Aliases & Classifications for Pleural Disease

MalaCards integrated aliases for Pleural Disease:

Name: Pleural Disease 12 15
Pleural Diseases 54 43 71
Non-Neoplastic Pleural Disorder 71
Non-Neoplastic Pleural Disease 12
Abnormality of the Pleura 29
Disorder of Pleura 12
Pleural Disorders 42


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Disease Ontology 12 DOID:1532
MeSH 43 D010995
NCIt 49 C26859
SNOMED-CT 67 88075009
ICD10 32 Q34.0
UMLS 71 C0032226 C1335034

Summaries for Pleural Disease

MedlinePlus : 42 Your pleura is a large, thin sheet of tissue that wraps around the outside of your lungs and lines the inside of your chest cavity. Between the layers of the pleura is a very thin space. Normally it's filled with a small amount of fluid. The fluid helps the two layers of the pleura glide smoothly past each other as your lungs breathe air in and out. Disorders of the pleura include Pleurisy - inflammation of the pleura that causes sharp pain with breathing Pleural effusion - excess fluid in the pleural space Pneumothorax - buildup of air or gas in the pleural space Hemothorax - buildup of blood in the pleural space Many different conditions can cause pleural problems. Viral infection is the most common cause of pleurisy. The most common cause of pleural effusion is congestive heart failure. Lung diseases, like COPD, tuberculosis, and acute lung injury, cause pneumothorax. Injury to the chest is the most common cause of hemothorax. Treatment focuses on removing fluid, air, or blood from the pleural space, relieving symptoms, and treating the underlying condition. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Pleural Disease, also known as pleural diseases, is related to pneumothorax and malignant pleural mesothelioma, and has symptoms including dyspnea, apnea and snoring. An important gene associated with Pleural Disease is ADA (Adenosine Deaminase), and among its related pathways/superpathways are MicroRNAs in cancer and Metastatic brain tumor. The drugs Mesna and Streptokinase have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and breast.

Disease Ontology : 12 A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism.

Wikipedia : 74 Plural disease occurs in the pleural space, which is the thin fluid-filled area in between the two... more...

Related Diseases for Pleural Disease

Diseases related to Pleural Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 pneumothorax 31.4 SLC22A4 FLCN CALB2
2 malignant pleural mesothelioma 31.2 MSLN MIR625 MIR223 CALB2
3 pleural empyema 30.9 CRP ADA
4 endometriosis 30.3 MIR29C MIR223 MIR125A CALB2
5 constrictive pericarditis 30.3 CRP CALB2 ADA
6 lung cancer susceptibility 3 30.0 MSLN MIRLET7A1 MIR625 MIR32 MIR29C MIR138-1
7 pleural cancer 29.8 MSLN MIRLET7B MIRLET7A1 MIR625 MIR32 MIR29C
8 lung cancer 29.7 MSLN MIRLET7B MIRLET7A1 MIR708 MIR625 MIR32
9 ovarian cancer 29.5 MSLN MIRLET7B MIRLET7A1 MIR29C MIR223 MIR125B1
10 pleurisy 11.4
11 chylothorax, congenital 11.1
12 liver fibroma 10.6 MSLN CALB2
13 tuberculous peritonitis 10.6 CRP ADA
14 gynandroblastoma 10.6 DICER1 CALB2
15 tertiary syphilis 10.6 CXCL13 CRP
16 pericardium cancer 10.6 MSLN MIR32 CALB2
17 pericardial mesothelioma 10.6 MIR32 CALB2
18 malignant biphasic mesothelioma 10.6 MSLN CALB2
19 gastrointestinal tuberculosis 10.6 CRP ADA
20 cystic nephroma 10.6 MIRLET7A1 MIR138-1 DICER1
21 pericardial tuberculosis 10.6 CRP CALB2 ADA
22 cardiac tamponade 10.6 CRP CALB2 ADA
23 infected hydrocele 10.6 CRP CALB2
24 pericardium disease 10.6 CRP CALB2 ADA
25 laryngeal disease 10.6 MIRLET7B MIRLET7A1 H2AC18
26 epiglottitis 10.6 SLC22A4 CRP
27 tracheitis 10.5 SLC22A4 CRP
28 bacterial pneumonia 10.5 H2AC18 CRP ADA
29 ovarian serous carcinoma 10.5 MIRLET7B MIR125A CALB2
30 extrinsic cardiomyopathy 10.5 MIR223 H2AC18 CRP
31 infratentorial cancer 10.5 MIR125B1 MIR125A H2AC18
32 juvenile type testicular granulosa cell tumor 10.5 DICER1 CALB2
33 aspiration pneumonitis 10.5 SLC22A4 CRP
34 intestinal benign neoplasm 10.5 MIR625 MIR124-1 H2AC18
35 testicular granulosa cell tumor 10.5 DICER1 CALB2
36 collagen disease 10.5 MIR223 H2AC18 CRP
37 rectum cancer 10.5 MIRLET7B MIRLET7A1 MIR625 MIR125A
38 benign peritoneal mesothelioma 10.5 MSLN CALB2
39 abdominal tuberculosis 10.5 CRP ADA
40 tuberculous epididymitis 10.5 CRP CALB2
41 testicular disease 10.5 H2AC18 DICER1 CALB2
42 benign mesothelioma 10.5
43 ovary adenocarcinoma 10.5 MSLN MIR29C H2AC18 CALB2
44 thyroid gland disease 10.5 MIR32 MIR138-1 MIR125A H2AC18
45 malignant ovarian surface epithelial-stromal neoplasm 10.5 MSLN MIR29C MIR125A H2AC18
46 ovary epithelial cancer 10.5 MSLN MIR29C MIR125A H2AC18
47 lymphatic system disease 10.5 MIR125A H2AC18 CRP
48 ovarian sex-cord stromal tumor 10.5 DICER1 CALB2
49 endemic typhus 10.5 H2AC18 CRP
50 mycobacterium tuberculosis 1 10.5 MIR223 H2AC18 CRP ADA

Graphical network of the top 20 diseases related to Pleural Disease:

Diseases related to Pleural Disease

Symptoms & Phenotypes for Pleural Disease

UMLS symptoms related to Pleural Disease:

dyspnea, apnea, snoring, coughing, pleuritic pain

Drugs & Therapeutics for Pleural Disease

Drugs for Pleural Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 103)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Mesna Approved, Investigational Phase 4 3375-50-6 598
Streptokinase Approved, Investigational Phase 4 9002-01-1
3 Plasminogen Phase 4
4 Tissue Plasminogen Activator Phase 4
5 Protective Agents Phase 4
6 Fibrinolytic Agents Phase 4
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
Nitrous oxide Approved, Vet_approved Phase 2, Phase 3 10024-97-2 948
9 Anti-Bacterial Agents Phase 3
10 Anti-Infective Agents Phase 3
Trioxsalen Approved Phase 2 3902-71-4 5585
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
18 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
19 Artichoke Approved Phase 2
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
21 Ether Phase 2
22 Dermatologic Agents Phase 2
23 Photosensitizing Agents Phase 2
24 Dihematoporphyrin Ether Phase 2
25 Antiemetics Phase 2
26 Autonomic Agents Phase 2
27 Hydrocortisone hemisuccinate Phase 2
28 Methylprednisolone Acetate Phase 2
29 Hydrocortisone 17-butyrate 21-propionate Phase 2
30 Gastrointestinal Agents Phase 2
31 Hormone Antagonists Phase 2
32 Neuroprotective Agents Phase 2
33 Anti-Inflammatory Agents Phase 2
34 Antineoplastic Agents, Hormonal Phase 2
35 glucocorticoids Phase 2
36 Hormones Phase 2
Dasatinib Approved, Investigational Phase 1 302962-49-8 3062316
afatinib Approved Phase 1 850140-72-6, 439081-18-2 10184653
Acetaminophen Approved Phase 1 103-90-2 1983
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
Diphenhydramine Approved, Investigational Phase 1 147-24-0, 58-73-1 3100
Pembrolizumab Approved Phase 1 1374853-91-4
Promethazine Approved, Investigational Phase 1 60-87-7 4927
Tyrosine Approved, Investigational, Nutraceutical Phase 1 60-18-4 6057
45 Vaccines Phase 1
46 Protein Kinase Inhibitors Phase 1
47 Mitogens Phase 1
48 Alkylating Agents Phase 1
49 Antineoplastic Agents, Immunological Phase 1
50 Antirheumatic Agents Phase 1

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double Blind, Controlled Trial to Evaluate Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Pleural Empyema Completed NCT01246453 Phase 4 Intrapleurally Alteplase vs Intrapleurally Urokinase
2 Intrapleural Tissue Plasminogen Activator and Deoxyribonuclease Therapy Versus Early Medical Thoracoscopy for Treatment of Pleural Infection: A Randomized Clinical Trial Recruiting NCT03468933 Phase 4 tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase)
3 Early Intrapleural TPA Instillation Versus Late Recruiting NCT03167281 Phase 4
4 Fibrinolytic Therapy Versus Medical Thoracoscopy for Treatment of Severe Pleural Infection: A Randomized Clinical Trial Recruiting NCT03213834 Phase 4 tPA;DNase
5 Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital Not yet recruiting NCT03172052 Phase 4 streptokinase;MESNA (2-mercaptoethane sulfonate Na)
6 Comparison of Chest Tube Drainage Versus Thoracoscopic Surgery for Unsuccessful Aspiration of Primary Spontaneous Pneumothorax: a Prospective Randomized Trial Unknown status NCT00713362 Phase 2, Phase 3
7 Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax: A Randomized Trial Unknown status NCT00418392 Phase 3
8 Rigid Versus Semirigid Thoracoscopy in Diagnosing Pleural Diseases: a Randomized Study Completed NCT01366261 Phase 3
9 Cryobiopsy or Forceps Biopsy During Semirigid Thoracoscopy: a Comparative Study Completed NCT01475084 Phase 2, Phase 3
10 A Randomized Controlled Study of Early Mini-invasive Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusions or Pleural Empyema - ESMITE (European Study on Mini-invasive Thoracoscopy in Empyema) Terminated NCT00234208 Phase 3
11 Retrospective Study of Intrapleural Methylprednisolone Injection for Multiple Organ Failure With Acute Respiratory Distress Syndrome Completed NCT01423864 Phase 2 conventional ECMO with intravenous steroid;solumedrol
12 A Phase II Study of Pleural Photodynamic Therapy for Patients With Non-small Cell Lung Cancer and Pleural Spread Completed NCT00601848 Phase 2 chemotherapy;porfimer sodium
13 Tomotherapy Treatment for Mesothelioma Completed NCT00469196 Phase 2
14 Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed Population (The ABOCA Phase II Trial) Recruiting NCT02076672 Phase 2 Artichoke WPC
15 A Phase I Study on Dendritic Cells Loaded With Allogeneous Cell Lysate in Patients With Mesothelioma as Maintenance Treatment After Chemotherapy Unknown status NCT02395679 Phase 1
16 Phase I Trial Evaluating Safety and Tolerability of the Irreversible Epidermal Growth Factor Receptor Inhibitor Afatinib (BIBW 2992) in Combination With the SRC Kinase Inhibitor Dasatinib for Patients With Non-small Cell Lung Cancer (NSCLC) Completed NCT01999985 Phase 1 Dasatinib - 1A;Afatinib - 1A;Dasatinib - 1B;Afatinib - 1B
17 A Phase I Clinical Trial of Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin Recruiting NCT02414269 Phase 1 cyclophosphamide;pembrolizumab
18 Light Dosimetry for Intraoperative Photodynamic Therapy (IO-PDT) With Porfimer Sodium (Photofrin?) in Patients With Malignant Mesothelioma or Non-Small Cell Lung Cancer (NSCLC) With Pleural Disease - Phase I Study Not yet recruiting NCT03678350 Phase 1 Porfimer Sodium
19 Cervical Video Assisted Thoracoscopic Surgery (C-VATS)Using a Flexible Endoscope for Thoracoscopy Unknown status NCT01440244
20 Can High Frequency Transthoracic Sonography Play a Competition Role With High Resolution Computed Tomography in Assessment of Alveolar Intersitial Syndrome Unknown status NCT03172585
21 Randomized Study Comparing Pleural Drainage by Videothoracoscopy to Medical Drainage in Infectious Pleural Effusion Unknown status NCT01994499 Medical drainage
22 Liquid Biopsy With Immunomagnetic Beads Capture Technique for Malignant Cell Detection in Body Fluid Unknown status NCT02891642
23 Confocal Laser Endomicroscopy in Pleural Malignancies: A Comparison With Pathology Unknown status NCT03290183
24 Relationship Between Pleural Elastance and Effectiveness of Pleurodesis on Recurrent Malignant Pleural Effusion Unknown status NCT01819363
25 Ultrasound Estimation of Pleural Effusion in the Sitting Patients Unknown status NCT02809872
26 How Should be Invasive Diagnostic Algorithm in Pleural Diseases Completed NCT03153501
27 Outcome of Patients Who Could Not Have Been Diagnosed by Medical Thoracoscopy Completed NCT01356979
28 Safety of Thoracoscopy in Patients With High Risk Completed NCT01193439
30 Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy For Diagnosis of Patients With Pleural Effusions: A Randomized Control Trial Completed NCT00720954
32 Pleural Cryobiopsies During Semirigid Thoracoscopy: A New Technique Completed NCT01472172 Early Phase 1
33 Vacuum vs Manual Drainage During Unilateral Thoracentesis: A Randomized Trial Completed NCT03496987
34 Nuclear Matrix and Cancer: Proteomic and Genomic Analyses Using Microarray in Cells Obtained Via Thoracocentesis Completed NCT01284777
35 Analysis of Time-motion-mode Ultrasound Diaphragm Measures in Patients With Acute Respiratory Distress in Emergency Department: Predicting Respiratory Prognosis Completed NCT02273687
36 Impact of Respiratory Physiotherapy in the Management of Infectious Pleural Effusion Recruiting NCT02359383
37 Pleural Disease: Phenotypes, Diagnostic Yield and Outcomes Recruiting NCT03922841
38 A Prospective Observational Study Examining the Clinical Utility of Novel Pleural Fluid, Biopsy and Serum Bio Markers for the Investigation of Pleural Effusions Recruiting NCT03661801
39 To Study the Safety and Efficacy of Midodrine With Albumin Versus Albumin Alone in Hepatic Hydrothorax- A Pilot Randomised Controlled Trial Recruiting NCT03645642 Midodrine;Diuretics
40 Fibrinolytic Therapy Versus Medical Thoracoscopy for Treatment of Pleural Infection: A Randomized Clinical Trial Recruiting NCT02973139
41 Talc Outpatient Pleurodesis With Indwelling Catheter: A Randomized Controlled Trial Recruiting NCT03973957 Fentanyl Citrate;Talc Slurry
42 Multicenter, International Online Documentation of Indications and Results of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC Und PITAC) for Treating Malignant Peritoneal and Pleural Diseases Recruiting NCT03210298
43 Lung Ultrasound Characterization of Bullous Emphysema Recruiting NCT04012359
44 Thoracoscopic Treatment of Primary Pneumothorax - A National Randomised Controlled Trial Recruiting NCT02866305 Early Phase 1 Epidural
45 The Impact of a Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System on Pain: A Multicenter, Randomized Trial Recruiting NCT03831386
46 Impact of Gated PET/CT on the Diagnosis of Distant Metastases of Advanced Epithelial Ovarian, Fallopian Tube, and Primary Peritoneal Cancer Recruiting NCT02258165
47 The Effect on Respiratory Function of Monitored Anesthesia Care With Dexmedetomidine in Patients Undergoing Diagnostic or Therapeutic Pleuroscopy Recruiting NCT03597828
48 The Diagnosis and Mechanism of Pleural Effusion Active, not recruiting NCT03997669
49 Role of Chest Sonography in Evaluation of Successful Pleurodesis in Patients With Malignant Pleural Effusion Not yet recruiting NCT04074902
50 Suturing With U-Technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy-tube Drain - A Single-centre Open-label Randomized Prospective Trial (SUTURE TRIAL) Not yet recruiting NCT04193241

Search NIH Clinical Center for Pleural Disease

Cochrane evidence based reviews: pleural diseases

Genetic Tests for Pleural Disease

Genetic tests related to Pleural Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Pleura 29

Anatomical Context for Pleural Disease

MalaCards organs/tissues related to Pleural Disease:

Lung, Heart, Breast, B Cells, Testes, T Cells, Thyroid

Publications for Pleural Disease

Articles related to Pleural Disease:

(show top 50) (show all 1357)
# Title Authors PMID Year
Adequate nephroprotection reduces renal complications after hyperthermic intrathoracic chemotherapy. 42
31602673 2019
Steroid therapy and outcome of parapneumonic pleural effusions (STOPPE): Study protocol for a multicenter, double-blinded, placebo-controlled randomized clinical trial. 42
31651842 2019
Clinical value of haptoglobin and soluble CD163 testing for the differential diagnosis of tuberculous and malignant pleural effusions. 42
31626097 2019
Evaluation of adenosine deaminase activity in the Mycobacterium tuberculosis culture supernatants. 54 61
10596453 1999
Canine and Feline Exudative Pleural Diseases. 61
31813554 2020
Use of chest CT scan scoring system for diagnostic and therapeutic decision making in pleural effusion. 61
31994852 2020
Detection of TGF-β in pleural effusions for diagnosis and prognostic stratification of malignant pleural mesothelioma. 61
31778960 2020
Clinical feature of diagnostic challenging cases for pleural biopsy in patient with malignant pleural mesothelioma. 61
31981139 2020
Twenty-five years of Respirology: Advances in pleural disease. 61
31840885 2020
The pleura and the endocrine system. 61
31918926 2020
[The occurrence of asbestos-related diseases among former employees of asbestos processing plants in Poland]. 61
31682242 2019
Review of the British Thoracic Society Winter Meeting 2018, 5-7 December 2018, London, UK. 61
31383777 2019
IgG4-related pleural disease in a patient with a history of unknown origin acute pancreatitis: a case report and review of the literature. 61
30618348 2019
Fluid Infusion Through Chest Tube to Facilitate Pleural Procedures: A Feasibility Study. 61
31876537 2019
Pleural Effusion IL-33/sST2 Levels and Effects of Low and High IL-33/sST2 Levels on Human Mesothelial Cell Adhesion and Migration. 61
31429014 2019
Confocal Laser Endomicroscopy as a Guidance Tool for Pleural Biopsies in Malignant Pleural Mesothelioma. 61
31075217 2019
State of the Art: Interventional Pulmonology. 61
31678309 2019
Synthetic hydrosilicate nanotubes induce low pro-inflammatory and cytotoxic responses compared to natural chrysotile in lung cell cultures. 61
31628893 2019
Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets. 61
31537895 2019
Competence in pleural procedures. 61
30394712 2019
Thoracic Manifestations of Rheumatoid Arthritis. 61
31376890 2019
Pleural Diseases: Pleurodesis via Indwelling Pleural Catheter, Dasatinib-induced Pleural Effusion, and IL-27 in Tuberculosis Pleural Effusion. 61
31246494 2019
High-throughput autoantibody analysis in malignant pleural effusion and tuberculosis pleural effusion. 61
31567996 2019
Presence of innate lymphoid cells in pleural effusions of primary and metastatic tumors: Functional analysis and expression of PD-1 receptor. 61
30856277 2019
Contemporary approach to the patient with malignant pleural effusion complicating lung cancer. 61
31516898 2019
Chronic follicular pleuritis: a B cell-rich form of nonspecific pleuritis/fibrosis. 61
31054896 2019
Multidisciplinary approach to connective tissue disease (CTD) related pleural effusions: a four-year retrospective evaluation. 61
31455276 2019
The Geriatric Patient: The Ideal One for Chest Ultrasonography? A Review From the Chest Ultrasound in the Elderly Study Group (GRETA) of the Italian Society of Gerontology and Geriatrics (SIGG). 61
31399360 2019
Ultrasound elastography: a novel tool for the differential diagnosis of pleural effusion. 61
31151959 2019
Indwelling pleural catheters: an overview and real-life experience. 61
31120124 2019
Dual RNA-seq in Streptococcus pneumoniae Infection Reveals Compartmentalized Neutrophil Responses in Lung and Pleural Space. 61
31409659 2019
Left Lung Neoplasms and Bilateral Pleural Effusion Combined Elevated Carcinoembryonic Antigen in Pleural Effusion with Negative Result of Thoracoscopy Pleural Biopsy Misdiagnosed as Lung Carcinoma Ultimately Confirmed Pulmonary Sarcomatoid Carcinoma by CT-guided Percutaneous Lung Biopsy: a Case Report and Literature Review. 61
31414757 2019
Safety and complications of medical thoracoscopy in the management of pleural diseases. 61
31291926 2019
Prospective Study of the Utility of Computed Tomography Triage of Pleural Biopsy Strategies in Patients With Pleural Diseases. 61
31211722 2019
Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice. 61
31022494 2019
Application of Lung Ultrasound in Critical Care Setting: A Review. 61
31565634 2019
Pleural Disease in Women. 61
31525815 2019
Clinical Impact of a Pleural Unit in a Tertiary Level Hospital. 61
31253375 2019
Physiologic Basis of Symptoms in Pleural Disease. 61
31525806 2019
Pleural Diseases. 61
31525804 2019
Diffusion-Weighted Imaging Can Differentiate between Malignant and Benign Pleural Diseases. 61
31212757 2019
[Medical thoracoscopy in respiratory medicine: The Liège University Hospital experience]. 61
31030998 2019
Pleurodesis. 61
31525812 2019
What's the Score? Do Pleural Effusion Clinical Scoring Systems Help in Management of Disease? 61
31525814 2019
Development and Maintenance of a Pleural Disease Service: Role of the "Pleurologist". 61
31525805 2019
Thematic series: Novel insights in pleural diseases: Pleural disease: A continuously improved information. 61
30953578 2019
Nodules and masses are associated with malignant pleural effusion in dogs and cats but many other intrathoracic CT features are poor predictors of the effusion type. 61
30557908 2019
Contemporary Concise Review 2018: Lung cancer and pleural disease. 61
30772946 2019
Orphan Lung Diseases. 61
30955517 2019
New cost-effective pleural procedure training: manikin-based model to increase the confidence and competency in trainee medical officers. 61
30992415 2019

Variations for Pleural Disease

Expression for Pleural Disease

Search GEO for disease gene expression data for Pleural Disease.

Pathways for Pleural Disease

Pathways related to Pleural Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes

GO Terms for Pleural Disease

Cellular components related to Pleural Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.36 MSLN MIRLET7B MIRLET7A1 MIR625 MIR29C MIR223

Biological processes related to Pleural Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.58 MIR29C MIR125B1 MIR125A
2 negative regulation of inflammatory response GO:0050728 9.56 MIR223 MIR138-1 MIR124-1 ADA
3 miRNA mediated inhibition of translation GO:0035278 9.46 MIRLET7A1 MIR138-1 MIR125B1 MIR124-1
4 negative regulation of gene expression GO:0010629 9.43 MIR29C MIR138-1 MIR125A MIR124-1 FLCN DICER1
5 negative regulation of interleukin-6-mediated signaling pathway GO:0070104 9.37 MIRLET7A1 MIR125B1
6 positive regulation of vascular smooth muscle cell differentiation GO:1905065 9.32 MIR125B1 MIR124-1
7 gene silencing by miRNA GO:0035195 9.28 MIRLET7B MIRLET7A1 MIR32 MIR29C MIR223 MIR138-1

Molecular functions related to Pleural Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.28 MIRLET7B MIRLET7A1 MIR32 MIR29C MIR223 MIR138-1

Sources for Pleural Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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