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MCID: PLR022
MIFTS: 56

Pleural Disease

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pleural Disease

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MalaCards integrated aliases for Pleural Disease:

Name: Pleural Disease 12 15
Pleural Diseases 55 44 73
Non-Neoplastic Pleural Disorder 73
Non-Neoplastic Pleural Disease 12
Abnormality of the Pleura 29
Disorder of Pleura 12
Pleural Disorders 43

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1532
MeSH 44 D010995
NCIt 50 C26859
SNOMED-CT 68 88075009
ICD10 33 J94.9 Q34.0
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Summaries for Pleural Disease

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MedlinePlus : 43 Your pleura is a large, thin sheet of tissue that wraps around the outside of your lungs and lines the inside of your chest cavity. Between the layers of the pleura is a very thin space. Normally it's filled with a small amount of fluid. The fluid helps the two layers of the pleura glide smoothly past each other as your lungs breathe air in and out. Disorders of the pleura include Pleurisy - inflammation of the pleura that causes sharp pain with breathing Pleural effusion - excess fluid in the pleural space Pneumothorax - buildup of air or gas in the pleural space Hemothorax - buildup of blood in the pleural space Many different conditions can cause pleural problems. Viral infection is the most common cause of pleurisy. The most common cause of pleural effusion is congestive heart failure. Lung diseases, like COPD, tuberculosis, and acute lung injury, cause pneumothorax. Injury to the chest is the most common cause of hemothorax. Treatment focuses on removing fluid, air, or blood from the pleural space, relieving symptoms, and treating the underlying condition. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Pleural Disease, also known as pleural diseases, is related to pleurisy and pneumothorax, and has symptoms including dyspnea, apnea and snoring. An important gene associated with Pleural Disease is ADA (Adenosine Deaminase), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and Selenium Micronutrient Network. The drugs Ketotifen and Histamine have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related phenotypes are homeostasis/metabolism and cellular

Disease Ontology : 12 A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism.

Wikipedia : 76 Pleural tumors may be benign (i.e. solitary fibromas) or malignant in nature. Pleural Mesothelioma is a... more...

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Related Diseases for Pleural Disease

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Diseases related to Pleural Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 pleurisy 32.2 ADA CRP TNF
2 pneumothorax 29.9 FLCN FNIP1 FNIP2 SLC22A4
3 vascular disease 29.8 ALB CRP KNG1 TNF
4 acquired immunodeficiency syndrome 29.7 ALB IL1B TNF
5 sleep apnea 29.5 CHI3L1 CRP IL1B TNF
6 malignant pleural mesothelioma 29.3 BAP1 CALB2 EFEMP1 MSLN SPP1
7 chylothorax, congenital 10.9
8 exudative glomerulonephritis 10.3 IL1B TNF
9 staphylococcal toxic shock syndrome 10.2 IL1B TNF
10 drug reaction with eosinophilia and systemic symptoms 10.2 CRP TNF
11 birt-hogg-dube syndrome 10.2 FLCN FNIP1 FNIP2
12 lung cancer 10.2
13 pulpitis 10.2 IL1B KNG1 TNF
14 rheumatoid lung disease 10.2 IL1B SMUG1 TNF
15 bacterial infectious disease 10.2 CRP IL1B TNF
16 pleural tuberculosis 10.2 ADA TBP TNF
17 lemierre's syndrome 10.2 CRP KNG1 SMUG1
18 burns 10.2 CRP IL1B TNF
19 pericardial tuberculosis 10.2 ADA SMUG1 TBP
20 spondylitis 10.2 CHI3L1 CRP TNF
21 scrub typhus 10.2 CRP IL1B TNF
22 adult-onset still's disease 10.2 CRP IL1B TNF
23 cystitis 10.2 CRP KNG1 TNF
24 perinatal necrotizing enterocolitis 10.2 CRP IL1B TNF
25 palindromic rheumatism 10.2 CRP IL1B TNF
26 lymphatic system disease 10.2 CRP SMUG1 TNF
27 extrinsic cardiomyopathy 10.2 CRP IL1B TNF
28 temporal arteritis 10.2 CRP SMUG1 TNF
29 lymph node disease 10.2 CRP IL1B TNF
30 jejunoileitis 10.2 ALB IL1B TNF
31 extrapulmonary tuberculosis 10.2 ADA IL1B TBP
32 leptospirosis 10.2 CRP IL1B TNF
33 autoimmune myocarditis 10.2 SPP1 TNF
34 kashin-beck disease 10.2 IL1B TNF
35 pulmonary edema 10.1 CRP IL1B TNF
36 lyme disease 10.1 CRP IL1B TNF
37 keratoconjunctivitis sicca 10.1 ALB IL1B TNF
38 chorioamnionitis 10.1 CRP IL1B TNF
39 familial mediterranean fever 10.1 CRP IL1B TNF
40 bone inflammation disease 10.1 CRP IL1B TNF
41 gynandroblastoma 10.1 CALB2 DICER1
42 aortitis 10.1 CRP SMUG1
43 kidney angiomyolipoma 10.1 FLCN FNIP1
44 chlamydia 10.1 CRP IL1B TNF
45 upper respiratory tract disease 10.1 ALB IL1B TNF
46 brain edema 10.1 ALB IL1B KNG1
47 juvenile rheumatoid arthritis 10.1 CRP IL1B TNF
48 hypersensitivity reaction type iii disease 10.1 ALB CRP TNF
49 hemorrhagic fever with renal syndrome 10.1 ALB CRP TNF
50 pericardium disease 10.1 ALB CRP SMUG1

Graphical network of the top 20 diseases related to Pleural Disease:



Diseases related to Pleural Disease
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Symptoms & Phenotypes for Pleural Disease

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UMLS symptoms related to Pleural Disease:


dyspnea, apnea, snoring, pleuritic pain, coughing

MGI Mouse Phenotypes related to Pleural Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ADA ALB BAP1 CRP DICER1 EFEMP1
2 cellular MP:0005384 10.23 ADA ALB BAP1 CHI3L1 CXCL13 DICER1
3 cardiovascular system MP:0005385 10.22 ADA BAP1 CRP DICER1 EFEMP1 FLCN
4 immune system MP:0005387 10.18 ADA BAP1 CHI3L1 CRP CXCL13 DICER1
5 hematopoietic system MP:0005397 10.17 ADA BAP1 CHI3L1 CXCL13 DICER1 EFEMP1
6 mortality/aging MP:0010768 10.1 ADA ALB BAP1 DICER1 EFEMP1 FLCN
7 liver/biliary system MP:0005370 9.87 ADA ALB DICER1 EFEMP1 FNIP1 SPP1
8 muscle MP:0005369 9.76 ADA ALB BAP1 DICER1 EFEMP1 FNIP1
9 neoplasm MP:0002006 9.65 ALB BAP1 DICER1 FLCN FNIP1 FNIP2
10 renal/urinary system MP:0005367 9.23 ADA ALB DICER1 EFEMP1 FLCN FNIP1
Sources

Drugs & Therapeutics for Pleural Disease

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Drugs for Pleural Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 290)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketotifen Approved Phase 4 34580-14-8, 34580-13-7 3827
2
Histamine Approved, Investigational Phase 4,Phase 2,Not Applicable 51-45-6, 75614-87-8 774
3
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 564-25-0 54671203
4
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
5
Tetracycline Approved, Vet_approved Phase 4,Not Applicable 60-54-8 5353990
6
Azithromycin Approved Phase 4,Not Applicable 83905-01-5 55185 447043
7
Clindamycin Approved, Vet_approved Phase 4,Phase 2,Phase 3 18323-44-9 29029
8
Cefazolin Approved Phase 4,Phase 2,Phase 3 25953-19-9 656510 33255
9
Zoledronic acid Approved Phase 4,Phase 2 118072-93-8 68740
10
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
11
Prednisolone phosphate Approved, Vet_approved Phase 4,Not Applicable 302-25-0
12
Methylprednisolone hemisuccinate Approved Phase 4,Not Applicable 2921-57-5
13
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
14
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
15
Ofloxacin Approved Phase 4 82419-36-1 4583
16
Povidone Approved Phase 4,Phase 3 9003-39-8
17
Iodine Approved, Investigational Phase 4,Phase 3,Not Applicable 7553-56-2 807
18
Povidone-iodine Approved Phase 4,Phase 3,Not Applicable 25655-41-8
19
Streptokinase Approved, Investigational Phase 4 9002-01-1
20
Mesna Approved, Investigational Phase 4 3375-50-6 598
21
Prednisolone hemisuccinate Experimental Phase 4,Not Applicable 2920-86-7
22 Anti-Allergic Agents Phase 4
23
Histamine Phosphate Phase 4,Phase 2,Not Applicable 51-74-1 65513
24 Antipruritics Phase 4
25 Histamine H1 Antagonists Phase 4
26 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
27 Dermatologic Agents Phase 4,Phase 1
28 Histamine Antagonists Phase 4,Phase 2,Not Applicable
29 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Antitubercular Agents Phase 4,Phase 2,Phase 3,Not Applicable
31 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
32 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Not Applicable
33 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
34 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
35 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
36 Pulmonary Surfactants Phase 4,Phase 3
37 Respiratory System Agents Phase 4,Phase 3
38 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Plasminogen Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Bone Density Conservation Agents Phase 4,Phase 2
42 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable
43 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
44 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
45 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2
46 Clindamycin palmitate Phase 4,Phase 2,Phase 3
47 Clindamycin phosphate Phase 4,Phase 2,Phase 3
48 Diphosphonates Phase 4,Phase 2
49 Methylprednisolone acetate Phase 4,Not Applicable
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 356)
# Name Status NCT ID Phase Drugs
1 Improving Primary Spontaneous Pneumothorax (PSP) Treatment Techniques in VATS Unknown status NCT01463553 Phase 4
2 The Effect of Chest Tubes Using Active Clearance Technology® on the Incidence of Postoperative Atrial Fibrillation Unknown status NCT02808897 Phase 4
3 Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Unknown status NCT02673840 Phase 4 Ketotifen;Placebo
4 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
5 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
6 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
7 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
8 Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema Completed NCT01246453 Phase 4 Intrapleurally Alteplase vs Intrapleurally Urokinase
9 Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy Completed NCT02446782 Phase 4 Cefazolin
10 Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion Completed NCT01670786 Phase 4
11 Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter Completed NCT00978939 Phase 4
12 Talc Pleurodesis in Patients With Recurrent Malignant Pleural Effusion Completed NCT00789087 Phase 4
13 Non-small Cell Lung Cancer Registry Completed NCT00099541 Phase 4 zoledronic acid
14 Fibrinolytic Therapy Versus Medical Thoracoscopy Recruiting NCT03213834 Phase 4 tPA;DNase
15 Fibrinolysis Compared to Thoracoscopy for Pleural Infection Recruiting NCT03468933 Phase 4 tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase)
16 Early Intrapleural TPA Instillation Versus Late Recruiting NCT03167281 Phase 4
17 Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia Recruiting NCT02618057 Phase 4 Prednisolone;Levofloxacin
18 Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital Not yet recruiting NCT03172052 Phase 4 streptokinase;MESNA (2-mercaptoethane sulfonate Na)
19 Reactor Thoracostomy Not yet recruiting NCT03769727 Phase 4
20 Safety, Efficacy, and Side Effects Study of Interventional Cryotherapy in the Pleural Space("ICE PLS") Terminated NCT00747916 Phase 4
21 Betadine Pleurodesis Via Tunneled Pleural Catheters Withdrawn NCT02975921 Phase 4 Povidone-Iodine
22 Absorbable Mesh Pleurodesis in Thoracoscopic Treatment of Spontaneous Pneumothorax Unknown status NCT01848860 Phase 2, Phase 3
23 Pigtail Catheter Versus Chest Tube in the Management of Traumatic Pneumothorax Unknown status NCT01537289 Phase 3
24 Chest Tube Drainage or Thoracoscopic Surgery for Failed Aspiration of Spontaneous Pneumothorax Unknown status NCT00713362 Phase 2, Phase 3
25 Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax Unknown status NCT00418392 Phase 3
26 Pleural Abrasion Plus Minocycline Versus Apical Pleurectomy for Primary Spontaneous Pneumothorax Unknown status NCT00270751 Phase 2, Phase 3
27 Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax Unknown status NCT00154895 Phase 3 intrapleural minocycline instillation
28 Comparing 14 F Pigtail Catheter to Traditional 28-32F Chest Tube in the Management of Traumatic Hemothorax and Hemopneumothorax Unknown status NCT02553434 Phase 3
29 Intrapleural Urokinase for Retained Hemothorax Unknown status NCT01134237 Phase 3 urokinase;placebo
30 Systemic Chemotherapy Combined With Recombinant Human Adenovirus Type 5 and Endostatin Injections for Treatment Malignant Hydrothorax in NSCLC Patients Unknown status NCT02579564 Phase 3 Gemcitabine;Vinorelbine;Paclitaxel;Pemetrexed;Oncorine;Endostar;Cisplatin
31 COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial) Unknown status NCT01552187 Phase 3 Colchicine;Placebo
32 Dornase Alfa and Urokinase for Kids With Pleural Empyema Unknown status NCT00502632 Phase 2, Phase 3 Urokinase and Dornase alfa;Urokinase
33 Rigid Versus Semirigid Thoracoscopy in Diagnosing Pleural Diseases: a Randomized Study Completed NCT01366261 Phase 3
34 Cryobiopsy or Forceps Biopsy During Semirigid Thoracoscopy: a Comparative Study Completed NCT01475084 Phase 2, Phase 3
35 Indwelling Pleural Catheter for Trapped Lung Completed NCT03550027 Phase 3
36 Efficacy of the Additional Mechanical Pleurodesis for Surgical Management of Primary Spontaneous Pneumothorax Completed NCT00615849 Phase 3
37 Bio-Seal Biopsy Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Procedure Completed NCT00562302 Phase 3
38 Role of Antibiotics to Reduce Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax Completed NCT01127880 Phase 2, Phase 3 Ancef or Clindamycin;Placebo
39 Very Early Surfactant and NCPAP for Premature Infants With RDS Completed NCT00563641 Phase 3
40 Efficacy and Safety Study of Abnoba Viscum F 20mg in Malignant Pleural Effusion Patients Completed NCT02191540 Phase 3 Abnoba Viscum F 20mg
41 KatGuide Method Versus Conventional Method at Insertion of Chest Tube Completed NCT01522885 Phase 3
42 A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions Completed NCT00758316 Phase 3
43 Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial) Completed NCT01717742 Phase 3 tPA;DNase
44 Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small Cell Lung Cancer Completed NCT01661790 Phase 3 Bevacizumab;Cisplatin
45 Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions Completed NCT00002872 Phase 3 doxycycline
46 Talc in Treating Patients With Malignant Pleural Effusion Completed NCT00002622 Phase 3 talc;Talc
47 Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer Completed NCT00042770 Phase 3
48 Antibiotic Treatment of Gulf War Veterans' Illnesses Completed NCT00007735 Phase 3 Doxycycline (200mg/day) or Placebo
49 Effect of Dissecting of The Inferior Pulmonary Ligament on Postoperative Pulmonary Reexpansion and Recurrence Recruiting NCT02558608 Phase 3
50 Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion Recruiting NCT02674243 Phase 3 Iodopovidone solution;Talc

Search NIH Clinical Center for Pleural Disease

Cochrane evidence based reviews: pleural diseases

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Genetic Tests for Pleural Disease

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Genetic tests related to Pleural Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Pleura 29
Sources

Anatomical Context for Pleural Disease

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MalaCards organs/tissues related to Pleural Disease:

41
Lung, Heart, Brain, Kidney, Liver, Colon, Testis
Sources

Publications for Pleural Disease

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Articles related to Pleural Disease:

(show top 50) (show all 313)
# Title Authors Year
1
Year in review 2017: Interventional pulmonology, lung cancer, pleural disease and respiratory infections. ( 29641840 )
2018
2
Unexpandable lung from pleural disease. ( 29064169 )
2018
3
Pleural Disease. ( 29722518 )
2018
4
Pleural Disease. ( 29722519 )
2018
5
New insights in the use of pleural ultrasonography for diagnosis and treatment of pleural disease. ( 29679518 )
2018
6
Pleural Disease. ( 29466146 )
2018
7
Pleural Disease. ( 29719174 )
2018
8
Picking the winners: Outcome prediction in pleural disease. ( 29415343 )
2018
9
Outcomes of a Clinical Pathway for Pleural Disease Management: "Pleural Pathway". ( 29805807 )
2018
10
Relationships of Lower Lung Fibrosis, Pleural Disease, and Lung Mass with Occupational, Household, Neighborhood, and Slate Roof-Dense Area Residential Asbestos Exposure. ( 30072629 )
2018
11
Recent developments in pleurodesis for malignant pleural disease. ( 30252207 )
2018
12
Pleural manometry in patients with pleural diseases - the usefulness in clinical practice. ( 29402510 )
2018
13
Biomarkers in the diagnosis of pleural diseases: a 2018 update. ( 30354850 )
2018
14
Chest ultrasonography in health surveillance of asbestos related pleural disease. ( 28838385 )
2017
15
State-of-the-art: Radiological investigation of pleural disease. ( 28233652 )
2017
16
Medical Thoracoscopy in Pleural Disease: Experience from a One-Center Study. ( 28416960 )
2017
17
Ultrasound in the management of pleural disease. ( 28345480 )
2017
18
Safety and Performance Characteristics of Outpatient Medical Thoracoscopy and Indwelling Pleural Catheter Insertion for Evaluation and Diagnosis of Pleural Disease at a Tertiary Center in Canada. ( 28951662 )
2017
19
Primary Malignant Lymphoma Originating from the Chest Wall without Preceding Pleural Disease. ( 28321070 )
2017
20
Migrating pleural plaque in a patient with asbestos induced pleural disease: a case report. ( 28855951 )
2017
21
Management of occult malignant pleural disease firstly detected at thoracotomy for non-small cell lung cancer patients. ( 29268394 )
2017
22
The Effect of Benign and Malignant Pleural Disease on Chest Wall Mechanics. ( 28707974 )
2017
23
Tuberculous pleural effusion occurring concurrently with asbestos-related pleural disease. ( 28491491 )
2017
24
Lymphangioleiomyomatosis Diagnosis and Management: High-Resolution Chest Computed Tomography, Transbronchial Lung Biopsy, and Pleural Disease Management. An Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guideline. ( 29140122 )
2017
25
Year in review 2016: Respiratory infections, acute respiratory distress syndrome, pleural diseases, lung cancer and interventional pulmonology. ( 28244617 )
2017
26
Medical thoracoscopy and its evolving role in the diagnosis and treatment of pleural disease. ( 29214061 )
2017
27
Pleural Diseases: Saline Irrigation in Pleural Infection, Epidemiology of Pneumothorax, and Bevacizumab in Mesothelioma. ( 28598211 )
2017
28
Pleural diseases. ( 28257316 )
2017
29
A benchmarking project on the quality of previous guidelines about the management of malignant pleural effusion from the European Society of Thoracic Surgeons (ESTS) Pleural Diseases Working Group. ( 28402401 )
2017
30
Diagnostic approach to pleural diseases: new tricks for an old trade. ( 28781758 )
2017
31
VATS and open chest surgery in diagnosis and treatment of benign pleural diseases. ( 29078647 )
2017
32
Video assisted thoracoscopic and open chest surgery in diagnosis and treatment of malignant pleural diseases. ( 29078648 )
2017
33
IgG4-related disease in asbestos-related pleural disease. ( 26839697 )
2016
34
Ultrasound-Guided Abrams Pleural Biopsy vs CT-Guided Tru-Cut Pleural Biopsy in Malignant Pleural Disease, a 3-Year Follow-up Study. ( 27540734 )
2016
35
Rapid on-site evaluation with the Hemacolor rapid staining method of medical thoracoscopy biopsy specimens for the management of pleural disease. ( 27080382 )
2016
36
Erratum: Multidetector CT Findings and Differential Diagnoses of Malignant Pleural Mesothelioma and Metastatic Pleural Diseases in Korea. ( 27587973 )
2016
37
25-hydroxyvitamin D in malignant pleural disease: a prospective cohort study. ( 27502152 )
2016
38
Diagnostic Utility of Pleural Fluid Cell Block versus Pleural Biopsy Collected by Flex-Rigid Pleuroscopy for Malignant Pleural Disease: A Single Center Retrospective Analysis. ( 27880851 )
2016
39
Advances in pleural disease. ( 27246586 )
2016
40
Malignant pleural disease is highly associated with subsequent peritoneal metastasis in patients with stage IV non-small cell lung cancer independent of oncogene status. ( 27133746 )
2016
41
Reduced Port Thoracoscopic Surgery for Mediastinal and Pleural Disease: Experiences in a Single Institution. ( 27358509 )
2016
42
Should primary tumor be resected for non-small cell lung cancer with malignant pleural disease unexpectedly found during operation?-a systemic review and meta-analysis. ( 27867560 )
2016
43
Advanced medical interventions in pleural disease. ( 27246597 )
2016
44
Role of respiratory-triggered diffusion-weighted MRI in the assessment of pleural disease. ( 27302493 )
2016
45
"Advanced medical interventions in pleural disease." Rahul Bhatnagar, John P. Corcoran, Fabien Maldonado, David Feller-Kopman, Julius Janssen, Philippe Astoul and Najib M. Rahman. Eur Respir Rev 2016; 25: 199-213. ( 27581835 )
2016
46
Year in review 2015: Lung cancer, pleural diseases, respiratory infections, bronchiectasis and tuberculosis, bronchoscopic intervention and imaging. ( 26998678 )
2016
47
Multidetector CT Findings and Differential Diagnoses of Malignant Pleural Mesothelioma and Metastatic Pleural Diseases in Korea. ( 27390546 )
2016
48
The importance of units specialising in pleural disease for postgraduate training. ( 27908379 )
2016
49
Closing faucets: the role of anti-angiogenic therapies in malignant pleural diseases. ( 26680633 )
2016
50
Advances in pleural diseases: what is the future for medical thoracoscopy? ( 26989820 )
2016
Sources

Variations for Pleural Disease

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Sources

Expression for Pleural Disease

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Search GEO for disease gene expression data for Pleural Disease.
Sources

Pathways for Pleural Disease

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Pathways related to Pleural Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
mTOR signaling pathway (KEGG) 65
Show member pathways
 12.17 FLCN FNIP1 FNIP2 TNF
2
Selenium Micronutrient Network 1
Show member pathways
 11.89 ALB CRP IL1B TNF
3
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.35 CXCL13 IL1B TNF
4
Lung fibrosis 1
11.13 IL1B SPP1 TNF
5
G-protein signaling_Rap2B regulation pathway 22
10.67 CXCL13 EFEMP1 IL1B SPP1 TNF
6
LDL Oxidation in Atherogenesis 64
10.64 IL1B TNF
7
G-protein signaling_RhoB regulation pathway 22
10.49 CXCL13 IL1B TBP TNF
8
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.45 IL1B SPP1 TNF
Sources

GO Terms for Pleural Disease

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Cellular components related to Pleural Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ALB CHI3L1 CRP CXCL13 EFEMP1 IL1B
2 endoplasmic reticulum lumen GO:0005788 9.46 ALB KNG1 MSLN SPP1
3 extracellular space GO:0005615 9.36 ADA ALB CHI3L1 CRP CXCL13 EFEMP1

Biological processes related to Pleural Disease according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.93 CXCL13 EFEMP1 IL1B SPP1 TNF
2 cellular protein metabolic process GO:0044267 9.85 ALB KNG1 MSLN SPP1
3 positive regulation of protein phosphorylation GO:0001934 9.8 FLCN FNIP1 IL1B TNF
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.75 FNIP1 FNIP2 TNF
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IL1B TNF
6 TOR signaling GO:0031929 9.59 FLCN FNIP1
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
8 negative regulation of lipid storage GO:0010888 9.57 CRP TNF
9 TORC1 signaling GO:0038202 9.56 FNIP1 FNIP2
10 positive regulation of chemokine biosynthetic process GO:0045080 9.52 IL1B TNF
11 regulation of establishment of endothelial barrier GO:1903140 9.51 IL1B TNF
12 positive regulation of neuroinflammatory response GO:0150078 9.48 IL1B TNF
13 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
14 chronic inflammatory response to antigenic stimulus GO:0002439 9.43 IL1B TNF
15 sequestering of triglyceride GO:0030730 9.4 IL1B TNF
16 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IL1B TNF
17 positive regulation of protein complex assembly GO:0031334 9.33 FNIP1 FNIP2 TNF
18 positive regulation of estradiol secretion GO:2000866 9.32 IL1B SPP1
19 regulation of pro-B cell differentiation GO:2000973 9.26 FLCN FNIP1
20 regulation of protein phosphorylation GO:0001932 9.26 FLCN FNIP1 FNIP2 TNF
21 inflammatory response GO:0006954 9.17 CHI3L1 CRP CXCL13 IL1B KNG1 SPP1

Molecular functions related to Pleural Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 ADA ALB BAP1 CHI3L1 CRP DICER1
2 cytokine activity GO:0005125 9.46 CXCL13 IL1B SPP1 TNF
3 chaperone binding GO:0051087 9.43 ALB FNIP1 FNIP2
4 ATPase inhibitor activity GO:0042030 8.96 FNIP1 FNIP2
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Sources for Pleural Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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