MCID: PLT001
MIFTS: 27

Plethora of Newborn

Categories: Blood diseases

Aliases & Classifications for Plethora of Newborn

MalaCards integrated aliases for Plethora of Newborn:

Name: Plethora of Newborn 12 15
Neonatal Polycythemia 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:11242
ICD9CM 34 776.4
NCIt 50 C27069
SNOMED-CT 67 32984002
ICD10 32 P61.1
UMLS 70 C0272153

Summaries for Plethora of Newborn

MalaCards based summary : Plethora of Newborn, also known as neonatal polycythemia, is related to polycythemia and hypoglycemia. An important gene associated with Plethora of Newborn is EPO (Erythropoietin), and among its related pathways/superpathways are Pathways in cancer and Citrate cycle (TCA cycle). Affiliated tissues include brain, liver and pancreas, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Plethora of Newborn

Diseases related to Plethora of Newborn via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 polycythemia 31.0 EPO EPAS1 EGLN1
2 hypoglycemia 10.2
3 chronic mountain sickness 10.1 EPO EPAS1
4 duodenal somatostatinoma 10.1 EPAS1 EGLN1
5 erythrocytosis, familial, 4 10.1 EPAS1 EGLN1
6 erythrocytosis, familial, 1 10.1 EPO EGLN1
7 parathyroid gland disease 10.1 EPO EGLN1
8 ichthyosis, congenital, autosomal recessive 11 10.0 EPAS1 EGLN1
9 familial isolated hypoparathyroidism 10.0 EPO EGLN1
10 hemangioblastoma 10.0 EPO EPAS1
11 enterocolitis 10.0
12 cyanosis, transient neonatal 10.0
13 gestational diabetes 10.0
14 thrombocytopenia 10.0
15 perinatal necrotizing enterocolitis 10.0
16 47,xyy 10.0
17 48,xyyy 10.0
18 autosomal dominant secondary polycythemia 9.9 EPO EPAS1 EGLN1
19 acquired polycythemia 9.9 EPO EPAS1 EGLN1
20 primary polycythemia 9.9 EPO EPAS1 EGLN1
21 erythrocytosis, familial, 2 9.9 EPO EPAS1 EGLN1
22 neural crest tumor 9.9 SDHD SDHB
23 gastric leiomyosarcoma 9.9 SDHD SDHB
24 paragangliomas 1 9.9 SDHD SDHB
25 cerebellar angioblastoma 9.8 SDHD SDHB
26 extra-adrenal pheochromocytoma 9.8 SDHD SDHB
27 carney triad 9.8 SDHD SDHB
28 cranial nerve palsy 9.8 SDHD SDHB
29 adrenal medulla cancer 9.8 SDHD SDHB
30 autonomic nervous system benign neoplasm 9.8 SDHD SDHB
31 peripheral nervous system benign neoplasm 9.8 SDHD SDHB
32 chondroma 9.8 SDHD SDHB
33 multiple endocrine neoplasia, type i 9.8 SDHD SDHB
34 multiple endocrine neoplasia, type iib 9.8 SDHD SDHB
35 hyperphosphatemia 9.8
36 spastic quadriplegia 9.8
37 quadriplegia 9.8
38 persistent fetal circulation syndrome 9.8
39 gonadal dysgenesis 9.8
40 cerebral palsy 9.8
41 hyperinsulinism 9.8
42 neonatal jaundice 9.8
43 bilirubin metabolic disorder 9.8
44 placental insufficiency 9.8
45 endophthalmitis 9.8
46 eisenmenger syndrome 9.8
47 hypotonia 9.8
48 multiple endocrine neoplasia 9.8 SDHD SDHB
49 glomus tumor 9.8 SDHD SDHB
50 mitochondrial complex ii deficiency, nuclear type 1 9.8 SDHD SDHB

Graphical network of the top 20 diseases related to Plethora of Newborn:



Diseases related to Plethora of Newborn

Symptoms & Phenotypes for Plethora of Newborn

MGI Mouse Phenotypes related to Plethora of Newborn:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 EGLN1 EPAS1 EPO F8 SDHB SDHD
2 homeostasis/metabolism MP:0005376 9.17 EGLN1 EPAS1 EPO F8 S100G SDHB

Drugs & Therapeutics for Plethora of Newborn

Search Clinical Trials , NIH Clinical Center for Plethora of Newborn

Genetic Tests for Plethora of Newborn

Anatomical Context for Plethora of Newborn

MalaCards organs/tissues related to Plethora of Newborn:

40
Brain, Liver, Pancreas

Publications for Plethora of Newborn

Articles related to Plethora of Newborn:

(show top 50) (show all 100)
# Title Authors PMID Year
1
Timing of umbilical cord clamping and neonatal jaundice in singleton term pregnancy. 61
31927308 2020
2
Neonatal Polycythemia and Hypoglycemia in Newborns: Are They Related? 61
32028531 2020
3
Transfusion Medicine Equations Made Internet Accessible. 61
31785949 2020
4
Macular hemorrhages associated with neonatal polycythemia and thrombocytopenia: A case report. 61
28041861 2017
5
Increased Proportion of Hematopoietic Stem and Progenitor Cell Population in Cord Blood of Neonates Born to Mothers with Gestational Diabetes Mellitus. 61
26494027 2016
6
Choosing the Best Newborn Anthropometric Measure Associated With the Risks and Outcomes of Intrauterine Growth Restriction. 61
25854788 2015
7
First report of bilateral pheochromocytoma in the clinical spectrum of HIF2A-related polycythemia-paraganglioma syndrome. 61
23539726 2013
8
Restrictive management of neonatal polycythemia. 61
21667428 2011
9
[Clinical characteristics and changes in blood electrolyte and renal function of neonates with polycythemia at high altitude]. 61
22321189 2011
10
Partial exchange transfusion to prevent neurodevelopmental disability in infants with polycythemia. 61
20091569 2010
11
Does polycythemia affect interleukin-6 response pattern in early postnatal period? 61
20872570 2010
12
The effect of early and late umbilical cord clamping on neonatal hematocrit. 61
18596716 2008
13
Neonatal polycythemia and hyperviscosity. 61
18424246 2008
14
Increased energy expenditure after dilutional exchange transfusion for neonatal polycythemia. 61
17914128 2007
15
[Relationship between neonatal polycythemia and brain damage]. 61
17274876 2006
16
Crystalloid or colloid for partial exchange transfusion in neonatal polycythemia: a systematic review and meta-analysis. 61
16303705 2005
17
Neonatal polycythemia: is partial exchange transfusion justified? 61
15325537 2004
18
Differential diagnosis and management of polycythemia. 61
15275989 2004
19
[Neonatal Doppler velocimetry in full term small-for-gestational age newborns]. 61
14595488 2003
20
Polycythemia in the newborn. 61
12840689 2003
21
Early cord clamping protects at-risk neonates from polycythemia. 61
12660438 2003
22
Nucleated red blood cells in polycythemic infants. 61
12548216 2003
23
Maternal smoking and partial exchange transfusion for neonatal polycythemia. 61
12442223 2002
24
Neonatal polycythemia. 61
11802122 2002
25
Fumaric aciduria: clinical and imaging features. 61
10805328 2000
26
Neonatal polycythemia: effects of partial exchange transfusion using fresh frozen plasma, Haemaccel and normal saline. 61
10730524 1999
27
Pregnancy complications and neonatal outcomes in multifetal pregnancies reduced to twins compared with nonreduced twin pregnancies. 61
10355912 1999
28
[Neonatal polycythemia: risk of microcirculation disorders]. 61
10540579 1999
29
Neonatal polycythemia. 61
10771885 1997
30
[Advances in the study of neonatal polycythemia]. 61
9387519 1996
31
Symptomatic neonatal polycythemia: comparison of partial exchange transfusion with saline versus plasma. 61
8772864 1995
32
Neonatal polycythemia and hyperviscosity. 61
8521689 1995
33
Developmental outcome of infants with neonatal polycythemia. 61
7798839 1994
34
Neonatal polycythemia and maternal hypertension. 61
8193483 1994
35
Elevated erythropoietin levels in cord blood of newborns with Down's syndrome. 61
7948440 1994
36
Postnatal development of liver and exocrine pancreas in polycythemic newborn infants. 61
1432470 1992
37
Neonatal polycythemia in appropriately grown infants of hypertensive mothers. 61
1421903 1992
38
Effects of neonatal polycythemia and hemodilution on capillary perfusion. 61
1625066 1992
39
Neonatal hematocrit and maternal glycemic control in insulin-dependent diabetes. 61
1735833 1992
40
Polycythemia of the preterm and full-term newborn infant: relationship between hematocrit and gestational age, total blood solutes, reticulocyte count, and blood pH. 61
1610945 1992
41
Neonatal polycythemia--issues and current perspectives. 61
2094665 1990
42
Diagnostic value of arterial hematocrits in neonatal polycythemia. 61
2275370 1990
43
Cord transferrin and ferritin values for erythropoiesis in newborn infants of diabetic mothers. 61
2633911 1989
44
Effects of prolonged hyperinsulinemia on erythropoiesis in fetal sheep. 61
2511768 1989
45
Diagnostic errors in neonatal polycythemia based on method of hematocrit determination. 61
2769507 1989
46
Pathogenesis of hypocalcemia in neonatal polycythemia. 61
2796808 1989
47
The association between neonatal polycythemia, hypocalcemia, and hypoglycemia. 61
2812827 1989
48
Neonatal hyperviscosity association with lower achievement and IQ scores at school age. 61
2717281 1989
49
[Neurologic follow-up of polycythemic newborn infants]. 61
2719811 1989
50
[Neonatal polycythemia. Review of 110 cases]. 61
3251326 1988

Variations for Plethora of Newborn

Expression for Plethora of Newborn

Search GEO for disease gene expression data for Plethora of Newborn.

Pathways for Plethora of Newborn

GO Terms for Plethora of Newborn

Cellular components related to Plethora of Newborn according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.62 SDHD SDHB

Biological processes related to Plethora of Newborn according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.46 SDHD SDHB F8 EGLN1
2 erythrocyte differentiation GO:0030218 9.37 EPO EPAS1
3 acute-phase response GO:0006953 9.32 F8 EPO
4 tricarboxylic acid cycle GO:0006099 9.26 SDHD SDHB
5 response to hypoxia GO:0001666 9.13 EPO EPAS1 EGLN1
6 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 8.8 EPO EPAS1 EGLN1

Molecular functions related to Plethora of Newborn according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 8.96 SDHD SDHB
2 ubiquinone binding GO:0048039 8.62 SDHD SDHB

Sources for Plethora of Newborn

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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