Aliases & Classifications for Pleurisy

Summaries for Pleurisy

Disease Ontology : 12 A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs.

MalaCards based summary : Pleurisy is related to tuberculous peritonitis and pleural tuberculosis, and has symptoms including dyspnea and pleuritic pain. An important gene associated with Pleurisy is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cefazolin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and t cells, and related phenotypes are cellular and cardiovascular system

Wikipedia : 74 Pleurisy, also known as pleuritis, is inflammation of the membranes that surround the lungs and line the... more...

Related Diseases for Pleurisy

Diseases related to Pleurisy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 658)
# Related Disease Score Top Affiliating Genes
1 tuberculous peritonitis 33.1 IFNG CRP ADA
2 pleural tuberculosis 32.9 TNF IL2 IFNG CXCL8 CCL3 CCL2
3 pleural disease 32.8 TNF IFNG CXCL8 CRP ADA
4 extrapulmonary tuberculosis 32.0 TNF TLR2 IL1RN IFNG CRP CCL2
5 adult-onset still's disease 31.6 TNF MEFV IL1RN CXCL8 CRP
6 familial mediterranean fever 31.3 TNF TLR4 TLR2 MEFV IL1RN CRP
7 pulmonary fibrosis 30.7 MPO CXCL8 CCL3 CCL2
8 idiopathic interstitial pneumonia 30.7 IFNG ICAM1 CXCL8 CCL2
9 pertussis 30.6 TNF TLR4 CXCL8 CCL2
10 constrictive pericarditis 30.6 IL1RN CRP ADA
11 hypereosinophilic syndrome 30.6 MPO IL2 IFNG CXCL8 ALOX5
12 typhoid fever 30.4 TNF TLR4 IFNG CRP
13 allergic encephalomyelitis 30.4 CCL3 CCL2
14 abdominal tuberculosis 30.4 TNF IFNG CRP ADA
15 pulmonary edema 30.4 TNF ICAM1 CXCL8 CRP
16 mycobacterium kansasii 30.4 TLR2 CXCL8
17 mumps 30.4 TNF IL2 IFNG CXCL8
18 arthus reaction 30.3 TNF SELL ICAM1 ALOX5
19 glomerulonephritis 30.3 MPO ICAM1 CCL2 ALOX5
20 mycobacterium abscessus 30.3 TNF TLR2 CXCL8
21 chronic eosinophilic pneumonia 30.3 ICAM1 CCL3 CCL2
22 skeletal tuberculosis 30.3 IFNG CRP
23 bronchopneumonia 30.2 TNF TLR4 MPO CXCL8 CRP
24 pulmonary tuberculosis 30.1 TNF TLR4 TLR2 IL2 IFNG CRP
25 tularemia 30.1 TNF TLR4 TLR2
26 spondylitis 30.1 TNF IL1RN IFNG CRP
27 mycobacterium tuberculosis 1 30.1 TNF TLR4 TLR2 SELL IFNG CRP
28 cryptococcosis 30.1 TNF SELL IFNG
29 rhinitis 30.1 TNF IFNG ICAM1 CXCL8
30 mycoplasma pneumoniae pneumonia 30.1 TNF TLR2 IFNG CRP
31 retinal detachment 30.1 TNF IFNG CXCL8 CCL2
32 bronchiectasis 30.1 TNF TLR2 MPO CXCL8 CRP
33 neuroretinitis 30.1 IFNG CRP
34 crohn's colitis 30.0 TNF IL2 IFNG CXCL8
35 enthesopathy 30.0 TNF MEFV CRP
36 boutonneuse fever 30.0 TLR4 SELL IL2
37 acute pancreatitis 30.0 TNF TLR4 MPO CXCL8 CRP
38 spondyloarthropathy 1 30.0 TNF TLR4 IL1RN CRP
39 aortitis 29.9 TNF MPO IL1RN CRP
40 interstitial lung disease 29.9 TNF IFNG ICAM1 CXCL8 CRP CCL2
41 bronchitis 29.9 TNF TLR4 TLR2 MPO CXCL8 CRP
42 pneumoconiosis 29.9 TNF IL1RN CXCL8 CCL2
43 peptic ulcer disease 29.9 TNF IL1RN CXCL8
44 mastitis 29.9 TLR2 IL1RN ICAM1 CXCL8
45 endocarditis 29.9 TNF TLR2 IFNG CXCL8 CRP
46 chickenpox 29.9 TNF IL2 IFNG CRP ADA
47 uveitis 29.9 TNF IL2 IFNG ICAM1 CXCL8 CCL2
48 silicosis 29.8 TNF TLR4 IL1RN CXCL8 CCL2
49 colitis 29.8 TNF TLR4 TLR2 MPO IL2 IFNG
50 pulmonary sarcoidosis 29.8 TNF IL2 IFNG ICAM1 CCL3 CCL2

Graphical network of the top 20 diseases related to Pleurisy:



Diseases related to Pleurisy

Symptoms & Phenotypes for Pleurisy

UMLS symptoms related to Pleurisy:


dyspnea, pleuritic pain

MGI Mouse Phenotypes related to Pleurisy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.27 ADA ALOX5 ENO2 EPRS1 ICAM1 IFNG
2 cardiovascular system MP:0005385 10.26 ADA ALOX5 CRP ICAM1 IFNG IL1RN
3 growth/size/body region MP:0005378 10.21 ADA ENO2 EPRS1 ICAM1 IFNG IL1RN
4 homeostasis/metabolism MP:0005376 10.21 ADA ALOX5 CRP EPRS1 ICAM1 IFNG
5 hematopoietic system MP:0005397 10.18 ADA ALOX5 ICAM1 IFNG IL1RN IL2
6 immune system MP:0005387 10.17 ADA ALOX5 CCL2 CRP ICAM1 IFNG
7 integument MP:0010771 9.91 EPRS1 ICAM1 IFNG IL1RN MEFV SELL
8 liver/biliary system MP:0005370 9.76 ADA IFNG IL2 MEFV SELL TLR2
9 neoplasm MP:0002006 9.5 ICAM1 IFNG IL2 SELL TLR2 TLR4
10 respiratory system MP:0005388 9.28 ADA ENO2 EPRS1 IFNG IL2 SELL

Drugs & Therapeutics for Pleurisy

Drugs for Pleurisy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefazolin Approved Phase 4 25953-19-9 656510 33255
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3 Antitubercular Agents Phase 4
4 Anti-Bacterial Agents Phase 4
5 Antibiotics, Antitubercular Phase 4
6 Clindamycin phosphate Phase 4
7 Clindamycin palmitate Phase 4
8 Anti-Infective Agents Phase 4
9
Abatacept Approved Phase 2 332348-12-6 10237
10
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
11 Hormone Antagonists Phase 2
12 Anti-Inflammatory Agents Phase 2
13 glucocorticoids Phase 2
14 Antineoplastic Agents, Hormonal Phase 2
15 Hormones Phase 2
16 Immunosuppressive Agents Phase 2
17 Immunologic Factors Phase 2
18 Antirheumatic Agents Phase 2
19
Bevacizumab Approved, Investigational Phase 1 216974-75-3
20 Antineoplastic Agents, Immunological Phase 1
21 Angiogenesis Inhibitors Phase 1
22
Methylprednisolone Approved, Vet_approved 83-43-2 6741
23
Prednisolone Approved, Vet_approved 50-24-8 5755
24
Methylprednisolone hemisuccinate Approved 2921-57-5
25 Prednisolone acetate Approved, Vet_approved 52-21-1
26
Prednisolone phosphate Approved, Vet_approved 302-25-0
27
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
28
Carvedilol Approved, Investigational 72956-09-3 2585
29
Prednisolone hemisuccinate Experimental 2920-86-7
30 Methylprednisolone Acetate
31 Adjuvants, Immunologic
32 Protective Agents
33 Viscosupplements
34 Angiotensin II Type 1 Receptor Blockers
35 Angiotensin-Converting Enzyme Inhibitors
36 Dialysis Solutions
37 Vasoconstrictor Agents
38 diuretics

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Efficacy and Safety of a Single Dose of an Injectable Antibiotic for the Prophylaxis of Surgical Site and Pleural Space Infection After Medical Thoracoscopy Completed NCT02446782 Phase 4 Cefazolin
2 A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions Completed NCT00758316 Phase 3
3 A Phase IIB, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Abatacept vs Placebo on a Background of Oral Glucocorticosteroids in the Treatment of Subjects With Systemic Lupus Erythematosus and the Prevention of Subsequent Lupus Flares Completed NCT00119678 Phase 2 Abatacept;Placebo;Prednisone;Abatacept
4 Phase I Study to Determine the Maximum Tolerated Dose and Evaluate the Pharmacokinetics of Intrapleural Bevacizumab After Pleural Drainage in Patients With Symptomatic Malignant Pleural Effusion in the Context of Breast Cancer Terminated NCT02250118 Phase 1 Bevacizumab
5 Evaluating the Diagnostic Validity of Inflammation-associated Markers for Tuberculous Pleurisy Unknown status NCT01685099
6 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Among Tuberculous Pleurisy and Malignant Pleural Effusion Patients Unknown status NCT00313066
7 Study of Variations of Pleural and Esophageal Pressures Under Mechanical Ventilation After Lung Transplantation Unknown status NCT03179644
8 A Multicenter, Placebo-Controlled, Double-Blind, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Corticosteroids for Treatment of Patients With Tuberculous Pleurisy Completed NCT00338793 prednisolone
9 Drainage of Tuberculous Pleural Effusions Completed NCT00524147
10 Predictive Factors and Outcome in Medical Thoracoscopy Completed NCT02288065 sterile talc pleurodesis
11 A Randomized Controlled Trial of Rigid Versus Semirigid Thoracoscopy in the Evaluation of Exudative Pleural Effusions Completed NCT01726556
12 Evaluation de la Mesure du Taux de la Procalcitonine Dans Les Liquides Pleuraux Completed NCT01011881
13 PREDICTING MALIGNANT MESOTHELIOMA BY ANALYZING HYALURONAN, OSTEOPONTIN, C-ERC/MESOTHELIN, N-ERC/MESOTHELIN AND SYNDECAN-1 SERUM LEVELS Completed NCT02029105
14 Lung Ultrasound in Pleuritic Chest Pain: a Multicenter, Prospective, Diagnostic Accuracy Study. Completed NCT02107001
15 A Study to Evaluate the Yield of Pleural Biopsy With a Flexible Cryoprobe Versus Flexible Forceps During Semirigid Thoracoscopy: a Comparative Study Completed NCT02500277
16 Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy For Diagnosis of Patients With Pleural Effusions: A Randomized Control Trial Completed NCT00720954
17 Extravascular Lung Water Monitoring by Combined Ultrasound and Bioimpedance as a Guide for Treatment in Hemodialysis Patients Completed NCT01815762
18 Treatment of Pleural Effusion by Routine Thoracic Ultrasound Recruiting NCT02505763
19 Lung Ultrasound Guided Fluid Management Protocol for the Critically Ill Patient: a Randomized Study Recruiting NCT03393065
20 TGF-B as a Marker of Pleurodesis in Patients With Tunneled Pleural Catheters Enrolling by invitation NCT02092155
21 Comparison of the Efficacy of Comprehensive Respiratory Physiotherapy in Children With Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis Not yet recruiting NCT04170114

Search NIH Clinical Center for Pleurisy

Cochrane evidence based reviews: pleurisy

Genetic Tests for Pleurisy

Anatomical Context for Pleurisy

MalaCards organs/tissues related to Pleurisy:

40
Lung, Neutrophil, T Cells, Liver, Breast, Testes, Heart

Publications for Pleurisy

Articles related to Pleurisy:

(show top 50) (show all 3960)
# Title Authors PMID Year
1
Pleural effusion adenosine deaminase (ADA) level and occult tuberculous pleurisy. 54 61
19901882 2009
2
Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. 54 61
19492852 2009
3
The diagnostic utility of adenosine deaminase isoenzymes in tuberculous pleural effusions. 54 61
19146750 2009
4
[The diagnostic value of adenosine deaminase coefficient in patients with tuberculous exudative pleurisy]. 54 61
19514456 2009
5
Pleural fluid adenosine deaminase and interferon gamma as diagnostic tools in tuberculosis pleurisy. 54 61
19218659 2008
6
[Adenosine deaminase in the blood cells and serum of patients with tuberculous pleurisy]. 54 61
18318225 2008
7
Pleural fluid neopterin levels in tuberculous pleurisy. 54 61
17531216 2007
8
[Adenosine deaminase 2 in the diagnosis of tuberculous pleuritis]. 54 61
16447785 2005
9
Diagnostic utility of serum and pleural fluid carcinoembryonic antigen, neuron-specific enolase, and cytokeratin 19 fragments in patients with effusions from primary lung cancer. 54 61
16236887 2005
10
The relation of the pleural thickening in tuberculosis pleurisy with the activity of adenosine deaminase. 54 61
16128225 2005
11
[Diagnosis and treatment of tuberculous pleurisy--with special reference to the significance of measurement of pleural fluid cytokines]. 54 61
15168435 2004
12
Diagnostic value of pleural fluid adenosine deaminase activity in tuberculous pleurisy. 54 61
14967164 2004
13
Tumour necrosis factor-alpha in comparison to adenosine deaminase in tuberculous pleuritis. 54 61
12915746 2003
14
Diagnostic significance of interferon-gamma in tuberculous pleural effusions. 54 61
12628872 2003
15
Activity of adenosine deaminase and its isoforms in pleural fluid in tuberculous pleuritis. 54 61
12388924 2002
16
Increased pleural fluid adenosine deaminase in brucellosis is difficult to differentiate from tuberculosis. 54 61
12457012 2002
17
Diagnosis of tuberculous pleuritis by the measurement of soluble interleukin 2 receptor in pleural fluid. 54 61
11055766 2000
18
A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. 54 61
10991987 2000
19
Pleurisy in primary Sjögren's syndrome: T cell receptor beta-chain variable region gene bias and local autoantibody production in the pleural effusion. 54 61
9196874 1997
20
Elevated level of carcinoembryonic antigen in nonmalignant pleural effusions. 54 61
9118701 1997
21
Combined use of pleural adenosine deaminase with lymphocyte/neutrophil ratio. Increased specificity for the diagnosis of tuberculous pleuritis. 54 61
8620715 1996
22
Anti-inflammatory properties of a platelet-activating factor acetylhydrolase. 54 61
7700381 1995
23
Thielocin B3, a novel antiinflammatory human group II phospholipase A2 specific inhibitor from ascomycetes. 54 61
8040067 1994
24
A comparison study of IFN-gamma, ADA, and CA125 as the diagnostic parameters in tuberculous pleuritis. 54 61
8146413 1994
25
Neopterin, soluble interleukin-2 receptor and adenosine deaminase levels in pleural effusions. 54 61
8047718 1994
26
Diagnosis of tuberculosis in patients with pleural effusion in an area of HIV infection and limited diagnostic facilities. 54 61
7855915 1994
27
[Clinical significance of serum CA125 in patients with tuberculous pleurisy]. 54 61
1921093 1991
28
Adenosine deaminase in rheumatoid pleurisy. 54 61
2035103 1991
29
[The usefulness of pleural biopsy in benign or malignant pleurisy]. 54 61
2067153 1991
30
[Clinical evaluation of pleural effusion--carcinoembryonic antigen (CEA) and adenosine deaminase (ADA) activities in pleural fluids]. 54 61
2077254 1990
31
[The usefulness and limitations of adenosine deaminase in the diagnosis of tubercular pleurisy. A meta-analytical study]. 54 61
2149157 1990
32
Elevated levels of soluble interleukin-2 receptors in tuberculous pleural effusions. 54 61
2331910 1990
33
Anti-inflammatory and anti-arthritic activity in extract from the leaves of Eriobotrya japonica. 61
31770567 2020
34
Mechanisms involved in the antinociceptive and anti-inflammatory effects of a new triazole derivative: 5-[1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl]-1H-tetrazole (LQFM-096). 61
32030603 2020
35
Phase II study of ramucirumab and docetaxel for previously treated non-small cell lung cancer patients with malignant pleural effusion: Protocol of PLEURAM study. 61
31851428 2020
36
Pleural fluid ADA activity in tuberculous pleurisy can be low in elderly, critically ill patients with multi-organ failure. 61
31937286 2020
37
Childhood pneumonia, pleurisy and lung function: a cohort study from the first to sixth decade of life. 61
31666389 2020
38
Serial anti-tuberculous immune responses during the follow-up of patients with tuberculous pleurisy. 61
31914015 2020
39
Intrapleural urokinase directly under medical thoracoscopy for the diagnosis of tuberculous pleurisy. 61
31719986 2020
40
Pleural cryobiopsy during local anaesthetic thoracoscopy in dry pleural dissemination. 61
31788311 2020
41
Anti-inflammatory activity of the epicuticular wax and its isolated compounds catechin and gallocatechin from Eugenia brasiliensis Lam. (Myrtaceae) leaves. 61
31913074 2020
42
Cyclic AMP Regulates Key Features of Macrophages via PKA: Recruitment, Reprogramming and Efferocytosis. 61
31935860 2020
43
Indwelling pleural catheters for non-malignant pleural effusions: report on a single centre's 10 years of experience. 61
31958272 2020
44
Antinociceptive and anti-inflammatory effect of Poincianella pyramidalis (Tul.) L.P. Queiroz. 61
31931158 2020
45
Osteosarcoma mimicking fibrous pleurisy with dystrophic calcification!!! 61
31898628 2020
46
Cell-free Mycobacterium tuberculosis DNA test in pleural effusion for tuberculous pleurisy: a diagnostic accuracy study. 61
31805377 2019
47
Curine Inhibits Macrophage Activation and Neutrophil Recruitment in a Mouse Model of Lipopolysaccharide-Induced Inflammation. 61
31816942 2019
48
Involvement of the PKA pathway and inhibition of voltage gated Ca2+ channels in antihyperalgesic activity of Lippia grata/β-cyclodextrin. 61
31654745 2019
49
High expression of BTLA and B7-H4 on the surface of myeloid dendritic cells has a negative regulatory effect on their anti-tuberculosis immunity activity in pleural tuberculosis patients. 61
31677529 2019
50
Oxytocin maintains lung histological and functional integrity to confer protection in heat stroke. 61
31804535 2019

Variations for Pleurisy

Expression for Pleurisy

Search GEO for disease gene expression data for Pleurisy.

Pathways for Pleurisy

Pathways related to Pleurisy according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 TNF TLR4 TLR2 SELL MPO MEFV
2
Show member pathways
13.71 TNF TLR4 IL2 IL1RN IFNG CXCL8
3
Show member pathways
13.37 TNF IL2 IL1RN IFNG ICAM1 CXCL8
4
Show member pathways
13.13 TNF TLR4 TLR2 IL2 IFNG CXCL8
5
Show member pathways
12.96 TNF TLR4 TLR2 ICAM1 CXCL8 CCL3
6
Show member pathways
12.86 TNF IL2 IFNG ICAM1 CXCL8
7
Show member pathways
12.83 TNF TLR4 TLR2 IL2 IFNG ICAM1
8
Show member pathways
12.63 TNF TLR4 TLR2 IL2 IFNG
9
Show member pathways
12.63 TNF TLR4 TLR2 IL2 IFNG
10
Show member pathways
12.62 TNF MPO IL2 IFNG CCL2
11 12.55 TNF TLR2 MPO IL2 IL1RN IFNG
12
Show member pathways
12.39 TNF TLR2 IFNG CXCL8 CCL2
13
Show member pathways
12.39 TNF IL2 CXCL8 CCL3 CCL2
14
Show member pathways
12.3 TNF TLR4 TLR2 IFNG ALOX5
15
Show member pathways
12.29 TNF TLR4 TLR2 CXCL8
16 12.27 TNF TLR4 MEFV CXCL8 CCL2
17 12.26 TNF TLR4 TLR2 IFNG
18
Show member pathways
12.26 TNF MPO IL2 IFNG ICAM1 CRP
19
Show member pathways
12.25 TNF TLR2 IL1RN CXCL8
20 12.22 TNF TLR4 TLR2 IFNG
21
Show member pathways
12.21 TNF TLR4 TLR2 IFNG CXCL8
22 12.13 TNF IFNG ICAM1 CCL2
23
Show member pathways
12.09 TNF TLR4 TLR2 IL2 IFNG
24
Show member pathways
12.08 TNF TLR4 TLR2 IFNG
25 12.05 TNF TLR4 MEFV IL2 CXCL8 CCL2
26 12.03 TNF SELL MPO IL2 IFNG
27 12.01 TNF ICAM1 CXCL8 CCL2 ALOX5
28 11.99 TNF TLR4 IL2 IFNG ICAM1 CXCL8
29 11.98 TNF TLR4 ICAM1 CXCL8
30 11.97 TNF ICAM1 CXCL8 CCL2
31 11.95 TNF TLR4 TLR2 IFNG CXCL8
32 11.87 IL2 IFNG ICAM1 CXCL8
33 11.85 TLR4 IFNG CXCL8 CCL3
34 11.85 TNF IL2 IFNG CCL3
35
Show member pathways
11.82 TNF IL2 IFNG CXCL8
36 11.8 TNF SELL IL2 IFNG
37 11.77 TNF TLR4 CXCL8
38 11.73 TNF IL2 IL1RN IFNG CCL3 CCL2
39 11.71 TNF CXCL8 CCL3 CCL2
40
Show member pathways
11.71 TNF IL2 IFNG ICAM1 CXCL8
41
Show member pathways
11.67 TNF IL2 IFNG
42 11.64 TNF TLR4 TLR2 CXCL8
43 11.59 TNF IL2 IFNG
44 11.56 TNF IL2 IFNG
45 11.56 TNF TLR4 TLR2 IFNG CCL2
46 11.55 TNF MPO ICAM1
47 11.51 IFNG ICAM1 CXCL8
48 11.42 TNF IFNG ICAM1
49 11.42 TNF IL1RN ICAM1 CXCL8 CCL3 CCL2
50 11.31 TNF IL2 IFNG

GO Terms for Pleurisy

Cellular components related to Pleurisy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF MPO LCN1 IL2 IL1RN IFNG
2 external side of plasma membrane GO:0009897 9.55 TNF TLR4 SELL ICAM1 ADA
3 extracellular space GO:0005615 9.5 TNF MPO LCN1 IL2 IL1RN IFNG

Biological processes related to Pleurisy according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 10.1 TLR2 SELL MPO ALOX5 ADA2
2 positive regulation of gene expression GO:0010628 10.03 TNF TLR4 TLR2 IFNG CRP CCL3
3 response to lipopolysaccharide GO:0032496 9.96 TLR4 TLR2 MPO ICAM1
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 TNF TLR4 TLR2 ICAM1
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.95 TNF TLR4 ICAM1 CCL3 CCL2
6 cellular response to tumor necrosis factor GO:0071356 9.94 ICAM1 CXCL8 CCL3 CCL2
7 immune response GO:0006955 9.91 TNF TLR4 TLR2 IL2 IL1RN IFNG
8 cellular response to lipopolysaccharide GO:0071222 9.88 TNF TLR4 IL1RN ICAM1 CXCL8 CCL2
9 chemokine-mediated signaling pathway GO:0070098 9.86 CXCL8 CCL3 CCL2
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.86 TNF IL2 IFNG
11 cellular response to organic cyclic compound GO:0071407 9.85 TNF CCL3 CCL2
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR4 TLR2
13 humoral immune response GO:0006959 9.85 TNF IFNG CCL2
14 positive regulation of tumor necrosis factor production GO:0032760 9.84 TLR4 TLR2 CCL3
15 neutrophil chemotaxis GO:0030593 9.84 IL1RN CXCL8 CCL3 CCL2
16 positive regulation of interferon-gamma production GO:0032729 9.83 TNF TLR4 IL2
17 cellular response to interleukin-1 GO:0071347 9.83 ICAM1 CXCL8 CCL3 CCL2
18 positive regulation of inflammatory response GO:0050729 9.83 TNF TLR4 TLR2 IL2 CCL3
19 positive regulation of B cell proliferation GO:0030890 9.82 TLR4 IL2 ADA
20 protein kinase B signaling GO:0043491 9.82 TNF CCL3 CCL2
21 positive regulation of interleukin-6 secretion GO:2000778 9.81 TNF TLR4 TLR2
22 cellular response to interferon-gamma GO:0071346 9.8 TLR4 TLR2 ICAM1 EPRS1 CCL3 CCL2
23 microglial cell activation GO:0001774 9.79 TNF TLR2 IFNG
24 positive regulation of interleukin-8 production GO:0032757 9.78 TNF TLR4 TLR2
25 positive regulation of interleukin-6 production GO:0032755 9.78 TNF TLR4 TLR2 IL1RN
26 positive regulation of interleukin-12 production GO:0032735 9.77 TLR4 TLR2 IFNG
27 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 TNF TLR4 IFNG ICAM1
28 positive regulation of chemokine biosynthetic process GO:0045080 9.7 TNF IFNG
29 negative regulation of amyloid-beta clearance GO:1900222 9.7 TNF IFNG
30 cellular response to lipoteichoic acid GO:0071223 9.69 TLR4 TLR2
31 positive regulation of MHC class II biosynthetic process GO:0045348 9.69 TLR4 IFNG
32 positive regulation of chemokine production GO:0032722 9.69 TNF TLR4 TLR2
33 negative regulation of lipid storage GO:0010888 9.68 TNF CRP
34 positive regulation of NMDA glutamate receptor activity GO:1904783 9.67 IFNG CCL2
35 astrocyte cell migration GO:0043615 9.67 CCL3 CCL2
36 embryonic digestive tract development GO:0048566 9.67 TNF CXCL8 ADA
37 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 TLR4 TLR2 IFNG CCL2
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 TNF IFNG
39 inosine biosynthetic process GO:0046103 9.62 ADA2 ADA
40 adenosine catabolic process GO:0006154 9.62 ADA2 ADA
41 positive regulation of matrix metallopeptidase secretion GO:1904466 9.59 TLR4 TLR2
42 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.58 TLR4 TLR2
43 positive regulation of vitamin D biosynthetic process GO:0060557 9.58 TNF IFNG
44 positive regulation of nitrogen compound metabolic process GO:0051173 9.57 TNF IFNG
45 cytokine-mediated signaling pathway GO:0019221 9.56 TNF IL2 IL1RN ICAM1 CXCL8 CCL3
46 lipopolysaccharide-mediated signaling pathway GO:0031663 9.55 TNF TLR4 TLR2 CCL3 CCL2
47 inflammatory response GO:0006954 9.32 TNF TLR4 TLR2 MEFV IL1RN CXCL8

Molecular functions related to Pleurisy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.91 TNF TLR4 TLR2 MEFV EPRS1 CRP
2 chemokine activity GO:0008009 9.43 CXCL8 CCL3 CCL2
3 adenosine deaminase activity GO:0004000 9.4 ADA2 ADA
4 deaminase activity GO:0019239 9.32 ADA2 ADA
5 cytokine activity GO:0005125 9.17 TNF IL2 IL1RN IFNG CXCL8 CCL3
6 glycosphingolipid binding GO:0043208 9.16 SELL IL2
7 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2

Sources for Pleurisy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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