750418 45758751 Copy number AMACR Pleomorphic liposarcoma
45 198927 5 32750418 45758751 Copy number C1QTNF3 Pleomorphic liposarcoma
46 198928 5 32750418 45758751 Copy number LIFR Pleomorphic liposarcoma
47 198929 5 32750418 45758751 Copy number RAD1 Pleomorphic liposarcoma
48 198930 5 32750418 45758751 Copy number SKP2 Pleomorphic liposarcoma
49 223658 7 23715756 32063427 Copy number HOXA11 Pleomorphic liposarcoma
50 223659 7 23715756 32063427 Copy number HOXA13 Pleomorphic liposarcoma

Expression for Pleomorphic Liposarcoma

Search GEO for disease gene expression data for Pleomorphic Liposarcoma.

Pathways for Pleomorphic Liposarcoma

GO Terms for Pleomorphic Liposarcoma

Cellular components related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.86 VIM S100B PDGFRA MUC1 MDM2 KRT8
2 nucleus GO:0005634 9.53 YEATS4 VIM SSX2 SS18 SERPINA3 S100B
3 intermediate filament cytoskeleton GO:0045111 9.33 VIM KRT8 DES

Biological processes related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.83 S100B PDGFRA MDM2 KIT CDK4
2 positive regulation of gene expression GO:0010628 9.72 VIM MDM2 KIT CDKN2A ACTC1
3 positive regulation of phospholipase C activity GO:0010863 9.4 PDGFRA KIT
4 amyloid fibril formation GO:1990000 9.37 MDM2 CDKN2A
5 cardiac myofibril assembly GO:0055003 9.26 PDGFRA ACTC1
6 somatic stem cell division GO:0048103 9.16 KIT CDKN2A
7 muscle filament sliding GO:0030049 9.13 VIM DES ACTC1
8 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043618 8.62 MUC1 DDIT3

Molecular functions related to Pleomorphic Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 YEATS4 VIM SSX2 SS18 SERPINA3 S100B
2 p53 binding GO:0002039 8.8 MUC1 MDM2 CDKN2A

Sources for Pleomorphic Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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