MCID: PLR005
MIFTS: 33

Pleuropneumonia

Categories: Respiratory diseases

Aliases & Classifications for Pleuropneumonia

MalaCards integrated aliases for Pleuropneumonia:

Name: Pleuropneumonia 12 44 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:14319
MeSH 44 D011001
SNOMED-CT 67 60485005
UMLS 70 C0032241

Summaries for Pleuropneumonia

Disease Ontology : 12 A pneumonia accompanied by inflammation of the pleura and accumulation of pus in the pleural space caused by bacteria.

MalaCards based summary : Pleuropneumonia is related to viral hemorrhagic fever and urethritis. An important gene associated with Pleuropneumonia is GGT1 (Gamma-Glutamyltransferase 1). The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, neutrophil and skin.

Wikipedia : 73 Pleuropneumonia, a protozoa is inflammation of the lungs and pleura, pleurisy being the inflammation of... more...

Related Diseases for Pleuropneumonia

Diseases related to Pleuropneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 viral hemorrhagic fever 10.9
2 urethritis 10.4
3 disease by infectious agent 10.2
4 pleural empyema 10.2
5 pneumonia 10.2
6 bronchopneumonia 10.2
7 vasculitis 10.2
8 pleurisy 10.1
9 bacterial infectious disease 10.1
10 pericarditis 10.1
11 haemophilus influenzae 10.1
12 toxic shock syndrome 10.0
13 pneumothorax 10.0
14 rhinitis 10.0
15 atrophic rhinitis 10.0
16 salpingitis 10.0
17 peritonitis 10.0
18 bacterial pneumonia 10.0
19 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
20 mastitis 9.9
21 plica syndrome 9.9
22 synovitis 9.9
23 purpura 9.9
24 arthropathy 9.9
25 appendicitis 9.9
26 meningitis 9.9
27 pfeiffer syndrome 9.8
28 diaphragmatic hernia, congenital 9.8
29 keratitis, hereditary 9.8
30 otitis media 9.8
31 pneumothorax, primary spontaneous 9.8
32 rheumatoid arthritis 9.8
33 sarcoidosis 1 9.8
34 triiodothyronine receptor auxiliary protein 9.8
35 rheumatic fever-related antigen 9.8
36 ataxia and polyneuropathy, adult-onset 9.8
37 leukemia, acute lymphoblastic 9.8
38 proteinuria, chronic benign 9.8
39 swine influenza 9.8
40 diffuse large b-cell lymphoma 9.8
41 hemorrhagic cystitis 9.8
42 lymphoma 9.8
43 colitis 9.8
44 lung abscess 9.8
45 erythema nodosum 9.8
46 trypanosomiasis 9.8
47 meningoencephalitis 9.8
48 meningocele 9.8
49 hydrocephalus 9.8
50 pasteurellosis 9.8

Graphical network of the top 20 diseases related to Pleuropneumonia:



Diseases related to Pleuropneumonia

Symptoms & Phenotypes for Pleuropneumonia

Drugs & Therapeutics for Pleuropneumonia

Drugs for Pleuropneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 447043 55185
3
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
8
Ofloxacin Approved Phase 4 82419-36-1 4583
9
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
10
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
11
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
12
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
13 Anti-Inflammatory Agents Phase 4
14 Antibiotics, Antitubercular Phase 4
15 Anti-Bacterial Agents Phase 4
16 Antimalarials Phase 4
17 Antiparasitic Agents Phase 4
18 Anti-Infective Agents Phase 4
19 Antiprotozoal Agents Phase 4
20 Methylprednisolone Acetate Phase 4
21 Hormone Antagonists Phase 4
22 Hormones Phase 4
23 Antineoplastic Agents, Hormonal Phase 4
24 glucocorticoids Phase 4
25 Cytochrome P-450 Enzyme Inhibitors Phase 4
26
Acetaminophen Approved 103-90-2 1983
27
Ibuprofen Approved 15687-27-1 3672
28
Cefuroxime Approved 55268-75-2 5361202 5479529
29
Moxifloxacin Approved, Investigational 354812-41-2, 151096-09-2 152946
30 Analgesics, Non-Narcotic
31 Analgesics
32 Antirheumatic Agents
33 Cyclooxygenase Inhibitors
34 Anti-Inflammatory Agents, Non-Steroidal
35 Antipyretics
36 Antibodies, Anti-Idiotypic
37 cefuroxime axetil
38 Cephalosporins
39 Norgestimate, ethinyl estradiol drug combination
40 Immunologic Factors
41 Vaccines
42 Immunoglobulins
43 Antibodies
44 Gastrointestinal Agents
45 Neuroprotective Agents
46 Protective Agents
47 Antiemetics

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Individualizing Duration of Antibiotic Therapy in Hospitalized Patients With Community - Acquired Pneumonia: a Non-inferiority, Randomized, Controlled Trial. Unknown status NCT01492387 Phase 4
2 Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia With Lobar Consolidation or Pleural Effusion in Children Unknown status NCT02618057 Phase 4 Prednisolone;Levofloxacin
3 Study of Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Antibiotic Treatment Unknown status NCT01661985 Phase 4 Azithromycin;Doxycycline;lymecycline
4 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
5 CSP #475 - Persian Gulf - Antibiotic Treatment Trial of Gulf War Veterans' Illnesses Completed NCT00007735 Phase 3 Doxycycline (200mg/day) or Placebo
6 The Role of Non Steroidal Anti Inflammatory Drugs in the Treatment of Pleuropneumonia in Children. a Randomized Controlled Trial Unknown status NCT01586299 Ibuprofen;Acetaminophen
7 Evaluation of a Diagnostic Kit for the Detection of Serum Antibodies Anti Genital Mycoplasma in High Risk Pregnant Women Unknown status NCT01281319
8 Prevalence and Clinical Significance of Co-infection of Mycoplasma Pneumoniae in Patients With Pulmonary Tuberculosis Unknown status NCT00926601
9 The Role of Adaptive Immune Responses to Mycoplasma Pneumoniae in Pathogenesis and Diagnosis of Community-acquired Pneumonia (CAP) in Children: an Observational Single-center Study (myCAP Study) Completed NCT03613636
10 A Double-Blind, Randomized Placebo-Controlled Trial of Doxycycline for Chemoprophylaxis in the Setting of an Outbreak of Mycoplasma Pneumoniae Completed NCT00207584 Doxycycline treatment
11 Clinical Trial Protocol for the Illumigene® Mycoplasma Direct Assay Completed NCT02511262
12 Low Dose Versus High Dose Methylprednisolone for Children With Severe Mycoplasma Pneumoniae Pneumonia : a Multicenter Randomized Blinded Trial Completed NCT02303587 methylprednisolone
13 Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium by Real-time Multiplex Polymerase Chain Reaction After Pooling Pharyngeal, Anorectal and Urinary Samples, in Men Who Have Sex With Men Completed NCT03568695
14 The Optimization of Mycoplasm Pneumonia Antibiotic Therapy: Multi-centre, Prospective, Randomized Controlled Study Completed NCT01259141 Moxifloxacin;Cephalosporins and azithromycin
15 Prevalence of Chlamydia Pneumoniae and Mycoplasma Pneumoniae in Different Forms of Obstructive Coronary Artery Disease Completed NCT00561028
16 Automated Oxygen Administration in Patients With Hypoxemic Pneumonia and Pleuropneumonia Recruiting NCT03527992
17 Studies on Macrolide-resistant Mycoplasma Pneumoniae in Taiwan- A Randomized Control Trial and MLVA Analysis Recruiting NCT03530319 Doxycycline;Azithromycin
18 Comparison of Current Standard of Care Versus the Australian Guidelines for Management of Mycoplasma Genitalium Infections Among Men Being Treated for Non-gonococcal Urethritis Recruiting NCT03910907 Comparison of two standard of care regimens
19 Diagnosis and Treatment of Mycoplasma Pneumoniae and Vaccine Development Recruiting NCT03911440 Doxycycline;Azithromycin
20 Comparison of Self-taken Penile Meatal Swabs Versus First-catch Urine for the Detection of Chlamydia Trachomatis, Neisseria Gonorrhoeae and Mycoplasma Genitalium Not yet recruiting NCT04244994
21 Multi-center Investigation and Study of Mycoplasma Pneumoniae Infection and Macrolide Drug Resistance in Outpatient and In-hospital Pediatric Acute Respiratory Diseases Illness in China Not yet recruiting NCT04126304 Azithromycin;non-macrolides antibiotics
22 A Prospective, Open-label Trial of Methylprednisolone Pulse Macrolide Therapy for Refractory Mycoplasma Pneumoniae Pneumonia in Children Terminated NCT01217099 methylprednisolone;azithromycin

Search NIH Clinical Center for Pleuropneumonia

Cochrane evidence based reviews: pleuropneumonia

Genetic Tests for Pleuropneumonia

Anatomical Context for Pleuropneumonia

MalaCards organs/tissues related to Pleuropneumonia:

40
Endothelial, Neutrophil, Skin, Lymph Node, Appendix, Bone Marrow, Whole Blood

Publications for Pleuropneumonia

Articles related to Pleuropneumonia:

(show top 50) (show all 1710)
# Title Authors PMID Year
1
Prioritizing smallholder animal health needs in East Africa, West Africa, and South Asia using three approaches: Literature review, expert workshops, and practitioner surveys. 61
33581421 2021
2
IFN-γ-/- mice resist Actinobacillus pleuropneumoniae infection by promoting early lung IL-18 release and PMN-I accumulation. 61
33685942 2021
3
Exposure to Sublethal Ciprofloxacin Induces Resistance to Ciprofloxacin and Cross-Antibiotics, and Reduction of Fitness, Biofilm Formation, and Apx Toxin Secretion in Actinobacillus pleuropneumoniae. 61
33739878 2021
4
Emergence of fatal Mannheimia haemolytica infections in cattle in the Netherlands. 61
33468303 2021
5
A novel MLSA allelic profile 'A15' of Mycoplasma mycoides subsp mycoides in Niger. 61
33570262 2021
6
Sero- and apx-typing of German Actinobacillus pleuropneumoniae field isolates from 2010 to 2019 reveals a predominance of serovar 2 with regular apx-profile. 61
33472678 2021
7
Seroprevalence and Risk Factors of Contagious Bovine Pleuropneumonia in Selected Districts of North Gondar Zone, Ethiopia. 61
33718469 2021
8
Acute fibrinous pleuropneumonia and septicaemia caused by Bibersteinia trehalosi in neonatal calves in New Zealand. 61
32646323 2021
9
Actinobacillus pleuropneumoniae exotoxin ApxI induces cell death via attenuation of FAK through LFA-1. 61
33462305 2021
10
Thoracotomy and Pericardiotomy for Access to the Heart in Horses: Surgical Procedure and Effects on Anesthetic Variables. 61
33349415 2021
11
Caspase-1 inhibitor reduced the lung injury in a mouse model of pleuropneumonia caused by Actinobacillus pleuropneumoniae. 61
33480497 2020
12
Associations between animal and herd management factors, serological response to three respiratory pathogens and pluck lesions in finisher pigs on a farrow-to-finish farm. 61
33292673 2020
13
Mycoplasma bovis Infections in Free-Ranging Pronghorn, Wyoming, USA. 61
33219651 2020
14
Reproduction of contagious bovine pleuropneumonia via aerosol-based challenge with Mycoplasma mycoides subsp. mycoides. 61
33198794 2020
15
Pleuropneumonia resulting from varicella and COVID-19 co-infection in a 10-month-old infant. 61
32933816 2020
16
Seroprevalence and determinants of contagious bovine pleuropneumonia in cattle in Burkina Faso. 61
33230579 2020
17
SpyCatcher-SpyTagged ApxIA Toxoid and the Immune-Modulating Yeast Ghost Shells. 61
33461656 2020
18
A whole-genome worldwide molecular epidemiology approach for contagious caprine pleuropneumonia. 61
33083610 2020
19
Single-dose pharmacokinetics of orally administered metronidazole and intravenously administered imipenem in healthy horses and computer-based simulation of pleural fluid concentrations with multiple dosing. 61
32969731 2020
20
Characteristics of Streptococcus pyogenes Versus Streptococcus pneumoniae Pleural Empyema and Pneumonia With Pleural Effusion in Children. 61
32804461 2020
21
NOD2/c-Jun NH2-Terminal Kinase Triggers Mycoplasma ovipneumoniae-Induced Macrophage Autophagy. 61
32778560 2020
22
[Ultrasonography of the lung in calves]. 61
32855119 2020
23
Polycystic kidney disease concurrent with feline parvovirus and bacterial infections in domestic shorthair cat: a case report. 61
33013278 2020
24
Contagious caprine pleuropneumonia (CCPP): A systematic review and meta-analysis of the prevalence in sheep and goats. 61
33448706 2020
25
Contagious Bovine and Caprine Pleuropneumonia: a research community's recommendations for the development of better vaccines. 61
33580051 2020
26
Baseline analysis of Mycoplasma mycoides subsp. mycoides antigens as targets for a DIVA assay for use with a subunit vaccine for contagious bovine pleuropneumonia. 61
32650780 2020
27
Contagious Bovine Pleuropneumonia: A Comprehensive Overview. 61
32390522 2020
28
Concurrent Infection of Skunk Adenovirus-1, Listeria monocytogenes, and a Regionally Specific Clade of Canine Distemper Virus in One Gray Fox (Urocyon cinereoargenteus) and Concurrent Listeriosis and Canine Distemper in a Second Gray Fox. 61
32708148 2020
29
Recombinant tandem epitope vaccination provides cross protection against Actinobacillus pleuropneumoniae challenge in mice. 61
32642871 2020
30
iTRAQ-based quantitative proteomic analysis of peripheral blood serum in piglets infected with Actinobacillus pleuropneumoniae. 61
32632500 2020
31
Characterization of nontypeable Actinobacillus pleuropneumoniae isolates. 61
32517629 2020
32
Enhancement of Apx Toxin Production in Actinobacillus pleuropneumoniae Serotypes 1, 2, and 5 by Optimizing Culture Condition. 61
32238774 2020
33
A descriptive study of acute outbreaks of respiratory disease in Norwegian fattening pig herds. 61
32580726 2020
34
The Actinobacillus pleuropneumoniae sulfate-binding protein is required for the acquisition of sulfate and methionine, but is not essential for virulence. 61
32456813 2020
35
Prevalence and molecular detection of contagious bovine pleuropneumonia in large ruminants in Punjab, Pakistan. 61
33612797 2020
36
The first isolation and molecular characterization of Mycoplasma capricolum subsp. capripneumoniae Pakistan strain: A causative agent of contagious caprine pleuropneumonia. 61
32601044 2020
37
Non-specific, agar medium-related peaks can result in false positive Mycoplasma alkalescens and Mycoplasma arginini identification by MALDI-TOF MS. 61
32182439 2020
38
The first identification of contagious caprine pleuropneumonia (CCPP) in sheep and goats in Egypt: molecular and pathological characterization. 61
31705356 2020
39
Interleukin-17 mediates lung injury by promoting neutrophil accumulation during the development of contagious caprine pleuropneumonia. 61
32273025 2020
40
[Infectious glomerulonephritis and pleuropneumonia due to Streptococcus pneumoniae. Pediatric clinical case]. 61
32199067 2020
41
The antimicrobial peptide MPX kills Actinobacillus pleuropneumoniae and reduces its pathogenicity in mice. 61
32273013 2020
42
Mycoplasma anserisalpingitidis sp. nov., isolated from European domestic geese (Anser anser domesticus) with reproductive pathology. 61
32068526 2020
43
Construction and immunization with double mutant ΔapxIBD Δpnp forms of Actinobacillus pleuropneumoniae serotypes 1 and 5. 61
32233129 2020
44
Acholeplasma equirhinis sp. nov. isolated from respiratory tract of horse (Equus caballus) and Mycoplasma procyoni sp. nov. isolated from oral cavity of raccoon (Procyon lotor). 61
31828363 2020
45
Candidate genes and gene markers for the resistance to porcine pleuropneumonia. 61
31960078 2020
46
Pyogranulomatous pleuropneumonia caused by Nocardia asiatica in a dog coinfected with canine morbillivirus (canine distemper virus). 61
31573747 2020
47
Efficacy of enteric-coated tilmicosin granules in pigs artificially infected with Actinobacillus pleuropneumoniae serotype 2. 61
31589010 2020
48
Genome-wide screening of lipoproteins in Actinobacillus pleuropneumoniae identifies three antigens that confer protection against virulent challenge. 61
32047221 2020
49
Investigation of acute-phase proteins and cytokines response in goats with contagious caprine pleuropneumonia with special reference to their diagnostic accuracy. 61
33240679 2020
50
Contagious Bovine and Caprine Pleuropneumonia: a research community's recommendations for the development of better vaccines. 61
32728480 2020

Variations for Pleuropneumonia

Expression for Pleuropneumonia

Search GEO for disease gene expression data for Pleuropneumonia.

Pathways for Pleuropneumonia

GO Terms for Pleuropneumonia

Biological processes related to Pleuropneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1-mediated signaling pathway GO:0070498 9.26 IRAK4 IRAK3
2 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.16 IRAK3 FOXJ1
3 negative regulation of interleukin-6 production GO:0032715 8.96 IRAK3 FOXJ1
4 MyD88-dependent toll-like receptor signaling pathway GO:0002755 8.62 IRAK4 IRAK3

Molecular functions related to Pleuropneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oligosaccharide binding GO:0070492 8.62 ITLN2 ITLN1

Sources for Pleuropneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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