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MCID: PLR022
MIFTS: 53

Pleural Disease

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pleural Disease

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MalaCards integrated aliases for Pleural Disease:

Name: Pleural Disease 12 15
Pleural Diseases 55 44 73
Non-Neoplastic Pleural Disorder 73
Non-Neoplastic Pleural Disease 12
Abnormality of the Pleura 29
Disorder of Pleura 12
Pleural Disorders 43

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1532
MeSH 44 D010995
NCIt 50 C26859
SNOMED-CT 68 88075009
ICD10 33 J94.9 Q34.0
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Summaries for Pleural Disease

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MedlinePlus : 43 Your pleura is a large, thin sheet of tissue that wraps around the outside of your lungs and lines the inside of your chest cavity. Between the layers of the pleura is a very thin space. Normally it's filled with a small amount of fluid. The fluid helps the two layers of the pleura glide smoothly past each other as your lungs breathe air in and out. Disorders of the pleura include Pleurisy - inflammation of the pleura that causes sharp pain with breathing Pleural effusion - excess fluid in the pleural space Pneumothorax - buildup of air or gas in the pleural space Hemothorax - buildup of blood in the pleural space Many different conditions can cause pleural problems. Viral infection is the most common cause of pleurisy. The most common cause of pleural effusion is congestive heart failure. Lung diseases, like COPD, tuberculosis, and acute lung injury, cause pneumothorax. Injury to the chest is the most common cause of hemothorax. Treatment focuses on removing fluid, air, or blood from the pleural space, relieving symptoms, and treating the underlying condition. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Pleural Disease, also known as pleural diseases, is related to pleurisy and pneumothorax, and has symptoms including apnea, pleuritic pain and coughing. An important gene associated with Pleural Disease is ADA (Adenosine Deaminase), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and Folate Metabolism. The drugs Histamine and Ketotifen have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes, and related phenotypes are homeostasis/metabolism and immune system

Disease Ontology : 12 A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism.

Wikipedia : 76 Pleural tumors may be benign (i.e. solitary fibromas) or malignant in nature. Pleural Mesothelioma is a... more...

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Related Diseases for Pleural Disease

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Diseases related to Pleural Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 pleurisy 31.6 ADA CRP MPO TNF
2 pneumothorax 30.4 FLCN FNIP1 FNIP2
3 peritonitis 28.1 ADA ALB CRP IL1B MPO TNF
4 chylothorax, congenital 10.8
5 systemic onset juvenile idiopathic arthritis 10.7 IL1B TNF
6 staphylococcal toxic shock syndrome 10.7 IL1B TNF
7 birt-hogg-dube syndrome 10.7 FLCN FNIP1 FNIP2
8 autoimmune myocarditis 10.7 IL1B TNF
9 gastrointestinal tuberculosis 10.6 ADA ALB
10 kashin-beck disease 10.6 IL1B TNF
11 pulpitis 10.6 IL1B KNG1 TNF
12 autoimmune inner ear disease 10.5 MPO TNF
13 kidney angiomyolipoma 10.5 FLCN FNIP1
14 streptococcal meningitis 10.5 ADA CRP TNF
15 cellulitis 10.5 CHI3L1 CRP TNF
16 brain edema 10.5 ALB IL1B KNG1
17 abdominal tuberculosis 10.5 ADA ALB CRP
18 burns 10.5 ALB IL1B TNF
19 renal hypertension 10.5 ALB KLKB1 KNG1
20 microscopic polyangiitis 10.4 MPO TNF
21 central nervous system vasculitis 10.4 CRP IL1B TNF
22 keratoconjunctivitis sicca 10.4 ALB IL1B TNF
23 sarcoidosis 1 10.4 ADA IL1B TNF
24 scrub typhus 10.4 CRP IL1B TNF
25 sleep apnea 10.4 CHI3L1 CRP TNF
26 spondylitis 10.4 CHI3L1 CRP TNF
27 adult-onset still's disease 10.4 CRP IL1B TNF
28 perinatal necrotizing enterocolitis 10.4 CRP IL1B TNF
29 palindromic rheumatism 10.4 CRP IL1B TNF
30 cystitis 10.4 CRP KNG1 TNF
31 uterine anomalies 10.4 CRP IL1B TNF
32 pleural empyema 10.4 ADA CRP CTSC
33 leptospirosis 10.4 CRP IL1B TNF
34 hypersensitivity reaction disease 10.4 ALB IL1B TNF
35 chorioamnionitis 10.4 CRP IL1B TNF
36 lyme disease 10.4 CRP IL1B TNF
37 pulmonary edema 10.4 CRP IL1B TNF
38 vulvar vestibulitis syndrome 10.3 IL1B TNF
39 familial mediterranean fever 10.3 CRP IL1B TNF
40 chlamydia 10.3 CRP IL1B TNF
41 bone inflammation disease 10.3 CRP IL1B TNF
42 otitis media 10.3 ALB IL1B TNF
43 aggressive periodontitis 10.3 CTSC IL1B TNF
44 juvenile rheumatoid arthritis 10.3 CRP IL1B TNF
45 acquired immunodeficiency syndrome 10.3 ALB IL1B TNF
46 mouth disease 10.3 CRP IL1B TNF
47 trypanosomiasis 10.3 ALB IL1B TNF
48 hemorrhagic fever with renal syndrome 10.3 ALB CRP TNF
49 hydrops, lactic acidosis, and sideroblastic anemia 10.3 ALB KNG1 MPO
50 rheumatic disease 10.3 CRP IL1B TNF

Graphical network of the top 20 diseases related to Pleural Disease:



Diseases related to Pleural Disease
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Symptoms & Phenotypes for Pleural Disease

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UMLS symptoms related to Pleural Disease:


apnea, pleuritic pain, coughing, dyspnea, snoring

MGI Mouse Phenotypes related to Pleural Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 IL1B KLKB1 MPO REG1A SLC22A4 TNF
2 immune system MP:0005387 9.7 IL1B MPO SLC22A4 TNF ADA CHI3L1
3 neoplasm MP:0002006 9.1 FNIP2 IL1B TNF ALB FLCN FNIP1
Sources

Drugs & Therapeutics for Pleural Disease

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Drugs for Pleural Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 269)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4,Phase 2,Not Applicable 75614-87-8, 51-45-6 774
2
Ketotifen Approved Phase 4 34580-14-8, 34580-13-7 3827
3
Azithromycin Approved Phase 4,Not Applicable 83905-01-5 55185 447043
4
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 564-25-0 54671203
5
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
6
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
7
Cefazolin Approved Phase 4,Phase 2,Phase 3 25953-19-9 656510 33255
8
Clindamycin Approved, Vet_approved Phase 4,Phase 2,Phase 3 18323-44-9 29029
9
Zoledronic acid Approved Phase 4,Phase 2 118072-93-8 68740
10
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
12
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
13
Ofloxacin Approved Phase 4 82419-36-1 4583
14
Iodine Approved, Investigational Phase 4,Phase 3,Not Applicable 7553-56-2 807
15
Povidone Approved Phase 4,Phase 3 9003-39-8
16
Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
17
Mesna Approved, Investigational Phase 4 3375-50-6 598
18
Streptokinase Approved, Investigational Phase 4 9002-01-1
19 Anti-Allergic Agents Phase 4
20 Antipruritics Phase 4
21 Dermatologic Agents Phase 4,Phase 1
22 Histamine Antagonists Phase 4,Phase 2,Not Applicable
23 Histamine H1 Antagonists Phase 4
24
Histamine Phosphate Phase 4,Phase 2,Not Applicable 51-74-1 65513
25 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
26 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
27 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Not Applicable
28 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Antitubercular Agents Phase 4,Phase 2,Phase 3,Not Applicable
30 Antimalarials Phase 4,Phase 3,Phase 2,Not Applicable
31 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
32 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
33 Pulmonary Surfactants Phase 4,Phase 3
34 Respiratory System Agents Phase 4,Phase 3
35 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Plasminogen Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Bone Density Conservation Agents Phase 4,Phase 2
39 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable
40 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
41 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
42 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2
43 Clindamycin palmitate Phase 4,Phase 2,Phase 3
44 Clindamycin phosphate Phase 4,Phase 2,Phase 3
45 Diphosphonates Phase 4,Phase 2
46 Antiemetics Phase 4,Phase 2,Phase 1,Not Applicable
47 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Not Applicable
48 Autonomic Agents Phase 4,Phase 2,Not Applicable
49 Gastrointestinal Agents Phase 4,Phase 2,Not Applicable
50 glucocorticoids Phase 4,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 329)
# Name Status NCT ID Phase Drugs
1 Improving Primary Spontaneous Pneumothorax (PSP) Treatment Techniques in VATS Unknown status NCT01463553 Phase 4
2 The Effect of Chest Tubes Using Active Clearance Technology® on the Incidence of Postoperative Atrial Fibrillation Unknown status NCT02808897 Phase 4
3 Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Unknown status NCT02673840 Phase 4 Ketotifen;Placebo
4 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
5 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
6 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
7 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
8 Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema Completed NCT01246453 Phase 4 Intrapleurally Alteplase vs Intrapleurally Urokinase
9 Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy Completed NCT02446782 Phase 4 Cefazolin
10 Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion Completed NCT01670786 Phase 4
11 Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter Completed NCT00978939 Phase 4
12 Talc Pleurodesis in Patients With Recurrent Malignant Pleural Effusion Completed NCT00789087 Phase 4
13 Non-small Cell Lung Cancer Registry Completed NCT00099541 Phase 4 zoledronic acid
14 Fibrinolytic Therapy Versus Medical Thoracoscopy Recruiting NCT03213834 Phase 4 tPA;DNase
15 Fibrinolysis Compared to Thoracoscopy for Pleural Infection Recruiting NCT03468933 Phase 4 tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase)
16 Early Intrapleural TPA Instillation Versus Late Recruiting NCT03167281 Phase 4
17 Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia Recruiting NCT02618057 Phase 4 Prednisolone;Levofloxacin
18 Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital Not yet recruiting NCT03172052 Phase 4 streptokinase;MESNA (2-mercaptoethane sulfonate Na)
19 Betadine Pleurodesis Via Tunneled Pleural Catheters Not yet recruiting NCT02975921 Phase 4 Povidone-Iodine
20 Safety, Efficacy, and Side Effects Study of Interventional Cryotherapy in the Pleural Space("ICE PLS") Terminated NCT00747916 Phase 4
21 Pigtail Catheter Versus Chest Tube in the Management of Traumatic Pneumothorax Unknown status NCT01537289 Phase 3
22 Chest Tube Drainage or Thoracoscopic Surgery for Failed Aspiration of Spontaneous Pneumothorax Unknown status NCT00713362 Phase 2, Phase 3
23 Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax Unknown status NCT00418392 Phase 3
24 Pleural Abrasion Plus Minocycline Versus Apical Pleurectomy for Primary Spontaneous Pneumothorax Unknown status NCT00270751 Phase 2, Phase 3
25 Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax Unknown status NCT00154895 Phase 3 intrapleural minocycline instillation
26 Comparing 14 F Pigtail Catheter to Traditional 28-32F Chest Tube in the Management of Traumatic Hemothorax and Hemopneumothorax Unknown status NCT02553434 Phase 3
27 Intrapleural Urokinase for Retained Hemothorax Unknown status NCT01134237 Phase 3 urokinase;placebo
28 COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial) Unknown status NCT01552187 Phase 3 Colchicine;Placebo
29 Dornase Alfa and Urokinase for Kids With Pleural Empyema Unknown status NCT00502632 Phase 2, Phase 3 Urokinase and Dornase alfa;Urokinase
30 Rigid Versus Semirigid Thoracoscopy in Diagnosing Pleural Diseases: a Randomized Study Completed NCT01366261 Phase 3
31 Cryobiopsy or Forceps Biopsy During Semirigid Thoracoscopy: a Comparative Study Completed NCT01475084 Phase 2, Phase 3
32 Indwelling Pleural Catheter for Trapped Lung Completed NCT03550027 Phase 3
33 Efficacy of the Additional Mechanical Pleurodesis for Surgical Management of Primary Spontaneous Pneumothorax Completed NCT00615849 Phase 3
34 Bio-Seal Biopsy Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Procedure Completed NCT00562302 Phase 3
35 Role of Antibiotics to Reduce Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax Completed NCT01127880 Phase 2, Phase 3 Ancef or Clindamycin;Placebo
36 Very Early Surfactant and NCPAP for Premature Infants With RDS Completed NCT00563641 Phase 3
37 Efficacy and Safety Study of Abnoba Viscum F 20mg in Malignant Pleural Effusion Patients Completed NCT02191540 Phase 3 Abnoba Viscum F 20mg
38 KatGuide Method Versus Conventional Method at Insertion of Chest Tube Completed NCT01522885 Phase 3
39 A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions Completed NCT00758316 Phase 3
40 Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial) Completed NCT01717742 Phase 3 tPA;DNase
41 Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small Cell Lung Cancer Completed NCT01661790 Phase 3 Bevacizumab;Cisplatin
42 Bleomycin, Doxycycline, or Talc in Treating Patients With Malignant Pleural Effusions Completed NCT00002872 Phase 3 doxycycline
43 Talc in Treating Patients With Malignant Pleural Effusion Completed NCT00002622 Phase 3 talc;Talc
44 Standard Chest Tube Compared With a Small Catheter in Treating Malignant Pleural Effusion in Patients With Cancer Completed NCT00042770 Phase 3
45 Antibiotic Treatment of Gulf War Veterans' Illnesses Completed NCT00007735 Phase 3 Doxycycline (200mg/day) or Placebo
46 Absorbable Mesh Pleurodesis in Thoracoscopic Treatment of Spontaneous Pneumothorax Recruiting NCT01848860 Phase 2, Phase 3
47 Effect of Dissecting of The Inferior Pulmonary Ligament on Postoperative Pulmonary Reexpansion and Recurrence Recruiting NCT02558608 Phase 3
48 Efficacy of Iodopovidone Versus Talc in Palliative Malignant Pleural Effusion Recruiting NCT02674243 Phase 3 Iodopovidone solution;Talc
49 A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion Recruiting NCT02583282 Phase 3
50 Comparison of Intrapleural Urokinase and Video-Assisted Thorascopic Surgery in the Treatment of Parapneumonic Pleural Effusion in Children Recruiting NCT02165891 Phase 3 insertion of a chest drain with urokinase instillation

Search NIH Clinical Center for Pleural Disease

Cochrane evidence based reviews: pleural diseases

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Genetic Tests for Pleural Disease

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Genetic tests related to Pleural Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Pleura 29
Sources

Anatomical Context for Pleural Disease

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MalaCards organs/tissues related to Pleural Disease:

41
Lung, Heart, Testes, T Cells, Myeloid, Endothelial, Bone
Sources

Publications for Pleural Disease

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Articles related to Pleural Disease:

(show top 50) (show all 70)
# Title Authors Year
1
Year in review 2017: Interventional pulmonology, lung cancer, pleural disease and respiratory infections. ( 29641840 )
2018
2
Unexpandable lung from pleural disease. ( 29064169 )
2018
3
Pleural Disease. ( 29722518 )
2018
4
Pleural Disease. ( 29722519 )
2018
5
New insights in the use of pleural ultrasonography for diagnosis and treatment of pleural disease. ( 29679518 )
2018
6
Pleural Disease. ( 29466146 )
2018
7
Pleural Disease. ( 29719174 )
2018
8
Picking the winners: Outcome prediction in pleural disease. ( 29415343 )
2018
9
Outcomes of a Clinical Pathway for Pleural Disease Management: "Pleural Pathway". ( 29805807 )
2018
10
Chest ultrasonography in health surveillance of asbestos related pleural disease. ( 28838385 )
2017
11
State-of-the-art: Radiological investigation of pleural disease. ( 28233652 )
2017
12
Medical Thoracoscopy in Pleural Disease: Experience from a One-Center Study. ( 28416960 )
2017
13
Ultrasound in the management of pleural disease. ( 28345480 )
2017
14
Safety and Performance Characteristics of Outpatient Medical Thoracoscopy and Indwelling Pleural Catheter Insertion for Evaluation and Diagnosis of Pleural Disease at a Tertiary Center in Canada. ( 28951662 )
2017
15
Primary Malignant Lymphoma Originating from the Chest Wall without Preceding Pleural Disease. ( 28321070 )
2017
16
Migrating pleural plaque in a patient with asbestos induced pleural disease: a case report. ( 28855951 )
2017
17
Management of occult malignant pleural disease firstly detected at thoracotomy for non-small cell lung cancer patients. ( 29268394 )
2017
18
The Effect of Benign and Malignant Pleural Disease on Chest Wall Mechanics. ( 28707974 )
2017
19
Tuberculous pleural effusion occurring concurrently with asbestos-related pleural disease. ( 28491491 )
2017
20
Lymphangioleiomyomatosis Diagnosis and Management: High-Resolution Chest Computed Tomography, Transbronchial Lung Biopsy, and Pleural Disease Management. An Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guideline. ( 29140122 )
2017
21
Medical thoracoscopy and its evolving role in the diagnosis and treatment of pleural disease. ( 29214061 )
2017
22
IgG4-related disease in asbestos-related pleural disease. ( 26839697 )
2016
23
Ultrasound-Guided Abrams Pleural Biopsy vs CT-Guided Tru-Cut Pleural Biopsy in Malignant Pleural Disease, a 3-Year Follow-up Study. ( 27540734 )
2016
24
Rapid on-site evaluation with the Hemacolor rapid staining method of medical thoracoscopy biopsy specimens for the management of pleural disease. ( 27080382 )
2016
25
Erratum: Multidetector CT Findings and Differential Diagnoses of Malignant Pleural Mesothelioma and Metastatic Pleural Diseases in Korea. ( 27587973 )
2016
26
25-hydroxyvitamin D in malignant pleural disease: a prospective cohort study. ( 27502152 )
2016
27
Diagnostic Utility of Pleural Fluid Cell Block versus Pleural Biopsy Collected by Flex-Rigid Pleuroscopy for Malignant Pleural Disease: A Single Center Retrospective Analysis. ( 27880851 )
2016
28
Advances in pleural disease. ( 27246586 )
2016
29
Malignant pleural disease is highly associated with subsequent peritoneal metastasis in patients with stage IV non-small cell lung cancer independent of oncogene status. ( 27133746 )
2016
30
Reduced Port Thoracoscopic Surgery for Mediastinal and Pleural Disease: Experiences in a Single Institution. ( 27358509 )
2016
31
Should primary tumor be resected for non-small cell lung cancer with malignant pleural disease unexpectedly found during operation?-a systemic review and meta-analysis. ( 27867560 )
2016
32
Advanced medical interventions in pleural disease. ( 27246597 )
2016
33
Role of respiratory-triggered diffusion-weighted MRI in the assessment of pleural disease. ( 27302493 )
2016
34
"Advanced medical interventions in pleural disease." Rahul Bhatnagar, John P. Corcoran, Fabien Maldonado, David Feller-Kopman, Julius Janssen, Philippe Astoul and Najib M. Rahman. Eur Respir Rev 2016; 25: 199-213. ( 27581835 )
2016
35
The importance of units specialising in pleural disease for postgraduate training. ( 27908379 )
2016
36
A modified experimental model of malignant pleural disease induced by lung Lewis carcinoma (LLC) cells. ( 26373420 )
2015
37
Physical activity in people with asbestos related pleural disease and dust-related interstitial lung disease: An observational study. ( 26048393 )
2015
38
A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: a proof of principle pilot study. ( 25781025 )
2015
39
The past, current and future of diagnosis and management of pleural disease. ( 26807281 )
2015
40
Accidental discovery of asbestos-related occupational pleural disease in unemployed carpenter: a healthcare safety net that needs mending. ( 26444343 )
2015
41
The impact of pleural disease on the management of advanced ovarian cancer. ( 25969350 )
2015
42
Mediastinectomy for management of chronic pyogranulomatous pleural disease in dogs. ( 24686857 )
2014
43
Autofluorescence thoracoscopy in pleural disease: does it have clinical relevance? ( 24856077 )
2014
44
IgG4-related pleural disease presenting as a massive bilateral effusion. ( 24992134 )
2014
45
Advances in pleural disease management including updated procedural coding. ( 25091756 )
2014
46
Rapid progression of pleural disease due to exposure to Libby amphibole: "Not your grandfather's asbestos related disease". ( 24898907 )
2014
47
Physician-based ultrasound-guided biopsy for diagnosing pleural disease. ( 24832701 )
2014
48
A rare cause of pleural disease. ( 23487832 )
2013
49
Advances in the management of pleural disease. ( 24138694 )
2013
50
Progress means change: reflections on two articles about pleural disease. ( 23720696 )
2013
Sources

Variations for Pleural Disease

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Sources

Expression for Pleural Disease

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Search GEO for disease gene expression data for Pleural Disease.
Sources

Pathways for Pleural Disease

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Pathways related to Pleural Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
mTOR signaling pathway (KEGG) 65
Show member pathways
 12.09 FLCN FNIP1 FNIP2 TNF
2
Folate Metabolism 1
Show member pathways
 11.69 ALB CRP IL1B MPO TNF
3
amb2 Integrin signaling 1
11.11 KNG1 MPO TNF
4
MSP-RON Signaling 64
11.01 IL1B KLKB1 TNF
5
LDL Oxidation in Atherogenesis 64
10 IL1B MPO TNF
Sources

GO Terms for Pleural Disease

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Cellular components related to Pleural Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.96 ALB CHI3L1 CRP CTSC IL1B KLKB1
2 extracellular region GO:0005576 9.65 ALB CHI3L1 CRP CTSC CXCL13 IL1B
3 lysosome GO:0005764 9.55 ADA CTSC FLCN IL1B MPO
4 extracellular space GO:0005615 9.4 ADA ALB CHI3L1 CRP CTSC CXCL13

Biological processes related to Pleural Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.73 FLCN FNIP1 IL1B TNF
2 defense response GO:0006952 9.71 CXCL13 MPO REG1A TNF
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.7 FNIP1 FNIP2 TNF
4 negative regulation of lipid catabolic process GO:0050995 9.58 IL1B TNF
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 IL1B TNF
6 TOR signaling GO:0031929 9.56 FLCN FNIP1
7 negative regulation of growth of symbiont in host GO:0044130 9.55 MPO TNF
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 IL1B TNF
9 negative regulation of lipid storage GO:0010888 9.51 CRP TNF
10 positive regulation of chemokine biosynthetic process GO:0045080 9.49 IL1B TNF
11 regulation of establishment of endothelial barrier GO:1903140 9.48 IL1B TNF
12 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
13 sequestering of triglyceride GO:0030730 9.37 IL1B TNF
14 positive regulation of protein complex assembly GO:0031334 9.33 FNIP1 FNIP2 TNF
15 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IL1B TNF
16 regulation of pro-B cell differentiation GO:2000973 9.26 FLCN FNIP1
17 regulation of protein phosphorylation GO:0001932 9.26 FLCN FNIP1 FNIP2 TNF
18 inflammatory response GO:0006954 9.17 CHI3L1 CRP CXCL13 IL1B KLKB1 KNG1

Molecular functions related to Pleural Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase inhibitor activity GO:0042030 8.96 FNIP1 FNIP2
2 chaperone binding GO:0051087 8.92 ALB CTSC FNIP1 FNIP2
Sources

Sources for Pleural Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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