MCID: PLR001
MIFTS: 52

Pleural Tuberculosis

Categories: Immune diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Pleural Tuberculosis

MalaCards integrated aliases for Pleural Tuberculosis:

Name: Pleural Tuberculosis 12 15 17 74
Tuberculous Pleurisy in Primary Progressive Tuberculosis 12
Serosal Tuberculosis of Cattle 74
Tuberculosis of Pleura 12
Tuberculous Pleuritis 12
Tuberculosis, Pleural 45
Tuberculous Pleurisy 12
Pleurisy Tuberculous 56
Pearly Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:106
ICD9CM 36 010.1 012.0 012.00
MeSH 45 D014396
NCIt 51 C26898
SNOMED-CT 69 36379004 68706009
ICD10 34 A15.6 A16.5

Summaries for Pleural Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in lymphocyte-predominant exudative pleural effusion, located in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

MalaCards based summary : Pleural Tuberculosis, also known as tuberculous pleurisy in primary progressive tuberculosis, is related to tuberculous peritonitis and extrapulmonary tuberculosis. An important gene associated with Pleural Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and t cells, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and growth/size/body region

Related Diseases for Pleural Tuberculosis

Diseases related to Pleural Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 31.6 ADA IFNG TBP TNF
2 extrapulmonary tuberculosis 31.4 ADA CCL2 IFNG TBP
3 pleurisy 31.2 ADA CCL2 CXCL8 IFNG TNF
4 mycobacterium tuberculosis 1 30.2 ADA IFNG IL18 TNF
5 human immunodeficiency virus infectious disease 30.2 B2M IFNG TNF
6 crohn's colitis 30.1 CXCL8 IFNG TNF
7 pneumonia 30.0 CCL2 CXCL8 TNF
8 pleural disease 29.8 ADA TBP TNF
9 lymphadenitis 29.8 CXCL8 IFNG IL18 TNF
10 tuberculous meningitis 29.7 ADA CCL2 CXCL8 TNF
11 pulmonary tuberculosis 29.6 ADA IFNG IL18 TNF
12 meningitis 29.4 ADA CCL2 CXCL8 IFNG TNF
13 arthritis 29.3 CCL2 CXCL8 IFNG IL18 TNF
14 rheumatoid arthritis 28.5 CCL2 CXCL8 IFNG IL18 IL2RA TIMP1
15 pneumothorax 10.4
16 mercury poisoning 10.4 B2M IL18
17 lichen disease 10.4 IFNG TNF
18 aids dementia complex 10.4 B2M TNF
19 systemic onset juvenile idiopathic arthritis 10.3 IL18 TNF
20 autoimmune inner ear disease 10.3 TIMP1 TNF
21 staphylococcal toxic shock syndrome 10.3 IFNG TNF
22 autoimmune myocarditis 10.3 IFNG TNF
23 melanoma metastasis 10.3 IL18 TNF
24 exudative glomerulonephritis 10.3 CXCL8 TNF
25 trichosporonosis 10.3 IFNG TNF
26 chronic beryllium disease 10.3 IFNG TNF
27 scleritis 10.3 IFNG TNF
28 inflammatory bowel disease 3 10.3 IL18 TNF
29 tungiasis 10.3 CXCL8 TNF
30 streptococcal toxic-shock syndrome 10.3 CXCL8 TNF
31 microscopic colitis 10.3 IFNG TNF
32 central nervous system vasculitis 10.2 IFNG TNF
33 cardiac sarcoidosis 10.2 CXCL8 TNF
34 haemophilus influenzae 10.2 CXCL8 TNF
35 opisthorchiasis 10.2 CXCL8 TNF
36 soft tissue sarcoma 10.2 IFNG TNF
37 oligoarticular juvenile idiopathic arthritis 10.2 IL2RA TNF
38 sapho syndrome 10.2 CXCL8 IL18
39 post-transplant lymphoproliferative disease 10.2 B2M TNF
40 pyelitis 10.2 B2M CXCL8
41 mycobacterium abscessus 10.2 CXCL8 TNF
42 louse-borne relapsing fever 10.2 CXCL8 TNF
43 anthracosis 10.2 CCL2 TNF
44 cryptogenic organizing pneumonia 10.2 CXCL8 TIMP1
45 noma 10.2 CXCL8 IL18
46 listeria meningitis 10.2 ADA IL18 TNF
47 endometrial disease 10.2 CXCL8 TNF
48 dental pulp disease 10.2 CXCL8 TNF
49 congenital cytomegalovirus 10.2 CCL2 TNF
50 periodontosis 10.2 CXCL8 TNF

Comorbidity relations with Pleural Tuberculosis via Phenotypic Disease Network (PDN):


Deficiency Anemia Heart Disease
Pulmonary Tuberculosis

Graphical network of the top 20 diseases related to Pleural Tuberculosis:



Diseases related to Pleural Tuberculosis

Symptoms & Phenotypes for Pleural Tuberculosis

GenomeRNAi Phenotypes related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.8 CXCL8 IL2RA TNF

MGI Mouse Phenotypes related to Pleural Tuberculosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.97 ADA B2M IFNG IL18 IL2RA PTBP2
2 cardiovascular system MP:0005385 9.95 ADA B2M IFNG IL18 TBP TIMP1
3 homeostasis/metabolism MP:0005376 9.91 ADA B2M IFNG IL18 IL2RA PTBP2
4 digestive/alimentary MP:0005381 9.85 ADA B2M IFNG IL18 IL2RA TNF
5 immune system MP:0005387 9.76 ADA B2M CCL2 IFNG IL18 IL2RA
6 mortality/aging MP:0010768 9.61 ADA B2M IFNG IL18 IL2RA PTBP2
7 respiratory system MP:0005388 9.1 ADA IFNG IL2RA PTBP2 TIMP1 TNF

Drugs & Therapeutics for Pleural Tuberculosis

Drugs for Pleural Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
2
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
3
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
4
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
5
Adenosine Approved, Investigational Not Applicable 58-61-7 60961
6
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
7 Antineoplastic Agents, Hormonal Not Applicable
8 Anti-Inflammatory Agents Not Applicable
9 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
10 glucocorticoids Not Applicable
11 Methylprednisolone Acetate Not Applicable
12 Hormones Not Applicable
13 Prednisolone acetate Not Applicable
14 Hormone Antagonists Not Applicable
15 Peripheral Nervous System Agents Not Applicable
16 Neurotransmitter Agents Not Applicable
17 Analgesics Not Applicable
18 Anti-Arrhythmia Agents Not Applicable
19 Vasodilator Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy Unknown status NCT01685099
2 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Unknown status NCT00313066
3 Corticosteroids in the Treatment of Tuberculous Pleurisy Completed NCT00338793 Not Applicable prednisolone
4 Continuous Positive Airway Pressure on Tuberculosis Pleural Effusion Completed NCT00560521 Not Applicable
5 Drainage of Tuberculous Pleural Effusions Completed NCT00524147 Not Applicable
6 Reproducibility of Computed Tomography Completed NCT01616264
7 Outcome of Patients Undiagnosed Under Medical Thoracoscopy Completed NCT01356979
8 Efficiency and Safety of Pleural Biopsy Methods in the Diagnosis of Pleural Diseases Completed NCT03153501 Not Applicable
9 E-Nose: Diagnostic Tool for Pleural TB Recruiting NCT02765087 Not Applicable

Search NIH Clinical Center for Pleural Tuberculosis

Cochrane evidence based reviews: tuberculosis, pleural

Genetic Tests for Pleural Tuberculosis

Anatomical Context for Pleural Tuberculosis

MalaCards organs/tissues related to Pleural Tuberculosis:

42
Testes, Bone, T Cells, Neutrophil, Whole Blood, Skin, Tonsil

The Foundational Model of Anatomy Ontology organs/tissues related to Pleural Tuberculosis:

20
Pleura

Publications for Pleural Tuberculosis

Articles related to Pleural Tuberculosis:

(show top 50) (show all 158)
# Title Authors Year
1
A novel aptamer-based test for the rapid and accurate diagnosis of pleural tuberculosis. ( 30352198 )
2019
2
Epidemiology and diagnosis of pleural tuberculosis in a low incidence country with high rate of immigrant population: A retrospective study. ( 30449728 )
2019
3
Score for Differentiating Pleural Tuberculosis from Malignant Effusion. ( 30813590 )
2019
4
Isoniazid-Induced Acute Psychosis in a Patient with Pleural Tuberculosis. ( 30906613 )
2019
5
Reactivation of peritoneal and pleural tuberculosis during hepatitis C treatment with direct-acting antivirals. ( 29665974 )
2019
6
The role of thoracoscopic biopsies in the diagnosis of pleural tuberculosis. ( 31061789 )
2019
7
Pleural tuberculosis under rituximab therapy for anti-synthetase syndrome. ( 28784035 )
2018
8
Pleural tuberculosis: medical thoracoscopy greatly increases the diagnostic accuracy. ( 29318136 )
2018
9
Development of a clinical prediction rule for the diagnosis of pleural tuberculosis in Peru. ( 29408477 )
2018
10
The neuro-endocrine-immune relationship in pulmonary and pleural tuberculosis: a better local profile in pleural fluid. ( 29471911 )
2018
11
QuantiFERON®-TB Gold test conversion in a psoriatic patient with pleural tuberculosis one year after adalimumab treatment. ( 29475466 )
2018
12
Thoracoscopic pleural biopsy improves yield of Xpert MTB/RIF for diagnosis of pleural tuberculosis. ( 29486527 )
2018
13
Inhibiting HLA-G restores IFN-γ and TNF-α producing T cell in pleural Tuberculosis. ( 29559123 )
2018
14
Pleural tuberculosis: A concise clinical review. ( 29660258 )
2018
15
Characteristics and factors associated with treatment delay in pleural tuberculosis. ( 30053223 )
2018
16
Diagnostic Potential of Circulating Biomarkers in Adenosine Deaminase Diagnosed Pleural Tuberculosis Cases. ( 30072834 )
2018
17
Application of Venn's diagram in the diagnosis of pleural tuberculosis using IFN-γ, IP-10 and adenosine deaminase. ( 30148839 )
2018
18
Pediatric pleural tuberculosis. ( 30198507 )
2018
19
Pleural tuberculosis: a key differential diagnosis for pleural thickening, even without obvious risk factors for tuberculosis in a low incidence setting. ( 30368474 )
2018
20
Usefulness of Adenosine Deaminase Assay in Diagnosis of Patients with HIV Infection and Pleural Tuberculosis. ( 30428535 )
2018
21
Paradoxical results of two automated real-time PCR assays in the diagnosis of pleural tuberculosis. ( 27866961 )
2017
22
Pleural Tuberculosis following Infliximab Therapy for Ankylosing Spondylitis. ( 28405137 )
2017
23
Performance of clinical prediction rules for diagnosis of pleural tuberculosis in a high-incidence setting. ( 28727272 )
2017
24
A Rare Case of Primary Calcific Pleural Tuberculosis - A Case Report. ( 28892960 )
2017
25
A rare case of subcutaneous abscess with intercostal muscles involvement by pleural tuberculosis in a Malagasy young traveller. ( 28931146 )
2017
26
Challenges in pleural tuberculosis diagnosis: existing reference standards and nucleic acid tests. ( 28972418 )
2017
27
Real-time PCR assay for the diagnosis of pleural tuberculosis. ( 29021638 )
2017
28
Transudative chylothorax and pleural tuberculosis in a patient with Eisenmenger syndrome: An extraordinary coincidence. ( 28869240 )
2017
29
Use of Pleural Fluid Interferon-gamma Enzyme-linked Immunospot Assay in the Diagnosis of Pleural Tuberculosis. ( 27241543 )
2016
30
Status of Exudative Pleural Effusion in Adults of South Khorasan Province, Northeast Iran: Pleural Tuberculosis Tending toward Elderly. ( 27365554 )
2016
31
Safety and effectiveness of CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy for the treatment of pleural tuberculosis. ( 27446302 )
2016
32
Clinical and Laboratory Differences between Lymphocyte- and Neutrophil-Predominant Pleural Tuberculosis. ( 27788218 )
2016
33
Yield of mycobacteriological study in diagnosis of pleural tuberculosis among Human immune deficiency virus-infected patients. ( 28043494 )
2016
34
Paradoxical Deterioration During Anti-Tuberculous Therapy in Non-HIV-Infected Patients with Pleural Tuberculosis: A Pragmatic Approach. ( 30755892 )
2016
35
Can pleural adenosine deaminase (ADA) levels in pleural tuberculosis predict the presence of pulmonary tuberculosis? A CT analysis. ( 27017482 )
2016
36
A 22-year-old man with pleural tuberculosis associated hydropneumothorax: Case report and literature review. ( 27144114 )
2016
37
Pleural tuberculosis in the state of Roraima, Brazil, between 2005 and 2013: quality of diagnosis. ( 27167431 )
2016
38
Correction for Aggarwal et al., Interferon Gamma Release Assays for Diagnosis of Pleural Tuberculosis: a Systematic Review and Meta-Analysis. ( 26822772 )
2016
39
Adenosine deaminase is a useful biomarker to diagnose pleural tuberculosis in low to medium prevalence settings. ( 26707067 )
2016
40
Modified TB rapid test by proteinase K for rapid diagnosis of pleural tuberculosis. ( 26693840 )
2016
41
Pleural tuberculosis in a patient with untreated type 1 Gaucher disease. ( 26459658 )
2016
42
Rhodotorula mucilaginosa Fungemia and Pleural Tuberculosis in an Immunocompetent Patient: An Uncommon Association. ( 26369644 )
2016
43
Pleural fluid characteristics of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis. ( 25589836 )
2015
44
The comparative value of pleural fluid adenosine deaminase and neopterin levels in diagnostic utility of pleural tuberculosis. ( 26963307 )
2015
45
Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis. ( 26436408 )
2015
46
Performance of Xpert MTB/RIF Assay in Diagnosis of Pleural Tuberculosis by Use of Pleural Fluid Samples. ( 26311855 )
2015
47
Interferon Gamma Release Assays for Diagnosis of Pleural Tuberculosis: a Systematic Review and Meta-Analysis. ( 25994163 )
2015
48
Tissue inhibitor of metalloproteinase-1 is responsible for residual pleural thickening in pleural tuberculosis. ( 25854270 )
2015
49
Rapid diagnosis of pleural tuberculosis by Xpert MTB/RIF assay using pleural biopsy and pleural fluid specimens. ( 25767518 )
2015
50
Interleukin-27 improves the ability of adenosine deaminase to rule out tuberculous pleural effusion regardless of pleural tuberculosis prevalence. ( 25753767 )
2015

Variations for Pleural Tuberculosis

Expression for Pleural Tuberculosis

Search GEO for disease gene expression data for Pleural Tuberculosis.

Pathways for Pleural Tuberculosis

Pathways related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 B2M CCL2 CXCL8 IFNG IL18 IL2RA
2
Show member pathways
13.55 CCL2 CXCL8 IFNG IL18 IL2RA TBP
3
Show member pathways
13.41 CCL2 CXCL8 IFNG IL18 IL2RA TIMP1
4
Show member pathways
13.29 CCL2 CXCL8 IL18 IL2RA TIMP1 TNF
5
Show member pathways
13.19 CCL2 CXCL8 IL18 IL2RA TIMP1 TNF
6
Show member pathways
13.17 B2M CCL2 CXCL8 IFNG IL18 IL2RA
7
Show member pathways
12.99 CCL2 CXCL8 IFNG IL18 TNF
8
Show member pathways
12.77 B2M CXCL8 IFNG IL18 IL2RA TNF
9
Show member pathways
12.66 CXCL8 IFNG IL18 TNF
10
Show member pathways
12.54 IFNG IL18 IL2RA TNF
11
Show member pathways
12.52 CCL2 IFNG IL18 TIMP1 TNF
12
Show member pathways
12.51 IFNG IL18 IL2RA TNF
13 12.49 B2M CCL2 IFNG IL2RA TNF
14
Show member pathways
12.26 CCL2 CXCL8 IFNG TNF
15 12.14 IFNG IL18 TNF
16
Show member pathways
12.13 CXCL8 IL18 TNF
17
Show member pathways
12.1 CXCL8 IFNG TNF
18
Show member pathways
12.05 CXCL8 IFNG IL18 IL2RA TIMP1 TNF
19 12.01 CCL2 IFNG TNF
20
Show member pathways
11.97 IFNG IL18 TNF
21 11.96 CCL2 CXCL8 IFNG TNF
22 11.92 IFNG IL2RA TNF
23
Show member pathways
11.92 B2M IFNG IL18 IL2RA
24
Show member pathways
11.89 CCL2 CXCL8 IFNG IL18 IL2RA TIMP1
25 11.84 CCL2 CXCL8 TNF
26 11.82 CXCL8 IFNG TNF
27 11.78 CCL2 CXCL8 IL18 TIMP1 TNF
28 11.77 CXCL8 IFNG IL18
29 11.75 IFNG IL18 IL2RA TNF
30 11.74 CXCL8 IFNG TBP
31
Show member pathways
11.72 CXCL8 IFNG IL2RA TNF
32 11.68 CCL2 IFNG IL18 TNF
33
Show member pathways
11.62 CXCL8 IFNG TNF
34 11.61 CCL2 CXCL8 TIMP1 TNF
35
Show member pathways
11.58 B2M IFNG IL2RA TNF
36 11.54 CXCL8 IL18 TNF
37 11.51 CCL2 CXCL8 IFNG IL18 TNF
38 11.42 CCL2 IFNG IL18 TNF
39 11.36 IFNG IL18 TNF
40 11.29 IFNG IL18 TNF
41 11.22 IFNG IL18 IL2RA
42 11.18 IFNG TNF
43
Show member pathways
11.18 IFNG IL2RA
44 11.11 CCL2 CXCL8 IL18 TBP TNF
45 11.09 CXCL8 TNF
46 11.05 IL18 TNF
47 11.04 CCL2 CXCL8 IL18 TIMP1 TNF
48 11 IFNG IL18
49 10.97 CCL2 TIMP1
50 10.97 CXCL8 TNF

GO Terms for Pleural Tuberculosis

Cellular components related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 B2M CCL2 CXCL8 IFNG IL18 TIMP1
2 external side of plasma membrane GO:0009897 9.26 ADA B2M IL2RA TNF
3 extracellular space GO:0005615 9.23 ADA B2M CCL2 CXCL8 IFNG IL18

Biological processes related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 CCL2 CXCL8 IL18 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.77 CCL2 CXCL8 TNF
3 MAPK cascade GO:0000165 9.73 CCL2 IL18 IL2RA TNF
4 cellular response to organic cyclic compound GO:0071407 9.67 CCL2 IL18 TNF
5 humoral immune response GO:0006959 9.63 CCL2 IFNG TNF
6 regulation of signaling receptor activity GO:0010469 9.63 CCL2 CXCL8 IFNG IL18 TIMP1 TNF
7 positive regulation of activated T cell proliferation GO:0042104 9.62 IL18 IL2RA
8 negative regulation of myoblast differentiation GO:0045662 9.61 IL18 TNF
9 positive regulation of protein complex assembly GO:0031334 9.61 IFNG TNF
10 positive regulation of T cell activation GO:0050870 9.6 ADA CCL2
11 positive regulation of osteoclast differentiation GO:0045672 9.58 IFNG TNF
12 positive regulation of T cell differentiation GO:0045582 9.58 ADA IL2RA
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 IFNG TNF
14 regulation of regulatory T cell differentiation GO:0045589 9.56 IFNG IL2RA
15 PERK-mediated unfolded protein response GO:0036499 9.54 CCL2 CXCL8
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 CCL2 IL18 TNF
17 response to molecule of bacterial origin GO:0002237 9.52 B2M CXCL8
18 neutrophil activation GO:0042119 9.51 CXCL8 IL18
19 positive regulation of neuroinflammatory response GO:0150078 9.48 IL18 TNF
20 embryonic digestive tract development GO:0048566 9.43 ADA CXCL8 TNF
21 cytokine-mediated signaling pathway GO:0019221 9.43 CCL2 CXCL8 IL18 IL2RA TIMP1 TNF
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IFNG TNF
23 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
24 immune response GO:0006955 9.17 B2M CCL2 CXCL8 IFNG IL18 IL2RA

Molecular functions related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IFNG IL18 TIMP1 TNF

Sources for Pleural Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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