MCID: PLT001
MIFTS: 34

Plethora of Newborn

Categories: Blood diseases

Aliases & Classifications for Plethora of Newborn

MalaCards integrated aliases for Plethora of Newborn:

Name: Plethora of Newborn 12 15
Neonatal Polycythemia 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11242
ICD10 33 P61.1
ICD9CM 35 776.4
NCIt 50 C27069
SNOMED-CT 68 32984002 9170001
UMLS 73 C0272153

Summaries for Plethora of Newborn

MalaCards based summary : Plethora of Newborn, also known as neonatal polycythemia, is related to polycythemia and hereditary leiomyomatosis and renal cell cancer. An important gene associated with Plethora of Newborn is PSMA7 (Proteasome Subunit Alpha 7), and among its related pathways/superpathways are Pathways in cancer and Pyruvate metabolism and Citric Acid (TCA) cycle. The drugs Oxytocin and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include kidney, lymph node and thyroid, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and Increased shRNA abundance

Related Diseases for Plethora of Newborn

Diseases related to Plethora of Newborn via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 polycythemia 31.1 EGLN1 EPAS1 EPO
2 hereditary leiomyomatosis and renal cell cancer 10.2 FH SDHB
3 glomus tumor 10.2 SDHB SDHD
4 autosomal dominant secondary polycythemia 10.1 EGLN1 EPAS1 EPO
5 hypoxia 10.1 EGLN1 EPAS1 PSMA7
6 erythrocytosis, familial, 2 10.1 EGLN1 EPAS1 EPO
7 paraganglioma 10.1 SDHB SDHC SDHD
8 neural crest tumor 10.1 SDHB SDHC SDHD
9 extra-adrenal pheochromocytoma 10.1 SDHB SDHC SDHD
10 acquired polycythemia 10.1 EPO TF
11 paragangliomas 1 10.1 SDHB SDHC SDHD
12 folic acid deficiency anemia 10.1 EPO TF
13 chondroma 10.1 SDHB SDHC SDHD
14 paraganglioma and gastric stromal sarcoma 10.1 SDHB SDHC SDHD
15 carney triad 10.1 SDHB SDHC SDHD
16 malignant pheochromocytoma 10.1 CALCA SDHB
17 neurofibromatosis, type iv, of riccardi 10.1 SDHB SDHC SDHD
18 von hippel-lindau syndrome 10.1 SDHB SDHC SDHD
19 cloacogenic carcinoma 10.1 CALCA PTPRC
20 secondary hyperparathyroidism of renal origin 10.1 CALCA EPO
21 gastrointestinal stromal tumor 10.1 SDHB SDHC SDHD
22 pure red-cell aplasia 10.1 EPO TF
23 cerebellopontine angle tumor 10.0 ENSG00000255292 SDHD
24 sheehan syndrome 10.0 EPO INS
25 diabetic autonomic neuropathy 10.0 EPO INS
26 fetal erythroblastosis 10.0 EPO INS
27 multiple endocrine neoplasia 10.0 CALCA SDHB SDHC
28 duodenal somatostatinoma 10.0 CALCA INS
29 multiple endocrine neoplasia, type iia 10.0 CALCA SDHB SDHD
30 analbuminemia 10.0 EPO TF
31 vitamin b12 deficiency 10.0 EPO TF
32 persistent generalized lymphadenopathy 10.0 EPAS1 SDHB SDHC SDHD
33 sporadic pheochromocytoma 10.0 EPAS1 SDHB SDHC SDHD
34 autonomic nervous system disease 10.0 CALCA INS
35 hereditary paraganglioma-pheochromocytoma syndromes 10.0 FH SDHB SDHC SDHD
36 iron metabolism disease 10.0 EPO TF
37 hemosiderosis 10.0 EPO TF
38 multiple endocrine neoplasia, type i 10.0 INS SDHB SDHD
39 primary polycythemia 9.9 EGLN1 EPO
40 somatostatinoma 9.9 CALCA EPAS1 INS
41 cowden disease 9.9 CALCA SDHB SDHC SDHD
42 thrombocytopenia 9.9
43 adrenal medulla cancer 9.9 ENSG00000255292 SDHB SDHC SDHD
44 mitochondrial complex ii deficiency 9.9 ENSG00000255292 SDHB SDHC SDHD
45 uremia 9.9 EPO INS TF
46 urinary system disease 9.9 EPO INS TF
47 islet cell tumor 9.9 CALCA INS
48 autosomal genetic disease 9.8 ENSG00000255292 INS SDHB SDHD
49 hypoglycemia 9.8
50 eisenmenger syndrome 9.8

Graphical network of the top 20 diseases related to Plethora of Newborn:



Diseases related to Plethora of Newborn

Symptoms & Phenotypes for Plethora of Newborn

GenomeRNAi Phenotypes related to Plethora of Newborn according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.13 FH INS PTPRC
2 Increased shRNA abundance GR00327-A 8.92 CALCA EPO FH INS

MGI Mouse Phenotypes related to Plethora of Newborn:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 EGLN1 EPAS1 EPO INS PTPRC SDHB
2 homeostasis/metabolism MP:0005376 9.65 EGLN1 EPAS1 EPO FH INS PTPRC
3 mortality/aging MP:0010768 9.32 EGLN1 EPAS1 EPO FH INS PTPRC

Drugs & Therapeutics for Plethora of Newborn

Drugs for Plethora of Newborn (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Not Applicable 50-56-6 439302 53477758
2
Dinoprostone Approved Not Applicable 363-24-6 5280360
3
Iron Approved Not Applicable 7439-89-6 23925
4 Ferric Compounds Not Applicable
5 Ferric oxide, saccharated Not Applicable
6 Micronutrients Not Applicable
7 Hematinics Not Applicable
8 Trace Elements Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gestational Diabetes: Induction Versus Expectant Management of Labour Completed NCT01058772 Not Applicable
2 Pregnancy Outcomes and Medical Costs According to Gestational Diabetes Mellitus Diagnostic Criteria Recruiting NCT03421262 Not Applicable
3 To Compare the Efficacy of I.V 200 mg Iron Sucrose and 500 mg Iron Sucrose to Treat Anemia in Pregnancy Not yet recruiting NCT02441439 Not Applicable

Search NIH Clinical Center for Plethora of Newborn

Genetic Tests for Plethora of Newborn

Anatomical Context for Plethora of Newborn

MalaCards organs/tissues related to Plethora of Newborn:

41
Kidney, Lymph Node, Thyroid

Publications for Plethora of Newborn

Articles related to Plethora of Newborn:

(show top 50) (show all 53)
# Title Authors Year
1
Macular hemorrhages associated with neonatal polycythemia and thrombocytopenia: A case report. ( 28041861 )
2016
2
Restrictive management of neonatal polycythemia. ( 21667428 )
2011
3
Neonatal polycythemia and hyperviscosity. ( 18424246 )
2008
4
Increased energy expenditure after dilutional exchange transfusion for neonatal polycythemia. ( 17914128 )
2007
5
Crystalloid or colloid for partial exchange transfusion in neonatal polycythemia: a systematic review and meta-analysis. ( 16303705 )
2005
6
Neonatal polycythemia: is partial exchange transfusion justified? ( 15325537 )
2004
7
Neonatal polycythemia. ( 11802122 )
2002
8
Maternal smoking and partial exchange transfusion for neonatal polycythemia. ( 12442223 )
2002
9
Neonatal polycythemia: effects of partial exchange transfusion using fresh frozen plasma, Haemaccel and normal saline. ( 10730524 )
1999
10
Neonatal polycythemia. ( 10771885 )
1997
11
Neonatal polycythemia and hyperviscosity. ( 8521689 )
1995
12
Symptomatic neonatal polycythemia: comparison of partial exchange transfusion with saline versus plasma. ( 8772864 )
1995
13
Developmental outcome of infants with neonatal polycythemia. ( 7798839 )
1994
14
Neonatal polycythemia and maternal hypertension. ( 8193483 )
1994
15
Neonatal polycythemia in appropriately grown infants of hypertensive mothers. ( 1421903 )
1992
16
Effects of neonatal polycythemia and hemodilution on capillary perfusion. ( 1625066 )
1992
17
Neonatal polycythemia--issues and current perspectives. ( 2094665 )
1990
18
Diagnostic value of arterial hematocrits in neonatal polycythemia. ( 2275370 )
1990
19
Diagnostic errors in neonatal polycythemia based on method of hematocrit determination. ( 2769507 )
1989
20
Pathogenesis of hypocalcemia in neonatal polycythemia. ( 2796808 )
1989
21
The association between neonatal polycythemia, hypocalcemia, and hypoglycemia. ( 2812827 )
1989
22
Hemodynamic consequences of neonatal polycythemia. ( 3819947 )
1987
23
Neonatal polycythemia. ( 3511518 )
1986
24
Neonatal polycythemia and hyperviscosity. ( 3714337 )
1986
25
Neonatal polycythemia: frequency of clinical manifestations and other associated findings. ( 3725498 )
1986
26
Neonatal polycythemia in infants of insulin-dependent diabetic mothers. ( 3737061 )
1986
27
Left ventricular function in normal newborn infants and asymptomatic infants with neonatal polycythemia. ( 3751864 )
1986
28
Partial plasma exchange transfusion improves cerebral hemodynamics in symptomatic neonatal polycythemia. ( 3953635 )
1986
29
Effects of neonatal polycythemia and partial exchange transfusion on cardiac function: an echocardiographic study. ( 4069859 )
1985
30
Neonatal polycythemia in Hawaii. ( 6511389 )
1984
31
Neonatal polycythemia: II. Definition related to time of sampling. ( 6691031 )
1984
32
Neonatal polycythemia: I. Early diagnosis and incidence relating to time of sampling. ( 6691043 )
1984
33
Neonatal polycythemia. ( 6702518 )
1984
34
Neonatal polycythemia--a potentially serious disorder. ( 6618574 )
1983
35
Incidence of neonatal polycythemia. ( 6643026 )
1983
36
Serum erythropoietin levels in neonatal polycythemia. ( 6674257 )
1983
37
Peripheral venous partial exchange transfusions for neonatal polycythemia. ( 6848290 )
1983
38
Body water estimates in neonatal polycythemia. ( 6848708 )
1983
39
Eisenmenger syndrome in pregnancy: a possible cause of neonatal polycythemia and persistent fetal circulation. ( 7145258 )
1982
40
Normal coagulation findings, thrombocytopenia, and peripheral hemoconcentration in neonatal polycythemia. ( 7086629 )
1982
41
Neonatal polycythemia. ( 7088623 )
1982
42
Neonatal polycythemia and hyperviscosity. ( 7133792 )
1982
43
Neonatal polycythemia: II. Plasma, blood and red cell volume estimates in relation to hematocrit levels and quality of intrauterine growth. ( 7196569 )
1981
44
Neonatal polycythemia and the hyperviscosity syndrome. ( 7233966 )
1981
45
Neonatal polycythemia: I. Criteria for diagnosis and treatment. ( 7267222 )
1981
46
Neonatal polycythemia causing multiple cerebral infarcts. ( 7356402 )
1980
47
Neonatal polycythemia and chest roentgenograms. ( 143365 )
1977
48
Neonatal polycythemia in low birthweight infant. ( 1000018 )
1976
49
Neonatal polycythemia hyperviscosity syndrome. ( 237826 )
1975
50
Neonatal polycythemia (case report). ( 4417955 )
1974

Variations for Plethora of Newborn

Expression for Plethora of Newborn

Search GEO for disease gene expression data for Plethora of Newborn.

Pathways for Plethora of Newborn

GO Terms for Plethora of Newborn

Cellular components related to Plethora of Newborn according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.56 ENSG00000255292 SDHB SDHC SDHD
2 mitochondrial envelope GO:0005740 9.16 ENSG00000255292 SDHD
3 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 ENSG00000255292 SDHB SDHC SDHD

Biological processes related to Plethora of Newborn according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.72 EGLN1 ENSG00000255292 SDHB SDHC SDHD
2 response to hypoxia GO:0001666 9.61 EGLN1 EPAS1 EPO
3 acute-phase response GO:0006953 9.49 EPO INS
4 iron ion homeostasis GO:0055072 9.48 EPAS1 TF
5 aerobic respiration GO:0009060 9.46 SDHB SDHC
6 leukocyte cell-cell adhesion GO:0007159 9.4 CALCA PTPRC
7 positive regulation of blood vessel diameter GO:0097755 9.37 CALCA INS
8 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.33 EGLN1 EPAS1 EPO
9 negative regulation of calcium ion transport into cytosol GO:0010523 9.26 CALCA EPO
10 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.13 ENSG00000255292 SDHC SDHD
11 tricarboxylic acid cycle GO:0006099 9.02 ENSG00000255292 FH SDHB SDHC SDHD

Molecular functions related to Plethora of Newborn according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.5 ENSG00000255292 SDHC SDHD
2 hormone activity GO:0005179 9.43 CALCA EPO INS
3 ferrous iron binding GO:0008198 9.37 EGLN1 TF
4 electron transfer activity GO:0009055 9.33 SDHB SDHC SDHD
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.13 SDHB SDHC SDHD
6 ubiquinone binding GO:0048039 8.92 ENSG00000255292 SDHB SDHC SDHD

Sources for Plethora of Newborn

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....