MCID: PLM011
MIFTS: 37

Plummer's Disease

Categories: Endocrine diseases

Aliases & Classifications for Plummer's Disease

MalaCards integrated aliases for Plummer's Disease:

Name: Plummer's Disease 12 15
Toxic Nodular Goiter 12 73
Goiter Toxic Nodular 55
Plummer Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11277
ICD10 33 E05.2
ICD9CM 35 242.3
NCIt 50 C35171
UMLS 73 C0342127

Summaries for Plummer's Disease

MalaCards based summary : Plummer's Disease, also known as toxic nodular goiter, is related to nodular goiter and goiter. An important gene associated with Plummer's Disease is TG (Thyroglobulin), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Cell adhesion molecules (CAMs). The drugs Antithyroid Agents and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid and bone, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Plummer's Disease

Diseases related to Plummer's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 nodular goiter 32.5 ICAM1 TG TPO
2 goiter 31.0 TG THRB TPO
3 toxic diffuse goiter 30.5 TG TPO
4 thyroiditis 30.4 TG THRB TPO
5 multinodular goiter 30.3 TG TPO
6 graves' disease 29.8 ICAM1 TG THRB TPO
7 thyroid cancer 29.3 TG THRB TPO
8 nontoxic goiter 29.2 SHBG TG TPO
9 hyperthyroidism 28.8 SHBG TG THRB TPO
10 hypothyroidism 28.5 SHBG TG THRB TPO
11 familial thyroid dyshormonogenesis 10.6 TG TPO
12 subacute lymphocytic thyroiditis 10.6 TG TPO
13 neonatal hypothyroidism 10.5 TG TPO
14 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.5 TG TPO
15 endemic goiter 10.5 TG TPO
16 premature menopause 10.5 TG TPO
17 hypothyroidism, congenital, nongoitrous, 4 10.5 TG TPO
18 myxedema 10.5 TG TPO
19 pernicious anemia 10.5 TG TPO
20 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.5 TG TPO
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4 TG TPO
22 anaplastic thyroid cancer 10.4 TG TPO
23 follicular adenoma 10.4 TG TPO
24 pendred syndrome 10.3 TG TPO
25 toxicodendron dermatitis 10.3 ICAM1 SELL
26 hypersensitivity reaction disease 10.2 TG TPO
27 arthus reaction 10.2 ICAM1 SELL
28 chronic venous insufficiency 10.2 ICAM1 SELL
29 heterophyiasis 10.2 ICAM1 SELE
30 congenital hypothyroidism 10.2 TG TPO
31 lymphocytic vasculitis 10.2 ICAM1 SELE
32 mooren's ulcer 10.2 ICAM1 SELE
33 venous insufficiency 10.2 ICAM1 SELL
34 pleurisy 10.2 ICAM1 SELL
35 hymenolepiasis 10.2 ICAM1 SELE
36 subendocardial myocardial infarction 10.2 ICAM1 SELE
37 actinic prurigo 10.2 ICAM1 SELE
38 papillary carcinoma 10.1 TG TPO
39 endophthalmitis 10.1 ICAM1 SELE
40 rheumatoid vasculitis 10.1 ICAM1 SELE
41 hypersensitivity reaction type iii disease 10.1 ICAM1 SELE
42 boutonneuse fever 10.1 SELE SELL
43 cytomegalovirus infection 10.1 ICAM1 SELE
44 differentiated thyroid carcinoma 10.1 TG TPO
45 retinitis pigmentosa 60 10.1 SELE SELL
46 plasmodium vivax malaria 10.1 ICAM1 SELE
47 cutaneous lupus erythematosus 10.0 ICAM1 SELE
48 hypoadrenalism 10.0 SHBG TG
49 autoimmune disease of endocrine system 10.0 ICAM1 TG TPO
50 leukocyte adhesion deficiency, type i 10.0 SELE SELL

Graphical network of the top 20 diseases related to Plummer's Disease:



Diseases related to Plummer's Disease

Symptoms & Phenotypes for Plummer's Disease

MGI Mouse Phenotypes related to Plummer's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 TG THRB TPO ICAM1 SELL
2 growth/size/body region MP:0005378 9.63 TG THRB TPO ICAM1 SELE SELL
3 hematopoietic system MP:0005397 9.43 TG THRB TPO ICAM1 SELE SELL
4 homeostasis/metabolism MP:0005376 9.1 TG THRB TPO ICAM1 SELE SELL

Drugs & Therapeutics for Plummer's Disease

Drugs for Plummer's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antithyroid Agents Phase 4
2 Hormone Antagonists Phase 4
3 Hormones Phase 4
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
5
Salmon Calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
6
Calcitonin gene-related peptide Investigational Phase 2 83652-28-2
7 Bone Density Conservation Agents Phase 2
8 calcitonin Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
2 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
3 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
4 Thumb-ECG Ambulant Screening for Atrial Fibrillation in Patients Treated for Hyperthyroidism (TAMBOURINE) Recruiting NCT01945229
5 Bone Structure and Strength Evaluated by Extreme-CT Scan Before and After Treatment of Hyper- and Hypothyroidism Recruiting NCT02005250

Search NIH Clinical Center for Plummer's Disease

Genetic Tests for Plummer's Disease

Anatomical Context for Plummer's Disease

MalaCards organs/tissues related to Plummer's Disease:

41
Thyroid, Bone

Publications for Plummer's Disease

Articles related to Plummer's Disease:

(show top 50) (show all 81)
# Title Authors Year
1
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. ( 28471268 )
2017
2
Quality-of-Life Impairments Persist Six Months After Treatment of Graves' Hyperthyroidism and Toxic Nodular Goiter: A Prospective Cohort Study. ( 27370744 )
2016
3
Long-Term Results of Fixed High-Dose I-131 Treatment for Toxic Nodular Goiter: Higher Euthyroidism Rates in Geriatric Patients. ( 27529883 )
2015
4
Effectiveness of Radioiodine Treatment for Toxic Nodular Goiter. ( 27529884 )
2015
5
Graves Disease Induced by Radioiodine Therapy for Toxic Nodular Goiter: A Case Report. ( 27529890 )
2015
6
Thyroid cancer in patients with toxic nodular goiter-is the incidence increasing? ( 25896315 )
2015
7
Laser ablation and 131-iodine: a 24-month pilot study of combined treatment for large toxic nodular goiter. ( 24684455 )
2014
8
ANIMAL MODELS OF DISEASE: Feline hyperthyroidism: an animal model for toxic nodular goiter. ( 25297557 )
2014
9
Efficacy of different protocols of radioiodine therapy for treatment of toxic nodular goiter: systematic review and meta-analysis of the literature. ( 24803943 )
2014
10
Bone mineral density in geriatric patients with toxic nodular goiter. ( 25161096 )
2014
11
Thyroid function: cause of increased mortality differs for Graves disease and toxic nodular goiter. ( 23318229 )
2013
12
Graves' disease and toxic nodular goiter are both associated with increased mortality but differ with respect to the cause of death: a Danish population-based register study. ( 23253072 )
2013
13
Toxic nodular goiter and cancer: a compelling case for thyroidectomy. ( 23108556 )
2013
14
Thyroid cancer in Plummer's disease. ( 23456166 )
2013
15
Efficiency of radioactive I-131 therapy in geriatric patients with toxic nodular goiter. ( 23211880 )
2012
16
Efficacy of low and high fixed dose radioactive iodine therapy in patients with toxic nodular goiter. ( 21519320 )
2011
17
Progressive macular hypomelanosis arising in a young African American woman in association with pregnancy and a toxic nodular goiter. ( 20514800 )
2010
18
Toxic nodular goiter with thyroid papillary microcarcinoma. ( 20575904 )
2010
19
Intra-thyroid blood flow in Plummer's disease. ( 18520123 )
2008
20
Evidence-based management of toxic multinodular goiter (Plummer's Disease). ( 18357484 )
2008
21
Comments regarding "Subclinical hyperthyroidism in cats: a spontaneous model of subclinical toxic nodular goiter in humans?". ( 19067644 )
2008
22
The occurrence of hypothyroidism following radioactive iodine treatment of toxic nodular goiter is related to the TSH level. ( 17632747 )
2007
23
Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves' disease or toxic nodular goiter. ( 17244787 )
2007
24
Subclinical hyperthyroidism in cats: a spontaneous model of subclinical toxic nodular goiter in humans? ( 18177255 )
2007
25
[Soluble forms of adhesion molecules sELAM-1 and sICAM-1 in Graves disease and toxic nodular goiter]. ( 14768174 )
2003
26
Cytologic appearance of toxic nodular goiter after thyrostatic treatment. A karyometric study. ( 12630081 )
2003
27
A rare coexistence of primary hyperparathyroidism and hyperthyroidism due to toxic nodular goiter--a case report. ( 12879780 )
2003
28
Ventricular dysfunction in a patient with Plummer's disease: a case report. ( 12027234 )
2002
29
Smoking as a risk factor for Graves' disease, toxic nodular goiter, and autoimmune hypothyroidism. ( 11838733 )
2002
30
Generalized granuloma annulare associated with Plummer's disease. ( 12224712 )
2002
31
Current treatment of nodular goiter with hyperthyroidism (Plummer's disease): surgery versus radioiodine. ( 12490836 )
2002
32
Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter. ( 11453524 )
2001
33
False-positive suspicion of a thyroid metastatic lesion by In-111 pentetreotide uptake in a toxic nodular goiter. ( 11353323 )
2001
34
Radioiodine therapy for Plummer's disease based on the thyroid uptake of technetium-99m pertechnetate. ( 11007508 )
2000
35
Plummer's disease with spontaneous progression to hypothyroidism. ( 10656280 )
1999
36
Radioiodine treatment of Plummer's disease. ( 9867200 )
1998
37
Diagnostic items and treatment of Plummer's disease: a study on 180 patients. ( 9842101 )
1998
38
Cost analysis of surgical procedures for toxic nodular goiter. ( 9867202 )
1998
39
Sequential occurrence of toxic nodular goiter followed by Graves' disease. ( 15251744 )
1998
40
Toxic nodular goiter. Toxic adenoma and toxic multinodular goiter. ( 9534034 )
1998
41
Differentiated operative therapy of thyroid autonomy (Plummer's disease). ( 9867204 )
1998
42
Toxic nodular goiter and thymic hyperplasia in an adult. Case report. ( 9557476 )
1997
43
Serum levels of the carboxy-terminal cross-linked telopeptide of type I collagen and laminin are elevated in Graves' disease but not in toxic nodular goiter. ( 7768039 )
1995
44
Delayed radioiodine organification in Plummer's disease. ( 7750210 )
1995
45
Depression and anxiety in an 85-year-old woman with a toxic nodular goiter. ( 7789785 )
1995
46
Etiopathology of feline toxic nodular goiter. ( 8053112 )
1994
47
Concurrent Plummer's disease and parathyroid adenoma. Diagnostic and therapeutic approaches to a difficult clinical problem. ( 8062469 )
1994
48
Serum selenium concentrations in patients with autoimmune thyroiditis and non-toxic nodular goiter. ( 7508739 )
1993
49
Symptomatology of Graves' disease and Plummer's disease in relation to age and thyroid hormone level. ( 8377872 )
1993
50
Unusual thyroid scintigrams in Plummer's disease during methimazole therapy. ( 2044327 )
1991

Variations for Plummer's Disease

Expression for Plummer's Disease

Search GEO for disease gene expression data for Plummer's Disease.

Pathways for Plummer's Disease

GO Terms for Plummer's Disease

Biological processes related to Plummer's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.37 ICAM1 SELE
2 leukocyte migration GO:0050900 9.33 ICAM1 SELE SELL
3 leukocyte cell-cell adhesion GO:0007159 9.32 ICAM1 SELE
4 thyroid gland development GO:0030878 9.26 TG THRB
5 leukocyte tethering or rolling GO:0050901 8.96 SELE SELL
6 hormone biosynthetic process GO:0042446 8.62 TG TPO

Molecular functions related to Plummer's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oligosaccharide binding GO:0070492 8.62 SELE SELL

Sources for Plummer's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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