Pleural Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PLR006 MIFTS: 41	Pleural Cancer Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Pleural Cancer

MalaCards integrated aliases for Pleural Cancer:

Name: Pleural Cancer ¹² ¹⁵

Pleural Neoplasms ⁴⁴ ⁷³

Malignant Tumor of Pleura ⁷³

Neoplasm of Pleura ¹²

Pleural Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Malignant neoplasms of respiratory and intrathoracic organs

Malignant neoplasm of heart, mediastinum and pleura

Malignant neoplasm: Pleura

External Ids:

Disease Ontology ¹² DOID:5158

ICD10 ³³ C38.4

ICD9CM ³⁵ 163 163.9

MeSH ⁴⁴ D010997

NCIt ⁵⁰ C3332 C3547

SNOMED-CT ⁶⁸ 93966009

UMLS ⁷³ C0032229 C0153494

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Summaries for Pleural Cancer

Disease Ontology : ¹² A connective tissue cancer that located in the pleura.

MalaCards based summary : Pleural Cancer, also known as pleural neoplasms, is related to pleural disease and malignant pleural mesothelioma. An important gene associated with Pleural Cancer is BAP1 (BRCA1 Associated Protein 1), and among its related pathways/superpathways is Glioblastoma Multiforme. The drugs Alimta and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and heart, and related phenotypes are behavior/neurological and immune system

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Related Diseases for Pleural Cancer

Diseases related to Pleural Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)

#	Related Disease	Score	Top Affiliating Genes
1	pleural disease	31.4	BAP1 CALB2 EFEMP1 MSLN SMUG1 SPP1
2	malignant pleural mesothelioma	30.7	BAP1 CALB2 CDKN2A EFEMP1 MSLN SPP1
3	benign mesothelioma	29.7	KRT5 WT1
4	corpus luteum cyst	10.3	MUC16 SMUG1
5	heart cancer	10.3	MUC16 SMUG1
6	rhabdoid meningioma	10.2	BAP1 NF2
7	malignant acrospiroma	10.2	KRT5 SMUG1
8	malignant spiradenoma	10.2	KRT5 SMUG1
9	inverted transitional papilloma	10.2	CDKN2A KRT5
10	malignant peritoneal mesothelioma	10.2	CDKN2A NF2
11	keratinizing squamous cell carcinoma	10.2	CDKN2A KRT5
12	fallopian tube squamous cell carcinoma	10.2	CDKN2A WT1
13	cornea cancer	10.2	CDKN2A NF2
14	pharynx squamous cell carcinoma	10.2	AKT1 SMUG1
15	atypical neurofibroma	10.2	CDKN2A NF2
16	prostate squamous cell carcinoma	10.2	KRT5 SMUG1
17	melanomatosis	10.2	CDKN2A WT1
18	anus cancer	10.2	CDKN2A KRT5 SMUG1
19	oropharynx cancer	10.1	CDKN2A KRT5 SMUG1
20	pseudo-meigs syndrome	10.1	CALB2 MUC16
21	sarcomatoid mesothelioma	10.1	CDKN2A WT1
22	optic nerve sheath meningioma	10.1	CDKN2A KRT5 NF2
23	anal canal squamous cell carcinoma	10.1	CDKN2A KRT5
24	optic nerve neoplasm	10.1	CDKN2A KRT5 NF2
25	fibrosarcomatous osteosarcoma	10.1	KRT5 SPP1
26	anal squamous cell carcinoma	10.1	AKT1 CDKN2A
27	peritoneum cancer	10.1	BAP1 KRT5 WT1
28	fallopian tube endometrioid adenocarcinoma	10.1	CALB2 CDKN2A
29	lymphoepithelioma-like thymic carcinoma	10.1	CD274 CDKN2A KRT5
30	adenofibroma	10.1	CALB2 MUC16
31	pharynx cancer	10.1	AKT1 CDKN2A SMUG1
32	papilloma	10.1	CDKN2A KRT5 TYMS
33	nasopharyngeal disease	10.1	AKT1 CDKN2A SMUG1
34	cervix disease	10.1	AKT1 CDKN2A SMUG1
35	lymphohistiocytoid mesothelioma	10.1	CALB2 CDKN2A
36	uterine anomalies	10.1	AKT1 CDKN2A SMUG1
37	breast giant fibroadenoma	10.1	CDKN2A WT1
38	female reproductive system disease	10.1	AKT1 CDKN2A SMUG1
39	reproductive system disease	10.1	AKT1 CDKN2A SMUG1
40	fallopian tube carcinosarcoma	10.1	CALB2 WT1
41	endocrine gland cancer	10.1	AKT1 CDKN2A SMUG1
42	central nervous system cancer	10.1	AKT1 CDKN2A NF2
43	nervous system cancer	10.1	AKT1 CDKN2A NF2
44	gastrointestinal system disease	10.1	AKT1 CDKN2A SMUG1
45	intestinal disease	10.1	AKT1 SMUG1 TYMS
46	respiratory system disease	10.0	AKT1 CD274 SMUG1
47	peritoneal benign neoplasm	10.0	CALB2 WT1
48	diffuse peritoneal leiomyomatosis	10.0	CALB2 WT1
49	peritoneal mesothelioma	10.0	BAP1 CDKN2A NF2 WT1
50	venous hemangioma	10.0	CALB2 WT1

Comorbidity relations with Pleural Cancer via Phenotypic Disease Network (PDN):

Deficiency Anemia

Graphical network of the top 20 diseases related to Pleural Cancer:

Sources

Symptoms & Phenotypes for Pleural Cancer

MGI Mouse Phenotypes related to Pleural Cancer:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.02	AKT1 ASS1 CALB2 CD274 CDKN2A EFEMP1
2	immune system	MP:0005387	9.97	AKT1 ASS1 BAP1 CD274 CDKN2A EFEMP1
3	integument	MP:0010771	9.91	AKT1 ASS1 BAP1 CD274 CDKN2A EFEMP1
4	mortality/aging	MP:0010768	9.7	AKT1 ASS1 BAP1 CD274 CDKN2A EFEMP1
5	liver/biliary system	MP:0005370	9.63	AKT1 CDKN2A EFEMP1 NF2 SPP1 WT1
6	neoplasm	MP:0002006	9.17	AKT1 BAP1 CDKN2A NF2 SMUG1 SPP1

Sources

Drugs & Therapeutics for Pleural Cancer

FDA approved drugs:

#	Drug Name	Active Ingredient(s) ¹⁸	Company	Approval Date
1	Alimta ¹⁸ ⁴⁹	PEMETREXED (also Pemetrexed Disodium)	Eli Lilly	February 2004
FDA Label: Alimta Disease/s that Drug Treats:Mesothelioma Indications and Usage: ¹⁸ ALIMTAÂ® is a folate analog metabolic inhibitor indicated for: Locally Advanced or Metastatic Nonsquamous Non-Small CellLung Cancer: Initial treatment in combination with cisplatin. (1.1) Maintenance treatment of patients whose disease has notprogressed after four cycles of platinum-based first-linechemotherapy. (1.2) After prior chemotherapy as a single-agent. (1.3) Mesothelioma: in combination with cisplatin. (1.4)Limitations of Use: ALIMTA is not indicated for the treatment of patients withsquamous cell non-small cell lung cancer. (1.5) DrugBank Targets: ¹⁶ 1. Thymidylate synthase;2. Bifunctional purine biosynthesis protein PURH;3. Dihydrofolate reductase;4. Trifunctional purine biosynthetic protein adenosine-3 Mechanism of Action: ¹⁸ Target: folic acid/ thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase Action: antagonist/ inhibitor FDA: ALIMTA, pemetrexed for injection, is a folate analog metabolic inhibitor that exerts its action by disrupting folatedependentmetabolic processes essential for cell replication. In vitro studies have shown that pemetrexed inhibitsthymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT),which are folate-dependent enzymes involved in the de novo biosynthesis of thymidine and purine nucleotides.Pemetrexed is taken into cells by membrane carriers such as the reduced folate carrier and membrane folate bindingprotein transport systems. Once in the cell, pemetrexed is converted to polyglutamate forms by the enzymefolylpolyglutamate synthetase. The polyglutamate forms are retained in cells and are inhibitors of TS and GARFT.Polyglutamation is a time- and concentration-dependent process that occurs in tumor cells and, is thought to occur to alesser extent, in normal tissues. Polyglutamated metabolites are thought to have an increased intracellular half-liferesulting in prolonged drug action in malignant cells.

Drugs for Pleural Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Hyaluronic acid

Approved, Vet_approved

9004-61-9

53477741

Cisplatin

Approved

15663-27-1

2767 441203 84093

Synonyms:

(SP-4-1)-diamminedichloridoplatinum

(SP-4-1)-diamminedichloroplatinum

(SP-4-2)-diamminedichloridoplatinum

(SP-4-2)-diamminedichloroplatinum

Abiplatin

Biocisplatinum

Briplatin

CACP

Carboquone

CDDP

CHEBI:35852

CID441203

Cis Pt II

cis-[PtCl2(NH3)2]

cis-DDP

Cis-DDP

Cis-Diaminedichloroplatinum

cis-diamminedichloridoplatinum(II)

cis-Diamminedichloroplatinum

Cis-Diamminedichloroplatinum

cis-diamminedichloroplatinum(II)

cis-Dichlorodiammineplatinum(II)

Cismaplat

Cisplatine

cisplatino

Cisplatino

Cisplatinum

Cisplatyl

Citoplationo

CPD0-1392

CPDC

CPDD

DB00515

DDP

DDPT

Diamminedichloroplatinum

EU-0100918

Lederplatin

nchembio773-comp1

Neoplatin

Peyrone's chloride

Peyrone's salt

Plastin

Platamine

Platiblastin

Platidiam

Platinex

Platinol

Platinol-AQ

Platinoxan

Platinum Ammine Chloride

Platinum Ammonium Chloride

Platinum Diamine Dichloride

Randa

trans-DDP

Trans-DDP

Trans-Diaminedichloroplatinum

trans-diamminedichloridoplatinum(II)

Trans-Diamminedichloroplatinum

Trans-Dichlorodiammine Platinum

Trans-Platinumdiammine Dichloride

Paclitaxel

Approved, Vet_approved

33069-62-4

36314

Synonyms:

(2AR-(2aalpha,4b,4abeta,6b,9a(a r*,betas*),11a,12a,12balpha))-b-(benzoylamino)-a-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4b,4abeta,6b,9a(a r*,betas*),11a,12a,12balpha))-b-(benzoylamino)-a-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4β,4abeta,6β,9α(α r*,betas*),11α,12α,12balpha))-β-(benzoylamino)-α-hydroxybenzenepropanoate 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

(2AR-(2aalpha,4β,4abeta,6β,9α(α r*,betas*),11α,12α,12balpha))-β-(benzoylamino)-α-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester

12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

157069-30-2

33069-62-4

5b,20-Epoxy-1,2-a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5b,20-Epoxy-1,2-a,4,7b,10b,13a-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5β,20-epoxy-1,2-α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

5β,20-epoxy-1,2-α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetic acid 2-benzoic acid 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine

7 Epi taxol

7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.

7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.

7-epi-Paclitaxel

7-Epipaclitaxel

7-Epi-paclitaxel

7-epi-Taxol

7-Epitaxol

7-Epi-taxol

AB00513812

ABI 007

abi-007

ABI007

ABI-007

Abraxane

Abraxane (TN)

Abraxane I.V. Suspension

Abraxis BioScience brand of albumin-bound paclitaxel

AC1L1IOG

AC1L1VJI

AC1L9AVF

AC-675

ACon1_002231

albumin-bound paclitaxel

Ambotz33069-62-4

ANX-513

Anzatax

Asotax

BIDD:PXR0046

Bio-0076

Bio1_000362

Bio1_000851

Bio1_001340

Bio2_000416

Bio2_000896

BMS 181339-01

BMS-181339

BMS-181339-01

BPBio1_000320

BRD-A23723433-001-01-2

BRD-A28746609-001-04-0

BRD-K62008436-001-03-1

Bris taxol

Bristaxol

BSPBio_000290

BSPBio_001152

BSPBio_002614

C07394

C466458

C47H51NO14

Capxol

CCRIS 8143

CHEBI:103439

CHEBI:45863

CHEMBL100910

CHEMBL418410

CHEMBL48

CID36314

CID441276

CID4666

CID6713921

CID6915727

cMAP_000068

CPD-8718

D00491

DB01229

DHP-107

DHP-208

DivK1c_000441

DRG-0190

DTS-301

Ebetaxel

EmPAC

Epitaxol

EU-0101201

Genaxol

Genetaxyl

Genexol

Genexol-PM

HMS1362J13

HMS1568O12

HMS1792J13

HMS1922K08

HMS1990J13

HMS2090D07

HMS2093K15

HMS501G03

HSDB 6839

I06-0014

IDI1_000441

IDI1_002171

Intaxel

KBio1_000441

KBio2_000492

KBio2_002016

KBio2_002509

KBio2_003060

KBio2_004584

KBio2_005077

KBio2_005628

KBio2_007152

KBio2_007645

KBio3_000903

KBio3_000904

KBio3_001834

KBio3_002987

KBioGR_000492

KBioGR_001893

KBioGR_002509

KBioSS_000492

KBioSS_002016

KBioSS_002517

LipoPac

LMPR0104390001

Lopac0_001201

LS-31070

MBT 0206

MEGxp0_001940

Micellar Paclitaxel

Mitotax

MLS000863266

MLS001077297

MLS002154218

MLS002172439

MLS002695976

MolPort-001-742-627

MolPort-003-665-783

MolPort-003-932-365

MPI-5018

nab-paclitaxel

Nanotaxel

NCGC00024995-02

NCGC00024995-03

NCGC00024995-04

NCGC00024995-05

NCGC00024995-06

NCGC00024995-07

NCGC00164367-01

NCGC00164367-02

NCGC00164367-03

nchembio.188-comp1

nchembio.2007.34-comp9

nchembio.215-comp9

nchembio853-comp6

NCI60_000601

Neuro_000060

NINDS_000441

NK 105

Nova-12005

NP-010981

NSC 125973

NSC125973

NSC-125973

NSC358882

OAS-PAC-100

OncoGel

Onxal

Onxol

Onxol, Taxol, Nov-Onxol, Paclitaxel

P1632

Paclical

Pacligel

paclitaxel

Paclitaxel

Paclitaxel (JAN/USP)

Paclitaxel (JAN/USP/INN)

Paclitaxel (Taxol)

Paclitaxel [USAN:INN:BAN]

Paclitaxel, (4 alpha)-isomer

Paxceed

Paxene

Paxoral

Plaxicel

Praxel

Prestwick0_000155

Prestwick1_000155

Prestwick2_000155

Prestwick3_000155

Probes2_000350

QW 8184

S1150_Selleck

S-8184 Paclitaxel Injectable Emulsion

SDCCGMLS-0066823.P001

SDP-013

SMP1_000228

SMR000394086

SMR000857385

SPBio_000943

SPBio_002229

Spectrum_001536

SPECTRUM1503908

Spectrum2_000872

Spectrum3_001057

Spectrum4_001197

Spectrum5_001491

ST50306996

T 7402

T1912_SIGMA

T7191_SIGMA

T7402_SIGMA

TA1

TaxAlbin

Taxol

TAXOL

TAXOL (TN)

Taxol a

Taxol A

Taxol Konzentrat

TAXOL, 10-EPI,

Taxol, bris

Taxol.RTM. (Registered Trademark)

TXL

UNII-P88XT4IS4D

UPCMLD-DP108:001

UPCMLD-DP108:002

Vascular Wrap

weekly paclitaxel

Xorane

Yewtaxan

Gemcitabine

Approved

95058-81-4

60750

Synonyms:

103882-84-4

122111-03-9

2',2'-DFDC

2',2'-DiF-dC

2',2'-difluoro-2'-Deoxycytidine

2',2'-Difluoro-2'-deoxycytidine

2',2'-Difluorodeoxycytidine

2'-Deoxy-.beta.-D-2',2'-difluorocytidine

2'-Deoxy-2',2'-difluorocytidine

2'-Deoxy-2',2''-difluorocytidine-5'-O-monophosphate

2'-Deoxy-2'-difluorocytidine

4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-amino-1-((2R,4R,5R)-3,3-difluoro-4-Hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-amino-1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

4-Amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-pyrimidin-2-one

95058-81-4

AB1004842

AC1L1TUQ

C07650

CCRIS 8984

CHEBI:175901

CHEMBL888

CID60750

Cytidine, 2'-deoxy-2',2'-difluoro-2'-Deoxy-.beta.-D-2',2'-difluorocytidine

D02368

DB00441

DDFC

DFdC

DFDC

DFdCyd

Folfugem

Gamcitabine

Gemcel

Gemcin

Gemcitabin

Gemcitabina

Gemcitabina [INN-Spanish]

gemcitabine

Gemcitabine

Gemcitabine (USAN/INN)

Gemcitabine HCl

Gemcitabine hydrochloride

Gemcitabine stereoisomer

Gemcitabine, (alpha-D-threo-pentofuranosyl)-isomer

Gemcitabine, (beta-D-threo-pentafuranosyl)-isomer

Gemcitabine, (D-threo-pentafuranosyl)-isomer

Gemcitabinum

Gemcitabinum [INN-Latin]

GemLip

Gemtro

Gemzar

Gemzar (hydrochloride)

GEO

HMS2089P10

HSDB 7567

Inno-D07001

LS-59139

LY 188011

LY188011

LY-188011

NCGC00168784-01

NChemBio.2007.10-comp25

nchembio.573-comp7

nchembio.90-comp2

NSC 613327

NSC613327

TL8005979

UNII-B76N6SBZ8R

Zefei

ZINC18279854

Oxaliplatin

Approved, Investigational

61825-94-3

43805 6857599 5310940 9887054

Synonyms:

CHEMBL1201055

CID9887054

D01790

DACPLAT

Diaminocyclohexane Oxalatoplatinum

Eloxatin

Eloxatin (TN)

Elplat

Foloxatine

L-OHP

Oxalatoplatin

Oxalatoplatinum

oxaliplatin

Oxaliplatin (JAN/USAN/INN)

Oxaliplatin [Usan:Inn:Ban]

oxaliplatine

oxaliplatino

Oxaliplatino [Spanish]

oxaliplatinum

Oxaliplatinum [Latin]

Oxaloplatine [French]

Oxaloplatino [Spanish]

Transplatin

Doxorubicin

Approved, Investigational

23214-92-8

31703

Synonyms:

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside

(1S,3S)-3-Glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-a-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

(8S-cis)-10-((3-amino-2,3,6-Trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

111266-55-8

14-hydroxydaunomycin

14-Hydroxydaunomycin

14-hydroxydaunorubicine

14-Hydroxydaunorubicine

23214-92-8

23257-17-2

24385-08-8

25311-50-6

25316-40-9

25316-40-9 (hydrochloride)

29042-30-6

AC1L1M5T

AC1Q29OJ

adiblastine (hydrochloride salt)

ADM

ADR

adr iablatina (hydrochloride salt)

Adriablastin

Adriablastine

adriablastine (hydrochloride salt)

adriablatina (hydrochloride salt)

Adriacin (hydrochloride salt)

Adriamycin

Adriamycin PFS

Adriamycin PFS (hydrochloride salt)

Adriamycin RDF

Adriamycin RDF (hydrochloride salt)

Adriamycin semiquinone

Adriamycin Semiquinone

Adriblas tina

Adriblastin

Adriblastina

Adriblastina (hydrochloride salt)

Adriblastina (TN)

Adriblastine

adriblatina (hydrochloride salt)

Adrimedac

Aerosolized Doxorubicin

Baxter brand OF doxorubicin hydrochloride

Bedford brand OF doxorubicin hydrochloride

BPBio1_000502

BRD-K92093830-003-04-3

Bristol-myers squibb brand OF doxorubicin hydrochloride

BSPBio_000456

BSPBio_001031

C01661

C27H29NO11

Caelyx

CCRIS 739

Cell pharm brand OF doxorubicin hydrochloride

CHEBI:28748

CHEMBL179

CID31703

Columbia brand OF doxorubicin hydrochloride

Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74

Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120

D03899

DB00997

DM2

Doxil

Doxo

doxo Cell

doxo-Cell

Doxolem

doxorubicin

Doxorubicin

Doxorubicin (USAN/INN)

Doxorubicin [USAN:INN:BAN]

Doxorubicin citrate

Doxorubicin HCl

Doxorubicin hexal

Doxorubicin hydrochloride

Doxorubicin Hydrochloride

Doxorubicin hydrochloride (hydrochloride salt)

Doxorubicin NC

Doxorubicina

Doxorubicina [INN-Spanish]

Doxorubicina ferrer farm

Doxorubicina funk

Doxorubicina tedec

Doxorubicine

Doxorubicine [INN-French]

Doxorubicine baxter

Doxorubicin-hLL1

Doxorubicin-hLL1 conjugate

Doxorubicin-P4/D10

Doxorubicin-P4/D10 conjugate

Doxorubicinum

Doxorubicinum [INN-Latin]

Doxotec

DOX-SL

EINECS 245-495-6

Elan brand OF doxorubicin hydrochloride

Farmablastina (hydrochloride salt)

Farmiblastina

Ferrer brand OF doxorubicin hydrochloride

FI 106

Hexal brand OF doxorubicin hydrochloride

HMS2089H06

HSDB 3070

Hydrochloride, doxorubicin

Hydroxydaunomycin hydrochlor ide (hydrochloride salt)

Hydroxydaunomycin hydrochloride (hydrochloride salt)

Hydroxydaunorubicin

Hydroxydaunorubicin hydrochloride (hydrochloride salt)

JT9100000

Kenfarma brand OF doxorubicin hydrochloride

Lemery brand OF doxorubicin hydrochloride

LMPK13050001

LS-1029

LS-165655

Medac brand OF doxorubicin hydrochloride

MLS000759533

Myocet

NChemBio.2007.10-comp13

nchembio809-comp5

NCI-C01514

NDC 38242-874

Neocorp brand OF doxorubicin hydrochloride

NIOSH/JT9100000

NSC 123127

Onkodox

Onkoworks brand OF doxorubicin hydrochloride

Pfizer brand OF doxorubicin hydrochloride

Prasfarma brand OF doxorubicin hydrochloride

Prestwick0_000438

Prestwick1_000438

Prestwick2_000438

Prestwick3_000438

Probes1_000151

Probes2_000129

RDF Rubex

Resmycin

Ribodoxo

Ribosepharm brand OF doxorubicin hydrochloride

Rubex

Rubex (hydrochloride salt)

SMP1_000106

SPBio_002395

Tedec meiji brand OF doxorubicin hydrochloride

ThermoDox

TLC D-99

Triferric doxorubicin

UNII-80168379AG

Urokit doxo cell

Urokit doxo-cell

Doxil

Approved June 1999

31703

Etanidazole

Investigational

Not Applicable

22668-01-5

Imidazole

Experimental, Investigational

Not Applicable

288-32-4

795

Synonyms:

{Pyrro[b]monazole}

1,3-Diaza-2,4-cyclopentadiene

1,3-Diazole

1H-Imidazole

Al-imidazole

Cu-imidazole

Glyoxalin

Glyoxaline

Him

IMD

Imidazol

Imidazole acetate

Imidazole citrate

Imidazole conjugate monoacid

Imidazole monohydrochloride

Imidazole monophosphonate

Imidazole sodium

Imidazolium chloride

Iminazole

Imutex

Miazole

N,N'-1,2-ethenediylmethanimidamide

N,N'-vinyleneformamidine

pyrro(b)Monazole

pyrro[b]Monazole

Immunologic Factors

Protective Agents

Adjuvants, Immunologic

Viscosupplements

Antimitotic Agents

Albumin-Bound Paclitaxel

Mitomycins

Antineoplastic Agents, Phytogenic

Pharmaceutical Solutions

Antibodies

Not Applicable

Immunoglobulins

Not Applicable

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Serum Biomarkers in Diagnosis of Mesothelioma	Completed	NCT02029105
2	International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)	Recruiting	NCT03210298
3	EF5 in Detecting Oxygen Level and Blood Vessels in Tumor Cells of Patients Undergoing Photodynamic Therapy for Intraperitoneal or Pleural Cancer	Terminated	NCT00028782	Not Applicable	etanidazole
4	Early Detection and Staging of Endobronchial Lung and Pleural Cancer, Airway Injury, and Prostate Cancer	Withdrawn	NCT00581503

Search NIH Clinical Center for Pleural Cancer

Cochrane evidence based reviews: pleural neoplasms

Sources

Genetic Tests for Pleural Cancer

Sources

Anatomical Context for Pleural Cancer

MalaCards organs/tissues related to Pleural Cancer:

⁴¹

Lung, Prostate, Heart, Ovary, Pancreas, Cervix, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Pleural Cancer:

¹⁹

The Pleura

Sources

Publications for Pleural Cancer

Articles related to Pleural Cancer:

(show all 31)

#	Title	Authors	Year
1	MR Imaging of Pleural Neoplasms. ( 29613962 )	Carter BW...Lichtenberger JP	2018
2	Application of Immunohistochemistry in the Diagnosis of Pulmonary and Pleural Neoplasms. ( 28644685 )	Woo JS...Xu H	2017
3	Survival patterns in lung and pleural cancer in Europe 1999-2007: Results from the EUROCARE-5 study. ( 26421826 )	Francisci S....Sant M.	2015
4	A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids. ( 24496222 )	Ruppen J....Guenat O.T.	2014
5	Pleural cancer mortality in Spain: time-trends and updating of predictions up to 2020. ( 24195451 )	LA^pez-Abente G....Pastor-Barriuso R.	2013
6	Pleural cancer antigen-125 levels in benign and malignant pleural effusions. ( 23575338 )	Choi W.I....Kwon K.Y.	2013
7	Industrial pollution and pleural cancer mortality in Spain. ( 22444064 )	LA^pez-Abente G....GarcA-a-PAcrez J.	2012
8	Systematic evaluation of three different commercial software solutions for automatic segmentation for adaptive therapy in head-and-neck, prostate and pleural cancer. ( 22989046 )		2012
9	Immunohistochemistry: applications to the evaluation of lung and pleural neoplasms: part 1. ( 23131940 )	Mani H...Zander DS	2012
10	Immunohistochemistry: applications to the evaluation of lung and pleural neoplasms: part 2. ( 23131941 )	Mani H...Zander DS	2012
11	Value of D2-40 in the differential diagnosis of pleural neoplasms with emphasis on its positivity in solitary fibrous tumor. ( 20436345 )	Hu Y....Xu H.	2010
12	Development of a rabbit pleural cancer model by using VX2 tumors. ( 18589872 )	Kreuter K.A....Brenner M.	2008
13	Immunohistochemistry for assessment of pulmonary and pleural neoplasms: a review and update. ( 18784820 )	Tan D...Zander DS	2008
14	Minimally invasive localization of oncolytic herpes simplex viral therapy of metastatic pleural cancer. ( 16037824 )	Stiles B.M....Fong Y.	2006
15	Municipal pleural cancer mortality in Spain. ( 15723885 )	LA^pez-Abente G....PAcrez-GA^mez B.	2005
16	Three decades of pleural cancer and mesothelioma registration in Austria where asbestos cement was invented. ( 12733090 )		2003
17	Replication-competent herpes virus NV1020 as direct treatment of pleural cancer in a rat model. ( 12091817 )	Ebright M.I....Fong Y.	2002
18	Exposure to asbestos and lung and pleural cancer mortality among pulp and paper industry workers. ( 12085486 )	Carel R....Kogevinas M.	2002
19	Is the ratio of pleural mesothelioma mortality to pleural cancer mortality approximately unity for Italy? Considerations from the oldest regional mesothelioma register in Italy. ( 12085195 )		2002
20	Prognostic implication of Ki-67 immunostaining in treating subclinical pleural cancer found at thoracotomy in lung cancer patients. ( 11426745 )	Shiba M....Fujisawa T.	2001
21	An age, period and cohort analysis of pleural cancer mortality in Europe. ( 10954257 )		2000
22	Differences in occupational mortality from pleural cancer, peritoneal cancer, and asbestosis. ( 8535500 )	Coggon D....Pannett B.	1995
23	Metastatic pleural cancer in radionuclide angiocardiography. A pulmonary time-activity curve mimicking left-to-right cardiac shunt. ( 8565354 )	Lee J....Lee K.	1995
24	Smooth muscle tumours presenting as pleural neoplasms. ( 8522286 )	Moran CA...Koss MN	1995
25	&quot;Patient-like&quot; nude mouse metastatic model of advanced human pleural cancer. ( 7806595 )	Astoul P....Hoffman R.M.	1994
26	Patient-like nude-mouse and scid-mouse models of human lung and pleural cancer (review). ( 21573423 )		1993
27	Immunohistochemical analysis of pulmonary and pleural neoplasms with monoclonal antibodies B72.3 and CSLEX-1. ( 1972825 )	Koukoulis GK...Gould VE	1990
28	Immunohistochemical analysis of pulmonary and pleural neoplasms using a monoclonal antibody (47D10) which reacts with nonspecific cross-reacting antigen. ( 2480629 )	Radosevich JA...Gould VE	1989
29	Immunohistochemical analysis of normal and mutated ras oncogene p21 expression in human pulmonary and pleural neoplasms. ( 2567085 )	Radosevich JA...Rosen ST	1989
30	Immunohistochemical evaluation of ras oncogene expression in pulmonary and pleural neoplasms. ( 2888232 )	Lee I...Rosen ST	1987
31	Pleural neoplasms. ( 13471931 )	SMART J...HINSON KF	1957

Sources

Genes for Pleural Cancer

Genes related to Pleural Cancer (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BAP1	BRCA1 Associated Protein 1	Protein Coding	16.28	DISEASES inferred ¹⁵
2	MUC16	Mucin 16, Cell Surface Associated	Protein Coding	16.24	GeneCards inferred via : Publications (show sections)
3	EFEMP1	EGF Containing Fibulin Extracellular Matrix Protein 1	Protein Coding	16.19	DISEASES inferred ¹⁵
4	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	15.84	DISEASES inferred ¹⁵
5	SPP1	Secreted Phosphoprotein 1	Protein Coding	15.74	DISEASES inferred ¹⁵
6	ASS1	Argininosuccinate Synthase 1	Protein Coding	15.51	DISEASES inferred ¹⁵
7	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	15.38	DISEASES inferred ¹⁵
8	NF2	Neurofibromin 2	Protein Coding	15.32	DISEASES inferred ¹⁵
9	KRT5	Keratin 5	Protein Coding	15.32	DISEASES inferred ¹⁵
10	TYMS	Thymidylate Synthetase	Protein Coding	15.28	DISEASES inferred ¹⁵
11	CD274	CD274 Molecule	Protein Coding	15.23	DISEASES inferred ¹⁵
12	WT1	Wilms Tumor 1	Protein Coding	15.23	DISEASES inferred ¹⁵
13	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	15.12	DISEASES inferred ¹⁵
14	MSLN	Mesothelin	Protein Coding	8.22	DISEASES inferred ¹⁵
15	CALB2	Calbindin 2	Protein Coding	6.91	DISEASES inferred ¹⁵
16	MIR611	MicroRNA 611	RNA Gene	5.35	DISEASES inferred ¹⁵
17	KAZALD1	Kazal Type Serine Peptidase Inhibitor Domain 1	Protein Coding	5.35	DISEASES inferred ¹⁵

Sources

Variations for Pleural Cancer

Sources

Expression for Pleural Cancer

Search GEO for disease gene expression data for Pleural Cancer.

Sources

Pathways for Pleural Cancer

Pathways related to Pleural Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glioblastoma Multiforme ⁶⁴	10.84	AKT1 CDKN2A NF2

Sources

GO Terms for Pleural Cancer

Biological processes related to Pleural Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell-matrix adhesion	GO:0001953	9.37	CDKN2A NF2
2	negative regulation of protein kinase activity	GO:0006469	9.33	AKT1 CDKN2A NF2
3	apoptotic mitochondrial changes	GO:0008637	9.32	AKT1 CDKN2A
4	response to growth hormone	GO:0060416	9.26	AKT1 ASS1
5	diaphragm development	GO:0060539	8.96	ASS1 WT1
6	negative regulation of leukocyte cell-cell adhesion	GO:1903038	8.62	AKT1 ASS1

Sources

Sources for Pleural Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia