Aliases & Classifications for Pleurisy

Summaries for Pleurisy

Disease Ontology : 12 A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs.

MalaCards based summary : Pleurisy is related to pleural tuberculosis and pleural disease, and has symptoms including dyspnea and pleuritic pain. An important gene associated with Pleurisy is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Acetylcysteine and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and neutrophil, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Pleurisy, also known as pleuritis, is inflammation of the membranes that surround the lungs and line the... more...

Related Diseases for Pleurisy

Diseases related to Pleurisy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 312)
# Related Disease Score Top Affiliating Genes
1 pleural tuberculosis 32.4 ADA CCL2 CXCL8 IFNG TNF
2 pleural disease 32.4 ADA CRP TNF
3 pleural empyema 32.0 ADA CRP
4 adult-onset still's disease 31.9 CRP MEFV TNF
5 tuberculous peritonitis 31.8 ADA CRP IFNG MUC16 TNF
6 extrapulmonary tuberculosis 31.8 ADA CCL2 IFNG
7 familial mediterranean fever 31.7 CRP MEFV TNF
8 pneumonia 30.4 CCL2 CRP CXCL8 MPO TNF
9 pulmonary tuberculosis 30.4 ADA IFNG IL2 TNF
10 arthritis 30.4 CCL2 CXCL8 IFNG TNF
11 tuberculous empyema 30.0 ADA IL2
12 pericarditis 30.0 ADA CRP IFNG MEFV TNF
13 glomerulonephritis 29.9 CCL2 ICAM1 MPO
14 rheumatoid arthritis 29.8 CCL2 CRP CXCL8 ICAM1 IFNG IL2
15 erysipelas 29.7 MEFV TNF
16 colitis 29.7 CXCL8 IFNG IL2 MPO TNF
17 interstitial lung disease 29.7 CCL2 CXCL8 IFNG TNF
18 mumps 29.7 IFNG IL2 TNF
19 lung disease 29.7 CCL2 CXCL8 MPO TNF
20 lymphadenitis 29.7 CXCL8 ICAM1 IFNG TNF
21 synovitis 29.6 CRP CXCL8 ICAM1 TNF
22 ulcerative colitis 29.5 CRP CXCL8 IFNG IL2 MPO TNF
23 pulmonary sarcoidosis 29.5 CCL2 ICAM1 IFNG IL2 TNF
24 keratoconjunctivitis 29.5 CXCL8 ICAM1 IFNG IL2 TNF
25 arthus reaction 29.5 ALOX5 ICAM1 SELL TNF
26 myocardial infarction 29.4 CCL2 CRP ICAM1 MPO SELL TNF
27 systemic lupus erythematosus 29.4 CCL2 CRP CXCL8 ICAM1 IFNG IL2
28 meningitis 29.4 ADA CCL2 CRP CXCL8 IFNG TNF
29 appendicitis 29.3 CRP CXCL8 ENO2 MPO TNF
30 tuberculous meningitis 29.1 ADA ALOX5 CCL2 CXCL8 ENO2 TNF
31 peritonitis 29.0 TNF MUC16 MPO MEFV ICAM1 CXCL8
32 asthma 28.8 ALOX5 CCL2 CXCL8 ICAM1 IFNG MPO
33 epidemic pleurodynia 11.1
34 pleuropneumonia 11.0
35 pneumothorax 10.3
36 pericardial tuberculosis 10.3 ADA IFNG
37 asymptomatic neurosyphilis 10.3 CXCL8 IFNG
38 israeli tick typhus 10.3 CCL2 CXCL8
39 cerebral aneurysms 10.3 CCL2 MPO
40 denture stomatitis 10.3 CCL2 CXCL8
41 abdominal tuberculosis 10.3 ADA CRP
42 gastrointestinal tuberculosis 10.3 ADA CRP
43 japanese spotted fever 10.3 CCL2 CRP
44 trichosporonosis 10.3 IFNG TNF
45 mononeuritis multiplex 10.3 CRP MPO
46 aortitis 10.3 CRP MPO
47 myasthenic syndrome, congenital, 1a, slow-channel 10.3 CRP CXCL8
48 mediastinitis 10.3 CRP MPO
49 anthracosis 10.3 CCL2 TNF
50 autoimmune myocarditis 10.3 IFNG TNF

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to Pleurisy

Symptoms & Phenotypes for Pleurisy

UMLS symptoms related to Pleurisy:


dyspnea, pleuritic pain

MGI Mouse Phenotypes related to Pleurisy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 ADA ALOX5 CRP ICAM1 IFNG IL2
2 cellular MP:0005384 10.02 ADA ALOX5 ENO2 ICAM1 IFNG IL2
3 hematopoietic system MP:0005397 9.97 ADA ALOX5 ICAM1 IFNG IL2 MEFV
4 homeostasis/metabolism MP:0005376 9.96 ADA ALOX5 CRP ICAM1 IFNG IL2
5 immune system MP:0005387 9.9 ADA ALOX5 CCL2 CRP ICAM1 IFNG
6 liver/biliary system MP:0005370 9.43 ADA IFNG IL2 MEFV SELL TNF
7 respiratory system MP:0005388 9.1 ADA ENO2 IFNG IL2 SELL TNF

Drugs & Therapeutics for Pleurisy

Drugs for Pleurisy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 128)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 564-25-0 54671203
3
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
4
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
5
Azithromycin Approved Phase 4,Not Applicable 83905-01-5 55185 447043
6
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
7
Cefazolin Approved Phase 4 25953-19-9 656510 33255
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 83-43-2 6741
9
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Not Applicable 302-25-0
10
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Not Applicable 2921-57-5
11
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-24-8 5755
12
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
13
Ofloxacin Approved Phase 4 82419-36-1 4583
14
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Not Applicable 2920-86-7
15 Antiviral Agents Phase 4
16 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
17 Expectorants Phase 4
18 Respiratory System Agents Phase 4
19 Antidotes Phase 4
20 Free Radical Scavengers Phase 4
21 Protective Agents Phase 4,Phase 2,Not Applicable
22 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
23 N-monoacetylcystine Phase 4
24 Antioxidants Phase 4,Phase 2
25 Antitubercular Agents Phase 4,Phase 3,Not Applicable
26 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
27 Antibiotics, Antitubercular Phase 4,Phase 3,Not Applicable
28 Antimalarials Phase 4,Phase 3,Not Applicable
29 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
30 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
31 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
32 Clindamycin palmitate Phase 4
33 Clindamycin phosphate Phase 4
34 Methylprednisolone acetate Phase 4,Phase 2,Not Applicable
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
36 Topoisomerase Inhibitors Phase 4,Not Applicable
37 Hormone Antagonists Phase 4,Phase 2,Not Applicable
38 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Not Applicable
39 Prednisolone acetate Phase 4,Phase 2,Not Applicable
40 Hormones Phase 4,Phase 2,Not Applicable
41 glucocorticoids Phase 4,Phase 2,Not Applicable
42 Gastrointestinal Agents Phase 4,Phase 2,Not Applicable
43 Anti-Infective Agents, Urinary Phase 4
44 Cytochrome P-450 Enzyme Inhibitors Phase 4
45 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
46 Neuroprotective Agents Phase 4,Phase 2,Not Applicable
47 Renal Agents Phase 4
48 Autonomic Agents Phase 4,Phase 2,Not Applicable
49 Antiemetics Phase 4,Phase 2,Not Applicable
50
Colchicine Approved Phase 3 64-86-8 6167 2833

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Effect of Long-term, High-dose N-acetylcysteine on Exacerbations of Bronchiectaisis Unknown status NCT02088216 Phase 4 N-acetylcysteine;Placebo
2 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
3 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
4 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
5 Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy Completed NCT02446782 Phase 4 Cefazolin
6 Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia Recruiting NCT02618057 Phase 4 Prednisolone;Levofloxacin
7 Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean Fever Completed NCT01705756 Phase 3 Kineret
8 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
9 Antibiotic Treatment of Gulf War Veterans' Illnesses Completed NCT00007735 Phase 3 Doxycycline (200mg/day) or Placebo
10 Abatacept in the Treatment and Prevention of Active Systemic Lupus Erythematosus (SLE) Flares in Combination With Prednisone Completed NCT00119678 Phase 2 Abatacept;Placebo;Prednisone;Abatacept
11 Effect of Green Tea on Treatment of Lupus Completed NCT02875691 Phase 2
12 Chinese Medicine on Deferring Dialysis Initiation Enrolling by invitation NCT02194946 Phase 1, Phase 2 CM therapies;CKD-related management
13 Safety and Tolerability of Rituxan With Methotrexate and Etanercept or Methotrexate and Adalimumab in Patients With Active Rheumatoid Arthritis Terminated NCT00298272 Phase 2 Placebo;Methotrexate;Etanercept;Adalimumab;Methylprednisolone
14 Intrapleural Bevacizumab After Pleural Drainage in the Context of Breast Cancer Terminated NCT02250118 Phase 1 Bevacizumab
15 Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy Unknown status NCT01685099
16 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Unknown status NCT00313066
17 Magnetic Resonance (MR) Spectroscopy In Familial Mediterranean Fever (FMF) Patients Unknown status NCT00658060
18 NSAIDs Treatment in Children With Pleuropneumonia Unknown status NCT01586299 Not Applicable Ibuprofen;Acetaminophen
19 Evaluation of a Serology Diagnostic Kit for the Detection of Genital Mycoplasma in Pregnancy Unknown status NCT01281319
20 Prevalence and Clinical Significance of Co-infection of Mycoplasma Pneumoniae in Patients With Pulmonary Tuberculosis Unknown status NCT00926601
21 Corticosteroids in the Treatment of Tuberculous Pleurisy Completed NCT00338793 Not Applicable prednisolone
22 Procalcitonin in Pleural Pleuritis Completed NCT01011881
23 Outcome of Patients Undiagnosed Under Medical Thoracoscopy Completed NCT01356979
24 Drainage of Tuberculous Pleural Effusions Completed NCT00524147 Not Applicable
25 A Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions Completed NCT01726556 Not Applicable
26 Serum Biomarkers in Diagnosis of Mesothelioma Completed NCT02029105
27 Predictive Factors and Outcome in Medical Thoracoscopy Completed NCT02288065 sterile talc pleurodesis
28 Yield of Cryoprobe vs Flexible Forceps Pleural Biopsy Completed NCT02500277 Not Applicable
29 Lung Ultrasound in Pleuritic Chest Pain Completed NCT02107001
30 Extravascular Lung Water Monitoring by Combined Ultrasound and Bioimpedance as a Guide for Treatment in Hemodialysis Patients Completed NCT01815762 Not Applicable
31 Efficiency and Safety of Pleural Biopsy Methods in the Diagnosis of Pleural Diseases Completed NCT03153501 Not Applicable
32 Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy Completed NCT00720954 Not Applicable
33 Characterize Patients With Moderately Active Rheumatoid Arthritis (RA) Completed NCT01557322 methotrexate (MTX)
34 Evaluation of Pathogenesis and Diagnosis of Mycoplasma Pneumoniae Community-acquired Pneumonia (CAP) Completed NCT03613636
35 Detection of Mycoplasma Pneumoniae Completed NCT02511262
36 The Optimization of Mycoplasm Pneumonia Antibiotic Therapy Completed NCT01259141 Not Applicable Moxifloxacin;Cephalosporins and azithromycin
37 Randomized Controlled Trial of Doxycycline to Prevent Acquisition of Mycoplasma Pneumoniae in an Outbreak Setting Completed NCT00207584 Not Applicable Doxycycline treatment
38 Chlamydia and Mycoplasma in Coronary Artery Disease Completed NCT00561028
39 Thoracic Ultrasound in the Treatment of Pleural Effusion Recruiting NCT02505763 Not Applicable
40 Pathophysiological Effects of Intrapleural Pressure Changes During Therapeutic Thoracentesis Recruiting NCT02192138 Not Applicable
41 Prediction of Relapse Risk in Stable Systemic Lupus Erythematosus Recruiting NCT02842814 Not Applicable HCQ;GC+HCQ
42 Lab to Real World Assessment of E-cigarette Abuse Liability and Appeal Recruiting NCT02520349
43 Treatment of Macrolide-resistant Mycoplasma Pneumoniae Recruiting NCT03530319 Not Applicable Doxycycline;Azithromycin
44 Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia (MCMP) Recruiting NCT02303587 Not Applicable methylprednisolone
45 Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium by Real-time Multiplex Polymerase Chain Reaction (PCR) After Pooling Pharyngeal, Anorectal and Urinary Samples, in Men Who Have Sex With Men Recruiting NCT03568695 Not Applicable
46 Automated Oxygen Administration in Patients With Hypoxemic Pneumonia and Pleuropneumonia Recruiting NCT03527992 Not Applicable
47 Exhaled Breath Condensate Assessment in Stable Non-Cystic Fibrotic Bronchiectasis Recruiting NCT03643263
48 Natural History of Nonspecific Pleuritis Diagnosed After Video-assisted-thoracoscopic-surgery Active, not recruiting NCT03270228
49 Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children Terminated NCT01217099 Not Applicable methylprednisolone;azithromycin

Search NIH Clinical Center for Pleurisy

Cochrane evidence based reviews: pleurisy

Genetic Tests for Pleurisy

Anatomical Context for Pleurisy

MalaCards organs/tissues related to Pleurisy:

41
Lung, T Cells, Neutrophil, Testes, Heart, Monocytes, Bone

Publications for Pleurisy

Articles related to Pleurisy:

(show top 50) (show all 883)
# Title Authors Year
1
Clinical Features of Nontuberculous Mycobacterial Pleurisy: A Review of 12 Cases. ( 29033435 )
2018
2
Is Xpert MTB/RIF appropriate for diagnosing tuberculous pleurisy with pleural fluid samples? A systematic review. ( 29940951 )
2018
3
Tuberculous pleurisy mimicking Mycoplasma pneumoniae infection in a previously healthy young adult: A case report. ( 29768381 )
2018
4
Bee venom stimulation into lung meridian acupoint reduces inflammation in a mouse model of carrageenan-induced pleurisy: an alternative therapeutic approach for the respiratory inflammatory disease. ( 29929357 )
2018
5
Diagnostic value of T-Spot TB combined with INF-I^ and IL-27 in tuberculous pleurisy. ( 29399137 )
2018
6
Tuberculous peritonitis and pleurisy accompanied by pulmonary cryptococcosis: A case report. ( 29756504 )
2018
7
Successful treatment of non-tuberculous mycobacterial pleurisy with acute fever by antimycobacterial therapy. ( 29437801 )
2018
8
Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and Control Inflammation in Mycobacterial-Induced Pleurisy. ( 29973541 )
2018
9
Bilateral Tuberculous Pleurisy with Subsequent Upper Lobe Predominant Pulmonary Fibrosis Mimicking Pleuroparenchymal Fibroelastosis. ( 29033441 )
2018
10
Success rate of medical thoracoscopy and talc pleurodesis in malignant pleurisy: A single-centre experience. ( 29320805 )
2018
11
Sir Winston Churchill: pneumonia, pleurisy, jaundice and atrial fibrillation at Roquebrune-Cap-Martin and Chartwell, 1958. ( 30362870 )
2018
12
Genome-wide association study of lung lesions and pleurisy in New Zealand lambs. ( 30099550 )
2018
13
The encaged lung: rapidly progressive idiopathic pleurisy. ( 30109031 )
2018
14
Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1/NRF2 pathway in rats. ( 30118661 )
2018
15
Ultrasound-Guided versus Thoracoscopic Pleural Biopsy for Diagnosing Tuberculous Pleurisy Following Inconclusive Thoracentesis: A Randomized, Controlled Trial. ( 30303950 )
2018
16
IgG4-Related Pleuritis Without Tuberculous Pleurisy. ( 30392587 )
2018
17
Long-lasting tuberculous pleurisy. ( 28546275 )
2017
18
Calea uniflora Less. attenuates the inflammatory response to carrageenan-induced pleurisy in mice. ( 27912150 )
2017
19
Long-lasting tuberculous pleurisy. ( 28546270 )
2017
20
Comparison of laboratory testing methods for the diagnosis of tuberculous pleurisy in China. ( 28674427 )
2017
21
Erratum: Evaluation of different laboratory methods for rapid diagnosis of tuberculous pleurisy. ( 28317818 )
2017
22
The roles of a ribosomal protein S19 polymer in a mouse model of carrageenan-induced acute pleurisy. ( 28190533 )
2017
23
The efficacy and safety of adjunctive corticosteroids in the treatment of tuberculous pleurisy: a systematic review and meta-analysis. ( 29137345 )
2017
24
Inhibition of inflammasome activation improves lung acute injury induced by carrageenan in a mouse model of pleurisy. ( 28461340 )
2017
25
Pirfenidone-induced Eosinophilic Pleurisy. ( 28717083 )
2017
26
Accuracy of interleukin-27 assay for the diagnosis of tuberculous pleurisy: A PRISMA-compliant meta-analysis. ( 29390341 )
2017
27
Progression of Tuberculous Pleurisy: From a Lymphocyte-Predominant Free-Flowing Effusion to a Neutrophil-Predominant Loculated Effusion. ( 28119752 )
2017
28
The Ethanolic Stem-Bark Extract of Antrocaryon micraster Inhibits Carrageenan-Induced Pleurisy and Pedal Oedema in Murine Models of Inflammation. ( 28798953 )
2017
29
Peripheral blood mononuclear cells from rat model of pleurisy: The effects of hesperidin on ectoenzymes activity, apoptosis, cell cycle and reactive oxygen species production. ( 28460230 )
2017
30
Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy. ( 28657497 )
2017
31
Antiinflammatory properties of betulinic acid and xylopic acid in the carrageenan-induced pleurisy model of lung inflammation in mice. ( 29243291 )
2017
32
Associates and predictors of pleurisy or pericarditis in SLE. ( 29118999 )
2017
33
CT findings of pulmonary tuberculosis and tuberculous pleurisy in diabetes mellitus patients. ( 28185999 )
2017
34
Mycobacterium tuberculosis Rv3615c is a highly immunodominant antigen and specifically induces potent Th1-type immune responses in tuberculosis pleurisy. ( 28588103 )
2017
35
Transmembrane Tumor Necrosis Factor Controls Myeloid-Derived Suppressor Cell Activity via TNF Receptor 2 and Protects from Excessive Inflammation during BCG-Induced Pleurisy. ( 28890718 )
2017
36
Long-term outcome of patients with nonspecific pleurisy at medical thoracoscopy. ( 28284315 )
2017
37
Diagnostic value of interferon-I^-induced protein of 10kDa for tuberculous pleurisy: A meta-analysis. ( 28577960 )
2017
38
Ulcerative colitis with acute pleurisy: A case report and review of the literature. ( 28746225 )
2017
39
Corticosteroids for tuberculous pleurisy. ( 28290161 )
2017
40
Pleurisy Caused by Mycobacterium abscessus in a Young Patient with Dermatomyositis: A Case Report and Brief Review of the Literature. ( 29269658 )
2017
41
Diagnosis of tuberculous pleurisy with combination of adenosine deaminase and interferon-γ immunospot assay in a tuberculosis-endemic population: A prospective cohort study. ( 29381918 )
2017
42
The anti-inflammatory effect of Ilex paraguariensis A. St. Hil (Mate) in a murine model of pleurisy. ( 27155392 )
2016
43
Tissue-infiltrating mucosal-associated invariant T cells play an important role against Mycobacterium tuberculosis infection in tuberculosis pleurisy. ( 27507648 )
2016
44
Role of MCP-1 in pleural effusion development in a carrageenan-induced murine model of pleurisy. ( 27878909 )
2016
45
Dynamic Analysis of Changes of Protein Levels and Selected Biochemical Indices in Rat Serum in the Course of Experimental Pleurisy. ( 27083876 )
2016
46
Evaluation of a whole-blood chemiluminescent immunoassay of IFN-I^, IP-10, and MCP-1 for diagnosis of active pulmonary tuberculosis and tuberculous pleurisy patients. ( 27523388 )
2016
47
Inhibition of the NF-I_B and p38 MAPK pathways by scopoletin reduce the inflammation caused by carrageenan in the mouse model of pleurisy. ( 27324858 )
2016
48
Analysis of Cytokine Levers in Pleural Effusions of Tuberculous Pleurisy and Tuberculous Empyema. ( 27034588 )
2016
49
Anti-inflammatory effect of volatile oil from Schizonepeta tenuifolia on carrageenin-induced pleurisy in rats and its application to study of appropriate harvesting time coupled with multi-attribute comprehensive index method. ( 27765609 )
2016
50
TB/HIV pleurisy reduces Th17 lymphocyte proportion independent of the cytokine microenvironment. ( 27450010 )
2016

Variations for Pleurisy

Expression for Pleurisy

Search GEO for disease gene expression data for Pleurisy.

Pathways for Pleurisy

Pathways related to Pleurisy according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 ALOX5 CCL2 CRP CXCL8 ICAM1 IFNG
2
Show member pathways
13.29 ALOX5 CCL2 CXCL8 ICAM1 IFNG IL2
3
Show member pathways
12.95 CCL2 CXCL8 IFNG IL2 MEFV TNF
4
Show member pathways
12.81 CXCL8 ICAM1 IFNG IL2 TNF
5
Show member pathways
12.72 CCL2 CXCL8 ICAM1 IFNG IL2 TNF
6
Show member pathways
12.53 CCL2 IFNG IL2 MPO TNF
7 12.47 ALOX5 CCL2 IFNG IL2 MPO TNF
8
Show member pathways
12.45 ICAM1 IFNG IL2 TNF
9
Show member pathways
12.29 CCL2 CXCL8 IFNG TNF
10
Show member pathways
12.2 CXCL8 IFNG IL2 TNF
11 12.05 CCL2 ICAM1 IFNG TNF
12
Show member pathways
12.03 CCL2 CXCL8 ICAM1 IFNG IL2
13
Show member pathways
11.98 IFNG IL2 TNF
14 11.9 CCL2 ICAM1 TNF
15 11.9 IFNG IL2 MPO SELL TNF
16 11.87 CCL2 CXCL8 ICAM1 TNF
17 11.86 ALOX5 CCL2 CXCL8 ICAM1 TNF
18 11.84 CXCL8 IFNG TNF
19 11.83 CXCL8 ICAM1 TNF
20 11.76 CXCL8 ICAM1 IFNG IL2
21 11.75 IFNG IL2 TNF
22
Show member pathways
11.72 CXCL8 IFNG IL2 TNF
23 11.72 CCL2 CXCL8 ICAM1 IFNG TNF
24 11.69 IFNG IL2 SELL TNF
25 11.66 CCL2 IFNG IL2 TNF
26 11.64 CCL2 CXCL8 TNF
27
Show member pathways
11.62 IFNG IL2 TNF
28
Show member pathways
11.56 ALOX5 CCL2 CRP ICAM1 IFNG IL2
29 11.54 IFNG IL2 TNF
30
Show member pathways
11.52 CXCL8 ICAM1 IFNG IL2 TNF
31 11.51 CCL2 CXCL8 ICAM1 IFNG IL2 TNF
32 11.5 ICAM1 MPO TNF
33 11.5 IFNG IL2 TNF
34 11.49 CCL2 IFNG TNF
35 11.49 CCL2 CXCL8 ICAM1 TNF
36 11.45 CXCL8 ICAM1 IFNG
37 11.33 ICAM1 IFNG TNF
38 11.24 CCL2 CXCL8 ICAM1 IFNG TNF
39 11.23 IFNG IL2 TNF
40 11.18 CCL2 CXCL8 IL2 TNF
41 11.16 CCL2 ICAM1 IFNG
42 11.02 CRP CXCL8 TNF
43 10.76 CCL2 ICAM1 MPO TNF

GO Terms for Pleurisy

Cellular components related to Pleurisy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.7 CCL2 CXCL8 ENO2 IFNG IL2 MEFV
2 extracellular region GO:0005576 9.61 ALOX5 CCL2 CRP CXCL8 IFNG IL2
3 external side of plasma membrane GO:0009897 9.56 ADA ICAM1 SELL TNF
4 extracellular space GO:0005615 9.4 ADA ALOX5 CCL2 CRP CXCL8 ENO2

Biological processes related to Pleurisy according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 CCL2 CXCL8 IFNG IL2 TNF
2 regulation of signaling receptor activity GO:0010469 9.85 CCL2 CXCL8 IFNG IL2 TNF
3 defense response GO:0006952 9.79 CXCL8 MPO TNF
4 cellular response to tumor necrosis factor GO:0071356 9.77 CCL2 CXCL8 ICAM1
5 negative regulation of inflammatory response GO:0050728 9.73 ADA IL2 MEFV
6 cellular response to lipopolysaccharide GO:0071222 9.73 CCL2 CXCL8 ICAM1 TNF
7 cell adhesion GO:0007155 9.73 ADA CCL2 ICAM1 IL2 MUC16 SELL
8 cellular response to interleukin-1 GO:0071347 9.71 CCL2 CXCL8 ICAM1
9 humoral immune response GO:0006959 9.65 CCL2 IFNG TNF
10 positive regulation of osteoclast differentiation GO:0045672 9.61 IFNG TNF
11 positive regulation of T cell differentiation GO:0045582 9.61 ADA IL2
12 leukocyte tethering or rolling GO:0050901 9.59 SELL TNF
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IFNG TNF
14 regulation of regulatory T cell differentiation GO:0045589 9.58 IFNG IL2
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 ICAM1 IFNG TNF
16 negative regulation of growth of symbiont in host GO:0044130 9.57 MPO TNF
17 PERK-mediated unfolded protein response GO:0036499 9.55 CCL2 CXCL8
18 negative regulation of lipid storage GO:0010888 9.52 CRP TNF
19 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.49 ICAM1 TNF
20 inflammatory response GO:0006954 9.43 ALOX5 CCL2 CRP CXCL8 MEFV TNF
21 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG TNF
22 embryonic digestive tract development GO:0048566 9.33 ADA CXCL8 TNF
23 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
24 cytokine-mediated signaling pathway GO:0019221 9.1 ALOX5 CCL2 CXCL8 ICAM1 IL2 TNF

Molecular functions related to Pleurisy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 ADA ALOX5 CCL2 CRP CXCL8 ENO2
2 cytokine activity GO:0005125 9.02 CCL2 CXCL8 IFNG IL2 TNF
3 glycosphingolipid binding GO:0043208 8.96 IL2 SELL

Sources for Pleurisy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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