MCID: PNM006
MIFTS: 55

Pneumoconiosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Pneumoconiosis

MalaCards integrated aliases for Pneumoconiosis:

Name: Pneumoconiosis 12 74 58 54 43 15 71

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:10316
ICD9CM 34 505
MeSH 43 D011009
NCIt 49 C26861
SNOMED-CT 67 40122008
MESH via Orphanet 44 D011009
UMLS via Orphanet 72 C0032273
Orphanet 58 ORPHA182098
UMLS 71 C0032273

Summaries for Pneumoconiosis

Disease Ontology : 12 An interstitial lung disease that is caused by the inhalation of dust.

MalaCards based summary : Pneumoconiosis is related to anthracosis and asbestosis. An important gene associated with Pneumoconiosis is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Amlodipine and Metoprolol have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Pneumoconiosis is the general term for a class of interstitial lung diseases where inhalation of dust... more...

Related Diseases for Pneumoconiosis

Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 676)
# Related Disease Score Top Affiliating Genes
1 anthracosis 34.5 TNF TGFB1 NLRP3 IL6 CCL2
2 asbestosis 33.0 SERPINA1 NLRP3 IL6 GSTM1 CAT
3 silicosis 32.6 TNF TGFB1 NLRP3 IL4 IL1RN IL1B
4 anthracosilicosis 32.1 IL1B CP
5 pulmonary fibrosis 31.8 TGFB1 IL1B CXCL8 CCL2
6 idiopathic interstitial pneumonia 31.3 TGFB1 IL4 FN1 CXCL8 CCL2
7 pulmonary tuberculosis 31.1 TNF IL6 IL4 IL10 CCL2 CAT
8 sarcoidosis 1 31.1 TNF IL1RN IL1B CCL2
9 mycobacterium tuberculosis 1 31.0 TNF IL4 IL10 FN1
10 pleural disease 30.9 TNF IL6 IL1B CXCL8
11 bronchitis 30.9 TNF SERPINA1 IL6 IL4 IL1B IL10
12 rheumatic disease 30.8 TNF IL1RN IL1B IL10
13 systemic scleroderma 30.8 TNF TGFB1 IL6 IL4
14 pulmonary alveolar proteinosis 30.7 TNF IL6 IL10 CXCL8 CCL2
15 bronchiectasis 30.7 TNF SERPINA1 IL6 CXCL8
16 haemophilus influenzae 30.7 TNF CXCL8
17 pleural tuberculosis 30.6 TNF CXCL8 CCL2
18 pleurisy 30.6 TNF TGFB1 IL1RN CXCL8 CCL2
19 aspergillosis 30.5 TNF IL6 IL4 IL1RN IL1B IL10
20 echinococcosis 30.5 TNF IL6 IL10
21 mycobacterium kansasii 30.5 NLRP3 FN1 CXCL8
22 interstitial lung disease 30.5 TNF TGFB1 IL6 IL4 IL1B IL10
23 cellulitis 30.4 TNF IL6 IL10
24 pulmonary edema 30.4 TNF IL1B IL10 FASLG CXCL8
25 respiratory failure 30.4 TNF SOD1 SERPINA1 IL6 IL1RN IL1B
26 bronchopneumonia 30.4 TNF IL6 IL10 CXCL8
27 pericarditis 30.4 TNF IL6 IL1RN IL1B CXCL8
28 bronchiolitis obliterans 30.4 TNF IL6 IL10 CXCL8
29 vasculitis 30.4 TNF SERPINA1 IL6 CCL2
30 coronary artery anomaly 30.3 TNF IL6 IL1RN IL1B IL10 CXCL8
31 cryptococcosis 30.3 TNF IL4 IL10
32 gout 30.3 TNF NLRP3 IL6 IL1B CXCL8
33 peptic ulcer disease 30.3 TNF IL1RN IL1B IL10 CXCL8 CAT
34 lung disease 30.3 TNF TGFB1 SOD1 SERPINA1 IL6 IL4
35 pulmonary eosinophilia 30.3 SERPINA1 IL4 CXCL8
36 pulmonary hypertension 30.2 TNF SPP1 IL6 IL1B FN1 CXCL8
37 extrinsic allergic alveolitis 30.2 SOD1 IL6 IL1B IL10 FN1 CXCL8
38 endocarditis 30.2 TNF IL6 IL10 CXCL8 CAT
39 severe acute respiratory syndrome 30.2 TNF IL6 IL10 CXCL8 CCL2
40 paranasal sinus disease 30.1 TNF TGFB1 IL4 IL10 CXCL8
41 sleep apnea 30.1 TNF IL6 IL1B IL10 CXCL8 CCL2
42 pulmonary disease, chronic obstructive 30.1 TNF TGFB1 SERPINA1 IL6 IL4 IL1B
43 allergic hypersensitivity disease 30.0 TNF IL4 IL10 CXCL8
44 arthritis 30.0 TNF TGFB1 IL6 IL4 IL1RN IL1B
45 collagen disease 30.0 TNF IL6 IL4 IL10 FN1
46 bronchiolitis 29.9 TNF IL6 IL4 IL10 CXCL8 CCL2
47 bacterial infectious disease 29.9 TNF IL6 IL1RN IL1B IL10 CXCL8
48 myelodysplastic syndrome 29.9 TNF IL6 IL1B IL10 GSTM1 FASLG
49 esophagitis 29.8 TNF TGFB1 IL6 IL4 IL1B IL10
50 tonsillitis 29.8 TNF SOD1 IL6 IL4 IL1B IL10

Comorbidity relations with Pneumoconiosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Familial Atrial Fibrillation Heart Disease
Postinflammatory Pulmonary Fibrosis Prostatic Hypertrophy
Respiratory Failure

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to Pneumoconiosis

Symptoms & Phenotypes for Pneumoconiosis

GenomeRNAi Phenotypes related to Pneumoconiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 CASP8 CXCL8 IL10 IL1B NLRP3 SOD1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 CASP8 CXCL8 IL10 IL1B NLRP3 SOD1

MGI Mouse Phenotypes related to Pneumoconiosis:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.39 CASP8 CAT CP FASLG FN1 IL10
2 homeostasis/metabolism MP:0005376 10.39 CASP8 CAT CP FASLG FN1 IL10
3 hematopoietic system MP:0005397 10.37 CASP8 CP FASLG FN1 IL10 IL1B
4 immune system MP:0005387 10.37 CASP8 CCL2 CP FASLG FN1 IL10
5 cardiovascular system MP:0005385 10.34 CASP8 CP FASLG FN1 IL10 IL1B
6 integument MP:0010771 10.29 CASP8 FASLG FN1 IL10 IL1B IL1RN
7 mortality/aging MP:0010768 10.28 CASP8 CAT FASLG FN1 IL10 IL1B
8 liver/biliary system MP:0005370 10.23 CASP8 CP FASLG FN1 IL10 IL4
9 nervous system MP:0003631 10.13 CASP8 CP FASLG FN1 IL10 IL1B
10 neoplasm MP:0002006 10.11 CASP8 CAT FASLG FN1 IL10 IL1B
11 craniofacial MP:0005382 10.08 FN1 IL10 IL1B IL4 SPP1 TGFB1
12 muscle MP:0005369 10.01 CASP8 FN1 IL10 IL6 SOD1 SPP1
13 reproductive system MP:0005389 10 FASLG FN1 IL10 IL1RN IL4 IL6
14 respiratory system MP:0005388 9.76 CASP8 FASLG IL10 IL4 IL6 SPP1
15 skeleton MP:0005390 9.73 FASLG FN1 IL10 IL1B IL1RN IL4
16 vision/eye MP:0005391 9.28 CP FASLG IL10 IL4 IL6 SOD1

Drugs & Therapeutics for Pneumoconiosis

Drugs for Pneumoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
2
Metoprolol Approved, Investigational Phase 2, Phase 3 51384-51-1, 37350-58-6 4171
3
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
4 Antihypertensive Agents Phase 2, Phase 3
5 Neurotransmitter Agents Phase 2, Phase 3
6 Anti-Arrhythmia Agents Phase 2, Phase 3
7 Adrenergic Antagonists Phase 2, Phase 3
8 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
9 Adrenergic beta-Antagonists Phase 2, Phase 3
10 Vasodilator Agents Phase 2, Phase 3
11 Autonomic Agents Phase 2, Phase 3
12 calcium channel blockers Phase 2, Phase 3
13 Calcium, Dietary Phase 2, Phase 3
14 Sympatholytics Phase 2, Phase 3
15 Adrenergic Agents Phase 2, Phase 3
16 Hormones Phase 2, Phase 3
17
Nintedanib Approved Phase 2 656247-17-5 56843413
18
Cocaine Approved, Illicit 50-36-2 5760 446220

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Study Was Approved by the Ethics Committee of Our Institution, Which is Accredited by the Office of Human Research Protection as an Institutional Review Board Unknown status NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
2 The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial Not yet recruiting NCT04161014 Phase 2 Nintedanib 150 MG [Ofev]
3 A Phase I Study of Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Unknown status NCT02790762 Phase 1
4 A Multicenter, Randomized, Single-blind, Parallel-group Study of Combined Large Volume WLL With Clinical Grade Umbilical Cord Mesenchymal Stem Cells(MSC) Transplantation for Treatment of Pneumoconiosis Completed NCT02668068 Phase 1
5 Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed in Patients With Emphysema and Interstitial Fibrosis Compared to Non-diseased Areas Unknown status NCT02705144
6 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
7 Palliative Care Coaching for Family Caregivers & Patients With Rare Advanced Lung Disease Completed NCT03813667
8 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
9 The Experience of Patients and Family Caregivers in Managing Pneumoconiosis in the Family Context: An Exploratory Qualitative Study Recruiting NCT04022902
10 Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma Enrolling by invitation NCT04205708

Search NIH Clinical Center for Pneumoconiosis

Cochrane evidence based reviews: pneumoconiosis

Genetic Tests for Pneumoconiosis

Anatomical Context for Pneumoconiosis

MalaCards organs/tissues related to Pneumoconiosis:

40
Lung, Heart, Bone, Testes, Liver, Thyroid, Lymph Node

Publications for Pneumoconiosis

Articles related to Pneumoconiosis:

(show top 50) (show all 4084)
# Title Authors PMID Year
1
[Regulation role of superoxide dismutase coenzyme on Fas/FasL signal transduction and apoptosis in alveolar macrophages of pneumoconiosis patients]. 54 61
18727868 2008
2
[Activity of superoxide dismutase and level of lipid peroxidation in pneumoconiosis patients]. 54 61
17908436 2007
3
[Significance of serum sialic acid and ceruloplasmin in early lung fibrosis of pneumoconiosis]. 54 61
16600124 2006
4
[Free radial activity in patients with pneumoconioses]. 54 61
8629354 1996
5
Blood antioxidant enzymes as markers of exposure or effect in coal miners. 54 61
8563856 1996
6
Autophagy, an important therapeutic target for pulmonary fibrosis diseases. 61
31877297 2020
7
Editorial: Timely topical reviews on climate change, indoor air pollution, coalworkers' pneumoconiosis, and chronic obstructive pulmonary disease. 61
31904625 2020
8
Coal mining and lung disease in the 21st century. 61
31815751 2020
9
Respirable coal mine dust at surface mines, United States, 1982-2017. 61
31820465 2020
10
Assessment of silica dust exposure profile in relation to prevalence of silicosis among Indian sandstone mine workers: Need for review of standards. 61
31773774 2020
11
CT/NIRF dual-modal imaging tracking and therapeutic efficacy of transplanted mesenchymal stem cells labeled with Au nanoparticles in silica-induced pulmonary fibrosis. 61
32022096 2020
12
Pneumoconiosis Caused by Inhalation of Metallic Titanium Grindings. 61
31645530 2020
13
Domestic mixed-dust pneumoconiosis: A case report and literature review. 61
31890560 2020
14
Silica-related diseases in the modern world. 61
31989662 2020
15
Risk of atrial fibrillation in patients with pneumoconiosis: A nationwide study in Taiwan. 61
31785026 2020
16
The clinical value of F-18 FDG PET/CT in differentiating malignant from benign lesions in pneumoconiosis patients. 61
31338654 2020
17
A case of resected primary pulmonary pleomorphic carcinoma with long-term survival after multidisciplinary treatment. 61
31993853 2020
18
A woman and her breathtaking jewelry. 61
31960767 2020
19
[The application of holistic nursing in the rehabilitation of occupational pneumoconiosis complicated with chronic obstructive pulmonary disease]. 61
31937026 2019
20
[Clinical characteristics of pneumoconiosis complicated with chronic obstructive pulmonary disease]. 61
31937028 2019
21
Superior mediastinal lymphadenopathy by silicosis mimicking metastasis of papillary thyroid carcinoma - Case report and literature review. 61
31899060 2019
22
The experience of patients and family caregivers in managing pneumoconiosis in the family context: A study protocol. 61
31576609 2019
23
[Incidence and yrend of occupational pneumoconiosis in Ankang city from 1974 to 2017]. 61
31937033 2019
24
A thermogravimetric analysis application to determine coal, carbonate, and non-carbonate minerals mass fractions in respirable mine dust. 61
31868573 2019
25
[A study of social assistance for patients with occupational diseases]. 61
31937045 2019
26
[Analysis on the characteristics of new occupational diseases in Changzhou City from 2006 to 2018]. 61
31937042 2019
27
Integration of inflammation, fibrosis, and cancer induced by carbon nanotubes. 61
31537143 2019
28
[Nursing care of a patient with recurrent massive hemoptysis caused by coal worker's pneumoconiosis complicated by invasive pulmonary aspergillosis]. 61
31826559 2019
29
Submersion in Industrial Powders That Lead to Tracheal Impaction and an Unusual Intubation. 61
31604590 2019
30
[Correlation research between imaging performance and pulmonary function of pneumoconiosis patients at stage three]. 61
31826547 2019
31
[Exploration and application of occupational disease risk assessment model based on information diffusion theory]. 61
31826543 2019
32
Disseminated blastomycosis in coalworkers' pneumoconiosis. 61
31656442 2019
33
Application of endobronchial ultrasonography using a guide sheath and electromagnetic navigation bronchoscopy in the diagnosis of atypical bacteriologically-negative pulmonary tuberculosis. 61
31807548 2019
34
Targeting the RAS axis alleviates silicotic fibrosis and Ang II-induced myofibroblast differentiation via inhibition of the hedgehog signaling pathway. 61
31181250 2019
35
3D magnetopneumography magnetic dipole model and its application using fluxgate gradiometers. 61
31495923 2019
36
Atypical presentation of rheumatoid arthritis: a case of massive bilateral pleural effusions in a patient with Caplan syndrome. 61
31653636 2019
37
[Epidemiological study of occupational diseases in Gansu province, China in 2010-2017]. 61
31726514 2019
38
The Health Impact of Mineral Dust Air Pollution on the Global and Local Scale (on the example from Slovakia). 61
31785223 2019
39
[Incidence of chronic obstructive pulmonary disease and pneumoconiosis in different occupational positions among populations from jinchang cohort]. 61
31594118 2019
40
[A case of spontaneous pneumothorax 、mediastinal emphysema and subcutaneous emphysema in pottery pneumoconiosis report]. 61
31594137 2019
41
Cardiovascular Effects of Indoor Air Pollution from Solid Fuel: Relevance to Sub-Saharan Africa. 61
31102183 2019
42
Prevalence of Arthritis and Rheumatoid Arthritis in Coal Mining Counties of the United States. 61
30875457 2019
43
Current Review of Pneumoconiosis Among US Coal Miners. 61
31493280 2019
44
[Influencing factors of no seeking medical treatment among pneumoconiosis patients]. 61
31594117 2019
45
[Analysis of outpatient utilization of pneumoconiosis patients in Jiangsu province]. 61
31594123 2019
46
[Analysis of 235 cases of pneumoconiosis identification in coal enterprises]. 61
31594126 2019
47
[Investigation on social security of pneumoconiosis patients in Chongqing]. 61
31594128 2019
48
[Hospitalized but not admitted and influencing factors for pneumoconiosis patients]. 61
31594131 2019
49
Current Review of Pneumoconiosis Among US Coal Miners. 61
31302880 2019
50
[To accelerate research on policies of social security and salvation and health management for pneumoconiosis cases]. 61
31594116 2019

Variations for Pneumoconiosis

Expression for Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for Pneumoconiosis

Pathways related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 TNF TGFB1 SERPINA1 NLRP3 IL6 IL4
2
Show member pathways
13.94 TNF TGFB1 SPP1 IL6 IL4 IL1B
3
Show member pathways
13.78 TNF TGFB1 IL6 IL4 IL1RN IL1B
4
Show member pathways
13.6 TNF TGFB1 IL6 IL4 IL1B IL10
5
Show member pathways
13.52 TNF TGFB1 IL6 IL4 IL1B IL10
6
Show member pathways
13.47 TNF TGFB1 IL6 IL4 IL1RN IL1B
7
Show member pathways
13.43 TNF TGFB1 IL6 IL4 IL1B IL10
8
Show member pathways
13.19 TNF TGFB1 SPP1 NLRP3 IL6 IL1B
9
Show member pathways
13.1 TNF SPP1 IL6 IL4 FN1 FASLG
10
Show member pathways
13.05 TNF IL6 IL1B FASLG CXCL8 CCL2
11
Show member pathways
13.01 TNF IL6 FN1 FASLG CCL2 CASP8
12 12.98 TGFB1 IL6 IL4 GSTM1 FN1 FASLG
13
Show member pathways
12.95 TNF NLRP3 IL6 IL1B FASLG CXCL8
14
Show member pathways
12.95 TNF TGFB1 IL6 IL4 IL1B IL10
15 12.9 TNF IL6 IL1B FASLG CCL2 CASP8
16 12.82 TNF TGFB1 IL1B FASLG CASP8
17
Show member pathways
12.82 TNF IL6 IL1B CXCL8 CASP8
18
Show member pathways
12.73 TNF TGFB1 IL6 IL4 IL1B IL10
19
Show member pathways
12.72 TNF TGFB1 IL6 IL4 IL1B IL10
20
Show member pathways
12.71 TNF IL6 IL1B IL10 FN1 CCL2
21 12.71 TNF IL4 IL1RN IL1B IL10 FASLG
22
Show member pathways
12.48 TNF IL6 IL4 IL1B CXCL8 CCL2
23
Show member pathways
12.47 TNF SOD1 IL6 IL4 IL1B CCL2
24
Show member pathways
12.46 TNF IL6 IL10 CXCL8 CCL2
25 12.43 TNF NLRP3 IL1B CXCL8
26
Show member pathways
12.43 TNF TGFB1 IL4 IL1B IL10 CASP8
27
Show member pathways
12.43 TNF TGFB1 IL6 IL4 IL1B IL10
28 12.43 TNF NLRP3 IL6 IL1B FASLG CXCL8
29 12.4 TNF TGFB1 IL6 IL1B IL10 CASP8
30
Show member pathways
12.38 TNF IL6 IL1RN IL1B CXCL8 CP
31 12.36 TNF TGFB1 FN1 FASLG
32
Show member pathways
12.36 TNF NLRP3 IL6 IL1B IL10 CASP8
33
Show member pathways
12.35 TNF NLRP3 IL1B FASLG CASP8
34 12.35 TNF NLRP3 IL6 IL1B CXCL8 CCL2
35 12.32 TNF IL6 IL1RN IL1B IL10 CXCL8
36
Show member pathways
12.3 TNF IL6 IL4 IL1B FN1 FASLG
37
Show member pathways
12.23 TGFB1 IL6 IL10 FASLG CAT
38
Show member pathways
12.2 TNF TGFB1 IL6 IL1B IL10
39
Show member pathways
12.19 TNF SOD1 IL6 IL4 IL1B FN1
40 12.18 TNF IL1B GSTM1 CCL2
41 12.13 TNF IL6 IL1B CCL2 CASP8
42 12.12 TNF TGFB1 IL6 IL4 IL1B CXCL8
43 12.11 TGFB1 IL6 IL1B FN1 CXCL8
44 12.1 TNF IL6 IL4 IL10
45 12.05 TNF NLRP3 IL6 IL1B IL10 FN1
46 12.03 TNF TGFB1 IL6 IL1B IL10 FN1
47 12.02 TNF IL6 IL4 IL1B
48 12.01 TNF TGFB1 IL6 IL1B CXCL8 CCL2
49 12 TNF TGFB1 IL6 IL1B FN1 CXCL8
50 11.93 TNF IL4 IL1B IL10

GO Terms for Pneumoconiosis

Cellular components related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 TNF TGFB1 SPP1 SOD1 SERPINA1 NLRP3
2 endoplasmic reticulum lumen GO:0005788 9.55 SPP1 SERPINA1 IL6 FN1 CP
3 extracellular space GO:0005615 9.53 TNF TGFB1 SPP1 SOD1 SERPINA1 IL6
4 platelet alpha granule lumen GO:0031093 9.43 TGFB1 SERPINA1 FN1

Biological processes related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.27 TNF TGFB1 NLRP3 IL6 IL4 IL1B
2 signal transduction GO:0007165 10.24 TGFB1 SPP1 NLRP3 IL6 IL4 IL1RN
3 negative regulation of cell proliferation GO:0008285 10.13 TGFB1 IL6 IL1B IL10 CXCL8
4 positive regulation of transcription, DNA-templated GO:0045893 10.11 TNF TGFB1 SPP1 IL6 IL4 IL1B
5 positive regulation of apoptotic process GO:0043065 10.1 TNF TGFB1 SOD1 IL6 FASLG
6 positive regulation of gene expression GO:0010628 10.08 TNF TGFB1 IL6 IL4 IL1B FN1
7 post-translational protein modification GO:0043687 10.07 SPP1 SERPINA1 IL6 FN1 CP
8 leukocyte migration GO:0050900 10.03 TNF TGFB1 IL1B FN1
9 aging GO:0007568 10.01 TGFB1 SOD1 IL10 CAT
10 response to lipopolysaccharide GO:0032496 10.01 IL1B IL10 FASLG CASP8
11 cellular protein metabolic process GO:0044267 10 SPP1 SERPINA1 IL6 FN1 CP
12 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 TNF IL1RN IL1B FASLG CASP8
13 platelet degranulation GO:0002576 9.93 TGFB1 SOD1 SERPINA1 FN1
14 cellular response to mechanical stimulus GO:0071260 9.92 TGFB1 IL1B CASP8
15 positive regulation of DNA-binding transcription factor activity GO:0051091 9.92 TNF IL6 IL1B IL10
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL6 IL4
17 apoptotic signaling pathway GO:0097190 9.91 TNF FASLG CASP8
18 immune response GO:0006955 9.91 TNF IL6 IL4 IL1RN IL1B IL10
19 positive regulation of T cell proliferation GO:0042102 9.9 IL6 IL4 IL1B
20 humoral immune response GO:0006959 9.89 TNF IL6 CCL2
21 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.89 TNF NLRP3 FASLG CASP8
22 negative regulation of fat cell differentiation GO:0045599 9.88 TNF TGFB1 IL6
23 T cell activation GO:0042110 9.88 TGFB1 IL4 CASP8
24 neutrophil chemotaxis GO:0030593 9.88 IL1RN IL1B CXCL8 CCL2
25 positive regulation of cell division GO:0051781 9.86 TGFB1 IL1B CAT
26 positive regulation of phagocytosis GO:0050766 9.86 TNF SOD1 IL1B
27 positive regulation of epithelial to mesenchymal transition GO:0010718 9.85 TGFB1 IL6 IL1B
28 embryo implantation GO:0007566 9.84 SPP1 SOD1 IL1B
29 negative regulation of mitotic cell cycle GO:0045930 9.84 TNF TGFB1 IL10
30 response to glucocorticoid GO:0051384 9.84 TNF IL6 IL1RN IL10
31 acute-phase response GO:0006953 9.83 SERPINA1 IL6 FN1
32 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.83 TNF FASLG CASP8
33 positive regulation of interleukin-6 production GO:0032755 9.83 TNF IL6 IL1RN IL1B
34 positive regulation of JAK-STAT cascade GO:0046427 9.8 TNF IL6 IL10
35 response to organic substance GO:0010033 9.8 TNF TGFB1 SPP1 SOD1 IL10
36 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 TNF TGFB1 NLRP3 IL6 IL1B CAT
37 positive regulation of vascular endothelial growth factor production GO:0010575 9.79 TGFB1 IL6 IL1B
38 negative regulation of neurogenesis GO:0050768 9.79 TNF IL6 IL1B
39 extrinsic apoptotic signaling pathway GO:0097191 9.78 TNF TGFB1 FASLG CASP8
40 cellular response to organic cyclic compound GO:0071407 9.77 TNF TGFB1 IL1B CCL2 CASP8
41 protein kinase B signaling GO:0043491 9.76 TNF TGFB1 IL1B CCL2
42 cellular response to lipopolysaccharide GO:0071222 9.76 TNF NLRP3 IL6 IL1RN IL1B IL10
43 positive regulation of glial cell proliferation GO:0060252 9.75 TNF IL6 IL1B
44 positive regulation of MHC class II biosynthetic process GO:0045348 9.74 IL4 IL10
45 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.74 IL4 IL10
46 positive regulation of interleukin-13 production GO:0032736 9.74 NLRP3 IL4
47 negative regulation of lipid storage GO:0010888 9.73 TNF IL6
48 endothelial cell apoptotic process GO:0072577 9.73 TNF IL10
49 death-inducing signaling complex assembly GO:0071550 9.73 TNF CASP8
50 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.73 TNF IL1B IL10

Molecular functions related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.72 TGFB1 SOD1 GSTM1 FN1 CAT
2 growth factor activity GO:0008083 9.56 TGFB1 IL6 IL4 IL10
3 identical protein binding GO:0042802 9.56 TNF TGFB1 SOD1 SERPINA1 NLRP3 FN1
4 cytokine activity GO:0005125 9.36 TNF TGFB1 SPP1 IL6 IL4 IL1RN
5 tumor necrosis factor receptor binding GO:0005164 9.33 TNF FASLG CASP8

Sources for Pneumoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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