Aliases & Classifications for Pleurisy

Summaries for Pleurisy

Disease Ontology : 12 A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs.

MalaCards based summary : Pleurisy is related to tuberculous peritonitis and pleural disease, and has symptoms including dyspnea and pleuritic pain. An important gene associated with Pleurisy is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cefazolin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, breast and t cells, and related phenotypes are cellular and cardiovascular system

Wikipedia : 73 Pleurisy, also known as pleuritis, is inflammation of the membranes that surround the lungs and line the... more...

Related Diseases for Pleurisy

Diseases related to Pleurisy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 714)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 32.0 IFNG CRP ADA
2 pleural disease 32.0 TNF CXCL8 CRP ADA
3 pleural tuberculosis 31.7 TNF IL2 IFNG CXCL8 CCL3 CCL2
4 extrapulmonary tuberculosis 31.3 TLR2 IL1RN IFNG CRP CCL2 ADA
5 pulmonary tuberculosis 30.6 TNF TLR2 IL2 IFNG CCL3 CCL2
6 constrictive pericarditis 30.5 IFNG CRP ADA
7 hypereosinophilic syndrome 30.5 MPO IL2 IFNG CXCL8 ALOX5
8 pertussis 30.4 TNF TLR4 CXCL8 CCL2
9 typhoid fever 30.2 TNF TLR4 IFNG CRP
10 spondylitis 30.2 TNF IFNG CRP
11 pulmonary fibrosis 30.2 IL1RN CXCL8 CCL3 CCL2
12 lymph node tuberculosis 30.2 TNF IFNG CRP
13 arthus reaction 30.2 TNF SELL ICAM1 ALOX5
14 pulmonary edema 30.1 TNF ICAM1 CXCL8 CRP
15 mumps 30.1 TNF IL2 IFNG CXCL8
16 allergic encephalomyelitis 30.1 CCL3 CCL2
17 mycobacterium kansasii 30.1 TLR2 CXCL8
18 abdominal tuberculosis 30.1 TNF IFNG CRP ADA
19 intestinal perforation 30.1 TNF TLR4 CRP
20 mycobacterium tuberculosis 1 30.0 TNF TLR4 TLR2 SELL IFNG CCL3
21 skeletal tuberculosis 30.0 TNF IFNG CRP
22 anthracosis 30.0 TNF CXCL8 CCL2
23 pasteurellosis 30.0 TNF MPO CXCL8
24 mycobacterium abscessus 30.0 TNF TLR2 CXCL8
25 chronic eosinophilic pneumonia 30.0 ICAM1 CCL3 CCL2
26 syphilis 29.9 TNF IFNG CRP
27 pericarditis 29.9 TNF MEFV IFNG ENO2 CXCL8 CRP
28 enthesopathy 29.9 TNF MEFV CRP
29 infective endocarditis 29.9 TNF TLR2 CRP
30 bronchiectasis 29.9 TNF TLR2 MPO CXCL8 CRP
31 cryptococcosis 29.9 TNF SELL IFNG
32 tularemia 29.9 TNF TLR4 TLR2
33 mycoplasma pneumoniae pneumonia 29.8 TNF TLR2 IFNG CRP
34 rhinitis 29.8 TNF IFNG ICAM1 CXCL8
35 amebiasis 29.8 TNF TLR2 ICAM1 CXCL8
36 systemic scleroderma 29.8 TNF IFNG CRP ADA
37 crohn's colitis 29.8 TNF IL2 IFNG CXCL8
38 acute pancreatitis 29.8 TNF TLR4 MPO CXCL8 CRP
39 herpes zoster 29.8 TNF TLR2 IL2 IFNG
40 allergic disease 29.8 TNF TLR4 TLR2 MPO IL2 IFNG
41 boutonneuse fever 29.8 TLR4 SELL IL2
42 thyroiditis 29.7 TNF IL2 IFNG CRP
43 bronchitis 29.7 TNF TLR4 TLR2 MPO CXCL8 CRP
44 bronchopneumonia 29.7 TNF TLR4 MPO CXCL8 CRP CCL3
45 interstitial lung disease 29.7 TNF IFNG ICAM1 CXCL8 CRP CCL2
46 gastric ulcer 29.7 TNF IL1RN CXCL8
47 spondyloarthropathy 1 29.7 TNF TLR4 IL1RN CRP
48 uveitis 29.7 TNF IL2 IFNG ICAM1 CXCL8 CCL2
49 peptic ulcer disease 29.7 TNF IL1RN CXCL8
50 endocarditis 29.7 TNF TLR2 IFNG CXCL8 CRP

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to Pleurisy

Symptoms & Phenotypes for Pleurisy

UMLS symptoms related to Pleurisy:


dyspnea; pleuritic pain

MGI Mouse Phenotypes related to Pleurisy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 ADA ALOX5 ENO2 EPRS1 ICAM1 IFNG
2 cardiovascular system MP:0005385 10.21 ADA ALOX5 CRP ICAM1 IFNG IL1RN
3 homeostasis/metabolism MP:0005376 10.17 ADA ALOX5 CRP EPRS1 ICAM1 IFNG
4 hematopoietic system MP:0005397 10.15 ADA ALOX5 ICAM1 IFNG IL1RN IL2
5 immune system MP:0005387 10.1 ADA ALOX5 CCL2 CRP ICAM1 IFNG
6 liver/biliary system MP:0005370 9.76 ADA IFNG IL2 MEFV SELL TLR2
7 neoplasm MP:0002006 9.5 ICAM1 IFNG IL2 SELL TLR2 TLR4
8 respiratory system MP:0005388 9.28 ADA ENO2 EPRS1 IFNG IL2 SELL

Drugs & Therapeutics for Pleurisy

Drugs for Pleurisy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefazolin Approved Phase 4 25953-19-9 33255 656510
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3 Antibiotics, Antitubercular Phase 4
4 Anti-Bacterial Agents Phase 4
5 Clindamycin palmitate Phase 4
6 Anti-Infective Agents Phase 4
7 Clindamycin phosphate Phase 4
8
Prednisolone acetate Approved, Vet_approved 52-21-1
9
Methylprednisolone Approved, Vet_approved 83-43-2 6741
10
Prednisolone Approved, Vet_approved 50-24-8 5755
11
Prednisolone phosphate Approved, Vet_approved 302-25-0
12
Methylprednisolone hemisuccinate Approved 2921-57-5
13
Prednisolone hemisuccinate Experimental 2920-86-7
14 Methylprednisolone Acetate
15 glucocorticoids
16 Hormone Antagonists
17 Hormones
18 Antineoplastic Agents, Hormonal
19 Anti-Inflammatory Agents

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of a Single Dose of an Injectable Antibiotic for the Prophylaxis of Surgical Site and Pleural Space Infection After Medical Thoracoscopy Completed NCT02446782 Phase 4 Cefazolin
2 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Among Tuberculous Pleurisy and Malignant Pleural Effusion Patients Unknown status NCT00313066
3 Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy Unknown status NCT01685099
4 A Multicenter, Placebo-Controlled, Double-Blind, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Corticosteroids for Treatment of Patients With Tuberculous Pleurisy Completed NCT00338793 prednisolone
5 A Randomized Controlled Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions Completed NCT01726556
6 Management of Parapneumonic Pleurisy Guided by an Early Pleural Ultrasound Completed NCT04348734
7 Drainage of Tuberculous Pleural Effusions Completed NCT00524147
8 Predictive Factors and Outcome in Medical Thoracoscopy Completed NCT02288065 sterile talc pleurodesis
9 A Study to Evaluate the Yield of Pleural Biopsy With a Flexible Cryoprobe Versus Flexible Forceps During Semirigid Thoracoscopy: a Comparative Study Completed NCT02500277
10 Lung Ultrasound in Pleuritic Chest Pain: a Multicenter, Prospective, Diagnostic Accuracy Study. Completed NCT02107001
11 Evaluation de la Mesure du Taux de la Procalcitonine Dans Les Liquides Pleuraux Completed NCT01011881
12 The Effect of Personalized Custom Training Videos on Patient Engagement in Hospitalized Patients Undergoing Thoracocentesis Recruiting NCT04254445

Search NIH Clinical Center for Pleurisy

Genetic Tests for Pleurisy

Anatomical Context for Pleurisy

MalaCards organs/tissues related to Pleurisy:

40
Neutrophil, Breast, T Cells, Liver, Lung, Heart, Skin

Publications for Pleurisy

Articles related to Pleurisy:

(show top 50) (show all 4189)
# Title Authors PMID Year
1
Pleural effusion adenosine deaminase (ADA) level and occult tuberculous pleurisy. 54 61
19901882 2009
2
Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. 61 54
19492852 2009
3
The diagnostic utility of adenosine deaminase isoenzymes in tuberculous pleural effusions. 54 61
19146750 2009
4
[The diagnostic value of adenosine deaminase coefficient in patients with tuberculous exudative pleurisy]. 61 54
19514456 2009
5
Pleural fluid adenosine deaminase and interferon gamma as diagnostic tools in tuberculosis pleurisy. 61 54
19218659 2008
6
[Adenosine deaminase in the blood cells and serum of patients with tuberculous pleurisy]. 61 54
18318225 2008
7
Pleural fluid neopterin levels in tuberculous pleurisy. 61 54
17531216 2007
8
[Adenosine deaminase 2 in the diagnosis of tuberculous pleuritis]. 61 54
16447785 2005
9
Diagnostic utility of serum and pleural fluid carcinoembryonic antigen, neuron-specific enolase, and cytokeratin 19 fragments in patients with effusions from primary lung cancer. 54 61
16236887 2005
10
The relation of the pleural thickening in tuberculosis pleurisy with the activity of adenosine deaminase. 54 61
16128225 2005
11
[Diagnosis and treatment of tuberculous pleurisy--with special reference to the significance of measurement of pleural fluid cytokines]. 61 54
15168435 2004
12
Diagnostic value of pleural fluid adenosine deaminase activity in tuberculous pleurisy. 61 54
14967164 2004
13
Tumour necrosis factor-alpha in comparison to adenosine deaminase in tuberculous pleuritis. 54 61
12915746 2003
14
Diagnostic significance of interferon-gamma in tuberculous pleural effusions. 61 54
12628872 2003
15
Activity of adenosine deaminase and its isoforms in pleural fluid in tuberculous pleuritis. 54 61
12388924 2002
16
Increased pleural fluid adenosine deaminase in brucellosis is difficult to differentiate from tuberculosis. 54 61
12457012 2002
17
Diagnosis of tuberculous pleuritis by the measurement of soluble interleukin 2 receptor in pleural fluid. 54 61
11055766 2000
18
A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. 61 54
10991987 2000
19
Elevated level of carcinoembryonic antigen in nonmalignant pleural effusions. 61 54
9118701 1997
20
Pleurisy in primary Sjögren's syndrome: T cell receptor beta-chain variable region gene bias and local autoantibody production in the pleural effusion. 61 54
9196874 1997
21
Combined use of pleural adenosine deaminase with lymphocyte/neutrophil ratio. Increased specificity for the diagnosis of tuberculous pleuritis. 54 61
8620715 1996
22
Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. 61 54
7700381 1995
23
Thielocin B3, a novel antiinflammatory human group II phospholipase A2 specific inhibitor from ascomycetes. 54 61
8040067 1994
24
A comparison study of IFN-gamma, ADA, and CA125 as the diagnostic parameters in tuberculous pleuritis. 54 61
8146413 1994
25
Neopterin, soluble interleukin-2 receptor and adenosine deaminase levels in pleural effusions. 61 54
8047718 1994
26
Diagnosis of tuberculosis in patients with pleural effusion in an area of HIV infection and limited diagnostic facilities. 54 61
7855915 1994
27
[Clinical significance of serum CA125 in patients with tuberculous pleurisy]. 61 54
1921093 1991
28
Adenosine deaminase in rheumatoid pleurisy. 61 54
2035103 1991
29
[The usefulness of pleural biopsy in benign or malignant pleurisy]. 54 61
2067153 1991
30
[Clinical evaluation of pleural effusion--carcinoembryonic antigen (CEA) and adenosine deaminase (ADA) activities in pleural fluids]. 61 54
2077254 1990
31
[The usefulness and limitations of adenosine deaminase in the diagnosis of tubercular pleurisy. A meta-analytical study]. 61 54
2149157 1990
32
Elevated levels of soluble interleukin-2 receptors in tuberculous pleural effusions. 54 61
2331910 1990
33
Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice. 61
32910315 2021
34
Chemical composition and anti-inflammatory activity of n-butanol extract of Piper sarmentosum Roxb. In the intestinal porcine epithelial cells (IPEC-J2). 61
33358857 2021
35
Antioxidant and anti-inflammatory action (in vivo and in vitro) from the trunk barks of Cabreúva (Myrocarpus frondosus Allemao, Fabaceae). 61
33157221 2021
36
Prevalence of mycoplasma-like lung lesions in pigs from commercial farms from Spain and Portugal. 61
33685489 2021
37
Anti-inflammatory Properties of Ethanolic Extract and 2″-O-β-D-Glucopyranosyl-vitexin Obtained from Alternanthera tenella Colla Whole Plant. 61
33646486 2021
38
Biochemical, carcass and meat quality alterations associated with different degree of lung lesions in slaughtered pigs. 61
33485247 2021
39
Pathogens associated with pleuritic pig lungs at an abattoir in Queensland Australia. 61
33751558 2021
40
IgG4-related pleural effusion with high adenosine deaminase levels: A case report and literature review. 61
33726002 2021
41
Systemic lupus erythematosus combined with primary hyperfibrinolysis and protein C and protein S deficiency: A case report. 61
33748254 2021
42
[Predictive factors and biomarkers of exudative lymphocytic tuberculous pleurisy]. 61
33531187 2021
43
Intrapleural alteplase and DNase for complex tuberculous pleurisy: a medical approach. 61
33425359 2021
44
Tuberculous Fibrosis Enhances Tumorigenic Potential via the NOX4-Autophagy Axis. 61
33567693 2021
45
Is 18F-FDG PET/CT capable of differential diagnosis from tuberculous pleurisy from malignant mesothelioma? 61
33625184 2021
46
S100A2: A potential biomarker to differentiate malignant from tuberculous pleural effusion. 61
33402562 2021
47
Latent class analysis identifies multimorbidity patterns in pigs with respiratory disease. 61
33243483 2021
48
Primary Rhabdomyosarcoma of the Pleura: A Case Report and Review of the Literature. 61
33564502 2021
49
HPLC-DAD-UV analysis, anti-inflammatory and anti-neuropathic effects of methanolic extract of Sideritis bilgeriana (lamiaceae) by NF-κB, TNF-α, IL-1β and IL-6 involvement. 61
32920137 2021
50
Managing respiratory disease in finisher pigs: Combining quantitative assessments of clinical signs and the prevalence of lung lesions at slaughter. 61
33310195 2021

Variations for Pleurisy

Expression for Pleurisy

Search GEO for disease gene expression data for Pleurisy.

Pathways for Pleurisy

Pathways related to Pleurisy according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 TNF TLR4 TLR2 SELL MPO MEFV
2
Show member pathways
13.7 TNF TLR4 IL2 IL1RN IFNG CXCL8
3
Show member pathways
13.37 TNF IL2 IL1RN IFNG ICAM1 CXCL8
4
Show member pathways
13.21 TNF TLR4 TLR2 IL2 IFNG ICAM1
5
Show member pathways
12.97 TNF TLR4 TLR2 ICAM1 CXCL8 CCL3
6
Show member pathways
12.86 TNF IL2 IFNG ICAM1 CXCL8
7
Show member pathways
12.82 TNF TLR4 TLR2 IL2 IFNG ICAM1
8
Show member pathways
12.74 TNF TLR4 TLR2 IL1RN CXCL8
9
Show member pathways
12.63 TNF TLR4 TLR2 IL2 IFNG
10
Show member pathways
12.62 TNF TLR4 TLR2 IL2 IFNG
11
Show member pathways
12.61 TNF MPO IL2 IFNG CCL2
12 12.52 TNF TLR2 MPO IL2 IL1RN IFNG
13
Show member pathways
12.39 TNF TLR2 IFNG CXCL8 CCL2
14
Show member pathways
12.39 TNF IL2 CXCL8 CCL3 CCL2
15
Show member pathways
12.31 TNF TLR4 TLR2 IFNG ALOX5
16
Show member pathways
12.28 TNF TLR4 TLR2 CXCL8
17 12.28 TNF TLR4 MEFV CXCL8 CCL2
18 12.26 TNF TLR4 TLR2 IFNG
19
Show member pathways
12.26 TNF MPO IL2 IFNG ICAM1 CRP
20 12.22 TNF TLR4 TLR2 IFNG
21
Show member pathways
12.21 TNF TLR4 TLR2 IFNG CXCL8
22 12.12 TNF IFNG ICAM1 CCL2
23 12.09 TNF TLR4 MEFV IL2 CXCL8 CCL2
24 12.05 TNF SELL MPO IL2 IFNG
25 12.03 TNF ICAM1 CXCL8 CCL2 ALOX5
26 11.99 TNF TLR4 ICAM1 CXCL8
27 11.99 TNF TLR4 IL2 IFNG ICAM1 CXCL8
28 11.97 TNF ICAM1 CXCL8 CCL2
29 11.95 TNF TLR4 TLR2 IFNG CXCL8
30 11.87 IL2 IFNG ICAM1 CXCL8
31 11.85 TNF IL2 IFNG CCL3
32
Show member pathways
11.82 TNF IL2 IFNG CXCL8
33 11.81 TNF SELL IL2 IFNG
34
Show member pathways
11.8 TNF TLR4 TLR2 IL2 IFNG
35 11.77 TNF TLR4 CXCL8
36 11.74 TNF TLR4 TLR2 ICAM1
37 11.71 TNF CXCL8 CCL3 CCL2
38
Show member pathways
11.69 TNF IL2 IFNG ICAM1 CXCL8
39
Show member pathways
11.67 TNF IL2 IFNG
40 11.65 TNF TLR4 TLR2 CXCL8
41 11.58 TNF IL2 IFNG
42 11.55 TNF IL2 IFNG
43 11.55 TNF MPO ICAM1
44 11.54 TNF TLR4 TLR2 IFNG CCL2
45 11.51 IFNG ICAM1 CXCL8
46 11.42 TNF IFNG ICAM1
47
Show member pathways
11.42 TNF IL2 IFNG CCL3
48 11.42 TNF IL1RN ICAM1 CXCL8 CCL3 CCL2
49 11.31 TNF IL2 IFNG
50 11.24 TLR2 IFNG ICAM1 CCL2

GO Terms for Pleurisy

Cellular components related to Pleurisy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF MPO LCN1 IL2 IL1RN IFNG
2 extracellular space GO:0005615 9.5 TNF MPO LCN1 IL2 IL1RN IFNG

Biological processes related to Pleurisy according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 10.1 TLR2 SELL MPO ALOX5 ADA2
2 positive regulation of gene expression GO:0010628 10.02 TNF TLR4 TLR2 IFNG CXCL8 CRP
3 response to lipopolysaccharide GO:0032496 9.97 TLR4 TLR2 MPO ICAM1
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 TNF TLR4 TLR2 ICAM1
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 TNF TLR4 ICAM1 CCL3 CCL2
6 cellular response to tumor necrosis factor GO:0071356 9.94 ICAM1 CXCL8 CCL3 CCL2
7 negative regulation of inflammatory response GO:0050728 9.93 MEFV IL2 ALOX5 ADA
8 cellular response to lipopolysaccharide GO:0071222 9.92 TNF TLR4 ICAM1 CXCL8 CCL2
9 neutrophil chemotaxis GO:0030593 9.88 CXCL8 CCL3 CCL2
10 positive regulation of interleukin-6 production GO:0032755 9.88 TNF TLR4 TLR2 IFNG
11 regulation of insulin secretion GO:0050796 9.87 TNF IFNG ALOX5
12 chemokine-mediated signaling pathway GO:0070098 9.87 CXCL8 CCL3 CCL2
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.87 TNF IL2 IFNG
14 positive regulation of tumor necrosis factor production GO:0032760 9.87 TLR4 TLR2 IFNG CCL3
15 cellular response to organic cyclic compound GO:0071407 9.86 TNF CCL3 CCL2
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR4 TLR2
17 positive regulation of interferon-gamma production GO:0032729 9.85 TNF TLR4 IL2
18 positive regulation of interleukin-8 production GO:0032757 9.85 TNF TLR4 TLR2
19 cellular response to interleukin-1 GO:0071347 9.85 ICAM1 CXCL8 CCL3 CCL2
20 cellular response to interferon-gamma GO:0071346 9.85 TLR4 TLR2 ICAM1 EPRS1 CCL3 CCL2
21 positive regulation of interleukin-12 production GO:0032735 9.83 TLR4 TLR2 IFNG
22 positive regulation of B cell proliferation GO:0030890 9.82 TLR4 IL2 ADA
23 protein kinase B signaling GO:0043491 9.82 TNF CCL3 CCL2
24 humoral immune response GO:0006959 9.81 TNF IFNG CCL2 ALOX5
25 immune response GO:0006955 9.81 TNF TLR4 TLR2 IL2 IL1RN IFNG
26 positive regulation of interleukin-1 beta production GO:0032731 9.8 TNF TLR4 IFNG CCL3
27 positive regulation of inflammatory response GO:0050729 9.8 TNF TLR4 TLR2 IL2 IFNG CCL3
28 microglial cell activation GO:0001774 9.78 TNF TLR2 IFNG
29 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 TNF TLR4 IFNG ICAM1
30 positive regulation of chemokine production GO:0032722 9.73 TNF TLR4 TLR2 IFNG
31 negative regulation of amyloid-beta clearance GO:1900222 9.71 TNF IFNG
32 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 TLR4 IFNG
33 response to molecule of bacterial origin GO:0002237 9.71 TLR2 CXCL8
34 embryonic digestive tract development GO:0048566 9.71 TNF CXCL8 ADA
35 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 TLR4 TLR2 IFNG CCL2
36 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.7 TNF TLR4
37 cellular response to lipoteichoic acid GO:0071223 9.7 TLR4 TLR2
38 negative regulation of vascular wound healing GO:0061044 9.69 TNF ALOX5
39 negative regulation of lipid storage GO:0010888 9.68 TNF CRP
40 positive regulation of NMDA glutamate receptor activity GO:1904783 9.67 IFNG CCL2
41 astrocyte cell migration GO:0043615 9.66 CCL3 CCL2
42 positive regulation of leukocyte adhesion to arterial endothelial cell GO:1904999 9.65 TNF ALOX5
43 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 TNF TLR4 TLR2 CCL3 CCL2
44 positive regulation of matrix metallopeptidase secretion GO:1904466 9.63 TLR4 TLR2
45 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 TNF IFNG
46 inosine biosynthetic process GO:0046103 9.62 ADA2 ADA
47 adenosine catabolic process GO:0006154 9.61 ADA2 ADA
48 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.6 TLR4 TLR2
49 positive regulation of vitamin D biosynthetic process GO:0060557 9.59 TNF IFNG
50 positive regulation of nitrogen compound metabolic process GO:0051173 9.58 TNF IFNG

Molecular functions related to Pleurisy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.43 CXCL8 CCL3 CCL2
2 adenosine deaminase activity GO:0004000 9.37 ADA2 ADA
3 deaminase activity GO:0019239 9.32 ADA2 ADA
4 cytokine activity GO:0005125 9.17 TNF IL2 IL1RN IFNG CXCL8 CCL3
5 glycosphingolipid binding GO:0043208 9.16 SELL IL2
6 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2

Sources for Pleurisy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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