MCID: PLR007
MIFTS: 50

Pleural Empyema

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Pleural Empyema

MalaCards integrated aliases for Pleural Empyema:

Name: Pleural Empyema 12 59 15
Empyema 12 55 15 73
Empyema, Pleural 44 73
Empyema Without Mention of Fistula 12
Empyema of Pleura Without Fistula 12
Pleural Empyema with No Fistula 12
Empyema with Pleural Fistula 12
Pleural Empyema with Fistula 12
Abscess of Pleural Cavity 12
Empyema with No Fistula 12
Empyema with Fistula 12
Purulent Pleuritis 12
Abscess of Thorax 12
Empyema of Pleura 12
Purulent Pleurisy 12
Empyema, Chest 12
Thorax Abscess 12
Lung Empyema 12
Pyothorax 12

Characteristics:

Orphanet epidemiological data:

59
pleural empyema
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 59  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:3798
ICD10 33 J86 J86.9 J86.0
MeSH 44 D016724
NCIt 50 C45692
Orphanet 59 ORPHA449266
UMLS via Orphanet 74 C0014013

Summaries for Pleural Empyema

Disease Ontology : 12 A soft tissue infectious disease that involves accumulation of pus in the pleural cavity as a result of infection within the lung (pneumonia) or a lung abscess spreading into the space. The symptoms include cough, fever, chest pain, sweating and shortness of breath.

MalaCards based summary : Pleural Empyema, also known as empyema, is related to subdural empyema and pleurisy. An important gene associated with Pleural Empyema is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Aurora B signaling and Primary immunodeficiency. The drugs Tissue Plasminogen Activator and Plasminogen have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Pleural empyema An empyema (from Greek ἐμ�?ύημα, "abscess")is a collection of pus in the pleural cavity... more...

Related Diseases for Pleural Empyema

Diseases related to Pleural Empyema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)
# Related Disease Score Top Affiliating Genes
1 subdural empyema 33.6 CRP P3H2 PGBD1
2 pleurisy 30.5 ADA CRP
3 pericarditis 30.2 ADA CRP
4 bronchopneumonia 29.9 HSF4 P3H2
5 orbital cellulitis 29.9 CRP PGBD1
6 bacterial pneumonia 29.7 ADA CRP
7 pulmonary aspergilloma 29.6 CRP P3H2
8 suppurative otitis media 29.6 CRP HSF4
9 pericardial effusion 29.5 ADA CRP
10 tuberculous empyema 11.3
11 pyometritis 11.1
12 anaerobic pneumonia 11.1
13 sinusitis 10.3
14 pneumonia 10.3
15 gastrointestinal tuberculosis 10.2 ADA CRP
16 abdominal tuberculosis 10.2 ADA CRP
17 pneumothorax 10.2
18 tuberculous peritonitis 10.2 ADA CRP
19 pyelitis 10.2 CRP P3H2
20 dental pulp calcification 10.2 CTSC PDLIM7
21 scarlet fever 10.1 HSF4 P3H2
22 suppurative lymphadenitis 10.1 HSF4 P3H2
23 orbital disease 10.1 CRP PGBD1
24 mediastinitis 10.1
25 pleural disease 10.1 ADA CRP
26 acute orbital inflammation 10.1 CRP PGBD1
27 frontal sinusitis 10.1
28 lung abscess 10.1
29 primary bacterial infectious disease 10.0 ADA CRP
30 arthritis 10.0
31 lemierre's syndrome 10.0
32 cellulitis 10.0
33 pneumothorax, primary spontaneous 10.0
34 liver cirrhosis 10.0
35 aortic aneurysm 10.0
36 renal tuberculosis 10.0 CD79A CRP
37 hypersensitivity vasculitis 10.0 CD79A CRP
38 hypersensitivity reaction type iii disease 10.0 CD79A CRP
39 otitis media 9.9
40 mastoiditis 9.9
41 pharyngitis 9.9
42 splenic abscess 9.9
43 haemophilus influenzae 9.9
44 henoch-schoenlein purpura 9.9 CD79A CRP
45 esophageal cancer 9.9
46 malignant fibroxanthoma 9.9
47 idiopathic interstitial pneumonia 9.9
48 pyoderma 9.9
49 histiocytoma 9.9
50 fibrous histiocytoma 9.9

Graphical network of the top 20 diseases related to Pleural Empyema:



Diseases related to Pleural Empyema

Symptoms & Phenotypes for Pleural Empyema

GenomeRNAi Phenotypes related to Pleural Empyema according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.28 CRP CTSC LIN52
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.28 CRP LIN52
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.28 CTSC
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.28 CTSC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.28 CRP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.28 CRP

Drugs & Therapeutics for Pleural Empyema

Drugs for Pleural Empyema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Tissue Plasminogen Activator Phase 4,Phase 3
2 Plasminogen Phase 4,Phase 3
3 Fibrinolytic Agents Phase 4,Phase 3,Not Applicable
4 Anti-Bacterial Agents Phase 3,Not Applicable
5
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
6
Calcitonin gene-related peptide Investigational 83652-28-2
7 Analgesics Not Applicable
8 Tin Fluorides Not Applicable
9 Antibiotics, Antitubercular Not Applicable
10 Anesthetics Not Applicable
11 calcitonin
12 Bone Density Conservation Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema Completed NCT01246453 Phase 4 Intrapleurally Alteplase vs Intrapleurally Urokinase
2 Fibrinolytic Therapy Versus Medical Thoracoscopy Recruiting NCT03213834 Phase 4 tPA;DNase
3 Dornase Alfa and Urokinase for Kids With Pleural Empyema Unknown status NCT00502632 Phase 2, Phase 3 Urokinase and Dornase alfa;Urokinase
4 Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial) Completed NCT01717742 Phase 3 tPA;DNase
5 Early Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural Empyema Terminated NCT00234208 Phase 3
6 A Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia Withdrawn NCT03006679 Phase 3 Meropenem-Vaborbactam;Piperacillin/Tazobactam
7 The Fast Track Rehabilitation in Thoracic Surgery Unknown status NCT02831140 Not Applicable
8 Procalcitonin in Pleural Pleuritis Completed NCT01011881
9 Efficacy of Fibrinolytic Agents in Complicated Pleural Effusion Not yet recruiting NCT03716375 Not Applicable Intrapleural Medications

Search NIH Clinical Center for Pleural Empyema

Cochrane evidence based reviews: empyema, pleural

Genetic Tests for Pleural Empyema

Anatomical Context for Pleural Empyema

MalaCards organs/tissues related to Pleural Empyema:

41
Lung, Liver, Bone, Brain, Testes, Kidney, B Cells

Publications for Pleural Empyema

Articles related to Pleural Empyema:

(show top 50) (show all 970)
# Title Authors Year
1
Treatment of chronic tuberculous empyema by intrapleural injection of anhydrous ethanol. ( 30505678 )
2019
2
Transforming growth factor beta1 (TGF-A91) levels in a rat model of induced pleural empyema. ( 29513814 )
2018
3
First case of pleural empyema and pulmonary abscess caused by Eggerthia catenaformis. ( 29371096 )
2018
4
A rare case of pericarditis and pleural empyema secondary to transdiaphragmatic extension of pyogenic liver abscess. ( 29334903 )
2018
5
Cryptococcus neoformans empyema in a patient receiving ibrutinib for diffuse large B-cell lymphoma and a review of the literature. ( 30021735 )
2018
6
Free musculocutaneous flap transfer for refractory chronic empyema with chest wall sinus in a 43-year-old male with hemophilia A. ( 30069395 )
2018
7
Sepsis and Pleural Empyema Caused by Streptococcus pyogenes after Influenza A Virus Infection. ( 30345134 )
2018
8
Sphenoidal sinogenic extradural empyema associated with juvenile myelomonocytic leukemia. ( 30368391 )
2018
9
Septicemia, Meningitis and Bilateral Subdural Empyema in an Infant Caused by Staphylococcus aureus. ( 30487513 )
2018
10
Subdural empyema complicated with intracranial hemorrhage in a postradiotherapy nasopharyngeal carcinoma patient: A case report and review of literature. ( 30510950 )
2018
11
A Unique Case of Concurrent Long Bone Osteomyelitis and Empyema Caused by Fusobacterium nucleatum. ( 29869856 )
2018
12
Pancreaticopleural fistula: a rare cause of pleural empyema. ( 29716451 )
2018
13
Risk of pleural empyema in patients with schizophrenia: a nationwide propensity-matched cohort study in Taiwan. ( 29982211 )
2018
14
International survey of paediatric infectious diseases consultants on the management of community-acquired pneumonia complicated by pleural empyema. ( 30051535 )
2018
15
A Retrospective Analysis of Anaerobic Bacteria Isolated in 236 Cases of Pleural Empyema and their Prevalance of Antimicrobial Resistance in Turkey. ( 30146848 )
2018
16
Lung decortication in phase III pleural empyema by video-assisted thoracoscopic surgery (VATS)-results of a learning curve study. ( 30174878 )
2018
17
Dropped gallstones causing abdominal wall abscess and pleural empyema: a case series. ( 30373501 )
2018
18
Achromobacter xylosoxidans/denitrificans bacteremia and subsequent fatal Escherichia coli/Streptococcus anginosus pleural empyema. ( 30386722 )
2018
19
First Case of Pleural Empyema Caused by Staphylococcus simulans: Review of the Literature. ( 30405924 )
2018
20
Change in Bacterial Causes of Community-Acquired Parapneumonic Effusion and Pleural Empyema in Children 6 Years After 13-Valent Pneumococcal Conjugate Vaccine Implementation. ( 30407519 )
2018
21
Pleural empyema - single center experience. ( 30441991 )
2018
22
Successful treatment of pleural empyema caused by an intrathoracic esophageal fistula after iatrogenic esophageal perforation with polyglycolic acid sheets. ( 30481501 )
2018
23
Uniportal video-assisted thoracic surgery in the treatment of pleural empyema. ( 30505554 )
2018
24
Empyema Necessitans in the Setting of Methicillin-Susceptible Staphylococcus aureus Causing Pneumonia and Bacteremia. ( 29850305 )
2018
25
Acute exacerbation of idiopathic pulmonary fibrosis triggered by Aspergillus empyema. ( 29719792 )
2018
26
Interhemispheric Subdural Empyema Secondary to Sinusitis in an Adolescent Girl. ( 30539913 )
2018
27
Subdural empyema in children. ( 30014307 )
2018
28
Pyogenic brain abscess and subdural empyema: presentation, management, and factors predicting outcome. ( 30054798 )
2018
29
Massive subdural empyema. ( 30159156 )
2018
30
Subdural Empyema. ( 30234467 )
2018
31
Subdural empyema case report of a rare disease with a high mortality. ( 30442008 )
2018
32
Treatment-refractory Escherichia coli subdural empyema caused by infection of a chronic subdural hematoma in an infant. ( 30446813 )
2018
33
Lawsonella clevelandensis causing spinal subdural empyema. ( 30451005 )
2018
34
Mediastinal teratoma presenting with hemoptysis and pleuritis misdiagnosed as tuberculosis (empyema). ( 30514248 )
2018
35
Reply: a typical manifestations of tuberculous empyema an neutrophil-predominant effusions. ( 30165391 )
2018
36
Atypical manifestations of tuberculous empyema and neutrophil-predominant tuberculous pleural effusions. ( 30165694 )
2018
37
Nontyphi Salmonella Empyema with Bronchopleural Fistula in a Patient with Human Immunodeficiency Virus. ( 30009074 )
2018
38
Thoracotomy versus video-assisted thoracoscopic surgery (VATS) in stage III empyema-an analysis of 217 consecutive patients. ( 29218675 )
2018
39
Empyema necessitatis 17 years after a pneumonectomy. ( 29229298 )
2018
40
Fatal thoracic empyema involving Campylobacter rectus: A case report. ( 29325875 )
2018
41
The Efficacy of VATS and Intrapleural Fibrinolytic Therapy in Parapneumonic Empyema Treatment. ( 29343663 )
2018
42
Intrapleural Fibrinolytic Therapy for Empyema and Pleural Loculation: Knowns and Unknowns. ( 29361235 )
2018
43
Assessment of the charlson comorbidity index score, CHADS2 and CHA2DS2-VASc scores in predicting death in patients with thoracic empyema. ( 29370933 )
2018
44
Risk of empyema in patients with COPD. ( 29398913 )
2018
45
Supercharged free omental flap plombage for empyema in a patient with an artificial pericardium. ( 29415251 )
2018
46
Predictive Variables for Failure in Administration of Intrapleural Tissue Plasminogen Activator/Deoxyribonuclease in Patients With Complicated Parapneumonic Effusions/Empyema. ( 29425674 )
2018
47
Blood Culture and Pleural Fluid Culture Yields in Pediatric Empyema Patients: A Retrospective Review, 1996-2016. ( 29438130 )
2018
48
Pleural Lymphoma Associated With Chronic Empyema. ( 29439815 )
2018
49
Paediatric thoracic empyema in the tropical North Queensland region of Australia: Epidemiological trends over a decade. ( 29442395 )
2018
50
Nontraumatic First Rib Fracture and Empyema Presenting as Shoulder Pain. ( 29480922 )
2018

Variations for Pleural Empyema

Expression for Pleural Empyema

Search GEO for disease gene expression data for Pleural Empyema.

Pathways for Pleural Empyema

Pathways related to Pleural Empyema according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.81 SMC2 SMC4
2 10.52 ADA CD79A
3 10.14 SMC2 SMC4

GO Terms for Pleural Empyema

Cellular components related to Pleural Empyema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 condensin complex GO:0000796 8.62 SMC2 SMC4

Biological processes related to Pleural Empyema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome organization GO:0051276 9.37 SMC2 SMC4
2 chromosome condensation GO:0030261 9.32 SMC2 SMC4
3 mitotic chromosome condensation GO:0007076 9.26 SMC2 SMC4
4 meiotic chromosome segregation GO:0045132 9.16 SMC2 SMC4
5 kinetochore organization GO:0051383 8.96 SMC2 SMC4
6 meiotic chromosome condensation GO:0010032 8.62 SMC2 SMC4

Sources for Pleural Empyema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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