MCID: PNM013
MIFTS: 40

Pneumococcal Meningitis

Categories: Neuronal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Pneumococcal Meningitis

MalaCards integrated aliases for Pneumococcal Meningitis:

Name: Pneumococcal Meningitis 59
Meningitis, Pneumococcal 73

Classifications:



External Ids:

Orphanet 59 ORPHA55655
ICD10 via Orphanet 34 G00.1
MESH via Orphanet 45 D008586
UMLS via Orphanet 74 C0025295
ICD10 33 G00.1
UMLS 73 C0025295

Summaries for Pneumococcal Meningitis

MalaCards based summary : Pneumococcal Meningitis, also known as meningitis, pneumococcal, is related to meningitis and brain edema. An important gene associated with Pneumococcal Meningitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and TNFR1 Pathway. The drugs Phenytoin and Cefoxitin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and neutrophil, and related phenotypes are cellular and hematopoietic system

Related Diseases for Pneumococcal Meningitis

Diseases related to Pneumococcal Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 meningitis 31.0 MBL2 MMP9
2 brain edema 29.8 GLUL MMP9
3 cerebritis 10.4
4 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
5 pneumonia 10.2
6 neuronitis 10.2
7 endocarditis 10.1
8 thrombosis 10.0
9 brain injury 9.9
10 vasculitis 9.9
11 aging 9.9
12 quadriplegia 9.9
13 depression 9.9
14 aneurysm 9.9
15 endotheliitis 9.9
16 common variable immunodeficiency 9.9
17 sinusitis 9.9
18 otitis media 9.9
19 sickle cell disease 9.9
20 labyrinthitis 9.9
21 sphenoid sinusitis 9.9
22 hepatitis c 9.7
23 febrile seizures 9.7
24 epidural abscess 9.7
25 encephalomalacia 9.7
26 peritonitis 9.7
27 cerebral arteritis 9.7
28 cervicitis 9.7
29 herpes simplex 9.7
30 glomerulonephritis 9.7
31 pulmonary edema 9.7
32 hemoglobinopathy 9.7
33 hepatitis 9.7
34 streptococcal meningitis 9.7
35 antiphospholipid syndrome 9.7
36 chickenpox 9.7
37 hydrocephalus 9.7
38 cauda equina syndrome 9.7
39 ischemia 9.7
40 pyomyositis 9.7
41 optic neuritis 9.7
42 thymoma 9.7
43 eczema herpeticum 9.7
44 cardiac arrest 9.7
45 aseptic meningitis 9.7
46 purpura 9.7
47 intracranial hypertension 9.7
48 thrombophilia due to thrombin defect 9.7
49 hemolytic-uremic syndrome 9.7
50 bacterial meningitis 9.7

Comorbidity relations with Pneumococcal Meningitis via Phenotypic Disease Network (PDN):


Otitis Media Respiratory Failure

Graphical network of the top 20 diseases related to Pneumococcal Meningitis:



Diseases related to Pneumococcal Meningitis

Symptoms & Phenotypes for Pneumococcal Meningitis

MGI Mouse Phenotypes related to Pneumococcal Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 GLUL MAPK10 MIF MMP9 NFKBIE
2 hematopoietic system MP:0005397 9.02 MAPK10 MBL2 MIF MMP9 NFKBIE

Drugs & Therapeutics for Pneumococcal Meningitis

Drugs for Pneumococcal Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Cefoxitin Approved Phase 4 35607-66-0 441199
3
Acetaminophen Approved Phase 4 103-90-2 1983
4
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
5 Sodium Channel Blockers Phase 4
6 Diuretics, Potassium Sparing Phase 4
7 Anti-Bacterial Agents Phase 4,Phase 2
8 Antibiotics, Antitubercular Phase 4
9 Anticonvulsants Phase 4
10 Analgesics Phase 4
11 Analgesics, Non-Narcotic Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Anti-Infective Agents Phase 4,Phase 2
14 Lactams Phase 4
15 Antipyretics Phase 4
16 beta-Lactams Phase 4
17
Ceftobiprole Approved, Investigational Phase 2 209467-52-7 6918430
18 Ceftobiprole medocaril Phase 2
19 Cephalosporins Phase 2
20
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
21
Vancomycin Approved 1404-90-6 441141 14969
22 Dexamethasone acetate 1177-87-3
23 glucocorticoids
24 Gastrointestinal Agents
25 Heptavalent Pneumococcal Conjugate Vaccine
26 Hormone Antagonists
27 Hormones
28 Vaccines
29 Hormones, Hormone Substitutes, and Hormone Antagonists
30 Antiemetics
31 Anti-Inflammatory Agents
32 BB 1101
33 Autonomic Agents
34 Antineoplastic Agents, Hormonal

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4 Phenytoin;placebo
2 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
3 Adjunction of Daptomycin for the Treatment of Pneumococcal Meningitis Recruiting NCT03480191 Phase 2 Daptomycin
4 Open and Exploratory Trial to Investigate the Pharmacokinetic of Ceftobiprole Medocaril in Patients With CSF Device Recruiting NCT03317093 Phase 2 Ceftobiprole Medocaril
5 Vancomycin Concentration in Cerebrospinal Fluid During Pneumococcal Meningitis Completed NCT00162578
6 Study Evaluating Pneumococcal Meningitis in the Paediatric Population in Spain Four Years After the Marketing of Prevenar. Completed NCT00227214
7 Child Pneumococcal Serotype Epidemiology In Greece Completed NCT01111214
8 Surveillance of Hospitalised Pneumonia and Bacterial Meningitis in Tône District, Togo, 2010-2013 Recruiting NCT01747369
9 Costa Rica Epidemiological Study on S. Pneumoniae Suspended NCT01308827

Search NIH Clinical Center for Pneumococcal Meningitis

Genetic Tests for Pneumococcal Meningitis

Anatomical Context for Pneumococcal Meningitis

MalaCards organs/tissues related to Pneumococcal Meningitis:

41
Brain, Testes, Neutrophil, Bone, Cortex, Endothelial, Spinal Cord

Publications for Pneumococcal Meningitis

Articles related to Pneumococcal Meningitis:

(show top 50) (show all 624)
# Title Authors Year
1
Antiphospholipid Syndrome Complicating Pneumococcal Meningitis. ( 29845960 )
2018
2
Cystic Encephalomalacia following Vasculopathy and Vasospasm of Proximal Intracranial Arteries Due to Pneumococcal Meningitis in a Infant. ( 29523004 )
2018
3
Adjuvant non-bacteriolytic and anti-inflammatory combination therapy in pneumococcal meningitis: an investigation in a mouse model. ( 29649601 )
2018
4
Pneumococcal meningitis trends after pneumococcal conjugate vaccine introduction in Colombia: An interrupted time-series analysis. ( 29351491 )
2018
5
Novel and preclinical treatment strategies in pneumococcal meningitis. ( 29095719 )
2018
6
Lesson learned through a case of pneumococcal meningitis: sometimes doing less is more harmful. ( 29928862 )
2018
7
Resveratrol Acts Anti-Inflammatory and Neuroprotective in an Infant Rat Model of Pneumococcal Meningitis by Modulating the Hippocampal miRNome. ( 29611100 )
2018
8
Pneumococcal Meningitis in Adults after Introduction of PCV7 and PCV13, Israel, July 2009-June 2015<sup>1</sup>. ( 29912694 )
2018
9
Reactive vaccination as a control strategy for pneumococcal meningitis outbreaks in the African meningitis belt: Analysis of outbreak data from Ghana. ( 29371015 )
2018
10
Early impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis-Burkina Faso, 2014-2015. ( 29253559 )
2018
11
Pneumococcal meningitis outbreak and associated factors in six districts of Brong Ahafo region, Ghana, 2016. ( 29929517 )
2018
12
Adult Patients with Pneumococcal Meningitis at a Neurosurgical Neurologic Center: Different Predisposing Conditions? ( 29170119 )
2018
13
Fatal Cerebellar Hemorrhage Complicating Pneumococcal Meningitis: Are Anticoagulants the Hidden Enemy? ( 29962752 )
2018
14
Delayed cerebral thrombosis complicating pneumococcal meningitis: an autopsy study. ( 29427117 )
2018
15
The cerebral protective effect and mechanism of action of vitamin B6 adjuvant ceftriaxone in experimental pneumococcal meningitis. ( 29800553 )
2018
16
B7-H3 Augments Inflammatory Responses and Exacerbates Brain Damage via Amplifying NF-I_B p65 and MAPK p38 Activation during Experimental Pneumococcal Meningitis. ( 28141831 )
2017
17
Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants. ( 28562692 )
2017
18
Role of purinergic signaling in experimental pneumococcal meningitis. ( 28300164 )
2017
19
Pneumococcal meningitis in Cantabria (Spain) in the pneumococcal conjugate vaccine era (2001-2015). ( 28318182 )
2017
20
Detection of Significant Pneumococcal Meningitis Biomarkers by Ego Network. ( 28247176 )
2017
21
The Early Adaptive Immune Response in the Pathophysiological Process of Pneumococcal Meningitis. ( 27803171 )
2017
22
Diagnostic Dilemma in a 15-Year-Old Boy with Recurrent Pneumococcal Meningitis. ( 28658867 )
2017
23
Impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis in children. ( 28711388 )
2017
24
Sporadic isolated congenital asplenia with fulminant pneumococcal meningitis: a case report and updated literature review. ( 29254492 )
2017
25
Pneumococcal meningitis-associated bihemispherical acute vasculitic infarcts. ( 28784909 )
2017
26
Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems. ( 28489958 )
2017
27
Surveillance of impact of PCV-10 vaccine on pneumococcal meningitis in Mozambique, 2013 - 2015. ( 28604773 )
2017
28
Case-control study shows that neonatal pneumococcal meningitis cannot be distinguished from group B Streptococcus cases. ( 28508419 )
2017
29
Trends in pneumococcal meningitis hospitalizations following the introduction of the 13-valent pneumococcal conjugate vaccine in the United States. ( 28951086 )
2017
30
Pneumococcal meningitis with normal cerebrospinal biochemistry and no pneumococci at microscopy, mimicking a stroke: a case report. ( 28592301 )
2017
31
Prevention of Memory Impairment and Neurotrophic Factors Increased by Lithium in Wistar Rats Submitted to Pneumococcal Meningitis Model. ( 29200666 )
2017
32
Risk Factors in Children Older Than 5 Years With Pneumococcal Meningitis: Data From a National Network. ( 28403047 )
2017
33
Quantitative Proteomics of Cerebrospinal Fluid in Paediatric Pneumococcal Meningitis. ( 28765563 )
2017
34
DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6. ( 29233148 )
2017
35
Can infant vaccination prevent pneumococcal meningitis outbreaks in sub-Saharan Africa? ( 28244176 )
2017
36
Pneumococcal Meningitis Before and After Universal Vaccination With Pneumococcal Conjugate Vaccines 7/13, Impact on Pediatric Hospitalization in Public and Nonpublic Institutions, in Uruguay. ( 28661966 )
2017
37
Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis. ( 29096648 )
2017
38
Pneumococcal meningitis and endocarditis in an infant: possible improved survival with factor V Leiden mutation. ( 28801724 )
2017
39
Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. ( 28086930 )
2017
40
Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case-control study. ( 29637127 )
2017
41
Variation of 46 Innate Immune Genes Evaluated for their Contribution in Pneumococcal Meningitis Susceptibility and Outcome. ( 27432718 )
2016
42
Exome Array Analysis of Susceptibility to Pneumococcal Meningitis. ( 27389768 )
2016
43
Edaravone attenuates hippocampal damage in an infant mouse model of pneumococcal meningitis by reducing HMGB1 and iNOS expression via the Nrf2/HO-1 pathway. ( 27569388 )
2016
44
Streptococcus pneumoniae capsule determines disease severity in experimental pneumococcal meningitis. ( 27009189 )
2016
45
Inhibition of Hippocampal Regeneration by Adjuvant Dexamethasone in Experimental Infant Rat Pneumococcal Meningitis. ( 26824948 )
2016
46
Cerebrovascular Complications of Pediatric Pneumococcal Meningitis in the PCV13 Era. ( 27247340 )
2016
47
V-akt murine thymoma viral oncogene homolog 3 (AKT3) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. ( 27193124 )
2016
48
Surgically Cured, Relapsed Pneumococcal Meningitis Due to Bone Defects, Non-invasively Identified by Three-dimensional Multi-detector Computed Tomography. ( 27980270 )
2016
49
Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis. ( 26976591 )
2016
50
An outbreak of pneumococcal meningitis among older children (a8Y5A years) and adults after the implementation of an infant vaccination programme with the 13-valent pneumococcal conjugate vaccine in Ghana. ( 27756235 )
2016

Variations for Pneumococcal Meningitis

Expression for Pneumococcal Meningitis

Search GEO for disease gene expression data for Pneumococcal Meningitis.

Pathways for Pneumococcal Meningitis

Pathways related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.59 MAPK10 MBL2 NFKBIE
2
Show member pathways
12.04 GLUL MAPK10 MMP9 NFKBIE
3
Show member pathways
12.03 MAPK10 MMP9 NFKBIE
4
Show member pathways
11.77 MAPK10 MMP9 NFKBIE
5
Show member pathways
11.64 MAPK10 NFKBIE
6
Show member pathways
11.63 MAPK10 MIF NFKBIE
7
Show member pathways
11.62 MAPK10 NFKBIE
8 11.6 MIF MMP9
9
Show member pathways
11.56 MAPK10 NFKBIE
10 11.53 MAPK10 MMP9
11
Show member pathways
11.4 MAPK10 NFKBIE
12 11.27 MAPK10 NFKBIE
13
Show member pathways
11.1 MAPK10 NFKBIE
14
Show member pathways
11.01 MAPK10 NFKBIE
15 10.74 MAPK10 NFKBIE
16
Show member pathways
10.6 MIF MMP9 NFKBIE

GO Terms for Pneumococcal Meningitis

Cellular components related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ficolin-1-rich granule lumen GO:1904813 8.62 MIF MMP9

Sources for Pneumococcal Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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