MCID: PLR006
MIFTS: 38

Pleural Cancer

Categories: Cancer diseases

Aliases & Classifications for Pleural Cancer

MalaCards integrated aliases for Pleural Cancer:

Name: Pleural Cancer 12 15
Pleural Neoplasms 43 71
Malignant Tumor of Pleura 71
Neoplasm of Pleura 12
Pleural Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5158
ICD9CM 34 163
MeSH 43 D010997
NCIt 49 C3332 C3547
SNOMED-CT 67 126719004 363433009
ICD10 32 C38.4
UMLS 71 C0032229 C0153494

Summaries for Pleural Cancer

Disease Ontology : 12 A connective tissue cancer that located in the pleura.

MalaCards based summary : Pleural Cancer, also known as pleural neoplasms, is related to malignant pleural mesothelioma and mesothelioma, malignant. An important gene associated with Pleural Cancer is MUC16 (Mucin 16, Cell Surface Associated), and among its related pathways/superpathways is MicroRNAs in cancer. The drugs Pemetrexed and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include pleura, lung and prostate.

Related Diseases for Pleural Cancer

Diseases related to Pleural Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)
# Related Disease Score Top Affiliating Genes
1 malignant pleural mesothelioma 32.4 NF2 MSLN MIR625 MIR411 MIR223 MIR17
2 mesothelioma, malignant 30.1 NF2 MUC16 MSLN MIR625 CALB2 BAP1
3 kidney cancer 29.9 MIR29C MIR185 MIR17 H2AC18
4 hepatocellular carcinoma 29.0 MIRLET7A1 MIR93 MIR30E MIR29C MIR223 MIR185
5 renal cell carcinoma, nonpapillary 28.9 MSLN MIRLET7A1 MIR93 MIR30E MIR29C MIR185
6 pleural disease 28.7 NF2 MSLN MIRLET7A1 MIR625 MIR411 MIR32
7 lung cancer susceptibility 3 28.6 MUC16 MSLN MIRLET7A1 MIR625 MIR411 MIR32
8 malignant pleural solitary fibrous tumor 11.2
9 pseudo-meigs syndrome 10.6 MUC16 CALB2
10 liver fibroma 10.6 MSLN CALB2
11 malignant biphasic mesothelioma 10.6 MSLN CALB2
12 cystadenofibroma 10.6 MUC16 CALB2
13 pericardium cancer 10.6 MSLN CALB2
14 adenofibroma 10.5 MUC16 CALB2
15 purulent labyrinthitis 10.5 NF2 MIRLET7A1
16 ovarian cystadenocarcinoma 10.5 MUC16 MIR17 CALB2
17 papillary serous adenocarcinoma 10.5 MIR625 MIR30E CALB2
18 malignant peritoneal mesothelioma 10.5 NF2 BAP1
19 pericardial mesothelioma 10.5 MUC16 MIR32 MIR17 CALB2
20 angiomatous meningioma 10.5 NF2 BAP1
21 bladder carcinoma in situ 10.5 MIR142 MIR139
22 sarcomatoid mesothelioma 10.5 MSLN CALB2 BAP1
23 extrinsic cardiomyopathy 10.5 MIR223 MIR142 H2AC18
24 fallopian tube endometrioid adenocarcinoma 10.5 MUC16 CALB2
25 infratentorial cancer 10.5 MIR17 MIR142 H2AC18
26 leiomyoma, uterine 10.5 MUC16 MIR32 MIR29C MIR139
27 retinal cancer 10.4 MIR17 MIR142 H2AC18
28 bronchial disease 10.4 MIR17 MIR142 H2AC18
29 sezary's disease 10.4 MIRLET7A1 MIR223 MIR17
30 bone resorption disease 10.4 MIR93 MIR142 H2AC18
31 spinal cord disease 10.4 NF2 MIR142 H2AC18
32 thyroid gland disease 10.4 MIR17 MIR142 MIR138-1 H2AC18
33 bone remodeling disease 10.4 MIR93 MIR142 H2AC18
34 uveal disease 10.4 MIR142 H2AC18 BAP1
35 mucinous stomach adenocarcinoma 10.4 NF2 CALB2
36 bone sarcoma 10.4 MIR17 MIR142 H2AC18
37 rectum cancer 10.4 MIRLET7A1 MIR625 MIR17 MIR139
38 bile duct adenocarcinoma 10.4 MIR30E MIR17 MIR142 H2AC18
39 bone inflammation disease 10.4 MIR223 MIR17 MIR142 H2AC18
40 rhabdoid meningioma 10.4 NF2 BAP1
41 x-linked recessive disease 10.4 MIR223 MIR142 H2AC18
42 bone marrow cancer 10.4 MIR30E MIR17 MIR142 H2AC18
43 mature b-cell neoplasm 10.4 MIR185 MIR17 MIR142 H2AC18
44 primary bacterial infectious disease 10.4 MIR93 MIR223 MIR142 H2AC18
45 chromosomal deletion syndrome 10.4 MIR185 MIR17 MIR142 H2AC18
46 tongue disease 10.4 MIR185 MIR17 MIR139 MIR138-1
47 pre-malignant neoplasm 10.4 MIR17 MIR142 MIR139 H2AC18
48 in situ carcinoma 10.4 MIR17 MIR142 MIR139 H2AC18
49 intestinal benign neoplasm 10.4 MIR17 MIR142 MIR139 H2AC18
50 benign peritoneal mesothelioma 10.4 MSLN CALB2

Comorbidity relations with Pleural Cancer via Phenotypic Disease Network (PDN):


Deficiency Anemia

Graphical network of the top 20 diseases related to Pleural Cancer:



Diseases related to Pleural Cancer

Symptoms & Phenotypes for Pleural Cancer

Drugs & Therapeutics for Pleural Cancer

Drugs for Pleural Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pemetrexed Approved, Investigational Phase 2 137281-23-3, 150399-23-8 60843 446556
2
leucovorin Approved Phase 2 58-05-9 6006 143
3
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
4
Durvalumab Approved, Investigational Phase 2 1428935-60-7
5
nivolumab Approved Phase 2 946414-94-4
6
Aminolevulinic acid Approved Phase 2 106-60-5 137
7
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
8
Tremelimumab Investigational Phase 2 745013-59-6
9 Vitamin B Complex Phase 2
10 Folic Acid Antagonists Phase 2
11 Folate Phase 2
12 Vitamin B9 Phase 2
13 Protein Kinase Inhibitors Phase 2
14 Imatinib Mesylate Phase 2 220127-57-1 123596
15 Photosensitizing Agents Phase 2
16 Antineoplastic Agents, Immunological Phase 2
17
afatinib Approved Phase 1 439081-18-2, 850140-72-6 10184653
18
Dasatinib Approved, Investigational Phase 1 302962-49-8 3062316
19
Tyrosine Approved, Investigational, Nutraceutical Phase 1 60-18-4 6057
20 Mitogens Phase 1
21
Imidazole Experimental, Investigational 288-32-4 795
22
Etanidazole Investigational 22668-01-5
23 Immunoglobulins
24 Antibodies

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Pilot Study of the Safety, Efficacy, and Side Effects of Interventional Cryotherapy for the Eradication of Disease in the Pleural Space ("ICE PLS") Terminated NCT00747916 Phase 4
2 A Multicenter Phase II Trial of Neo-Adjuvant Pemetrexed (Alimta) Plus Cisplatin Followed by Surgery and Radiation for Pleural Mesothelioma Completed NCT00087698 Phase 2 pemetrexed;cisplatin
3 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
4 Window Of Opportunity Phase II Study Of MEDI4736 Or MEDI4736 + Tremelimumab In Surgically Resectable Malignant Pleural Mesothelioma Active, not recruiting NCT02592551 Phase 2 MEDI4736;Tremelimumab
5 Intrapleural Photodynamic Therapy by Video-Assisted Thoracoscopy Followed by Anti-PD-1 NIVOLUMAB in Patients With Malignant Pleural Mesothelioma - a Pilot Study Not yet recruiting NCT04400539 Phase 2 Nivolumab Injection
6 Phase I Trial Evaluating Safety and Tolerability of the Irreversible Epidermal Growth Factor Receptor Inhibitor Afatinib (BIBW 2992) in Combination With the SRC Kinase Inhibitor Dasatinib for Patients With Non-small Cell Lung Cancer (NSCLC) Completed NCT01999985 Phase 1 Dasatinib - 1A;Afatinib - 1A;Dasatinib - 1B;Afatinib - 1B
7 Epidemiology and Outcome of Solitary Fibrous Tumors of the Pleura. A Multicenter Study. Unknown status NCT01694654
8 Detection and Characterization of Circulating Tumor Cells in Patients With Malignant Pleural Mesothelioma: Towards a New Phase in the Understanding of the Natural History of This Cancer? Completed NCT01776385
9 Preoperative Oncogeriatric Assessment for Thoracic Malignancies Completed NCT00591981
10 Staging Procedures to Diagnose Malignant Pleural Mesothelioma Recruiting NCT02648763
11 Surgery for Mesothelioma After Radiation Therapy "SMART" for Resectable Malignant Pleural Mesothelioma Recruiting NCT02613299
12 Detection of Clusters of Volatile Organic Compounds (VOC)in Patients With Different Lung Disorders by Ion Mobility Spectrometry. Different Clusters of VOC in the Diagnosis of Different Lung Disorders Using Ion Mobility Spectrometry Recruiting NCT00632307
13 Chemotherapy Followed by Surgery and Neoadjuvant Hemothoracic Intensity Modified Radiation Therapy (IMRT) for Patients With Malignant Pleural Mesothelioma Recruiting NCT02613312
14 Liquid Biopsy With Immunomagnetic Beads Capture Technique for Malignant Cell Detection in Body Fluid Recruiting NCT02891642
15 Activity Behaviours in Patients With Malignant Pleural Effusion: Relationships With Quality of Life, and Respiratory Symptoms, and Survival Recruiting NCT03482570
16 The Detection of Tumor Hypoxia and Vascularity in Patients Undergoing Intraperitoneal Photodynamic Therapy Terminated NCT00028782 etanidazole
17 Evaluation of Multiple Biomarkers in Serum and Pleural Fluid to Estimate the Probability of Cancer in Patients Presenting With an Undiagnosed Pleural Effusion Terminated NCT00316134
18 Optical Coherence Tomography for Early Detection and Staging of Endobronchial Lung and Pleural Cancer, Airway Injury, and Prostate Cancer Withdrawn NCT00581503

Search NIH Clinical Center for Pleural Cancer

Cochrane evidence based reviews: pleural neoplasms

Genetic Tests for Pleural Cancer

Anatomical Context for Pleural Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Pleural Cancer:

19
Pleura

MalaCards organs/tissues related to Pleural Cancer:

40
Lung, Prostate, Heart, Smooth Muscle, Kidney, Testes, T Cells

Publications for Pleural Cancer

Articles related to Pleural Cancer:

(show top 50) (show all 238)
# Title Authors PMID Year
1
Association between proximity to industrial chemical installations and cancer mortality in Spain. 61
31991345 2020
2
Relative burden of lung and pleural cancers from exposure to asbestos: a cross-sectional analysis of occupational mortality in England and Wales. 61
32273321 2020
3
Mortality and mesothelioma incidence among chrysotile asbestos miners in Balangero, Italy: A cohort study. 61
31821579 2020
4
Role of asbestos clearance in explaining long-term risk of pleural and peritoneal cancer: a pooled analysis of cohort studies. 61
31413184 2019
5
Quantitative relationships of exposure to chrysotile asbestos and mesothelioma mortality. 61
31087402 2019
6
Mortality for Mesothelioma and Lung Cancer in a Cohort of Asbestos Cement Workers in BARI (Italy): Time Related Aspects of Exposure. 61
30870398 2019
7
Occupational exposures to cosmetic talc and risk of mesothelioma: an updated pooled cohort and statistical power analysis with consideration of latency period. 61
31380702 2019
8
Extra-pleural pneumonectomy. 61
31019792 2019
9
Cancer risk in oil refinery workers: a pooled mortality study in Italy. 61
30794243 2019
10
Upcoming epidemic of asbestos-related malignant pleural mesothelioma in Taiwan: A prediction of incidence in the next 30 years. 61
30072200 2019
11
Ratio of carcinoembryonic antigen in pleural fluid and serum for the diagnosis of malignant pleural effusion. 61
31205509 2019
12
Mortality among workers exposed to asbestos at the shipyard of Genoa, Italy: a 55 years follow-up. 61
30594195 2018
13
International Analysis of Age-Specific Mortality Rates From Mesothelioma on the Basis of the International Classification of Diseases, 10th Revision. 61
30241199 2018
14
Immune-mediated Pericarditis With Pericardial Tamponade During Nivolumab Therapy. 61
29461982 2018
15
The Diagnosis of Pleural Tumors Other Than Mesothelioma. 61
30040453 2018
16
Transcervical videomediastino-thoracoscopy. 61
30345101 2018
17
MR Imaging of Pleural Neoplasms. 61
29613962 2018
18
[Health impact of asbestos fibres naturally occurring in Mount Pollino area (Basilicata Region, Southern Italy)]. 61
29774711 2018
19
Mortality in a cohort of asbestos-exposed workers undergoing health surveillance. 61
29701625 2018
20
Surgical therapy and next-generation sequencing-based genetic alteration analysis of malignant solitary fibrous tumor of the pleura. 61
30214228 2018
21
Histomorphological and Immunohistochemical Analysis of Pleural Neoplasms. 61
30697290 2018
22
Italian pool of asbestos workers cohorts: mortality trends of asbestos-related neoplasms after long time since first exposure. 61
28775133 2017
23
Chimeric Antigen Receptor (CAR) T Cell Therapy for Malignant Pleural Mesothelioma (MPM). 61
28862644 2017
24
Application of Immunohistochemistry in the Diagnosis of Pulmonary and Pleural Neoplasms. 61
28644685 2017
25
Mortality from cancer and other causes among Italian chrysotile asbestos miners. 61
28438787 2017
26
Mortality of Talc Miners and Millers From Val Chisone, Northern Italy: An Updated Cohort Study. 61
28691999 2017
27
A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ. 61
28387650 2017
28
Solitary Fibrous Tumor - Less Common Neoplasms of the Pleural Cavity. 61
28049955 2017
29
Malignant pleural fluid from mesothelioma has potent biological activities. 61
27560254 2017
30
Updated mortality study of a cohort of asbestos textile workers. 61
27457053 2016
31
[Pleural mesothelioma mortality in Italy: time series reconstruction (1970-2009) and comparison with incidence (2003-2008)]. 61
27436254 2016
32
Mortality (1968-2008) in a French cohort of uranium enrichment workers potentially exposed to rapidly soluble uranium compounds. 61
26655962 2016
33
Metachronous Malignant Solitary Fibrous Tumor of Kidney: Case Report and Review of Literature. 61
26793578 2016
34
Integrated therapeutic approach to giant solitary fibrous tumor of the pleura: report of a case and review of the literature. 61
28352798 2016
35
Imaging characteristics of pleural tumours. 61
26475741 2015
36
Hemorrhagic intramedullary solitary fibrous tumor of the conus medullaris: case report. 61
26115022 2015
37
Risk of cancer from occupational exposure to ionising radiation: retrospective cohort study of workers in France, the United Kingdom, and the United States (INWORKS). 61
26487649 2015
38
Survival patterns in lung and pleural cancer in Europe 1999-2007: Results from the EUROCARE-5 study. 61
26421826 2015
39
Pleural neoplastic pathology. 61
26048082 2015
40
Cancer incidence among 41,000 offshore oil industry workers. 61
25082833 2014
41
Spatial relationship quantification between environmental, socioeconomic and health data at different geographic levels. 61
24705362 2014
42
Retrospective cohort study of a microelectronics and business machine facility. 61
24375784 2014
43
A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids. 61
24496222 2014
44
Solitary fibrous tumor of the intrathoracic goiter. 61
25405117 2014
45
Positive FDG-PET/CT of the pleura twenty years after talc pleurodesis: three cases of benign talcoma. 61
24457915 2014
46
The fibres with fluoro-edenitic composition in Biancavilla (Sicily, Italy): health impact and clues for environmental remediation. 61
24968907 2014
47
Pleural cancer mortality in Spain: time-trends and updating of predictions up to 2020. 61
24195451 2013
48
A tailored, supportive care intervention using systematic assessment designed for people with inoperable lung cancer: a randomised controlled trial. 61
23733720 2013
49
Mortality among workers at Oak Ridge National Laboratory. 61
23460075 2013
50
Distribution and trends in mesothelioma mortality in Italy from 1974 to 2006. 61
22729565 2013

Variations for Pleural Cancer

Expression for Pleural Cancer

Search GEO for disease gene expression data for Pleural Cancer.

Pathways for Pleural Cancer

Pathways related to Pleural Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.66 MIRLET7A1 MIR625 MIR32 MIR30E MIR29C MIR223

GO Terms for Pleural Cancer

Cellular components related to Pleural Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 MUC16 MSLN MIRLET7A1 MIR93 MIR625 MIR411
2 extracellular vesicle GO:1903561 9.17 MIRLET7A1 MIR93 MIR411 MIR30E MIR29C MIR185

Biological processes related to Pleural Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.77 NF2 MIR93 MIR29C MIR138-1 BAP1
2 negative regulation of inflammatory response GO:0050728 9.67 MIR223 MIR142 MIR138-1
3 miRNA mediated inhibition of translation GO:0035278 9.58 MIRLET7A1 MIR17 MIR138-1
4 negative regulation of cell migration GO:0030336 9.56 NF2 MIR93 MIR29C MIR138-1
5 negative regulation of gene expression GO:0010629 9.55 MIR93 MIR29C MIR185 MIR17 MIR138-1
6 negative regulation of cell-matrix adhesion GO:0001953 9.48 NF2 MIR29C
7 response to inorganic substance GO:0010035 9.46 GART BAP1
8 gene silencing by miRNA GO:0035195 9.44 MIRLET7A1 MIR93 MIR625 MIR411 MIR32 MIR30E
9 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.43 MIR185 MIR17
10 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.32 MIR17 MIR138-1
11 negative regulation of sprouting angiogenesis GO:1903671 9.13 MIR30E MIR17 MIR138-1

Molecular functions related to Pleural Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.36 MIRLET7A1 MIR93 MIR411 MIR32 MIR30E MIR29C

Sources for Pleural Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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