MCID: PNM006
MIFTS: 50

Pneumoconiosis

Categories: Respiratory diseases

Aliases & Classifications for Pneumoconiosis

MalaCards integrated aliases for Pneumoconiosis:

Name: Pneumoconiosis 12 76 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10316
ICD10 33 J64
ICD9CM 35 505
MeSH 44 D011009
NCIt 50 C26861
SNOMED-CT 68 40122008
UMLS 73 C0032273

Summaries for Pneumoconiosis

Disease Ontology : 12 An interstitial lung disease that is caused by the inhalation of dust.

MalaCards based summary : Pneumoconiosis is related to anthracosis and silicosis. An important gene associated with Pneumoconiosis is H19 (H19, Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Iron and Trace Elements have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Pneumoconiosis is an occupational lung disease and a restrictive lung disease caused by the inhalation... more...

Related Diseases for Pneumoconiosis

Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 307)
# Related Disease Score Top Affiliating Genes
1 anthracosis 33.7 CCL2 SOD1 TNF
2 silicosis 32.6 TNF TGFB1 NLRP3 IL1B FASLG FAS
3 asbestosis 32.4 GSTM1 IL6 SERPINA1
4 bronchitis 30.7 CXCL8 SERPINA1 TNF
5 arteries, anomalies of 30.4 CCL2 IL1B IL6 TNF
6 pulmonary fibrosis 30.2 CCL2 IL1B MUC5B TGFB1
7 arthritis 30.2 CCL2 TNF TGFB1 IL6 IL1B CXCL8
8 endocarditis 30.1 CXCL8 IL6 TNF
9 peptic ulcer disease 29.9 CXCL8 IL1B TNF
10 respiratory failure 29.9 TNF SERPINA1 CXCL8
11 heart disease 29.9 TNF IL6 IL1B H19 CXCL8
12 rheumatoid arthritis 29.8 TNF TGFB1 IL6 IL1B H19 CXCL8
13 pneumonia 29.8 TNF MUC5B IL6 IL1B CXCL8 CCL2
14 pulmonary disease, chronic obstructive 29.7 TNF TGFB1 SERPINA1 IL6 GSTM1 CXCL8
15 lung disease 29.5 TNF TGFB1 SERPINA1 MUC5B IL6 IL1B
16 pulmonary fibrosis, idiopathic 29.4 TNF TGFB1 MUC5B IL1B FASLG CXCL8
17 kaolin pneumoconiosis 12.4
18 pneumoconiosis due to talc 12.4
19 graphite pneumoconiosis 12.2
20 mixed mineral dust pneumoconiosis 12.1
21 slate pneumoconiosis 12.0
22 caplan's syndrome 11.9
23 labrador lung 11.9
24 silicosiderosis 11.6
25 baritosis 11.5
26 berylliosis 11.5
27 siderosis 11.3
28 aluminosis 11.3
29 shaver's disease 11.1
30 nontuberculous mycobacterial lung disease 11.0
31 asbestos intoxication 10.6
32 anthracosilicosis 10.5
33 lung cancer 10.5
34 critical limb ischemia 10.4 TNF IL6
35 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
36 juvenile ankylosing spondylitis 10.4 TNF IL6
37 staphylococcal toxic shock syndrome 10.4 TNF IL1B
38 leukomalacia 10.3 TNF IL6
39 periodontitis, chronic 10.3 IL6 IL1B
40 scorpion envenomation 10.3 IL6 TNF
41 cardiogenic shock 10.3 TNF IL6
42 paraneoplastic syndromes 10.3 IL6 IL1B
43 burn scar 10.3 TGFB1 FAS
44 toxic optic neuropathy 10.3 IL1B CAT
45 retinitis pigmentosa 73 10.3 IL1B CCL2
46 purulent labyrinthitis 10.3 IL1B CCL2
47 tungiasis 10.3 TNF CXCL8
48 leukoregulin 10.3 TGFB1 CXCL8
49 chronic venous leg ulcers 10.3 FASLG FAS
50 lymphocytic gastritis 10.3 FASLG FAS

Comorbidity relations with Pneumoconiosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Chronic Myocardial Ischemia Familial Atrial Fibrillation
Heart Disease Ischemic Heart Disease
Postinflammatory Pulmonary Fibrosis Prostatic Hypertrophy
Respiratory Failure

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to Pneumoconiosis

Symptoms & Phenotypes for Pneumoconiosis

GenomeRNAi Phenotypes related to Pneumoconiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 CASP8 CXCL8 FAS IL1B NLRP3 SOD1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 CASP8 CXCL8 FAS IL1B NLRP3 SOD1
3 Reduced mammosphere formation GR00396-S 9.56 CCL2 CXCL8 FAS FASLG GSTM1 H19

MGI Mouse Phenotypes related to Pneumoconiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 CASP8 CAT CP FAS FASLG IL6
2 homeostasis/metabolism MP:0005376 10.18 CASP8 CAT CP FAS FASLG IL1B
3 hematopoietic system MP:0005397 10.17 CASP8 CP FAS FASLG IL1B IL6
4 immune system MP:0005387 10.15 CASP8 CCL2 CP FAS FASLG IL1B
5 cardiovascular system MP:0005385 10.13 CASP8 CP FAS FASLG IL1B IL6
6 integument MP:0010771 9.97 CASP8 FAS FASLG IL1B IL6 NLRP3
7 liver/biliary system MP:0005370 9.91 CASP8 CP FAS FASLG IL6 NLRP3
8 neoplasm MP:0002006 9.81 CASP8 CAT FAS FASLG IL1B IL6
9 nervous system MP:0003631 9.65 CASP8 CP FAS FASLG IL1B IL6
10 respiratory system MP:0005388 9.17 CASP8 FAS FASLG IL6 MUC5B TGFB1

Drugs & Therapeutics for Pneumoconiosis

Drugs for Pneumoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2 Trace Elements Phase 4
3 Micronutrients Phase 4
4 Liver Extracts Phase 4
5
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
6
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
7
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
8
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
9
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
10 Sympatholytics Phase 2, Phase 3
11 Vasodilator Agents Phase 2, Phase 3
12 Antihypertensive Agents Phase 2, Phase 3
13 Anti-Arrhythmia Agents Phase 2, Phase 3
14 Neurotransmitter Agents Phase 2, Phase 3
15 Adrenergic Antagonists Phase 2, Phase 3
16 Adrenergic Agents Phase 2, Phase 3
17 Calcium, Dietary Phase 2, Phase 3
18 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
19 Autonomic Agents Phase 2, Phase 3
20 Adrenergic beta-Antagonists Phase 2, Phase 3
21 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
22 calcium channel blockers Phase 2, Phase 3
23 Antitubercular Agents Phase 3
24 Nucleic Acid Synthesis Inhibitors Phase 3
25 Antibiotics, Antitubercular Phase 3
26 Cytochrome P-450 CYP3A Inducers Phase 3
27 Lipid Regulating Agents Phase 3
28 Antimetabolites Phase 3
29 Anti-Infective Agents Phase 3
30 Hypolipidemic Agents Phase 3
31 Anti-Bacterial Agents Phase 3
32 Immunologic Factors Phase 3
33 Vaccines Phase 3
34
Infliximab Approved Phase 1, Phase 2 170277-31-3
35 Mitogens Phase 1, Phase 2
36 Mesalamine Phase 1, Phase 2 89-57-6
37 Analgesics Phase 1, Phase 2
38 Analgesics, Non-Narcotic Phase 1, Phase 2
39 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
40 Anti-Inflammatory Agents Phase 1, Phase 2
41 Antirheumatic Agents Phase 1, Phase 2,Phase 2
42 Dermatologic Agents Phase 1, Phase 2
43 Gastrointestinal Agents Phase 1, Phase 2
44
Heparin Approved, Investigational 9005-49-6 772 46507594
45
Deferiprone Approved 30652-11-0 2972
46 Pharmaceutical Solutions
47 calcium heparin
48 Respiratory System Agents
49 Iron Chelating Agents
50 Chelating Agents

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome Unknown status NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
3 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Unknown status NCT02430259 Phase 3 Weekly INH / RRT given by DOT
4 Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older Completed NCT00753272 Phase 3
5 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
6 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
7 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
8 Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Unknown status NCT02790762 Phase 1
9 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
10 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Active, not recruiting NCT02668068 Phase 1
11 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Unknown status NCT02596347
12 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343
13 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
14 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
15 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
16 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
17 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
18 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
19 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Completed NCT01284127
20 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
21 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
22 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
23 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
24 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693
25 Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. Recruiting NCT03464344 Not Applicable
26 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
27 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6

Search NIH Clinical Center for Pneumoconiosis

Cochrane evidence based reviews: pneumoconiosis

Genetic Tests for Pneumoconiosis

Anatomical Context for Pneumoconiosis

MalaCards organs/tissues related to Pneumoconiosis:

41
Lung, Testes, Heart, Liver, Monocytes, Skin, Bone

Publications for Pneumoconiosis

Articles related to Pneumoconiosis:

(show top 50) (show all 1067)
# Title Authors Year
1
Estimated economic costs of coal workers' pneumoconiosis among coal workers redeployed from the Fuxin mining group in China. ( 29116190 )
2018
2
Assessment of physicians' proficiency in reading chest radiographs for pneumoconiosis, based on a 60-film examination set with two factors constituting eight indices. ( 29806618 )
2018
3
TNFR/TNF-I+ signaling pathway regulates apoptosis of alveolar macrophages in coal workers' pneumoconiosis. ( 29416696 )
2018
4
Association analysis identifies new risk loci for coal workers' pneumoconiosis in Han Chinese men. ( 29394417 )
2018
5
Mica pneumoconiosis: a neglected occupational lung disease. ( 29759917 )
2018
6
Both-sided native valve infective endocarditis in a drug addict with incidental pneumoconiosis. ( 29704724 )
2018
7
Should hut lung be called domestically acquired particulate lung disease or domestically acquired pneumoconiosis? ( 29487788 )
2018
8
Prevalence of latent tuberculosis infection among coal workers' pneumoconiosis patients in China: a cross-sectional study. ( 29642880 )
2018
9
Establishment and application of an index system for prevention of coal workers' pneumoconiosis: a Delphi and analytic hierarchy process study in four state-owned coal enterprises of China. ( 29563194 )
2018
10
Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269. ( 29415464 )
2018
11
Prevalence and characteristics of COPD among pneumoconiosis patients at an occupational disease prevention institute: a cross-sectional study. ( 29378587 )
2018
12
Dental Technicians' Pneumoconiosis; Illness Behind a Healthy Smile - Case Series of a Reference Center in Turkey. ( 29743783 )
2018
13
WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis. ( 29958118 )
2018
14
A response to the Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269 by the Author Mei Yong. ( 29438277 )
2018
15
Continued increase in lung transplantation for coal workers' pneumoconiosis in the United States. ( 29732582 )
2018
16
Pneumoconiosis in a polytetrafluoroethylene (PTFE) spray worker: a case report with an occupational hygiene study. ( 29992029 )
2018
17
Continued Increase in Prevalence of Coal Workers' Pneumoconiosis in the United States, 1970-2017. ( 30024799 )
2018
18
Coal Workers' Pneumoconiosis-Attributable Years of Potential Life Lost to Life Expectancy and Potential Life Lost Before Age 65 Years - United States, 1999-2016. ( 30070982 )
2018
19
Upregulated has-miR-4516 as a potential biomarker for early diagnosis of dust-induced pulmonary fibrosis in patients with pneumoconiosis. ( 30090591 )
2018
20
Outcomes of community-based and home-based pulmonary rehabilitation for pneumoconiosis patients: a retrospective study. ( 30092783 )
2018
21
Time trends and future prediction of coal worker's pneumoconiosis in opencast coal mine in China based on the APC model. ( 30107832 )
2018
22
A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis. ( 30128271 )
2018
23
Association between tumor necrosis factor-α -308 Gauss/A polymorphism and risk of silicosis and coal workers pneumoconiosis in Chinese population. ( 30257124 )
2018
24
Computed tomography findings of arc-welders' pneumoconiosis: Comparison with silicosis. ( 30292280 )
2018
25
Extracellular histones promote pulmonary fibrosis in patients with coal workers' pneumoconiosis. ( 30308624 )
2018
26
Comparison of the International Classification of High-resolution Computed Tomography for Occupational and Environmental Respiratory Diseases with the International Labor Organization International Classification of Radiographs of Pneumoconiosis. ( 30344228 )
2018
27
Mixed-dust pneumoconiosis: Review of diagnostic and classification problems with presentation of a work-related case. ( 30368172 )
2018
28
TNF-α-TNFR signal pathway inhibits autophagy and promotes apoptosis of alveolar macrophages in coal worker's pneumoconiosis. ( 30467847 )
2018
29
Daytime blood pressure surges following hypoxic episodes in a case of pneumoconiosis with lacunar stroke recurrences. ( 28263202 )
2017
30
Increasing Severity of Pneumoconiosis Among Younger Former US Coal Miners Working Exclusively Under Modern Dust-Control Regulations. ( 28598937 )
2017
31
TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis. ( 28698801 )
2017
32
Progressive massive fibrosis in patients with pneumoconiosis: utility of MRI in differentiating from lung cancer. ( 28361545 )
2017
33
Element-based prognostics of occupational pneumoconiosis using micro-proton-induced X-ray emission analysis. ( 28912379 )
2017
34
Squamous cell carcinoma of the lung showing a ground glass nodule on high-resolution computed tomography associated with pneumoconiosis: a case report. ( 28963659 )
2017
35
Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. ( 28272360 )
2017
36
LRBA Gene Polymorphisms and Risk of Coal Workers' Pneumoconiosis: A Case-Control Study from China. ( 28953250 )
2017
37
The association of LAMB1 polymorphism and expression changes with the risk of coal workers' pneumoconiosis. ( 28444932 )
2017
38
Survival Analysis of Coal Workers' Pneumoconiosis (CWP) Patients in a State-Owned Mine in the East of China from 1963 to 2014. ( 28481235 )
2017
39
Polymorphisms in autophagy related genes and the coal workers' pneumoconiosis in a Chinese population. ( 28844669 )
2017
40
Loss of regulatory characteristics in CD4(+) CD25(+/hi) T cells induced by impaired transforming growth factor beta secretion in pneumoconiosis. ( 28913840 )
2017
41
A case of mixed dust pneumoconiosis with desquamative interstitial pneumonia-like reaction in an aluminum welder. ( 28239542 )
2017
42
Association between Genetic Variants of Transforming Growth Factor-I^1 and Susceptibility of Pneumoconiosis: A Meta-analysis. ( 28139521 )
2017
43
Wood charcoal dust pneumoconiosis. ( 28365221 )
2017
44
Cross-section analysis of coal workers' pneumoconiosis and higher brachial-ankle pulse wave velocity within Kailuan study. ( 28148238 )
2017
45
Coal miner participation in a job transfer program designed to prevent progression of pneumoconiosis, United States, 1986-2016. ( 29116886 )
2017
46
Evaluation of dental technician's pneumoconiosis using chest X-rayand HRCT: correlation between radiological and functional findings. ( 28263498 )
2017
47
[Clinical observation of external diaphragm pacing in patients with pneumoconiosis complicated with chronic obstructive pulmonary disease in stable stage]. ( 28614935 )
2017
48
Dental Technicians' Pneumoconiosis. ( 29021460 )
2017
49
Diagnostic and clinical application value of magnetic resonance imaging (MRI) for progressive massive fibrosis of coal worker pneumoconiosis: Case reports. ( 28514304 )
2017
50
Computerized Classification of Pneumoconiosis on Digital Chest Radiography Artificial Neural Network with Three Stages. ( 28108817 )
2017

Variations for Pneumoconiosis

Expression for Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for Pneumoconiosis

Pathways related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 CASP8 CAT CCL2 CXCL8 FASLG IL1B
2
Show member pathways
13.73 CASP8 CCL2 CXCL8 FAS FASLG IL1B
3
Show member pathways
13.6 CASP8 CXCL8 FAS FASLG IL1B IL6
4
Show member pathways
13.46 CCL2 CXCL8 FAS FASLG IL1B IL6
5
Show member pathways
13.4 CCL2 CXCL8 FASLG IL1B IL6 TGFB1
6
Show member pathways
13.35 CASP8 CCL2 CXCL8 FAS FASLG IL1B
7
Show member pathways
13.09 CASP8 CCL2 CXCL8 FAS FASLG IL1B
8
Show member pathways
13 CASP8 CCL2 FAS FASLG IL6 TNF
9
Show member pathways
12.92 CASP8 CCL2 CXCL8 FAS FASLG IL1B
10 12.9 CASP8 CXCL8 FAS FASLG GSTM1 IL6
11
Show member pathways
12.9 CASP8 CXCL8 FAS FASLG HSPA1L IL1B
12 12.83 CASP8 FAS FASLG HSPA1L IL1B TGFB1
13
Show member pathways
12.81 CASP8 CXCL8 IL1B IL6 TNF
14
Show member pathways
12.73 CASP8 FAS FASLG IL1B TNF
15
Show member pathways
12.67 CASP8 FAS FASLG IL1B TNF
16 12.63 CCL2 FAS FASLG IL1B TNF
17
Show member pathways
12.52 CASP8 FAS FASLG TNF
18
Show member pathways
12.49 FAS IL1B IL6 TGFB1 TNF
19
Show member pathways
12.42 CAT CCL2 IL1B IL6 SOD1 TNF
20
Show member pathways
12.38 CASP8 FAS FASLG TNF
21
Show member pathways
12.35 CXCL8 IL1B IL6 TNF
22 12.35 CASP8 FAS IL6 TNF
23 12.35 FAS FASLG TGFB1 TNF
24
Show member pathways
12.35 CASP8 CCL2 CXCL8 IL1B IL6 MUC5B
25
Show member pathways
12.34 CASP8 HSPA1L IL1B TGFB1 TNF
26
Show member pathways
12.34 CASP8 CCL2 CXCL8 FAS FASLG HSPA1L
27
Show member pathways
12.33 CXCL8 IL1B IL6 TGFB1 TNF
28
Show member pathways
12.31 CASP8 FAS FASLG TNF
29 12.31 CASP8 IL1B IL6 TGFB1 TNF
30
Show member pathways
12.31 CP CXCL8 IL1B IL6 MUC5B TNF
31 12.3 CASP8 FAS FASLG TNF
32
Show member pathways
12.29 CASP8 IL1B IL6 NLRP3 TNF
33
Show member pathways
12.29 CASP8 FAS FASLG IL1B NLRP3 TNF
34
Show member pathways
12.25 CXCL8 FAS FASLG IL1B IL6 TNF
35 12.24 CXCL8 IL1B IL6 TNF
36 12.16 CCL2 GSTM1 IL1B TNF
37
Show member pathways
12.16 CAT FASLG IL6 TGFB1
38
Show member pathways
12.14 CCL2 CXCL8 IL1B IL6 TGFB1
39 12.13 FAS IL6 TGFB1 TNF
40
Show member pathways
12.12 IL1B IL6 TGFB1 TNF
41
Show member pathways
12.1 IL1B IL6 SOD1 TNF
42 12.08 CCL2 CXCL8 IL1B IL6 TGFB1 TNF
43 12.01 CXCL8 IL1B IL6 TGFB1
44 12.01 CASP8 CCL2 FAS IL1B IL6 TNF
45 12 CXCL8 IL1B IL6 TGFB1 TNF
46 11.93 CCL2 CXCL8 IL1B IL6 TGFB1 TNF
47 11.92 IL1B IL6 TNF
48 11.91 CXCL8 IL1B TNF
49
Show member pathways
11.9 CXCL8 IL6 TGFB1
50 11.87 CXCL8 IL1B IL6

GO Terms for Pneumoconiosis

Cellular components related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 CAT CP FAS FASLG IL1B MUC5B
2 extracellular space GO:0005615 9.73 CAT CCL2 CP CXCL8 FASLG IL1B
3 membrane raft GO:0045121 9.62 CASP8 FAS FASLG TNF
4 secretory granule GO:0030141 9.58 IL1B SOD1 TGFB1
5 extracellular region GO:0005576 9.47 CAT CCL2 CP CXCL8 FAS FASLG
6 death-inducing signaling complex GO:0031264 9.26 CASP8 FAS
7 CD95 death-inducing signaling complex GO:0031265 9.16 CASP8 FAS

Biological processes related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.99 CCL2 IL1B TGFB1 TNF
2 positive regulation of protein phosphorylation GO:0001934 9.97 FAS IL1B TGFB1 TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 CASP8 FASLG IL1B TNF
4 inflammatory response GO:0006954 9.95 CCL2 CXCL8 IL1B IL6 NLRP3 TGFB1
5 response to ethanol GO:0045471 9.9 CASP8 CAT IL1B SOD1
6 defense response to Gram-positive bacterium GO:0050830 9.89 IL6 NLRP3 TNF
7 response to estradiol GO:0032355 9.89 CASP8 CAT IL1B TGFB1
8 response to organic substance GO:0010033 9.88 SOD1 TGFB1 TNF
9 neutrophil chemotaxis GO:0030593 9.88 CCL2 CXCL8 IL1B
10 cellular response to mechanical stimulus GO:0071260 9.88 CASP8 FAS IL1B TGFB1
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.87 IL6 TGFB1 TNF
12 response to glucocorticoid GO:0051384 9.86 IL1B IL6 TNF
13 positive regulation of interleukin-6 production GO:0032755 9.85 IL1B IL6 TNF
14 humoral immune response GO:0006959 9.85 CCL2 IL6 TNF
15 apoptotic signaling pathway GO:0097190 9.85 CASP8 FAS FASLG TNF
16 negative regulation of fat cell differentiation GO:0045599 9.82 IL6 TGFB1 TNF
17 positive regulation of cell division GO:0051781 9.81 CAT IL1B TGFB1
18 protein kinase B signaling GO:0043491 9.8 CCL2 IL1B TGFB1 TNF
19 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.79 CASP8 FAS FASLG
20 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.78 CASP8 FASLG TNF
21 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.77 CASP8 FAS FASLG NLRP3 TNF
22 negative regulation of neurogenesis GO:0050768 9.76 IL1B IL6 TNF
23 positive regulation of glial cell proliferation GO:0060252 9.74 IL1B IL6 TNF
24 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.73 CASP8 FAS FASLG
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 CCL2 IL1B TGFB1 TNF
26 cellular response to lipopolysaccharide GO:0071222 9.73 CCL2 CXCL8 IL1B IL6 NLRP3 TNF
27 cellular response to organic cyclic compound GO:0071407 9.72 CASP8 CCL2 IL1B TGFB1 TNF
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
29 PERK-mediated unfolded protein response GO:0036499 9.71 CCL2 CXCL8
30 response to reactive oxygen species GO:0000302 9.7 CAT SOD1
31 cytokine-mediated signaling pathway GO:0019221 9.7 CCL2 CXCL8 FASLG IL1B IL6 TGFB1
32 negative regulation of lipid storage GO:0010888 9.69 IL6 TNF
33 death-inducing signaling complex assembly GO:0071550 9.69 CASP8 TNF
34 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
35 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
36 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.67 IL6 NLRP3
37 interleukin-1 beta production GO:0032611 9.66 IL1B NLRP3
38 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
39 response to L-ascorbic acid GO:0033591 9.65 CAT IL1B
40 response to ozone GO:0010193 9.65 CAT IL1B
41 necroptotic signaling pathway GO:0097527 9.65 FAS FASLG TNF
42 chronic inflammatory response to antigenic stimulus GO:0002439 9.63 IL1B TNF
43 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
44 positive regulation of neuroinflammatory response GO:0150078 9.63 IL1B IL6 TNF
45 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IL1B TNF
46 positive regulation of mononuclear cell migration GO:0071677 9.62 TGFB1 TNF
47 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 CAT IL1B IL6 NLRP3 TGFB1 TNF
48 extrinsic apoptotic signaling pathway GO:0097191 9.02 CASP8 FAS FASLG TGFB1 TNF
49 immune response GO:0006955 10.07 CCL2 CXCL8 FAS FASLG IL1B IL6
50 regulation of signaling receptor activity GO:0010469 10.05 CCL2 CXCL8 FASLG IL1B IL6 TGFB1

Molecular functions related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.56 CASP8 CAT FAS NLRP3 SERPINA1 SOD1
2 tumor necrosis factor receptor binding GO:0005164 9.33 CASP8 FASLG TNF
3 death receptor binding GO:0005123 9.26 CASP8 FASLG
4 cytokine activity GO:0005125 9.17 CCL2 CXCL8 FASLG IL1B IL6 TGFB1

Sources for Pneumoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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