MCID: PLR006
MIFTS: 41

Pleural Cancer

Categories: Cancer diseases

Aliases & Classifications for Pleural Cancer

MalaCards integrated aliases for Pleural Cancer:

Name: Pleural Cancer 12 15
Pleural Neoplasms 44 73
Malignant Tumor of Pleura 73
Neoplasm of Pleura 12
Pleural Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5158
ICD10 33 C38.4
ICD9CM 35 163 163.9
MeSH 44 D010997
NCIt 50 C3332 C3547
SNOMED-CT 68 93966009

Summaries for Pleural Cancer

Disease Ontology : 12 A connective tissue cancer that located in the pleura.

MalaCards based summary : Pleural Cancer, also known as pleural neoplasms, is related to pleural disease and malignant pleural mesothelioma. An important gene associated with Pleural Cancer is BAP1 (BRCA1 Associated Protein 1), and among its related pathways/superpathways is Glioblastoma Multiforme. The drugs Alimta and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include lung, prostate and heart, and related phenotypes are behavior/neurological and immune system

Related Diseases for Pleural Cancer

Diseases related to Pleural Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 pleural disease 31.4 BAP1 CALB2 EFEMP1 MSLN SMUG1 SPP1
2 malignant pleural mesothelioma 30.7 BAP1 CALB2 CDKN2A EFEMP1 MSLN SPP1
3 benign mesothelioma 29.7 KRT5 WT1
4 corpus luteum cyst 10.3 MUC16 SMUG1
5 heart cancer 10.3 MUC16 SMUG1
6 rhabdoid meningioma 10.2 BAP1 NF2
7 malignant acrospiroma 10.2 KRT5 SMUG1
8 malignant spiradenoma 10.2 KRT5 SMUG1
9 inverted transitional papilloma 10.2 CDKN2A KRT5
10 malignant peritoneal mesothelioma 10.2 CDKN2A NF2
11 keratinizing squamous cell carcinoma 10.2 CDKN2A KRT5
12 fallopian tube squamous cell carcinoma 10.2 CDKN2A WT1
13 cornea cancer 10.2 CDKN2A NF2
14 pharynx squamous cell carcinoma 10.2 AKT1 SMUG1
15 atypical neurofibroma 10.2 CDKN2A NF2
16 prostate squamous cell carcinoma 10.2 KRT5 SMUG1
17 melanomatosis 10.2 CDKN2A WT1
18 anus cancer 10.2 CDKN2A KRT5 SMUG1
19 oropharynx cancer 10.1 CDKN2A KRT5 SMUG1
20 pseudo-meigs syndrome 10.1 CALB2 MUC16
21 sarcomatoid mesothelioma 10.1 CDKN2A WT1
22 optic nerve sheath meningioma 10.1 CDKN2A KRT5 NF2
23 anal canal squamous cell carcinoma 10.1 CDKN2A KRT5
24 optic nerve neoplasm 10.1 CDKN2A KRT5 NF2
25 fibrosarcomatous osteosarcoma 10.1 KRT5 SPP1
26 anal squamous cell carcinoma 10.1 AKT1 CDKN2A
27 peritoneum cancer 10.1 BAP1 KRT5 WT1
28 fallopian tube endometrioid adenocarcinoma 10.1 CALB2 CDKN2A
29 lymphoepithelioma-like thymic carcinoma 10.1 CD274 CDKN2A KRT5
30 adenofibroma 10.1 CALB2 MUC16
31 pharynx cancer 10.1 AKT1 CDKN2A SMUG1
32 papilloma 10.1 CDKN2A KRT5 TYMS
33 nasopharyngeal disease 10.1 AKT1 CDKN2A SMUG1
34 cervix disease 10.1 AKT1 CDKN2A SMUG1
35 lymphohistiocytoid mesothelioma 10.1 CALB2 CDKN2A
36 uterine anomalies 10.1 AKT1 CDKN2A SMUG1
37 breast giant fibroadenoma 10.1 CDKN2A WT1
38 female reproductive system disease 10.1 AKT1 CDKN2A SMUG1
39 reproductive system disease 10.1 AKT1 CDKN2A SMUG1
40 fallopian tube carcinosarcoma 10.1 CALB2 WT1
41 endocrine gland cancer 10.1 AKT1 CDKN2A SMUG1
42 central nervous system cancer 10.1 AKT1 CDKN2A NF2
43 nervous system cancer 10.1 AKT1 CDKN2A NF2
44 gastrointestinal system disease 10.1 AKT1 CDKN2A SMUG1
45 intestinal disease 10.1 AKT1 SMUG1 TYMS
46 respiratory system disease 10.0 AKT1 CD274 SMUG1
47 peritoneal benign neoplasm 10.0 CALB2 WT1
48 diffuse peritoneal leiomyomatosis 10.0 CALB2 WT1
49 peritoneal mesothelioma 10.0 BAP1 CDKN2A NF2 WT1
50 venous hemangioma 10.0 CALB2 WT1

Comorbidity relations with Pleural Cancer via Phenotypic Disease Network (PDN):


Deficiency Anemia

Graphical network of the top 20 diseases related to Pleural Cancer:



Diseases related to Pleural Cancer

Symptoms & Phenotypes for Pleural Cancer

MGI Mouse Phenotypes related to Pleural Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 AKT1 ASS1 CALB2 CD274 CDKN2A EFEMP1
2 immune system MP:0005387 9.97 AKT1 ASS1 BAP1 CD274 CDKN2A EFEMP1
3 integument MP:0010771 9.91 AKT1 ASS1 BAP1 CD274 CDKN2A EFEMP1
4 mortality/aging MP:0010768 9.7 AKT1 ASS1 BAP1 CD274 CDKN2A EFEMP1
5 liver/biliary system MP:0005370 9.63 AKT1 CDKN2A EFEMP1 NF2 SPP1 WT1
6 neoplasm MP:0002006 9.17 AKT1 BAP1 CDKN2A NF2 SMUG1 SPP1

Drugs & Therapeutics for Pleural Cancer

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Alimta 18 49 PEMETREXED (also Pemetrexed Disodium) Eli Lilly February 2004

Drugs for Pleural Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
2
Cisplatin Approved 15663-27-1 2767 441203 84093
3
Paclitaxel Approved, Vet_approved 33069-62-4 36314
4
Gemcitabine Approved 95058-81-4 60750
5
Oxaliplatin Approved, Investigational 61825-94-3 43805 6857599 5310940 9887054
6
Doxorubicin Approved, Investigational 23214-92-8 31703
7
Doxil Approved June 1999 31703
8
Etanidazole Investigational Not Applicable 22668-01-5
9
Imidazole Experimental, Investigational Not Applicable 288-32-4 795
10 Immunologic Factors
11 Protective Agents
12 Adjuvants, Immunologic
13 Viscosupplements
14 Antimitotic Agents
15 Albumin-Bound Paclitaxel
16 Mitomycins
17 Antineoplastic Agents, Phytogenic
18 Pharmaceutical Solutions
19 Antibodies Not Applicable
20 Immunoglobulins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Serum Biomarkers in Diagnosis of Mesothelioma Completed NCT02029105
2 International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) Recruiting NCT03210298
3 EF5 in Detecting Oxygen Level and Blood Vessels in Tumor Cells of Patients Undergoing Photodynamic Therapy for Intraperitoneal or Pleural Cancer Terminated NCT00028782 Not Applicable etanidazole
4 Early Detection and Staging of Endobronchial Lung and Pleural Cancer, Airway Injury, and Prostate Cancer Withdrawn NCT00581503

Search NIH Clinical Center for Pleural Cancer

Cochrane evidence based reviews: pleural neoplasms

Genetic Tests for Pleural Cancer

Anatomical Context for Pleural Cancer

MalaCards organs/tissues related to Pleural Cancer:

41
Lung, Prostate, Heart, Ovary, Pancreas, Cervix, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Pleural Cancer:

19
The Pleura

Publications for Pleural Cancer

Articles related to Pleural Cancer:

(show all 31)
# Title Authors Year
1
MR Imaging of Pleural Neoplasms. ( 29613962 )
2018
2
Application of Immunohistochemistry in the Diagnosis of Pulmonary and Pleural Neoplasms. ( 28644685 )
2017
3
Survival patterns in lung and pleural cancer in Europe 1999-2007: Results from the EUROCARE-5 study. ( 26421826 )
2015
4
A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids. ( 24496222 )
2014
5
Pleural cancer mortality in Spain: time-trends and updating of predictions up to 2020. ( 24195451 )
2013
6
Pleural cancer antigen-125 levels in benign and malignant pleural effusions. ( 23575338 )
2013
7
Industrial pollution and pleural cancer mortality in Spain. ( 22444064 )
2012
8
Systematic evaluation of three different commercial software solutions for automatic segmentation for adaptive therapy in head-and-neck, prostate and pleural cancer. ( 22989046 )
2012
9
Immunohistochemistry: applications to the evaluation of lung and pleural neoplasms: part 1. ( 23131940 )
2012
10
Immunohistochemistry: applications to the evaluation of lung and pleural neoplasms: part 2. ( 23131941 )
2012
11
Value of D2-40 in the differential diagnosis of pleural neoplasms with emphasis on its positivity in solitary fibrous tumor. ( 20436345 )
2010
12
Development of a rabbit pleural cancer model by using VX2 tumors. ( 18589872 )
2008
13
Immunohistochemistry for assessment of pulmonary and pleural neoplasms: a review and update. ( 18784820 )
2008
14
Minimally invasive localization of oncolytic herpes simplex viral therapy of metastatic pleural cancer. ( 16037824 )
2006
15
Municipal pleural cancer mortality in Spain. ( 15723885 )
2005
16
Three decades of pleural cancer and mesothelioma registration in Austria where asbestos cement was invented. ( 12733090 )
2003
17
Replication-competent herpes virus NV1020 as direct treatment of pleural cancer in a rat model. ( 12091817 )
2002
18
Exposure to asbestos and lung and pleural cancer mortality among pulp and paper industry workers. ( 12085486 )
2002
19
Is the ratio of pleural mesothelioma mortality to pleural cancer mortality approximately unity for Italy? Considerations from the oldest regional mesothelioma register in Italy. ( 12085195 )
2002
20
Prognostic implication of Ki-67 immunostaining in treating subclinical pleural cancer found at thoracotomy in lung cancer patients. ( 11426745 )
2001
21
An age, period and cohort analysis of pleural cancer mortality in Europe. ( 10954257 )
2000
22
Differences in occupational mortality from pleural cancer, peritoneal cancer, and asbestosis. ( 8535500 )
1995
23
Metastatic pleural cancer in radionuclide angiocardiography. A pulmonary time-activity curve mimicking left-to-right cardiac shunt. ( 8565354 )
1995
24
Smooth muscle tumours presenting as pleural neoplasms. ( 8522286 )
1995
25
"Patient-like" nude mouse metastatic model of advanced human pleural cancer. ( 7806595 )
1994
26
Patient-like nude-mouse and scid-mouse models of human lung and pleural cancer (review). ( 21573423 )
1993
27
Immunohistochemical analysis of pulmonary and pleural neoplasms with monoclonal antibodies B72.3 and CSLEX-1. ( 1972825 )
1990
28
Immunohistochemical analysis of pulmonary and pleural neoplasms using a monoclonal antibody (47D10) which reacts with nonspecific cross-reacting antigen. ( 2480629 )
1989
29
Immunohistochemical analysis of normal and mutated ras oncogene p21 expression in human pulmonary and pleural neoplasms. ( 2567085 )
1989
30
Immunohistochemical evaluation of ras oncogene expression in pulmonary and pleural neoplasms. ( 2888232 )
1987
31
Pleural neoplasms. ( 13471931 )
1957

Variations for Pleural Cancer

Expression for Pleural Cancer

Search GEO for disease gene expression data for Pleural Cancer.

Pathways for Pleural Cancer

Pathways related to Pleural Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 AKT1 CDKN2A NF2

GO Terms for Pleural Cancer

Biological processes related to Pleural Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell-matrix adhesion GO:0001953 9.37 CDKN2A NF2
2 negative regulation of protein kinase activity GO:0006469 9.33 AKT1 CDKN2A NF2
3 apoptotic mitochondrial changes GO:0008637 9.32 AKT1 CDKN2A
4 response to growth hormone GO:0060416 9.26 AKT1 ASS1
5 diaphragm development GO:0060539 8.96 ASS1 WT1
6 negative regulation of leukocyte cell-cell adhesion GO:1903038 8.62 AKT1 ASS1

Sources for Pleural Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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