Aliases & Classifications for Plexopathy

MalaCards integrated aliases for Plexopathy:

Name: Plexopathy 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3688
NCIt 50 C27744
UMLS 73 C1335437

Summaries for Plexopathy

MalaCards based summary : Plexopathy is related to compartment syndrome and sciatic neuropathy. An important gene associated with Plexopathy is SMUG1 (Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Clodronate and Pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 76 Plexopathy is a disorder affecting a network of nerves, blood vessels, or lymph vessels. The region of... more...

Related Diseases for Plexopathy

Diseases related to Plexopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 compartment syndrome 29.9 MB PIK3C2A
2 sciatic neuropathy 29.2 NGF NOTCH1
3 radiation induced brachial plexopathy 12.1
4 sacral plexopathy 12.1
5 brachial plexus neuropathy 11.1
6 ulnar neuropathy 10.7 CAMP PMP22
7 granulomatous myositis 10.6 PIK3C2A SMUG1
8 anterior compartment syndrome 10.6 CAMP PIK3C2A
9 virus associated hemophagocytic syndrome 10.6 MB PIK3C2A
10 tolosa-hunt syndrome 10.5 NLRP3 SMUG1
11 interstitial myocarditis 10.5 MB PIK3C2A
12 nerve compression syndrome 10.5 NOTCH1 PMP22
13 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.5 MB PIK3C2A
14 creatine phosphokinase, elevated serum 10.5 MB PIK3C2A
15 posterior myocardial infarction 10.5 MB PIK3C2A
16 myositis fibrosa 10.5 MB PIK3C2A
17 gas gangrene 10.5 MB PIK3C2A
18 asymmetric motor neuropathy 10.5 ALLC PMP22
19 pericardium cancer 10.4 MB SMUG1
20 anuria 10.4 MB PIK3C2A
21 de quervain disease 10.4 CAMP ESR2
22 neuroleptic malignant syndrome 10.4 MB PIK3C2A
23 dystonia 1, torsion, autosomal dominant 10.3 CAMP NOTCH1
24 secondary hypertrophic osteoarthropathy 10.3 AVP SMUG1
25 brachial plexus lesion 10.2 CAMP CRLF1 NLRP3
26 hemidystonia 10.2 CAMP SMUG1
27 peripheral vertigo 10.2 AVP CRLF1
28 vestibular disease 10.1 AVP CRLF1
29 intermediate coronary syndrome 10.1 MB PIK3C2A
30 neuropathy 10.1
31 cerebellopontine angle tumor 10.1 ESR2 PTCRA
32 oculomotor nerve paralysis 10.0 AVP CAMP SMUG1
33 third cranial nerve disease 10.0 AVP CAMP SMUG1
34 breast cancer 10.0
35 neuropathy, hereditary, with liability to pressure palsies 10.0
36 hereditary neuropathy with liability to pressure palsy 10.0
37 hereditary neuropathies 10.0
38 horner's syndrome 10.0
39 cervicitis 9.9
40 lung cancer 9.8
41 leukemia 9.8
42 cervical dystonia 9.8
43 thrombosis 9.8
44 radiculopathy 9.8
45 dystonia 9.8
46 peripheral nervous system disease 9.8
47 herpes zoster 9.8
48 aneurysm 9.8
49 cervical rib 9.6
50 lipomatosis, multiple symmetric 9.6

Graphical network of the top 20 diseases related to Plexopathy:



Diseases related to Plexopathy

Symptoms & Phenotypes for Plexopathy

MGI Mouse Phenotypes related to Plexopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 EGR3 ESR2 PIK3C2A GBE1 PMP22 AMPH
2 homeostasis/metabolism MP:0005376 10 NOTCH1 ESR2 PIK3C2A GBE1 PMP22 MB
3 mortality/aging MP:0010768 10 ESR2 PIK3C2A GBE1 PMP22 AMPH MB
4 cellular MP:0005384 9.97 NOTCH1 ESR2 PIK3C2A GBE1 PMP22 MB
5 muscle MP:0005369 9.5 EGR3 NOTCH1 ESR2 GBE1 PMP22 MB
6 nervous system MP:0003631 9.36 NOTCH1 ESR2 PIK3C2A GBE1 PMP22 AMPH

Drugs & Therapeutics for Plexopathy

Drugs for Plexopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clodronate Approved, Investigational, Vet_approved Phase 3 10596-23-3 25419
2
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
3
Tocopherol Approved, Investigational, Nutraceutical Phase 3 1406-66-2 14986
4
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
5 Antioxidants Phase 3
6 Bone Density Conservation Agents Phase 3
7 Micronutrients Phase 3
8 Phosphodiesterase Inhibitors Phase 3
9 Platelet Aggregation Inhibitors Phase 3
10 Protective Agents Phase 3
11 Radiation-Protective Agents Phase 3
12 Tocopherols Phase 3
13 Tocotrienols Phase 3
14 Trace Elements Phase 3
15 Vasodilator Agents Phase 3
16 Vitamins Phase 3
17 Tocotrienol Investigational, Nutraceutical Phase 3 6829-55-6
18
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
19
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
20 Albumin-Bound Paclitaxel Phase 1
21 Antimitotic Agents Phase 1
22 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Trial of Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy Completed NCT01291433 Phase 3 Pentoxifylline placebo;Pentoxifylline;Tocopherol acetate;Clodronic Acid;Tocopherol placebo;Clodronate placebo
2 3D Augmented Reality Mirror Visual Feedback Applied to the Treatment of Unilateral Upper Extremity Neuropathic Pain. Completed NCT02582216 Phase 1, Phase 2
3 Radiation Therapy in Treating Women With Early Stage Breast Cancer Recruiting NCT00909909 Phase 2
4 Accelerated Radiation Therapy (ART) to the Breast and Nodal Stations Recruiting NCT02917421 Phase 1, Phase 2
5 Shorter Course Radiation for the Treatment of Breast Cancer That Has Spread to Lymph Nodes Recruiting NCT02700386 Phase 2
6 Stereotactic Body Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer Active, not recruiting NCT00750269 Phase 1, Phase 2
7 Hypofractionated Proton Beam Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With Stage II-III Non-Small Cell Lung Cancer Completed NCT02172846 Phase 1 Paclitaxel;Carboplatin
8 Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer Completed NCT00960999 Not Applicable
9 Thoracic Outlet Syndrome: Case Reports and Analysis With Ultrasound Imaging Completed NCT01196637
10 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
11 Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple Sclerosis Completed NCT03122873
12 Outcome of 15 Versus 5 Fractions in Adjuvant Breast Radiotherapy in Women Over 65 Years Recruiting NCT03121248 Not Applicable
13 Hypofractionated Radiotherapy in Breast Cancer Recruiting NCT03167359 Not Applicable
14 HBOT Late Radiation Tissue Injury Recruiting NCT02425215
15 Whole Breast + Lymph Node Irradiation: Prone Compared to Supine Position in 15 or 5 Fractions Recruiting NCT03280719 Not Applicable
16 Palliative Hypofractionated Radiotherapy in Advanced Incurable Breast Cancer Active, not recruiting NCT03511781 Not Applicable

Search NIH Clinical Center for Plexopathy

Genetic Tests for Plexopathy

Anatomical Context for Plexopathy

MalaCards organs/tissues related to Plexopathy:

41
Lung, Lymph Node, Bone, Myeloid, Testes, Colon, Brain

Publications for Plexopathy

Articles related to Plexopathy:

(show top 50) (show all 116)
# Title Authors Year
1
Brachial plexopathy after stereotactic body radiation therapy for apical lung cancer: Dosimetric analysis and preliminary clinical outcomes. ( 29556585 )
2018
2
Delayed diagnosis of traumatic gunshot wound Brown-Sequard-plus syndrome due to associated brachial plexopathy. ( 29844927 )
2018
3
MR neurography in traumatic, non-obstetric paediatric brachial plexopathy. ( 29318427 )
2018
4
The Importance of Imaging to Guide Treatment: Intramuscular Psoas Mass with Lumbosacral Plexopathy. ( 29962645 )
2018
5
Contralateral lumbosacral plexopathy following lumbar microdiscectomy. ( 29373920 )
2018
6
Free functioning gracilis transfer for reanimation of elbow and hand in total traumatic brachial plexopathy in children. ( 29547071 )
2018
7
Varicella zoster lumbosacral plexopathy: a rare cause of lower limb weakness. ( 29914899 )
2018
8
Use of a Total Shoulder Arthroplasty in a Patient with Minimally Painful Severe Glenohumeral Arthritis and a Progressive Plexopathy: A Case Report. ( 29794487 )
2018
9
Brachial plexopathy due to breast cancer metastases: electrophysiological and imaging findings. ( 29546605 )
2018
10
Imaging Findings in Patients with Zoster-Associated Plexopathy. ( 28364009 )
2017
11
Muscle training-induced bilateral brachial plexopathy in an adolescent with sporadic hereditary neuropathy with liability to pressure palsies. ( 28948078 )
2017
12
Metastatic Brachial Plexopathy with Brain and Spinal Metastasis in a Case of Recurrent Breast Carcinoma Demonstrated on (18)F-FDG PET/CT. ( 28533639 )
2017
13
Unilateral brachial plexopathy, a rare complication of Mycoplasma pneumoniae infection. ( 29221755 )
2017
14
Hypofractionated Nodal Radiation Therapy for Breast Cancer Was Not Associated With Increased Patient-Reported Arm or Brachial Plexopathy Symptoms. ( 29165285 )
2017
15
Long-term Follow-up of Neonatal Brachial Plexopathy: Psychological and Physical Function in Adolescents and Young Adults. ( 28719549 )
2017
16
Accuracy of MR neurography in the diagnosis of brachial plexopathy. ( 28987674 )
2017
17
Metastatic testicular cancer, a Horner's syndrome and brachial plexopathy. ( 28472531 )
2017
18
Rhabdomyolysis resulting in concurrent Horner's syndrome and brachial plexopathy: a case report. ( 28321484 )
2017
19
Non-surgical treatment of delayed onset brachial plexopathy due to hypertrophic clavicular callus- a case report. ( 28919186 )
2017
20
Brachial Plexopathy After Cervical Spine Surgery. ( 28451486 )
2017
21
Successful Treatment of Brachial Plexopathy Due to Herpes Zoster Infection With Intravenous Immunoglobulin. ( 27879550 )
2017
22
ACR Appropriateness Criteria(Ar) Plexopathy. ( 28473078 )
2017
23
A Lumbosacral Plexopathy Compressed by Huge Uterine Myoma. ( 29076826 )
2017
24
Brachial Plexopathy. ( 28498215 )
2017
25
West Nile virus-associated brachial plexopathy. ( 27030459 )
2016
26
Brachial Plexopathy Following Wrist Arthroscopy. ( 26754194 )
2016
27
Cervicothoracic intradural arachnoid cyst with scoliosis and brachial plexopathy. ( 26882854 )
2016
28
Herpetic Brachial Plexopathy: Application of Brachial Plexus Magnetic Resonance Imaging and Ultrasound-Guided Corticosteroid Injection. ( 26829085 )
2016
29
Poster 82 Bilateral Upper Trunk Plexopathy with a Winged Scapula: A Case Report. ( 27672852 )
2016
30
Heralding Extramedullary Blast Crisis: Horner's Syndrome with Brachial Plexopathy in a Patient with Chronic Myelogenous Leukemia. ( 28096817 )
2016
31
Electromyographic Findings in Gracilis Muscle Grafts Used to Augment Elbow Flexion in Traumatic Brachial Plexopathy. ( 27295332 )
2016
32
Subcoracoid bursitis presenting with brachial plexopathy involving the posterior cord. ( 27859366 )
2016
33
A case of relapsing-remitting facial palsy and ipsilateral brachial plexopathy caused by HSV-1. ( 26991053 )
2016
34
Diagnosis and treatment of pain in plexopathy, radiculopathy, peripheral neuropathy and phantom limb pain. Evidence and recommendations from the Italian Consensus Conference on Pain on Neurorehabilitation. ( 27834472 )
2016
35
Lumbar plexopathy secondary to spontaneous large retroperitoneal hematoma. ( 27566499 )
2016
36
Lumbosacral Plexopathy in Pelvic Injury - A Cause of Hip Instability in Acetabular Fractures: A Report of Two Cases. ( 28435565 )
2016
37
Poster 344 Upper Extremity Weakness Due to Bilateral Brachial Plexopathy from Guillain-Barre Syndrome in a Cancer Patient: A Case Report. ( 27673098 )
2016
38
The cause of brachial plexopathy in robot-assisted transaxillary thyroidectomy-A neurophysiological investigation. ( 26774192 )
2016
39
Poster 84 Lumbar Plexopathy Secondary to Psoas Mass: AA Case Report. ( 27672851 )
2016
40
Postoperative Bilateral Brachial Plexopathy in a Diabetic Patient. ( 27084414 )
2016
41
Microscopic polyangiitis complicated with bilateral brachial plexopathy: a case report and review of the literature. ( 26782370 )
2016
42
Early transient radiation-induced brachial plexopathy in locally advanced head and neck cancer. ( 27095943 )
2016
43
Gastroesophageal junction carcinoma and brachial plexopathy: An anatomic explanation via perineural spread. ( 26940157 )
2016
44
Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study. ( 26934119 )
2016
45
Vascularized Thoracodorsal to Suprascapular Nerve Transfer, a Novel Technique to Restore Shoulder Function in Partial Brachial Plexopathy. ( 27014699 )
2016
46
Interrater reliability of electrodiagnosis in neonatal brachial plexopathy. ( 27191660 )
2016
47
Hereditary neuropathy with liability to pressure palsy presenting as a bilateral brachial plexopathy. ( 26874568 )
2016
48
Clinical Utility of (18)F-FDG PET/CT in brachial plexopathy secondary to metastatic breast cancer. ( 27095861 )
2016
49
Poster 1 Incomplete Right Brachial Plexopathy after Segmental Mastectomy for Breast Cancer Resection: A Case Report. ( 27672769 )
2016
50
Combined Spinal Cord Stimulation and Peripheral Nerve Stimulation for Brachial Plexopathy: A Case Report. ( 27008302 )
2016

Variations for Plexopathy

Expression for Plexopathy

Search GEO for disease gene expression data for Plexopathy.

Pathways for Plexopathy

Pathways related to Plexopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 AVP EGR3 NGF NOTCH1
2 11.34 AVP ESR2 NGF

GO Terms for Plexopathy

Biological processes related to Plexopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane organization GO:0061024 9.43 AMPH AVP PIK3C2A
2 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.32 EGR3 NOTCH1
3 positive regulation of Ras protein signal transduction GO:0046579 9.16 NGF NOTCH1
4 cellular response to peptidoglycan GO:0071224 8.96 CAMP NLRP3
5 peripheral nervous system development GO:0007422 8.8 EGR3 NGF PMP22

Sources for Plexopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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