MCID: PLR001
MIFTS: 49

Pleural Tuberculosis

Categories: Immune diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Pleural Tuberculosis

MalaCards integrated aliases for Pleural Tuberculosis:

Name: Pleural Tuberculosis 12 15 17 71
Tuberculous Pleurisy in Primary Progressive Tuberculosis 12
Serosal Tuberculosis of Cattle 71
Tuberculosis of Pleura 12
Tuberculous Pleuritis 12
Tuberculosis, Pleural 43
Tuberculous Pleurisy 12
Pleurisy Tuberculous 54
Pearly Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:106
ICD9CM 34 010.1 012.0
MeSH 43 D014396
NCIt 49 C26898
SNOMED-CT 67 186172004 186182003
ICD10 32 A15.6 A16.5
UMLS 71 C0041326 C0152531 C1628317

Summaries for Pleural Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in lymphocyte-predominant exudative pleural effusion, located in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

MalaCards based summary : Pleural Tuberculosis, also known as tuberculous pleurisy in primary progressive tuberculosis, is related to tuberculous peritonitis and tuberculous empyema. An important gene associated with Pleural Tuberculosis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tranexamic Acid and Hemostatics have been mentioned in the context of this disorder. Affiliated tissues include pleura, testes and t cells, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Pleural Tuberculosis

Diseases related to Pleural Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 473)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 33.0 TBP IFNG ADA
2 tuberculous empyema 30.6 TBP ADA
3 mycoplasma pneumoniae pneumonia 30.4 TNF IL18 IFNG
4 candidiasis 30.4 TNF IFNG CXCL8
5 crohn's colitis 30.4 TNF IFNG CXCL8
6 erythema multiforme 30.4 TNF IFNG CXCL8
7 toxic shock syndrome 30.3 TNF IFNG CXCL8
8 intestinal tuberculosis 30.3 TNF IFNG CD4
9 tularemia 30.2 TNF IL18 CD4
10 pneumoconiosis 30.2 TNF CXCL8 CCL2
11 multidrug-resistant tuberculosis 30.2 TNF IFNG CD4
12 pleurisy 30.1 TNF IFNG CXCL8 CCL3 CCL2 ADA
13 tuberculous meningitis 30.1 TNF CXCL8 CCL3 CCL2 ADA
14 colitis 30.1 TNF IL18 IFNG CXCL8
15 pleural disease 30.0 TNF IFNG CXCL8 CD4 ADA
16 schistosomiasis 30.0 TNF IFNG CCL3 CCL2
17 lymph node tuberculosis 29.9 TNF IFNG CD4
18 lymphopenia 29.8 IL2RA IL18 IFNG B2M ADA
19 mycobacterium tuberculosis 1 29.8 TNF IL18 IFNG CXCL10 CD4 CCL3
20 myocarditis 29.7 TNF IL18 IFNG CCL3 CCL2
21 miliary tuberculosis 29.7 TNF IFNG CD4 ADA
22 syphilis 29.7 TNF IFNG CD4 B2M
23 pulmonary fibrosis 29.7 TIMP1 CXCL8 CCL3 CCL2
24 peritonitis 29.7 TNF IL18 IFNG CXCL8 CCL2 B2M
25 extrapulmonary tuberculosis 29.6 TNF TBP IFNG CD4 CCL2 ADA
26 pulmonary tuberculosis 29.6 TNF IL2RA IL18 IFNG CCL3 CCL2
27 bacterial pneumonia 29.6 TNF CXCL8 CD4 CCL3 ADA
28 meningitis 29.5 TNF IL18 IFNG CXCL8 CCL3 CCL2
29 pericardial tuberculosis 29.5 TBP IFNG CD4 ADA
30 respiratory failure 29.3 TNF TIMP1 CXCL8 CXCL10 CD4
31 crohn's disease 29.3 TNF IL18 IFNG CXCL8 CD4 CCL2
32 lymphadenitis 29.2 TNF IL2RA IL18 IFNG CXCL8 CD4
33 pericarditis 29.1 TNF PSG2 IFNG CXCL8 CD4 ADA
34 acquired immunodeficiency syndrome 29.0 TNF IL2RA IFNG CD4 CCL3 B2M
35 bacterial infectious disease 28.9 TNF IL18 IFNG CXCL8 CD4 CCL3
36 proteasome-associated autoinflammatory syndrome 1 28.8 TNF IL18 IFNG CXCL8 CXCL10 CCL3
37 pneumonia 28.8 TNF IL18 IFNG CXCL8 CXCL10 CCL3
38 abdominal tuberculosis 28.6 ZNF740 TNF TBP IFNG CD4 ADA
39 lung disease 28.5 TNF IL18 IFNG CXCL8 CXCL10 CCL3
40 human immunodeficiency virus type 1 28.4 TNF IFNG CXCL10 CD4 CCL3 CCL2
41 inflammatory bowel disease 28.1 TNF TIMP1 IL2RA IL18 IFNG CXCL8
42 diabetes mellitus 28.0 TNF IL2RA IL18 IFNG CXCL8 CXCL10
43 sarcoidosis 1 28.0 TNF IL2RA IL18 IFNG CXCL10 CD4
44 immune deficiency disease 27.8 TNF IL2RA IL18 IFNG CXCL10 CD4
45 rheumatoid arthritis 27.6 TNF TIMP1 IL2RA IL18 IFNG CXCL8
46 viral infectious disease 27.4 TNF IL2RA IL18 IFNG CXCL8 CXCL10
47 secondary hemophagocytic lymphohistiocytosis 10.6 TNF ADA
48 mercury poisoning 10.5 IL18 B2M
49 autoimmune inner ear disease 10.5 TNF TIMP1
50 systemic onset juvenile idiopathic arthritis 10.5 TNF IL18

Comorbidity relations with Pleural Tuberculosis via Phenotypic Disease Network (PDN):


Deficiency Anemia Heart Disease
Pulmonary Tuberculosis

Graphical network of the top 20 diseases related to Pleural Tuberculosis:



Diseases related to Pleural Tuberculosis

Symptoms & Phenotypes for Pleural Tuberculosis

MGI Mouse Phenotypes related to Pleural Tuberculosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 ADA B2M CXCL10 IFNG IL18 IL2RA
2 hematopoietic system MP:0005397 9.9 ADA B2M CD4 CXCL10 IFNG IL18
3 digestive/alimentary MP:0005381 9.8 ADA B2M CD4 IFNG IL18 IL2RA
4 immune system MP:0005387 9.73 ADA B2M CCL2 CD4 CXCL10 IFNG
5 mortality/aging MP:0010768 9.4 ADA B2M CD4 CXCL10 IFNG IL18

Drugs & Therapeutics for Pleural Tuberculosis

Drugs for Pleural Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4 1197-18-8 5526
2 Hemostatics Phase 4
3 Antifibrinolytic Agents Phase 4
4 Coagulants Phase 4
5 Anti-Bacterial Agents Phase 3
6 Antibiotics, Antitubercular Phase 3
7
Adenosine Approved, Investigational 58-61-7 60961
8
Prednisolone phosphate Approved, Vet_approved 302-25-0
9
Methylprednisolone Approved, Vet_approved 83-43-2 6741
10
Methylprednisolone hemisuccinate Approved 2921-57-5
11 Prednisolone acetate Approved, Vet_approved 52-21-1
12
Prednisolone Approved, Vet_approved 50-24-8 5755
13
Prednisolone hemisuccinate Experimental 2920-86-7
14 Methylprednisolone Acetate
15 Hormones
16 glucocorticoids
17 Antineoplastic Agents, Hormonal
18 Hormone Antagonists
19 Anti-Inflammatory Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Tranexamic Acid Contribution in the Prevention of Perioperative Bleeding in Pulmonary Resection Surgery Completed NCT04224116 Phase 4 Tranexamic acid injection;SSI
2 A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions Completed NCT00758316 Phase 3
3 Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy Unknown status NCT01685099
4 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Among Tuberculous Pleurisy and Malignant Pleural Effusion Patients Unknown status NCT00313066
5 Development of Tuberculosis Diagnostic Kit Unknown status NCT00311207
6 Diagnostic Utility of the E-Nose for Pleural TB Unknown status NCT02765087
7 A Multicenter, Placebo-Controlled, Double-Blind, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Corticosteroids for Treatment of Patients With Tuberculous Pleurisy Completed NCT00338793 prednisolone
8 Drainage of Tuberculous Pleural Effusions Completed NCT00524147
9 Outcome of Patients Who Could Not Have Been Diagnosed by Medical Thoracoscopy Completed NCT01356979
10 Effect of Continuous Positive Airway Pressure on Fluid Absorption Among Patients With Pleural Effusion Due to Tuberculosis Completed NCT00560521
11 Evaluation of the Reproducibility of Computed Tomography for the Measurement of Tuberculosis Pleural Effusion Completed NCT01616264
12 Evaluation of Efficacy of Thrice Weekly DOTS Regimen in Tubercular Pleural Effusion at 6 Months Completed NCT01560078
13 A Study to Evaluate the Yield of Pleural Biopsy With a Flexible Cryoprobe Versus Flexible Forceps During Semirigid Thoracoscopy: a Comparative Study Completed NCT02500277
14 Assessment of the Appropriateness Admission From Emergency Departments in the Exacerbation of COPD. Validity of Explicit Criteria and Study of the Variability Between Different Centers of NHS. Multicenter Study IRYSS-Appropriateness-COPD. Completed NCT02434536

Search NIH Clinical Center for Pleural Tuberculosis

Cochrane evidence based reviews: tuberculosis, pleural

Genetic Tests for Pleural Tuberculosis

Anatomical Context for Pleural Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Pleural Tuberculosis:

19
Pleura

MalaCards organs/tissues related to Pleural Tuberculosis:

40
Testes, T Cells, Lung, Neutrophil, Myeloid, Whole Blood, Lymph Node

Publications for Pleural Tuberculosis

Articles related to Pleural Tuberculosis:

(show top 50) (show all 793)
# Title Authors PMID Year
1
The diagnostic utility of adenosine deaminase isoenzymes in tuberculous pleural effusions. 54 61
19146750 2009
2
Diagnostic significance of adenosine deaminase in pleural tuberculosis. 61 54
20364749 2009
3
Evaluation of adenosine deaminase in the diagnosis of pleural tuberculosis: a Brazilian meta-analysis. 54 61
18425258 2008
4
Auxiliary tools in tuberculosis. The hemolysis in pleural fluids underestimate the values of adenosine deaminase activity determined by the method of Giusti. 54 61
18705490 2008
5
Could IFN-gamma predict the development of residual pleural thickening in tuberculous pleurisy? 54 61
18507195 2008
6
Can pleural tuberculosis be diagnosed using interferon-gamma release assays? 61 54
18708735 2008
7
Influence of storage time and temperature on pleural fluid adenosine deaminase determination. 54 61
16771922 2006
8
The clinical utility of polymerase chain reaction for the diagnosis of pleural tuberculosis. 61 54
16080088 2005
9
[Two patients with tuberculous pleurisy]. 54 61
15688842 2005
10
[A study on the Th1/Th2 cytokines in the pathogenesis of human tuberculous pleuritis]. 54 61
15196342 2004
11
Simple method for rapid diagnosis of tuberculosis pleuritis: a statistical approach. 54 61
14977737 2004
12
Diagnostic value of pleural fluid adenosine deaminase activity in tuberculous pleurisy. 54 61
14967164 2004
13
Assay of pleural fluid interleukin-6, tumour necrosis factor-alpha and interferon-gamma in the diagnosis and outcome correlation of tuberculous effusion. 54 61
14682409 2003
14
Interferon gamma levels in pleural fluid for the diagnosis of tuberculosis. 61 54
14553871 2003
15
Combined use of the polymerase chain reaction and detection of adenosine deaminase activity on pleural fluid improves the rate of diagnosis of pleural tuberculosis. 54 61
12970016 2003
16
Monocyte chemotactic protein-1 production in patients with active pulmonary tuberculosis and tuberculous pleurisy. 61 54
12861395 2003
17
Diagnostic value of adenosine deaminase in nontuberculous lymphocytic pleural effusions. 54 61
12608433 2003
18
IL-18 production in human pulmonary and pleural tuberculosis. 61 54
12472673 2002
19
HIV-1-related pleural tuberculosis: elevated production of IFN-gamma, but failure of immunity to Mycobacterium tuberculosis. 61 54
11242143 2001
20
Evaluation of polymerase chain reaction, adenosine deaminase, and interferon-gamma in pleural fluid for the differential diagnosis of pleural tuberculosis. 61 54
11083686 2000
21
Diagnosis of tuberculous pleuritis by the measurement of soluble interleukin 2 receptor in pleural fluid. 54 61
11055766 2000
22
Management of pleural effusions. 61 54
10925561 2000
23
ADA1/ADAp ratio in pleural tuberculosis: an excellent diagnostic parameter in pleural fluid. 54 61
10603631 1999
24
Evaluation of adenosine deaminase activity in the Mycobacterium tuberculosis culture supernatants. 54 61
10596453 1999
25
[Analysis of 90 cases of pleural tuberculosis in relation to adenosine deaminase levels]. 54 61
9235414 1997
26
Interferon-gamma in 388 immunocompromised and immunocompetent patients for diagnosing pleural tuberculosis. 61 54
8980981 1996
27
Combined use of pleural adenosine deaminase with lymphocyte/neutrophil ratio. Increased specificity for the diagnosis of tuberculous pleuritis. 54 61
8620715 1996
28
[Adenosine deaminase activity in the pleural effusion. A study of 64 cases]. 54 61
8149081 1994
29
Tuberculous pleural effusions: increased culture yield with bedside inoculation of pleural fluid and poor diagnostic value of adenosine deaminase. 61 54
1901672 1991
30
Elevated levels of soluble interleukin-2 receptors in tuberculous pleural effusions. 61 54
2331910 1990
31
Coverage of tuberculosis and diabetes mellitus screening among household contacts of tuberculosis patients: a household-based cross-sectional survey from Southern Thailand. 61
32552712 2020
32
Diagnostic value of pleural fluid T-SPOT for tuberculous pleurisy: An updated meta-analysis. 61
32501259 2020
33
PD-1-expressing MAIT cells from patients with tuberculosis exhibit elevated production of CXCL13. 61
31833092 2020
34
Accuracy of genotype MTBDRplus line probe assay in patients with tuberculous pleural effusion: comparison with clinical and culture based diagnosis. 61
31797723 2020
35
Medical Thoracoscopy for Undiagnosed Exudative Pleural Effusion: Experience from Two Tertiary Care Hospitals of Nepal. 61
32347821 2020
36
Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis. 61
32224537 2020
37
Evidence that changes in antimicrobial peptides during tuberculosis are related to disease severity, clinical presentation, specific therapy and levels of immune-endocrine mediators. 61
31731048 2020
38
Characteristics of pleural effusion in IgG4-related pleuritis. 61
32071856 2020
39
Pleural tuberculosis mimicking malignant mesothelioma. 61
31768308 2020
40
Incidence and predictors of extrapulmonary tuberculosis among people living with Human Immunodeficiency Virus in Addis Ababa, Ethiopia: A retrospective cohort study. 61
32374773 2020
41
The comparison of pleural fluid TNF-α levels in tuberculous and nontuberculous pleural effusion. 61
32192626 2020
42
Predominance of Th1 Immune Response in Pleural Effusion of Patients with Tuberculosis among Other Exudative Etiologies. 61
31619524 2019
43
High expression of BTLA and B7-H4 on the surface of myeloid dendritic cells has a negative regulatory effect on their anti-tuberculosis immunity activity in pleural tuberculosis patients. 61
31677529 2019
44
Risk factors for tuberculous empyema in pleural tuberculosis patients. 61
31863026 2019
45
Diagnostic yield of sputum induction in patients with pleural tuberculosis at a tertiary care hospital in Karachi. 61
31718758 2019
46
Predictive Model for Discrimination of Tuberculous Pleural Effusion From Severe Mycoplasma pneumoniae Pneumonic Effusion in Children. 61
31626044 2019
47
Long-term efficacy of 6-month therapy with isoniazid and rifampin compared with isoniazid, rifampin, and pyrazinamide treatment for pleural tuberculosis. 61
31377953 2019
48
IgA and IgG antibody detection of mycobacterial antigens in pleural fluid and serum from pleural tuberculous patients. 61
31623558 2019
49
Pleural tuberculosis. 61
31656443 2019
50
Competence in pleural procedures. 61
30394712 2019

Variations for Pleural Tuberculosis

Expression for Pleural Tuberculosis

Search GEO for disease gene expression data for Pleural Tuberculosis.

Pathways for Pleural Tuberculosis

Pathways related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 TNF TIMP1 IL2RA IL18 IFNG CXCL8
2
Show member pathways
13.82 TNF TIMP1 IL2RA IL18 CXCL8 CXCL10
3
Show member pathways
13.62 TNF TIMP1 TBP IL2RA IL18 IFNG
4
Show member pathways
13.53 TNF TIMP1 IL2RA IL18 IFNG CXCL8
5
Show member pathways
13.41 TNF TIMP1 IL2RA IL18 CXCL8 CXCL10
6
Show member pathways
13.27 TNF TIMP1 IL2RA IL18 CXCL8 CXCL10
7
Show member pathways
13.11 TNF TIMP1 IL2RA IL18 IFNG CXCL8
8
Show member pathways
13.06 TNF IFNG CXCL8 CXCL10 CCL3 CCL2
9
Show member pathways
12.94 TNF CXCL8 CD4 CCL3 CCL2 B2M
10
Show member pathways
12.9 TBP CXCL8 CXCL10 CD4 CCL3 CCL2
11
Show member pathways
12.86 TNF IL2RA IFNG CXCL8 CD4 B2M
12
Show member pathways
12.74 TNF IL2RA IL18 IFNG CXCL8 CXCL10
13
Show member pathways
12.64 TNF IL2RA IL18 IFNG CD4
14
Show member pathways
12.61 TNF IL2RA IL18 IFNG CD4
15
Show member pathways
12.6 TNF TIMP1 IL18 IFNG CD4 CCL2
16 12.58 TNF IL2RA IFNG CXCL10 CCL2 B2M
17
Show member pathways
12.52 TNF IFNG CXCL8 CXCL10
18 12.37 TNF TBP IL2RA CD4 B2M
19
Show member pathways
12.36 TNF IFNG CXCL8 CXCL10 CCL2
20
Show member pathways
12.29 TNF TIMP1 IL2RA IL18 IFNG CXCL8
21 12.25 TNF IL18 CXCL8 CCL2
22
Show member pathways
12.2 TNF IFNG CXCL8 CXCL10
23
Show member pathways
12.2 TNF IL2RA IL18 CXCL8 CXCL10 CCL3
24 12.04 TNF IL18 CXCL8 CCL2
25 12.03 TNF IFNG CXCL8 CXCL10 CCL2
26 12.02 TNF IL2RA IFNG CD4
27 11.98 TNF TIMP1 IL18 CXCL8 CCL2
28
Show member pathways
11.97 TNF IL18 IFNG CD4
29 11.92 IFNG CXCL8 CCL3
30 11.9 TNF IFNG CXCL8
31
Show member pathways
11.9 IL2RA IL18 IFNG CD4 CCL3 B2M
32 11.89 TNF CXCL8 CCL2
33 11.88 TNF IL2RA CD4
34
Show member pathways
11.8 TNF IL2RA IFNG CXCL8
35 11.79 TBP IFNG CXCL8
36 11.75 TNF IFNG CD4
37
Show member pathways
11.7 TNF IL2RA IFNG B2M
38
Show member pathways
11.68 TNF IFNG CXCL8
39 11.65 TNF TIMP1 CXCL8 CCL3 CCL2
40 11.63 TNF IL18 CXCL8
41 11.6 TNF IL18 IFNG CXCL8 CCL3 CCL2
42 11.55 TNF IL18 IFNG CCL2
43 11.52 IL2RA IFNG CD4
44 11.5 TNF IL18 IFNG CXCL8 CCL2
45 11.42 TNF IL18 IFNG
46
Show member pathways
11.37 TNF IL2RA IFNG CCL3
47 11.35 TNF IL18 IFNG
48 11.34 TNF IL2RA IL18 IFNG CD4 CCL3
49 11.29 TNF IFNG CD4
50 11.24 IL2RA IL18 IFNG CD4

GO Terms for Pleural Tuberculosis

Cellular components related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNF TIMP1 S100A4 PSG2 IL18 IFNG
2 external side of plasma membrane GO:0009897 9.63 TNF IL2RA CXCL10 CD4 B2M ADA
3 extracellular space GO:0005615 9.36 TNF TIMP1 S100A4 IL18 IFNG CXCL8

Biological processes related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.96 IL2RA IFNG CXCL10 CD4 CCL2
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 TNF CD4 CCL3 CCL2
3 MAPK cascade GO:0000165 9.92 TNF IL2RA IL18 CCL3 CCL2
4 cellular response to lipopolysaccharide GO:0071222 9.89 TNF CXCL8 CXCL10 CCL2
5 chemotaxis GO:0006935 9.88 CXCL8 CXCL10 CCL3 CCL2
6 cellular response to interleukin-1 GO:0071347 9.82 CXCL8 CCL3 CCL2
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 TNF IL18 IFNG
8 humoral immune response GO:0006959 9.78 TNF IFNG CCL2
9 positive regulation of inflammatory response GO:0050729 9.78 TNF IL18 IFNG CCL3
10 protein kinase B signaling GO:0043491 9.75 TNF CCL3 CCL2
11 neutrophil chemotaxis GO:0030593 9.73 CXCL8 CXCL10 CCL3 CCL2
12 inflammatory response GO:0006954 9.7 TNF IL2RA IL18 CXCL8 CXCL10 CCL3
13 positive regulation of T cell activation GO:0050870 9.69 CD4 CCL2 ADA
14 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 IFNG CCL2
15 macrophage chemotaxis GO:0048246 9.67 CCL3 CCL2
16 positive regulation of chemokine biosynthetic process GO:0045080 9.67 TNF IFNG
17 cell activation GO:0001775 9.67 TIMP1 CCL3
18 negative regulation of myoblast differentiation GO:0045662 9.67 TNF IL18 CXCL10
19 chemokine-mediated signaling pathway GO:0070098 9.67 CXCL8 CXCL10 CCL3 CCL2
20 positive regulation of neuroinflammatory response GO:0150078 9.66 TNF IL18
21 neutrophil activation GO:0042119 9.66 IL18 CXCL8
22 PERK-mediated unfolded protein response GO:0036499 9.65 CXCL8 CCL2
23 T cell chemotaxis GO:0010818 9.65 CXCL10 CCL3
24 response to molecule of bacterial origin GO:0002237 9.65 CXCL8 B2M
25 immune response GO:0006955 9.65 TNF IL2RA IL18 IFNG CXCL8 CXCL10
26 negative regulation of amyloid-beta clearance GO:1900222 9.64 TNF IFNG
27 cellular response to nicotine GO:0071316 9.63 TNF B2M
28 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.63 TNF IFNG
29 embryonic digestive tract development GO:0048566 9.63 TNF CXCL8 ADA
30 cellular response to organic cyclic compound GO:0071407 9.62 TNF IL18 CCL3 CCL2
31 positive regulation of NMDA glutamate receptor activity GO:1904783 9.61 IFNG CCL2
32 astrocyte cell migration GO:0043615 9.6 CCL3 CCL2
33 positive regulation of calcium-mediated signaling GO:0050850 9.58 CD4 CCL3 ADA
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 TNF IFNG
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 TNF IL18 CCL3 CCL2
36 positive regulation of vitamin D biosynthetic process GO:0060557 9.55 TNF IFNG
37 positive regulation of nitrogen compound metabolic process GO:0051173 9.54 TNF IFNG
38 cytokine-mediated signaling pathway GO:0019221 9.28 TNF TIMP1 IL2RA IL18 CXCL8 CXCL10

Molecular functions related to Pleural Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CXCL8 CXCL10 CCL3 CCL2
2 cytokine activity GO:0005125 9.23 TNF TIMP1 IL18 IFNG CXCL8 CXCL10
3 CXCR chemokine receptor binding GO:0045236 9.16 CXCL8 CXCL10

Sources for Pleural Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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