MCID: PLM011
MIFTS: 34

Plummer's Disease

Categories: Endocrine diseases

Aliases & Classifications for Plummer's Disease

MalaCards integrated aliases for Plummer's Disease:

Name: Plummer's Disease 12 15
Toxic Nodular Goiter 12 17 70
Goiter Toxic Nodular 54
Plummer Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11277
ICD9CM 34 242.3
NCIt 50 C35171
SNOMED-CT 67 57777000
ICD10 32 E05.2
UMLS 70 C0342127

Summaries for Plummer's Disease

MalaCards based summary : Plummer's Disease, also known as toxic nodular goiter, is related to goiter and nodular goiter. An important gene associated with Plummer's Disease is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Allograft rejection. The drugs Methimazole and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related phenotypes are endocrine/exocrine gland and immune system

Related Diseases for Plummer's Disease

Diseases related to Plummer's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 goiter 30.5 TSHR TPO TG SERPINA7
2 nodular goiter 30.2 TSHR TPO TG ICAM1
3 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.1 TSHR TPO TG
4 adenoma 30.1 TSHR TG PTH
5 thyroid carcinoma 30.1 TSHR TPO TG
6 follicular adenoma 30.0 TSHR TPO TG
7 papillary carcinoma 30.0 TSHR TPO TG
8 thyroiditis 29.9 TSHR TPO TG SERPINA7
9 thyroid crisis 29.9 TSHR TPO TG SERPINA7
10 toxic diffuse goiter 29.8 TSHR TPO TG SERPINA7
11 hashimoto thyroiditis 29.8 TSHR TPO TG SERPINA7 ICAM1
12 multinodular goiter 29.6 TSHR TPO TG PTH
13 hypothyroidism 29.6 TSHR TPO TG SHBG SERPINA7
14 suppurative thyroiditis 29.5 TSHR TPO TG PTH
15 hyperthyroidism 29.5 TSHR TPO TG SHBG SERPINA7 PTH
16 graves disease 1 29.1 TSHR TPO TG SHBG SERPINA7 PTH
17 endemic goiter 29.1 TSHR TPO TG SERPINA7 PTH
18 nontoxic goiter 29.0 TSHR TPO TG SHBG SERPINA7 PTH
19 graves' disease 28.9 TSHR TPO TG SERPINA7 SELL SELE
20 thyroid gland disease 28.8 TSHR TPO TG SHBG SERPINA7 PTH
21 mechanical strabismus 10.3 TPO TG
22 nonencapsulated sclerosing carcinoma 10.3 TPO TG
23 aspirin allergy 10.3 TPO TG
24 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.3 TPO TG
25 heterophyiasis 10.3 SELE ICAM1
26 actinic prurigo 10.3 SELE ICAM1
27 type 1 diabetes mellitus 20 10.2 TPO TG
28 rheumatoid vasculitis 10.2 SELE ICAM1
29 transient congenital hypothyroidism 10.2 TSHR TPO
30 shwartzman phenomenon 10.2 SELE ICAM1
31 athyreosis 10.2 TSHR TG
32 hypotropia 10.2 TSHR TPO
33 adrenal cortical hypofunction 10.2 TPO TG
34 papillary thyroid microcarcinoma 10.2 TSHR TG
35 struma ovarii 10.2 TSHR TG
36 arthus reaction 10.2 SELL ICAM1
37 benign struma ovarii 10.2 TSHR TG
38 orbital disease 10.2 TSHR TG
39 boutonneuse fever 10.2 SELL SELE
40 endophthalmitis 10.2 SELE ICAM1
41 pernicious anemia 10.2 TPO TG
42 sympathetic ophthalmia 10.2 SELE ICAM1
43 hypothyroidism, congenital, nongoitrous, 2 10.2 TSHR TG
44 hydrocele 10.2 SELE ICAM1
45 euthyroid sick syndrome 10.1 TG SERPINA7
46 iodine hypothyroidism 10.1 TSHR TPO TG
47 toxicodendron dermatitis 10.1 SELL SELE ICAM1
48 exophthalmos 10.1 TSHR TPO TG
49 leukostasis 10.1 SELL SELE ICAM1
50 erythema nodosum 10.1 SELL SELE ICAM1

Graphical network of the top 20 diseases related to Plummer's Disease:



Diseases related to Plummer's Disease

Symptoms & Phenotypes for Plummer's Disease

MGI Mouse Phenotypes related to Plummer's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.5 ICAM1 KCNE3 PTH SELL TG TPO
2 immune system MP:0005387 9.23 ICAM1 KCNE3 PTH SELE SELL TG

Drugs & Therapeutics for Plummer's Disease

Drugs for Plummer's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methimazole Approved Phase 4 60-56-0 1349907
2 Hormone Antagonists Phase 4
3 Hormones Phase 4
4 Antithyroid Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Influence of Continuous Treatment With Antithyroid Drugs on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150137 Phase 4 Methimazole
2 The Influence of Continuous Block-replacement Therapy on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
3 The Effect of 0.1 mg Recombinant Human Thyrotropin (rhTSH) on Thyroid Radioiodine-uptake and the Degree of Goiter Reduction Following 131I-therapy, in Patients With Benign Non-toxic Nodular Goiter. A Randomized, Double-blind, Placebo-controlled Trial. Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH

Search NIH Clinical Center for Plummer's Disease

Genetic Tests for Plummer's Disease

Anatomical Context for Plummer's Disease

MalaCards organs/tissues related to Plummer's Disease:

40
Thyroid, Heart, Pituitary, Eye, Bone, Breast, T Cells

Publications for Plummer's Disease

Articles related to Plummer's Disease:

(show top 50) (show all 374)
# Title Authors PMID Year
1
Soluble intercellular adhesion molecule-1 concentrations in patients with subacute thyroiditis and in patients with Graves' disease with or without ophthalmopathy. 54 61
8980891 1996
2
Circulating selectins, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in hyperthyroidism. 61 54
7541802 1995
3
Bispecific thyroglobulin and thyroperoxidase autoantibodies in patients with various thyroid and autoimmune diseases. 61 54
7962336 1994
4
The measurement of the serum sex-hormone binding globulin in various thyroid diseases. 54 61
2280997 1990
5
The Role of Nuclear Medicine in the Clinical Management of Benign Thyroid Disorders. Part 2. Nodular Goiter, Hypothyroidism, and Subacute Thyroiditis. 61
33579801 2021
6
Impact of Radioiodine Treatment on Doppler Flow Parameters in the Central Retinal Artery and Ophthalmic Artery in Patients With Hyperthyroidism. 61
32697397 2021
7
[Radioiodine therapy outcome in toxic multinodular goiter patient with concomitant hereditary Hasharon hemoglobinopathy]. 61
33351336 2020
8
Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors. 61
32838791 2020
9
Added value of circulating miRNA expression profiling to sonographic TI-RADS classification in the diagnosis of thyroid nodules. 61
32765676 2020
10
Association of Radioactive Iodine, Antithyroid Drug, and Surgical Treatments With Solid Cancer Mortality in Patients With Hyperthyroidism. 61
32701159 2020
11
Bidirectional association between alopecia areata and thyroid diseases: a nationwide population-based cohort study. 61
32705333 2020
12
A Rare Case of Subacute Painful Thyroiditis Causing Thyroid Storm and a Successful Trial of Propylthiouracil. 61
32760639 2020
13
Effective Preoperative Plasmapheresis Treatment of Severe Hyperthyroidism in a Patient with Giant Toxic Nodular Goiter and Methimazole-Induced Agranulocytosis. 61
32545570 2020
14
Graves' Disease and Toxic Nodular Goiter, Aggravated by Duration of Hyperthyroidism, Are Associated with Alzheimer's and Vascular Dementia: A Registry-Based Long-Term Follow-Up of Two Large Cohorts. 61
31984866 2020
15
The significance of serum thyroglobulin measurement before and after the treatment of toxic nodular goiter with 131I. 61
31977753 2020
16
Papillary thyroid carcinoma presenting as a functioning thyroid nodule: report of 2 rare cases. 61
33284874 2020
17
Toxic nodular goiter and thyroid cancer: Is hyperthyroidism protective against thyroid cancer? 61
31104806 2019
18
Thyrotoxicosis with concomitant thyroid cancer. 61
31026810 2019
19
Association of Radioactive Iodine Treatment With Cancer Mortality in Patients With Hyperthyroidism. 61
31260066 2019
20
Serum autotaxin levels are associated with Graves' disease. 61
30814442 2019
21
A Comparison of Doppler Flow Parameters in the Ophthalmic Artery and Central Retinal Artery in Patients With Graves' Disease and Toxic Nodular Goiter. 61
31681176 2019
22
Early Experience with LigaSure Thyroidectomy in a Nigeria Teaching Hospital. 61
31007515 2019
23
Intractable hiccups as the presenting symptom of toxic nodular goiter. 61
31595247 2018
24
Therapeutic plasmapheresis in thyrotoxic patients. 61
29968224 2018
25
Stimulatory TSH-Receptor Antibodies and Oxidative Stress in Graves Disease. 61
30099546 2018
26
Patients with Benign Thyroid Diseases Experience an Impaired Sex Life. 61
30039748 2018
27
Outcome of radioactive iodine therapy in Toxic Nodular Goiter in Pakistan. 61
30344566 2018
28
Determinants of Visfatin/NAMPT Serum Concentration and its Leukocyte Expression in Hyperthyroidism. 61
30184561 2018
29
UNKNOWN AND ALREADY KNOWN THYROID ABNORMALITIES IN PRIMARY HYPERPARATHYROIDISM. 61
30048169 2018
30
COMPARISON OF CARDIAC ARRHYTHMIA TYPES BETWEEN HYPERTHYROID PATIENTS WITH GRAVES' DISEASE AND TOXIC NODULAR GOITER. 61
31149279 2018
31
THE TRENDS OF HYPERTHYROIDISM TREATMENT IN TAIWAN: A NATIONWIDE POPULATION-BASED STUDY. 61
29688762 2018
32
The Pathology of Hyperthyroidism. 61
30559722 2018
33
Incidental thyroid carcinoma in surgery-treated hyperthyroid patients with Graves' disease: a systematic review and meta-analysis of cohort studies. 61
29872340 2018
34
Red cell distribution width - a new marker for exacerbation of heart failure in patients with hypothyroidism following radioiodine therapy. 61
29504626 2018
35
Familial aggregation and heritability of type 1 diabetes mellitus and coaggregation of chronic diseases in affected families. 61
30349392 2018
36
Hyperthyroid patients without Graves' orbitopathy are not at increased risk of developing glaucoma: a nationwide Danish register-based case-control study. 61
29198022 2018
37
Thyroid malignancy risk in different clinical thyroid diseases 61
29151324 2017
38
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. 61
28471268 2017
39
Is there a group of patients at greater risk for hematoma following thyroidectomy? A systematic review and meta-analysis. 61
27481173 2017
40
Subclinical Hyperthyroidism: When to Consider Treatment. 61
28671443 2017
41
The Concomitant Association of Thyroid Disorders and Myasthenia Gravis. 61
28729915 2017
42
Robot-assisted laparoscopic (RAL) procedures in general surgery. 61
26443708 2016
43
Quality-of-Life Impairments Persist Six Months After Treatment of Graves' Hyperthyroidism and Toxic Nodular Goiter: A Prospective Cohort Study. 61
27370744 2016
44
[Rarer causes of thyrotoxicosis]. 61
27526430 2016
45
Organ Dose Estimates for Hyperthyroid Patients Treated with (131)I: An Update of the Thyrotoxicosis Follow-Up Study. 61
26579944 2015
46
TREATMENT OF SUBCLINICAL HYPERTHYROIDISM: EFFECT ON BODY COMPOSITION. 61
26545695 2015
47
A critical review of food-associated factors proposed in the etiology of feline hyperthyroidism. 61
25366172 2015
48
Long-Term Results of Fixed High-Dose I-131 Treatment for Toxic Nodular Goiter: Higher Euthyroidism Rates in Geriatric Patients. 61
27529883 2015
49
Effectiveness of Radioiodine Treatment for Toxic Nodular Goiter. 61
27529884 2015
50
Graves Disease Induced by Radioiodine Therapy for Toxic Nodular Goiter: A Case Report. 61
27529890 2015

Variations for Plummer's Disease

Expression for Plummer's Disease

Search GEO for disease gene expression data for Plummer's Disease.

Pathways for Plummer's Disease

GO Terms for Plummer's Disease

Cellular components related to Plummer's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.13 SELE KCNE3 ICAM1
2 extracellular space GO:0005615 9.1 TPO TG SERPINA7 SELE PTH ICAM1

Biological processes related to Plummer's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.54 SELL SELE ICAM1
2 activation of phospholipase C activity GO:0007202 9.4 SELE PTH
3 leukocyte cell-cell adhesion GO:0007159 9.32 SELE ICAM1
4 leukocyte tethering or rolling GO:0050901 9.26 SELL SELE
5 thyroid hormone generation GO:0006590 9.16 TPO TG
6 negative regulation of calcium ion transport GO:0051926 8.96 PTH ICAM1
7 hormone biosynthetic process GO:0042446 8.62 TPO TG

Molecular functions related to Plummer's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oligosaccharide binding GO:0070492 8.62 SELL SELE

Sources for Plummer's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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