MCID: PNM013
MIFTS: 42

Pneumococcal Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pneumococcal Meningitis

MalaCards integrated aliases for Pneumococcal Meningitis:

Name: Pneumococcal Meningitis 59
Meningitis, Pneumococcal 73

Classifications:



External Ids:

Orphanet 59 ORPHA55655
ICD10 via Orphanet 34 G00.1
MESH via Orphanet 45 D008586
UMLS via Orphanet 74 C0025295
ICD10 33 G00.1
UMLS 73 C0025295

Summaries for Pneumococcal Meningitis

MalaCards based summary : Pneumococcal Meningitis, also known as meningitis, pneumococcal, is related to brain edema and meningitis. An important gene associated with Pneumococcal Meningitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are TNFR1 Pathway and Allograft rejection. Affiliated tissues include brain, testes and neutrophil, and related phenotype is behavior/neurological.

Related Diseases for Pneumococcal Meningitis

Diseases related to Pneumococcal Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 brain edema 30.0 GLUL MMP9
2 meningitis 11.3
3 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.4
4 endocarditis 10.2
5 brain injury 10.2
6 thrombosis 10.2
7 pneumonia 10.1
8 vasculitis 10.1
9 hydrocephalus 10.1
10 quadriplegia 10.1
11 otitis media 10.0
12 common variable immunodeficiency 10.0
13 sinusitis 10.0
14 sphenoid sinusitis 10.0
15 labyrinthitis 10.0
16 bacterial meningitis 10.0
17 sickle cell disease 10.0
18 head injury 10.0
19 lyme disease 9.9 C3 MMP9
20 dense deposit disease 9.9 C3 C5
21 complement deficiency 9.9 C3 C5
22 hemoglobinuria 9.9 C3 C5
23 hemolytic uremic syndrome, atypical 1 9.8 C3 C5
24 thrombophilia due to thrombin defect 9.8
25 stroke, ischemic 9.8
26 sickle cell anemia 9.8
27 west nile virus 9.8
28 malaria 9.8
29 complement component 3 deficiency, autosomal recessive 9.8
30 arthritis 9.8
31 cerebral hemorrhage 9.8
32 glomerulonephritis 9.8
33 hepatitis 9.8
34 cardiac arrest 9.8
35 sensorineural hearing loss 9.8
36 osteomyelitis 9.8
37 meningoencephalitis 9.8
38 intracranial aneurysm 9.8
39 hemiplegia 9.8
40 chlamydia 9.8
41 epidural abscess 9.8
42 cerebral arteritis 9.8
43 pulmonary edema 9.8
44 streptococcal meningitis 9.8
45 cauda equina syndrome 9.8
46 esophagitis 9.8
47 optic neuritis 9.8
48 aseptic meningitis 9.8
49 hemolytic-uremic syndrome 9.8
50 locked-in syndrome 9.8

Comorbidity relations with Pneumococcal Meningitis via Phenotypic Disease Network (PDN):


Otitis Media Respiratory Failure

Graphical network of the top 20 diseases related to Pneumococcal Meningitis:



Diseases related to Pneumococcal Meningitis

Symptoms & Phenotypes for Pneumococcal Meningitis

MGI Mouse Phenotypes related to Pneumococcal Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.02 C3 C5 GLUL KMO MMP9

Drugs & Therapeutics for Pneumococcal Meningitis

Search Clinical Trials , NIH Clinical Center for Pneumococcal Meningitis

Genetic Tests for Pneumococcal Meningitis

Anatomical Context for Pneumococcal Meningitis

MalaCards organs/tissues related to Pneumococcal Meningitis:

41
Brain, Testes, Neutrophil, Bone, Spinal Cord, Endothelial, Cortex

Publications for Pneumococcal Meningitis

Articles related to Pneumococcal Meningitis:

(show top 50) (show all 809)
# Title Authors Year
1
Antiphospholipid Syndrome Complicating Pneumococcal Meningitis. ( 29845960 )
2018
2
Cystic Encephalomalacia following Vasculopathy and Vasospasm of Proximal Intracranial Arteries Due to Pneumococcal Meningitis in a Infant. ( 29523004 )
2018
3
Adjuvant non-bacteriolytic and anti-inflammatory combination therapy in pneumococcal meningitis: an investigation in a mouse model. ( 29649601 )
2018
4
Pneumococcal meningitis trends after pneumococcal conjugate vaccine introduction in Colombia: An interrupted time-series analysis. ( 29351491 )
2018
5
Novel and preclinical treatment strategies in pneumococcal meningitis. ( 29095719 )
2018
6
Lesson learned through a case of pneumococcal meningitis: sometimes doing less is more harmful. ( 29928862 )
2018
7
Resveratrol Acts Anti-Inflammatory and Neuroprotective in an Infant Rat Model of Pneumococcal Meningitis by Modulating the Hippocampal miRNome. ( 29611100 )
2018
8
Pneumococcal Meningitis in Adults after Introduction of PCV7 and PCV13, Israel, July 2009-June 2015<sup>1</sup>. ( 29912694 )
2018
9
Reactive vaccination as a control strategy for pneumococcal meningitis outbreaks in the African meningitis belt: Analysis of outbreak data from Ghana. ( 29371015 )
2018
10
Early impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis-Burkina Faso, 2014-2015. ( 29253559 )
2018
11
Pneumococcal meningitis outbreak and associated factors in six districts of Brong Ahafo region, Ghana, 2016. ( 29929517 )
2018
12
Adult Patients with Pneumococcal Meningitis at a Neurosurgical Neurologic Center: Different Predisposing Conditions? ( 29170119 )
2018
13
Fatal Cerebellar Hemorrhage Complicating Pneumococcal Meningitis: Are Anticoagulants the Hidden Enemy? ( 29962752 )
2018
14
Delayed cerebral thrombosis complicating pneumococcal meningitis: an autopsy study. ( 29427117 )
2018
15
Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis. ( 30131074 )
2018
16
Catastrophic cerebral hemorrhage and edema in a patient with pneumococcal meningitis. ( 30216857 )
2018
17
Pneumococcal Meningitis Complicated by Cerebral Vasculitis, Abscess, Hydrocephalus, and Hearing Loss. ( 30410804 )
2018
18
Brain-targeted delivery of PEGylated nano-bacitracin A against Penicillin-sensitive and -resistant Pneumococcal meningitis: formulated with RVG29 and Pluronic® P85 unimers. ( 30404541 )
2018
19
Incidence of paediatric pneumococcal meningitis and emergence of new serotypes: a time-series analysis of a 16-year French national survey. ( 30049623 )
2018
20
Outbreak of Pneumococcal Meningitis, Paoua Subprefecture, Central African Republic, 2016-2017. ( 30124413 )
2018
21
Continued occurrence of serotype 1 pneumococcal meningitis in two regions located in the meningitis belt in Ghana five years after introduction of 13-valent pneumococcal conjugate vaccine. ( 30192772 )
2018
22
Late-onset cerebral vasculopathy complicating pneumococcal meningitis. A case report with unusual clinical features. ( 30195897 )
2018
23
The cerebral protective effect and mechanism of action of vitamin B6 adjuvant ceftriaxone in experimental pneumococcal meningitis. ( 29800553 )
2018
24
B7-H3 Augments Inflammatory Responses and Exacerbates Brain Damage via Amplifying NF-I_B p65 and MAPK p38 Activation during Experimental Pneumococcal Meningitis. ( 28141831 )
2017
25
Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants. ( 28562692 )
2017
26
Role of purinergic signaling in experimental pneumococcal meningitis. ( 28300164 )
2017
27
Pneumococcal meningitis in Cantabria (Spain) in the pneumococcal conjugate vaccine era (2001-2015). ( 28318182 )
2017
28
Detection of Significant Pneumococcal Meningitis Biomarkers by Ego Network. ( 28247176 )
2017
29
The Early Adaptive Immune Response in the Pathophysiological Process of Pneumococcal Meningitis. ( 27803171 )
2017
30
Diagnostic Dilemma in a 15-Year-Old Boy with Recurrent Pneumococcal Meningitis. ( 28658867 )
2017
31
Impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis in children. ( 28711388 )
2017
32
Sporadic isolated congenital asplenia with fulminant pneumococcal meningitis: a case report and updated literature review. ( 29254492 )
2017
33
Pneumococcal meningitis-associated bihemispherical acute vasculitic infarcts. ( 28784909 )
2017
34
Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems. ( 28489958 )
2017
35
Surveillance of impact of PCV-10 vaccine on pneumococcal meningitis in Mozambique, 2013 - 2015. ( 28604773 )
2017
36
Case-control study shows that neonatal pneumococcal meningitis cannot be distinguished from group B Streptococcus cases. ( 28508419 )
2017
37
Trends in pneumococcal meningitis hospitalizations following the introduction of the 13-valent pneumococcal conjugate vaccine in the United States. ( 28951086 )
2017
38
Pneumococcal meningitis with normal cerebrospinal biochemistry and no pneumococci at microscopy, mimicking a stroke: a case report. ( 28592301 )
2017
39
Prevention of Memory Impairment and Neurotrophic Factors Increased by Lithium in Wistar Rats Submitted to Pneumococcal Meningitis Model. ( 29200666 )
2017
40
Risk Factors in Children Older Than 5 Years With Pneumococcal Meningitis: Data From a National Network. ( 28403047 )
2017
41
Quantitative Proteomics of Cerebrospinal Fluid in Paediatric Pneumococcal Meningitis. ( 28765563 )
2017
42
DNA repair protein APE1 is involved in host response during pneumococcal meningitis and its expression can be modulated by vitamin B6. ( 29233148 )
2017
43
Can infant vaccination prevent pneumococcal meningitis outbreaks in sub-Saharan Africa? ( 28244176 )
2017
44
Pneumococcal Meningitis Before and After Universal Vaccination With Pneumococcal Conjugate Vaccines 7/13, Impact on Pediatric Hospitalization in Public and Nonpublic Institutions, in Uruguay. ( 28661966 )
2017
45
Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis. ( 29096648 )
2017
46
Pneumococcal meningitis and endocarditis in an infant: possible improved survival with factor V Leiden mutation. ( 28801724 )
2017
47
Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. ( 28086930 )
2017
48
Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case-control study. ( 29637127 )
2017
49
Intracranial mycotic aneurysm in a 5 month-old infant with pneumococcal meningitis. ( 27157377 )
2017
50
Erratum to: Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis. ( 28385159 )
2017

Variations for Pneumococcal Meningitis

Expression for Pneumococcal Meningitis

Search GEO for disease gene expression data for Pneumococcal Meningitis.

Pathways for Pneumococcal Meningitis

Pathways related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.45 GLUL MMP9 NFKBIE
2
Show member pathways
12.24 C3 C5 NFKBIE
3
Show member pathways
11.64 C3 C5
4 11.6 C3 C5
5
Show member pathways
11.56 C3 C5
6 11.48 C5 MMP9
7
Show member pathways
11.28 C3 C5
8
Show member pathways
11.06 MMP9 NFKBIE
9 11.04 C3 C5
10
Show member pathways
10.76 MMP9 NFKBIE
11 10.37 C3 C5

GO Terms for Pneumococcal Meningitis

Cellular components related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 C3 C5 KMO MMP9

Biological processes related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.37 C3 C5
2 negative regulation of endopeptidase activity GO:0010951 9.32 C3 C5
3 regulation of complement activation GO:0030449 9.26 C3 C5
4 complement activation GO:0006956 9.16 C3 C5
5 positive regulation of vascular endothelial growth factor production GO:0010575 8.96 C3 C5
6 complement activation, alternative pathway GO:0006957 8.62 C3 C5

Molecular functions related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.62 C3 C5

Sources for Pneumococcal Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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