Pleural Disease

Categories: Cancer diseases, Respiratory diseases
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Aliases & Classifications for Pleural Disease

MalaCards integrated aliases for Pleural Disease:

Name: Pleural Disease 11 14 75
Pleural Diseases 53 43 71
Non-Neoplastic Pleural Disorder 71
Non-Neoplastic Pleural Disease 11
Disorder of Pleura 11
Pleural Disorders 41


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Disease Ontology 11 DOID:1532
MeSH 43 D010995
NCIt 49 C26859
SNOMED-CT 68 88075009
ICD10 31 Q34.0
UMLS 71 C0032226 C1335034

Summaries for Pleural Disease

MedlinePlus: 41 Your pleura is a large, thin sheet of tissue that wraps around the outside of your lungs and lines the inside of your chest cavity. Between the layers of the pleura is a very thin space. Normally it's filled with a small amount of fluid. The fluid helps the two layers of the pleura glide smoothly past each other as your lungs breathe air in and out. Disorders of the pleura include: Pleurisy - inflammation of the pleura that causes sharp pain with breathing Pleural effusion - excess fluid in the pleural space Pneumothorax - buildup of air or gas in the pleural space Hemothorax - buildup of blood in the pleural space Many different conditions can cause pleural problems. Viral infection is the most common cause of pleurisy. The most common cause of pleural effusion is congestive heart failure. Lung diseases, like COPD, tuberculosis, and acute lung injury, cause pneumothorax. Injury to the chest is the most common cause of hemothorax. Treatment focuses on removing fluid, air, or blood from the pleural space, relieving symptoms, and treating the underlying condition. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary: Pleural Disease, also known as pleural diseases, is related to pneumothorax and mesothelioma, malignant, and has symptoms including dyspnea, apnea and snoring. An important gene associated with Pleural Disease is ADA (Adenosine Deaminase), and among its related pathways/superpathways are miRNAs involved in DNA damage response and OSX and miRNAs in tooth development. The drugs Plasminogen and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and t cells.

Disease Ontology: 11 A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism.

Wikipedia: 75 Pleural disease occurs in the pleural space, which is the thin fluid-filled area in between the two... more...

Related Diseases for Pleural Disease

Diseases related to Pleural Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 352)
# Related Disease Score Top Affiliating Genes
1 pneumothorax 32.1 FLCN CRP CALB2
2 mesothelioma, malignant 30.9 MSLN MIR625 MIR32 MIR30E MIR29C MIR17
3 lung disease 30.6 MIR21 MIR17 MIR142 H2AC18
4 pulmonary disease, chronic obstructive 30.5 MIR223 MIR21 MIR17 MIR142 H2AC18 CRP
5 respiratory failure 30.5 MIR21 MIR17 MIR142 H2AC18 CRP
6 interstitial lung disease 30.2 MIR223 MIR21 MIR142 H2AC18 CRP
7 peritoneal mesothelioma 30.2 MSLN MIR625 CALB2
8 constrictive pericarditis 30.2 CRP CALB2 ADA
9 thyroid gland follicular carcinoma 30.1 MIR17 MIR138-1 MIR125A
10 mycobacterium tuberculosis 1 30.0 MIR223 MIR21 H2AC18 CRP ADA
11 diffuse large b-cell lymphoma 30.0 MIR21 MIR17 MIR142 MIR125A H2AC18
12 lung cancer susceptibility 3 30.0 MSLN MIR30E MIR21 MIR193A MIR17 MIR142
13 endometriosis 29.9 MIR29C MIR223 MIR17 MIR142 MIR125A CALB2
14 lung cancer 29.9 MSLN MIRLET7A1 MIR625 MIR32 MIR30E MIR29C
15 pleural cancer 29.7 MSLN MIR625 MIR32 MIR30E MIR29C MIR29B1
16 leukemia, chronic lymphocytic 29.7 MIR30E MIR29C MIR29B1 MIR223 MIR21 MIR193A
17 immune deficiency disease 29.7 MIR29B1 MIR223 MIR21 MIR17 MIR142 MIR125B1
18 ovarian cancer 29.5 MSLN MIRLET7A1 MIR30E MIR29C MIR223 MIR21
19 pleurisy 11.0
20 chylothorax, congenital 10.9
21 benign mesothelioma 10.5
22 malignant epithelial mesothelioma 10.4 MSLN CALB2
23 pulmonary blastoma 10.4 MIRLET7A1 MIR125B1 MIR125A
24 splenic tuberculosis 10.4 MSLN CRP ADA
25 liver fibroma 10.4 MSLN CALB2
26 malignant biphasic mesothelioma 10.4 MSLN CALB2
27 urogenital tuberculosis 10.4 CRP ADA
28 pericardial tuberculosis 10.4 CRP CALB2 ADA
29 tuberculous peritonitis 10.4 CRP CALB2 ADA
30 pleural lipoma 10.4 CRP CALB2 ADA
31 melanoma in congenital melanocytic nevus 10.4 MIR29C MIR21 H2AC18
32 leiomyoma, uterine 10.4 MIR32 MIR29C MIR21
33 ischemic bone disease 10.4 MIR21 MIR17 MIR125A
34 limb ischemia 10.4 MIR21 MIR17 CRP
35 peripheral artery disease 10.4 MIR21 MIR17 CRP
36 ovarian serous carcinoma 10.4 MIR21 MIR125A H2AC18
37 hematocele of tunica vaginalis testis 10.4 CRP CALB2
38 lymph node tuberculosis 10.4 CRP ADA
39 degenerative disc disease 10.4 MIR223 MIR17 MIR125B1
40 pneumothorax, primary spontaneous 10.4
41 pericardial mesothelioma 10.4 MSLN CALB2
42 mature t-cell and nk-cell lymphoma 10.4 MIR21 MIR17 H2AC18
43 infected hydrocele 10.4 CRP CALB2
44 pericardium cancer 10.4 MSLN CALB2
45 peritoneum cancer 10.4 MSLN H2AC18 CALB2
46 esophageal tuberculosis 10.4 CRP ADA
47 cerebral arterial disease 10.4 MIR125B1 MIR125A CRP
48 ovary adenocarcinoma 10.4 MIR29C MIR17 H2AC18
49 intestinal tuberculosis 10.4 CRP ADA
50 bone deterioration disease 10.4 MIR223 MIR21 MIR17 MIR125B1

Graphical network of the top 20 diseases related to Pleural Disease:

Diseases related to Pleural Disease

Symptoms & Phenotypes for Pleural Disease

UMLS symptoms related to Pleural Disease:

dyspnea; apnea; snoring; coughing; pleuritic pain

Drugs & Therapeutics for Pleural Disease

Drugs for Pleural Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Plasminogen Approved Phase 4 9001-91-6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
Cisatracurium Approved, Investigational Phase 4 96946-41-7 62887
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456 5824
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
Ranitidine Approved, Withdrawn Phase 4 66357-59-3, 82530-72-1, 66357-35-5 3001055 5039
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
Atropine Approved, Vet_approved Phase 4 101-31-5, 5908-99-6, 51-55-8 3661 154417 174174
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
15 Tissue Plasminogen Activator Phase 4
16 Fibrinolytic Agents Phase 4
17 Anesthetics Phase 4
18 Tea Phase 4
Ranitidine bismuth citrate Phase 4
Nitrous oxide Approved, Vet_approved Phase 2, Phase 3 10024-97-2 948
Acetaminophen Approved Phase 1, Phase 2 103-90-2 1983
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4 254741536
Diphenhydramine Approved, Investigational Phase 1, Phase 2 147-24-0, 58-73-1 3100
Promethazine Approved, Investigational Phase 1, Phase 2 60-87-7 4927
26 Alkylating Agents Phase 1, Phase 2
27 Antirheumatic Agents Phase 1, Phase 2
28 Antineoplastic Agents, Alkylating Phase 1, Phase 2
29 Antiemetics Phase 1, Phase 2
30 Antineoplastic Agents, Immunological Phase 1, Phase 2
31 Immunosuppressive Agents Phase 1, Phase 2
32 Immunologic Factors Phase 1, Phase 2
Trioxsalen Approved Phase 1 3902-71-4 5585
Dihematoporphyrin ether Investigational Phase 1 97067-70-4
Diethyl ether Experimental Phase 1 60-29-7 3283
36 Photosensitizing Agents Phase 1
37 Hematoporphyrin Derivative Phase 1
38 Dermatologic Agents Phase 1
Cisplatin Approved 15663-27-1 2767 5702198 441203
Paclitaxel Approved, Vet_approved 33069-62-4 36314
Gemcitabine Approved 95058-81-4, 122111-03-9 60750
Doxorubicin Approved, Investigational 23214-92-8 31703
Oxaliplatin Approved, Investigational 61825-94-3 43805 11947679 6857599
Mitomycin Approved 50-07-7 5746
Sodium citrate Approved, Investigational 68-04-2 23431961
Dexmedetomidine Approved, Experimental, Vet_approved 86347-14-0, 113775-47-6 68602 5311068
Ropivacaine Approved 84057-95-4 71273 175805
Sufentanil Approved, Investigational 56030-54-7 41693
Diazepam Approved, Illicit, Investigational, Vet_approved 439-14-5 3016
Povidone-iodine Approved 25655-41-8

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Fibrinolytic Therapy Versus Medical Thoracoscopy for Treatment of Severe Pleural Infection: A Randomized Clinical Trial Completed NCT03213834 Phase 4 tPA;DNase
2 A Prospective, Randomized, Double Blind, Controlled Trial to Evaluate Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Pleural Empyema Completed NCT01246453 Phase 4 Intrapleurally Alteplase vs Intrapleurally Urokinase
3 Intrapleural Tissue Plasminogen Activator and Deoxyribonuclease Therapy Versus Early Medical Thoracoscopy for Treatment of Pleural Infection: A Randomized Clinical Trial Completed NCT03468933 Phase 4 tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase)
4 A Comparative Study Between Thoracic Epidural Anesthesia in Non-Intubated Video-Assisted Thoracoscopes and the Conventional General Anesthesia With One Lung Ventilation Active, not recruiting NCT05077111 Phase 4
5 Rigid Versus Semirigid Thoracoscopy in Diagnosing Pleural Diseases: a Randomized Study Completed NCT01366261 Phase 3
6 Cryobiopsy or Forceps Biopsy During Semirigid Thoracoscopy: a Comparative Study Completed NCT01475084 Phase 2, Phase 3
7 A Phase I/II Clinical Trial of Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin Active, not recruiting NCT02414269 Phase 1, Phase 2 cyclophosphamide;pembrolizumab
8 Light Dosimetry for Intraoperative Photodynamic Therapy (IO-PDT) With Porfimer Sodium (Photofrin) in Patients With Malignant Mesothelioma or Non-Small Cell Lung Cancer (NSCLC), or Other Malignancies With Pleural Disease - Phase I Study Recruiting NCT03678350 Phase 1 Porfimer Sodium
9 Utilizing Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-Small Cell Lung Cancer (NSCLC) With Pleural Disease - Phase I Study Recruiting NCT04836429 Phase 1 Porfimer Sodium;Photodynamic Therapy
10 Multicenter, International Online Documentation of Indications and Results of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC Und PITAC) for Treating Malignant Peritoneal and Pleural Diseases Unknown status NCT03210298
11 Confocal Laser Endomicroscopy in Pleural Malignancies: A Comparison With Pathology Unknown status NCT03290183
12 Suturing With U-technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube Drain - A Single-centre Open-label Randomized Prospective Trial (SUTURE TRIAL) Unknown status NCT04193241
13 Can High Frequency Transthoracic Sonography Play a Competition Role With High Resolution Computed Tomography in Assessment of Alveolar Intersitial Syndrome Unknown status NCT03172585
14 Talc Outpatient Pleurodesis With Indwelling Catheter: A Randomized Controlled Trial Unknown status NCT03973957 Fentanyl Citrate;Talc Slurry
15 Liquid Biopsy With Immunomagnetic Beads Capture Technique for Malignant Cell Detection in Body Fluid Unknown status NCT02891642
16 How Should be Invasive Diagnostic Algorithm in Pleural Diseases Completed NCT03153501
17 Invasive Methods in the Diagnosis of Pleural Diseases Completed NCT05428891
18 Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy For Diagnosis of Patients With Pleural Effusions: A Randomized Control Trial Completed NCT00720954
19 Pleural Disease: Phenotypes, Diagnostic Yield and Outcomes Completed NCT03922841
20 Fibrinolytic Therapy Versus Medical Thoracoscopy for Treatment of Pleural Infection: A Randomized Clinical Trial Completed NCT02973139
21 The Diagnosis and Mechanism of Pleural Effusion Completed NCT03997669
22 Impact of Respiratory Physiotherapy in the Management of Infectious Pleural Effusion Completed NCT02359383
23 The Effect on Respiratory Function of Monitored Anesthesia Care With Dexmedetomidine in Patients Undergoing Diagnostic or Therapeutic Pleuroscopy Completed NCT03597828
24 Safety of Thoracoscopy in Patients With High Risk Completed NCT01193439
25 Pleural Cryobiopsies During Semirigid Thoracoscopy: A New Technique Completed NCT01472172 Early Phase 1
26 Vacuum vs Manual Drainage During Unilateral Thoracentesis: A Randomized Trial Completed NCT03496987
28 Analgesic Non Inferiority of the Thoracic Bi-block Combining an Erector Spinae Muscle Plane Block and a Serratus Anterior Muscle Plane Block in Comparison With Thoracic Epidural for Video-Assisted Thoracic Surgery. Completed NCT04538235
29 Outcome of Patients Who Could Not Have Been Diagnosed by Medical Thoracoscopy Completed NCT01356979
30 An Open Labeled Clinical Trial of Medical Device, for Diagnosis and Classification of Pleural Diseases Using Ultrasound Channel Data, While Minimizing Sampling Rate and Data Volume Recruiting NCT04418804
31 Mini Invasive Probe Based Confocal Laser Endomicroscopy of the Pleura for Malignancies Diagnosis Recruiting NCT04731129
32 Risk of 24 Hour-pneumothorax After Chest Tube Removal With and Without Chest Tube Clamping in Patients With Pleural Pathology at the National Institute of Respiratory Diseases Recruiting NCT05243316
33 Thoracoscopic Treatment of Primary Pneumothorax - A National Randomised Controlled Trial Recruiting NCT02866305 Early Phase 1 Epidural
34 A Randomized, Double Blinded, Controlled Trial of a Rapid Pleurodesis Protocol After Indwelling Pleural Catheter Placement for Malignant Pleural Effusions Terminated NCT03325192 Rapid pleurodesis protocol
35 Optical Coherence Tomography of Airway and Pleural Disorders Withdrawn NCT00580892

Search NIH Clinical Center for Pleural Disease

Cochrane evidence based reviews: pleural diseases

Genetic Tests for Pleural Disease

Anatomical Context for Pleural Disease

Organs/tissues related to Pleural Disease:

MalaCards : Lung, Heart, T Cells, Breast, Lymph Node, Bone Marrow, Endothelial

Publications for Pleural Disease

Articles related to Pleural Disease:

(show top 50) (show all 1530)
# Title Authors PMID Year
Novel 3D organotypic co-culture model of pleura. 62 41
36454800 2022
Retrospective review comparing intrapleural fibrinolytic therapy (alteplase) and surgical intervention in complex pleural effusion. 41
36419155 2022
Novel method for bronchial stump coverage for prevents postpneumonectomy bronchopleural fistula: pedicled thymopericardial fat flap. 41
36369041 2022
Evaluation of adenosine deaminase activity in the Mycobacterium tuberculosis culture supernatants. 53 62
10596453 1999
PET/CT Showing a Case of Langerhans Cell Histiocytosis Involving the Pleura. 62
36469071 2023
Prevalence of Pulmonary Diseases in Association with Inflammatory Bowel Disease. 62
35142913 2022
Role of Prosaposin and Extracellular Sulfatase Sulf-1 Detection in Pleural Effusions as Diagnostic Biomarkers of Malignant Mesothelioma. 62
36359323 2022
FDG PET/CT for Staging and Restaging Malignant Mesothelioma. 62
35965111 2022
Differentiating malignant pleural mesothelioma and metastatic pleural disease based on a machine learning model with primary CT signs: A multicentre study. 62
36387542 2022
Diagnosis of malignant pleural disease: Ultrasound as "a detective probe". 62
36415167 2022
Imaging Approach to Disease of the Pleura. 62
35738911 2022
Squamous Cell Carcinoma of the Lung Presenting Unilateral Thoracic Hyperhidrosis: A Case Report and Review of Literature. 62
36261372 2022
Utility of high-frequency B-mode and contrast-enhanced ultrasound for the differential diagnosis of benign and malignant pleural diseases: a prospective study. 62
36389309 2022
Local Anaesthetic Thoracoscopy for Pleural Effusion-A Narrative Review. 62
36292425 2022
Subtotal Pleurectomy with Intrathoracic Chemo Hyperthermia (HITHOC) for IVa Thymomas: De Novo Versus Recurrent Pleural Disease. 62
36291819 2022
IgG4 related pleural disease: Recurrent pleural effusion after COVID-19 vaccination. 62
36187460 2022
Implementation of evidence on management of pleural diseases: insights from a territory-wide survey of clinicians in Hong Kong. 62
36280817 2022
Application of Contrast-Enhanced Ultrasound to Detect Hepatic Hydrothorax in Patients with Liver Cirrhosis. 62
32674185 2022
Thoracic surgery in the Netherlands. 62
36389315 2022
Lung Ultrasonography for COVID-19 Patients in Out of Hospital Settings. 62
35032294 2022
Pleural Disease in Acute COVID-19 Pneumonia: A Single Center Retrospective Cohort Study. 62
36190553 2022
Radiographic findings useful for diagnosis of primary chest wall lymphoma without preceding pleural disease: A case report. 62
35992553 2022
Mediastinal metastases from a primary immature teratoma of the CNS. 62
35855860 2022
Precut technique using an injection needle: A retrospective study on a new ancillary procedure for pleural biopsy. 62
35945762 2022
Management of Malignant Pleural Effusion: Where Are We Now? 62
35613947 2022
Multiple rib fractures confused with loss of lung volume on chest X-ray. 62
35990378 2022
Artichoke phytocomplex modulates serum microRNAs in patients exposed to asbestos: a first step of a phase II clinical trial. 62
35987988 2022
Lung cancer and mesothelioma risks in a prospective cohort of workers with asbestos-related lung or pleural diseases. 62
35642773 2022
Bronchial mucus plug mimicking fragmented Ascaris worm: An ambiguous case presentation. 62
36387681 2022
Malignant pleural disease: a pragmatic guide to diagnosis. 62
35749791 2022
Treating Recurrent Pleural Disease: A Review of Indications and Technique for Chemical Pleurodesis for the Interventional Radiologist. 62
36062225 2022
Surgical Management of Pneumothorax and Pleural Space Disease. 62
35671764 2022
[Improve the clinical research and standardize the management of pleural diseases]. 62
35701089 2022
The Frequency, Risk Factors, and Management of Complications From Pleural Procedures. 62
34896096 2022
Intrapleural interleukin-2-expressing oncolytic virotherapy enhances acute antitumor effects and T-cell receptor diversity in malignant pleural disease. 62
33485667 2022
Two years progression-free survival under vinorelbine metronomic therapy of a patient with metastatic epithelioid hemangioendothelioma. 62
35385926 2022
Synchronous metastatic lung adenocarcinoma and marginal B-cell lymphoma presenting as pleural nodules. 62
35232744 2022
The Use of Chest Magnetic Resonance Imaging in Malignant Pleural Mesothelioma Diagnosis. 62
35328305 2022
Quantitative Assessment of Asbestos Fibers in Normal and Pathological Pleural Tissue-A Scoping Review. 62
35207583 2022
Diagnostic pitfalls in computed tomography of the chest. 62
35171051 2022
An international survey on the use of intrapleural tissue plasminogen activator/DNase therapy for pleural infection. 62
35141321 2022
Analysis of Spanish doctoral theses on pleural diseases. 62
34366283 2022
Indwelling pleural catheters: evidence for and management. 62
35064052 2022
The role of interventional pulmonology in pleural disease diagnosis and management. 62
34698676 2022
Radiation strategy and techniques for metastatic pleural disease from thymic malignancies: extended abstract. 62
36164364 2022
Silicosis-related pleural effusion diagnosed using elemental analysis of the pleural fluid cell block: A case report. 62
35601868 2022
Objective Thoracoscopic Criteria in Differentiation between Benign and Malignant Pleural Effusions. 62
34515216 2022
Respiratory system toxicity induced by immune checkpoint inhibitors: A real-world study based on the FDA adverse event reporting system database. 62
36059699 2022
Joining Forces: How to Coordinate Large, Multicenter Randomized Trials. 62
34774181 2021
Thoracic involvement and imaging patterns in IgG4-related disease. 62
34615698 2021

Variations for Pleural Disease

Expression for Pleural Disease

Search GEO for disease gene expression data for Pleural Disease.

Pathways for Pleural Disease

Pathways related to Pleural Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.93 MIRLET7A1 MIR29C MIR29B1 MIR223 MIR21 MIR17
2 10.65 MIRLET7A1 MIR32 MIR29B1

GO Terms for Pleural Disease

Cellular components related to Pleural Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.03 MSLN MIRLET7A1 MIR625 MIR30E MIR29C MIR29B1
2 RISC complex GO:0016442 9.74 MIR125A MIR125B1 MIR138-1 MIR142 MIR17 MIR21
3 extracellular vesicle GO:1903561 9.61 MIRLET7A1 MIR30E MIR29C MIR29B1 MIR21 MIR193A

Biological processes related to Pleural Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.12 MIR29B1 MIR223 MIR21 MIR17 MIR125A CRP
2 negative regulation of gene expression GO:0010629 9.97 MIR29C MIR29B1 MIR21 MIR17 MIR125B1 MIR125A
3 negative regulation of inflammatory response GO:0050728 9.95 ADA MIR138-1 MIR142 MIR223
4 negative regulation of cell migration GO:0030336 9.95 MIR29C MIR29B1 MIR21 MIR138-1 FLCN
5 negative regulation of protein kinase B signaling GO:0051898 9.89 MIR29C MIR29B1 FLCN
6 negative regulation of angiogenesis GO:0016525 9.8 MIR125A MIR125B1 MIR193A MIR21 MIR29C
7 negative regulation of osteoblast differentiation GO:0045668 9.78 MIR17 MIR138-1 MIR125B1
8 positive regulation of fat cell differentiation GO:0045600 9.77 MIR29B1 MIR21 MIR17
9 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.76 MIR29C MIR29B1 MIR193A
10 miRNA-mediated gene silencing GO:0035195 9.74 MIRLET7A1 MIR625 MIR32 MIR30E MIR29C MIR29B1
11 negative regulation of NIK/NF-kappaB signaling GO:1901223 9.71 MIR29B1 MIR223 MIR21
12 negative regulation of sprouting angiogenesis GO:1903671 9.67 MIR30E MIR17 MIR138-1
13 negative regulation of vascular endothelial cell proliferation GO:1905563 9.63 MIR30E MIR29C MIR193A
14 negative regulation of cytokine-mediated signaling pathway GO:0001960 9.61 MIR29B1 MIR21 MIR125A
15 negative regulation of receptor signaling pathway via STAT GO:1904893 9.57 MIR125B1 MIR125A
16 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 9.56 MIR29C MIR29B1
17 positive regulation of vascular associated smooth muscle cell differentiation GO:1905065 9.52 MIR21 MIR125B1
18 negative regulation of circulating fibrinogen levels GO:0061754 9.51 MIR29C MIR29B1
19 negative regulation of interleukin-6-mediated signaling pathway GO:0070104 9.5 MIRLET7A1 MIR125B1 MIR125A
20 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.5 MIR125B1 MIR138-1 MIR17 MIR21 MIR29B1 MIR29C
21 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.43 MIR21 MIR17 MIR138-1
22 positive regulation of metalloendopeptidase activity GO:1904685 9.33 MIR29B1 MIR21 MIR17

Molecular functions related to Pleural Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.65 MIR29C MIR29B1 MIR223 MIR21 MIR193A MIR17
2 mRNA base-pairing translational repressor activity GO:1903231 9.44 MIRLET7A1 MIR32 MIR30E MIR29C MIR29B1 MIR223

Sources for Pleural Disease

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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