MCID: PNM006
MIFTS: 55

Pneumoconiosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Pneumoconiosis

Summaries for Pneumoconiosis

Disease Ontology : 12 An interstitial lung disease that is caused by the inhalation of dust.

MalaCards based summary : Pneumoconiosis is related to anthracosis and asbestosis. An important gene associated with Pneumoconiosis is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Amlodipine and Metoprolol have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 75 Pneumoconiosis is the general term for a class of interstitial lung diseases where inhalation of dust... more...

Related Diseases for Pneumoconiosis

Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 361)
# Related Disease Score Top Affiliating Genes
1 anthracosis 34.7 TNF SOD1 CCL2
2 asbestosis 32.8 SERPINA1 IL6 GSTM1
3 silicosis 31.7 TNF TGFB1 NLRP3 IL1B FASLG FAS
4 idiopathic interstitial pneumonia 31.5 TGFB1 CXCL8 CCL2
5 bronchitis 31.2 TNF SERPINA1 CXCL8
6 haemophilus influenzae 30.8 TNF IL1B CXCL8
7 autoimmune disease 30.7 TNF IL6 IL1B FAS
8 arteries, anomalies of 30.7 TNF IL6 IL1B CCL2
9 peptic ulcer disease 30.7 TNF IL1B CXCL8
10 pericarditis 30.6 TNF IL6 IL1B
11 pulmonary edema 30.6 TNF IL1B CXCL8
12 pleurisy 30.6 TNF CXCL8 CCL2
13 extrinsic allergic alveolitis 30.6 IL6 IL1B CXCL8 CCL2
14 pneumonia 30.5 TNF IL6 IL1B CXCL8 CCL2
15 respiratory failure 30.5 TNF SERPINA1 CXCL8
16 bronchiolitis obliterans 30.4 TNF IL6 CXCL8
17 bronchiolitis 30.4 TNF IL6 CXCL8
18 interstitial lung disease 30.4 TNF TGFB1 IL6 IL1B CXCL8 CCL2
19 pleural tuberculosis 30.4 TNF CXCL8 CCL2
20 endocarditis 30.4 TNF IL6 CXCL8
21 heart disease 30.3 TNF IL6 IL1B H19 CXCL8
22 severe acute respiratory syndrome 30.3 TNF CXCL8 CCL2
23 esophagitis 30.3 TGFB1 IL6 IL1B CXCL8
24 sleep apnea 30.3 TNF IL6 IL1B CXCL8
25 arthritis 30.1 TNF TGFB1 IL6 IL1B CXCL8 CCL2
26 lung disease 30.1 TNF TGFB1 SERPINA1 IL6 IL1B CXCL8
27 vascular disease 30.0 TNF SOD1 IL6 CCL2 CAT
28 vasculitis 30.0 TNF SERPINA1 CCL2
29 pulmonary fibrosis, idiopathic 30.0 TNF TGFB1 IL1B FASLG CXCL8 CCL2
30 tonsillitis 30.0 TNF SOD1 IL6 IL1B CXCL8
31 bacterial infectious disease 29.8 TNF IL6 IL1B CXCL8 CCL2
32 pulmonary disease, chronic obstructive 29.4 TNF TGFB1 SERPINA1 IL6 GSTM1 CXCL8
33 mycobacterium kansasii 29.3 NLRP3 FN1 CXCL8
34 rheumatoid arthritis 29.2 TNF TGFB1 IL6 IL1B H19 CXCL8
35 hepatocellular carcinoma 28.0 TGFB1 SERPINA1 IL6 H19 GSTM1 FASLG
36 asthma 27.0 TNF NLRP3 IL6 IL1B FAS CXCL8
37 kaolin pneumoconiosis 12.7
38 pneumoconiosis due to talc 12.5
39 graphite pneumoconiosis 12.4
40 mixed mineral dust pneumoconiosis 12.2
41 labrador lung 12.2
42 slate pneumoconiosis 12.2
43 caplan's syndrome 12.1
44 aluminosis 12.1
45 silicosiderosis 11.9
46 siderosis 11.7
47 baritosis 11.7
48 berylliosis 11.7
49 nontuberculous mycobacterial lung disease 11.2
50 asbestos intoxication 11.1

Comorbidity relations with Pneumoconiosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Familial Atrial Fibrillation Heart Disease
Postinflammatory Pulmonary Fibrosis Prostatic Hypertrophy
Respiratory Failure

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to Pneumoconiosis

Symptoms & Phenotypes for Pneumoconiosis

GenomeRNAi Phenotypes related to Pneumoconiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.84 CASP8 CXCL8 FAS IL1B NLRP3 SOD1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.84 CASP8 CXCL8 FAS IL1B NLRP3 SOD1
3 Reduced mammosphere formation GR00396-S 9.56 CCL2 CXCL8 FAS FASLG GSTM1 H19

MGI Mouse Phenotypes related to Pneumoconiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 CASP8 CAT CP FAS FASLG FN1
2 cardiovascular system MP:0005385 10.18 CASP8 CP FAS FASLG FN1 IL1B
3 homeostasis/metabolism MP:0005376 10.18 CASP8 CAT CP FAS FASLG FN1
4 hematopoietic system MP:0005397 10.17 CASP8 CP FAS FASLG FN1 IL1B
5 immune system MP:0005387 10.15 CASP8 CCL2 CP FAS FASLG FN1
6 integument MP:0010771 10.02 CASP8 FAS FASLG FN1 IL1B IL6
7 liver/biliary system MP:0005370 9.96 CASP8 CP FAS FASLG FN1 IL6
8 neoplasm MP:0002006 9.85 CASP8 CAT FAS FASLG FN1 IL1B
9 nervous system MP:0003631 9.7 CASP8 CP FAS FASLG FN1 IL1B
10 skeleton MP:0005390 9.28 FAS FASLG FN1 IL1B IL6 NLRP3

Drugs & Therapeutics for Pneumoconiosis

Drugs for Pneumoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
2
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
3
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
4 Neurotransmitter Agents Phase 2, Phase 3
5 Antihypertensive Agents Phase 2, Phase 3
6 Hormones Phase 2, Phase 3
7 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
8 Peripheral Nervous System Agents Phase 2, Phase 3
9 Adrenergic beta-Antagonists Phase 2, Phase 3
10 Adrenergic Antagonists Phase 2, Phase 3
11 Adrenergic Agents Phase 2, Phase 3
12 Sympatholytics Phase 2, Phase 3
13 Anti-Arrhythmia Agents Phase 2, Phase 3
14 Vasodilator Agents Phase 2, Phase 3
15 calcium channel blockers Phase 2, Phase 3
16 Autonomic Agents Phase 2, Phase 3
17 Calcium, Dietary Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Study Was Approved by the Ethics Committee of Our Institution, Which is Accredited by the Office of Human Research Protection as an Institutional Review Board Unknown status NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
2 A Phase I Study of Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Unknown status NCT02790762 Phase 1
3 A Multicenter, Randomized, Single-blind, Parallel-group Study of Combined Large Volume WLL With Clinical Grade Umbilical Cord Mesenchymal Stem Cells(MSC) Transplantation for Treatment of Pneumoconiosis Completed NCT02668068 Phase 1
4 Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed in Patients With Emphysema and Interstitial Fibrosis Compared to Non-diseased Areas Unknown status NCT02705144
5 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
6 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
7 The Experience of Patients and Family Caregivers in Managing Pneumoconiosis in the Family Context: An Exploratory Qualitative Study Recruiting NCT04022902
8 Palliative Care Coaching for Family Caregivers & Patients With Rare Advanced Lung Disease Recruiting NCT03813667

Search NIH Clinical Center for Pneumoconiosis

Cochrane evidence based reviews: pneumoconiosis

Genetic Tests for Pneumoconiosis

Anatomical Context for Pneumoconiosis

MalaCards organs/tissues related to Pneumoconiosis:

41
Lung, Testes, Heart, Lymph Node, Liver, Neutrophil, Bone

Publications for Pneumoconiosis

Articles related to Pneumoconiosis:

(show top 50) (show all 4023)
# Title Authors PMID Year
1
[Regulation role of superoxide dismutase coenzyme on Fas/FasL signal transduction and apoptosis in alveolar macrophages of pneumoconiosis patients]. 9 38
18727868 2008
2
[Activity of superoxide dismutase and level of lipid peroxidation in pneumoconiosis patients]. 9 38
17908436 2007
3
[Significance of serum sialic acid and ceruloplasmin in early lung fibrosis of pneumoconiosis]. 9 38
16600124 2006
4
[Free radial activity in patients with pneumoconioses]. 9 38
8629354 1996
5
Blood antioxidant enzymes as markers of exposure or effect in coal miners. 9 38
8563856 1996
6
Targeting the RAS axis alleviates silicotic fibrosis and Ang II-induced myofibroblast differentiation via inhibition of the hedgehog signaling pathway. 38
31181250 2019
7
Cardiovascular Effects of Indoor Air Pollution from Solid Fuel: Relevance to Sub-Saharan Africa. 38
31102183 2019
8
Current Review of Pneumoconiosis Among US Coal Miners. 38
31302880 2019
9
Comparison of the International Classification of High-resolution Computed Tomography for occupational and environmental respiratory diseases with the International Labor Organization International Classification of Radiographs of Pneumoconiosis. 38
30344228 2019
10
Usefulness of occupation and industry information in mortality data in South Africa from 2006 to 2015. 38
31269939 2019
11
'X-rays don't tell lies': the Medical Research Council and the measurement of respiratory disability, 1936-1945. 38
31327321 2019
12
Continued increase in prevalence of r-type opacities among underground coal miners in the USA. 38
31023786 2019
13
China's dusty lung crisis: Rural-urban health inequity as social and spatial injustice. 38
31229908 2019
14
N-acetylcysteine tiherapeutically protects against pulmonary fibrosis in a mouse model of silicosis. 38
31273057 2019
15
The clinical value of F-18 FDG PET/CT in differentiating malignant from benign lesions in pneumoconiosis patients. 38
31338654 2019
16
Prediction of the length of service at the onset of coal workers' pneumoconiosis based on neural network. 38
31328665 2019
17
[Introduction to Professor Ma Guiqin's experience in treatment of occupational pneumoconiosis]. 38
31359703 2019
18
Association between Occupational and Radiological Factors and Nontuberculous Mycobacteria Lung Infection in Workers with Prior Dust Exposure. 38
31163598 2019
19
The utility of health belief model to explain self-protective behaviour against pneumoconiosis in Chinese underground coal miners: a cross-sectional study. 38
31167866 2019
20
Respirable coal mine dust in underground mines, United States, 1982-2017. 38
31033017 2019
21
Dust induces lung fibrosis through dysregulated DNA methylation. 38
30815999 2019
22
Sensors for detecting pulmonary diseases from exhaled breath. 38
31243097 2019
23
[Association between polymorphisms of interleukin-17 genes and pneumoconiosis susceptibility]. 38
31256521 2019
24
[Preliminary study of exon sequence in pneumoconiosis using high-throughput and intervention of EGFR-TKIs on silicosis rats]. 38
31256520 2019
25
Role of Nephronectin in Pathophysiology of Silicosis. 38
31130697 2019
26
Autophagy-Related 5 Gene rs510432 Polymorphism Is Associated with Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Virus Infection. 38
30907204 2019
27
Dusting off the numbers of in situ particle analysis: a 35-year experience. 38
31113286 2019
28
TNF-α-TNFR signal pathway inhibits autophagy and promotes apoptosis of alveolar macrophages in coal worker's pneumoconiosis. 38
30467847 2019
29
[Comprehensive rehabilitation of individualized exercise program for coal workers pneumoconiosis in Huaibei Coal Mine Group]. 38
31177714 2019
30
Treatment status and safety of crizotinib in 2028 Japanese patients with ALK-positive NSCLC in clinical settings. 38
31008509 2019
31
[Analysis of occurrence characteristics and influencing factors of new occupational diseases in Tianjin city from 2008 to 2017]. 38
31177689 2019
32
[Analysis on the monitoring results of occupational health of workers who leaving their posts from small-sized coal mines]. 38
31177696 2019
33
The health and social implications of household air pollution and respiratory diseases. 38
31028270 2019
34
[Epidemiological analysis of 1494 cases of pneumoconiosis in a city]. 38
31177698 2019
35
[Research of epigenetic modifications in pathogenesis of pneumoconiosis]. 38
31177705 2019
36
Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study. 38
30674606 2019
37
Pneumoconiosises: modern view. 38
31094468 2019
38
[Analysis of new occupational diseases in Hengyang from 2006 to 2017]. 38
31189240 2019
39
Achievements, Problems, and Future Direction of the Quality Control Program for Special Periodic Health Examination Agencies in Republic of Korea. 38
30949392 2019
40
[Investigation of medication compliance in patients with pneumoconiosis complicated with chronic obstructive pulmonary disease at stable stage]. 38
31189243 2019
41
Prevalence of Arthritis and Rheumatoid Arthritis in Coal Mining Counties of the United States. 38
30875457 2019
42
[Clinical study on traditional Chinese medicine syndrome differentiation and treatment of pneumoconiosis]. 38
31189238 2019
43
[Analysis of occupational pneumoconiosis in Jiangsu province from 2006 to 2017]. 38
31189239 2019
44
[The problemand discussion for the identification of a case of occupational pneumoconiosis]. 38
31189248 2019
45
[Analysis of the causes of inconsistent diagnosis and Identification of two cases of occupational coal workers' pneumoconiosis]. 38
31189247 2019
46
Risk factors for developing Mycobacterium kansasii lung disease: A case-control study in Korea. 38
30702593 2019
47
[Prevalence of silicosis among Xiangyu railway construction workers in Nanchong from 2008-2007]. 38
30929351 2019
48
Combined effect of coal dust exposure and smoking on the prevalence of respiratory impairment among coal miners of West Bengal, India. 38
30706770 2019
49
[A case of dental technician pneumoconiosis]. 38
30929361 2019
50
Characteristics and Trends of Pneumoconiosis in the Jiangsu Province, China, 2006⁻2017. 38
30717363 2019

Variations for Pneumoconiosis

Expression for Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for Pneumoconiosis

Pathways related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 TNF TGFB1 SERPINA1 NLRP3 IL6 IL1B
2
Show member pathways
13.92 TNF TGFB1 IL6 IL1B FN1 FASLG
3
Show member pathways
13.74 TNF TGFB1 IL6 IL1B FASLG FAS
4
Show member pathways
13.61 TNF TGFB1 SOD1 IL6 IL1B FASLG
5
Show member pathways
13.47 TNF TGFB1 IL6 IL1B FASLG FAS
6
Show member pathways
13.41 TNF TGFB1 IL6 IL1B FN1 FASLG
7
Show member pathways
13.36 TNF TGFB1 IL6 IL1B FASLG FAS
8
Show member pathways
13.06 TNF IL6 FN1 FASLG FAS CASP8
9
Show member pathways
13.02 TNF IL6 FN1 FASLG FAS CCL2
10
Show member pathways
13 TNF TGFB1 IL6 IL1B FASLG FAS
11
Show member pathways
13 TNF TGFB1 NLRP3 IL6 IL1B FASLG
12
Show member pathways
12.9 TNF TGFB1 IL6 IL1B HSPA1L FASLG
13 12.89 TGFB1 IL6 GSTM1 FN1 FASLG FAS
14 12.84 TNF TGFB1 IL1B HSPA1L FASLG FAS
15
Show member pathways
12.82 TNF IL6 IL1B CXCL8 CASP8
16
Show member pathways
12.75 TNF IL1B FASLG FAS CASP8
17
Show member pathways
12.7 TNF IL1B FN1 FASLG FAS CASP8
18
Show member pathways
12.66 TNF FASLG FAS CASP8
19
Show member pathways
12.66 TNF IL6 IL1B FN1 CCL2
20 12.64 TNF IL1B FASLG FAS CCL2
21
Show member pathways
12.63 TNF TGFB1 IL6 IL1B FAS
22
Show member pathways
12.43 TNF SOD1 IL6 IL1B CCL2 CAT
23
Show member pathways
12.43 TNF IL6 IL1B CXCL8 CCL2 CASP8
24
Show member pathways
12.39 TNF FASLG FAS CASP8
25 12.39 TNF TGFB1 FN1 FASLG FAS
26
Show member pathways
12.36 TNF IL6 IL1B CXCL8
27
Show member pathways
12.34 TNF TGFB1 IL6 IL1B CXCL8
28
Show member pathways
12.34 TNF TGFB1 IL1B HSPA1L CASP8
29
Show member pathways
12.32 TNF FASLG FAS CASP8
30 12.32 TNF FASLG FAS CASP8
31 12.32 TNF TGFB1 IL6 IL1B CASP8
32
Show member pathways
12.31 TNF IL6 IL1B CXCL8 CP
33
Show member pathways
12.3 TNF NLRP3 IL6 IL1B CASP8
34
Show member pathways
12.3 TNF NLRP3 IL1B FASLG FAS CASP8
35 12.25 TNF IL6 IL1B CXCL8
36 12.17 TNF IL1B GSTM1 CCL2
37
Show member pathways
12.17 TNF IL6 IL1B FN1 FASLG FAS
38
Show member pathways
12.16 TGFB1 IL6 FASLG CAT
39
Show member pathways
12.15 TGFB1 IL6 IL1B CXCL8 CCL2
40 12.14 TNF TGFB1 IL6 FAS
41
Show member pathways
12.14 TNF SOD1 IL6 IL1B FN1
42
Show member pathways
12.13 TNF TGFB1 IL6 IL1B
43 12.08 TNF TGFB1 IL6 IL1B CXCL8 CCL2
44 12.05 TGFB1 IL6 IL1B FN1 CXCL8
45 12.02 TNF IL6 IL1B FAS CCL2 CASP8
46 11.96 TNF TGFB1 IL6 IL1B FN1 CXCL8
47 11.95 TNF IL1B CXCL8
48 11.93 TNF IL6 IL1B
49
Show member pathways
11.91 TGFB1 IL6 CXCL8
50 11.88 TNF NLRP3 IL6 IL1B CXCL8

GO Terms for Pneumoconiosis

Cellular components related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.73 SERPINA1 IL6 FN1 CP
2 extracellular space GO:0005615 9.73 TNF TGFB1 SOD1 SERPINA1 IL6 IL1B
3 membrane raft GO:0045121 9.71 TNF FASLG FAS CASP8
4 secretory granule GO:0030141 9.65 TGFB1 SOD1 IL1B
5 platelet alpha granule lumen GO:0031093 9.54 TGFB1 SERPINA1 FN1
6 extracellular region GO:0005576 9.47 TNF TGFB1 SOD1 SERPINA1 NLRP3 IL6
7 blood microparticle GO:0072562 9.46 TGFB1 HSPA1L FN1 CP
8 death-inducing signaling complex GO:0031264 9.32 FAS CASP8
9 CD95 death-inducing signaling complex GO:0031265 9.26 FAS CASP8
10 extracellular exosome GO:0070062 10.06 SOD1 SERPINA1 IL1B FN1 FASLG FAS

Biological processes related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.99 SERPINA1 IL6 FN1 CP
2 leukocyte migration GO:0050900 9.98 TNF TGFB1 IL1B FN1
3 positive regulation of protein phosphorylation GO:0001934 9.97 TNF TGFB1 IL1B FAS
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 TNF IL1B FASLG CASP8
5 inflammatory response GO:0006954 9.95 TNF TGFB1 NLRP3 IL6 IL1B CXCL8
6 platelet degranulation GO:0002576 9.91 TGFB1 SOD1 SERPINA1 FN1
7 defense response to Gram-positive bacterium GO:0050830 9.9 TNF NLRP3 IL6
8 response to organic substance GO:0010033 9.89 TNF TGFB1 SOD1
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.89 TNF TGFB1 IL6
10 neutrophil chemotaxis GO:0030593 9.88 IL1B CXCL8 CCL2
11 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 TNF TGFB1 CCL2
12 cellular response to mechanical stimulus GO:0071260 9.87 TGFB1 IL1B FAS CASP8
13 positive regulation of interleukin-6 production GO:0032755 9.86 TNF IL6 IL1B
14 humoral immune response GO:0006959 9.85 TNF IL6 CCL2
15 apoptotic signaling pathway GO:0097190 9.84 TNF FASLG FAS CASP8
16 negative regulation of fat cell differentiation GO:0045599 9.82 TNF TGFB1 IL6
17 positive regulation of cell division GO:0051781 9.82 TGFB1 IL1B CAT
18 acute-phase response GO:0006953 9.8 SERPINA1 IL6 FN1
19 protein kinase B signaling GO:0043491 9.8 TNF TGFB1 IL1B CCL2
20 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.79 FASLG FAS CASP8
21 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.77 TNF FASLG CASP8
22 response to ethanol GO:0045471 9.77 SOD1 CAT CASP8
23 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.77 TNF NLRP3 FASLG FAS CASP8
24 response to estradiol GO:0032355 9.76 TGFB1 CAT CASP8
25 negative regulation of neurogenesis GO:0050768 9.75 TNF IL6 IL1B
26 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.73 FASLG FAS CASP8
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 TNF TGFB1 IL1B CCL2
28 cellular response to lipopolysaccharide GO:0071222 9.73 TNF NLRP3 IL6 IL1B CXCL8 CCL2
29 wound healing GO:0042060 9.72 TGFB1 FN1
30 response to reactive oxygen species GO:0000302 9.72 SOD1 CAT
31 positive regulation of glial cell proliferation GO:0060252 9.72 TNF IL6 IL1B
32 cellular response to organic cyclic compound GO:0071407 9.72 TNF TGFB1 IL1B CCL2 CASP8
33 PERK-mediated unfolded protein response GO:0036499 9.71 CXCL8 CCL2
34 negative regulation of lipid storage GO:0010888 9.7 TNF IL6
35 positive regulation of chemokine biosynthetic process GO:0045080 9.7 TNF IL1B
36 death-inducing signaling complex assembly GO:0071550 9.7 TNF CASP8
37 response to glucocorticoid GO:0051384 9.69 TNF IL6
38 regulation of establishment of endothelial barrier GO:1903140 9.69 TNF IL1B
39 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.67 NLRP3 IL6
40 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
41 interleukin-1 beta production GO:0032611 9.65 NLRP3 IL1B
42 positive regulation of neuroinflammatory response GO:0150078 9.65 TNF IL6 IL1B
43 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
44 necroptotic signaling pathway GO:0097527 9.63 TNF FASLG FAS
45 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.63 TNF TGFB1 NLRP3 IL6 IL1B CAT
46 positive regulation of mononuclear cell migration GO:0071677 9.62 TNF TGFB1
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 TNF IL1B
48 response to ozone GO:0010193 9.36 CAT
49 response to L-ascorbic acid GO:0033591 9.36 CAT
50 extrinsic apoptotic signaling pathway GO:0097191 9.35 TNF TGFB1 FASLG FAS CASP8

Molecular functions related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.65 TGFB1 SOD1 GSTM1 FN1 CAT
2 identical protein binding GO:0042802 9.61 TNF TGFB1 SOD1 SERPINA1 NLRP3 FN1
3 chaperone binding GO:0051087 9.54 SOD1 FN1 CP
4 protease binding GO:0002020 9.5 TNF SERPINA1 FN1
5 tumor necrosis factor receptor binding GO:0005164 9.33 TNF FASLG CASP8
6 cytokine activity GO:0005125 9.17 TNF TGFB1 IL6 IL1B FASLG CXCL8

Sources for Pneumoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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