MCID: PLR001
MIFTS: 50

Pleural Tuberculosis

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Pleural Tuberculosis

MalaCards integrated aliases for Pleural Tuberculosis:

Name: Pleural Tuberculosis 12 15 73
Tuberculous Pleurisy in Primary Progressive Tuberculosis 12
Serosal Tuberculosis of Cattle 73
Tuberculosis of Pleura 12
Tuberculous Pleuritis 12
Tuberculosis, Pleural 44
Tuberculous Pleurisy 12
Pleurisy Tuberculous 55
Pearly Disease 12

Classifications:



Summaries for Pleural Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in lymphocyte-predominant exudative pleural effusion, located in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

MalaCards based summary : Pleural Tuberculosis, also known as tuberculous pleurisy in primary progressive tuberculosis, is related to tuberculous peritonitis and extrapulmonary tuberculosis. An important gene associated with Pleural Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include pleura, testes and t cells, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Pleural Tuberculosis

Diseases related to Pleural Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 31.2 ADA IFNG TBP TNF
2 extrapulmonary tuberculosis 30.8 ADA CCL2 IFNG TBP
3 pleurisy 30.3 ADA CCL2 CXCL8 IFNG TNF
4 pulmonary tuberculosis 29.3 ADA IFNG IL18 TNF
5 peritonitis 28.7 ADA B2M CCL2 CXCL8 TNF
6 spondylarthropathy 10.8 B2M TNF
7 mercury poisoning 10.8 B2M IL18
8 aids dementia complex 10.7 B2M TNF
9 systemic onset juvenile idiopathic arthritis 10.7 IL18 TNF
10 autoimmune inner ear disease 10.7 TIMP1 TNF
11 staphylococcal toxic shock syndrome 10.6 IFNG TNF
12 autoimmune myocarditis 10.6 IFNG TNF
13 monoclonal gammopathy of uncertain significance 10.6 B2M TNF
14 inflammatory bowel disease 3 10.6 IL18 TNF
15 trichosporonosis 10.6 IFNG TNF
16 chronic beryllium disease 10.6 IFNG TNF
17 post-transplant lymphoproliferative disease 10.6 B2M TNF
18 tungiasis 10.6 CXCL8 TNF
19 streptococcal toxic-shock syndrome 10.6 CXCL8 TNF
20 microscopic colitis 10.6 IFNG TNF
21 soft tissue sarcoma 10.5 IFNG TNF
22 cytomegalovirus retinitis 10.5 IFNG TNF
23 posterior uveitis 10.5 IFNG TNF
24 trichuriasis 10.5 CXCL8 TNF
25 haemophilus influenzae 10.5 CXCL8 TNF
26 primary systemic mycosis 10.5 IFNG TNF
27 poliomyelitis 10.5 IFNG TNF
28 sapho syndrome 10.5 CXCL8 IL18
29 mycobacterium abscessus 10.5 CXCL8 TNF
30 louse-borne relapsing fever 10.5 CXCL8 TNF
31 intermediate uveitis 10.5 IFNG TNF
32 dental pulp disease 10.5 CXCL8 TNF
33 anthracosis 10.5 CCL2 TNF
34 transverse myelitis 10.5 CXCL8 TNF
35 streptococcal meningitis 10.5 ADA TNF
36 scleritis 10.5 CCL2 TNF
37 orofacial granulomatosis 10.5 IFNG TNF
38 cryptococcal meningitis 10.5 ADA IFNG
39 cryptogenic organizing pneumonia 10.5 CXCL8 TIMP1
40 listeria meningitis 10.4 ADA IL18 TNF
41 coccidiosis 10.4 IFNG TNF
42 necrotizing fasciitis 10.4 CXCL8 IL18
43 noma 10.4 CXCL8 IL18
44 cyclic neutropenia 10.4 CXCL8 IFNG
45 inner ear disease 10.4 B2M TIMP1 TNF
46 abdominal tuberculosis 10.4 ADA TBP
47 eales disease 10.4 IFNG TNF
48 lung giant cell carcinoma 10.4 CXCL8 TIMP1
49 hemorrhagic fever 10.4 IFNG TNF
50 human immunodeficiency virus infectious disease 10.4 B2M IFNG TNF

Comorbidity relations with Pleural Tuberculosis via Phenotypic Disease Network (PDN):


Deficiency Anemia Heart Disease
Pulmonary Tuberculosis

Graphical network of the top 20 diseases related to Pleural Tuberculosis:



Diseases related to Pleural Tuberculosis

Symptoms & Phenotypes for Pleural Tuberculosis

MGI Mouse Phenotypes related to Pleural Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 IL18 TBP TIMP1 TNF ADA B2M
2 growth/size/body region MP:0005378 9.56 IFNG IL18 PTBP2 TBP TIMP1 TNF
3 mortality/aging MP:0010768 9.28 IL18 PTBP2 TBP TIMP1 TNF ADA

Drugs & Therapeutics for Pleural Tuberculosis

Drugs for Pleural Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
2
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
3
Adenosine Approved, Investigational Not Applicable 58-61-7 60961
4 Anti-Inflammatory Agents Not Applicable
5 Antineoplastic Agents, Hormonal Not Applicable
6 glucocorticoids Not Applicable
7 Hormone Antagonists Not Applicable
8 Hormones Not Applicable
9 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
10 Methylprednisolone acetate Not Applicable
11 Methylprednisolone Hemisuccinate Not Applicable
12 Prednisolone acetate Not Applicable
13 Prednisolone hemisuccinate Not Applicable
14 Prednisolone phosphate Not Applicable
15 Analgesics Not Applicable
16 Anti-Arrhythmia Agents Not Applicable
17 Neurotransmitter Agents Not Applicable
18 Peripheral Nervous System Agents Not Applicable
19 Vasodilator Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy Unknown status NCT01685099
2 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Unknown status NCT00313066
3 Corticosteroids in the Treatment of Tuberculous Pleurisy Completed NCT00338793 Not Applicable prednisolone
4 Continuous Positive Airway Pressure on Tuberculosis Pleural Effusion Completed NCT00560521 Not Applicable
5 Drainage of Tuberculous Pleural Effusions Completed NCT00524147 Not Applicable
6 Reproducibility of Computed Tomography Completed NCT01616264
7 Outcome of Patients Undiagnosed Under Medical Thoracoscopy Completed NCT01356979
8 Efficiency and Safety of Pleural Biopsy Methods in the Diagnosis of Pleural Diseases Completed NCT03153501 Not Applicable
9 E-Nose: Diagnostic Tool for Pleural TB Recruiting NCT02765087 Not Applicable

Search NIH Clinical Center for Pleural Tuberculosis

Cochrane evidence based reviews: tuberculosis, pleural

Genetic Tests for Pleural Tuberculosis

Anatomical Context for Pleural Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Pleural Tuberculosis:

19
Pleura

MalaCards organs/tissues related to Pleural Tuberculosis:

41
Testes, T Cells, Neutrophil, Lung, Liver, Whole Blood

Publications for Pleural Tuberculosis

Articles related to Pleural Tuberculosis:

(show top 50) (show all 145)
# Title Authors Year
1
The neuro-endocrine-immune relationship in pulmonary and pleural tuberculosis: a better local profile in pleural fluid. ( 29471911 )
2018
2
Pleural tuberculosis: A concise clinical review. ( 29660258 )
2018
3
Pleural tuberculosis: medical thoracoscopy greatly increases the diagnostic accuracy. ( 29318136 )
2018
4
Thoracoscopic pleural biopsy improves yield of Xpert MTB/RIF for diagnosis of pleural tuberculosis. ( 29486527 )
2018
5
QuantiFERONAr-TB Gold test conversion in a psoriatic patient with pleural tuberculosis oneA year after adalimumab treatment. ( 29475466 )
2018
6
DEVELOPMENT OF A CLINICAL PREDICTION RULE FOR DIAGNOSIS OF PLEURAL TUBERCULOSIS IN PERU. ( 29408477 )
2018
7
Reactivation of peritoneal and pleural tuberculosis during hepatitis C treatment with direct-acting antivirals. ( 29665974 )
2018
8
Inhibiting HLA-G restores IFN-I^ and TNF-I+ producing T cell in pleural Tuberculosis. ( 29559123 )
2018
9
Performance of clinical prediction rules for diagnosis of pleural tuberculosis in a high-incidence setting. ( 28727272 )
2017
10
Real-time PCR assay for the diagnosis of pleural tuberculosis. ( 29021638 )
2017
11
A Rare Case of Primary Calcific Pleural Tuberculosis - A Case Report. ( 28892960 )
2017
12
Pleural Tuberculosis following Infliximab Therapy for Ankylosing Spondylitis. ( 28405137 )
2017
13
Pleural tuberculosis under rituximab therapy for anti-synthetase syndrome. ( 28784035 )
2017
14
A rare case of subcutaneous abscess with intercostal muscles involvement by pleural tuberculosis in a Malagasy young traveller. ( 28931146 )
2017
15
Challenges in pleural tuberculosis diagnosis: existing reference standards and nucleic acid tests. ( 28972418 )
2017
16
Transudative chylothorax and pleural tuberculosis in a patient with Eisenmenger syndrome: An extraordinary coincidence. ( 28869240 )
2017
17
Paradoxical results of two automated real-time PCR assays in the diagnosis of pleural tuberculosis. ( 27866961 )
2017
18
A 22-year-old man with pleural tuberculosis associated hydropneumothorax: Case report and literature review. ( 27144114 )
2016
19
Can pleural adenosine deaminase (ADA) levels in pleural tuberculosis predict the presence of pulmonary tuberculosis? A CT analysis. ( 27017482 )
2016
20
Yield of mycobacteriological study in diagnosis of pleural tuberculosis among Human immune deficiency virus-infected patients. ( 28043494 )
2016
21
Correction for Aggarwal et al., Interferon Gamma Release Assays for Diagnosis of Pleural Tuberculosis: a Systematic Review and Meta-Analysis. ( 26822772 )
2016
22
Safety and effectiveness of CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy for the treatment of pleural tuberculosis. ( 27446302 )
2016
23
Modified TB rapid test by proteinase K for rapid diagnosis of pleural tuberculosis. ( 26693840 )
2016
24
Use of Pleural Fluid Interferon-gamma Enzyme-linked Immunospot Assay in the Diagnosis of Pleural Tuberculosis. ( 27241543 )
2016
25
Clinical and Laboratory Differences between Lymphocyte- and Neutrophil-Predominant Pleural Tuberculosis. ( 27788218 )
2016
26
Status of Exudative Pleural Effusion in Adults of South Khorasan Province, Northeast Iran: Pleural Tuberculosis Tending toward Elderly. ( 27365554 )
2016
27
Pleural tuberculosis in the state of Roraima, Brazil, between 2005 and 2013: quality of diagnosis. ( 27167431 )
2016
28
Adenosine deaminase is a useful biomarker to diagnose pleural tuberculosis in low to medium prevalence settings. ( 26707067 )
2016
29
Tissue inhibitor of metalloproteinase-1 is responsible for residual pleural thickening in pleural tuberculosis. ( 25854270 )
2015
30
Pleural tuberculosis in a patient with untreated type 1 Gaucher disease. ( 26459658 )
2015
31
Interferon Gamma Release Assays for Diagnosis of Pleural Tuberculosis: a Systematic Review and Meta-Analysis. ( 25994163 )
2015
32
Pleural fluid characteristics of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis. ( 25589836 )
2015
33
The comparative value of pleural fluid adenosine deaminase and neopterin levels in diagnostic utility of pleural tuberculosis. ( 26963307 )
2015
34
Rhodotorula mucilaginosa Fungemia and Pleural Tuberculosis in an Immunocompetent Patient: An Uncommon Association. ( 26369644 )
2015
35
Rapid diagnosis of pleural tuberculosis by Xpert MTB/RIF assay using pleural biopsy and pleural fluid specimens. ( 25767518 )
2015
36
Performance of Xpert MTB/RIF Assay in Diagnosis of Pleural Tuberculosis by Use of Pleural Fluid Samples. ( 26311855 )
2015
37
Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis. ( 26436408 )
2015
38
Interleukin-27 improves the ability of adenosine deaminase to rule out tuberculous pleural effusion regardless of pleural tuberculosis prevalence. ( 25753767 )
2015
39
Profiling the T-cell receptor repertoire of patient with pleural tuberculosis by high-throughput sequencing. ( 25173045 )
2014
40
Expression of fibroblast specific protein-1 in pleural tuberculosis and its clinical biological significance. ( 24885536 )
2014
41
Pulmonary Changes of Pleural Tuberculosis: Up-to-Date CT Imaging. ( 25086249 )
2014
42
Diagnostic utility of serum and pleural levels of adenosine deaminase 1-2, and interferon-I^ in the diagnosis of pleural tuberculosis. ( 24602306 )
2014
43
Evaluation of Cepheid's Xpert MTB/Rif test on pleural fluid in the diagnosis of pleural tuberculosis in a high prevalence HIV/TB setting. ( 25051491 )
2014
44
Accuracy of polimerase chain reaction for the diagnosis of pleural tuberculosis. ( 24803060 )
2014
45
Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-I^ for the evaluation of pleural tuberculosis: a prospective cohort study. ( 24708530 )
2014
46
Role of adenosine deaminase and the influence of age on the diagnosis of pleural tuberculosis. ( 25299872 )
2014
47
Diagnostic value of pleural fluid interferon-gamma and adenosine deaminase in patients with pleural tuberculosis in Qatar. ( 23378780 )
2013
48
Pleural tuberculosis mimicking inflammatory pseudotumour. ( 23730653 )
2013
49
Performance of Xpert MTB/RIF on pleural tissue for the diagnosis of pleural tuberculosis. ( 23900990 )
2013
50
Artificial neural network models to support the diagnosis of pleural tuberculosis in adult patients. ( 23575336 )
2013

Variations for Pleural Tuberculosis

Expression for Pleural Tuberculosis

Search GEO for disease gene expression data for Pleural Tuberculosis.

Pathways for Pleural Tuberculosis

Pathways related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.52 CCL2 CXCL8 IFNG IL18 TBP TIMP1
2
Show member pathways
13.36 CCL2 CXCL8 IFNG IL18 TIMP1 TNF
3
Show member pathways
13.16 CCL2 CXCL8 IL18 TIMP1 TNF
4
Show member pathways
13.15 B2M CCL2 CXCL8 IFNG IL18 TIMP1
5
Show member pathways
12.87 CCL2 CXCL8 IFNG IL18 TNF
6
Show member pathways
12.72 B2M CXCL8 IFNG IL18 TNF
7
Show member pathways
12.64 CXCL8 IFNG IL18 TNF
8
Show member pathways
12.6 CCL2 CXCL8 IFNG IL18 TBP TNF
9
Show member pathways
12.51 CXCL8 IFNG IL18 TNF
10 12.44 B2M CCL2 IFNG TNF
11
Show member pathways
12.41 CCL2 IFNG IL18 TIMP1 TNF
12
Show member pathways
12.18 CCL2 CXCL8 IFNG TNF
13
Show member pathways
12.15 CXCL8 IFNG TNF
14
Show member pathways
12.14 IFNG IL18 TNF
15 12.12 IFNG IL18 TNF
16
Show member pathways
12.11 CXCL8 IL18 TNF
17
Show member pathways
12.07 CXCL8 IFNG TNF
18 11.98 CCL2 IFNG TNF
19
Show member pathways
11.93 CCL2 CXCL8 IFNG IL18 TIMP1
20
Show member pathways
11.88 B2M IFNG IL18
21 11.84 CCL2 CXCL8 IFNG TNF
22 11.81 CCL2 CXCL8 TNF
23 11.79 CXCL8 IFNG TNF
24 11.78 CCL2 CXCL8 IL18 TIMP1 TNF
25 11.73 CXCL8 IFNG IL18
26 11.69 CXCL8 IFNG TBP
27 11.68 IFNG IL18 TNF
28
Show member pathways
11.65 CXCL8 IFNG TNF
29
Show member pathways
11.55 CXCL8 IFNG TNF
30
Show member pathways
11.53 B2M IFNG TNF
31 11.51 CCL2 CXCL8 IFNG IL18 TNF
32 11.5 CCL2 CXCL8 TIMP1 TNF
33 11.47 CXCL8 IL18 TNF
34 11.35 CCL2 IFNG IL18 TNF
35 11.26 IFNG IL18 TNF
36 11.19 IFNG IL18 TNF
37 11.18 IFNG TNF
38 11.14 IFNG IL18
39 11.06 CXCL8 TNF
40 11.04 CCL2 CXCL8 IL18 TIMP1 TNF
41 11.02 IL18 TNF
42 10.97 IFNG IL18
43 10.96 CCL2 IFNG IL18 TIMP1
44 10.94 CCL2 TIMP1
45 10.94 CXCL8 TNF
46 10.86 CCL2 TNF
47 10.71 CCL2 CXCL8 IFNG IL18 TNF

GO Terms for Pleural Tuberculosis

Cellular components related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 B2M CCL2 CXCL8 IFNG IL18 TIMP1
2 extracellular space GO:0005615 9.23 ADA B2M CCL2 CXCL8 IFNG IL18

Biological processes related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.83 CCL2 CXCL8 IL18 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.72 CCL2 CXCL8 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.65 CCL2 CXCL8 IL18 TIMP1 TNF
4 cellular response to organic cyclic compound GO:0071407 9.63 CCL2 IL18 TNF
5 humoral immune response GO:0006959 9.61 CCL2 IFNG TNF
6 cellular response to fibroblast growth factor stimulus GO:0044344 9.6 CCL2 CXCL8
7 protein import into nucleus, translocation GO:0000060 9.59 IFNG TNF
8 positive regulation of T cell activation GO:0050870 9.58 ADA CCL2
9 positive regulation of protein complex assembly GO:0031334 9.58 IFNG TNF
10 negative regulation of myoblast differentiation GO:0045662 9.57 IL18 TNF
11 positive regulation of osteoclast differentiation GO:0045672 9.56 IFNG TNF
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.54 IFNG TNF
13 response to molecule of bacterial origin GO:0002237 9.51 B2M CXCL8
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.5 CCL2 IL18 TNF
15 PERK-mediated unfolded protein response GO:0036499 9.49 CCL2 CXCL8
16 neutrophil activation GO:0042119 9.48 CXCL8 IL18
17 immune response GO:0006955 9.43 B2M CCL2 CXCL8 IFNG IL18 TNF
18 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IFNG TNF
19 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
20 embryonic digestive tract development GO:0048566 9.33 ADA CXCL8 TNF
21 regulation of signaling receptor activity GO:0010469 9.1 CCL2 CXCL8 IFNG IL18 TIMP1 TNF

Molecular functions related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IFNG IL18 TIMP1 TNF

Sources for Pleural Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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