MCID: PLR006
MIFTS: 41

Pleural Cancer

Categories: Cancer diseases

Aliases & Classifications for Pleural Cancer

MalaCards integrated aliases for Pleural Cancer:

Name: Pleural Cancer 12 15
Pleural Neoplasms 44 73
Malignant Tumor of Pleura 73
Neoplasm of Pleura 12
Pleural Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5158
ICD10 33 C38.4
ICD9CM 35 163 163.9
MeSH 44 D010997
NCIt 50 C3332 C3547

Summaries for Pleural Cancer

Disease Ontology : 12 A connective tissue cancer that located in the pleura.

MalaCards based summary : Pleural Cancer, also known as pleural neoplasms, is related to malignant pleural mesothelioma and pleural disease. An important gene associated with Pleural Cancer is BAP1 (BRCA1 Associated Protein 1). The drugs Alimta and Zoledronic acid have been mentioned in the context of this disorder. Affiliated tissues include the pleura, lung and testes, and related phenotypes are behavior/neurological and mortality/aging

Related Diseases for Pleural Cancer

Diseases related to Pleural Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 malignant pleural mesothelioma 29.2 BAP1 CALB2 EFEMP1 MSLN SPP1 TYMS
2 pleural disease 11.1
3 corpus luteum cyst 10.9 MUC16 SMUG1
4 heart cancer 10.8 MUC16 SMUG1
5 malignant spiradenoma 10.7 KRT5 SMUG1
6 scrotal carcinoma 10.7 CDKN2A SMUG1
7 inverted transitional papilloma 10.7 CDKN2A KRT5
8 keratinizing squamous cell carcinoma 10.7 CDKN2A KRT5
9 atypical neurofibroma 10.6 CDKN2A NF2
10 fallopian tube squamous cell carcinoma 10.6 CDKN2A WT1
11 anal canal squamous cell carcinoma 10.6 CDKN2A KRT5
12 schneiderian carcinoma 10.6 CDKN2A KRT5
13 pseudo-meigs syndrome 10.6 CALB2 MUC16
14 melanomatosis 10.5 CDKN2A WT1
15 oropharynx cancer 10.5 CDKN2A SMUG1
16 malignant peritoneal mesothelioma 10.5 BAP1 CDKN2A NF2
17 sarcomatoid mesothelioma 10.5 CDKN2A WT1
18 adenofibroma 10.5 CALB2 MUC16
19 cervical clear cell adenocarcinoma 10.5 CDKN2A KRT5
20 fallopian tube endometrioid adenocarcinoma 10.5 CALB2 CDKN2A
21 heart sarcoma 10.5 SMUG1 WT1
22 prostate squamous cell carcinoma 10.4 KRT5 SMUG1
23 anus cancer 10.4 CDKN2A KRT5 SMUG1
24 breast giant fibroadenoma 10.4 CDKN2A WT1
25 lymphohistiocytoid mesothelioma 10.4 CALB2 CDKN2A
26 mucinous bronchioloalveolar adenocarcinoma 10.4 CALB2 CDKN2A
27 tuberculous peritonitis 10.4 MUC16 SMUG1
28 optic nerve sheath meningioma 10.4 CDKN2A KRT5 NF2
29 gastrointestinal system cancer 10.4 CDKN2A SMUG1 TYMS
30 optic nerve neoplasm 10.4 CDKN2A KRT5 NF2
31 respiratory system cancer 10.4 CD274 CDKN2A SMUG1
32 lymphoepithelioma-like carcinoma 10.4 CD274 KRT5
33 fallopian tube carcinosarcoma 10.3 CALB2 WT1
34 peritoneum cancer 10.3 BAP1 KRT5 WT1
35 nasal cavity squamous cell carcinoma 10.3 CDKN2A KRT5
36 pancreas adenocarcinoma 10.3 CDKN2A MSLN MUC16
37 venous hemangioma 10.2 CALB2 WT1
38 papilloma 10.2 CDKN2A KRT5 TYMS
39 spindle cell liposarcoma 10.2 CALB2 WT1
40 sertoli-leydig cell tumor 10.2 CALB2 WT1
41 thymus cancer 10.1 CALB2 KRT5 SMUG1
42 sertoli cell tumor 10.1 CALB2 WT1
43 adenomatoid tumor 10.1 CALB2 MUC16 WT1
44 ovarian brenner tumor 10.1 CALB2 MUC16 WT1
45 female reproductive organ cancer 10.1 CDKN2A MSLN MUC16 SMUG1
46 peritoneal mesothelioma 10.0 BAP1 CDKN2A NF2 WT1
47 cell type cancer 10.0 CD274 CDKN2A KRT5 SMUG1
48 pericardium cancer 10.0 CALB2 MSLN SMUG1
49 pneumatosis cystoides intestinalis 10.0 CALB2 WT1
50 necrotizing sialometaplasia 9.9 CDKN2A KRT5

Comorbidity relations with Pleural Cancer via Phenotypic Disease Network (PDN):


Deficiency Anemia

Graphical network of the top 20 diseases related to Pleural Cancer:



Diseases related to Pleural Cancer

Symptoms & Phenotypes for Pleural Cancer

MGI Mouse Phenotypes related to Pleural Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 NF2 NGB SPP1 ASS1 CALB2 CD274
2 mortality/aging MP:0010768 9.9 ASS1 BAP1 CD274 CDKN2A EFEMP1 KRT5
3 integument MP:0010771 9.86 CDKN2A EFEMP1 KRT5 NF2 SPP1 ASS1
4 neoplasm MP:0002006 9.43 BAP1 CDKN2A NF2 SMUG1 SPP1 WT1
5 no phenotypic analysis MP:0003012 9.1 BAP1 CD274 CDKN2A KRT5 NGB WT1

Drugs & Therapeutics for Pleural Cancer

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Alimta 18 49 PEMETREXED (also Pemetrexed Disodium) Eli Lilly February 2004

Drugs for Pleural Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 141)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zoledronic acid Approved Phase 4,Phase 2 118072-93-8 68740
2
Iodine Approved, Investigational Phase 4,Phase 3,Not Applicable 7553-56-2 807
3
Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
4
Povidone Approved Phase 4,Phase 3 9003-39-8
5 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2
8 Micronutrients Phase 4,Phase 1
9 Trace Elements Phase 4,Phase 1
10 Diphosphonates Phase 4,Phase 2
11 Bone Density Conservation Agents Phase 4,Phase 2
12 cadexomer iodine Phase 4,Phase 3,Not Applicable
13 Plasma Substitutes Phase 4,Phase 3
14 Blood Substitutes Phase 4,Phase 3
15
Cisplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 84093 441203 2767
16
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1 216974-75-3
17
Doxycycline Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 564-25-0 54671203
18
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
19 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1
20 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1
21 Viscum album peptide Phase 3
22 Anti-Bacterial Agents Phase 3,Phase 2,Not Applicable
23 Antibiotics, Antitubercular Phase 3
24 Anti-HIV Agents Phase 3
25 Antiparasitic Agents Phase 3,Phase 2,Not Applicable
26 Antiprotozoal Agents Phase 3,Phase 2,Not Applicable
27 Anti-Retroviral Agents Phase 3
28 Antimalarials Phase 3,Phase 2,Not Applicable
29 Antiviral Agents Phase 3,Phase 2,Phase 1
30 European Mistletoe Nutraceutical Phase 3
31 silver nitrate Approved, Investigational Phase 2
32
Morphine Approved, Investigational Phase 2,Not Applicable 57-27-2 5288826
33
Ibuprofen Approved Phase 2,Not Applicable 15687-27-1 3672
34
Gemcitabine Approved Phase 2,Phase 1 95058-81-4 60750
35
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
36
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
37
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
38
Bortezomib Approved, Investigational Phase 2,Phase 1 179324-69-7 387447 93860
39
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
40
Docetaxel Approved, Investigational Phase 2,Phase 1 114977-28-5 148124
41
Vinorelbine Approved, Investigational Phase 2 71486-22-1 60780 44424639
42
Pemetrexed Approved, Investigational Phase 2 150399-23-8, 137281-23-3 446556 60843
43
Metformin Approved Phase 2 657-24-9 14219 4091
44
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
45
Naproxen Approved, Vet_approved Phase 2 22204-53-1 1302 156391
46
Pantoprazole Approved Phase 2 102625-70-7 4679
47
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
48
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1 59-30-3 6037
49
Cediranib Investigational Phase 2 288383-20-0 9933475
50
Saracatinib Investigational Phase 2 379231-04-6

Interventional clinical trials:

(show top 50) (show all 99)
# Name Status NCT ID Phase Drugs
1 Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion Completed NCT01670786 Phase 4
2 Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter Completed NCT00978939 Phase 4
3 Talc Pleurodesis in Patients With Recurrent Malignant Pleural Effusion Completed NCT00789087 Phase 4
4 Non-small Cell Lung Cancer Registry Completed NCT00099541 Phase 4 zoledronic acid
5 Betadine Pleurodesis Via Tunneled Pleural Catheters Not yet recruiting NCT02975921 Phase 4 Povidone-Iodine
6 Safety, Efficacy, and Side Effects Study of Interventional Cryotherapy in the Pleural Space("ICE PLS") Terminated NCT00747916 Phase 4
7 Indwelling Pleural Catheter for Trapped Lung Completed NCT03550027 Phase 3
8 Efficacy and Safety Study of Abnoba Viscum F 20mg in Malignant Pleural Effusion Patients Completed NCT02191540 Phase 3 Abnoba Viscum F 20mg
9 A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions Completed NCT00758316 Phase 3
10 Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small Cell Lung Cancer Completed NCT01661790 Phase 3 Bevacizumab;Cisplatin
11 Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions Completed NCT00002872 Phase 3 doxycycline
12 Talc in Treating Patients With Malignant Pleural Effusion Completed NCT00002622 Phase 3 talc;Talc
13 Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer Completed NCT00042770 Phase 3
14 Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion Recruiting NCT02674243 Phase 3 Iodopovidone solution;Talc
15 A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion Recruiting NCT02583282 Phase 3
16 Recombinant Adenoviral Human p53 Gene in Treatment of Malignant Pleural Effusion Unknown status NCT02429726 Phase 2 rAdp53;Cisplatin;rAdp53 plus cisplatin
17 Efficacy and Safety of Bevacizumab Versus Pulvis Talci in Malignant Pleural Effusion Unknown status NCT02054078 Phase 2 Bevacizumab;Pulvis talci
18 Safety and Effectiveness Study for Pleurodesis With Silver Nitrate in Malignant Pleural Effusion Unknown status NCT01125124 Phase 2 Silver Nitrate
19 Safety and Effectiveness Study of Tumor Cell-derived Microparticles to Treat Malignant Ascites and Pleural Effusion Unknown status NCT01854866 Phase 2
20 Ibuprofen or Morphine in Treating Pain in Patients Undergoing Pleurodesis for Malignant Pleural Effusion Unknown status NCT00644319 Phase 2 ibuprofen;morphine sulfate
21 Phase II Trial of Neo-Adjuvant Pemetrexed Plus Cisplatin Followed by Surgery and Radiation for Pleural Mesothelioma Completed NCT00087698 Phase 2 pemetrexed;cisplatin
22 S0509 - AZD2171 in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed By Surgery Completed NCT00243074 Phase 2 cediranib maleate
23 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
24 Tunneled Pleural Catheter in Partially Entrapped Lung Completed NCT00637676 Phase 2
25 Endostar and/or Cisplatin for Treatment of Malignant Pleural Effusion or Ascites Completed NCT01327235 Phase 2 Endostar;Cisplatin
26 FDG-Labeled PET Scan in Planning Chemotherapy in Treating Patients With Stage IIIB or IV Non-Small Cell Lung Cancer Completed NCT00564733 Phase 2 carboplatin;docetaxel;gemcitabine hydrochloride;paclitaxel
27 AZD0530 in Treating Patients With Extensive Stage Small Cell Lung Cancer Completed NCT00528645 Phase 2 saracatinib
28 Imatinib Mesylate and Paclitaxel in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer Completed NCT00408460 Phase 2 imatinib mesylate;paclitaxel
29 Phase II Study of Docetaxel + ZD1839 in Elderly Patients With Non-Small Cell Lung Cancer Completed NCT00231465 Phase 2 docetaxel (Taxotere®);ZD1839
30 The 'MADe IT' Clinical Trial: Molecular Analyses Directed Individualized Therapy for Advanced Non-Small Cell Lung Cancer Completed NCT00215930 Phase 2 Vinorelbine;Docetaxel;Gemcitabine;Carboplatin
31 Docetaxel With Either Cetuximab or Bortezomib as First-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Completed NCT00118183 Phase 2 docetaxel;bortezomib
32 Intrapleural Docetaxel Administration Using Medical Pleuroscopy in Malignant Effusion With Lung Cancer Recruiting NCT03394105 Phase 2 intrapleural docetaxel administration
33 Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleural Effusion Recruiting NCT02657460 Phase 2 cisplatin
34 Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population Recruiting NCT01411202 Phase 2 Doxycycline
35 Bevacizumab in the Treatment of Malignant Pleural Effusions of Non-squamous Non-small Cell Lung Cancer Recruiting NCT02942043 Phase 2 Bevacizumab
36 Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Recruiting NCT02122185 Phase 2 metformin hydrochloride;placebo;Chemotherapy
37 Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non-small Cell Lung Cancer Active, not recruiting NCT00126581 Phase 2 Carboplatin;Erlotinib Hydrochloride;Paclitaxel
38 Intrapleural Bevacizumab Injection for Malignant Effusion in Lung Cancer Enrolling by invitation NCT02054052 Phase 2 Bevacizumab
39 The Effect of Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection Terminated NCT01612975 Phase 2 Naproxen;Placebo
40 Cediranib as Palliative Treatment in Patients With Symptomatic Malignant Ascites or Pleural Effusion Terminated NCT01262612 Phase 2 immediate cediranib;Start cediranib after 28 days Best Supportive Care
41 Zometa Adjuvant Treatment of Malignant Pleural Effusion Due To Non-Small Cell Lung Cancer Terminated NCT01004510 Phase 2 zoledronic acid
42 Malignant Pleural Effusion With ZD6474 Terminated NCT00402896 Phase 2 ZD6474
43 Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions Unknown status NCT00066404 Phase 1
44 BAY 43-9006 in Previously Untreated Patients With Non-Small Cell Lung Cancer (NSCLC) Completed NCT00533585 Phase 1 BAY 43-9006;Paclitaxel;Carboplatin;Bevacizumab
45 Surgery and Intrapleural Docetaxel in Treating Patients With Malignant Pleural Effusion Completed NCT00114205 Phase 1 docetaxel
46 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
47 Bortezomib Plus Gemcitabine and Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer Completed NCT00052338 Phase 1 gemcitabine hydrochloride;carboplatin;bortezomib
48 Photo-induction as a Means to Improve Cisplatin Delivery to Pleural Malignancies Recruiting NCT02702700 Phase 1 Cisplatin, liposomal;Verteporfin
49 Combination Tissue Plasminogen Activator (Tpa) and Dornase Alfa (Dnase) Administration Through Intrapleural Catheters for the Treatment of Loculated or Non-Draining Malignant Pleural Effusions Recruiting NCT02135588 Phase 1 Combination TISSUE PLASMINOGEN ACTIVATOR (TPA) AND DORNASE ALFA (DNASE)
50 Phase I Trial of Afatinib (BIBW 2992) and Dasatinib in Non-small Cell Lung Cancer (NSCLC) Active, not recruiting NCT01999985 Phase 1 Dasatinib - 1A;Afatinib - 1A;Dasatinib - 1B;Afatinib - 1B

Search NIH Clinical Center for Pleural Cancer

Cochrane evidence based reviews: pleural neoplasms

Genetic Tests for Pleural Cancer

Anatomical Context for Pleural Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Pleural Cancer:

19
The Pleura

MalaCards organs/tissues related to Pleural Cancer:

41
Lung, Testes, Prostate, Endothelial, Bone, Liver

Publications for Pleural Cancer

Articles related to Pleural Cancer:

(show all 20)
# Title Authors Year
1
Survival patterns in lung and pleural cancer in Europe 1999-2007: Results from the EUROCARE-5 study. ( 26421826 )
2015
2
A microfluidic platform for chemoresistive testing of multicellular pleural cancer spheroids. ( 24496222 )
2014
3
Pleural cancer mortality in Spain: time-trends and updating of predictions up to 2020. ( 24195451 )
2013
4
Pleural cancer antigen-125 levels in benign and malignant pleural effusions. ( 23575338 )
2013
5
Industrial pollution and pleural cancer mortality in Spain. ( 22444064 )
2012
6
Systematic evaluation of three different commercial software solutions for automatic segmentation for adaptive therapy in head-and-neck, prostate and pleural cancer. ( 22989046 )
2012
7
Value of D2-40 in the differential diagnosis of pleural neoplasms with emphasis on its positivity in solitary fibrous tumor. ( 20436345 )
2010
8
Development of a rabbit pleural cancer model by using VX2 tumors. ( 18589872 )
2008
9
Minimally invasive localization of oncolytic herpes simplex viral therapy of metastatic pleural cancer. ( 16037824 )
2006
10
Municipal pleural cancer mortality in Spain. ( 15723885 )
2005
11
Three decades of pleural cancer and mesothelioma registration in Austria where asbestos cement was invented. ( 12733090 )
2003
12
Replication-competent herpes virus NV1020 as direct treatment of pleural cancer in a rat model. ( 12091817 )
2002
13
Exposure to asbestos and lung and pleural cancer mortality among pulp and paper industry workers. ( 12085486 )
2002
14
Is the ratio of pleural mesothelioma mortality to pleural cancer mortality approximately unity for Italy? Considerations from the oldest regional mesothelioma register in Italy. ( 12085195 )
2002
15
Prognostic implication of Ki-67 immunostaining in treating subclinical pleural cancer found at thoracotomy in lung cancer patients. ( 11426745 )
2001
16
An age, period and cohort analysis of pleural cancer mortality in Europe. ( 10954257 )
2000
17
Differences in occupational mortality from pleural cancer, peritoneal cancer, and asbestosis. ( 8535500 )
1995
18
Metastatic pleural cancer in radionuclide angiocardiography. A pulmonary time-activity curve mimicking left-to-right cardiac shunt. ( 8565354 )
1995
19
"Patient-like" nude mouse metastatic model of advanced human pleural cancer. ( 7806595 )
1994
20
Patient-like nude-mouse and scid-mouse models of human lung and pleural cancer (review). ( 21573423 )
1993

Variations for Pleural Cancer

Expression for Pleural Cancer

Search GEO for disease gene expression data for Pleural Cancer.

Pathways for Pleural Cancer

GO Terms for Pleural Cancer

Biological processes related to Pleural Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.46 BAP1 CDKN2A NF2 WT1
2 negative regulation of cell-matrix adhesion GO:0001953 8.96 CDKN2A NF2
3 diaphragm development GO:0060539 8.62 ASS1 WT1

Sources for Pleural Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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