MCID: PNM013
MIFTS: 43

Pneumococcal Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pneumococcal Meningitis

MalaCards integrated aliases for Pneumococcal Meningitis:

Name: Pneumococcal Meningitis 58 17 32
Meningitis, Pneumococcal 70

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare infectious diseases


External Ids:

ICD10 32 G00.1
MESH via Orphanet 45 D008586
ICD10 via Orphanet 33 G00.1
UMLS via Orphanet 71 C0025295
Orphanet 58 ORPHA55655
UMLS 70 C0025295

Summaries for Pneumococcal Meningitis

MalaCards based summary : Pneumococcal Meningitis, also known as meningitis, pneumococcal, is related to bacterial meningitis and meningitis. An important gene associated with Pneumococcal Meningitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Innate Immune System and TNFR1 Pathway. The drugs Phenytoin and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, brain and cortex, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Pneumococcal Meningitis

Diseases related to Pneumococcal Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)
# Related Disease Score Top Affiliating Genes
1 bacterial meningitis 31.5 MMP9 C3
2 meningitis 31.5 MMP9 CASP1 C3
3 streptococcus pneumonia 30.3 CASP1 C3
4 hemolytic-uremic syndrome 29.8 C5 C3
5 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
6 ocular motor apraxia 10.6
7 hydrocephalus 10.5
8 branchiootic syndrome 1 10.5
9 brain edema 10.5
10 vasculitis 10.5
11 otitis media 10.5
12 sensorineural hearing loss 10.4
13 haemophilus influenzae 10.4
14 intracranial hypertension 10.4
15 mollaret meningitis 10.4
16 endocarditis 10.3
17 bacterial infectious disease 10.3
18 toxic shock syndrome 10.3
19 labyrinthitis 10.3
20 head injury 10.3
21 meningococcal meningitis 10.3
22 meningoencephalitis 10.3
23 disease by infectious agent 10.3
24 mastoiditis 10.3
25 thrombosis 10.3
26 quadriplegia 10.3
27 sickle cell disease 10.3
28 brain injury 10.3
29 ataxia and polyneuropathy, adult-onset 10.2
30 myelitis 10.2
31 pleural empyema 10.2
32 pneumonia 10.2
33 paraplegia 10.2
34 aneurysm 10.2
35 immune deficiency disease 10.2
36 mulchandani-bhoj-conlin syndrome 10.2
37 disseminated intravascular coagulation 10.2
38 streptococcal meningitis 10.2
39 purpura 10.2
40 cytokine deficiency 10.2
41 sickle cell anemia 10.1
42 ifap syndrome 2 10.1
43 exanthem 10.1
44 osteomyelitis 10.1
45 purulent labyrinthitis 10.1
46 communicating hydrocephalus 10.1
47 status epilepticus 10.1
48 cerebritis 10.1
49 intracranial thrombosis 10.1
50 pathologic nystagmus 10.1

Comorbidity relations with Pneumococcal Meningitis via Phenotypic Disease Network (PDN):


Otitis Media Respiratory Failure

Graphical network of the top 20 diseases related to Pneumococcal Meningitis:



Diseases related to Pneumococcal Meningitis

Symptoms & Phenotypes for Pneumococcal Meningitis

MGI Mouse Phenotypes related to Pneumococcal Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.88 AKT3 C3 C5 CASP1 CASP3 MMP9
2 homeostasis/metabolism MP:0005376 9.85 AKT3 C3 C5 CASP1 CASP3 MMP9
3 immune system MP:0005387 9.8 AKT3 C3 C5 CASP1 CASP3 MMP9
4 digestive/alimentary MP:0005381 9.73 C3 CASP1 CASP3 MMP9
5 mortality/aging MP:0010768 9.73 AKT3 C3 C5 CASP1 CASP3 MMP9
6 nervous system MP:0003631 9.63 AKT3 C3 C5 CASP1 CASP3 MMP9
7 renal/urinary system MP:0005367 9.35 C3 C5 CASP1 CASP3 MMP9
8 reproductive system MP:0005389 9.02 AKT3 C3 CASP1 CASP3 MMP9

Drugs & Therapeutics for Pneumococcal Meningitis

Drugs for Pneumococcal Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
4 Anti-Bacterial Agents Phase 4
5 Antibiotics, Antitubercular Phase 4
6 Sodium Channel Blockers Phase 4
7 Anticonvulsants Phase 4
8 Diuretics, Potassium Sparing Phase 4
9 Analgesics, Non-Narcotic Phase 4
10 Analgesics Phase 4
11 Lactams Phase 4
12 Antipyretics Phase 4
13 beta-Lactams Phase 4
14
Daptomycin Approved, Investigational Phase 2 103060-53-3 16129629
15 Anti-Infective Agents Phase 2
16
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
17
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
18
Vancomycin Approved 1404-90-6 14969 441141
19 Heptavalent Pneumococcal Conjugate Vaccine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. A Multi-center Comparative Randomized Double-blind and Placebo-controlled Clinical Trial Unknown status NCT01478035 Phase 4 Phenytoin;placebo
2 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis, Especially of Pneumococcal Meningitis, in Angola. Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
3 Adjunction of Daptomycin for the Treatment of Pneumococcal Meningitis: AddaMAP Study Recruiting NCT03480191 Phase 2 Daptomycin
4 Vancomycin Concentration in Cerebrospinal Fluid During Pneumococcal Meningitis Treated With Dexamethasone Completed NCT00162578
5 Prevalence of Pneumococcal Meningitis in the Paediatric Population in Spain Four Years After the Marketing of Prevenar. Completed NCT00227214

Search NIH Clinical Center for Pneumococcal Meningitis

Genetic Tests for Pneumococcal Meningitis

Anatomical Context for Pneumococcal Meningitis

MalaCards organs/tissues related to Pneumococcal Meningitis:

40
Neutrophil, Brain, Cortex, Spinal Cord, Spleen, Myeloid, Endothelial

Publications for Pneumococcal Meningitis

Articles related to Pneumococcal Meningitis:

(show top 50) (show all 1940)
# Title Authors PMID Year
1
Drastic reduction in pneumococcal meningitis in children owing to the introduction of pneumococcal conjugate vaccines: Longitudinal analysis from 2002 to 2016 in Japan. 61
33303361 2021
2
Cerebroprotective Effects of 2-Ethyl-6-methyl-3-hydroxypyridine-2,6-dichlorophenyl(amino)phenylethanoic Acid in the Treatment of Purulent Meningitis. 61
33799578 2021
3
Bilateral intracranial stenting for refractory post-infectious cerebral vasculitis secondary to Pneumococcal Meningitis. 61
32560919 2021
4
In vitro antimicrobial activity of daptomycin alone and in adjunction to either amoxicillin, cefotaxime or rifampin against the main pathogens responsible for bacterial meningitis in adults. 61
33774218 2021
5
Neuronal death in pneumococcal meningitis is triggered by pneumolysin and RrgA interactions with β-actin. 61
33760879 2021
6
Meningococcal and pneumococcal meningitis in the ICU: an epidemiological report from the Italian GiViTI registry. 61
33054018 2021
7
Effect of pneumococcal conjugate vaccines on mortality from lower respiratory infections and pneumonia among under-fives. 61
32730135 2021
8
Vertebral osteomyelitis as a hidden cause of persistent meningeal irritation in a patient with pneumococcal meningitis: A case report. 61
33578609 2021
9
Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host. 61
33531028 2021
10
[Steroids in infection medicine]. 61
33513649 2021
11
Brains, bacteria and behaviors: the role of interferon-gamma in the pathogenesis of pneumococcal meningitis. 61
32788465 2021
12
The provision of additional services in primary care: a cross-sectional study of incentivised additional services, social deprivation, and ethnic group. 61
33199308 2021
13
Delayed cerebral thrombosis complicating bacterial meningitis. 61
33455561 2021
14
Cerebral venous thrombosis in pneumococcal meningitis: An autopsy study. 61
33433314 2021
15
Pneumococcal Serotype-specific Opsonophagocytic Activity in Interleukin-1 Receptor-associated Kinase 4-deficient Patients. 61
33470775 2021
16
Serum cytokine profile of pediatric patients with laboratory confirmed pneumococcal meningitis. 61
33743374 2021
17
Individual responsiveness of macrophage migration inhibitory factor predicts long-term cognitive impairment after bacterial meningitis. 61
33407905 2021
18
The antimicrobial susceptibility in adult invasive pneumococcal disease in the era of pneumococcus vaccination: A hospital-based observational study in Taiwan. 61
32063458 2020
19
Role of astroglial Connexin 43 in pneumolysin cytotoxicity and during pneumococcal meningitis. 61
33370401 2020
20
Recognition and Outcomes of Pneumococcal Meningitis in 2 Tertiary Pediatric Hospitals Since the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine. 61
33181795 2020
21
Long-term neurologic and cognitive outcome and quality of life in adults after pneumococcal meningitis. 61
32006689 2020
22
The formyl peptide receptor agonist Ac2-26 alleviates neuroinflammation in a mouse model of pneumococcal meningitis. 61
33121515 2020
23
Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis. 61
33028339 2020
24
Receptor for Advanced Glycation End Products (RAGE) Mediates Cognitive Impairment Triggered by Pneumococcal Meningitis. 61
32886341 2020
25
A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis. 61
32770475 2020
26
Delayed Cerebral Vasculopathy in Pneumococcal Meningitis: Epidemiology and Clinical Outcome. A Cohort Study. 61
32531430 2020
27
Pneumococcal Meningitis Complicated by Subarachnoid Hemorrhage and Tonsillar Herniation. 61
32983693 2020
28
HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis. 61
32529267 2020
29
[A case of pneumococcal meningitis with reversible arterial stenosis]. 61
32536669 2020
30
Evaluation of pneumococcal meningitis clusters in Burkina Faso and implications for potential reactive vaccination. 61
32591290 2020
31
Safety and immunogenicity of a parenteral trivalent P2-VP8 subunit rotavirus vaccine: a multisite, randomised, double-blind, placebo-controlled trial. 61
32251641 2020
32
Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy. 61
32660552 2020
33
Pediatric bacterial meningitis and meningococcal disease profile in a Brazilian General Hospital. 61
32598866 2020
34
Pneumococcal Meningitis and Its Sequelae - A Devastating CNS Disease. 61
33074177 2020
35
Oval window perilymph fistula in child with recurrent meningitis and unilateral hearing loss. 61
32713834 2020
36
Emerging non-13-valent pneumococcal conjugate vaccine (PCV13) serotypes causing adult invasive pneumococcal disease in the late-PCV13 period in Spain. 61
31756452 2020
37
Complication of otitis media leads to opisthotonos in a toddler. 61
31987742 2020
38
NOD2 regulates microglial inflammation through the TAK1-NF-κB pathway and autophagy activation in murine pneumococcal meningitis. 61
32109527 2020
39
Characterization of pneumococcal meningitis before and after introduction of 13-valent pneumococcal conjugate vaccine in Niger, 2010-2018. 61
32327220 2020
40
New Strategy Is Needed to Prevent Pneumococcal Meningitis. 61
32032170 2020
41
Association of toll-like receptor 10 polymorphisms with pediatric pneumococcal meningitis. 61
31976578 2020
42
Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation. 61
32238192 2020
43
Lower respiratory infections mortality among Brazilians under-five before and after national pneumococcal conjugate vaccine implementation. 61
32033849 2020
44
Molecular Detection and Serotyping of Streptococcus pneumoniae in Children with Suspected Meningitis in Northeast Iran. 61
32210489 2020
45
Hereditary Deficiency of the Second Component of Complement: Early Diagnosis and 21-Year Follow-Up of a Family. 61
32164349 2020
46
Recurrent Pneumococcal Meningitis Secondary to Nasoethmoidal Meningocele. 61
31876613 2020
47
Resurgence of pneumococcal meningitis in Europe and Northern America. 61
31100424 2020
48
Case Commentary: Delayed Cerebral Vasculitis Associated with the Development of Ceftriaxone-Resistant Pneumococcal Meningitis. 61
31907185 2020
49
Emergence of Ceftriaxone Resistance during a Case of Pneumococcal Meningitis with Fatal Evolution. 61
31712218 2020
50
Rapidly fatal pneumococcal meningitis following non-penetrating traumatic brain injury. 61
32071126 2020

Variations for Pneumococcal Meningitis

Expression for Pneumococcal Meningitis

Search GEO for disease gene expression data for Pneumococcal Meningitis.

Pathways for Pneumococcal Meningitis

Pathways related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 MMP9 CASP3 CASP1 C5 C3 AKT3
2
Show member pathways
12.74 MMP9 CASP3 CASP1 AKT3
3
Show member pathways
12.58 MMP9 CASP3 AKT3
4 12.55 MMP9 CASP3 AKT3
5
Show member pathways
12.55 CASP3 C5 C3
6
Show member pathways
12.55 MMP9 CASP3 CASP1 C3 AKT3
7
Show member pathways
12.52 CASP3 CASP1 AKT3
8 12.46 CASP3 CASP1 AKT3
9
Show member pathways
12.43 CASP3 CASP1 AKT3
10
Show member pathways
12.39 CASP3 CASP1 AKT3
11 12.32 CASP3 C5 C3 AKT3
12
Show member pathways
12.21 CASP3 CASP1 AKT3
13 12.1 CASP1 C3 AKT3
14 11.98 MMP9 CASP3 AKT3
15
Show member pathways
11.93 CASP3 C3 AKT3
16
Show member pathways
11.9 CASP3 CASP1 AKT3
17 11.86 CASP3 C3 AKT3
18
Show member pathways
11.84 CASP3 CASP1 AKT3
19 11.62 CASP3 AKT3
20 11.62 MMP9 CASP3 C5
21
Show member pathways
11.57 CASP3 AKT3
22
Show member pathways
11.56 CASP3 AKT3
23
Show member pathways
11.55 C5 C3
24 11.49 CASP3 AKT3
25 11.48 MMP9 CASP3 AKT3
26 11.43 MMP9 CASP3
27 11.41 MMP9 CASP3
28 11.35 MMP9 CASP3
29 11.16 CASP3 CASP1
30 11.05 CASP3 CASP1
31 10.92 CASP3 CASP1
32 10.89 CASP3 CASP1 C3
33 10.81 CASP3 CASP1 C5 C3

GO Terms for Pneumococcal Meningitis

Biological processes related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.54 MMP9 CASP3 CASP1
2 protein processing GO:0016485 9.43 CASP3 CASP1
3 apoptotic signaling pathway GO:0097190 9.4 CASP3 CASP1
4 cellular response to organic substance GO:0071310 9.32 CASP3 CASP1
5 positive regulation of vascular endothelial growth factor production GO:0010575 9.26 C5 C3
6 execution phase of apoptosis GO:0097194 9.16 CASP3 CASP1
7 complement activation, alternative pathway GO:0006957 8.96 C5 C3
8 positive regulation of angiogenesis GO:0045766 8.8 C5 C3 AKT3

Molecular functions related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.5 MMP9 CASP3 CASP1
2 endopeptidase inhibitor activity GO:0004866 9.26 C5 C3
3 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.16 CASP3 CASP1
4 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 8.96 CASP3 CASP1
5 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 8.62 CASP3 CASP1

Sources for Pneumococcal Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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