MCID: PLR007
MIFTS: 46

Pleural Empyema

Categories: Respiratory diseases, Rare diseases

Aliases & Classifications for Pleural Empyema

MalaCards integrated aliases for Pleural Empyema:

Name: Pleural Empyema 12 59 15
Empyema 12 55 73
Empyema, Pleural 44 73
Empyema Without Mention of Fistula 12
Empyema of Pleura Without Fistula 12
Pleural Empyema with No Fistula 12
Empyema with Pleural Fistula 12
Pleural Empyema with Fistula 12
Abscess of Pleural Cavity 12
Empyema with No Fistula 12
Empyema with Fistula 12
Purulent Pleuritis 12
Abscess of Thorax 12
Empyema of Pleura 12
Purulent Pleurisy 12
Empyema, Chest 12
Thorax Abscess 12
Lung Empyema 12
Pyothorax 12

Characteristics:

Orphanet epidemiological data:

59
pleural empyema
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 59  
Rare respiratory diseases


Summaries for Pleural Empyema

Disease Ontology : 12 A soft tissue infectious disease that involves accumulation of pus in the pleural cavity as a result of infection within the lung (pneumonia) or a lung abscess spreading into the space. The symptoms include cough, fever, chest pain, sweating and shortness of breath.

MalaCards based summary : Pleural Empyema, also known as empyema, is related to pleurisy and lung abscess. An important gene associated with Pleural Empyema is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Aurora B signaling and Cell cycle_Chromosome condensation in prometaphase. The drugs Fibrinolytic Agents and Plasminogen have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Pleural empyema is a collection of pus in the pleural cavity caused by microorganisms, usually bacteria.... more...

Related Diseases for Pleural Empyema

Diseases related to Pleural Empyema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 pleurisy 30.8 ADA CRP
2 lung abscess 30.2 CRP HSF4
3 pericarditis 30.2 ADA CRP
4 tuberculous empyema 11.2
5 abdominal tuberculosis 10.5 ADA CRP
6 pulmonary aspergilloma 10.5 CRP P3H2
7 tuberculous peritonitis 10.4 ADA CRP
8 acute orbital inflammation 10.4 CRP PGBD1
9 pyelitis 10.4 CRP P3H2
10 orbital cellulitis 10.4 CRP PGBD1
11 cellulitis 10.4 CRP P3H2
12 streptococcal meningitis 10.4 ADA CRP
13 viral meningitis 10.3 ADA CRP
14 subdural empyema 10.3 CRP PGBD1
15 pericardial effusion 10.2 ADA CRP
16 suppurative lymphadenitis 10.2 HSF4 P3H2
17 pneumonia 10.2
18 pleural disease 10.2 ADA CRP CTSC
19 bronchopneumonia 10.2 HSF4 P3H2
20 suppurative otitis media 10.1 CRP HSF4
21 pneumothorax 10.1
22 primary bacterial infectious disease 10.0 ADA CRP
23 mediastinitis 10.0
24 esophagitis 10.0
25 pneumothorax, primary spontaneous 9.9
26 liver cirrhosis 9.9
27 aortic aneurysm 9.9
28 aneurysm 9.9
29 peritonitis 9.8 ADA CRP
30 apnea, obstructive sleep 9.7
31 lung cancer 9.7
32 cystic fibrosis 9.7
33 lymphoma, hodgkin, classic 9.7
34 aging 9.7
35 pleuropulmonary blastoma 9.7
36 lymphoma, non-hodgkin, familial 9.7
37 myelodysplastic syndrome 9.7
38 diabetes mellitus 9.7
39 sleep apnea 9.7
40 lymphoma 9.7
41 endobronchial lipoma 9.7
42 osteomyelitis 9.7
43 disseminated intravascular coagulation 9.7
44 epidural abscess 9.7
45 pulmonary edema 9.7
46 diarrhea 9.7
47 toxic shock syndrome 9.7
48 nocardiosis 9.7
49 splenic abscess 9.7
50 pulmonary tuberculosis 9.7

Graphical network of the top 20 diseases related to Pleural Empyema:



Diseases related to Pleural Empyema

Symptoms & Phenotypes for Pleural Empyema

GenomeRNAi Phenotypes related to Pleural Empyema according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.61 LIN52 CRP CTSC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.61 LIN52 CRP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.61 CTSC
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.61 CTSC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.61 CRP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.61 CRP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.55 CTSC
8 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.55 CTSC
9 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.55 CRP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.55 CRP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.55 CTSC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.55 CRP CTSC P3H2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.55 P3H2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.55 CTSC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.55 P3H2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.55 CTSC
17 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.55 CTSC
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.55 CRP
19 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.55 CRP CTSC
20 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.55 P3H2

Drugs & Therapeutics for Pleural Empyema

Drugs for Pleural Empyema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrinolytic Agents Phase 4,Phase 3
2 Plasminogen Phase 4,Phase 3
3 Tissue Plasminogen Activator Phase 4,Phase 3
4
Meropenem Approved, Investigational Phase 3 119478-56-7 64778 441130
5
Piperacillin Approved Phase 3 66258-76-2 43672
6
Tazobactam Approved Phase 3 89786-04-9 123630
7 Anti-Bacterial Agents Phase 3,Not Applicable
8 Anti-Infective Agents Phase 3
9 beta-Lactamase Inhibitors Phase 3
10 Penicillanic Acid Phase 3
11 Piperacillin, tazobactam drug combination Phase 3
12 Thienamycins Phase 3
13
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
14
Calcitonin gene-related peptide Investigational 83652-28-2
15 Analgesics Not Applicable
16 Anesthetics Not Applicable
17 Antibiotics, Antitubercular Not Applicable
18 Tin Fluorides Not Applicable
19 Bone Density Conservation Agents
20 calcitonin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema Completed NCT01246453 Phase 4 Intrapleurally Alteplase vs Intrapleurally Urokinase
2 Fibrinolytic Therapy Versus Medical Thoracoscopy Recruiting NCT03213834 Phase 4 tPA;DNase
3 Dornase Alfa and Urokinase for Kids With Pleural Empyema Unknown status NCT00502632 Phase 2, Phase 3 Urokinase and Dornase alfa;Urokinase
4 Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial) Completed NCT01717742 Phase 3 tPA;DNase
5 A Study of Meropenem-Vaborbactam Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia Not yet recruiting NCT03006679 Phase 3 Meropenem-Vaborbactam;Piperacillin/Tazobactam
6 Early Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural Empyema Terminated NCT00234208 Phase 3
7 The Fast Track Rehabilitation in Thoracic Surgery Unknown status NCT02831140 Not Applicable
8 Procalcitonin in Pleural Pleuritis Completed NCT01011881

Search NIH Clinical Center for Pleural Empyema

Cochrane evidence based reviews: empyema, pleural

Genetic Tests for Pleural Empyema

Anatomical Context for Pleural Empyema

MalaCards organs/tissues related to Pleural Empyema:

41
Lung, Liver, Bone, Testes, Spinal Cord, Brain

Publications for Pleural Empyema

Articles related to Pleural Empyema:

(show top 50) (show all 281)
# Title Authors Year
1
Transforming growth factor beta1 (TGF-A91) levels in a rat model of induced pleural empyema. ( 29513814 )
2018
2
First case of pleural empyema and pulmonary abscess caused by Eggerthia catenaformis. ( 29371096 )
2018
3
A rare case of pericarditis and pleural empyema secondary to transdiaphragmatic extension of pyogenic liver abscess. ( 29334903 )
2018
4
Pancreaticopleural fistula: a rare cause of pleural empyema. ( 29716451 )
2018
5
Preoperative predictors of conversion in thoracoscopic surgery for pleural empyema. ( 28369294 )
2017
6
Population-based cohort study investigating the correlation of diabetes mellitus with pleural empyema in adults in Taiwan. ( 28885331 )
2017
7
Disseminated nocardiosis complicated by multiple brain abscesses and pleural empyema in a young diabetic man: a case report. ( 29154371 )
2017
8
Management of Aspergillus pleural empyema with combined systemic and intrapleural antifungal therapy in a pediatric patient: Case report. ( 28545901 )
2017
9
Boerhaave's syndrome complicated by a Saccharomyces cerevisiae pleural empyema. Case report and review of the literature. ( 29103370 )
2017
10
Surgical versus non-surgical management for pleural empyema. ( 28304084 )
2017
11
Spinal epidural empyema extending from a pleural empyema: case description and anatomical overview. ( 29122901 )
2017
12
Pediatric pleural empyema: one of the management challenges in children of Democratic Republic of Congo. ( 28673074 )
2017
13
A Simplified Technique for Drainage of Chronic Calcified Pleural Empyema. ( 28131104 )
2017
14
Propionibacterium acnes pleural empyema following medical thoracoscopy. ( 28638619 )
2017
15
Risk of developing pleural empyema in patients with stroke: a propensity-matched cohort study. ( 28698956 )
2017
16
Pneumonia with pleural empyema caused by Salmonella Typhi in an immunocompetent child living in a non-endemic country. ( 28436267 )
2017
17
Uniportal thoracoscopic decortication for pleural empyema and the role of ultrasonographic preoperative staging. ( 28108575 )
2017
18
Pleural empyema caused by incarceration and perforation of the stomach wall discovered several years later after thoracic trauma. ( 28747950 )
2017
19
Surgical Treatment of Pleural Empyema - Our Results. ( 28991771 )
2017
20
Pleural empyema and streptococcal toxic shock syndrome due to Streptococcus pyogenes in a healthy Spanish traveler in Japan. ( 28725562 )
2017
21
Etiology of parapneumonic effusion and pleural empyema in children. The role of conventional and molecular microbiological tests. ( 27296817 )
2016
22
Pleural empyema: a case of failing to see the discharge leading to discharge failure. ( 27899685 )
2016
23
An Approach to the Management of Pleural Empyema with Early Video-assisted Thoracoscopic Surgery and Early Transition to Oral Antibiotic Therapy. ( 27097620 )
2016
24
Is open decortication superior to fibrinolytic therapy as a first line treatment in the management of pleural empyema? ( 27182233 )
2016
25
Pleural Empyema Following Liver Resection: A Rare But Serious Complication. ( 27464918 )
2016
26
Double jeopardy - concurrent lung abscess and pleural empyema. ( 27208219 )
2016
27
Pleural empyema due to Salmonella enterica serovar Enteritidis in an immunocompetent elderly patient: a case report. ( 28348773 )
2016
28
Video-assisted thoracoscopic decortication for the management of late stage pleural empyema, is it feasible? ( 26933461 )
2016
29
Pneumonia and Pleural Empyema due to a Mixed Lactobacillus spp. Infection as a Possible Early Esophageal Carcinoma Signature. ( 27734016 )
2016
30
Incidence, aetiology and outcome of pleural empyema and parapneumonic effusion from 1998 to 2012 in a population of New Zealand children. ( 27059295 )
2016
31
Diffuse descending necrotising mediastinitis and pleural empyema secondary to acute odontogenic infection resulting in severe dysphagia. ( 27013653 )
2016
32
Clinical characteristics of 323 children with parapneumonic pleural effusion and pleural empyema due to community acquired pneumonia. ( 26919911 )
2016
33
Intrapleural urokinase therapy in a neonate with pleural empyema. ( 27460398 )
2016
34
P1.31: Pleural Empyema and Broncho Pleural Fistula After Lung Resection: Analyses of 29 Patients Treated in our Clinic: Track: Advanced NSCLC. ( 27676517 )
2016
35
Pleural empyema caused by Salmonella enteritidis in a patient with non-Hodgkin lymphoma. ( 27295915 )
2016
36
Stage-directed therapy of pleural empyema. ( 27815709 )
2016
37
Pleural Empyema and Aortic Aneurysm: A Retrospective National Population-Based Cohort Study. ( 26632741 )
2015
38
Etiology and Incidence of Pleural Empyema in South African Children. ( 26267310 )
2015
39
Mini-open vacuum-assisted closure therapy with instillation for debilitated and septic patients with pleural empyema. ( 26017017 )
2015
40
Efficacy of intrapleural instillation of fibrinolytics for treating pleural empyema and parapneumonic effusion: appropriateness of including paediatric trials in meta-analysis. ( 25707421 )
2015
41
Pleural empyema in a pneumonectomized patient as a complication of colonoscopy. ( 26422184 )
2015
42
EACTS expert consensus statement for surgical management of pleural empyema. ( 26254467 )
2015
43
Pleural empyema caused by Klebsiella oxytoca: A case series. ( 25677866 )
2015
44
Intrapleural administration of DNase alone for pleural empyema. ( 26885174 )
2015
45
Photo Quiz: Mysterious Objects in a Pleural Biopsy Sample from a Patient with Recurrent Pleural Empyema. ( 26089383 )
2015
46
Pediatric Pleural Empyema in the Province of Quebec: Analysis of a 10-Fold Increase Between 1990 and 2007. ( 26625364 )
2014
47
Repair of Bochdalek hernia in an adult complicated by abdominal compartment syndrome, gastropleural fistula and pleural empyema: Report of a case. ( 24441713 )
2014
48
Minimally Invasive Vacuum-Assisted Closure Therapy With Instillation (Mini-VAC-Instill) for Pleural Empyema. ( 25049317 )
2014
49
Surgery for parapneumonic pleural empyema - What influence does the rising prevalence of multimorbidity and advanced age has on the current outcome? ( 24930000 )
2014
50
Liver abscess complicated by diaphragm perforation and pleural empyema leads to the discovery of interleukin-1 receptor-associated kinase 4 deficiency. ( 24717963 )
2014

Variations for Pleural Empyema

Expression for Pleural Empyema

Search GEO for disease gene expression data for Pleural Empyema.

Pathways for Pleural Empyema

Pathways related to Pleural Empyema according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.61 SMC2 SMC4
2 10.14 SMC2 SMC4

GO Terms for Pleural Empyema

Cellular components related to Pleural Empyema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 condensin complex GO:0000796 8.62 SMC2 SMC4

Biological processes related to Pleural Empyema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome organization GO:0051276 9.37 SMC2 SMC4
2 chromosome condensation GO:0030261 9.32 SMC2 SMC4
3 mitotic chromosome condensation GO:0007076 9.26 SMC2 SMC4
4 meiotic chromosome segregation GO:0045132 9.16 SMC2 SMC4
5 kinetochore organization GO:0051383 8.96 SMC2 SMC4
6 meiotic chromosome condensation GO:0010032 8.62 SMC2 SMC4

Sources for Pleural Empyema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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