MCID: PNM006
MIFTS: 54

Pneumoconiosis

Categories: Respiratory diseases

Aliases & Classifications for Pneumoconiosis

MalaCards integrated aliases for Pneumoconiosis:

Name: Pneumoconiosis 12 77 56 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10316
ICD9CM 36 505
MeSH 45 D011009
NCIt 51 C26861
SNOMED-CT 69 40122008
ICD10 34 J64
UMLS 74 C0032273

Summaries for Pneumoconiosis

Disease Ontology : 12 An interstitial lung disease that is caused by the inhalation of dust.

MalaCards based summary : Pneumoconiosis is related to anthracosis and asbestosis. An important gene associated with Pneumoconiosis is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Iron and Nutrients have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Pneumoconiosis is the general term for a class of interstitial lung diseases where inhalation of dust... more...

Related Diseases for Pneumoconiosis

Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 anthracosis 33.9 CCL2 SOD1 TNF
2 asbestosis 32.4 GSTM1 IL6 SERPINA1
3 silicosis 32.1 CCL2 CXCL8 FAS FASLG IL1B NLRP3
4 bronchitis 30.8 CXCL8 SERPINA1 TNF
5 arteries, anomalies of 30.5 CCL2 IL1B IL6 TNF
6 pneumonia 30.3 CCL2 CXCL8 IL1B IL6 TNF
7 pulmonary edema 30.3 CXCL8 IL1B TNF
8 endocarditis 30.3 CXCL8 IL6 TNF
9 arthritis 30.3 CCL2 CXCL8 IL1B IL6 TGFB1 TNF
10 peptic ulcer disease 30.1 CXCL8 IL1B TNF
11 respiratory failure 30.0 CXCL8 SERPINA1 TNF
12 pulmonary fibrosis, idiopathic 29.8 CCL2 CXCL8 FASLG IL1B TGFB1 TNF
13 heart disease 29.8 CXCL8 H19 IL1B IL6 TNF
14 lung disease 29.7 CCL2 CXCL8 IL1B IL6 SERPINA1 TGFB1
15 rheumatoid arthritis 29.6 CAT CCL2 CXCL8 H19 IL1B IL6
16 pulmonary disease, chronic obstructive 29.4 CCL2 CXCL8 GSTM1 IL6 SERPINA1 TGFB1
17 kaolin pneumoconiosis 12.5
18 pneumoconiosis due to talc 12.4
19 graphite pneumoconiosis 12.2
20 mixed mineral dust pneumoconiosis 12.1
21 labrador lung 12.1
22 slate pneumoconiosis 12.0
23 caplan's syndrome 12.0
24 aluminosis 11.8
25 silicosiderosis 11.8
26 baritosis 11.6
27 berylliosis 11.6
28 siderosis 11.4
29 nontuberculous mycobacterial lung disease 11.0
30 asbestos intoxication 10.9
31 anthracosilicosis 10.6
32 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
33 critical limb ischemia 10.5 IL6 TNF
34 staphylococcal toxic shock syndrome 10.5 IL1B TNF
35 autoimmune myocarditis 10.5 IL6 TNF
36 leukomalacia 10.5 IL6 TNF
37 scorpion envenomation 10.5 IL6 TNF
38 periodontitis, chronic 10.5 IL1B IL6
39 burn scar 10.5 FAS TGFB1
40 lung cancer 10.5
41 purulent labyrinthitis 10.5 CCL2 IL1B
42 tungiasis 10.5 CXCL8 TNF
43 leukoregulin 10.5 CXCL8 TGFB1
44 chronic venous leg ulcers 10.5 FAS FASLG
45 lymphocytic gastritis 10.5 FAS FASLG
46 acute transverse myelitis 10.5 CXCL8 IL6
47 cerebral palsy 10.4 IL1B IL6 TNF
48 pertussis 10.4 IL1B IL6 TNF
49 lyme disease 10.4 IL1B IL6 TNF
50 chronic mucocutaneous candidiasis 10.4 IL1B IL6 TNF

Comorbidity relations with Pneumoconiosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Chronic Myocardial Ischemia Familial Atrial Fibrillation
Heart Disease Ischemic Heart Disease
Postinflammatory Pulmonary Fibrosis Prostatic Hypertrophy
Respiratory Failure

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to Pneumoconiosis

Symptoms & Phenotypes for Pneumoconiosis

GenomeRNAi Phenotypes related to Pneumoconiosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 CASP8 CXCL8 FAS IL1B NLRP3 SOD1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 CASP8 CXCL8 FAS IL1B NLRP3 SOD1
3 Reduced mammosphere formation GR00396-S 9.56 CCL2 CXCL8 FAS FASLG GSTM1 H19

MGI Mouse Phenotypes related to Pneumoconiosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 CASP8 CAT CP FAS FASLG FN1
2 cardiovascular system MP:0005385 10.18 CASP8 CP FAS FASLG FN1 IL1B
3 homeostasis/metabolism MP:0005376 10.18 CASP8 CAT CP FAS FASLG FN1
4 hematopoietic system MP:0005397 10.17 CASP8 CP FAS FASLG FN1 IL1B
5 immune system MP:0005387 10.15 CASP8 CCL2 CP FAS FASLG FN1
6 integument MP:0010771 10.02 CASP8 FAS FASLG FN1 IL1B IL6
7 liver/biliary system MP:0005370 9.96 CASP8 CP FAS FASLG FN1 IL6
8 neoplasm MP:0002006 9.85 CASP8 CAT FAS FASLG FN1 IL1B
9 nervous system MP:0003631 9.7 CASP8 CP FAS FASLG FN1 IL1B
10 skeleton MP:0005390 9.28 FAS FASLG FN1 IL1B IL6 NLRP3

Drugs & Therapeutics for Pneumoconiosis

Drugs for Pneumoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 27284 23925
2 Nutrients Phase 4
3 Micronutrients Phase 4
4 Liver Extracts Phase 4
5 Trace Elements Phase 4
6
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
7
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
8
Isoniazid Approved, Investigational Phase 3,Not Applicable 54-85-3 3767
9
Rifampicin Approved Phase 3,Not Applicable 13292-46-1 5381226 5458213
10
Rifapentine Approved, Investigational Phase 3,Not Applicable 61379-65-5 6323497
11
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
12 Calcium, Dietary Phase 2, Phase 3
13 Adrenergic Agents Phase 2, Phase 3
14 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
15 Sympatholytics Phase 2, Phase 3
16 Neurotransmitter Agents Phase 2, Phase 3
17 Anti-Arrhythmia Agents Phase 2, Phase 3
18 Hormones Phase 2, Phase 3
19 calcium channel blockers Phase 2, Phase 3
20 Adrenergic Antagonists Phase 2, Phase 3
21 Vasodilator Agents Phase 2, Phase 3
22 Autonomic Agents Phase 2, Phase 3
23 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
24 Antihypertensive Agents Phase 2, Phase 3
25 Adrenergic beta-Antagonists Phase 2, Phase 3
26 Anti-Bacterial Agents Phase 3,Not Applicable
27 Antimetabolites Phase 3,Not Applicable
28 Nucleic Acid Synthesis Inhibitors Phase 3,Not Applicable
29 Antibiotics, Antitubercular Phase 3,Not Applicable
30 Cytochrome P-450 CYP3A Inducers Phase 3,Not Applicable
31 Antitubercular Agents Phase 3,Not Applicable
32 Lipid Regulating Agents Phase 3,Not Applicable
33 Hypolipidemic Agents Phase 3,Not Applicable
34 Anti-Infective Agents Phase 3,Not Applicable
35 Immunologic Factors Phase 3
36 Vaccines Phase 3
37
Infliximab Approved Phase 1, Phase 2 170277-31-3
38 Mitogens Phase 1, Phase 2
39 Anti-Inflammatory Agents Phase 1, Phase 2
40 Antirheumatic Agents Phase 1, Phase 2,Phase 2
41 Analgesics, Non-Narcotic Phase 1, Phase 2
42 Mesalamine Phase 1, Phase 2 89-57-6
43 Analgesics Phase 1, Phase 2
44 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
45 Gastrointestinal Agents Phase 1, Phase 2
46 Dermatologic Agents Phase 1, Phase 2
47
Heparin Approved, Investigational 9005-49-6 46507594 772
48
Deferiprone Approved 30652-11-0 2972
49 Xenon Experimental Early Phase 1 7440-63-3
50 Pharmaceutical Solutions

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome Unknown status NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
3 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Unknown status NCT02430259 Phase 3 Weekly INH / RRT given by DOT
4 Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older Completed NCT00753272 Phase 3
5 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
6 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
7 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
8 Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Unknown status NCT02790762 Phase 1
9 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
10 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Active, not recruiting NCT02668068 Phase 1
11 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Unknown status NCT02596347
12 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343
13 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
14 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
15 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
16 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
17 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
18 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
19 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Completed NCT01284127
20 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
21 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
22 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
23 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
24 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693
25 Short Course Rifapentine and Isoniazid for the Preventive Treatment of Tuberculosis(SCRIPT-TB) Recruiting NCT03900858 Not Applicable Isoniazid;Rifapentine
26 Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. Recruiting NCT03464344 Not Applicable
27 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
28 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6

Search NIH Clinical Center for Pneumoconiosis

Cochrane evidence based reviews: pneumoconiosis

Genetic Tests for Pneumoconiosis

Anatomical Context for Pneumoconiosis

MalaCards organs/tissues related to Pneumoconiosis:

42
Lung, Bone, Testes, Bone Marrow, Eye, Monocytes, Skin

Publications for Pneumoconiosis

Articles related to Pneumoconiosis:

(show top 50) (show all 1297)
# Title Authors Year
1
Prediction of pneumoconiosis by serum and urinary biomarkers in workers exposed to asbestos-contaminated minerals. ( 30946771 )
2019
2
Characteristics and Trends of Pneumoconiosis in the Jiangsu Province, China, 2006⁻2017. ( 30717363 )
2019
3
Prevalence of pneumoconiosis among young adults aged 24-44 years in a heavily industrialized province of China. ( 30698344 )
2019
4
Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study. ( 30674606 )
2019
5
Progressive plasterer's pneumoconiosis complicated by fibrotic interstitial pneumonia: a case report. ( 30616611 )
2019
6
TNF-α-TNFR signal pathway inhibits autophagy and promotes apoptosis of alveolar macrophages in coal worker's pneumoconiosis. ( 30467847 )
2019
7
Mixed-dust pneumoconiosis: Review of diagnostic and classification problems with presentation of a work-related case. ( 30368172 )
2019
8
Extracellular Histones Promote Pulmonary Fibrosis in Patients With Coal Workers' Pneumoconiosis. ( 30308624 )
2019
9
Both-sided native valve infective endocarditis in a drug addict with incidental pneumoconiosis. ( 29704724 )
2018
10
Estimated economic costs of coal workers' pneumoconiosis among coal workers redeployed from the Fuxin mining group in China. ( 29116190 )
2018
11
Coal miner participation in a job transfer program designed to prevent progression of pneumoconiosis, United States, 1986-2016. ( 29116886 )
2018
12
Prevalence and characteristics of COPD among pneumoconiosis patients at an occupational disease prevention institute: a cross-sectional study. ( 29378587 )
2018
13
Association Analysis Identifies New Risk Loci for Coal Workers' Pneumoconiosis in Han Chinese Men. ( 29394417 )
2018
14
Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269. ( 29415464 )
2018
15
Progressive massive fibrosis in patients with pneumoconiosis: utility of MRI in differentiating from lung cancer. ( 28361545 )
2018
16
Association of single nucleotide polymorphisms in the CYBA gene with coal workers' pneumoconiosis in the Han Chinese population. ( 30654669 )
2018
17
Combined silicosis and mixed dust pneumoconiosis with rapid progression: A case report and literature review. ( 30613676 )
2018
18
Comparison of the International Classification of High-resolution Computed Tomography for Occupational and Environmental Respiratory Diseases with the International Labor Organization International Classification of Radiographs of Pneumoconiosis. ( 30344228 )
2018
19
Computed tomography findings of arc-welders' pneumoconiosis: Comparison with silicosis. ( 30292280 )
2018
20
Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population. ( 30257124 )
2018
21
A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis. ( 30128271 )
2018
22
Time trends and future prediction of coal worker's pneumoconiosis in opencast coal mine in China based on the APC model. ( 30107832 )
2018
23
Outcomes of community-based and home-based pulmonary rehabilitation for pneumoconiosis patients: a retrospective study. ( 30092783 )
2018
24
Upregulated has-miR-4516 as a potential biomarker for early diagnosis of dust-induced pulmonary fibrosis in patients with pneumoconiosis. ( 30090591 )
2018
25
Coal Workers' Pneumoconiosis-Attributable Years of Potential Life Lost to Life Expectancy and Potential Life Lost Before Age 65 Years - United States, 1999-2016. ( 30070982 )
2018
26
Continued Increase in Prevalence of Coal Workers' Pneumoconiosis in the United States, 1970-2017. ( 30024799 )
2018
27
Pneumoconiosis in a polytetrafluoroethylene (PTFE) spray worker: a case report with an occupational hygiene study. ( 29992029 )
2018
28
WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis. ( 29958118 )
2018
29
Assessment of physicians' proficiency in reading chest radiographs for pneumoconiosis, based on a 60-film examination set with two factors constituting eight indices. ( 29806618 )
2018
30
Dental Technicians' Pneumoconiosis; Illness Behind a Healthy Smile - Case Series of a Reference Center in Turkey. ( 29743783 )
2018
31
Continued increase in lung transplantation for coal workers' pneumoconiosis in the United States. ( 29732582 )
2018
32
Prevalence of latent tuberculosis infection among coal workers' pneumoconiosis patients in China: a cross-sectional study. ( 29642880 )
2018
33
Establishment and application of an index system for prevention of coal workers' pneumoconiosis: a Delphi and analytic hierarchy process study in four state-owned coal enterprises of China. ( 29563194 )
2018
34
A response to the Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269 by the Author Mei Yong. ( 29438277 )
2018
35
TNFR/TNF-α signaling pathway regulates apoptosis of alveolar macrophages in coal workers' pneumoconiosis. ( 29416696 )
2018
36
Mica pneumoconiosis: a neglected occupational lung disease. ( 29759917 )
2018
37
Should hut lung be called domestically acquired particulate lung disease or domestically acquired pneumoconiosis? ( 29487788 )
2018
38
Erratum to "Wood Charcoal Dust Pneumoconiosis". ( 29274923 )
2017
39
Development of breath test for pneumoconiosis: a case-control study. ( 29041938 )
2017
40
Dental Technicians' Pneumoconiosis. ( 29021460 )
2017
41
Squamous cell carcinoma of the lung showing a ground glass nodule on high-resolution computed tomography associated with pneumoconiosis: a case report. ( 28963659 )
2017
42
LRBA Gene Polymorphisms and Risk of Coal Workers' Pneumoconiosis: A Case-Control Study from China. ( 28953250 )
2017
43
Loss of regulatory characteristics in CD4+ CD25+/hi T cells induced by impaired transforming growth factor beta secretion in pneumoconiosis. ( 28913840 )
2017
44
Element-based prognostics of occupational pneumoconiosis using micro-proton-induced X-ray emission analysis. ( 28912379 )
2017
45
Polymorphisms in autophagy related genes and the coal workers' pneumoconiosis in a Chinese population. ( 28844669 )
2017
46
Diagnostic accuracy of breath tests for pneumoconiosis using an electronic nose. ( 28795953 )
2017
47
TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis. ( 28698801 )
2017
48
Increasing Severity of Pneumoconiosis Among Younger Former US Coal Miners Working Exclusively Under Modern Dust-Control Regulations. ( 28598937 )
2017
49
Diagnostic and clinical application value of magnetic resonance imaging (MRI) for progressive massive fibrosis of coal worker pneumoconiosis: Case reports. ( 28514304 )
2017
50
Survival Analysis of Coal Workers' Pneumoconiosis (CWP) Patients in a State-Owned Mine in the East of China from 1963 to 2014. ( 28481235 )
2017

Variations for Pneumoconiosis

Expression for Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for Pneumoconiosis

Pathways related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 CASP8 CAT CCL2 CXCL8 FASLG FN1
2
Show member pathways
13.92 CASP8 CCL2 CXCL8 FAS FASLG FN1
3
Show member pathways
13.74 CASP8 CCL2 CXCL8 FAS FASLG IL1B
4
Show member pathways
13.61 CASP8 CXCL8 FAS FASLG IL1B IL6
5
Show member pathways
13.47 CCL2 CXCL8 FAS FASLG IL1B IL6
6
Show member pathways
13.41 CCL2 CXCL8 FASLG FN1 IL1B IL6
7
Show member pathways
13.36 CASP8 CCL2 CXCL8 FAS FASLG IL1B
8
Show member pathways
13.06 CASP8 FAS FASLG FN1 IL6 TNF
9
Show member pathways
13.02 CASP8 CCL2 FAS FASLG FN1 IL6
10
Show member pathways
13 CASP8 CCL2 CXCL8 FAS FASLG IL1B
11
Show member pathways
13 CASP8 CCL2 CXCL8 FAS FASLG IL1B
12
Show member pathways
12.9 CASP8 CXCL8 FAS FASLG HSPA1L IL1B
13 12.89 CASP8 CXCL8 FAS FASLG FN1 GSTM1
14 12.84 CASP8 FAS FASLG HSPA1L IL1B TGFB1
15
Show member pathways
12.82 CASP8 CXCL8 IL1B IL6 TNF
16
Show member pathways
12.75 CASP8 FAS FASLG IL1B TNF
17
Show member pathways
12.7 CASP8 FAS FASLG FN1 IL1B TNF
18
Show member pathways
12.66 CCL2 FN1 IL1B IL6 TNF
19 12.64 CCL2 FAS FASLG IL1B TNF
20
Show member pathways
12.63 FAS IL1B IL6 TGFB1 TNF
21
Show member pathways
12.53 CASP8 FAS FASLG TNF
22
Show member pathways
12.43 CAT CCL2 IL1B IL6 SOD1 TNF
23
Show member pathways
12.43 CASP8 CCL2 CXCL8 IL1B IL6 TNF
24
Show member pathways
12.39 CASP8 FAS FASLG TNF
25 12.39 FAS FASLG FN1 TGFB1 TNF
26
Show member pathways
12.36 CXCL8 IL1B IL6 TNF
27
Show member pathways
12.34 CXCL8 IL1B IL6 TGFB1 TNF
28
Show member pathways
12.34 CASP8 HSPA1L IL1B TGFB1 TNF
29
Show member pathways
12.32 CASP8 FAS FASLG TNF
30 12.32 CASP8 FAS FASLG TNF
31 12.32 CASP8 IL1B IL6 TGFB1 TNF
32
Show member pathways
12.31 CP CXCL8 IL1B IL6 TNF
33
Show member pathways
12.3 CASP8 IL1B IL6 NLRP3 TNF
34
Show member pathways
12.3 CASP8 FAS FASLG IL1B NLRP3 TNF
35 12.25 CXCL8 IL1B IL6 TNF
36 12.17 CCL2 GSTM1 IL1B TNF
37
Show member pathways
12.17 CXCL8 FAS FASLG FN1 IL1B IL6
38
Show member pathways
12.16 CAT FASLG IL6 TGFB1
39
Show member pathways
12.15 CCL2 CXCL8 IL1B IL6 TGFB1
40 12.14 FAS IL6 TGFB1 TNF
41
Show member pathways
12.14 FN1 IL1B IL6 SOD1 TNF
42
Show member pathways
12.13 IL1B IL6 TGFB1 TNF
43 12.08 CCL2 CXCL8 IL1B IL6 TGFB1 TNF
44 12.05 CXCL8 FN1 IL1B IL6 TGFB1
45 12.01 CASP8 CCL2 FAS IL1B IL6 TNF
46 11.94 CXCL8 IL1B TNF
47 11.94 CXCL8 FN1 IL1B IL6 TGFB1 TNF
48 11.93 IL1B IL6 TNF
49
Show member pathways
11.91 CXCL8 IL6 TGFB1
50 11.88 CXCL8 IL1B IL6 NLRP3 TNF

GO Terms for Pneumoconiosis

Cellular components related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.73 CP FN1 IL6 SERPINA1
2 extracellular space GO:0005615 9.73 CAT CCL2 CP CXCL8 FASLG FN1
3 membrane raft GO:0045121 9.71 CASP8 FAS FASLG TNF
4 secretory granule GO:0030141 9.65 IL1B SOD1 TGFB1
5 platelet alpha granule lumen GO:0031093 9.54 FN1 SERPINA1 TGFB1
6 extracellular region GO:0005576 9.47 CAT CCL2 CP CXCL8 FAS FASLG
7 blood microparticle GO:0072562 9.46 CP FN1 HSPA1L TGFB1
8 death-inducing signaling complex GO:0031264 9.32 CASP8 FAS
9 CD95 death-inducing signaling complex GO:0031265 9.26 CASP8 FAS
10 extracellular exosome GO:0070062 10.06 CAT CP FAS FASLG FN1 IL1B

Biological processes related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.99 CP FN1 IL6 SERPINA1
2 leukocyte migration GO:0050900 9.99 FN1 IL1B TGFB1 TNF
3 positive regulation of protein phosphorylation GO:0001934 9.97 FAS IL1B TGFB1 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 CASP8 FASLG IL1B TNF
5 inflammatory response GO:0006954 9.95 CCL2 CXCL8 IL1B IL6 NLRP3 TGFB1
6 platelet degranulation GO:0002576 9.91 FN1 SERPINA1 SOD1 TGFB1
7 defense response to Gram-positive bacterium GO:0050830 9.9 IL6 NLRP3 TNF
8 response to organic substance GO:0010033 9.9 SOD1 TGFB1 TNF
9 neutrophil chemotaxis GO:0030593 9.89 CCL2 CXCL8 IL1B
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.89 IL6 TGFB1 TNF
11 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 CCL2 TGFB1 TNF
12 cellular response to mechanical stimulus GO:0071260 9.88 CASP8 FAS IL1B TGFB1
13 positive regulation of interleukin-6 production GO:0032755 9.86 IL1B IL6 TNF
14 humoral immune response GO:0006959 9.86 CCL2 IL6 TNF
15 apoptotic signaling pathway GO:0097190 9.85 CASP8 FAS FASLG TNF
16 negative regulation of fat cell differentiation GO:0045599 9.83 IL6 TGFB1 TNF
17 positive regulation of cell division GO:0051781 9.82 CAT IL1B TGFB1
18 acute-phase response GO:0006953 9.81 FN1 IL6 SERPINA1
19 protein kinase B signaling GO:0043491 9.81 CCL2 IL1B TGFB1 TNF
20 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.79 CASP8 FAS FASLG
21 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.78 CASP8 FASLG TNF
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 CCL2 IL1B TGFB1 TNF
23 response to ethanol GO:0045471 9.77 CASP8 CAT SOD1
24 response to estradiol GO:0032355 9.77 CASP8 CAT TGFB1
25 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.77 CASP8 FAS FASLG NLRP3 TNF
26 negative regulation of neurogenesis GO:0050768 9.76 IL1B IL6 TNF
27 positive regulation of glial cell proliferation GO:0060252 9.74 IL1B IL6 TNF
28 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.73 CASP8 FAS FASLG
29 cellular response to lipopolysaccharide GO:0071222 9.73 CCL2 CXCL8 IL1B IL6 NLRP3 TNF
30 wound healing GO:0042060 9.72 FN1 TGFB1
31 PERK-mediated unfolded protein response GO:0036499 9.72 CCL2 CXCL8
32 response to reactive oxygen species GO:0000302 9.72 CAT SOD1
33 cellular response to organic cyclic compound GO:0071407 9.72 CASP8 CCL2 IL1B TGFB1 TNF
34 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
35 death-inducing signaling complex assembly GO:0071550 9.7 CASP8 TNF
36 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
37 response to glucocorticoid GO:0051384 9.7 IL6 TNF
38 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
39 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.68 IL6 NLRP3
40 interleukin-1 beta production GO:0032611 9.67 IL1B NLRP3
41 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
42 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 IL1B TNF
44 necroptotic signaling pathway GO:0097527 9.63 FAS FASLG TNF
45 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.63 CAT IL1B IL6 NLRP3 TGFB1 TNF
46 positive regulation of mononuclear cell migration GO:0071677 9.62 TGFB1 TNF
47 positive regulation of neuroinflammatory response GO:0150078 9.61 IL1B IL6 TNF
48 response to L-ascorbic acid GO:0033591 9.36 CAT
49 response to ozone GO:0010193 9.35 CAT
50 extrinsic apoptotic signaling pathway GO:0097191 9.35 CASP8 FAS FASLG TGFB1 TNF

Molecular functions related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.65 CAT FN1 GSTM1 SOD1 TGFB1
2 identical protein binding GO:0042802 9.61 CASP8 CAT FAS FN1 NLRP3 SERPINA1
3 chaperone binding GO:0051087 9.54 CP FN1 SOD1
4 protease binding GO:0002020 9.5 FN1 SERPINA1 TNF
5 tumor necrosis factor receptor binding GO:0005164 9.33 CASP8 FASLG TNF
6 cytokine activity GO:0005125 9.17 CCL2 CXCL8 FASLG IL1B IL6 TGFB1

Sources for Pneumoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
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63 PubMed
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70 SNOMED-CT via HPO
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72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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