MCID: PLR022
MIFTS: 45

Pleural Disease

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Pleural Disease

MalaCards integrated aliases for Pleural Disease:

Name: Pleural Disease 12 15
Pleural Diseases 54 44 70
Non-Neoplastic Pleural Disorder 70
Non-Neoplastic Pleural Disease 12
Abnormality of the Pleura 29
Disorder of Pleura 12
Pleural Disorders 42

Classifications:



External Ids:

Disease Ontology 12 DOID:1532
MeSH 44 D010995
NCIt 50 C26859
SNOMED-CT 67 88075009
ICD10 32 Q34.0
UMLS 70 C0032226 C1335034

Summaries for Pleural Disease

MedlinePlus : 42 Your pleura is a large, thin sheet of tissue that wraps around the outside of your lungs and lines the inside of your chest cavity. Between the layers of the pleura is a very thin space. Normally it's filled with a small amount of fluid. The fluid helps the two layers of the pleura glide smoothly past each other as your lungs breathe air in and out. Disorders of the pleura include Pleurisy - inflammation of the pleura that causes sharp pain with breathing Pleural effusion - excess fluid in the pleural space Pneumothorax - buildup of air or gas in the pleural space Hemothorax - buildup of blood in the pleural space Many different conditions can cause pleural problems. Viral infection is the most common cause of pleurisy. The most common cause of pleural effusion is congestive heart failure. Lung diseases, like COPD, tuberculosis, and acute lung injury, cause pneumothorax. Injury to the chest is the most common cause of hemothorax. Treatment focuses on removing fluid, air, or blood from the pleural space, relieving symptoms, and treating the underlying condition. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Pleural Disease, also known as pleural diseases, is related to mesothelioma, malignant and malignant pleural mesothelioma, and has symptoms including dyspnea, apnea and snoring. An important gene associated with Pleural Disease is ADA (Adenosine Deaminase), and among its related pathways/superpathways are MicroRNAs in cancer and Alzheimers Disease. The drugs Fibrinolytic Agents and Plasminogen have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and bone.

Disease Ontology : 12 A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism.

Wikipedia : 73 Pleural disease occurs in the pleural space, which is the thin fluid-filled area in between the two... more...

Related Diseases for Pleural Disease

Diseases related to Pleural Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 mesothelioma, malignant 30.8 MSLN MIRLET7B MIR625 MIR32 MIR29C
2 malignant pleural mesothelioma 30.7 MSLN MIR625 MIR411 MIR223 MIR193A MIR17
3 immune deficiency disease 29.8 MIR223 MIR17 MIR125B1 MIR125A H2AC18 ADA
4 lung cancer 29.4 MIRLET7B MIRLET7A1 MIR708 MIR625 MIR32 MIR30E
5 ovarian cancer 29.3 MSLN MIRLET7A1 MIR30E MIR29C MIR223 MIR193A
6 pleural cancer 29.3 MSLN MIRLET7A1 MIR625 MIR411 MIR32 MIR30E
7 pneumothorax 11.0
8 pleurisy 11.0
9 chylothorax, congenital 10.9
10 benign mesothelioma 10.5
11 pericardial mesothelioma 10.4 MIR32 MIR17
12 mature t-cell and nk-cell lymphoma 10.3 MIR17 H2AC18 CXCL13
13 central nervous system benign neoplasm 10.3 MIRLET7B MIR125B1 H2AC18
14 tongue disease 10.3 MIR193A MIR17 MIR138-1
15 pre-malignant neoplasm 10.3 MIR193A MIR17 H2AC18
16 pleural empyema 10.3
17 in situ carcinoma 10.3 MIR193A MIR17 H2AC18
18 primary bacterial infectious disease 10.3 MIR223 MIR125A H2AC18 ADA
19 autoimmune disease of gastrointestinal tract 10.3 MIR223 MIR125B1 H2AC18
20 thyroid gland disease 10.3 MIR17 MIR138-1 MIR125A H2AC18
21 mature b-cell neoplasm 10.3 MIR17 MIR125A H2AC18
22 splenic tuberculosis 10.3 MSLN ADA
23 autonomic nervous system neoplasm 10.3 MIR193A MIR17 MIR125A H2AC18
24 peripheral nervous system neoplasm 10.3 MIR193A MIR17 MIR125A H2AC18
25 autoimmune disease of musculoskeletal system 10.3 MIR223 MIR17 MIR125A H2AC18
26 cell type benign neoplasm 10.3 MIR193A MIR17 MIR125A H2AC18
27 bone sarcoma 10.3 MIR193A MIR17 H2AC18
28 bile duct adenocarcinoma 10.3 MIR30E MIR17 MIR125A H2AC18
29 oral cavity cancer 10.3 MIRLET7B MIR193A MIR17 H2AC18
30 chromosomal deletion syndrome 10.3 MIR223 MIR17 H2AC18
31 bile duct disease 10.3 MIR30E MIR17 MIR125A H2AC18
32 overnutrition 10.3 MIR223 MIR17 MIR125A H2AC18
33 bone cancer 10.3 MIR193A MIR17 MIR125A H2AC18
34 glucose metabolism disease 10.3 MIR223 MIR17 MIR125A H2AC18
35 sezary's disease 10.3 MIRLET7A1 MIR223 MIR17
36 biliary tract disease 10.3 MIR30E MIR17 MIR125A H2AC18
37 pleuropulmonary blastoma 10.3 MIRLET7B MIRLET7A1 MIR708 MIR125B1 MIR125A
38 cervix disease 10.3 MIR29C MIR193A MIR17 MIR125A H2AC18
39 bone marrow cancer 10.3 MIR30E MIR17 MIR125A H2AC18
40 leukocyte disease 10.3 MIR17 MIR125A H2AC18
41 malignant astrocytoma 10.3 MIR193A MIR17 MIR125B1 MIR125A H2AC18
42 esophageal disease 10.3 MIR223 MIR193A MIR17 MIR125A H2AC18
43 bone inflammation disease 10.3 MIR223 MIR17 MIR125B1 MIR125A H2AC18
44 melanoma, uveal 10.3 MIRLET7B MIR29C MIR125A H2AC18
45 ovarian disease 10.2 MIRLET7B MIRLET7A1 MIR223 MIR17 MIR125B1
46 breast disease 10.2 MIR193A MIR17 MIR125B1 MIR125A H2AC18
47 retinal cancer 10.2 MIRLET7B MIR193A MIR17 MIR125A H2AC18
48 ocular cancer 10.2 MIRLET7B MIR193A MIR17 MIR125A H2AC18
49 asbestosis 10.2
50 asbestos intoxication 10.2

Graphical network of the top 20 diseases related to Pleural Disease:



Diseases related to Pleural Disease

Symptoms & Phenotypes for Pleural Disease

UMLS symptoms related to Pleural Disease:


dyspnea; apnea; snoring; coughing; pleuritic pain

Drugs & Therapeutics for Pleural Disease

Drugs for Pleural Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrinolytic Agents Phase 4
2 Plasminogen Phase 4
3 Tissue Plasminogen Activator Phase 4
4
Nitrous oxide Approved, Vet_approved Phase 2, Phase 3 10024-97-2 948
5
Acetaminophen Approved Phase 1, Phase 2 103-90-2 1983
6
Diphenhydramine Approved, Investigational Phase 1, Phase 2 147-24-0, 58-73-1 3100
7
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
8
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
9
Promethazine Approved, Investigational Phase 1, Phase 2 60-87-7 4927
10 Immunologic Factors Phase 1, Phase 2
11 Antirheumatic Agents Phase 1, Phase 2
12 Antiemetics Phase 1, Phase 2
13 Antineoplastic Agents, Immunological Phase 1, Phase 2
14 Immunosuppressive Agents Phase 1, Phase 2
15 Alkylating Agents Phase 1, Phase 2
16
Trioxsalen Approved Phase 1 3902-71-4 5585
17 Ether Phase 1
18 Photosensitizing Agents Phase 1
19 Dihematoporphyrin Ether Phase 1
20 Dermatologic Agents Phase 1
21 Hematoporphyrin Derivative Phase 1
22
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
23
Dexmedetomidine Approved, Vet_approved 113775-47-6 68602 5311068
24
Midazolam Approved, Illicit 59467-70-8 4192
25
Ropivacaine Approved 84057-95-4 71273 175805
26
Diazepam Approved, Illicit, Investigational, Vet_approved 439-14-5 3016
27
Sufentanil Approved, Investigational 56030-54-7 41693
28
Lidocaine Approved, Vet_approved 137-58-6 3676
29
Cisplatin Approved 15663-27-1 84093 441203 2767
30
Paclitaxel Approved, Vet_approved 33069-62-4 36314
31
Oxaliplatin Approved, Investigational 61825-94-3 5310940 9887054 6857599 43805
32
Doxorubicin Approved, Investigational 23214-92-8 31703
33
Gemcitabine Approved 95058-81-4 60750
34
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
35
Sodium citrate Approved, Investigational 68-04-2
36
Povidone-iodine Approved 25655-41-8
37
Iodine Approved, Investigational 7553-56-2 807
38
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
39
Cadexomer iodine Experimental 94820-09-4
40 Viscosupplements
41 Adjuvants, Immunologic
42 Protective Agents
43 Tea
44 Albumin-Bound Paclitaxel
45
Liposomal doxorubicin 31703
46 Mitomycins
47 Narcotics
48 Anesthetics, General
49 Citrate
50 Anesthetics, Intravenous

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Fibrinolytic Therapy Versus Medical Thoracoscopy for Treatment of Severe Pleural Infection: A Randomized Clinical Trial Completed NCT03213834 Phase 4 tPA;DNase
2 A Prospective, Randomized, Double Blind, Controlled Trial to Evaluate Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Pleural Empyema Completed NCT01246453 Phase 4 Intrapleurally Alteplase vs Intrapleurally Urokinase
3 Intrapleural Tissue Plasminogen Activator and Deoxyribonuclease Therapy Versus Early Medical Thoracoscopy for Treatment of Pleural Infection: A Randomized Clinical Trial Completed NCT03468933 Phase 4 tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase)
4 Rigid Versus Semirigid Thoracoscopy in Diagnosing Pleural Diseases: a Randomized Study Completed NCT01366261 Phase 3
5 Cryobiopsy or Forceps Biopsy During Semirigid Thoracoscopy: a Comparative Study Completed NCT01475084 Phase 2, Phase 3
6 A Phase I/II Clinical Trial of Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin Recruiting NCT02414269 Phase 1, Phase 2 cyclophosphamide;pembrolizumab
7 Light Dosimetry for Intraoperative Photodynamic Therapy (IO-PDT) With Porfimer Sodium (Photofrin?) in Patients With Malignant Mesothelioma or Non-Small Cell Lung Cancer (NSCLC) With Pleural Disease - Phase I Study Not yet recruiting NCT03678350 Phase 1 Porfimer Sodium
8 Impact of Respiratory Physiotherapy in the Management of Infectious Pleural Effusion Unknown status NCT02359383
9 Can High Frequency Transthoracic Sonography Play a Competition Role With High Resolution Computed Tomography in Assessment of Alveolar Intersitial Syndrome Unknown status NCT03172585
10 Confocal Laser Endomicroscopy in Pleural Malignancies: A Comparison With Pathology Unknown status NCT03290183
11 Safety of Thoracoscopy in Patients With High Risk Completed NCT01193439
12 Outcome of Patients Who Could Not Have Been Diagnosed by Medical Thoracoscopy Completed NCT01356979
13 PREDICTING MALIGNANT MESOTHELIOMA BY ANALYZING HYALURONAN, OSTEOPONTIN, C-ERC/MESOTHELIN, N-ERC/MESOTHELIN AND SYNDECAN-1 SERUM LEVELS Completed NCT02029105
14 How Should be Invasive Diagnostic Algorithm in Pleural Diseases Completed NCT03153501
15 ULTRASONOGRAPHY GUIDED PLEURAL NEEDLE BIOPSY VERSUS COMPUTED TOMOGRAPHY GUIDED ABRAMS PLEURAL NEEDLE BIOPSY FOR DIAGNOSIS OF PATIENTS WITH PLEURAL EFFUSIONS: A RANDOMIZED CONTROLLED TRIAL Completed NCT01196585
16 The Effect on Respiratory Function of Monitored Anesthesia Care With Dexmedetomidine in Patients Undergoing Diagnostic or Therapeutic Pleuroscopy Completed NCT03597828
17 Vacuum vs Manual Drainage During Unilateral Thoracentesis: A Randomized Trial Completed NCT03496987
18 Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy For Diagnosis of Patients With Pleural Effusions: A Randomized Control Trial Completed NCT00720954
19 Fibrinolytic Therapy Versus Medical Thoracoscopy for Treatment of Pleural Infection: A Randomized Clinical Trial Completed NCT02973139
20 Analgesic Non Inferiority of the Thoracic Bi-block Combining an Erector Spinae Muscle Plane Block and a Serratus Anterior Muscle Plane Block in Comparison With Thoracic Epidural for Video-Assisted Thoracic Surgery. Completed NCT04538235
21 Pleural Cryobiopsies During Semirigid Thoracoscopy: A New Technique Completed NCT01472172 Early Phase 1
22 Multicenter, International Online Documentation of Indications and Results of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC Und PITAC) for Treating Malignant Peritoneal and Pleural Diseases Recruiting NCT03210298
23 Pleural Disease: Phenotypes, Diagnostic Yield and Outcomes Recruiting NCT03922841
24 Mini Invasive Probe Based Confocal Laser Endomicroscopy of the Pleura for Malignancies Diagnosis Recruiting NCT04731129
25 Suturing With U-technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube Drain - A Single-centre Open-label Randomized Prospective Trial (SUTURE TRIAL) Recruiting NCT04193241
26 Thoracoscopic Treatment of Primary Pneumothorax - A National Randomised Controlled Trial Recruiting NCT02866305 Early Phase 1 Epidural
27 Liquid Biopsy With Immunomagnetic Beads Capture Technique for Malignant Cell Detection in Body Fluid Recruiting NCT02891642
28 Talc Outpatient Pleurodesis With Indwelling Catheter: A Randomized Controlled Trial Recruiting NCT03973957 Fentanyl Citrate;Talc Slurry
29 Impact of Gated PET/CT on the Diagnosis of Distant Metastases of Advanced Epithelial Ovarian, Fallopian Tube, and Primary Peritoneal Cancer Active, not recruiting NCT02258165
30 The Diagnosis and Mechanism of Pleural Effusion Active, not recruiting NCT03997669
31 An Open Labeled Clinical Trial of Medical Device, for Diagnosis and Classification of Pleural Diseases Using Ultrasound Channel Data, While Minimizing Sampling Rate and Data Volume Not yet recruiting NCT04418804
32 A Randomized, Double Blinded, Controlled Trial of a Rapid Pleurodesis Protocol After Indwelling Pleural Catheter Placement for Malignant Pleural Effusions Terminated NCT03325192 Rapid pleurodesis protocol
33 Optical Coherence Tomography of Airway and Pleural Disorders Withdrawn NCT00580892

Search NIH Clinical Center for Pleural Disease

Cochrane evidence based reviews: pleural diseases

Genetic Tests for Pleural Disease

Genetic tests related to Pleural Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Pleura 29

Anatomical Context for Pleural Disease

MalaCards organs/tissues related to Pleural Disease:

40
Lung, Heart, Bone, Breast, Bone Marrow, Thyroid, T Cells

Publications for Pleural Disease

Articles related to Pleural Disease:

(show top 50) (show all 1423)
# Title Authors PMID Year
1
Analysis of Risk Factors for Bronchopleural Fistula after Surgical Treatment of Lung Cancer. 42
32224595 2020
2
Pleural complications in patients with coronavirus disease 2019 (COVID-19): how to safely apply and follow-up with a chest tube during the pandemic? 42
33164094 2020
3
Radiographic Changes in Colombian Asbestos Factory Workers. 42
31934550 2020
4
Evaluation of adenosine deaminase activity in the Mycobacterium tuberculosis culture supernatants. 61 54
10596453 1999
5
HΜGB1/sRAGE levels differ significantly between transudates and exudates. 61
33607399 2021
6
The role of nitric oxide in pleural disease. 61
33662805 2021
7
A retrospective study on the combined biomarkers and ratios in serum and pleural fluid to distinguish the multiple types of pleural effusion. 61
33740937 2021
8
Complete pleural symphysis is predicted by a blunted costophrenic angle. 61
32997236 2021
9
Advances in pleural infection and malignancy. 61
33650525 2021
10
Thoracic Endemic Fungi in the United States: Importance of Patient Location. 61
33544664 2021
11
A case of diffuse large B-cell lymphoma originating from chest wall complicated by benign asbestos pleural effusion. 61
33552521 2021
12
Characterization of DLBCL with a PMBL gene expression signature. 61
33684939 2021
13
Emerging challenges in the evaluation of fever in cancer patients at risk of febrile neutropenia in the era of COVID-19: a MASCC position paper. 61
33230644 2021
14
Probe-based confocal laser endomicroscopy for pleural malignancies diagnosis. 61
33001538 2021
15
Ultrasound for Pleural Disease: Beyond a Pocket of Pleural Fluid. 61
33621161 2021
16
Refractory IgG4-related Pleural Disease with Chylothorax: A Case Report and Literature Review. 61
33518567 2021
17
Interventional Pulmonology: Diagnostic and Therapeutic Advances in Bronchoscopy. 61
33590989 2021
18
Evaluation of the efficacy and safety of a new flex-rigid pleuroscope. 61
32949105 2021
19
Diagnostic utility of medical thoracoscopy in T cell lymphoblastic lymphoma presenting with pleural effusion. 61
33425676 2021
20
Thoracic Manifestations of Rheumatoid Arthritis. 61
33411607 2021
21
Improving the care of patients with pleural disease. 61
33529107 2021
22
Circulating and local nuclear expression of survivin and fibulin-3 genes in discriminating benign from malignant respiratory diseases: correlation analysis. 61
33226065 2021
23
Diagnostics in Pleural Disease. 61
33291748 2020
24
Rheumatoid arthritis-related lung disease detected on clinical chest computed tomography imaging: Prevalence, risk factors, and impact on mortality. 61
33059295 2020
25
Intrapleural interleukin-2-expressing oncolytic virotherapy enhances acute antitumor effects and T-cell receptor diversity in malignant pleural disease. 61
33485667 2020
26
Management of Indwelling Tunneled Pleural Catheters: A Modified Delphi Consensus Statement. 61
32561437 2020
27
Technique of pressurized intrathoracic aerosol chemotherapy (PITAC) for malignant pleural effusion. 61
33575461 2020
28
Pleural diseases and COVID-19: ubi fumus, ibi ignis. 61
32943411 2020
29
Cerebral Air Embolism After Pleural Lavage for Empyema. 61
32246936 2020
30
Medical thoracoscopy in the diagnosis of pleural disease: a guide for the clinician. 61
32588676 2020
31
Radiographic change over 11 years in a patient with asbestos-related pleural disease. 61
32832086 2020
32
IgG4-related pleural disease with aortitis and submandibular glands involvement successfully treated with corticosteroid: case-based review. 61
32206878 2020
33
Xanthogranulomatous pleuritis - An unusual presentation of tuberculosis. 61
33323663 2020
34
Video-assisted thoracic surgery in the primary management of advanced ovarian carcinoma with moderate to large pleural effusions: A Memorial Sloan Kettering Cancer Center Team Ovary Study. 61
32792282 2020
35
Chronic Pulmonary Diseases and COVID-19. 61
33031727 2020
36
Correlation between CT findings and thoracoscopic diagnosis in diffuse pleural disease. 61
32921755 2020
37
Pleural effusions and pneumothorax: Beyond simple plumbing: Expert opinions on knowledge gaps and essential next steps. 61
32613624 2020
38
Influenza virus infection complicated by bacterial necrotising pneumonia: two case reports. 61
32281523 2020
39
Clinical feature of diagnostic challenging cases for pleural biopsy in patient with malignant pleural mesothelioma. 61
31981139 2020
40
Pleural Disease Management: Manometry-guided Thoracentesis, Optimal Drainage Regimen of Indwelling Pleural Catheters, and Talc Poudrage versus Slurry for Malignant Pleural Effusion. 61
32421351 2020
41
Surgical Pulmonary and Pleural Diseases in Children: Lung Malformations, Empyema, and Spontaneous Pneumothorax. 61
32591058 2020
42
Clinical manifestations and epidemiology of adolescent tuberculosis in Ukraine. 61
32964003 2020
43
[Five Years PLEURATUMOR Register of the German Society of Thoracic Surgery]. 61
32629507 2020
44
Pleural translocation and lesions by pulmonary exposed multi-walled carbon nanotubes. 61
32764839 2020
45
Convex probe endobronchial ultrasound guided transbronchial/transoesophageal fine needle aspiration (C-EBUS-TBNA/EUS-B FNA) of pleural lesions: A single center experience and review of literature. 61
32657108 2020
46
Application of Contrast-Enhanced Ultrasound to Detect Hepatic Hydrothorax in Patients with Liver Cirrhosis. 61
32674185 2020
47
Image-guided catheter drainage in loculated pleural space collections, effectiveness, and complications. 61
32643640 2020
48
Evaluating the impact of nurse practitioner involvement in a pleural procedures clinic. 61
32697643 2020
49
Fluid Infusion Through Chest Tube to Facilitate Pleural Procedures: A Feasibility Study. 61
31876537 2020
50
Utility of medical thoracoscopy in diagnosis and treatment of hemothorax due to carcinoma: A case report. 61
32930145 2020

Variations for Pleural Disease

Expression for Pleural Disease

Search GEO for disease gene expression data for Pleural Disease.

Pathways for Pleural Disease

Pathways related to Pleural Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.81 MIRLET7B MIRLET7A1 MIR625 MIR32 MIR30E MIR29C
2 11.63 MIR708 MIR138-1 MIR125B1 MIR125A
3 10.58 MIRLET7B MIRLET7A1 MIR29C

GO Terms for Pleural Disease

Cellular components related to Pleural Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 MIRLET7B MIRLET7A1 MIR29C MIR223 MIR17 MIR125B1
2 extracellular space GO:0005615 9.8 MIR411 MIR625 MIRLET7A1 MIRLET7B MSLN ADA
3 extracellular vesicle GO:1903561 9.28 MIR125A MIR125B1 MIR17 MIR193A MIR29C MIR30E

Biological processes related to Pleural Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of inflammatory response GO:0050728 9.67 MIR223 MIR138-1 ADA
2 negative regulation of angiogenesis GO:0016525 9.67 MIR29C MIR193A MIR125B1 MIR125A
3 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.63 MIR29C MIR193A MIR138-1
4 negative regulation of gene expression GO:0010629 9.63 MIR708 MIR29C MIR17 MIR138-1 MIR125A FLCN
5 negative regulation of sprouting angiogenesis GO:1903671 9.58 MIR30E MIR17 MIR138-1
6 negative regulation of vascular endothelial cell proliferation GO:1905563 9.5 MIR30E MIR29C MIR193A
7 negative regulation of STAT cascade GO:1904893 9.48 MIR125B1 MIR125A
8 gene silencing by miRNA GO:0035195 9.47 MIRLET7B MIRLET7A1 MIR708 MIR625 MIR411 MIR32
9 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.43 MIR17 MIR138-1
10 negative regulation of interleukin-6-mediated signaling pathway GO:0070104 9.43 MIRLET7A1 MIR125B1 MIR125A
11 miRNA mediated inhibition of translation GO:0035278 9.35 MIRLET7A1 MIR29C MIR17 MIR138-1 MIR125B1

Molecular functions related to Pleural Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.44 MIRLET7B MIRLET7A1 MIR708 MIR411 MIR32 MIR30E
2 mRNA 3'-UTR binding GO:0003730 9.35 MIR708 MIR29C MIR193A MIR17 MIR125A

Sources for Pleural Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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