MCID: PLX004
MIFTS: 39

Plexopathy

Categories: Neuronal diseases

Aliases & Classifications for Plexopathy

MalaCards integrated aliases for Plexopathy:

Name: Plexopathy 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3688
NCIt 50 C27744
UMLS 73 C1335437

Summaries for Plexopathy

MalaCards based summary : Plexopathy is related to brachial plexus neuropathy and compartment syndrome. An important gene associated with Plexopathy is GBE1 (1,4-Alpha-Glucan Branching Enzyme 1), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Pentoxifylline and Clodronate have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 76 Plexopathy is a disorder affecting a network of nerves, blood vessels, or lymph vessels. The region of... more...

Related Diseases for Plexopathy

Diseases related to Plexopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 brachial plexus neuropathy 32.2 CRLF1 PMP22
2 compartment syndrome 30.1 MB PIK3C2A
3 neuroleptic malignant syndrome 29.8 MB PIK3C2A
4 sciatic neuropathy 29.6 NGF NOTCH1
5 radiation induced brachial plexopathy 12.2
6 sacral plexopathy 12.2
7 radiation-induced plexopathy 12.2
8 breast cancer 10.4
9 neuropathy 10.3
10 ulnar neuropathy 10.2 CAMP PMP22
11 granulomatous myositis 10.2 PIK3C2A SMUG1
12 anterior compartment syndrome 10.2 CAMP PIK3C2A
13 tolosa-hunt syndrome 10.2 NLRP3 SMUG1
14 virus associated hemophagocytic syndrome 10.2 MB PIK3C2A
15 interstitial myocarditis 10.2 MB PIK3C2A
16 glycogen storage disease vii 10.2 GBE1 PIK3C2A
17 creatine phosphokinase, elevated serum 10.2 MB PIK3C2A
18 pericardium disease 10.2 PIK3C2A SMUG1
19 posterior myocardial infarction 10.2 MB PIK3C2A
20 myositis fibrosa 10.2 MB PIK3C2A
21 pericardium cancer 10.2 MB SMUG1
22 gas gangrene 10.2 MB PIK3C2A
23 anuria 10.2 MB PIK3C2A
24 asymmetric motor neuropathy 10.1 ALLC PMP22
25 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.1 MB PIK3C2A
26 dystonia 1, torsion, autosomal dominant 10.1 CAMP NOTCH1
27 hemidystonia 10.1 CAMP SMUG1
28 de quervain disease 10.1 CAMP ESR2
29 horner's syndrome 10.1
30 herpes zoster 10.1
31 secondary hypertrophic osteoarthropathy 10.1 AVP SMUG1
32 intermediate coronary syndrome 10.1 MB PIK3C2A
33 brachial plexus lesion 10.1 CAMP CRLF1 NLRP3
34 coronary artery anomaly 10.1 MB PIK3C2A SMUG1
35 peripheral nervous system disease 10.1
36 peripheral vertigo 10.1 AVP CRLF1
37 vestibular disease 10.1 AVP CRLF1
38 lung cancer 10.0
39 oculomotor nerve paralysis 10.0 AVP CAMP SMUG1
40 third cranial nerve disease 10.0 AVP CAMP SMUG1
41 thymus gland disease 10.0 AMPH SMUG1
42 cerebellopontine angle tumor 10.0 ESR2 PTCRA
43 granulomatous angiitis 10.0 AVP NOTCH1
44 cervical cancer 10.0
45 scoliosis 10.0
46 thrombosis 10.0
47 sarcoma 10.0
48 thoracic outlet syndrome 10.0
49 purpura 10.0
50 radiculopathy 10.0

Graphical network of the top 20 diseases related to Plexopathy:



Diseases related to Plexopathy

Symptoms & Phenotypes for Plexopathy

MGI Mouse Phenotypes related to Plexopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 AMPH AVP CRLF1 EGR3 ESR2 GBE1
2 homeostasis/metabolism MP:0005376 10 AVP EGR3 ESR2 GBE1 MB NGF
3 mortality/aging MP:0010768 10 AMPH AVP CAMP CRLF1 EGR3 ESR2
4 cellular MP:0005384 9.97 CAMP ESR2 GBE1 MB NLRP3 NOTCH1
5 muscle MP:0005369 9.5 EGR3 ESR2 GBE1 MB NGF NOTCH1
6 nervous system MP:0003631 9.36 AMPH AVP CRLF1 EGR3 ESR2 GBE1

Drugs & Therapeutics for Plexopathy

Drugs for Plexopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
2
Clodronate Approved, Investigational, Vet_approved Phase 3 10596-23-3 25419
3
Tocopherol Approved, Investigational Phase 3 1406-66-2 14986
4
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
5 Tocotrienol Investigational Phase 3 6829-55-6
6 Micronutrients Phase 3
7 Phosphodiesterase Inhibitors Phase 3
8 Vasodilator Agents Phase 3
9 Vitamins Phase 3
10 Tocotrienols Phase 3
11 Trace Elements Phase 3
12 Antioxidants Phase 3
13 Protective Agents Phase 3
14 Bone Density Conservation Agents Phase 3,Phase 2
15 Tocopherols Phase 3
16 Platelet Aggregation Inhibitors Phase 3
17 Radiation-Protective Agents Phase 3
18 Free Radical Scavengers Phase 3
19
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
20
Exemestane Approved, Investigational Phase 2 107868-30-4 60198
21
Tamoxifen Approved Phase 2 10540-29-1 2733526
22
Fulvestrant Approved, Investigational Phase 2 129453-61-8 17756771 104741
23
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
24
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5330286 5005498
25 Estrogen Antagonists Phase 2
26 Antineoplastic Agents, Hormonal Phase 2
27 Aromatase Inhibitors Phase 2
28 Selective Estrogen Receptor Modulators Phase 2
29 Hormone Antagonists Phase 2
30 Protein Kinase Inhibitors Phase 2
31 Steroid Synthesis Inhibitors Phase 2
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
33 Estrogen Receptor Modulators Phase 2
34 Hormones Phase 2
35 Estrogens Phase 2
36 Estrogen Receptor Antagonists Phase 2
37
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
38
Carboplatin Approved Phase 1 41575-94-4 10339178 38904 498142
39 Antineoplastic Agents, Phytogenic Phase 1
40 Albumin-Bound Paclitaxel Phase 1
41 Antimitotic Agents Phase 1

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Trial of Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy Completed NCT01291433 Phase 3 Pentoxifylline placebo;Pentoxifylline;Tocopherol acetate;Clodronic Acid;Tocopherol placebo;Clodronate placebo
2 3D Augmented Reality Mirror Visual Feedback Applied to the Treatment of Unilateral Upper Extremity Neuropathic Pain. Completed NCT02582216 Phase 1, Phase 2
3 Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer Completed NCT00960999 Phase 2
4 Radiation Therapy in Treating Women With Early Stage Breast Cancer Recruiting NCT00909909 Phase 2
5 Accelerated Radiation Therapy (ART) to the Breast and Nodal Stations Recruiting NCT02917421 Phase 1, Phase 2
6 Stereotactic Body Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer Active, not recruiting NCT00750269 Phase 1, Phase 2
7 Shorter Course Radiation for the Treatment of Breast Cancer That Has Spread to Lymph Nodes Active, not recruiting NCT02700386 Phase 2
8 Radiation Therapy, Palbociclib, and Hormone Therapy in Treating Breast Cancer Patients With Bone Metastasis Not yet recruiting NCT03691493 Phase 2 Anastrozole;Exemestane;Fulvestrant;Letrozole;Palbociclib;Tamoxifen
9 Hypofractionated Proton Beam Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With Stage II-III Non-Small Cell Lung Cancer Completed NCT02172846 Phase 1 Paclitaxel;Carboplatin
10 Thoracic Outlet Syndrome: Case Reports and Analysis With Ultrasound Imaging Completed NCT01196637
11 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
12 Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple Sclerosis Completed NCT03122873
13 Outcome of 15 Versus 5 Fractions in Adjuvant Breast Radiotherapy in Women Over 65 Years Recruiting NCT03121248 Not Applicable
14 Hypofractionated Radiotherapy in Breast Cancer Recruiting NCT03167359 Not Applicable
15 HBOT Late Radiation Tissue Injury Recruiting NCT02425215
16 Short Course Radiation Therapy in Palliative Treatment of Thoracic Cancer Recruiting NCT03804307 Not Applicable
17 Whole Breast + Lymph Node Irradiation: Prone Compared to Supine Position in 15 or 5 Fractions Recruiting NCT03280719 Not Applicable
18 Palliative Hypofractionated Radiotherapy in Advanced Incurable Breast Cancer Active, not recruiting NCT03511781 Not Applicable

Search NIH Clinical Center for Plexopathy

Genetic Tests for Plexopathy

Anatomical Context for Plexopathy

MalaCards organs/tissues related to Plexopathy:

41
Bone, Lung, Brain, Kidney, Spinal Cord, Prostate, Myeloid

Publications for Plexopathy

Articles related to Plexopathy:

(show top 50) (show all 368)
# Title Authors Year
1
Brachial plexopathy after stereotactic body radiation therapy for apical lung cancer: Dosimetric analysis and preliminary clinical outcomes. ( 29556585 )
2018
2
Delayed diagnosis of traumatic gunshot wound Brown-Sequard-plus syndrome due to associated brachial plexopathy. ( 29844927 )
2018
3
MR neurography in traumatic, non-obstetric paediatric brachial plexopathy. ( 29318427 )
2018
4
The Importance of Imaging to Guide Treatment: Intramuscular Psoas Mass with Lumbosacral Plexopathy. ( 29962645 )
2018
5
Contralateral lumbosacral plexopathy following lumbar microdiscectomy. ( 29373920 )
2018
6
Free functioning gracilis transfer for reanimation of elbow and hand in total traumatic brachial plexopathy in children. ( 29547071 )
2018
7
Varicella zoster lumbosacral plexopathy: a rare cause of lower limb weakness. ( 29914899 )
2018
8
Use of a Total Shoulder Arthroplasty in a Patient with Minimally Painful Severe Glenohumeral Arthritis and a Progressive Plexopathy: A Case Report. ( 29794487 )
2018
9
Brachial plexopathy due to breast cancer metastases: electrophysiological and imaging findings. ( 29546605 )
2018
10
Lead fracture of peripheral nerve stimulator for brachial plexopathy -a case report. ( 30037173 )
2018
11
Primary granulocytic sarcoma presenting as a lumbar plexopathy in a nonleukemic patient. ( 30038120 )
2018
12
Brachial plexopathy in carcinoma of the prostate: An uncommon presentation of a common malignancy. ( 30337786 )
2018
13
Imaging Findings in Patients with Zoster-Associated Plexopathy. ( 28364009 )
2017
14
Muscle training-induced bilateral brachial plexopathy in an adolescent with sporadic hereditary neuropathy with liability to pressure palsies. ( 28948078 )
2017
15
Metastatic Brachial Plexopathy with Brain and Spinal Metastasis in a Case of Recurrent Breast Carcinoma Demonstrated on (18)F-FDG PET/CT. ( 28533639 )
2017
16
Unilateral brachial plexopathy, a rare complication of Mycoplasma pneumoniae infection. ( 29221755 )
2017
17
Hypofractionated Nodal Radiation Therapy for Breast Cancer Was Not Associated With Increased Patient-Reported Arm or Brachial Plexopathy Symptoms. ( 29165285 )
2017
18
Long-term Follow-up of Neonatal Brachial Plexopathy: Psychological and Physical Function in Adolescents and Young Adults. ( 28719549 )
2017
19
Accuracy of MR neurography in the diagnosis of brachial plexopathy. ( 28987674 )
2017
20
Metastatic testicular cancer, a Horner's syndrome and brachial plexopathy. ( 28472531 )
2017
21
Rhabdomyolysis resulting in concurrent Horner's syndrome and brachial plexopathy: a case report. ( 28321484 )
2017
22
Non-surgical treatment of delayed onset brachial plexopathy due to hypertrophic clavicular callus- a case report. ( 28919186 )
2017
23
Brachial Plexopathy After Cervical Spine Surgery. ( 28451486 )
2017
24
Successful Treatment of Brachial Plexopathy Due to Herpes Zoster Infection With Intravenous Immunoglobulin. ( 27879550 )
2017
25
ACR Appropriateness Criteria(Ar) Plexopathy. ( 28473078 )
2017
26
A Lumbosacral Plexopathy Compressed by Huge Uterine Myoma. ( 29076826 )
2017
27
Herpes Zoster Brachial Plexopathy: Direct Steroid Injection. ( 27560523 )
2017
28
Brachial Plexopathy. ( 28498215 )
2017
29
West Nile virus-associated brachial plexopathy. ( 27030459 )
2016
30
Brachial Plexopathy Following Wrist Arthroscopy. ( 26754194 )
2016
31
Cervicothoracic intradural arachnoid cyst with scoliosis and brachial plexopathy. ( 26882854 )
2016
32
Herpetic Brachial Plexopathy: Application of Brachial Plexus Magnetic Resonance Imaging and Ultrasound-Guided Corticosteroid Injection. ( 26829085 )
2016
33
Poster 82 Bilateral Upper Trunk Plexopathy with a Winged Scapula: A Case Report. ( 27672852 )
2016
34
Heralding Extramedullary Blast Crisis: Horner's Syndrome with Brachial Plexopathy in a Patient with Chronic Myelogenous Leukemia. ( 28096817 )
2016
35
Electromyographic Findings in Gracilis Muscle Grafts Used to Augment Elbow Flexion in Traumatic Brachial Plexopathy. ( 27295332 )
2016
36
Subcoracoid bursitis presenting with brachial plexopathy involving the posterior cord. ( 27859366 )
2016
37
A case of relapsing-remitting facial palsy and ipsilateral brachial plexopathy caused by HSV-1. ( 26991053 )
2016
38
Diagnosis and treatment of pain in plexopathy, radiculopathy, peripheral neuropathy and phantom limb pain. Evidence and recommendations from the Italian Consensus Conference on Pain on Neurorehabilitation. ( 27834472 )
2016
39
Lumbar plexopathy secondary to spontaneous large retroperitoneal hematoma. ( 27566499 )
2016
40
Lumbosacral Plexopathy in Pelvic Injury - A Cause of Hip Instability in Acetabular Fractures: A Report of Two Cases. ( 28435565 )
2016
41
Poster 344 Upper Extremity Weakness Due to Bilateral Brachial Plexopathy from Guillain-Barre Syndrome in a Cancer Patient: A Case Report. ( 27673098 )
2016
42
The cause of brachial plexopathy in robot-assisted transaxillary thyroidectomy-A neurophysiological investigation. ( 26774192 )
2016
43
Poster 84 Lumbar Plexopathy Secondary to Psoas Mass: AA Case Report. ( 27672851 )
2016
44
Postoperative Bilateral Brachial Plexopathy in a Diabetic Patient. ( 27084414 )
2016
45
Microscopic polyangiitis complicated with bilateral brachial plexopathy: a case report and review of the literature. ( 26782370 )
2016
46
Early transient radiation-induced brachial plexopathy in locally advanced head and neck cancer. ( 27095943 )
2016
47
Gastroesophageal junction carcinoma and brachial plexopathy: An anatomic explanation via perineural spread. ( 26940157 )
2016
48
Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study. ( 26934119 )
2016
49
Vascularized Thoracodorsal to Suprascapular Nerve Transfer, a Novel Technique to Restore Shoulder Function in Partial Brachial Plexopathy. ( 27014699 )
2016
50
Interrater reliability of electrodiagnosis in neonatal brachial plexopathy. ( 27191660 )
2016

Variations for Plexopathy

Expression for Plexopathy

Search GEO for disease gene expression data for Plexopathy.

Pathways for Plexopathy

Pathways related to Plexopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 AVP EGR3 NGF NOTCH1
2 11.34 AVP ESR2 NGF

GO Terms for Plexopathy

Biological processes related to Plexopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane organization GO:0061024 9.33 AMPH AVP PIK3C2A
2 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.32 EGR3 NOTCH1
3 positive regulation of Ras protein signal transduction GO:0046579 9.26 NGF NOTCH1
4 cellular response to peptidoglycan GO:0071224 8.96 CAMP NLRP3
5 peripheral nervous system development GO:0007422 8.8 EGR3 NGF PMP22

Sources for Plexopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....