Pleural Empyema

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Pleural Empyema

MalaCards integrated aliases for Pleural Empyema:

Name: Pleural Empyema 12 58 15 17
Empyema 12 54 15 17 70
Empyema, Pleural 44 70
Pyothorax 12 32
Empyema Without Mention of Fistula 12
Empyema of Pleura Without Fistula 12
Pleural Empyema with No Fistula 12
Empyema with Pleural Fistula 12
Pleural Empyema with Fistula 12
Abscess of Pleural Cavity 12
Empyema with No Fistula 12
Empyema with Fistula 12
Purulent Pleuritis 12
Abscess of Thorax 12
Empyema of Pleura 12
Purulent Pleurisy 12
Empyema, Chest 12
Thorax Abscess 12
Lung Empyema 12


Orphanet epidemiological data:

pleural empyema
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe);


Orphanet: 58  
Rare respiratory diseases

External Ids:

Disease Ontology 12 DOID:3798
MeSH 44 D016724
NCIt 50 C45692
SNOMED-CT 67 196069007
ICD10 32 J86 J86.0 J86.9
UMLS via Orphanet 71 C0014013
Orphanet 58 ORPHA449266
UMLS 70 C0014009 C0014013

Summaries for Pleural Empyema

Disease Ontology : 12 A soft tissue infectious disease that involves accumulation of pus in the pleural cavity as a result of infection within the lung (pneumonia) or a lung abscess spreading into the space. The symptoms include cough, fever, chest pain, sweating and shortness of breath.

MalaCards based summary : Pleural Empyema, also known as empyema, is related to subdural empyema and mediastinitis. An important gene associated with Pleural Empyema is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and C-MYB transcription factor network. The drugs Cefazolin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and colon, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 73 Pleural empyema is a collection of pus in the pleural cavity caused by microorganisms, usually bacteria.... more...

Related Diseases for Pleural Empyema

Diseases related to Pleural Empyema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 976)
# Related Disease Score Top Affiliating Genes
1 subdural empyema 32.9 F2 CRP
2 mediastinitis 30.8 F2 CRP CD4 ALB
3 pulmonary tuberculosis 30.8 IL6 ALB ADA
4 lung abscess 30.8 IL6 CRP CD4 ALB
5 cerebritis 30.7 CRP CD4
6 pericarditis 30.7 IL6 CRP ALB ADA
7 hemopericardium 30.6 PLG F2 CRP
8 actinomycosis 30.6 IL6 CRP CD4 ALB
9 orbital cellulitis 30.4 TNFRSF8 CRP CD4
10 dental caries 30.4 CRP CD79A ALB
11 cholecystitis 30.4 GPT F2 ALB
12 cavernous sinus thrombosis 30.4 F2 CRP
13 lemierre's syndrome 30.4 F2 CRP
14 appendicitis 30.4 IL6 CRP ALB
15 pyomyositis 30.3 CRP CD4
16 constrictive pericarditis 30.3 CRP ALB ADA
17 nocardiosis 30.3 CRP CD4
18 otitis media 30.3 PLG IL6 CRP CD79A ALB
19 pulmonary embolism 30.3 F2 CRP ALB
20 thrombophlebitis 30.2 PLG F2 CRP ALB
21 yellow nail syndrome 30.2 ALB ADA
22 epidural abscess 30.2 F2 CRP CD4 ALB
23 gastroenteritis 30.2 IL6 CRP ALB
24 mucormycosis 30.1 CRP CD4 ALB
25 pleural disease 30.1 IL6 CRP CD4 ALB ADA
26 chlamydia 30.0 IL6 CRP CD79A
27 brain edema 30.0 IL6 CRP ALB
28 brucellosis 30.0 IL6 CRP ADA
29 chickenpox 30.0 IL6 CRP CD4 ALB ADA
30 pulmonary disease, chronic obstructive 30.0 IL6 CRP CD4 ALB
31 bacterial meningitis 30.0 IL6 CRP ALB
32 rheumatoid arthritis interstitial lung disease 30.0 CRP CD4
33 meningoencephalitis 30.0 IL6 CRP CD79A CD4 ALB
34 central nervous system tuberculosis 30.0 CD4 ADA
35 cauda equina syndrome 30.0 F2 CRP
36 endocarditis 30.0 IL6 F2 CRP ALB
37 paranasal sinus disease 30.0 IL6 CRP CD4
38 volvulus of midgut 29.9 GPT CRP ALB
39 neuroretinitis 29.9 CRP CD4
40 aspiration pneumonitis 29.9 CRP ALB
41 cholelithiasis 29.9 GPT CRP ALB
42 bronchitis 29.9 IL6 CRP ALB
43 meningitis 29.9 IL6 CRP ALB ADA
44 infective endocarditis 29.9 IL6 F2 CRP
45 cranial nerve palsy 29.9 CRP CD4 ALB
46 chronic meningitis 29.9 CRP CD4 ALB
47 vaginal discharge 29.9 IL6 CRP CD4 ALB
48 klebsiella pneumonia 29.9 IL6 CRP CD4 ALB
49 streptococcus pneumonia 29.9 IL6 CRP CD4 ALB
50 amebiasis 29.8 CD79A CD4 ALB

Graphical network of the top 20 diseases related to Pleural Empyema:

Diseases related to Pleural Empyema

Symptoms & Phenotypes for Pleural Empyema

MGI Mouse Phenotypes related to Pleural Empyema:

# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 ADA ALB BCL6 CD4 CD79A F2
2 homeostasis/metabolism MP:0005376 10.13 ADA ALB BCL6 CD4 CD79A CRP
3 hematopoietic system MP:0005397 10.11 ADA BCL6 CD4 CD79A IL6 NCAPH2
4 endocrine/exocrine gland MP:0005379 10.1 ADA ALB BCL6 CD4 F2 IL6
5 immune system MP:0005387 10.1 ADA ALB BCL6 CD4 CD79A CRP
6 mortality/aging MP:0010768 9.77 ADA ALB BCL6 CD4 CD79A F2
7 liver/biliary system MP:0005370 9.7 ADA ALB BCL6 CD79A IL6 PDLIM7
8 neoplasm MP:0002006 9.1 ALB CD79A IL6 PAX5 PLG SDC1

Drugs & Therapeutics for Pleural Empyema

Drugs for Pleural Empyema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Cefazolin Approved Phase 4 25953-19-9 33255 656510
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3 Tissue Plasminogen Activator Phase 4
4 Plasminogen Phase 4
5 Fibrinolytic Agents Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Anti-Bacterial Agents Phase 4
8 Anti-Infective Agents Phase 4
9 Clindamycin palmitate Phase 4
10 Clindamycin phosphate Phase 4
Cefotaxime Approved Phase 2 63527-52-6 456256 5742673
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
Ranitidine Approved, Withdrawn Phase 2 66357-35-5, 66357-59-3, 82530-72-1 3001055
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
15 Ranitidine bismuth citrate Phase 2
16 Gastrointestinal Agents Phase 2
17 Hormone Antagonists Phase 2
18 Antineoplastic Agents, Hormonal Phase 2
19 glucocorticoids Phase 2
20 Hormones Phase 2
21 Antiemetics Phase 2
22 Anti-Inflammatory Agents Phase 2
Amoxicillin Approved, Vet_approved 26787-78-0 33613
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
25 Amoxicillin-Potassium Clavulanate Combination
26 Clavulanic Acids
27 beta-Lactamase Inhibitors
28 Anesthetics

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double Blind, Controlled Trial to Evaluate Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Pleural Empyema Completed NCT01246453 Phase 4 Intrapleurally Alteplase vs Intrapleurally Urokinase
2 Intrapleural Tissue Plasminogen Activator and Deoxyribonuclease Therapy Versus Early Medical Thoracoscopy for Treatment of Pleural Infection: A Randomized Clinical Trial Completed NCT03468933 Phase 4 tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase)
3 A Study to Evaluate the Efficacy and Safety of a Single Dose of an Injectable Antibiotic for the Prophylaxis of Surgical Site and Pleural Space Infection After Medical Thoracoscopy Completed NCT02446782 Phase 4 Cefazolin
4 Multicentre Randomized Double-Blinded Trial of Intrapleural Dornase Alfa and Urokinase vs Urokinase Alone for Complicated Parapneumonic Effusions in Children Unknown status NCT00502632 Phase 2, Phase 3 Urokinase and Dornase alfa;Urokinase
5 Prospective Randomized Study Comparing the Efficacy and Safety of Pleural Drainage by Video-Assisted Thoracoscopic With Pleural Drainage by Percutaneous Drain Associated With Urokinase in the Treatment of Parapneumonic Pleural Effusion in Children Unknown status NCT02165891 Phase 3 insertion of a chest drain with urokinase instillation
6 Drainage is Not Necessary Procedure After Laparoscopic Cholecystectomy Due to Severe Acute Cholecystitis Unknown status NCT01625247 Phase 3
7 Thoracoscopy Versus Fibrinolysis in Children With Empyema Completed NCT00323531 Phase 2, Phase 3
8 Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial) Completed NCT01717742 Phase 3 TPA (Tissue Plasminogen Activator);DNase
9 Exploratory Multicentre Clinical Trial to Compare the Efficacy of Urokinase Versus Video-assisted Thoracoscopic for Treatment of Complicated Parapneumonic Empyema in Childhood Completed NCT00798278 Phase 3 Urokinase
10 KatGuide-trial. KatGuide Method Versus Conventional Method at Insertion of Chest Tube. A Randomized, Parallel Group, Controlled Trial. Completed NCT01522885 Phase 3
11 A Randomized Controlled Study of Early Mini-invasive Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusions or Pleural Empyema - ESMITE (European Study on Mini-invasive Thoracoscopy in Empyema) Terminated NCT00234208 Phase 3
12 Prospective Randomized Trial: Fibrinolysis With tPA (Tissue Plasminogen Activator) Versus tPA and DNAse in Children With Empyema Withdrawn NCT01862458 Phase 3
14 Urokinase Versus Primary Video-Assisted Thorascopic Surgery for Empyema Completed NCT00144950 Phase 1 insertion of a chest drain with urokinase instillation
15 Randomized Comparison of Two Dose and Frequency Regimens of Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion Unknown status NCT00103766 Alteplase
16 A Randomized Controlled Study of Fibrinolytic Treatment for Purulent Pleural Effusion in Children Unknown status NCT03716375 Intrapleural Medications
17 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Among Tuberculous Pleurisy and Malignant Pleural Effusion Patients Unknown status NCT00313066
18 Evaluation de la Mesure du Taux de la Procalcitonine Dans Les Liquides Pleuraux Completed NCT01011881
19 Response to Instillation of Activase in the Pleural Cavity vs Placebo in the Management of Complicated Pleural Effusion/Empyema Completed NCT00468104 Alteplase;Placebo
20 Retrospective Review on Patients With Culture Negative Empyema Completed NCT04477980
21 An Observational Study of Chest Wall Motion Analysis in Disease Completed NCT02958683
22 Incidence, Risk Factors and Outcome of Empyema Following Pneumonectomy for Non Small Cell Lung Cancer (NSCLC) Completed NCT01837186
23 Procoagulant Activity in Patients With Community Acquired Pneumonia, Pleural Effusion and Empyema Completed NCT01178580
24 Phase 1: Study of the Osteogenic Potential of Human Maxillary Sinus Shneiderian Membrane Completed NCT02676921
25 VATS( Video-Assisted Thoracoscopy ) Compared to Reinsertion of a Thoracostomy Tube for Persistent Haemothorax A Single Center Prospective Randomized Study Completed NCT02014077
26 To Drain or Not to Drain in Laparoscopic Cholecystectomy for the Patients With Acutely Inflamed Gallbladder ; a Multicenter Randomized Controlled Trial Completed NCT02027402
27 Video Assisted Thoracoscopic Decortication Versus Interventional Radiology Guided Chest Tube Insertion With Fibrinolytics for the Management of Empyema (DICE Trial) Recruiting NCT03584113
28 Management of Pleural Space Infections Recruiting NCT03873766 Intrapleural Medications
29 Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural Infections Recruiting NCT04350502 Amoxicillin + clavulanic acid
30 Suturing With U-technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube Drain - A Single-centre Open-label Randomized Prospective Trial (SUTURE TRIAL) Recruiting NCT04193241
31 Prospective Evaluation of 14F Thal Tube vs 28 French Chest Tube for Hemothorax and Use of Maximum Barrier Precautions Enrolling by invitation NCT03167723
32 A Comparative Study : Medical Thoracoscopy Versus Tube Thoracostomy in Early Management of Empyema . Not yet recruiting NCT03859206
33 Intrapleural Fibrinolysis and DNase Versus VATS for the Treatment of Pleural Empyema: a Randomized, Controlled Trial Not yet recruiting NCT04095676
34 Early Results of Empyema Thoracis Treatment in Children by Video-assisted Thoracoscopic Surgery Not yet recruiting NCT04177550
35 A Multicenter Observational Study About the Clinical Feature and Microbiology Characteristics of Empyema in Children Not yet recruiting NCT04695275
36 Early Intervention for Complicated Parapneumonic Effusion: Randomized Controlled Trial for Fibrinolytic Therapy Versus VATs Decortication Suspended NCT03583931 Fibrinolytic Therapy
37 Prospective Randomized Trial Comparing Navigation With Xperguide vs. Conventional Methods During Percutaneous Image Guided Procedures Terminated NCT01287013

Search NIH Clinical Center for Pleural Empyema

Cochrane evidence based reviews: empyema, pleural

Genetic Tests for Pleural Empyema

Anatomical Context for Pleural Empyema

MalaCards organs/tissues related to Pleural Empyema:

Lung, Brain, Colon, Neutrophil, Skin, Bone Marrow, Eye

Publications for Pleural Empyema

Articles related to Pleural Empyema:

(show top 50) (show all 9672)
# Title Authors PMID Year
Evaluation of polymerase chain reaction and adenosine deaminase assay for the diagnosis of tuberculous effusions in children. 61 54
16737998 2006
Tissue plasminogen activator combined with human recombinant deoxyribonuclease is effective therapy for empyema in a rabbit model. 54 61
16778278 2006
Diagnostic yield of adenosine deaminase in bronchoalveolar lavage. 54 61
15689096 2004
Immune status with empyema thoracis. 54 61
15107509 2004
[Diagnosis and treatment of tuberculous pleurisy--with special reference to the significance of measurement of pleural fluid cytokines]. 54 61
15168435 2004
The implication of elevated carcinoembryonic antigen level in pleural fluid of patients with non-malignant pleural effusion. 54 61
14629653 2003
Successful treatment of empyema thoracis with human recombinant deoxyribonuclease. 54 61
12668806 2003
Effects of streptokinase and deoxyribonuclease on viscosity of human surgical and empyema pus. 54 61
10858409 2000
Fibrinolytic and inflammatory processes in pleural effusions. 61 54
7489803 1995
Value of adenosine deaminase in the diagnosis of tuberculous pleural effusions in young patients in a region of high prevalence of tuberculosis. 61 54
7638798 1995
[Clinical evaluation of pleural effusion--carcinoembryonic antigen (CEA) and adenosine deaminase (ADA) activities in pleural fluids]. 54 61
2077254 1990
[Gamma interferon and adenosine deaminase in pleuritis]. 61 54
2110605 1990
Empyema thoracis presented as giant back abscess. 61
33680277 2021
NOX1 Promotes Mesothelial-Mesenchymal Transition through Modulation of Reactive Oxygen Species-mediated Signaling. 61
33513310 2021
Fibrinolysis with Lower Dose Urokinase in Patients with Complicated Parapneumonic Effusion. 61
33327051 2021
Early detection of euglycemic ketoacidosis during thoracic surgery associated with empagliflozin in a patient with type 2 diabetes: A case report. 61
32686282 2021
Endothelial Cell Protein C Receptor Deficiency Attenuates Streptococcus pneumoniae-induced Pleural Fibrosis. 61
33600743 2021
Measuring complications of serious pediatric emergencies using ICD-10. 61
33374034 2021
A case of esophageal achalasia presenting with empyema and septic shock differentiated from esophageal rupture. 61
33527334 2021
Intracranial hematoma and abscess after neuraxial analgesia and anesthesia: a review of the literature describing 297 cases. 61
33441431 2021
Prophylactic Bronchial Stump Support With Intrathoracic Muscle Flap Transposition. 61
33555686 2021
The Man Behind the Clagett Procedure: Dr Oscar Theron "Jim" Clagett. 61
33248126 2021
Role of medical thoracoscopy in the treatment of complicated parapneumonic effusions. 61
33687009 2021
Bacterial Superinfections Among Persons With Coronavirus Disease 2019: A Comprehensive Review of Data From Postmortem Studies. 61
33732753 2021
A prospective multicentre study of per-oral endoscopic myotomy (POEM) for achalasia in Australia. 61
33611796 2021
Pulmonary Infections and Surgical Complications in a Young Girl with Signal Transducer and Activator of Transcription 3 Loss-of-Function Mutation Hyperimmunoglobulin E Syndrome: A Case Report. 61
33734873 2021
Epidemiology and prognostic factors of pleural empyema. 61
33785584 2021
Lung Resection in Children with Necrotizing Pneumonia: Outcome and Follow-up. 61
33677824 2021
[Indications and results of pulmonary resections in a developing country]. 61
33341327 2021
Empyema thoracis: an unreported complication of an infected renal cyst. 61
33769673 2021
Pleural empyema in children - benefits of primary thoracoscopic treatment. 61
33786143 2021
Diagnosis of pleural empyema/parapneumonic effusion by next-generation sequencing. 61
33689538 2021
Clinical reasoning in canine vestibular syndrome: Which presenting factors are important? 61
33739504 2021
Differential impacts of postoperative complications on patients' survival in completely resected non-small-cell lung cancer. 61
33687642 2021
Early use of autologous blood patch pleurodesis in children is successful in resolving persistent air leaks. 61
33189301 2021
To drain or not to drain? Abscess or empyema? 61
33177229 2021
Variation in Management and Outcomes of Children With Complicated Pneumonia. 61
33579749 2021
Neuroradiology of infectious diseases. 61
33741796 2021
Negative-pressure wound therapy in combination with bronchial occlusion to treat bronchopleural fistula: a case report. 61
33651250 2021
Suspected chronic subdural haemorrhage as a sequela of subdural empyema in an Irish Setter. 61
33783835 2021
Early intravenous immunoglobulin therapy for group A β-haemolytic streptococcal meningitis with toxic shock syndrome. 61
33664027 2021
Thoracic duct injury after decortication of lung, new technique to repair thoracic duct in this challenging situation: A case report. 61
33653153 2021
Cavitary Coccidioidomycosis: Impact of azole antifungal therapy. 61
33724424 2021
Management of thoracic empyema in children: a survey of the Australia and New Zealand Association of Paediatric Surgeons (ANZAPS). 61
33751198 2021
A case of primary pulmonary Schizophyllum commune empyema treated with video-assisted thoracoscopic decortication. 61
33118109 2021
Conservative and surgical modalities in the management of paediatric parapneumonic effusion and empyema: a protocol for a living systematic review and network meta-analysis. 61
33762243 2021
Video-Assisted Thoracoscopic Surgery (VATS) in a 20-Day-Old Newborn With Empyema Thoracis. 61
33713069 2021
The complex advanced endoscopic approach in the treatment of choledocholitiasis and empyema of gallbladder. 61
33682902 2021
Preoperative undernutrition predicts postoperative complications of acute empyema. 61
33437877 2021
Daptomycin for the successful treatment of postoperative methicillin-resistant Staphylococcus aureus empyema: a case report. 61
33645466 2021

Variations for Pleural Empyema

Expression for Pleural Empyema

Search GEO for disease gene expression data for Pleural Empyema.

Pathways for Pleural Empyema

GO Terms for Pleural Empyema

Cellular components related to Pleural Empyema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.46 IL6 F2 CD4 ALB
2 external side of plasma membrane GO:0009897 9.35 SDC1 F2 CD79A CD4 ADA
3 condensin complex GO:0000796 8.8 SMC4 SMC2 NCAPH2

Biological processes related to Pleural Empyema according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.8 SDC1 IL6 CD4 BCL6
2 cellular protein metabolic process GO:0044267 9.73 PLG IL6 F2 ALB
3 negative regulation of fibrinolysis GO:0051918 9.48 PLG F2
4 negative regulation of lipid storage GO:0010888 9.46 IL6 CRP
5 acute-phase response GO:0006953 9.43 IL6 F2 CRP
6 kinetochore organization GO:0051383 9.4 SMC4 SMC2
7 meiotic chromosome segregation GO:0045132 9.37 SMC4 SMC2
8 chromosome condensation GO:0030261 9.33 SMC4 SMC2 NCAPH2
9 germinal center B cell differentiation GO:0002314 9.32 IL6 ADA
10 mitotic chromosome condensation GO:0007076 9.13 SMC4 SMC2 NCAPH2
11 meiotic chromosome condensation GO:0010032 8.8 SMC4 SMC2 NCAPH2

Sources for Pleural Empyema

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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