Aliases & Classifications for Pleurisy

Summaries for Pleurisy

Disease Ontology : 12 A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs.

MalaCards based summary : Pleurisy is related to extrapulmonary tuberculosis and pleural disease, and has symptoms including dyspnea and pleuritic pain. An important gene associated with Pleurisy is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Clindamycin and Cefazolin have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and neutrophil, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 75 Pleurisy, also known as pleuritis, is inflammation of the membranes that surround the lungs and line the... more...

Related Diseases for Pleurisy

Diseases related to Pleurisy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 441)
# Related Disease Score Top Affiliating Genes
1 extrapulmonary tuberculosis 33.1 IFNG CCL2 ADA
2 pleural disease 33.0 TNF CRP ADA
3 pleural tuberculosis 33.0 TNF IFNG CXCL8 CCL2 ADA
4 pleural empyema 32.9 CRP ADA
5 adult-onset still's disease 31.9 TNF MEFV CRP
6 familial mediterranean fever 31.9 TNF MEFV CRP
7 tuberculous peritonitis 31.6 TNF MUC16 IFNG CRP ADA
8 mycobacterium tuberculosis 1 31.3 TNF IFNG ADA
9 pulmonary tuberculosis 31.0 TNF IL2 IFNG ADA
10 tuberculous empyema 30.9 IL2 ADA
11 sarcoidosis 1 30.8 TNF IL2 IFNG
12 mediastinitis 30.8 MPO CRP
13 glomerulonephritis 30.7 MPO ICAM1 CCL2
14 abdominal tuberculosis 30.7 CRP ADA
15 respiratory failure 30.5 TNF CXCL8 CRP
16 lung disease 30.5 TNF MPO CXCL8 CCL2
17 typhoid fever 30.5 TNF IFNG CRP
18 arthritis 30.4 TNF IFNG CXCL8 CCL2
19 idiopathic interstitial pneumonia 30.4 IFNG ICAM1 CXCL8 CCL2
20 variola major 30.4 IL2 IFNG
21 rheumatic disease 30.4 TNF IFNG CRP
22 aortitis 30.4 MPO CRP
23 pneumonia 30.4 TNF MPO CXCL8 CRP CCL2
24 silicosis 30.3 TNF CXCL8 CCL2
25 mumps 30.3 TNF IL2 IFNG
26 acute pancreatitis 30.3 MPO CXCL8 CRP
27 anthracosis 30.3 TNF CCL2
28 extrinsic allergic alveolitis 30.2 MPO CXCL8 CCL2
29 bacterial pneumonia 30.2 CXCL8 CRP ADA
30 acquired immunodeficiency syndrome 30.2 TNF IL2 IFNG
31 mycoplasma pneumoniae pneumonia 30.1 TNF IFNG CRP
32 pneumoconiosis 30.1 TNF CXCL8 CCL2
33 uveitis 30.1 TNF IFNG ICAM1 CCL2
34 interstitial lung disease 30.1 TNF IFNG CXCL8 CCL2
35 bronchitis 30.1 TNF MPO CXCL8 CRP
36 hematopoietic stem cell transplantation 30.0 TNF IL2 IFNG
37 pulmonary edema 30.0 TNF ICAM1 CXCL8 CRP
38 pulmonary fibrosis, idiopathic 30.0 TNF IFNG CXCL8 CCL2
39 endocarditis 30.0 TNF CXCL8 CRP
40 smallpox 30.0 TNF IL2 IFNG
41 schistosomiasis 30.0 TNF IL2 IFNG
42 kaposi sarcoma 29.9 ICAM1 CXCL8 ADA2
43 arthus reaction 29.9 TNF SELL ICAM1 ALOX5
44 pericarditis 29.9 TNF MEFV IFNG CRP ADA
45 myeloma, multiple 29.9 TNF IL2 CXCL8 CRP
46 boutonneuse fever 29.8 SELL IL2
47 temporal arteritis 29.8 TNF IFNG CRP CCL2
48 lymphadenitis 29.8 TNF IFNG ICAM1 CXCL8
49 pericardial effusion 29.8 MUC16 CRP ADA
50 chlamydia 29.7 TNF IFNG CXCL8 CRP

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to Pleurisy

Symptoms & Phenotypes for Pleurisy

UMLS symptoms related to Pleurisy:


dyspnea, pleuritic pain

MGI Mouse Phenotypes related to Pleurisy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 ADA ALOX5 CRP ICAM1 IFNG IL2
2 hematopoietic system MP:0005397 9.91 ADA ALOX5 ICAM1 IFNG IL2 MEFV
3 homeostasis/metabolism MP:0005376 9.85 ADA ALOX5 CRP ICAM1 IFNG IL2
4 immune system MP:0005387 9.7 ADA ALOX5 CCL2 CRP ICAM1 IFNG
5 liver/biliary system MP:0005370 9.1 ADA IFNG IL2 MEFV SELL TNF

Drugs & Therapeutics for Pleurisy

Drugs for Pleurisy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
2
Cefazolin Approved Phase 4 25953-19-9 656510 33255
3 Clindamycin palmitate Phase 4
4 Clindamycin phosphate Phase 4
5 Antitubercular Agents Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Anti-Infective Agents Phase 4
8 Anti-Bacterial Agents Phase 4
9
Abatacept Approved Phase 2 332348-12-6 10237
10
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
11 Hormone Antagonists Phase 2
12 Anti-Inflammatory Agents Phase 2
13 Hormones Phase 2
14 glucocorticoids Phase 2
15 Antineoplastic Agents, Hormonal Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
17 Immunologic Factors Phase 2
18 Immunosuppressive Agents Phase 2
19 Antirheumatic Agents Phase 2
20
Bevacizumab Approved, Investigational Phase 1 216974-75-3
21 Angiogenesis Inhibitors Phase 1
22 Angiogenesis Modulating Agents Phase 1
23 Antineoplastic Agents, Immunological Phase 1
24
Prednisolone phosphate Approved, Vet_approved 302-25-0
25
Methylprednisolone hemisuccinate Approved 2921-57-5
26
Methylprednisolone Approved, Vet_approved 83-43-2 6741
27
Prednisolone Approved, Vet_approved 50-24-8 5755
28
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
29
Carvedilol Approved, Investigational 72956-09-3 2585
30
Prednisolone hemisuccinate Experimental 2920-86-7
31 Methylprednisolone Acetate
32 Prednisolone acetate
33 Adjuvants, Immunologic
34 Protective Agents
35 Viscosupplements
36 Angiotensin II Type 1 Receptor Blockers
37 Angiotensin-Converting Enzyme Inhibitors
38 Dialysis Solutions
39 diuretics
40 Vasoconstrictor Agents

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of a Single Dose of an Injectable Antibiotic for the Prophylaxis of Surgical Site and Pleural Space Infection After Medical Thoracoscopy Completed NCT02446782 Phase 4 Cefazolin
2 A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions Completed NCT00758316 Phase 3
3 A Phase IIB, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Abatacept vs Placebo on a Background of Oral Glucocorticosteroids in the Treatment of Subjects With Systemic Lupus Erythematosus and the Prevention of Subsequent Lupus Flares Completed NCT00119678 Phase 2 Abatacept;Placebo;Prednisone;Abatacept
4 Phase I Study to Determine the Maximum Tolerated Dose and Evaluate the Pharmacokinetics of Intrapleural Bevacizumab After Pleural Drainage in Patients With Symptomatic Malignant Pleural Effusion in the Context of Breast Cancer Terminated NCT02250118 Phase 1 Bevacizumab
5 Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy Unknown status NCT01685099
6 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Among Tuberculous Pleurisy and Malignant Pleural Effusion Patients Unknown status NCT00313066
7 Study of Variations of Pleural and Esophageal Pressures Under Mechanical Ventilation After Lung Transplantation Unknown status NCT03179644
8 A Multicenter, Placebo-Controlled, Double-Blind, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Corticosteroids for Treatment of Patients With Tuberculous Pleurisy Completed NCT00338793 prednisolone
9 Drainage of Tuberculous Pleural Effusions Completed NCT00524147
10 Predictive Factors and Outcome in Medical Thoracoscopy Completed NCT02288065 sterile talc pleurodesis
11 A Randomized Controlled Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions Completed NCT01726556
12 Evaluation de la Mesure du Taux de la Procalcitonine Dans Les Liquides Pleuraux Completed NCT01011881
13 Lung Ultrasound in Pleuritic Chest Pain: a Multicenter, Prospective, Diagnostic Accuracy Study. Completed NCT02107001
14 PREDICTING MALIGNANT MESOTHELIOMA BY ANALYZING HYALURONAN, OSTEOPONTIN, C-ERC/MESOTHELIN, N-ERC/MESOTHELIN AND SYNDECAN-1 SERUM LEVELS Completed NCT02029105
15 Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy For Diagnosis of Patients With Pleural Effusions: A Randomized Control Trial Completed NCT00720954
16 A Study to Evaluate the Yield of Pleural Biopsy With a Flexible Cryoprobe Versus Flexible Forceps During Semirigid Thoracoscopy: a Comparative Study Completed NCT02500277
17 Extravascular Lung Water Monitoring by Combined Ultrasound and Bioimpedance as a Guide for Treatment in Hemodialysis Patients Completed NCT01815762
18 Treatment of Pleural Effusion by Routine Thoracic Ultrasound Recruiting NCT02505763
19 Lung Ultrasound Guided Fluid Management Protocol for the Critically Ill Patient: a Randomized Study Recruiting NCT03393065
20 TGF-B as a Marker of Pleurodesis in Patients With Tunneled Pleural Catheters Enrolling by invitation NCT02092155

Search NIH Clinical Center for Pleurisy

Cochrane evidence based reviews: pleurisy

Genetic Tests for Pleurisy

Anatomical Context for Pleurisy

MalaCards organs/tissues related to Pleurisy:

41
Lung, T Cells, Neutrophil, Breast, Testes, Liver, Heart

Publications for Pleurisy

Articles related to Pleurisy:

(show top 50) (show all 3922)
# Title Authors PMID Year
1
Pleural effusion adenosine deaminase (ADA) level and occult tuberculous pleurisy. 9 38
19901882 2009
2
Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. 9 38
19492852 2009
3
The diagnostic utility of adenosine deaminase isoenzymes in tuberculous pleural effusions. 9 38
19146750 2009
4
[The diagnostic value of adenosine deaminase coefficient in patients with tuberculous exudative pleurisy]. 9 38
19514456 2009
5
Pleural fluid adenosine deaminase and interferon gamma as diagnostic tools in tuberculosis pleurisy. 9 38
19218659 2008
6
[Adenosine deaminase in the blood cells and serum of patients with tuberculous pleurisy]. 9 38
18318225 2008
7
Pleural fluid neopterin levels in tuberculous pleurisy. 9 38
17531216 2007
8
[Adenosine deaminase 2 in the diagnosis of tuberculous pleuritis]. 9 38
16447785 2005
9
Diagnostic utility of serum and pleural fluid carcinoembryonic antigen, neuron-specific enolase, and cytokeratin 19 fragments in patients with effusions from primary lung cancer. 9 38
16236887 2005
10
The relation of the pleural thickening in tuberculosis pleurisy with the activity of adenosine deaminase. 9 38
16128225 2005
11
[Diagnosis and treatment of tuberculous pleurisy--with special reference to the significance of measurement of pleural fluid cytokines]. 9 38
15168435 2004
12
Diagnostic value of pleural fluid adenosine deaminase activity in tuberculous pleurisy. 9 38
14967164 2004
13
Tumour necrosis factor-alpha in comparison to adenosine deaminase in tuberculous pleuritis. 9 38
12915746 2003
14
Diagnostic significance of interferon-gamma in tuberculous pleural effusions. 9 38
12628872 2003
15
Activity of adenosine deaminase and its isoforms in pleural fluid in tuberculous pleuritis. 9 38
12388924 2002
16
Increased pleural fluid adenosine deaminase in brucellosis is difficult to differentiate from tuberculosis. 9 38
12457012 2002
17
Diagnosis of tuberculous pleuritis by the measurement of soluble interleukin 2 receptor in pleural fluid. 9 38
11055766 2000
18
A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. 9 38
10991987 2000
19
Elevated level of carcinoembryonic antigen in nonmalignant pleural effusions. 9 38
9118701 1997
20
Pleurisy in primary Sjögren's syndrome: T cell receptor beta-chain variable region gene bias and local autoantibody production in the pleural effusion. 9 38
9196874 1997
21
Combined use of pleural adenosine deaminase with lymphocyte/neutrophil ratio. Increased specificity for the diagnosis of tuberculous pleuritis. 9 38
8620715 1996
22
Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. 9 38
7700381 1995
23
Thielocin B3, a novel antiinflammatory human group II phospholipase A2 specific inhibitor from ascomycetes. 9 38
8040067 1994
24
A comparison study of IFN-gamma, ADA, and CA125 as the diagnostic parameters in tuberculous pleuritis. 9 38
8146413 1994
25
Neopterin, soluble interleukin-2 receptor and adenosine deaminase levels in pleural effusions. 9 38
8047718 1994
26
Diagnosis of tuberculosis in patients with pleural effusion in an area of HIV infection and limited diagnostic facilities. 9 38
7855915 1994
27
[Clinical significance of serum CA125 in patients with tuberculous pleurisy]. 9 38
1921093 1991
28
Adenosine deaminase in rheumatoid pleurisy. 9 38
2035103 1991
29
[The usefulness of pleural biopsy in benign or malignant pleurisy]. 9 38
2067153 1991
30
[Clinical evaluation of pleural effusion--carcinoembryonic antigen (CEA) and adenosine deaminase (ADA) activities in pleural fluids]. 9 38
2077254 1990
31
[The usefulness and limitations of adenosine deaminase in the diagnosis of tubercular pleurisy. A meta-analytical study]. 9 38
2149157 1990
32
Elevated levels of soluble interleukin-2 receptors in tuberculous pleural effusions. 9 38
2331910 1990
33
The diagnostic effect of sequential detection of ADA screening and T-SPOT assay in pleural effusion patients. 38
31379209 2019
34
Neurofibromatosis type 1-associated malignant peripheral nerve sheath tumour carcinomatous pleurisy: an autopsy case. 38
31346470 2019
35
Nivolumab alone or in combination with cisplatin plus gemcitabine in Japanese patients with unresectable or recurrent biliary tract cancer: a non-randomised, multicentre, open-label, phase 1 study. 38
31109808 2019
36
Internal Mammary Lymph Node Visualization as a Sentinel Sonographic Sign of Tuberculous Pleurisy. 38
31238381 2019
37
Antibacterial activity against porcine respiratory bacterial pathogens and in vitro biocompatibility of essential oils. 38
30955056 2019
38
[Diffuse infiltrative lung disease, pericarditis, pleural effusion and ceritinib hypersensitivity]. 38
31280988 2019
39
Diagnostic value of polymerase chain reaction/acid-fast bacilli in conjunction with computed tomography-guided pleural biopsy in tuberculous pleurisy: A diagnostic accuracy study. 38
31335667 2019
40
Bioinformatics Analysis of the Core Genes Related to Lupus Nephritis Through a Network and Pathway-Based Approach. 38
31090450 2019
41
Prospective Study of the Utility of Computed Tomography Triage of Pleural Biopsy Strategies in Patients With Pleural Diseases. 38
31211722 2019
42
Central Venous Catheter Based Closed Thoracic Drainage in the Treatment of Tuberculous Pleuritis. 38
31372136 2019
43
A 37-Year-Old Man With Pleuritic Chest Pain. 38
31279380 2019
44
Anti-hyperalgesic and anti-inflammatory effects of citral with β-cyclodextrin and hydroxypropyl-β-cyclodextrin inclusion complexes in animal models. 38
31085246 2019
45
Bilateral Pleuritis as the Initial Symptom of Systemic Lupus Erythematosus: A Case Series and Literature Review. 38
30713311 2019
46
Predictors of low disease activity and clinical remission following belimumab treatment in systemic lupus erythematosus. 38
31157891 2019
47
Anti-inflammatory Activity of Methanolic Extract and an Alkaloid from Palicourea crocea (Sw.) Roem and Schult. 38
30877508 2019
48
Sex, Symptom Severity, and Quality of Life in Rheumatology. 38
28795307 2019
49
Diagnostic role of interleukin -33 in the differentiation of pleural effusions especially tuberculous and malignant effusions. 38
31238901 2019
50
Down regulation of RANTES in pleural site is associated with inhibition of antigen specific response in tuberculosis. 38
31103419 2019

Variations for Pleurisy

Expression for Pleurisy

Search GEO for disease gene expression data for Pleurisy.

Pathways for Pleurisy

Pathways related to Pleurisy according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 TNF SELL MUC16 MPO MEFV IL2
2
Show member pathways
13.28 TNF IL2 IFNG ICAM1 CXCL8 CCL2
3
Show member pathways
13.03 TNF MEFV IL2 IFNG CXCL8 CCL2
4
Show member pathways
12.81 TNF IL2 IFNG ICAM1 CXCL8
5
Show member pathways
12.52 TNF MPO IL2 IFNG CCL2
6 12.47 TNF MPO IL2 IFNG CCL2 ALOX5
7
Show member pathways
12.45 TNF IL2 IFNG ICAM1
8
Show member pathways
12.29 TNF IFNG CXCL8 CCL2
9
Show member pathways
12.2 TNF IL2 IFNG CXCL8
10 12.04 TNF IFNG ICAM1 CCL2
11
Show member pathways
12.02 IL2 IFNG ICAM1 CXCL8 CCL2
12
Show member pathways
11.98 TNF IL2 IFNG
13 11.92 TNF SELL MPO IL2 IFNG
14 11.91 TNF ICAM1 CCL2
15 11.89 TNF ICAM1 CXCL8 CCL2 ALOX5
16 11.87 TNF ICAM1 CXCL8 CCL2
17 11.86 TNF IFNG CXCL8
18 11.86 TNF ICAM1 CXCL8
19 11.77 TNF IFNG ICAM1 CXCL8 CCL2
20 11.76 IL2 IFNG ICAM1 CXCL8
21 11.74 TNF IL2 IFNG
22
Show member pathways
11.72 TNF IL2 IFNG CXCL8
23 11.69 TNF SELL IL2 IFNG
24 11.66 TNF IL2 IFNG CCL2
25 11.64 TNF CXCL8 CCL2
26
Show member pathways
11.62 TNF IL2 IFNG
27
Show member pathways
11.56 TNF MPO IL2 IFNG ICAM1 CRP
28 11.53 TNF IL2 IFNG
29
Show member pathways
11.52 TNF IL2 IFNG ICAM1 CXCL8
30 11.51 TNF IL2 IFNG ICAM1 CXCL8 CCL2
31 11.5 TNF IFNG CCL2
32 11.49 TNF IL2 IFNG
33 11.49 TNF MPO ICAM1
34 11.49 TNF ICAM1 CXCL8 CCL2
35 11.44 IFNG ICAM1 CXCL8
36 11.35 TNF IFNG ICAM1
37 11.24 TNF IFNG ICAM1 CXCL8 CCL2
38 11.22 TNF IL2 IFNG
39 11.18 TNF IL2 CXCL8 CCL2
40 11.15 IFNG ICAM1 CCL2
41 11.01 TNF CXCL8 CRP
42 10.76 TNF MPO ICAM1 CCL2

GO Terms for Pleurisy

Cellular components related to Pleurisy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TNF MUC16 MPO IL2 IFNG CXCL8
2 external side of plasma membrane GO:0009897 9.46 TNF SELL ICAM1 ADA
3 extracellular space GO:0005615 9.4 TNF MUC16 MPO IL2 IFNG ICAM1

Biological processes related to Pleurisy according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 TNF IL2 IFNG CXCL8 CCL2
2 defense response GO:0006952 9.8 TNF MPO CXCL8
3 cellular response to tumor necrosis factor GO:0071356 9.78 ICAM1 CXCL8 CCL2
4 cellular response to lipopolysaccharide GO:0071222 9.78 TNF ICAM1 CXCL8 CCL2
5 negative regulation of inflammatory response GO:0050728 9.74 MEFV IL2 ADA
6 cell adhesion GO:0007155 9.73 SELL MUC16 IL2 ICAM1 CCL2 ADA
7 cellular response to interleukin-1 GO:0071347 9.72 ICAM1 CXCL8 CCL2
8 humoral immune response GO:0006959 9.67 TNF IFNG CCL2
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 TNF IFNG ICAM1
10 positive regulation of osteoclast differentiation GO:0045672 9.62 TNF IFNG
11 positive regulation of T cell differentiation GO:0045582 9.61 IL2 ADA
12 leukocyte tethering or rolling GO:0050901 9.6 TNF SELL
13 regulation of regulatory T cell differentiation GO:0045589 9.59 IL2 IFNG
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 TNF IFNG
15 negative regulation of growth of symbiont in host GO:0044130 9.58 TNF MPO
16 PERK-mediated unfolded protein response GO:0036499 9.56 CXCL8 CCL2
17 negative regulation of lipid storage GO:0010888 9.54 TNF CRP
18 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.51 TNF ICAM1
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IFNG
20 inflammatory response GO:0006954 9.43 TNF MEFV CXCL8 CRP CCL2 ALOX5
21 inosine biosynthetic process GO:0046103 9.4 ADA2 ADA
22 adenosine catabolic process GO:0006154 9.37 ADA2 ADA
23 embryonic digestive tract development GO:0048566 9.33 TNF CXCL8 ADA
24 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 TNF IFNG
25 cytokine-mediated signaling pathway GO:0019221 9.1 TNF IL2 ICAM1 CXCL8 CCL2 ALOX5

Molecular functions related to Pleurisy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenosine deaminase activity GO:0004000 9.26 ADA2 ADA
2 deaminase activity GO:0019239 9.16 ADA2 ADA
3 cytokine activity GO:0005125 9.02 TNF IL2 IFNG CXCL8 CCL2
4 glycosphingolipid binding GO:0043208 8.96 SELL IL2

Sources for Pleurisy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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