MCID: PNM013
MIFTS: 43

Pneumococcal Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Pneumococcal Meningitis

MalaCards integrated aliases for Pneumococcal Meningitis:

Name: Pneumococcal Meningitis 58 17 32
Meningitis, Pneumococcal 71

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare infectious diseases


External Ids:

ICD10 32 G00.1
MESH via Orphanet 44 D008586
ICD10 via Orphanet 33 G00.1
UMLS via Orphanet 72 C0025295
Orphanet 58 ORPHA55655
UMLS 71 C0025295

Summaries for Pneumococcal Meningitis

MalaCards based summary : Pneumococcal Meningitis, also known as meningitis, pneumococcal, is related to bacterial meningitis and hemolytic-uremic syndrome. An important gene associated with Pneumococcal Meningitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Innate Immune System and TNFR1 Pathway. The drugs Phenytoin and Cefotaxime have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and neutrophil, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Pneumococcal Meningitis

Diseases related to Pneumococcal Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 bacterial meningitis 31.5 MMP9 C3
2 hemolytic-uremic syndrome 29.7 C5 C3
3 meningitis 11.4
4 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
5 ocular motor apraxia 10.6
6 branchiootic syndrome 1 10.5
7 vasculitis 10.5
8 otitis media 10.5
9 hydrocephalus 10.5
10 brain edema 10.5
11 sensorineural hearing loss 10.4
12 streptococcus pneumonia 10.4
13 haemophilus influenzae 10.4
14 mollaret meningitis 10.3
15 intracranial hypertension 10.3
16 hydrops, lactic acidosis, and sideroblastic anemia 10.3
17 endocarditis 10.3
18 labyrinthitis 10.3
19 head injury 10.3
20 meningococcal meningitis 10.3
21 bacterial infectious disease 10.3
22 meningoencephalitis 10.3
23 toxic shock syndrome 10.3
24 locked-in syndrome 10.2
25 mastoiditis 10.2
26 thrombosis 10.2
27 quadriplegia 10.2
28 pleural empyema 10.2
29 sickle cell disease 10.2
30 brain injury 10.2
31 thrombophilia due to thrombin defect 10.1
32 immune deficiency disease 10.1
33 mulchandani-bhoj-conlin syndrome 10.1
34 streptococcal meningitis 10.1
35 myelitis 10.1
36 purpura 10.1
37 paraplegia 10.1
38 48,xyyy 10.1
39 aneurysm 10.1
40 rare surgical neurologic disease 10.1
41 ataxia and polyneuropathy, adult-onset 10.1
42 sickle cell anemia 10.1
43 exanthem 10.1
44 disseminated intravascular coagulation 10.1
45 diarrhea 10.1
46 purulent labyrinthitis 10.1
47 status epilepticus 10.1
48 cerebritis 10.1
49 intracranial thrombosis 10.1
50 pneumonia 10.1

Comorbidity relations with Pneumococcal Meningitis via Phenotypic Disease Network (PDN):


Otitis Media Respiratory Failure

Graphical network of the top 20 diseases related to Pneumococcal Meningitis:



Diseases related to Pneumococcal Meningitis

Symptoms & Phenotypes for Pneumococcal Meningitis

MGI Mouse Phenotypes related to Pneumococcal Meningitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.85 AKT3 C3 C5 CASP1 CASP3 MMP9
2 cardiovascular system MP:0005385 9.83 AKT3 C3 CASP1 CASP3 MMP9
3 immune system MP:0005387 9.8 AKT3 C3 C5 CASP1 CASP3 MMP9
4 mortality/aging MP:0010768 9.73 AKT3 C3 C5 CASP1 CASP3 MMP9
5 digestive/alimentary MP:0005381 9.71 C3 CASP1 CASP3 MMP9
6 nervous system MP:0003631 9.63 AKT3 C3 C5 CASP1 CASP3 MMP9
7 renal/urinary system MP:0005367 9.26 C3 CASP1 CASP3 MMP9
8 reproductive system MP:0005389 9.02 AKT3 C3 CASP1 CASP3 MMP9

Drugs & Therapeutics for Pneumococcal Meningitis

Drugs for Pneumococcal Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
3
Acetaminophen Approved Phase 4 103-90-2 1983
4
Cefoxitin Approved Phase 4 35607-66-0 441199
5 Sodium Channel Blockers Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Anticonvulsants Phase 4
8 Diuretics, Potassium Sparing Phase 4
9 Anti-Bacterial Agents Phase 4
10 Anti-Infective Agents Phase 4
11 Analgesics, Non-Narcotic Phase 4
12 Antipyretics Phase 4
13 beta-Lactams Phase 4
14 Lactams Phase 4
15 Analgesics Phase 4
16 Immunoglobulins Phase 3
17 Antibodies Phase 3
18 Vaccines Phase 3
19 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
20 Immunologic Factors Phase 3
21
Ceftobiprole Approved, Investigational Phase 2 209467-52-7 6918430
22
Ceftobiprole medocaril Experimental, Investigational Phase 2 376653-43-9
23 Cephalosporins Phase 2
24
Daptomycin Approved, Investigational Phase 1 103060-53-3 16129629
25
Ceftriaxone Approved Phase 1 73384-59-5 5479530 5361919
26
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
27
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
28
Vancomycin Approved 1404-90-6 441141 14969
29
Fluconazole Approved, Investigational 86386-73-4 3365
30 Antiemetics
31 BB 1101
32 Autonomic Agents
33 Hormone Antagonists
34 Gastrointestinal Agents
35 Anti-Inflammatory Agents
36 Antineoplastic Agents, Hormonal
37 glucocorticoids
38 Hormones

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. A Multi-center Comparative Randomized Double-blind and Placebo-controlled Clinical Trial Unknown status NCT01478035 Phase 4 Phenytoin;placebo
2 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis, Especially of Pneumococcal Meningitis, in Angola. Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
3 A Study of Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines to Inform Policy Regarding Pneumococcal Vaccination of Papua New Guinean Children Unknown status NCT01619462 Phase 3
4 An Alternative Booster Vaccine Against Meningitis and Ear Infections. Completed NCT01443416 Phase 3
5 Impact of the 7 Valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Carriage of S. Pneumoniae in Healthy Jordanian Infants. Unknown status NCT00900978 Phase 1, Phase 2
6 Neonatal Immunization With Pneumococcal Conjugate Vaccine in Papua New Guinea Completed NCT00219401 Phase 2
7 Adjunction of Daptomycin for the Treatment of Pneumococcal Meningitis: AddaMAP Study Recruiting NCT03480191 Phase 2 Daptomycin
8 Open and Exploratory Trial to Investigate the Pharmacokinetic of Ceftobiprole Medocaril in Patients With CSF Device Recruiting NCT03317093 Phase 2 Ceftobiprole Medocaril
9 Dynamics of the Immune Response in Children to the 23-valent Pneumococcal Capsular Polysaccharide Vaccine (Pneumovax) Completed NCT03460730 Phase 1
10 Evaluation of Cerebrospinal Fluid Concentration of Daptomycin (Cubicin¬) in Pediatric Patients With Gram-positive Bacterial Meningitis, Concurrently Receiving Standard Antimicrobial Therapy Terminated NCT01522105 Phase 1 Daptomycin
11 Prevalence of Pneumococcal Meningitis in the Paediatric Population in Spain Four Years After the Marketing of Prevenar. Completed NCT00227214
12 Vancomycin Concentration in Cerebrospinal Fluid During Pneumococcal Meningitis Treated With Dexamethasone Completed NCT00162578
13 Incidence And Serotypes Of Invasive Pneumococcal Disease, After The Introduction Of The Heptavalent Conjugated Vaccine In Greece Completed NCT01111214
14 Observational Study of the Immunogenicity of Heptavalent Pneumococcal Conjugate Vaccine in Very-low-birth-weight Infants Completed NCT00273325
15 Surveillance of Invasive Pneumococcal Infections in Adults (Excluding Meningitis) Recruiting NCT03983616
16 Pneumococcal Conjugate Vaccine 13 (PCV13) Schedule Change From 3+0 to 2+1 to Accelerate Reduction in Pneumococcal Vaccine Serotype Carriage in Blantyre, Malawi: an Effectiveness Study Not yet recruiting NCT04078997
17 Continuation of the Costa Rican Epidemiologic Surveillance for Invasive Pneumococcal Disease After Introduction of the Seven Valent Vaccine Into the Universal Vaccination Program Suspended NCT01308827

Search NIH Clinical Center for Pneumococcal Meningitis

Genetic Tests for Pneumococcal Meningitis

Anatomical Context for Pneumococcal Meningitis

MalaCards organs/tissues related to Pneumococcal Meningitis:

40
Brain, Spinal Cord, Neutrophil, Testes, Bone, Monocytes, Cortex

Publications for Pneumococcal Meningitis

Articles related to Pneumococcal Meningitis:

(show top 50) (show all 1851)
# Title Authors PMID Year
1
New Strategy Is Needed to Prevent Pneumococcal Meningitis. 61
32032170 2020
2
Lower respiratory infections mortality among Brazilians under-five before and after national pneumococcal conjugate vaccine implementation. 61
32033849 2020
3
Recurrent Pneumococcal Meningitis Secondary to Nasoethmoidal Meningocele. 61
31876613 2020
4
Resurgence of pneumococcal meningitis in Europe and Northern America. 61
31100424 2020
5
Long-term neurological and cognitive outcome, and quality of life in adults after pneumococcal meningitis. 61
32006689 2020
6
Association of toll-like receptor 10 polymorphisms with pediatric pneumococcal meningitis. 61
31976578 2020
7
Diagnostic Yield of Pneumococcal Antigen Detection in Cerebrospinal Fluid for Diagnosis of Pneumococcal Meningitis Among Children in China. 61
31937696 2020
8
Delayed cerebral vasculitis associated with the development of ceftriaxone resistant pneumococcal meningitis. 61
31907185 2020
9
Changing Epidemiology and Predisposing Factors for Invasive Pneumococcal Disease at Two Australian Tertiary Hospitals. 61
31815835 2020
10
Mortality from HIV-associated meningitis in sub-Saharan Africa: a systematic review and meta-analysis. 61
31957332 2020
11
Acromioclavicular joint arthritis as the first manifestation of Austrian syndrome. 61
31300377 2020
12
Complication of otitis media leads to opisthotonos in a toddler. 61
31987742 2020
13
Molecular serotype-specific identification of Streptococcus pneumoniae using loop-mediated isothermal amplification. 61
31882619 2019
14
Neutrophil Extracellular Traps (NETs) in the Cerebrospinal Fluid Samples from Children and Adults with Central Nervous System Infections. 61
31877982 2019
15
Invasive Pneumococcal and Meningococcal Disease. 61
31668194 2019
16
The clinical implication of serotype distribution and drug resistance of invasive pneumococcal disease in children: A single center study in southern Taiwan during 2010-2016. 61
31103534 2019
17
Complement factor H contributes to mortality in humans and mice with bacterial meningitis. 61
31883521 2019
18
Hospital cost of invasive pneumococcal disease in children aged under 15 years old in Tunisia. 61
32003444 2019
19
Emerging non-13-valent pneumococcal conjugate vaccine (PCV13) serotypes causing adult invasive pneumococcal disease in the late-PCV13 period in Spain. 61
31756452 2019
20
AN AUDIT OF ADJUNCTIVE STEROID USE FOR PNEUMOCOCCAL MENINGITIS AT A TERTIARY HOSPITAL IN SYDNEY, AUSTRALIA FROM 2005 TO 2015. 61
31691427 2019
21
Double deficiency of toll-like receptors 2 and 4 alters long-term neurological sequelae in mice cured of pneumococcal meningitis. 61
31700009 2019
22
New Virulence Factors Identified in Pneumococcal Meningitis. 61
31506191 2019
23
Emergence of ceftriaxone resistance during a pneumococcal meningitis with fatal evolution. 61
31712218 2019
24
Targeting the complement system in bacterial meningitis. 61
31373605 2019
25
Cost-effectiveness of introducing the pneumococcal conjugate vaccine for children under 5 years in the Islamic Republic of Iran. 61
31774134 2019
26
Impact of 13-Valent Pneumococcal Conjugate Vaccine on Pneumococcal Meningitis, Burkina Faso, 2016-2017. 61
31671444 2019
27
Meningitis vaccines in children: what have we achieved and where next? 61
31335439 2019
28
Sustained reductions of invasive infectious disease following general infant Haemophilus influenzae type b and pneumococcal vaccination in a Swedish Arctic region. 61
31025393 2019
29
[Meningitis Due to Streptococcus pneumoniae Serotype 24B in a Patient with Cochlear Implant Previously Vaccinated with the Pneumococcal Vaccine]. 61
31709942 2019
30
Protein Oxidation Biomarkers and Myeloperoxidase Activation in Cerebrospinal Fluid in Childhood Bacterial Meningitis. 61
31581487 2019
31
Effect of Pneumococcal Conjugate Vaccines on Pneumococcal Meningitis, England and Wales, July 1, 2000-June 30, 2016. 61
31441745 2019
32
Can pneumococcal meningitis surveillance be used to assess the impact of pneumococcal conjugate vaccine on total invasive pneumococcal disease? A case-study from South Africa, 2005-2016. 61
31076159 2019
33
Impact of 10-Valent Pneumococcal Conjugate Vaccine on Bacterial Meningitis in Madagascar. 61
31505632 2019
34
Hospital-based Surveillance for Pediatric Bacterial Meningitis in the Era of the 13-Valent Pneumococcal Conjugate Vaccine in Ghana. 61
31505622 2019
35
Etiology of Pediatric Bacterial Meningitis Pre- and Post-PCV13 Introduction Among Children Under 5 Years Old in Lomé, Togo. 61
31505623 2019
36
Pediatric Bacterial Meningitis Surveillance in Nigeria From 2010 to 2016, Prior to and During the Phased Introduction of the 10-Valent Pneumococcal Conjugate Vaccine. 61
31505626 2019
37
Pediatric Bacterial Meningitis Surveillance in the World Health Organization African Region Using the Invasive Bacterial Vaccine-Preventable Disease Surveillance Network, 2011-2016. 61
31505629 2019
38
Declines in Pediatric Bacterial Meningitis in the Republic of Benin Following Introduction of Pneumococcal Conjugate Vaccine: Epidemiological and Etiological Findings, 2011-2016. 61
31505630 2019
39
Declining Trends of Pneumococcal Meningitis in Gambian Children After the Introduction of Pneumococcal Conjugate Vaccines. 61
31505634 2019
40
Pneumococcal Conjugate Vaccine Impact on Meningitis and Pneumonia Among Children Aged <5 Years-Zimbabwe, 2010-2016. 61
31505631 2019
41
Recurrent Pneumococcal Meningitis in Children: A Multicenter Case-control Study. 61
31220046 2019
42
The art of partnerships for vaccines. 61
31447125 2019
43
Reactive vaccination as a control strategy for pneumococcal meningitis outbreaks in the African meningitis belt: Analysis of outbreak data from Ghana. 61
29371015 2019
44
Changes in the Molecular Epidemiology of Pediatric Bacterial Meningitis in Senegal After Pneumococcal Conjugate Vaccine Introduction. 61
31505635 2019
45
Causes of Pediatric Meningitis in Botswana: Results From a 16-Year National Meningitis Audit. 61
31261367 2019
46
[Extra-ventricular drainage for the treatment of pneumococcal meningitis and hydrocephalus: a case report]. 61
31474646 2019
47
Prevalence of Immunodeficiency in Children With Invasive Pneumococcal Disease in the Pneumococcal Vaccine Era: A Systematic Review. 61
31566672 2019
48
Rapid Streptococcus Pneumonia Antigen Detection on Postmortem Urine in a Death Due to Pneumococcal Meningitis. 61
30663991 2019
49
Association of Pneumococcal Conjugate Vaccine Coverage With Pneumococcal Meningitis: An Analysis of French Administrative Areas, 2001-2016. 61
31197305 2019
50
MMPs and ADAMs in neurological infectious diseases and multiple sclerosis. 61
31172218 2019

Variations for Pneumococcal Meningitis

Expression for Pneumococcal Meningitis

Search GEO for disease gene expression data for Pneumococcal Meningitis.

Pathways for Pneumococcal Meningitis

Pathways related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 MMP9 CASP3 CASP1 C5 C3 AKT3
2
Show member pathways
12.61 MMP9 CASP3 CASP1 AKT3
3
Show member pathways
12.57 MMP9 CASP3 AKT3
4 12.54 MMP9 CASP3 AKT3
5
Show member pathways
12.54 CASP3 C5 C3
6
Show member pathways
12.5 CASP3 CASP1 AKT3
7
Show member pathways
12.49 CASP3 CASP1 AKT3
8
Show member pathways
12.49 MMP9 CASP3 CASP1 C3 AKT3
9 12.44 CASP3 CASP1 AKT3
10 12.31 CASP3 C5 C3 AKT3
11
Show member pathways
12.22 CASP3 CASP1 AKT3
12 12.09 CASP1 C3 AKT3
13 11.98 MMP9 CASP3 AKT3
14
Show member pathways
11.93 CASP3 C3 AKT3
15
Show member pathways
11.91 CASP3 CASP1 AKT3
16 11.86 CASP3 C3 AKT3
17
Show member pathways
11.84 CASP3 CASP1 AKT3
18 11.62 MMP9 CASP3 C5
19 11.61 CASP3 AKT3
20
Show member pathways
11.55 CASP3 AKT3
21
Show member pathways
11.54 CASP3 AKT3
22 11.48 MMP9 CASP3 AKT3
23 11.47 CASP3 AKT3
24 11.41 MMP9 CASP3
25 11.4 MMP9 CASP3
26 11.34 MMP9 CASP3
27 11.17 CASP3 AKT3
28 11.06 CASP3 CASP1
29 10.89 CASP3 CASP1 C3
30 10.81 CASP3 CASP1 C5 C3

GO Terms for Pneumococcal Meningitis

Biological processes related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.43 MMP9 CASP3 CASP1
2 apoptotic signaling pathway GO:0097190 9.37 CASP3 CASP1
3 cellular response to organic substance GO:0071310 9.32 CASP3 CASP1
4 positive regulation of vascular endothelial growth factor production GO:0010575 9.16 C5 C3
5 positive regulation of angiogenesis GO:0045766 9.13 C5 C3 AKT3
6 complement activation, alternative pathway GO:0006957 8.62 C5 C3

Molecular functions related to Pneumococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.5 MMP9 CASP3 CASP1
2 endopeptidase activity GO:0004175 9.26 MMP9 CASP1
3 endopeptidase inhibitor activity GO:0004866 9.16 C5 C3
4 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 8.96 CASP3 CASP1
5 cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097199 8.62 CASP3 CASP1

Sources for Pneumococcal Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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