MCID: PLR001
MIFTS: 47

Pleural Tuberculosis

Categories: Immune diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Pleural Tuberculosis

MalaCards integrated aliases for Pleural Tuberculosis:

Name: Pleural Tuberculosis 12 15 73
Tuberculous Pleurisy in Primary Progressive Tuberculosis 12
Serosal Tuberculosis of Cattle 73
Tuberculosis of Pleura 12
Tuberculous Pleuritis 12
Tuberculosis, Pleural 44
Tuberculous Pleurisy 12
Pleurisy Tuberculous 55
Pearly Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:106
ICD10 33 A15.6 A16.5
ICD9CM 35 010.1 012.0 012.00
MeSH 44 D014396
NCIt 50 C26898
SNOMED-CT 68 36379004 68706009

Summaries for Pleural Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in lymphocyte-predominant exudative pleural effusion, located in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

MalaCards based summary : Pleural Tuberculosis, also known as tuberculous pleurisy in primary progressive tuberculosis, is related to tuberculous peritonitis and extrapulmonary tuberculosis. An important gene associated with Pleural Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Methylprednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and skin, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Pleural Tuberculosis

Diseases related to Pleural Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 31.8 ADA IFNG TBP TNF
2 extrapulmonary tuberculosis 31.7 ADA CCL2 IFNG TBP
3 pleurisy 31.3 ADA CCL2 CXCL8 IFNG TNF
4 human immunodeficiency virus infectious disease 30.1 TNF IFNG B2M
5 mycobacterium tuberculosis 1 30.0 ADA IFNG IL18 TNF
6 pleural disease 30.0 TNF TBP ADA
7 pneumonia 29.9 TNF CXCL8 CCL2
8 lymphadenitis 29.8 CXCL8 IFNG IL18 TNF
9 tuberculous meningitis 29.8 ADA CCL2 CXCL8 TNF
10 viral infectious disease 29.6 TNF IFNG CXCL8
11 pericardial tuberculosis 29.6 ADA IFNG TBP
12 pulmonary tuberculosis 29.6 ADA IFNG IL18 TNF
13 meningitis 29.5 ADA CCL2 CXCL8 IFNG TNF
14 arthritis 29.5 CCL2 CXCL8 IFNG IL18 TNF
15 rheumatoid arthritis 29.3 CCL2 CXCL8 IFNG IL18 TIMP1 TNF
16 pneumothorax 10.4
17 mercury poisoning 10.2 IL18 B2M
18 aids dementia complex 10.2 TNF B2M
19 autoimmune inner ear disease 10.2 TNF TIMP1
20 staphylococcal toxic shock syndrome 10.2 TNF IFNG
21 autoimmune myocarditis 10.2 TNF IFNG
22 chronic beryllium disease 10.2 TNF IFNG
23 trichosporonosis 10.2 TNF IFNG
24 exudative glomerulonephritis 10.2 TNF CXCL8
25 chronic graft versus host disease 10.2 TNF IFNG
26 tungiasis 10.2 TNF CXCL8
27 streptococcal toxic-shock syndrome 10.2 TNF CXCL8
28 post-transplant lymphoproliferative disease 10.2 TNF B2M
29 inflammatory bowel disease 3 10.2 TNF IL18
30 central nervous system vasculitis 10.2 TNF IFNG
31 soft tissue sarcoma 10.2 TNF IFNG
32 trichuriasis 10.2 TNF CXCL8
33 haemophilus influenzae 10.2 TNF CXCL8
34 opisthorchiasis 10.2 TNF CXCL8
35 pyelitis 10.2 CXCL8 B2M
36 sapho syndrome 10.2 IL18 CXCL8
37 orofacial granulomatosis 10.2 TNF IFNG
38 mycobacterium abscessus 10.2 TNF CXCL8
39 intermediate uveitis 10.2 TNF IFNG
40 louse-borne relapsing fever 10.2 TNF CXCL8
41 periodontosis 10.2 TNF CXCL8
42 dental pulp disease 10.2 TNF CXCL8
43 endometrial disease 10.2 TNF CXCL8
44 eales disease 10.2 TNF IFNG
45 poliomyelitis 10.1 TNF IFNG
46 cryptogenic organizing pneumonia 10.1 TIMP1 CXCL8
47 anthracosis 10.1 TNF CCL2
48 transverse myelitis 10.1 TNF CXCL8
49 noma 10.1 IL18 CXCL8
50 congenital cytomegalovirus 10.1 TNF CCL2

Comorbidity relations with Pleural Tuberculosis via Phenotypic Disease Network (PDN):


Deficiency Anemia Heart Disease
Pulmonary Tuberculosis

Graphical network of the top 20 diseases related to Pleural Tuberculosis:



Diseases related to Pleural Tuberculosis

Symptoms & Phenotypes for Pleural Tuberculosis

MGI Mouse Phenotypes related to Pleural Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ADA B2M IFNG IL18 TBP TIMP1
2 growth/size/body region MP:0005378 9.56 ADA B2M IFNG IL18 PTBP2 TBP
3 mortality/aging MP:0010768 9.28 ADA B2M BRSK2 IFNG IL18 PTBP2

Drugs & Therapeutics for Pleural Tuberculosis

Drugs for Pleural Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
2
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
3
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
4
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
5
Adenosine Approved, Investigational Not Applicable 58-61-7 60961
6
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
7 Antineoplastic Agents, Hormonal Not Applicable
8 Anti-Inflammatory Agents Not Applicable
9 Hormones Not Applicable
10 Hormone Antagonists Not Applicable
11 Prednisolone acetate Not Applicable
12 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
13 Methylprednisolone acetate Not Applicable
14 glucocorticoids Not Applicable
15 Neurotransmitter Agents Not Applicable
16 Vasodilator Agents Not Applicable
17 Anti-Arrhythmia Agents Not Applicable
18 Peripheral Nervous System Agents Not Applicable
19 Analgesics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy Unknown status NCT01685099
2 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Unknown status NCT00313066
3 Corticosteroids in the Treatment of Tuberculous Pleurisy Completed NCT00338793 Not Applicable prednisolone
4 Continuous Positive Airway Pressure on Tuberculosis Pleural Effusion Completed NCT00560521 Not Applicable
5 Drainage of Tuberculous Pleural Effusions Completed NCT00524147 Not Applicable
6 Reproducibility of Computed Tomography Completed NCT01616264
7 Outcome of Patients Undiagnosed Under Medical Thoracoscopy Completed NCT01356979
8 Efficiency and Safety of Pleural Biopsy Methods in the Diagnosis of Pleural Diseases Completed NCT03153501 Not Applicable
9 E-Nose: Diagnostic Tool for Pleural TB Recruiting NCT02765087 Not Applicable

Search NIH Clinical Center for Pleural Tuberculosis

Cochrane evidence based reviews: tuberculosis, pleural

Genetic Tests for Pleural Tuberculosis

Anatomical Context for Pleural Tuberculosis

MalaCards organs/tissues related to Pleural Tuberculosis:

41
Testes, Lung, Skin, Kidney, Bone, Heart, Tonsil

The Foundational Model of Anatomy Ontology organs/tissues related to Pleural Tuberculosis:

19
Pleura

Publications for Pleural Tuberculosis

Articles related to Pleural Tuberculosis:

(show top 50) (show all 155)
# Title Authors Year
1
A novel aptamer-based test for the rapid and accurate diagnosis of pleural tuberculosis. ( 30352198 )
2019
2
Epidemiology and diagnosis of pleural tuberculosis in a low incidence country with high rate of immigrant population: A retrospective study. ( 30449728 )
2019
3
The neuro-endocrine-immune relationship in pulmonary and pleural tuberculosis: a better local profile in pleural fluid. ( 29471911 )
2018
4
Pleural tuberculosis: A concise clinical review. ( 29660258 )
2018
5
Pleural tuberculosis: medical thoracoscopy greatly increases the diagnostic accuracy. ( 29318136 )
2018
6
Thoracoscopic pleural biopsy improves yield of Xpert MTB/RIF for diagnosis of pleural tuberculosis. ( 29486527 )
2018
7
QuantiFERONAr-TB Gold test conversion in a psoriatic patient with pleural tuberculosis oneA year after adalimumab treatment. ( 29475466 )
2018
8
DEVELOPMENT OF A CLINICAL PREDICTION RULE FOR DIAGNOSIS OF PLEURAL TUBERCULOSIS IN PERU. ( 29408477 )
2018
9
Reactivation of peritoneal and pleural tuberculosis during hepatitis C treatment with direct-acting antivirals. ( 29665974 )
2018
10
Inhibiting HLA-G restores IFN-I^ and TNF-I+ producing T cell in pleural Tuberculosis. ( 29559123 )
2018
11
Characteristics and factors associated with treatment delay in pleural tuberculosis. ( 30053223 )
2018
12
Diagnostic Potential of Circulating Biomarkers in Adenosine Deaminase Diagnosed Pleural Tuberculosis Cases. ( 30072834 )
2018
13
Application of Venn's diagram in the diagnosis of pleural tuberculosis using IFN-γ, IP-10 and adenosine deaminase. ( 30148839 )
2018
14
Pediatric pleural tuberculosis. ( 30198507 )
2018
15
Pleural tuberculosis: a key differential diagnosis for pleural thickening, even without obvious risk factors for tuberculosis in a low incidence setting. ( 30368474 )
2018
16
Usefulness of Adenosine Deaminase Assay in Diagnosis of Patients with HIV Infection and Pleural Tuberculosis. ( 30428535 )
2018
17
Performance of clinical prediction rules for diagnosis of pleural tuberculosis in a high-incidence setting. ( 28727272 )
2017
18
Real-time PCR assay for the diagnosis of pleural tuberculosis. ( 29021638 )
2017
19
A Rare Case of Primary Calcific Pleural Tuberculosis - A Case Report. ( 28892960 )
2017
20
Pleural Tuberculosis following Infliximab Therapy for Ankylosing Spondylitis. ( 28405137 )
2017
21
Pleural tuberculosis under rituximab therapy for anti-synthetase syndrome. ( 28784035 )
2017
22
A rare case of subcutaneous abscess with intercostal muscles involvement by pleural tuberculosis in a Malagasy young traveller. ( 28931146 )
2017
23
Challenges in pleural tuberculosis diagnosis: existing reference standards and nucleic acid tests. ( 28972418 )
2017
24
Transudative chylothorax and pleural tuberculosis in a patient with Eisenmenger syndrome: An extraordinary coincidence. ( 28869240 )
2017
25
Paradoxical results of two automated real-time PCR assays in the diagnosis of pleural tuberculosis. ( 27866961 )
2017
26
A 22-year-old man with pleural tuberculosis associated hydropneumothorax: Case report and literature review. ( 27144114 )
2016
27
Can pleural adenosine deaminase (ADA) levels in pleural tuberculosis predict the presence of pulmonary tuberculosis? A CT analysis. ( 27017482 )
2016
28
Yield of mycobacteriological study in diagnosis of pleural tuberculosis among Human immune deficiency virus-infected patients. ( 28043494 )
2016
29
Correction for Aggarwal et al., Interferon Gamma Release Assays for Diagnosis of Pleural Tuberculosis: a Systematic Review and Meta-Analysis. ( 26822772 )
2016
30
Safety and effectiveness of CT-guided percutaneous pulmonary paracentesis and tuberculoma perfusing chemotherapy for the treatment of pleural tuberculosis. ( 27446302 )
2016
31
Modified TB rapid test by proteinase K for rapid diagnosis of pleural tuberculosis. ( 26693840 )
2016
32
Use of Pleural Fluid Interferon-gamma Enzyme-linked Immunospot Assay in the Diagnosis of Pleural Tuberculosis. ( 27241543 )
2016
33
Clinical and Laboratory Differences between Lymphocyte- and Neutrophil-Predominant Pleural Tuberculosis. ( 27788218 )
2016
34
Status of Exudative Pleural Effusion in Adults of South Khorasan Province, Northeast Iran: Pleural Tuberculosis Tending toward Elderly. ( 27365554 )
2016
35
Pleural tuberculosis in the state of Roraima, Brazil, between 2005 and 2013: quality of diagnosis. ( 27167431 )
2016
36
Adenosine deaminase is a useful biomarker to diagnose pleural tuberculosis in low to medium prevalence settings. ( 26707067 )
2016
37
Tissue inhibitor of metalloproteinase-1 is responsible for residual pleural thickening in pleural tuberculosis. ( 25854270 )
2015
38
Pleural tuberculosis in a patient with untreated type 1 Gaucher disease. ( 26459658 )
2015
39
Interferon Gamma Release Assays for Diagnosis of Pleural Tuberculosis: a Systematic Review and Meta-Analysis. ( 25994163 )
2015
40
Pleural fluid characteristics of pleuropulmonary paragonimiasis masquerading as pleural tuberculosis. ( 25589836 )
2015
41
The comparative value of pleural fluid adenosine deaminase and neopterin levels in diagnostic utility of pleural tuberculosis. ( 26963307 )
2015
42
Rhodotorula mucilaginosa Fungemia and Pleural Tuberculosis in an Immunocompetent Patient: An Uncommon Association. ( 26369644 )
2015
43
Rapid diagnosis of pleural tuberculosis by Xpert MTB/RIF assay using pleural biopsy and pleural fluid specimens. ( 25767518 )
2015
44
Performance of Xpert MTB/RIF Assay in Diagnosis of Pleural Tuberculosis by Use of Pleural Fluid Samples. ( 26311855 )
2015
45
Accuracy of enzyme-linked immunospot assay for diagnosis of pleural tuberculosis: a meta-analysis. ( 26436408 )
2015
46
Interleukin-27 improves the ability of adenosine deaminase to rule out tuberculous pleural effusion regardless of pleural tuberculosis prevalence. ( 25753767 )
2015
47
Profiling the T-cell receptor repertoire of patient with pleural tuberculosis by high-throughput sequencing. ( 25173045 )
2014
48
Expression of fibroblast specific protein-1 in pleural tuberculosis and its clinical biological significance. ( 24885536 )
2014
49
Pulmonary Changes of Pleural Tuberculosis: Up-to-Date CT Imaging. ( 25086249 )
2014
50
Diagnostic utility of serum and pleural levels of adenosine deaminase 1-2, and interferon-I^ in the diagnosis of pleural tuberculosis. ( 24602306 )
2014

Variations for Pleural Tuberculosis

Expression for Pleural Tuberculosis

Search GEO for disease gene expression data for Pleural Tuberculosis.

Pathways for Pleural Tuberculosis

Pathways related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 CCL2 CXCL8 IFNG IL18 TBP TIMP1
2
Show member pathways
13.4 CCL2 CXCL8 IFNG IL18 TIMP1 TNF
3
Show member pathways
13.19 B2M CCL2 CXCL8 IFNG IL18 TIMP1
4
Show member pathways
13.17 CCL2 CXCL8 IL18 TIMP1 TNF
5
Show member pathways
12.89 CCL2 CXCL8 IFNG IL18 TNF
6
Show member pathways
12.75 B2M CXCL8 IFNG IL18 TNF
7
Show member pathways
12.65 CXCL8 IFNG IL18 TNF
8
Show member pathways
12.64 CCL2 CXCL8 IFNG IL18 TBP TNF
9 12.46 B2M CCL2 IFNG TNF
10
Show member pathways
12.44 CCL2 IFNG IL18 TIMP1 TNF
11
Show member pathways
12.21 CCL2 CXCL8 IFNG TNF
12 12.13 IFNG IL18 TNF
13
Show member pathways
12.13 CXCL8 IFNG IL18 TIMP1 TNF
14
Show member pathways
12.12 CXCL8 IL18 TNF
15
Show member pathways
12.08 CXCL8 IFNG TNF
16 11.99 CCL2 IFNG TNF
17
Show member pathways
11.96 CCL2 CXCL8 IFNG IL18 TIMP1
18
Show member pathways
11.95 IFNG IL18 TNF
19
Show member pathways
11.89 B2M IFNG IL18
20 11.87 CCL2 CXCL8 IFNG TNF
21 11.83 CCL2 CXCL8 TNF
22 11.81 CXCL8 IFNG TNF
23 11.78 CCL2 CXCL8 IL18 TIMP1 TNF
24 11.74 CXCL8 IFNG IL18
25 11.72 CXCL8 IFNG TBP
26 11.7 IFNG IL18 TNF
27
Show member pathways
11.67 CXCL8 IFNG TNF
28 11.61 CCL2 IFNG IL18 TNF
29
Show member pathways
11.58 CXCL8 IFNG TNF
30
Show member pathways
11.56 B2M IFNG TNF
31 11.53 CCL2 CXCL8 TIMP1 TNF
32 11.51 CCL2 CXCL8 IFNG IL18 TNF
33 11.5 CXCL8 IL18 TNF
34 11.35 CCL2 IFNG IL18 TNF
35 11.29 IFNG IL18 TNF
36 11.24 IFNG IL18 TNF
37 11.17 IFNG TNF
38 11.15 IFNG IL18
39 11.07 CXCL8 TNF
40 11.04 CCL2 CXCL8 IL18 TIMP1 TNF
41 11.03 IL18 TNF
42 11.03 CCL2 CXCL8 IL18 TBP TNF
43 10.98 IFNG IL18
44 10.96 CCL2 IFNG IL18 TIMP1
45 10.95 CCL2 TIMP1
46 10.95 CXCL8 TNF
47 10.89 CCL2 CXCL8 IL18 TIMP1 TNF
48 10.87 CCL2 TNF
49 10.71 CCL2 CXCL8 IFNG IL18 TNF

GO Terms for Pleural Tuberculosis

Cellular components related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 B2M CCL2 CXCL8 IFNG IL18 TIMP1
2 extracellular space GO:0005615 9.23 ADA B2M CCL2 CXCL8 IFNG IL18

Biological processes related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.84 CCL2 CXCL8 IL18 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.74 CCL2 CXCL8 TNF
3 cellular response to organic cyclic compound GO:0071407 9.65 CCL2 IL18 TNF
4 cytokine-mediated signaling pathway GO:0019221 9.65 CCL2 CXCL8 IL18 TIMP1 TNF
5 cellular response to fibroblast growth factor stimulus GO:0044344 9.61 CCL2 CXCL8
6 humoral immune response GO:0006959 9.61 CCL2 IFNG TNF
7 negative regulation of myoblast differentiation GO:0045662 9.6 IL18 TNF
8 positive regulation of protein complex assembly GO:0031334 9.59 IFNG TNF
9 positive regulation of T cell activation GO:0050870 9.58 ADA CCL2
10 protein import into nucleus, translocation GO:0000060 9.58 IFNG TNF
11 positive regulation of osteoclast differentiation GO:0045672 9.56 IFNG TNF
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.55 IFNG TNF
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 CCL2 IL18 TNF
14 PERK-mediated unfolded protein response GO:0036499 9.52 CCL2 CXCL8
15 response to molecule of bacterial origin GO:0002237 9.51 B2M CXCL8
16 neutrophil activation GO:0042119 9.49 CXCL8 IL18
17 positive regulation of neuroinflammatory response GO:0150078 9.46 IL18 TNF
18 immune response GO:0006955 9.43 B2M CCL2 CXCL8 IFNG IL18 TNF
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IFNG TNF
20 embryonic digestive tract development GO:0048566 9.33 ADA CXCL8 TNF
21 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
22 regulation of signaling receptor activity GO:0010469 9.1 CCL2 CXCL8 IFNG IL18 TIMP1 TNF

Molecular functions related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL2 CXCL8 IFNG IL18 TIMP1 TNF

Sources for Pleural Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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