MCID: PLX004
MIFTS: 29

Plexopathy

Categories: Neuronal diseases

Aliases & Classifications for Plexopathy

MalaCards integrated aliases for Plexopathy:

Name: Plexopathy 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3688
NCIt 50 C27744
UMLS 70 C1335437

Summaries for Plexopathy

MalaCards based summary : Plexopathy is related to brachial plexus neuropathy and mononeuropathy. An important gene associated with Plexopathy is AMPH (Amphiphysin). The drugs Pentoxifylline and Clodronate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, myeloid and brain.

Wikipedia : 73 Plexopathy is a disorder of the network of nerves in the brachial or lumbosacral plexus. Symptoms... more...

Related Diseases for Plexopathy

Diseases related to Plexopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 257)
# Related Disease Score Top Affiliating Genes
1 brachial plexus neuropathy 31.6 SEPTIN9 PMP22 DCAF8
2 mononeuropathy 30.5 PMP22 DCAF8
3 neuritis 30.1 SEPTIN9 PMP22 DPYSL5
4 peripheral nervous system disease 30.1 PMP22 DPYSL5 DCAF8
5 amyotrophic neuralgia 30.0 SEPTIN9 PMP22 DCAF8
6 neuropathy 29.9 SEPTIN9 PMP22 GBE1 DCAF8
7 myelitis 29.7 DPYSL5 AMPH
8 neuromuscular disease 29.3 PMP22 MB DCAF8 AMPH
9 radiation induced brachial plexopathy 11.2
10 sacral plexopathy 11.2
11 radiation-induced plexopathy 11.0
12 radiculopathy 10.3
13 herpes zoster 10.2
14 horner's syndrome 10.2
15 paresthesia 10.2
16 median neuropathy 10.2 PMP22 DCAF8
17 mononeuritis of upper limb and mononeuritis multiplex 10.2 PMP22 DCAF8
18 chickenpox 10.2
19 cerebellopontine angle meningioma 10.2 DPYSL5 AMPH
20 vascular myelopathy 10.2 DPYSL5 AMPH
21 peroneal nerve paralysis 10.2 PMP22 MB
22 partial optic atrophy 10.2 DPYSL5 AMPH
23 anal spasm 10.2 DPYSL5 AMPH
24 anterograde amnesia 10.2 DPYSL5 AMPH
25 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.1
26 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.1
27 thoracic outlet syndrome 10.1
28 brachial plexus lesion 10.1
29 hereditary neuropathies 10.1
30 lingual-facial-buccal dyskinesia 10.1 DPYSL5 AMPH
31 autoimmune disease of peripheral nervous system 10.1 DPYSL5 AMPH
32 stiff-person syndrome 10.1 DPYSL5 AMPH
33 exanthem 10.1
34 limbic encephalitis 10.1 DPYSL5 AMPH
35 neuromuscular junction disease 10.1 DPYSL5 AMPH
36 breast cancer 10.1
37 vasculitis 10.1
38 aneurysm 10.1
39 thymus gland disease 10.1 DPYSL5 AMPH
40 thymus cancer 10.1 DPYSL5 AMPH
41 motor peripheral neuropathy 10.1 PMP22 DCAF8
42 spinal cord disease 10.0 DPYSL5 AMPH
43 neuropathy, hereditary, with liability to pressure palsies 10.0
44 foot drop 10.0
45 hyperekplexia 10.0 DPYSL5 DCAF8 AMPH
46 seizures, benign familial neonatal, 1 10.0
47 cervical cancer 10.0
48 scoliosis 10.0
49 sarcoma 10.0
50 polyneuropathy 10.0

Graphical network of the top 20 diseases related to Plexopathy:



Diseases related to Plexopathy

Symptoms & Phenotypes for Plexopathy

Drugs & Therapeutics for Plexopathy

Drugs for Plexopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
2
Clodronate Approved, Investigational, Vet_approved Phase 3 10596-23-3 25419
3
Tocopherol Approved, Investigational Phase 3 1406-66-2
4
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
5 Tocotrienol Investigational Phase 3 6829-55-6
6 Micronutrients Phase 3
7 Trace Elements Phase 3
8 Vasodilator Agents Phase 3
9 Nutrients Phase 3
10 Phosphodiesterase Inhibitors Phase 3
11 Antioxidants Phase 3
12 Protective Agents Phase 3
13 Platelet Aggregation Inhibitors Phase 3
14 Radiation-Protective Agents Phase 3
15 Tocotrienols Phase 3
16 Vitamins Phase 3
17 Tocopherols Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial Evaluating Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy: the PENTOCLO Trial Completed NCT01291433 Phase 3 Pentoxifylline placebo;Pentoxifylline;Tocopherol acetate;Clodronic Acid;Tocopherol placebo;Clodronate placebo
2 Hip Abductor Muscle Dysfunction After Nailing of Proximal Femoral Fractures, Incidence and Contributing Factors. Recruiting NCT04311892

Search NIH Clinical Center for Plexopathy

Genetic Tests for Plexopathy

Anatomical Context for Plexopathy

MalaCards organs/tissues related to Plexopathy:

40
Spinal Cord, Myeloid, Brain, Lung, Thyroid, Thymus, Kidney

Publications for Plexopathy

Articles related to Plexopathy:

(show top 50) (show all 1029)
# Title Authors PMID Year
1
Parsonage-turner syndrome associated with SARS-CoV2 (COVID-19) infection. 61
33190028 2021
2
Combine contrast-enhanced 3D T2-weighted short inversion time inversion recovery MR neurography with MR angiography at 1.5 T in the assessment of brachial plexopathy. 61
32661842 2021
3
Pulsed Radiofrequency Ablation: An Alternative Treatment Modality for Radiation-Induced Brachial Plexopathy. 61
33164080 2021
4
Teaching Video NeuroImages: Choreoathetosis Due to Radiation-Induced Brachial Plexopathy. 61
32928979 2021
5
Endoscopic Posterior Approach for Cervicothoracic and Upper Thoracic Foraminotomies: 2-Dimensional Operative Video. 61
33694363 2021
6
Nerve Compression Injuries After Prolonged Prone Position Ventilation in Patients With SARS-CoV-2: A Case Series. 61
33245939 2021
7
Percutaneous cryoablation for advanced and refractory extra-abdominal desmoid tumors. 61
33709291 2021
8
Brachial plexopathy as a complication of COVID-19. 61
33766961 2021
9
Severe brachial plexopathy secondary to shingles (herpes zoster). 61
33765117 2021
10
Lumbosacral Radiculoplexus Neuropathy: Neurological Outcomes and Survival in a Population-based Study. 61
33653898 2021
11
Postoperative lumbar paraspinal compartment syndrome. 61
33782060 2021
12
Shear wave elastography evaluation of brachial plexus in multiple sclerosis. 61
33730859 2021
13
Radiation-Induced Brachial Plexopathy in Patients With Breast Cancer Treated With Comprehensive Adjuvant Radiation Therapy. 61
33665488 2021
14
The relationship between alexithymia, sensory phenotype and neurophysiological parameters in patients with chronic upper limb neuropathy. 61
33315145 2021
15
Paraplegia Following Type B Acute Aortic Dissection Can Spare the Spinal Cord. 61
32927034 2021
16
Brachial plexopathy as a consequence of nerve root swelling after shoulder trauma in a patient following an acute seizure. 61
33686840 2021
17
Prognostic Factors Associated With Surviving Less Than 3 Months vs Greater Than 3 Years Specific to Spine Stereotactic Body Radiotherapy and Late Adverse Events. 61
33475723 2021
18
Perineural spread to the brachial plexus: a focused review of proposed mechanisms and described pathologies. 61
32632655 2020
19
Severe Post-Herpetic Lumbar Plexopathy Responds to Pulse Intravenous Methylprednisolone: A Case Report With a Side Note on its Parallel Semiology to Diabetic Radiculoplexopathy and the Vascular Invasiveness of the Varicella-Zoster Virus. 61
33489582 2020
20
Radiation-induced Lumbosacral Plexopathy after Spine Stereotactic Body Radiotherapy - Should the Lumbosacral Plexi be Contoured? 61
33082091 2020
21
Infectious Brachial Plexopathy and Septic Arthritis of the Shoulder due to Lemierre's Syndrome: A Case Report and Literature Review. 61
33439602 2020
22
Metastatic brachial plexopathy as the initial manifestation of breast cancer. 61
33089592 2020
23
Zoster Brachial Plexopathy as a Presenting Manifestation of Human Immunodeficiency Virus Infection. 61
33688132 2020
24
Upper trunk brachial plexopathy as a consequence of prone positioning due to SARS-CoV-2 acute respiratory distress syndrome. 61
32875575 2020
25
A Rare Case of Disseminated Coccidioidomycosis Presenting as Brachial Plexopathy. 61
33178544 2020
26
Isolated Mononeuropathy From Rucksack Palsy: A Case Series. 61
33231605 2020
27
[Lower trunk brachial plexopathy due to hematoma following median sternotomy: a case report]. 61
33115990 2020
28
Lumbosacral plexopathy secondary to discectomy and fixation. 61
33100029 2020
29
Post-Herpetic Brachial Plexopathy: A Rare Case Report With a Side Note on Localizing Brachial Plexopathies and a Literature Review of Post-Herpetic Segmental Paresis. 61
33150099 2020
30
Delayed onset radiation-induced brachial plexopathy. 61
32535991 2020
31
Anatomy, Imaging, and Pathologic Conditions of the Brachial Plexus. 61
33001787 2020
32
Acute Herpes Zoster Radiculopathy of the Lower Extremity With Dermatomal Rash and Lumbar Nerve Enhancement on MRI. 61
33083710 2020
33
The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. 61
32637987 2020
34
A Systematic Review of Peripheral Neuropathies in Breast Cancer-Related Lymphedema. 61
33073616 2020
35
Neurological and Dexterity Assessments in a Woman with Radiation-Induced Brachial Plexopathy After Breast Cancer. 61
32525604 2020
36
Discovering Pathologies in the Anatomy Lab: The Case of Brachial Plexopathy Mimicking Neurological Thoracic Outlet Syndrome. 61
33655186 2020
37
Halo Femoral Traction for 1 Week Between Staged Anterior and Posterior Fusion Surgeries for Severe Adolescent Scoliosis Is Effective and Safe. 61
32585379 2020
38
Neurolymphomatosis, a rare manifestation of peripheral nerve involvement in lymphomas: Suggestive features and diagnostic challenges. 61
32627254 2020
39
Neurological misdiagnoses of lymphoma. 61
32974798 2020
40
Treatment of radiation-induced brachial plexopathy with omentoplasty. 61
33344306 2020
41
Perineural Spread of Clear Cell Adenocarcinoma of Müllerian Origin Resulting in Neoplastic Lumbosacral Plexopathy. 61
32592970 2020
42
Early postoperative complications after Latarjet procedure: a single-institution experience over 10 years. 61
33010440 2020
43
Isolated Musculocutaneous Neuropathy Secondary to an Immune-Mediated Brachial Plexopathy: A Case Report of a Rare Phenotype With a Side Note on Patterns of Weakness and an Update on Nerve Pathology. 61
33042705 2020
44
Primary cancer location predicts predominant level of brachial plexopathy. 61
32511769 2020
45
The Adipofascial Deltopectoral Flap to Cover the Brachial Plexus in Thoracic Outlet Syndrome and Radiation Plexitis. 61
32467081 2020
46
Contralateral lumbosacral plexopathy following lumbar microdiscectomy. 61
29373920 2020
47
Axillary Artery Dissection and Thrombosis after Closed Proximal Humerus Fracture - a Rare Interdisciplinary Challenge. 61
31525793 2020
48
Teaching NeuroImages: Slowly progressive hypertrophic brachial plexopathy due to SEPT9 mutation. 61
32522797 2020
49
Malignant synovial sarcoma: An unpredictable cause of brachial plexopathy. 61
32197143 2020
50
Late-term effects of hypofractionated chest wall and regional nodal radiotherapy with two-dimensional technique in patients with breast cancer. 61
33012154 2020

Variations for Plexopathy

Expression for Plexopathy

Search GEO for disease gene expression data for Plexopathy.

Pathways for Plexopathy

GO Terms for Plexopathy

Sources for Plexopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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