MCID: PLM011
MIFTS: 34

Plummer's Disease

Categories: Endocrine diseases
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Aliases & Classifications for Plummer's Disease

MalaCards integrated aliases for Plummer's Disease:

Name: Plummer's Disease 11 14 75
Toxic Nodular Goiter 11 16 71
Goiter Toxic Nodular 53
Plummer Disease 11

Classifications:



External Ids:

Disease Ontology 11 DOID:11277
ICD9CM 34 242.3
NCIt 49 C35171
SNOMED-CT 68 57777000
ICD10 31 E05.2
UMLS 71 C0342127

Summaries for Plummer's Disease

MalaCards based summary: Plummer's Disease, also known as toxic nodular goiter, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and adenoma. An important gene associated with Plummer's Disease is TG (Thyroglobulin), and among its related pathways/superpathways are G alpha (s) signalling events and Cell adhesion_Cell-matrix glycoconjugates. The drugs Iodine and Cadexomer iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and pituitary, and related phenotypes are hearing/vestibular/ear and endocrine/exocrine gland

Related Diseases for Plummer's Disease

Diseases related to Plummer's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 30.7 TPO TG
2 adenoma 30.2 TSHR TG PTH
3 toxic diffuse goiter 30.2 TSHR TPO TG
4 hypothyroidism, congenital, nongoitrous, 2 30.2 TSHR TG
5 autoimmune disease 30.2 TSHR TPO TG ICAM1
6 hypothyroidism, congenital, nongoitrous, 1 30.1 TSHR TG PTH
7 hypoparathyroidism 30.0 TPO PTH CALCA
8 thyroid crisis 30.0 TSHR TPO TG SERPINA7
9 goiter 29.9 TSHR TPO TG SHBG SERPINA7 CALCA
10 thyroid cancer, nonmedullary, 2 29.9 TSHR TG CALCA
11 suppurative thyroiditis 29.8 TSHR TPO TG CALCA
12 thyroid gland follicular carcinoma 29.8 TSHR TPO TG CALCA
13 parathyroid adenoma 29.8 TG PTH CALCA
14 thyroid hormone resistance, generalized, autosomal dominant 29.8 TSHR TG SHBG SERPINA7
15 follicular adenoma 29.7 TSHR TPO TG CALCA
16 papillary carcinoma 29.7 TSHR TPO TG CALCA
17 thyroiditis 29.6 TSHR TPO TG SERPINA7 CALCA
18 graves disease 1 29.5 TSHR TPO TG SHBG SERPINA7 PTH
19 multinodular goiter 29.5 TSHR TPO TG PTH CALCA
20 hyperthyroidism 29.5 TSHR TPO TG SHBG SERPINA7 PTH
21 nodular goiter 29.4 TSHR TPO TG PTH ICAM1 CALCA
22 hypothyroidism 29.4 TSHR TPO TG SHBG SERPINA7 CALCA
23 thyroid gland cancer 29.3 TSHR TPO TG PTH CALCA
24 nontoxic goiter 29.1 TSHR TPO TG SHBG SERPINA7 PTH
25 hashimoto thyroiditis 29.1 TSHR TPO TG SERPINA7 ICAM1 CALCA
26 endemic goiter 29.1 TSHR TPO TG SERPINA7 PTH CALCA
27 graves' disease 29.0 TSHR TPO TG SERPINA7 SELL SELE
28 mechanical strabismus 10.3 TPO TG
29 hyperglobulinemic purpura 10.3 SELE ICAM1
30 hypothyroidism, congenital, nongoitrous, 4 10.2 TPO TG
31 rheumatoid vasculitis 10.2 SELE ICAM1
32 heterophyiasis 10.2 SELE ICAM1
33 chronic spontaneous urticaria 10.2 TPO TG
34 shwartzman phenomenon 10.2 SELE ICAM1
35 autoimmune gastritis 10.2 TPO TG
36 immunodeficiency 58 10.2 TPO TG
37 hypotropia 10.2 TSHR TPO
38 neonatal thyrotoxicosis 10.2 TSHR TG
39 primary hyperparathyroidism 10.2
40 orbital disease 10.2 TSHR TG
41 adrenal cortical hypofunction 10.2 TPO TG
42 thyroid hormone resistance, selective pituitary 10.2 TG SERPINA7
43 thyroid angiosarcoma 10.2 TG CALCA
44 chronic venous insufficiency 10.2 SELE ICAM1
45 struma ovarii 10.2 TSHR TG
46 spindle epithelial tumor with thymus-like differentiation tumor 10.2 TG CALCA
47 boutonneuse fever 10.2 SELL SELE
48 atypical follicular adenoma 10.2 TG CALCA
49 papillary thyroid microcarcinoma 10.2 TG CALCA
50 arthus reaction 10.2 SELL ICAM1

Graphical network of the top 20 diseases related to Plummer's Disease:



Diseases related to Plummer's Disease

Symptoms & Phenotypes for Plummer's Disease

MGI Mouse Phenotypes related to Plummer's Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.35 CALCA KCNE3 TG TPO TSHR
2 endocrine/exocrine gland MP:0005379 9.17 ICAM1 KCNE3 PTH SELL TG TPO

Drugs & Therapeutics for Plummer's Disease

Drugs for Plummer's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 3 7553-56-2 807
2
Cadexomer iodine Experimental Phase 3 94820-09-4
3 Pharmaceutical Solutions Phase 3
4 Lugol's solution Phase 3
5 Hemostatics Phase 3
6 Coagulants Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter Recruiting NCT04856488 Phase 3 Iodine-Potassium Iodide 5%-10% Oral and Topical Solution
2 The Effect of 0.1 mg Recombinant Human Thyrotropin (rhTSH) on Thyroid Radioiodine-uptake and the Degree of Goiter Reduction Following 131I-therapy, in Patients With Benign Non-toxic Nodular Goiter. A Randomized, Double-blind, Placebo-controlled Trial. Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH

Search NIH Clinical Center for Plummer's Disease

Genetic Tests for Plummer's Disease

Anatomical Context for Plummer's Disease

Organs/tissues related to Plummer's Disease:

MalaCards : Thyroid, Bone, Pituitary, Heart, T Cells, Eye, Endothelial

Publications for Plummer's Disease

Articles related to Plummer's Disease:

(show top 50) (show all 394)
# Title Authors PMID Year
1
Soluble intercellular adhesion molecule-1 concentrations in patients with subacute thyroiditis and in patients with Graves' disease with or without ophthalmopathy. 53 62
8980891 1996
2
Circulating selectins, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in hyperthyroidism. 53 62
7541802 1995
3
Bispecific thyroglobulin and thyroperoxidase autoantibodies in patients with various thyroid and autoimmune diseases. 53 62
7962336 1994
4
The measurement of the serum sex-hormone binding globulin in various thyroid diseases. 53 62
2280997 1990
5
Case report: coexistence of primary hyperparathyroidism with giant toxic nodular goiter. 62
35945539 2022
6
Anti-nuclear autoantibodies in Graves' disease and Graves' orbitopathy. 62
36030301 2022
7
Comparison of thyroid surgery experiences of "East" and "West" regions in Turkiye. 62
36276571 2022
8
Incidence and Risk Factors of Thyroid Malignancy in Patients with Toxic Nodular Goiter. 62
35656410 2022
9
Type 2 Marine-Lenhart Syndrome: An Uncommon Cause of Thyrotoxicosis. 62
35103137 2021
10
Eye symptoms in patients with benign thyroid diseases. 62
34548580 2021
11
Bidirectional association between alopecia areata and thyroid diseases: a nationwide population-based cohort study. 62
32705333 2021
12
Current approach to surgical management of hyperthyroidism. 62
33494587 2021
13
Treatment of Hyperthyroidism Reduces Systemic Oxidative Stress, as Measured by Markers of RNA and DNA Damage. 62
33901280 2021
14
[Nodular toxic goiter in children: clinical features, morphological variants]. 62
34004107 2021
15
Impact of Radioiodine Treatment on Doppler Flow Parameters in the Central Retinal Artery and Ophthalmic Artery in Patients With Hyperthyroidism. 62
32697397 2021
16
[Radioiodine therapy outcome in toxic multinodular goiter patient with concomitant hereditary Hasharon hemoglobinopathy]. 62
33351336 2020
17
Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors. 62
32838791 2020
18
Added value of circulating miRNA expression profiling to sonographic TI-RADS classification in the diagnosis of thyroid nodules. 62
32765676 2020
19
Association of Radioactive Iodine, Antithyroid Drug, and Surgical Treatments With Solid Cancer Mortality in Patients With Hyperthyroidism. 62
32701159 2020
20
A Rare Case of Subacute Painful Thyroiditis Causing Thyroid Storm and a Successful Trial of Propylthiouracil. 62
32760639 2020
21
Effective Preoperative Plasmapheresis Treatment of Severe Hyperthyroidism in a Patient with Giant Toxic Nodular Goiter and Methimazole-Induced Agranulocytosis. 62
32545570 2020
22
Graves' Disease and Toxic Nodular Goiter, Aggravated by Duration of Hyperthyroidism, Are Associated with Alzheimer's and Vascular Dementia: A Registry-Based Long-Term Follow-Up of Two Large Cohorts. 62
31984866 2020
23
The significance of serum thyroglobulin measurement before and after the treatment of toxic nodular goiter with 131I. 62
31977753 2020
24
Papillary thyroid carcinoma presenting as a functioning thyroid nodule: report of 2 rare cases. 62
33284874 2020
25
Toxic nodular goiter and thyroid cancer: Is hyperthyroidism protective against thyroid cancer? 62
31104806 2019
26
Association of Radioactive Iodine Treatment With Cancer Mortality in Patients With Hyperthyroidism. 62
31260066 2019
27
Thyrotoxicosis with concomitant thyroid cancer. 62
31026810 2019
28
Serum autotaxin levels are associated with Graves' disease. 62
30814442 2019
29
A Comparison of Doppler Flow Parameters in the Ophthalmic Artery and Central Retinal Artery in Patients With Graves' Disease and Toxic Nodular Goiter. 62
31681176 2019
30
Early Experience with LigaSure Thyroidectomy in a Nigeria Teaching Hospital. 62
31007515 2019
31
A Case of Marine-Lenhart Syndrome with Predominance of Plummer Disease. 62
31292360 2019
32
Intractable hiccups as the presenting symptom of toxic nodular goiter. 62
31595247 2018
33
Stimulatory TSH-Receptor Antibodies and Oxidative Stress in Graves Disease. 62
30099546 2018
34
Patients with Benign Thyroid Diseases Experience an Impaired Sex Life. 62
30039748 2018
35
Therapeutic plasmapheresis in thyrotoxic patients. 62
29968224 2018
36
Outcome of radioactive iodine therapy in Toxic Nodular Goiter in Pakistan. 62
30344566 2018
37
Determinants of Visfatin/NAMPT Serum Concentration and its Leukocyte Expression in Hyperthyroidism. 62
30184561 2018
38
UNKNOWN AND ALREADY KNOWN THYROID ABNORMALITIES IN PRIMARY HYPERPARATHYROIDISM. 62
30048169 2018
39
COMPARISON OF CARDIAC ARRHYTHMIA TYPES BETWEEN HYPERTHYROID PATIENTS WITH GRAVES' DISEASE AND TOXIC NODULAR GOITER. 62
31149279 2018
40
THE TRENDS OF HYPERTHYROIDISM TREATMENT IN TAIWAN: A NATIONWIDE POPULATION-BASED STUDY. 62
29688762 2018
41
The Pathology of Hyperthyroidism. 62
30559722 2018
42
Incidental thyroid carcinoma in surgery-treated hyperthyroid patients with Graves' disease: a systematic review and meta-analysis of cohort studies. 62
29872340 2018
43
Hyperthyroid patients without Graves' orbitopathy are not at increased risk of developing glaucoma: a nationwide Danish register-based case-control study. 62
29198022 2018
44
Familial aggregation and heritability of type 1 diabetes mellitus and coaggregation of chronic diseases in affected families. 62
30349392 2018
45
Red cell distribution width - a new marker for exacerbation of heart failure in patients with hypothyroidism following radioiodine therapy. 62
29504626 2018
46
Thyroid malignancy risk in different clinical thyroid diseases 62
29151324 2017
47
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. 62
28471268 2017
48
Is there a group of patients at greater risk for hematoma following thyroidectomy? A systematic review and meta-analysis. 62
27481173 2017
49
Subclinical Hyperthyroidism: When to Consider Treatment. 62
28671443 2017
50
The Concomitant Association of Thyroid Disorders and Myasthenia Gravis. 62
28729915 2017

Variations for Plummer's Disease

Expression for Plummer's Disease

Search GEO for disease gene expression data for Plummer's Disease.

Pathways for Plummer's Disease

Pathways related to Plummer's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.34 TSHR PTH CALCA
2 10.91 SELL SELE
3 10.79 SELE ICAM1
4 10.5 PTH CALCA
5 10.1 TSHR TPO TG

GO Terms for Plummer's Disease

Biological processes related to Plummer's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.85 TSHR PTH CALCA
2 leukocyte tethering or rolling GO:0050901 9.62 SELL SELE
3 thyroid hormone generation GO:0006590 9.56 TPO TG
4 hormone biosynthetic process GO:0042446 9.46 TPO TG
5 leukocyte migration GO:0050900 9.26 SELL SELE ICAM1
6 leukocyte cell-cell adhesion GO:0007159 9.17 SELL SELE ICAM1 CALCA

Molecular functions related to Plummer's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 TG PTH CALCA
2 oligosaccharide binding GO:0070492 8.92 SELL SELE

Sources for Plummer's Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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