MCID: PLT001
MIFTS: 36

Plethora of Newborn

Categories: Blood diseases

Aliases & Classifications for Plethora of Newborn

MalaCards integrated aliases for Plethora of Newborn:

Name: Plethora of Newborn 12 15
Neonatal Polycythemia 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11242
ICD9CM 36 776.4
NCIt 51 C27069
SNOMED-CT 69 32984002 9170001
ICD10 34 P61.1
UMLS 74 C0272153

Summaries for Plethora of Newborn

MalaCards based summary : Plethora of Newborn, also known as neonatal polycythemia, is related to polycythemia and glomus tumor. An important gene associated with Plethora of Newborn is PSMA7 (Proteasome Subunit Alpha 7), and among its related pathways/superpathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Carbon metabolism. The drugs Dinoprostone and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include kidney, lymph node and thyroid, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Plethora of Newborn

Diseases related to Plethora of Newborn via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 polycythemia 31.1 EGLN1 EPAS1 EPO
2 glomus tumor 10.1 SDHB SDHD
3 hypoxia 10.1 EGLN1 EPAS1 PSMA7
4 autosomal dominant secondary polycythemia 10.1 EGLN1 EPAS1 EPO
5 erythrocytosis, familial, 2 10.1 EGLN1 EPAS1 EPO
6 neural crest tumor 10.0 SDHB SDHC SDHD
7 extra-adrenal pheochromocytoma 10.0 SDHB SDHC SDHD
8 paraganglioma 10.0 SDHB SDHC SDHD
9 paragangliomas 1 10.0 SDHB SDHC SDHD
10 adrenal medulla cancer 10.0 SDHB SDHC SDHD
11 chondroma 10.0 SDHB SDHC SDHD
12 paraganglioma and gastric stromal sarcoma 10.0 SDHB SDHC SDHD
13 carney triad 10.0 SDHB SDHC SDHD
14 primary polycythemia 10.0 EGLN1 EPO
15 hereditary paraganglioma-pheochromocytoma syndromes 10.0 SDHB SDHC SDHD
16 mitochondrial complex ii deficiency 10.0 SDHB SDHC SDHD
17 neurofibromatosis, type iv, of riccardi 10.0 SDHB SDHC SDHD
18 von hippel-lindau syndrome 10.0 SDHB SDHC SDHD
19 gastrointestinal stromal tumor 10.0 SDHB SDHC SDHD
20 malignant pheochromocytoma 9.9 CALCA SDHB
21 thrombocytopenia 9.9
22 secondary hyperparathyroidism of renal origin 9.9 CALCA EPO
23 cloacogenic carcinoma 9.9 CALCA PTPRC
24 sheehan syndrome 9.9 EPO INS
25 multiple endocrine neoplasia 9.9 CALCA SDHB SDHC
26 persistent generalized lymphadenopathy 9.9 EPAS1 SDHB SDHC SDHD
27 diabetic autonomic neuropathy 9.9 EPO INS
28 sporadic pheochromocytoma 9.9 EPAS1 SDHB SDHC SDHD
29 multiple endocrine neoplasia, type iia 9.8 CALCA SDHB SDHD
30 fetal erythroblastosis 9.8 EPO INS
31 duodenal somatostatinoma 9.8 CALCA INS
32 persistent fetal circulation syndrome 9.8
33 hypoglycemia 9.8
34 eisenmenger syndrome 9.8
35 lymph node disease 9.7 PGLS SDHB SDHC SDHD
36 lymphatic system disease 9.7 PGLS SDHB SDHC SDHD
37 autonomic nervous system disease 9.7 CALCA INS
38 multiple endocrine neoplasia, type i 9.7 INS SDHB SDHD
39 autosomal genetic disease 9.7 INS SDHB SDHD
40 islet cell tumor 9.7 CALCA INS
41 somatostatinoma 9.6 CALCA EPAS1 INS
42 small cell carcinoma 9.6 CALCA PTPRC
43 thyroid gland disease 9.6 CALCA INS
44 chronic kidney failure 9.5 CALCA EPO INS
45 pheochromocytoma 9.5 CALCA EPAS1 SDHB SDHC SDHD
46 endocrine organ benign neoplasm 8.9 CALCA INS PGLS SDHB SDHC SDHD

Graphical network of the top 20 diseases related to Plethora of Newborn:



Diseases related to Plethora of Newborn

Symptoms & Phenotypes for Plethora of Newborn

MGI Mouse Phenotypes related to Plethora of Newborn:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 EGLN1 EPAS1 EPO INS PTPRC SDHB
2 homeostasis/metabolism MP:0005376 9.86 EGLN1 EPAS1 EPO INS PTPRC SDHB
3 mortality/aging MP:0010768 9.56 EGLN1 EPAS1 EPO INS PTPRC SDHB
4 liver/biliary system MP:0005370 9.55 EGLN1 EPAS1 EPO INS PTPRC
5 skeleton MP:0005390 9.1 EGLN1 EPAS1 EPO INS PTPRC SDHC

Drugs & Therapeutics for Plethora of Newborn

Drugs for Plethora of Newborn (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dinoprostone Approved Not Applicable 363-24-6 5280360
2
Oxytocin Approved, Vet_approved Not Applicable 50-56-6 53477758 439302
3
Iron Approved, Experimental Not Applicable 7439-89-6, 15438-31-0 27284 23925
4 Trace Elements Not Applicable
5 Ferric Oxide, Saccharated Not Applicable
6 Hematinics Not Applicable
7 Micronutrients Not Applicable
8 Nutrients Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gestational Diabetes: Induction Versus Expectant Management of Labour Completed NCT01058772 Not Applicable
2 Pregnancy Outcomes and Medical Costs According to Gestational Diabetes Mellitus Diagnostic Criteria Recruiting NCT03421262 Not Applicable
3 The Effect of Oral Probiotics on Glycemic Control of Women With Gestational Diabetes Mellitus Not yet recruiting NCT03864549 Not Applicable
4 To Compare the Efficacy of I.V 200 mg Iron Sucrose and 500 mg Iron Sucrose to Treat Anemia in Pregnancy Not yet recruiting NCT02441439 Not Applicable

Search NIH Clinical Center for Plethora of Newborn

Genetic Tests for Plethora of Newborn

Anatomical Context for Plethora of Newborn

MalaCards organs/tissues related to Plethora of Newborn:

42
Kidney, Lymph Node, Thyroid

Publications for Plethora of Newborn

Articles related to Plethora of Newborn:

(show top 50) (show all 53)
# Title Authors Year
1
Macular hemorrhages associated with neonatal polycythemia and thrombocytopenia: A case report. ( 28041861 )
2017
2
Restrictive management of neonatal polycythemia. ( 21667428 )
2011
3
Neonatal polycythemia and hyperviscosity. ( 18424246 )
2008
4
Increased energy expenditure after dilutional exchange transfusion for neonatal polycythemia. ( 17914128 )
2007
5
Crystalloid or colloid for partial exchange transfusion in neonatal polycythemia: a systematic review and meta-analysis. ( 16303705 )
2005
6
Neonatal polycythemia: is partial exchange transfusion justified? ( 15325537 )
2004
7
Maternal smoking and partial exchange transfusion for neonatal polycythemia. ( 12442223 )
2002
8
Neonatal polycythemia. ( 11802122 )
2002
9
Neonatal polycythemia: effects of partial exchange transfusion using fresh frozen plasma, Haemaccel and normal saline. ( 10730524 )
1999
10
Neonatal polycythemia. ( 10771885 )
1997
11
Neonatal polycythemia and hyperviscosity. ( 8521689 )
1995
12
Symptomatic neonatal polycythemia: comparison of partial exchange transfusion with saline versus plasma. ( 8772864 )
1995
13
Developmental outcome of infants with neonatal polycythemia. ( 7798839 )
1994
14
Neonatal polycythemia and maternal hypertension. ( 8193483 )
1994
15
Neonatal polycythemia in appropriately grown infants of hypertensive mothers. ( 1421903 )
1992
16
Effects of neonatal polycythemia and hemodilution on capillary perfusion. ( 1625066 )
1992
17
Neonatal polycythemia--issues and current perspectives. ( 2094665 )
1990
18
Diagnostic value of arterial hematocrits in neonatal polycythemia. ( 2275370 )
1990
19
Diagnostic errors in neonatal polycythemia based on method of hematocrit determination. ( 2769507 )
1989
20
Pathogenesis of hypocalcemia in neonatal polycythemia. ( 2796808 )
1989
21
The association between neonatal polycythemia, hypocalcemia, and hypoglycemia. ( 2812827 )
1989
22
Hemodynamic consequences of neonatal polycythemia. ( 3819947 )
1987
23
Partial plasma exchange transfusion improves cerebral hemodynamics in symptomatic neonatal polycythemia. ( 3953635 )
1986
24
Left ventricular function in normal newborn infants and asymptomatic infants with neonatal polycythemia. ( 3751864 )
1986
25
Neonatal polycythemia in infants of insulin-dependent diabetic mothers. ( 3737061 )
1986
26
Neonatal polycythemia: frequency of clinical manifestations and other associated findings. ( 3725498 )
1986
27
Neonatal polycythemia and hyperviscosity. ( 3714337 )
1986
28
Neonatal polycythemia. ( 3511518 )
1986
29
Effects of neonatal polycythemia and partial exchange transfusion on cardiac function: an echocardiographic study. ( 4069859 )
1985
30
Neonatal polycythemia in Hawaii. ( 6511389 )
1984
31
Neonatal polycythemia. ( 6702518 )
1984
32
Neonatal polycythemia: I. Early diagnosis and incidence relating to time of sampling. ( 6691043 )
1984
33
Neonatal polycythemia: II. Definition related to time of sampling. ( 6691031 )
1984
34
Peripheral venous partial exchange transfusions for neonatal polycythemia. ( 6848290 )
1983
35
Body water estimates in neonatal polycythemia. ( 6848708 )
1983
36
Serum erythropoietin levels in neonatal polycythemia. ( 6674257 )
1983
37
Incidence of neonatal polycythemia. ( 6643026 )
1983
38
Neonatal polycythemia--a potentially serious disorder. ( 6618574 )
1983
39
Eisenmenger syndrome in pregnancy: a possible cause of neonatal polycythemia and persistent fetal circulation. ( 7145258 )
1982
40
Normal coagulation findings, thrombocytopenia, and peripheral hemoconcentration in neonatal polycythemia. ( 7086629 )
1982
41
Neonatal polycythemia. ( 7088623 )
1982
42
Neonatal polycythemia and hyperviscosity. ( 7133792 )
1982
43
Neonatal polycythemia: II. Plasma, blood and red cell volume estimates in relation to hematocrit levels and quality of intrauterine growth. ( 7196569 )
1981
44
Neonatal polycythemia and the hyperviscosity syndrome. ( 7233966 )
1981
45
Neonatal polycythemia: I. Criteria for diagnosis and treatment. ( 7267222 )
1981
46
Neonatal polycythemia causing multiple cerebral infarcts. ( 7356402 )
1980
47
Neonatal polycythemia and chest roentgenograms. ( 143365 )
1977
48
Neonatal polycythemia in low birthweight infant. ( 1000018 )
1976
49
Neonatal polycythemia hyperviscosity syndrome. ( 237826 )
1975
50
Neonatal polycythemia (case report). ( 4417955 )
1974

Variations for Plethora of Newborn

Expression for Plethora of Newborn

Search GEO for disease gene expression data for Plethora of Newborn.

Pathways for Plethora of Newborn

GO Terms for Plethora of Newborn

Cellular components related to Plethora of Newborn according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
2 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Plethora of Newborn according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.81 EGLN1 SDHB SDHC SDHD
2 response to hypoxia GO:0001666 9.54 EGLN1 EPAS1 EPO
3 erythrocyte differentiation GO:0030218 9.49 EPAS1 EPO
4 embryo implantation GO:0007566 9.48 CALCA EPO
5 acute-phase response GO:0006953 9.46 EPO INS
6 aerobic respiration GO:0009060 9.43 SDHB SDHC
7 leukocyte cell-cell adhesion GO:0007159 9.4 CALCA PTPRC
8 positive regulation of blood vessel diameter GO:0097755 9.32 CALCA INS
9 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.26 SDHC SDHD
10 negative regulation of calcium ion transport into cytosol GO:0010523 9.16 CALCA EPO
11 tricarboxylic acid cycle GO:0006099 9.13 SDHB SDHC SDHD
12 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 8.8 EGLN1 EPAS1 EPO

Molecular functions related to Plethora of Newborn according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 CALCA EPO INS
2 electron transfer activity GO:0009055 9.33 SDHB SDHC SDHD
3 ubiquinone binding GO:0048039 8.96 SDHB SDHD
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.8 SDHB SDHC SDHD

Sources for Plethora of Newborn

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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