MCID: PLR001
MIFTS: 49

Pleural Tuberculosis

Categories: Immune diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Pleural Tuberculosis

MalaCards integrated aliases for Pleural Tuberculosis:

Name: Pleural Tuberculosis 12 15 17 70
Tuberculous Pleurisy in Primary Progressive Tuberculosis 12
Serosal Tuberculosis of Cattle 70
Tuberculosis of Pleura 12
Tuberculous Pleuritis 12
Tuberculosis, Pleural 44
Tuberculous Pleurisy 12
Pleurisy Tuberculous 54
Pearly Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:106
ICD9CM 34 010.1 012.0
MeSH 44 D014396
NCIt 50 C26898
SNOMED-CT 67 186172004 68706009
ICD10 32 A15.6 A16.5
UMLS 70 C0041326 C0152531 C1628317

Summaries for Pleural Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in lymphocyte-predominant exudative pleural effusion, located in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

MalaCards based summary : Pleural Tuberculosis, also known as tuberculous pleurisy in primary progressive tuberculosis, is related to tuberculous peritonitis and extrapulmonary tuberculosis. An important gene associated with Pleural Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Adenosine and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include pleura, lung and skin, and related phenotypes are hematopoietic system and digestive/alimentary

Related Diseases for Pleural Tuberculosis

Diseases related to Pleural Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 553)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 31.9 TBP IFNG ADA
2 extrapulmonary tuberculosis 30.7 IFNG CCL2 ADA
3 mycobacterium tuberculosis 1 30.7 TNF IL18 IFNG CD4 CCL3 ADA
4 tuberculous empyema 30.4 TBP ADA
5 pleural disease 30.4 TNF CXCL8 CD4 ADA
6 mycoplasma pneumoniae pneumonia 30.2 TNF IL18 IFNG
7 anthracosis 30.2 TNF CXCL8 CCL2
8 intestinal tuberculosis 30.2 TNF IFNG CD4
9 pneumoconiosis 30.1 TNF CXCL8 CCL2
10 multidrug-resistant tuberculosis 30.1 TNF IFNG CD4
11 tuberculous meningitis 30.1 TNF CXCL8 CCL3 CCL2 ADA
12 enterocolitis 30.0 TNF CXCL8
13 lymph node tuberculosis 29.9 TNF IFNG CD4
14 miliary tuberculosis 29.8 TNF IFNG CD4 ADA
15 syphilis 29.7 TNF IFNG CD4 B2M
16 thyroiditis 29.7 TNF IL2 IFNG
17 pulmonary fibrosis 29.7 TIMP1 CXCL8 CCL3 CCL2
18 peritonitis 29.7 TNF IL18 CXCL8 CCL3 CCL2 B2M
19 pneumonia 29.7 TNF IFNG CXCL8 CCL3 CCL2
20 pericarditis 29.6 TNF PSG2 IFNG CXCL8 ADA
21 pleurisy 29.6 TNF IL2 IFNG CXCL8 CCL3 CCL2
22 bacterial pneumonia 29.6 TNF CXCL8 CD4 CCL3 ADA
23 respiratory failure 29.6 TNF TIMP1 CXCL8 CD4 CCL2
24 candidiasis 29.6 TNF IL2 IFNG CXCL8
25 erythema multiforme 29.6 TNF IL2 IFNG CXCL8
26 crohn's colitis 29.6 TNF IL2 IFNG CXCL8
27 toxic shock syndrome 29.6 TNF IL2 IFNG CXCL8
28 acute pancreatitis 29.5 TNF IL18 CXCL8
29 ulcerative colitis 29.5 TNF IL2 IFNG CXCL8
30 lymphopenia 29.5 IL2RA IL2 IFNG ADA
31 lung disease 29.5 TNF IL18 IFNG CXCL8 CCL3 CCL2
32 tetanus 29.5 TNF IL2RA IL2 IFNG
33 proteasome-associated autoinflammatory syndrome 1 29.5 TNF IL18 IFNG CXCL8 CCL3 CCL2
34 hairy cell leukemia 29.4 IL2RA IL2 ADA
35 lymphadenitis 29.3 TNF IL2RA IL18 IFNG CXCL8 CD4
36 t-cell lymphoblastic leukemia/lymphoma 29.3 IL2RA IL2 CD4 ADA
37 schistosomiasis 29.2 TNF IL2 IFNG CCL3 CCL2
38 viral hepatitis 29.2 TNF IL2 IFNG
39 hypereosinophilic syndrome 29.2 IL2RA IL2 IFNG CXCL8
40 pulmonary tuberculosis 29.2 TNF IL2RA IL2 IL18 IFNG CCL3
41 bacterial infectious disease 29.1 TNF IL18 IFNG CXCL8 CD4 CCL3
42 myocarditis 29.1 TNF IL2 IL18 IFNG CCL3 CCL2
43 abdominal tuberculosis 29.0 ZNF740 TNF TBP IFNG CD4 ADA
44 colitis 29.0 TNF IL2 IL18 IFNG CXCL8 CD4
45 meningitis 29.0 TNF IL2 IL18 IFNG CXCL8 CCL3
46 disease by infectious agent 28.8 TNF IL2 IL18 IFNG CD4 CCL3
47 connective tissue disease 28.7 TNF IL2 IFNG CXCL8 CD4 CCL2
48 human immunodeficiency virus type 1 28.7 TNF IL2 IFNG CD4 CCL3 CCL2
49 acquired immunodeficiency syndrome 28.5 TNF IL2RA IL2 IFNG CD4 CCL3
50 crohn's disease 28.4 TNF IL2RA IL2 IL18 IFNG CXCL8

Comorbidity relations with Pleural Tuberculosis via Phenotypic Disease Network (PDN):


Deficiency Anemia Heart Disease
Pulmonary Tuberculosis

Graphical network of the top 20 diseases related to Pleural Tuberculosis:



Diseases related to Pleural Tuberculosis

Symptoms & Phenotypes for Pleural Tuberculosis

MGI Mouse Phenotypes related to Pleural Tuberculosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 ADA B2M CD4 IFNG IL18 IL2
2 digestive/alimentary MP:0005381 9.86 ADA B2M CD4 IFNG IL18 IL2
3 immune system MP:0005387 9.73 ADA B2M CCL2 CD4 IFNG IL18
4 neoplasm MP:0002006 9.1 B2M IFNG IL2 S100A4 TIMP1 TNF

Drugs & Therapeutics for Pleural Tuberculosis

Drugs for Pleural Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational 58-61-7 60961
2
Methylprednisolone Approved, Vet_approved 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved 2921-57-5
4
Prednisolone acetate Approved, Vet_approved 52-21-1
5
Prednisolone Approved, Vet_approved 50-24-8 5755
6
Prednisolone phosphate Approved, Vet_approved 302-25-0
7
Prednisolone hemisuccinate Experimental 2920-86-7
8 Hormones
9 Methylprednisolone Acetate
10 glucocorticoids
11 Hormone Antagonists
12 Antineoplastic Agents, Hormonal
13 Anti-Inflammatory Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy Unknown status NCT01685099
2 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Among Tuberculous Pleurisy and Malignant Pleural Effusion Patients Unknown status NCT00313066
3 Diagnostic Utility of the E-Nose for Pleural TB Unknown status NCT02765087
4 Drainage of Tuberculous Pleural Effusions Completed NCT00524147
5 A Multicenter, Placebo-Controlled, Double-Blind, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Corticosteroids for Treatment of Patients With Tuberculous Pleurisy Completed NCT00338793 prednisolone
6 Evaluation of the Reproducibility of Computed Tomography for the Measurement of Tuberculosis Pleural Effusion Completed NCT01616264

Search NIH Clinical Center for Pleural Tuberculosis

Cochrane evidence based reviews: tuberculosis, pleural

Genetic Tests for Pleural Tuberculosis

Anatomical Context for Pleural Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Pleural Tuberculosis:

19
Pleura

MalaCards organs/tissues related to Pleural Tuberculosis:

40
Lung, Skin, Bone, Lymph Node, Kidney, Liver, Heart

Publications for Pleural Tuberculosis

Articles related to Pleural Tuberculosis:

(show top 50) (show all 820)
# Title Authors PMID Year
1
The diagnostic utility of adenosine deaminase isoenzymes in tuberculous pleural effusions. 54 61
19146750 2009
2
Diagnostic significance of adenosine deaminase in pleural tuberculosis. 54 61
20364749 2009
3
Evaluation of adenosine deaminase in the diagnosis of pleural tuberculosis: a Brazilian meta-analysis. 54 61
18425258 2008
4
Auxiliary tools in tuberculosis. The hemolysis in pleural fluids underestimate the values of adenosine deaminase activity determined by the method of Giusti. 61 54
18705490 2008
5
Could IFN-gamma predict the development of residual pleural thickening in tuberculous pleurisy? 61 54
18507195 2008
6
Can pleural tuberculosis be diagnosed using interferon-gamma release assays? 54 61
18708735 2008
7
Influence of storage time and temperature on pleural fluid adenosine deaminase determination. 61 54
16771922 2006
8
The clinical utility of polymerase chain reaction for the diagnosis of pleural tuberculosis. 54 61
16080088 2005
9
[Two patients with tuberculous pleurisy]. 54 61
15688842 2005
10
[A study on the Th1/Th2 cytokines in the pathogenesis of human tuberculous pleuritis]. 61 54
15196342 2004
11
Simple method for rapid diagnosis of tuberculosis pleuritis: a statistical approach. 61 54
14977737 2004
12
Diagnostic value of pleural fluid adenosine deaminase activity in tuberculous pleurisy. 54 61
14967164 2004
13
Assay of pleural fluid interleukin-6, tumour necrosis factor-alpha and interferon-gamma in the diagnosis and outcome correlation of tuberculous effusion. 54 61
14682409 2003
14
Interferon gamma levels in pleural fluid for the diagnosis of tuberculosis. 61 54
14553871 2003
15
Combined use of the polymerase chain reaction and detection of adenosine deaminase activity on pleural fluid improves the rate of diagnosis of pleural tuberculosis. 61 54
12970016 2003
16
Monocyte chemotactic protein-1 production in patients with active pulmonary tuberculosis and tuberculous pleurisy. 61 54
12861395 2003
17
Diagnostic value of adenosine deaminase in nontuberculous lymphocytic pleural effusions. 61 54
12608433 2003
18
IL-18 production in human pulmonary and pleural tuberculosis. 54 61
12472673 2002
19
HIV-1-related pleural tuberculosis: elevated production of IFN-gamma, but failure of immunity to Mycobacterium tuberculosis. 54 61
11242143 2001
20
Evaluation of polymerase chain reaction, adenosine deaminase, and interferon-gamma in pleural fluid for the differential diagnosis of pleural tuberculosis. 61 54
11083686 2000
21
Diagnosis of tuberculous pleuritis by the measurement of soluble interleukin 2 receptor in pleural fluid. 54 61
11055766 2000
22
Management of pleural effusions. 61 54
10925561 2000
23
ADA1/ADAp ratio in pleural tuberculosis: an excellent diagnostic parameter in pleural fluid. 54 61
10603631 1999
24
Evaluation of adenosine deaminase activity in the Mycobacterium tuberculosis culture supernatants. 61 54
10596453 1999
25
[Analysis of 90 cases of pleural tuberculosis in relation to adenosine deaminase levels]. 54 61
9235414 1997
26
Interferon-gamma in 388 immunocompromised and immunocompetent patients for diagnosing pleural tuberculosis. 54 61
8980981 1996
27
Combined use of pleural adenosine deaminase with lymphocyte/neutrophil ratio. Increased specificity for the diagnosis of tuberculous pleuritis. 61 54
8620715 1996
28
[Adenosine deaminase activity in the pleural effusion. A study of 64 cases]. 54 61
8149081 1994
29
Tuberculous pleural effusions: increased culture yield with bedside inoculation of pleural fluid and poor diagnostic value of adenosine deaminase. 61 54
1901672 1991
30
Elevated levels of soluble interleukin-2 receptors in tuberculous pleural effusions. 61 54
2331910 1990
31
Pleural fluid tumor necrosis factor for diagnosis of pleural tuberculosis: A systematic review and meta-analysis. 61
33609953 2021
32
Diagnostic incremental value of sputum in patients with pleural tuberculosis. 61
33295822 2021
33
[Predictive factors and biomarkers of exudative lymphocytic tuberculous pleurisy]. 61
33531187 2021
34
Risk factors associated with surgical intervention in childhood pleural tuberculosis. 61
33542398 2021
35
Use of T-SPOT.TB for the diagnosis of unconventional pleural tuberculosis is superior to ADA in high prevalence areas: a prospective analysis of 601 cases. 61
33397312 2021
36
The Utility of Pleural Fluid Lactate Dehydrogenase to Adenosine Deaminase Ratio in Pleural Tuberculosis. 61
33333531 2021
37
Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults. 61
33448348 2021
38
Phlegmonous Appearance in the Ipsilateral Paracardiac Fat without Paracardiac Lymph Node Enlargement on Chest CT Favors the Diagnosis of Pleural Tuberculosis over Malignant Pleural Effusion. 61
33287136 2020
39
Iatrogenic Bronchopleural Fistula. 61
33489597 2020
40
Performance of Xpert® MTB/RIF in diagnosing tuberculous pleuritis using thoracoscopic pleural biopsy. 61
33183269 2020
41
Xanthogranulomatous pleuritis - An unusual presentation of tuberculosis. 61
33323663 2020
42
Treatment delay in childhood pleural tuberculosis and associated factors. 61
33109109 2020
43
Pleural Tuberculosis: A Febrile Presentation Without Respiratory Symptoms. 61
33133813 2020
44
Differentiating tuberculous pleuritis from other exudative lymphocytic pleural effusions. 61
32921071 2020
45
Additive effect of dabigatran and high-dose aspirin in the development of haemorrhagic pleural effusion in a patient with tuberculous pleuritis. 61
33488990 2020
46
Mycobacterial antigens in pleural fluid mononuclear cells to diagnose pleural tuberculosis in HIV co-infected patients. 61
32611401 2020
47
Coverage of tuberculosis and diabetes mellitus screening among household contacts of tuberculosis patients: a household-based cross-sectional survey from Southern Thailand. 61
32552712 2020
48
Diagnostic value of pleural fluid T-SPOT for tuberculous pleurisy: An updated meta-analysis. 61
32501259 2020
49
PD-1-expressing MAIT cells from patients with tuberculosis exhibit elevated production of CXCL13. 61
31833092 2020
50
Accuracy of genotype MTBDRplus line probe assay in patients with tuberculous pleural effusion: comparison with clinical and culture based diagnosis. 61
31797723 2020

Variations for Pleural Tuberculosis

Expression for Pleural Tuberculosis

Search GEO for disease gene expression data for Pleural Tuberculosis.

Pathways for Pleural Tuberculosis

Pathways related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 TNF TIMP1 IL2RA IL2 IL18 IFNG
2
Show member pathways
13.82 TNF TIMP1 IL2RA IL2 IL18 CXCL8
3
Show member pathways
13.68 TNF TIMP1 TBP IL2RA IL2 IL18
4
Show member pathways
13.57 TNF TIMP1 IL2RA IL2 IL18 IFNG
5
Show member pathways
13.45 TNF TIMP1 IL2RA IL2 IL18 CXCL8
6
Show member pathways
13.33 TNF TIMP1 IL2RA IL2 IL18 CXCL8
7
Show member pathways
13.22 TNF IL2 IL18 IFNG CXCL8 CCL3
8
Show member pathways
13.17 TNF TIMP1 IL2RA IL2 IL18 IFNG
9
Show member pathways
12.96 TNF CXCL8 CD4 CCL3 CCL2 B2M
10
Show member pathways
12.91 TNF IL2RA IL2 IFNG CXCL8 CD4
11
Show member pathways
12.87 TBP CXCL8 CD4 CCL3 CCL2
12
Show member pathways
12.81 TNF IL2RA IL2 IL18 IFNG CXCL8
13
Show member pathways
12.7 TNF IL2RA IL2 IL18 IFNG CD4
14
Show member pathways
12.67 TNF IL2RA IL2 IL18 IFNG CD4
15 12.64 TNF IL2RA IL2 IFNG CCL2 B2M
16
Show member pathways
12.61 TNF TIMP1 IL2 IL18 IFNG CD4
17 12.4 TNF TBP IL2RA IL2 CD4 B2M
18
Show member pathways
12.34 TNF IL2 IFNG CCL2
19
Show member pathways
12.34 TNF IFNG CXCL8 CCL2
20
Show member pathways
12.31 TNF IL2RA IL2 IL18 CXCL8 CCL3
21
Show member pathways
12.3 TNF TIMP1 IL2RA IL2 IL18 IFNG
22 12.26 TNF IL18 CXCL8 CCL2
23 12.1 TNF IL2 IFNG CXCL8 CCL2
24 12.09 TNF IL2 IL18 CXCL8 CD4 CCL2
25 12.08 TNF IL2RA IL2 IFNG CD4
26 12.07 TNF TIMP1 IL18 CXCL8 CCL2
27 11.92 IFNG CXCL8 CCL3
28 11.9 TNF IFNG CXCL8
29 11.89 TNF CXCL8 CCL2
30 11.89 TNF IL2RA CD4
31 11.89 TBP IL2 IFNG CXCL8
32 11.86 IL2 IL18 CXCL8
33
Show member pathways
11.85 TNF IL2 IL18 IFNG CD4
34 11.84 TNF IL2 IFNG CD4
35
Show member pathways
11.84 TNF IL2RA IL2 IFNG CXCL8
36 11.81 TNF IL18 IFNG CXCL8 CCL3 CCL2
37
Show member pathways
11.76 TNF IL2 IFNG CXCL8
38 11.72 TNF TIMP1 CXCL8 CCL3 CCL2
39
Show member pathways
11.69 TNF IL2RA IL2 IFNG B2M
40 11.64 TNF IL18 CXCL8
41 11.63 TNF IL18 IFNG CCL2
42 11.6 IL2RA IL2 IFNG CD4
43 11.59 TNF IL2 IFNG
44 11.56 TNF IL2 IFNG
45 11.55 TNF IL18 IFNG CXCL8 CCL2
46
Show member pathways
11.55 IL2RA IL2 IL18 IFNG CD4 CCL3
47 11.43 TNF IL18 IFNG
48 11.38 IL2RA IL2 IFNG
49 11.36 TNF IL18 IFNG
50
Show member pathways
11.36 TNF IL2RA IL2 IFNG CCL3

GO Terms for Pleural Tuberculosis

Cellular components related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNF TIMP1 S100A4 PSG2 IL2 IL18
2 cell surface GO:0009986 9.65 TNF IL2RA CD4 B2M ADA
3 external side of plasma membrane GO:0009897 9.55 TNF IL2RA CD4 B2M ADA
4 extracellular space GO:0005615 9.36 TNF TIMP1 S100A4 IL2 IL18 IFNG

Biological processes related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.04 TNF IL18 IFNG CXCL8 CCL3
2 cell surface receptor signaling pathway GO:0007166 9.99 IL2RA IFNG CD4 CCL2
3 negative regulation of gene expression GO:0010629 9.99 TNF IFNG CXCL8 CCL3
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 TNF CD4 CCL3 CCL2
5 positive regulation of protein phosphorylation GO:0001934 9.92 TNF IL2 IFNG CD4
6 inflammatory response GO:0006954 9.85 TNF IL2RA IL18 CXCL8 CCL3 CCL2
7 cellular response to interleukin-1 GO:0071347 9.84 CXCL8 CCL3 CCL2
8 neutrophil chemotaxis GO:0030593 9.83 CXCL8 CCL3 CCL2
9 chemokine-mediated signaling pathway GO:0070098 9.83 CXCL8 CCL3 CCL2
10 positive regulation of interferon-gamma production GO:0032729 9.82 TNF IL2 IL18
11 positive regulation of T cell proliferation GO:0042102 9.8 IL2RA IL2 CD4
12 MAPK cascade GO:0000165 9.8 TNF IL2RA IL2 IL18 CCL3 CCL2
13 humoral immune response GO:0006959 9.78 TNF IFNG CCL2
14 positive regulation of interleukin-1 beta production GO:0032731 9.77 TNF IFNG CCL3
15 protein kinase B signaling GO:0043491 9.76 TNF CCL3 CCL2
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 TNF IL2 IL18 IFNG
17 positive regulation of activated T cell proliferation GO:0042104 9.71 IL2RA IL2 IL18
18 cellular response to organic cyclic compound GO:0071407 9.71 TNF IL18 CCL3 CCL2
19 positive regulation of T cell activation GO:0050870 9.7 CD4 CCL2 ADA
20 macrophage chemotaxis GO:0048246 9.69 CCL3 CCL2
21 positive regulation of T cell differentiation GO:0045582 9.69 IL2RA IL2 ADA
22 neutrophil activation GO:0042119 9.68 IL18 CXCL8
23 PERK-mediated unfolded protein response GO:0036499 9.68 CXCL8 CCL2
24 positive regulation of neuroinflammatory response GO:0150078 9.68 TNF IL18
25 cell activation GO:0001775 9.68 TIMP1 CCL3
26 negative regulation of amyloid-beta clearance GO:1900222 9.67 TNF IFNG
27 interleukin-2-mediated signaling pathway GO:0038110 9.67 IL2RA IL2
28 response to molecule of bacterial origin GO:0002237 9.67 CXCL8 B2M
29 embryonic digestive tract development GO:0048566 9.67 TNF CXCL8 ADA
30 cellular response to nicotine GO:0071316 9.65 TNF B2M
31 positive regulation of calcium-mediated signaling GO:0050850 9.65 CD4 CCL3 ADA
32 immune response GO:0006955 9.65 TNF IL2RA IL2 IL18 IFNG CXCL8
33 positive regulation of NMDA glutamate receptor activity GO:1904783 9.64 IFNG CCL2
34 regulation of regulatory T cell differentiation GO:0045589 9.63 IL2RA IL2 IFNG
35 negative regulation of lymphocyte proliferation GO:0050672 9.62 IL2RA IL2
36 positive regulation of tissue remodeling GO:0034105 9.61 IL2 IL18
37 astrocyte cell migration GO:0043615 9.59 CCL3 CCL2
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 TNF IFNG
39 regulation of T cell homeostatic proliferation GO:0046013 9.57 IL2RA IL2
40 positive regulation of vitamin D biosynthetic process GO:0060557 9.56 TNF IFNG
41 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 TNF IL18 CCL3 CCL2
42 positive regulation of nitrogen compound metabolic process GO:0051173 9.55 TNF IFNG
43 positive regulation of inflammatory response GO:0050729 9.55 TNF IL2 IL18 IFNG CCL3
44 cytokine-mediated signaling pathway GO:0019221 9.28 TNF TIMP1 IL2RA IL2 IL18 CXCL8

Molecular functions related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 TNF TIMP1 IL2 IL18 IFNG CXCL8
2 chemokine activity GO:0008009 9.13 CXCL8 CCL3 CCL2

Sources for Pleural Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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