MCID: PLX004
MIFTS: 39

Plexopathy

Categories: Neuronal diseases

Aliases & Classifications for Plexopathy

MalaCards integrated aliases for Plexopathy:

Name: Plexopathy 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3688
NCIt 51 C27744
UMLS 74 C1335437

Summaries for Plexopathy

MalaCards based summary : Plexopathy is related to brachial plexus neuropathy and peripheral nervous system disease. An important gene associated with Plexopathy is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways is Neuroscience. The drugs Clodronate and Pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and lymph node, and related phenotypes are mortality/aging and homeostasis/metabolism

Wikipedia : 77 Plexopathy is a disorder affecting a network of nerves, blood vessels, or lymph vessels. The region of... more...

Related Diseases for Plexopathy

Diseases related to Plexopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 brachial plexus neuropathy 32.3 CRLF1 PMP22
2 peripheral nervous system disease 30.2 NFASC NGF PMP22
3 sciatic neuropathy 29.5 NGF NOTCH1
4 radiation induced brachial plexopathy 12.3
5 sacral plexopathy 12.2
6 radiation-induced plexopathy 12.2
7 breast cancer 10.4
8 ulnar neuropathy 10.4 CAMP PMP22
9 neuropathy 10.3
10 anterior compartment syndrome 10.3 CAMP PIK3C2A
11 virus associated hemophagocytic syndrome 10.3 MB PIK3C2A
12 granulomatous myositis 10.3 PIK3C2A SMUG1
13 interstitial myocarditis 10.3 MB PIK3C2A
14 tolosa-hunt syndrome 10.2 NLRP3 SMUG1
15 creatine phosphokinase, elevated serum 10.2 MB PIK3C2A
16 de quervain disease 10.2 CAMP ESR2
17 posterior myocardial infarction 10.2 MB PIK3C2A
18 myositis fibrosa 10.2 MB PIK3C2A
19 horner's syndrome 10.2
20 gas gangrene 10.2 MB PIK3C2A
21 chronic inflammatory demyelinating polyradiculoneuropathy 10.2 NFASC PMP22
22 secondary hypertrophic osteoarthropathy 10.1 AVP SMUG1
23 herpes zoster 10.1
24 brachial plexus lesion 10.1 CAMP CRLF1 NLRP3
25 coronary artery anomaly 10.1 MB PIK3C2A SMUG1
26 anuria 10.1 MB PIK3C2A
27 oculomotor nerve paralysis 10.1 AVP CAMP SMUG1
28 third cranial nerve disease 10.1 AVP CAMP SMUG1
29 asymmetric motor neuropathy 10.1 ALLC PMP22
30 demyelinating polyneuropathy 10.1 NFASC NGF PMP22
31 lung cancer 10.0
32 sulfite oxidase deficiency due to molybdenum cofactor deficiency 10.0
33 neuropathy, hereditary, with liability to pressure palsies 10.0
34 cervical cancer 10.0
35 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.0
36 scoliosis 10.0
37 thrombosis 10.0
38 sarcoma 10.0
39 thoracic outlet syndrome 10.0
40 purpura 10.0
41 radiculopathy 10.0
42 myeloid sarcoma 10.0
43 bladder cancer 9.9
44 multiple sclerosis 9.9
45 west nile virus 9.9
46 polyarteritis nodosa, childhood-onset 9.9
47 leukemia 9.9
48 cervical dystonia 9.9
49 henoch-schoenlein purpura 9.9
50 mononeuropathy 9.9

Graphical network of the top 20 diseases related to Plexopathy:



Diseases related to Plexopathy

Symptoms & Phenotypes for Plexopathy

MGI Mouse Phenotypes related to Plexopathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 10.06 AMPH AVP CAMP CRLF1 EGR3 ESR2
2 homeostasis/metabolism MP:0005376 10.03 AVP EGR3 ESR2 GBE1 MB NFASC
3 behavior/neurological MP:0005386 10.02 AMPH AVP CRLF1 EGR3 ESR2 GBE1
4 cellular MP:0005384 10.02 CAMP ESR2 GBE1 MB MTUS1 NLRP3
5 muscle MP:0005369 9.5 EGR3 ESR2 GBE1 MB NGF NOTCH1
6 nervous system MP:0003631 9.36 AMPH AVP CRLF1 EGR3 ESR2 GBE1

Drugs & Therapeutics for Plexopathy

Drugs for Plexopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clodronate Approved, Investigational, Vet_approved Phase 3 10596-23-3 25419
2
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
3
Tocopherol Approved, Investigational Phase 3 1406-66-2 14986
4
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
5 Tocotrienol Investigational Phase 3 6829-55-6
6 Antioxidants Phase 3
7 Vasodilator Agents Phase 3
8 Bone Density Conservation Agents Phase 3,Phase 2
9 Tocopherols Phase 3
10 Free Radical Scavengers Phase 3
11 Nutrients Phase 3
12 Trace Elements Phase 3
13 Vitamins Phase 3
14 Tocotrienols Phase 3
15 Micronutrients Phase 3
16 Platelet Aggregation Inhibitors Phase 3
17 Phosphodiesterase Inhibitors Phase 3
18 Radiation-Protective Agents Phase 3
19 Protective Agents Phase 3
20
Exemestane Approved, Investigational Phase 2 107868-30-4 60198
21
Tamoxifen Approved Phase 2 10540-29-1 2733526
22
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
23
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
24
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
25
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
27 Estrogen Receptor Modulators Phase 2
28 Estrogens Phase 2
29 Antineoplastic Agents, Hormonal Phase 2
30 Hormone Antagonists Phase 2
31 Selective Estrogen Receptor Modulators Phase 2
32 Steroid Synthesis Inhibitors Phase 2
33 Hormones Phase 2
34 Estrogen Antagonists Phase 2
35 Aromatase Inhibitors Phase 2
36 Estrogen Receptor Antagonists Phase 2
37 Protein Kinase Inhibitors Phase 2
38
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
39
Carboplatin Approved Phase 1 41575-94-4 38904 10339178 498142
40 Albumin-Bound Paclitaxel Phase 1
41 Antimitotic Agents Phase 1
42 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Trial of Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy Completed NCT01291433 Phase 3 Pentoxifylline placebo;Pentoxifylline;Tocopherol acetate;Clodronic Acid;Tocopherol placebo;Clodronate placebo
2 3D Augmented Reality Mirror Visual Feedback Applied to the Treatment of Unilateral Upper Extremity Neuropathic Pain. Completed NCT02582216 Phase 1, Phase 2
3 Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer Completed NCT00960999 Phase 2
4 Radiation Therapy in Treating Women With Early Stage Breast Cancer Recruiting NCT00909909 Phase 2
5 Accelerated Radiation Therapy (ART) to the Breast and Nodal Stations Recruiting NCT02917421 Phase 1, Phase 2
6 Radiation Therapy, Palbociclib, and Hormone Therapy in Treating Breast Cancer Patients With Bone Metastasis Recruiting NCT03691493 Phase 2 Anastrozole;Exemestane;Fulvestrant;Letrozole;Palbociclib;Tamoxifen
7 Stereotactic Body Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer Active, not recruiting NCT00750269 Phase 1, Phase 2
8 Shorter Course Radiation for the Treatment of Breast Cancer That Has Spread to Lymph Nodes Active, not recruiting NCT02700386 Phase 2
9 Hypofractionated Proton Beam Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With Stage II-III Non-Small Cell Lung Cancer Completed NCT02172846 Phase 1 Paclitaxel;Carboplatin
10 Thoracic Outlet Syndrome: Case Reports and Analysis With Ultrasound Imaging Completed NCT01196637
11 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
12 Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple Sclerosis Completed NCT03122873
13 Outcome of 15 Versus 5 Fractions in Adjuvant Breast Radiotherapy in Women Over 65 Years Recruiting NCT03121248 Not Applicable
14 Hypofractionated Radiotherapy in Breast Cancer Recruiting NCT03167359 Not Applicable
15 HBOT Late Radiation Tissue Injury Recruiting NCT02425215
16 Short Course Radiation Therapy in Palliative Treatment of Thoracic Cancer Recruiting NCT03804307 Not Applicable
17 Hypofractionated Vs Conventional Fractionated Postmastectomy Radiotherapy for High Risk Breast Cancer Recruiting NCT03856372 Not Applicable
18 Whole Breast + Lymph Node Irradiation: Prone Compared to Supine Position in 15 or 5 Fractions Recruiting NCT03280719 Not Applicable
19 Palliative Hypofractionated Radiotherapy in Advanced Incurable Breast Cancer Active, not recruiting NCT03511781 Not Applicable

Search NIH Clinical Center for Plexopathy

Genetic Tests for Plexopathy

Anatomical Context for Plexopathy

MalaCards organs/tissues related to Plexopathy:

42
Breast, Lung, Lymph Node, Bone, Brain, Kidney, Spinal Cord

Publications for Plexopathy

Articles related to Plexopathy:

(show top 50) (show all 377)
# Title Authors Year
1
Horner's Syndrome as Initial Manifestation of Possible Brachial Plexopathy Neurolymphomatosis. ( 30723449 )
2019
2
Muscle training-induced bilateral brachial plexopathy in an adolescent with sporadic hereditary neuropathy with liability to pressure palsies. ( 30779336 )
2019
3
Kyphosis - A risk factor for positioning brachial plexopathy during spinal surgeries. ( 30898433 )
2019
4
Ischemic Lumbosacral Plexopathy after Extensive Onyx Arterial Embolization for Type 2 Endoleak. ( 30910188 )
2019
5
A case of unilateral polymorphic light eruption in brachial plexopathy. ( 30912126 )
2019
6
Degree of Agreement between Electrodiagnostic Testing and Magnetic Resonance Imaging in the Evaluation of Brachial Plexopathy. ( 30664530 )
2019
7
Current status of magnetic resonance neurography in evaluating patients with brachial plexopathy. ( 30688245 )
2019
8
Traumatic Brachial Plexopathy in Athletes: Current Concepts for Diagnosis and Management of Stingers. ( 30741724 )
2019
9
Reinnervation of Extrinsic Finger Flexors and Brachioradialis 22 and 36 Months Following Traumatic Pan-Brachial Plexopathy: A Case Report. ( 30760136 )
2019
10
Brachial plexopathy after stereotactic body radiation therapy for apical lung cancer: Dosimetric analysis and preliminary clinical outcomes. ( 29556585 )
2018
11
Delayed diagnosis of traumatic gunshot wound Brown-Sequard-plus syndrome due to associated brachial plexopathy. ( 29844927 )
2018
12
MR neurography in traumatic, non-obstetric paediatric brachial plexopathy. ( 29318427 )
2018
13
The Importance of Imaging to Guide Treatment: Intramuscular Psoas Mass with Lumbosacral Plexopathy. ( 29962645 )
2018
14
Contralateral lumbosacral plexopathy following lumbar microdiscectomy. ( 29373920 )
2018
15
Free functioning gracilis transfer for reanimation of elbow and hand in total traumatic brachial plexopathy in children. ( 29547071 )
2018
16
Varicella zoster lumbosacral plexopathy: a rare cause of lower limb weakness. ( 29914899 )
2018
17
Use of a Total Shoulder Arthroplasty in a Patient with Minimally Painful Severe Glenohumeral Arthritis and a Progressive Plexopathy: A Case Report. ( 29794487 )
2018
18
Brachial plexopathy due to breast cancer metastases: electrophysiological and imaging findings. ( 29546605 )
2018
19
Lead fracture of peripheral nerve stimulator for brachial plexopathy -a case report. ( 30037173 )
2018
20
Primary granulocytic sarcoma presenting as a lumbar plexopathy in a nonleukemic patient. ( 30038120 )
2018
21
Brachial plexopathy in carcinoma of the prostate: An uncommon presentation of a common malignancy. ( 30337786 )
2018
22
Imaging Findings in Patients with Zoster-Associated Plexopathy. ( 28364009 )
2017
23
Muscle training-induced bilateral brachial plexopathy in an adolescent with sporadic hereditary neuropathy with liability to pressure palsies. ( 28948078 )
2017
24
Metastatic Brachial Plexopathy with Brain and Spinal Metastasis in a Case of Recurrent Breast Carcinoma Demonstrated on (18)F-FDG PET/CT. ( 28533639 )
2017
25
Unilateral brachial plexopathy, a rare complication of Mycoplasma pneumoniae infection. ( 29221755 )
2017
26
Hypofractionated Nodal Radiation Therapy for Breast Cancer Was Not Associated With Increased Patient-Reported Arm or Brachial Plexopathy Symptoms. ( 29165285 )
2017
27
Long-term Follow-up of Neonatal Brachial Plexopathy: Psychological and Physical Function in Adolescents and Young Adults. ( 28719549 )
2017
28
Accuracy of MR neurography in the diagnosis of brachial plexopathy. ( 28987674 )
2017
29
Metastatic testicular cancer, a Horner's syndrome and brachial plexopathy. ( 28472531 )
2017
30
Rhabdomyolysis resulting in concurrent Horner's syndrome and brachial plexopathy: a case report. ( 28321484 )
2017
31
Non-surgical treatment of delayed onset brachial plexopathy due to hypertrophic clavicular callus- a case report. ( 28919186 )
2017
32
Brachial Plexopathy After Cervical Spine Surgery. ( 28451486 )
2017
33
Successful Treatment of Brachial Plexopathy Due to Herpes Zoster Infection With Intravenous Immunoglobulin. ( 27879550 )
2017
34
ACR Appropriateness Criteria(Ar) Plexopathy. ( 28473078 )
2017
35
A Lumbosacral Plexopathy Compressed by Huge Uterine Myoma. ( 29076826 )
2017
36
Brachial Plexopathy. ( 28498215 )
2017
37
Herpes Zoster Brachial Plexopathy: Direct Steroid Injection. ( 27560523 )
2017
38
West Nile virus-associated brachial plexopathy. ( 27030459 )
2016
39
Brachial Plexopathy Following Wrist Arthroscopy. ( 26754194 )
2016
40
Cervicothoracic intradural arachnoid cyst with scoliosis and brachial plexopathy. ( 26882854 )
2016
41
Herpetic Brachial Plexopathy: Application of Brachial Plexus Magnetic Resonance Imaging and Ultrasound-Guided Corticosteroid Injection. ( 26829085 )
2016
42
Poster 82 Bilateral Upper Trunk Plexopathy with a Winged Scapula: A Case Report. ( 27672852 )
2016
43
Heralding Extramedullary Blast Crisis: Horner's Syndrome with Brachial Plexopathy in a Patient with Chronic Myelogenous Leukemia. ( 28096817 )
2016
44
Electromyographic Findings in Gracilis Muscle Grafts Used to Augment Elbow Flexion in Traumatic Brachial Plexopathy. ( 27295332 )
2016
45
Subcoracoid bursitis presenting with brachial plexopathy involving the posterior cord. ( 27859366 )
2016
46
A case of relapsing-remitting facial palsy and ipsilateral brachial plexopathy caused by HSV-1. ( 26991053 )
2016
47
Diagnosis and treatment of pain in plexopathy, radiculopathy, peripheral neuropathy and phantom limb pain. Evidence and recommendations from the Italian Consensus Conference on Pain on Neurorehabilitation. ( 27834472 )
2016
48
Lumbar plexopathy secondary to spontaneous large retroperitoneal hematoma. ( 27566499 )
2016
49
Lumbosacral Plexopathy in Pelvic Injury - A Cause of Hip Instability in Acetabular Fractures: A Report of Two Cases. ( 28435565 )
2016
50
Poster 344 Upper Extremity Weakness Due to Bilateral Brachial Plexopathy from Guillain-Barre Syndrome in a Cancer Patient: A Case Report. ( 27673098 )
2016

Variations for Plexopathy

Expression for Plexopathy

Search GEO for disease gene expression data for Plexopathy.

Pathways for Plexopathy

Pathways related to Plexopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 AVP EGR3 NFASC NGF NOTCH1

GO Terms for Plexopathy

Biological processes related to Plexopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane organization GO:0061024 9.43 AMPH AVP PIK3C2A
2 positive regulation of Ras protein signal transduction GO:0046579 9.16 NGF NOTCH1
3 cellular response to peptidoglycan GO:0071224 8.96 CAMP NLRP3
4 peripheral nervous system development GO:0007422 8.92 EGR3 NFASC NGF PMP22

Sources for Plexopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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