MCID: PNM006
MIFTS: 55

Pneumoconiosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Pneumoconiosis

MalaCards integrated aliases for Pneumoconiosis:

Name: Pneumoconiosis 12 74 58 54 44 15 71

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:10316
ICD9CM 34 505
MeSH 44 D011009
NCIt 50 C26861
SNOMED-CT 67 196004000
MESH via Orphanet 45 D011009
UMLS via Orphanet 72 C0032273
Orphanet 58 ORPHA182098
UMLS 71 C0032273

Summaries for Pneumoconiosis

Disease Ontology : 12 An interstitial lung disease that is caused by the inhalation of dust.

MalaCards based summary : Pneumoconiosis is related to anthracosis and beryllium disease. An important gene associated with Pneumoconiosis is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Nintedanib and Pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and lymph node, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Pneumoconiosis is the general term for a class of interstitial lung diseases where inhalation of dust... more...

Related Diseases for Pneumoconiosis

Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 770)
# Related Disease Score Top Affiliating Genes
1 anthracosis 33.0 TNF TGFB1 IL6 IL1B CXCL8 CCL2
2 beryllium disease 32.0 TNF TGFB1
3 asbestosis 31.8 SERPINA1 OGG1 NLRP3 IL6 GSTM1
4 silicosis 31.3 TNF TGFB1 NLRP3 IL4 IL1RN IL1B
5 pulmonary fibrosis 31.3 TGFB1 IL1RN IL1B CXCL8 CCL2
6 anthracosilicosis 31.1 IL1B CP
7 pulmonary tuberculosis 30.7 TNF IL6 IL4 IL10 CP CCL2
8 chronic beryllium disease 30.7 TNF TGFB1
9 sarcoidosis 1 30.7 TNF IL1RN IL1B IL1A CCL2
10 bronchitis 30.6 TNF SERPINA1 IL6 IL4 IL1B IL10
11 pleural disease 30.4 TNF IL6 IL1B CXCL8
12 pulmonary alveolar proteinosis 30.4 TNF IL6 IL10 CXCL8 CCL2
13 haemophilus influenzae 30.3 TNF CXCL8
14 bronchiectasis 30.2 TNF SERPINA1 IL6 IL1B CXCL8
15 aspergillosis 30.2 TNF IL6 IL4 IL1B IL1A IL10
16 respiratory failure 30.2 TNF SERPINA1 IL6 IL1RN IL1B IL1A
17 lung disease 30.2 TNF TGFB1 SERPINA1 IL6 IL4 IL1B
18 pleurisy 30.2 TNF TGFB1 IL1RN CXCL8 CCL2
19 pulmonary edema 30.2 TNF IL1B IL10 CXCL8
20 pleural tuberculosis 30.1 TNF CXCL8 CCL2
21 interstitial lung disease 30.1 TNF TGFB1 IL6 IL4 IL1B IL1A
22 pericarditis 30.1 TNF IL6 IL1B CXCL8
23 echinococcosis 30.1 TNF IL6 IL10
24 extrinsic allergic alveolitis 30.1 IL6 IL1B IL1A IL10 FN1 CXCL8
25 peptic ulcer disease 30.1 TNF IL1RN IL1B IL10 CXCL8
26 systemic scleroderma 30.0 TNF TGFB1 IL6 IL4 IL10 FN1
27 mycobacterium kansasii 30.0 NLRP3 FN1 CXCL8
28 congestive heart failure 30.0 TNF IL6 IL1B FN1
29 vasculitis 30.0 TNF SERPINA1 IL6 CCL2
30 pulmonary disease, chronic obstructive 30.0 TNF TGFB1 SERPINA1 IL6 IL4 IL1B
31 cryptococcosis 29.9 TNF IL4 IL10
32 pneumonia 29.9 TNF SERPINA1 IL6 IL4 IL1B IL10
33 gout 29.9 TNF NLRP3 IL6 IL1B CXCL8
34 bronchopneumonia 29.9 TNF IL6 IL1B IL10 CXCL8
35 bronchiolitis obliterans 29.9 TNF TGFB1 IL6 IL10 CXCL8
36 endocarditis 29.8 TNF IL6 IL1A IL10 CXCL8
37 liver cirrhosis 29.8 TNF TGFB1 SERPINA1 IL6 IL1B IL10
38 pulmonary eosinophilia 29.8 SERPINA1 IL4 CXCL8
39 pancreatitis 29.8 TNF SERPINA1 IL6 IL1B IL10
40 severe acute respiratory syndrome 29.7 TNF IL6 IL1B IL10 CXCL8 CCL2
41 vascular disease 29.7 TNF TGFB1 IL6 IL1A IL10 FN1
42 bronchiolitis 29.7 TNF IL6 IL4 IL1B IL10 CXCL8
43 pulmonary hypertension 29.7 TNF TGFB1 SERPINA1 IL6 IL1B IL1A
44 paranasal sinus disease 29.6 TNF TGFB1 IL6 IL4 IL10 CXCL8
45 esophagitis 29.6 TNF IL6 IL4 IL1B IL10 CXCL8
46 tonsillitis 29.5 TNF IL6 IL4 IL1B IL1A IL10
47 bacterial infectious disease 29.5 TNF IL6 IL1RN IL1B IL1A IL10
48 myelodysplastic syndrome 29.4 TNF IL6 IL1B IL1A IL10 GSTM1
49 bladder cancer 29.4 TNF OGG1 H19 GSTM1 FN1 CXCL8
50 connective tissue disease 29.4 TNF IL6 IL4 IL1B IL1A IL10

Comorbidity relations with Pneumoconiosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Familial Atrial Fibrillation Heart Disease
Postinflammatory Pulmonary Fibrosis Prostatic Hypertrophy
Respiratory Failure

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to Pneumoconiosis

Symptoms & Phenotypes for Pneumoconiosis

GenomeRNAi Phenotypes related to Pneumoconiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.9 CASP8
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.9 CASP8 FAS FASLG IL10 IL1A IL1B
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.9 CASP8 IL1A
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 CXCL8 FAS IL10 IL1A IL1B NLRP3
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 CXCL8 FAS IL10 IL1B NLRP3 TGFB1
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.53 CASP8
7 Reduced mammosphere formation GR00396-S 9.5 CCL2 CXCL8 FAS FASLG GSTM1 H19

MGI Mouse Phenotypes related to Pneumoconiosis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.37 CASP8 CP FAS FASLG FN1 IL10
2 immune system MP:0005387 10.36 CASP8 CCL2 CP FAS FASLG FN1
3 homeostasis/metabolism MP:0005376 10.35 CASP8 CP FAS FASLG FN1 IL10
4 cellular MP:0005384 10.34 CASP8 CP FAS FASLG FN1 IL10
5 cardiovascular system MP:0005385 10.31 CASP8 CP FAS FASLG FN1 IL10
6 integument MP:0010771 10.25 CASP8 FAS FASLG FN1 IL10 IL1A
7 mortality/aging MP:0010768 10.21 CASP8 FAS FASLG FN1 IL10 IL1B
8 liver/biliary system MP:0005370 10.18 CASP8 CP FAS FASLG FN1 IL10
9 digestive/alimentary MP:0005381 10.11 FAS FASLG IL10 IL4 IL6 NLRP3
10 nervous system MP:0003631 10.07 CASP8 CP FAS FASLG FN1 IL10
11 neoplasm MP:0002006 10.06 CASP8 FAS FASLG FN1 IL10 IL1A
12 reproductive system MP:0005389 9.85 FAS FASLG FN1 IL10 IL1RN IL4
13 respiratory system MP:0005388 9.56 CASP8 FAS FASLG IL10 IL4 IL6
14 skeleton MP:0005390 9.36 FAS FASLG FN1 IL10 IL1B IL1RN

Drugs & Therapeutics for Pneumoconiosis

Drugs for Pneumoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nintedanib Approved Phase 2 656247-17-5 56843413
2
Pirfenidone Approved, Investigational Phase 2 53179-13-8 40632
3 Anti-Inflammatory Agents Phase 2
4 Analgesics, Non-Narcotic Phase 2
5 Anti-Inflammatory Agents, Non-Steroidal Phase 2
6 Analgesics Phase 2
7 Antirheumatic Agents Phase 2
8
Cocaine Approved, Illicit 50-36-2 5760 446220

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial Recruiting NCT04161014 Phase 2 Nintedanib 150 MG [Ofev]
2 Examination of Pirfenidone (Esbriet®) Therapy in Coal Workers' Pneumoconiosis With Pulmonary Fibrosis Associated With Radiographic and Functional Impairment to Examine the Reduction in Progression of Disease, Reduction of Exacerbation Rates and Possible Reduction of Inflammatory Biomarkers as an Index of Clinical Response. Recruiting NCT04461587 Phase 2 Pirfenidone
3 A Phase I Study of Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Unknown status NCT02790762 Phase 1
4 A Multicenter, Randomized, Single-blind, Parallel-group Study of Combined Large Volume WLL With Clinical Grade Umbilical Cord Mesenchymal Stem Cells(MSC) Transplantation for Treatment of Pneumoconiosis Completed NCT02668068 Phase 1
5 The Experience of Patients and Family Caregivers in Managing Pneumoconiosis in the Family Context: An Exploratory Qualitative Study Completed NCT04022902
6 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
7 Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma Recruiting NCT04205708

Search NIH Clinical Center for Pneumoconiosis

Cochrane evidence based reviews: pneumoconiosis

Genetic Tests for Pneumoconiosis

Anatomical Context for Pneumoconiosis

MalaCards organs/tissues related to Pneumoconiosis:

40
Lung, Heart, Lymph Node, Skin, Eye, Thyroid, Neutrophil

Publications for Pneumoconiosis

Articles related to Pneumoconiosis:

(show top 50) (show all 4230)
# Title Authors PMID Year
1
[Regulation role of superoxide dismutase coenzyme on Fas/FasL signal transduction and apoptosis in alveolar macrophages of pneumoconiosis patients]. 54 61
18727868 2008
2
[Activity of superoxide dismutase and level of lipid peroxidation in pneumoconiosis patients]. 61 54
17908436 2007
3
[Significance of serum sialic acid and ceruloplasmin in early lung fibrosis of pneumoconiosis]. 61 54
16600124 2006
4
Blood antioxidant enzymes as markers of exposure or effect in coal miners. 61 54
8563856 1996
5
[Free radial activity in patients with pneumoconioses]. 61 54
8629354 1996
6
Mortality from silicosis in Brazil: Temporal trends in the period 1980-2017. 61
33410169 2021
7
Macrophage autophagy protects mice from cerium oxide nanoparticle-induced lung fibrosis. 61
33526046 2021
8
Respiratory traits and coal workers' pneumoconiosis: Mendelian randomisation and association analysis. 61
33097673 2021
9
Development of a multimedia intervention to improve pneumoconiosis prevention in construction workers using RE-AIM framework. 61
33576371 2021
10
Automated detection of pneumoconiosis with multilevel deep features learned from chest X-Ray radiographs. 61
33310394 2021
11
Characterizing patterns of small pneumoconiotic opacities on chest radiographs of New Mexico coal miners. 61
33583358 2021
12
A Nurse-Led Education Program for Pneumoconiosis Caregivers at the Community Level. 61
33530598 2021
13
A deep learning-based model for screening and staging pneumoconiosis. 61
33500426 2021
14
Omics Approaches for Exploring Pneumoconiosis: A Review. 61
33531110 2021
15
Analysis of Health Service Utilization and its Influencing Factors among Patients with Pneumoconiosis in China. 61
33531111 2021
16
Alteration of thiol disulfide homeostasis and ischemia-modified albumin levels as indicators of oxidative status in patients with silicosis. 61
33305688 2021
17
The relationship between respiratory health and hard metal dust exposure: A cross-sectional study. 61
33432872 2021
18
Changes in Health-Related Quality of Life During the First Year in Lung Transplant Recipients. 61
32768289 2021
19
Costs of asbestosis and silicosis hospitalization in Italy (2001-2018) : Costs of asbestosis and silicosis hospitalization. 61
33404732 2021
20
Single intratracheal administration of cross-linked water-soluble acrylic acid polymer causes acute alveolo-interstitial inflammation and the subsequent fibrotic formation possibly via the TGF-β1 pathway in the lung of rats. 61
33259820 2021
21
Sex-Related Differences in the Risk of Silicosis Among Chinese Pottery Workers: A Cohort Study. 61
33122539 2021
22
[Differential expression of PRDX4 in alveolar macrophages of patients with silicosis]. 61
33535333 2021
23
[Research progress in pathogenesis of pneumoconiosis]. 61
33406565 2020
24
Assessment of pneumoconiosis in surface coal miners after implementation of a national radiographic surveillance program, United States, 2014-2019. 61
32914897 2020
25
Coal Workers' Pneumoconiosis and Other Mining-Related Lung Disease: New Manifestations of Illness in an Age-Old Occupation. 61
33153687 2020
26
Eye Tracking to Evaluate the Usability of an Online Pneumoconiosis Education Booklet in a Sample of South Asian Construction Workers. 61
32541364 2020
27
COVID 19 pandemic: Mental health challenges of internal migrant workers of India. 61
32593122 2020
28
[Study on changes of pulmonary function in patients with pneumoconiosis in three years]. 61
33406545 2020
29
Health Disparities in Environmental and Occupational Lung Disease. 61
33153683 2020
30
Occupational Contributions to Interstitial Lung Disease. 61
33153688 2020
31
Superior mediastinal lymphadenopathy by silicosis mimicking metastasis of papillary thyroid carcinoma - Case report and literature review. 61
31899060 2020
32
Mediation and Moderation of an Educational Intervention for Improving Intention to Practise Pneumoconiosis Prevention Among South Asian Construction Workers. 61
32991377 2020
33
Telomerase gene variants and telomere shortening in patients with silicosis or asbestosis. 61
33323453 2020
34
[A comparative study on diagnosis of silicosis by digital and high kV film-screen chest radiography]. 61
33406553 2020
35
Progression of coal workers' pneumoconiosis absent further exposure. 61
32788293 2020
36
Pneumoconiosis with a Sarcoid-Like Reaction Other than Beryllium Exposure: A Case Report and Literature Review. 61
33266389 2020
37
Silica-related diseases in the modern world. 61
31989662 2020
38
Transplantation for work-related lung disease in the USA. 61
32859693 2020
39
A Landscape of lncRNA Expression Profile and the Predictive Value of a Candidate lncRNA for Silica-Induced Pulmonary Fibrosis. 61
33202189 2020
40
Causes of death among Federal Black Lung Benefits Program beneficiaries enrolled in Medicare, 1999-2016. 61
32914887 2020
41
Percutaneous CT-guided lung biopsy for the diagnosis of persistent pulmonary consolidation. 61
32811758 2020
42
[Application of SF-36 scale in the survey of quality of life of occupational disease patients]. 61
33287480 2020
43
The impacts of coal dust on miners' health: A review. 61
32763275 2020
44
[Analysis of the diagnotic results and complications of pneumoconiosis patients with different insurance types]. 61
33142374 2020
45
[Analysis of the diagnostic value of combined different chest X-ray image features for pneumoconiosis-associated tuberculosis]. 61
33142383 2020
46
[Epidemiological characteristics of pneumoconiosis in Gansu Province from 2010 to 2018]. 61
33142377 2020
47
Transcriptome profile analysis reveals a silica-induced immune response and fibrosis in a silicosis rat model. 61
32721576 2020
48
Respiratory rehabilitation for post-COVID19 patients in spa centers: first steps from theory to practice. 61
32710297 2020
49
Magnetic targeting increases mesenchymal stromal cell retention in lungs and enhances beneficial effects on pulmonary damage in experimental silicosis. 61
32538526 2020
50
[Research progress on the effects of welding fumes exposure on lung]. 61
33142391 2020

Variations for Pneumoconiosis

Expression for Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for Pneumoconiosis

Pathways related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.16 TNF TGFB1 SERPINA1 NLRP3 IL6 IL4
2
Show member pathways
13.97 TNF TGFB1 IL6 IL4 IL1B IL1A
3
Show member pathways
13.82 TNF TGFB1 IL6 IL4 IL1RN IL1B
4
Show member pathways
13.64 TNF TGFB1 IL6 IL4 IL1B IL1A
5
Show member pathways
13.57 TNF TGFB1 IL6 IL4 IL1B IL1A
6
Show member pathways
13.46 TNF TGFB1 IL6 IL4 IL1RN IL1B
7
Show member pathways
13.44 TNF TGFB1 IL6 IL1B IL1A FASLG
8
Show member pathways
13.41 TNF TGFB1 IL6 IL4 IL1B IL1A
9
Show member pathways
13.21 TNF TGFB1 IL6 IL1B IL10 FASLG
10
Show member pathways
13.18 TNF IL6 FN1 FASLG FAS CCL2
11
Show member pathways
13.12 TNF IL6 IL4 FN1 FASLG FAS
12
Show member pathways
13.11 TNF IL6 IL1B FASLG FAS CXCL8
13 13.02 TGFB1 IL6 IL4 GSTM1 FN1 FASLG
14
Show member pathways
12.97 TNF NLRP3 IL6 IL1B IL1A FASLG
15 12.96 TNF IL6 IL1B FASLG FAS CCL2
16
Show member pathways
12.93 TNF NLRP3 IL6 IL1B FASLG FAS
17 12.92 TNF TGFB1 IL1B IL1A FASLG FAS
18
Show member pathways
12.91 TNF NLRP3 IL6 IL1RN IL1B IL1A
19
Show member pathways
12.89 TNF TGFB1 IL6 IL4 IL1B IL1A
20
Show member pathways
12.79 TNF TGFB1 IL6 IL1B IL1A
21
Show member pathways
12.79 TNF TGFB1 IL6 IL4 IL1B IL1A
22
Show member pathways
12.79 TNF TGFB1 IL6 IL4 IL1B IL1A
23
Show member pathways
12.76 TNF IL1B IL1A FASLG FAS
24
Show member pathways
12.74 TNF IL6 IL1B IL10 FN1 CCL2
25
Show member pathways
12.74 TNF IL1B IL1A FASLG FAS CASP8
26 12.73 TNF IL4 IL1RN IL1B IL10 FASLG
27
Show member pathways
12.53 TNF IL6 IL4 IL1B CXCL8 CCL2
28 12.47 TNF NLRP3 IL1B CXCL8
29
Show member pathways
12.47 TNF IL6 IL10 CXCL8 CCL2
30
Show member pathways
12.47 TNF IL6 IL4 IL1B CCL2
31 12.45 TNF TGFB1 FN1 FASLG FAS
32
Show member pathways
12.45 TNF TGFB1 IL6 IL4 IL1B IL1A
33
Show member pathways
12.45 TNF TGFB1 IL4 IL1B IL1A IL10
34
Show member pathways
12.44 TNF IL6 IL1B IL1A CXCL8
35
Show member pathways
12.42 TNF NLRP3 IL6 IL1B IL10 CASP8
36
Show member pathways
12.41 TNF FASLG FAS CASP8
37 12.41 TNF NLRP3 IL6 IL1B CXCL8 CCL2
38 12.4 TNF TGFB1 IL6 IL1B IL1A IL10
39
Show member pathways
12.38 IL1RN IL1B IL1A CCL2
40
Show member pathways
12.38 TNF IL1A FASLG FAS CASP8
41
Show member pathways
12.37 TNF NLRP3 IL1B IL1A FASLG FAS
42
Show member pathways
12.35 TNF IL6 IL1A CXCL8
43 12.34 TNF FASLG FAS CASP8
44 12.34 TNF IL6 IL1RN IL1B IL1A IL10
45
Show member pathways
12.33 TNF IL6 IL4 IL1B FN1 FASLG
46 12.26 TGFB1 IL6 IL1A CXCL8
47 12.26 TNF IL1B IL1A GSTM1 CCL2
48 12.23 TNF IL1B FAS CASP8
49 12.22 TNF NLRP3 IL6 IL1B IL10 FN1
50
Show member pathways
12.19 TGFB1 IL6 IL10 FASLG

GO Terms for Pneumoconiosis

Cellular components related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 TNF TGFB1 SERPINA1 IL6 IL4 IL1RN
2 extracellular region GO:0005576 9.53 TNF TGFB1 SERPINA1 NLRP3 IL6 IL4
3 platelet alpha granule lumen GO:0031093 9.5 TGFB1 SERPINA1 FN1
4 death-inducing signaling complex GO:0031264 9.26 FAS CASP8
5 CD95 death-inducing signaling complex GO:0031265 9.16 FAS CASP8

Biological processes related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.34 NLRP3 IL6 IL4 IL1RN IL1B IL10
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.27 TNF TGFB1 NLRP3 IL6 IL4 IL1A
3 positive regulation of transcription, DNA-templated GO:0045893 10.2 TNF TGFB1 IL6 IL4 IL1B IL10
4 apoptotic process GO:0006915 10.19 NLRP3 IL1B IL1A FASLG FAS CASP8
5 positive regulation of cell proliferation GO:0008284 10.16 TGFB1 IL6 IL4 IL1B FN1 FASLG
6 negative regulation of cell proliferation GO:0008285 10.11 TGFB1 IL6 IL1B IL1A IL10 CXCL8
7 positive regulation of apoptotic process GO:0043065 10.08 TNF TGFB1 IL6 FASLG FAS CASP8
8 cellular protein metabolic process GO:0044267 10.04 SERPINA1 IL6 FN1 CP
9 positive regulation of protein phosphorylation GO:0001934 10.03 TNF TGFB1 IL1B FAS
10 response to lipopolysaccharide GO:0032496 10.01 IL1B IL10 FASLG CASP8
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF TGFB1 NLRP3 IL6 IL1B
12 positive regulation of gene expression GO:0010628 9.97 TNF TGFB1 IL6 IL4 IL1B IL1A
13 positive regulation of DNA-binding transcription factor activity GO:0051091 9.95 TNF IL6 IL1B IL10
14 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.93 TNF FASLG FAS CASP8
15 regulation of insulin secretion GO:0050796 9.92 TNF IL6 IL1B
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL6 IL4
17 positive regulation of interleukin-6 production GO:0032755 9.92 TNF IL6 IL1B IL1A
18 cellular response to mechanical stimulus GO:0071260 9.92 TGFB1 IL1B FAS CASP8
19 positive regulation of T cell proliferation GO:0042102 9.91 IL6 IL4 IL1B
20 inflammatory response GO:0006954 9.91 TNF TGFB1 NLRP3 IL6 IL1RN IL1B
21 positive regulation of interleukin-8 production GO:0032757 9.9 TNF IL6 IL1B
22 humoral immune response GO:0006959 9.9 TNF IL6 CCL2
23 positive regulation of cytokine production GO:0001819 9.9 TNF IL1A IL10
24 negative regulation of fat cell differentiation GO:0045599 9.89 TNF TGFB1 IL6
25 apoptotic signaling pathway GO:0097190 9.89 TNF FASLG FAS CASP8
26 positive regulation of cell division GO:0051781 9.88 TGFB1 IL1B IL1A
27 T cell activation GO:0042110 9.88 TGFB1 IL4 CASP8
28 response to glucocorticoid GO:0051384 9.88 TNF IL6 IL1RN IL10
29 positive regulation of epithelial to mesenchymal transition GO:0010718 9.87 TGFB1 IL6 IL1B
30 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.87 TNF TGFB1 IL10
31 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.86 FASLG FAS CASP8
32 negative regulation of mitotic cell cycle GO:0045930 9.86 TNF TGFB1 IL10
33 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.85 TNF IL1B IL1A
34 positive regulation of interleukin-1 beta production GO:0032731 9.85 TNF NLRP3 IL6 CASP8
35 liver regeneration GO:0097421 9.84 TGFB1 IL6 IL10
36 positive regulation of JAK-STAT cascade GO:0046427 9.84 TNF IL6 IL10
37 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.83 IL4 IL1A FAS
38 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.83 TNF FASLG CASP8
39 protein kinase B signaling GO:0043491 9.83 TNF TGFB1 IL1B CCL2
40 negative regulation of neurogenesis GO:0050768 9.82 TNF IL6 IL1B
41 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.82 TNF IL6 H19
42 acute-phase response GO:0006953 9.81 SERPINA1 IL6 IL1RN FN1
43 cellular response to organic cyclic compound GO:0071407 9.8 TNF TGFB1 IL1B CCL2 CASP8
44 positive regulation of glial cell proliferation GO:0060252 9.79 TNF IL6 IL1B
45 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.78 FASLG FAS CASP8
46 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 TNF IL1B IL10
47 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 TNF TGFB1 IL1B CCL2
48 cellular response to lipopolysaccharide GO:0071222 9.76 TNF NLRP3 IL6 IL1B IL1A IL10
49 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.75 TNF TGFB1
50 positive regulation of MHC class II biosynthetic process GO:0045348 9.75 IL4 IL10

Molecular functions related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 TGFB1 IL6 IL4 IL10
2 cytokine activity GO:0005125 9.36 TNF TGFB1 IL6 IL4 IL1RN IL1B
3 tumor necrosis factor receptor binding GO:0005164 9.33 TNF FASLG CASP8
4 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A

Sources for Pneumoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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