MCID: PNM006
MIFTS: 56

Pneumoconiosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Pneumoconiosis

MalaCards integrated aliases for Pneumoconiosis:

Name: Pneumoconiosis 12 74 58 54 43 15 71

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

Disease Ontology 12 DOID:10316
ICD9CM 34 505
MeSH 43 D011009
NCIt 49 C26861
SNOMED-CT 67 40122008
MESH via Orphanet 44 D011009
UMLS via Orphanet 72 C0032273
Orphanet 58 ORPHA182098
UMLS 71 C0032273

Summaries for Pneumoconiosis

Disease Ontology : 12 An interstitial lung disease that is caused by the inhalation of dust.

MalaCards based summary : Pneumoconiosis is related to anthracosis and asbestosis. An important gene associated with Pneumoconiosis is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Amlodipine and Metoprolol have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Pneumoconiosis is the general term for a class of interstitial lung diseases where inhalation of dust... more...

Related Diseases for Pneumoconiosis

Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 739)
# Related Disease Score Top Affiliating Genes
1 anthracosis 34.8 TNF TGFB1 IL1B CCL2
2 asbestosis 33.0 SERPINA1 NLRP3 IL6 IL1B GSTM1 CAT
3 silicosis 32.6 TNF TGFB1 NLRP3 IL4 IL1RN IL1B
4 anthracosilicosis 32.1 IL1B CP
5 pulmonary fibrosis 31.9 TGFB1 IL1B CXCL8 CCL2
6 sarcoidosis 1 31.0 TNF IL1RN IL1B IL1A CCL2
7 pleural disease 30.9 TNF IL6 IL1B CXCL8
8 mycobacterium tuberculosis 1 30.9 TNF SERPINA1 IL4 IL10 FN1
9 arteries, anomalies of 30.9 TNF IL6 IL1B CCL2
10 pulmonary tuberculosis 30.9 TNF IL6 IL4 IL1B IL10 CP
11 bronchitis 30.8 TNF SERPINA1 IL6 IL4 IL1B IL10
12 pulmonary alveolar proteinosis 30.8 TNF IL6 IL10 CXCL8 CCL2
13 bronchiectasis 30.8 TNF SERPINA1 IL1B CXCL8
14 congestive heart failure 30.7 TNF IL6 IL1B FN1
15 haemophilus influenzae 30.7 TNF CXCL8
16 pleural tuberculosis 30.6 TNF CXCL8 CCL2
17 pleurisy 30.6 TNF TGFB1 IL1RN CXCL8 CCL2
18 respiratory failure 30.6 TNF SOD1 SERPINA1 IL6 IL1RN IL1B
19 lipoprotein quantitative trait locus 30.6 TNF IL6 IL1RN IL1B IL10 CXCL8
20 echinococcosis 30.5 TNF IL6 IL10
21 pancreatitis 30.5 TNF IL6 IL1B IL10
22 mycobacterium kansasii 30.5 NLRP3 FN1 CXCL8
23 pulmonary edema 30.5 TNF IL1B IL10 FASLG CXCL8
24 eosinophilic pneumonia 30.4 IL6 IL4 CXCL8
25 aspergillosis 30.4 TNF IL6 IL4 IL1RN IL1B IL1A
26 pericarditis 30.4 TNF IL6 IL1RN IL1B CXCL8
27 interstitial lung disease 30.4 TNF TGFB1 IL6 IL4 IL1B IL1A
28 pulmonary hypertension 30.4 TNF IL6 IL1B IL10 FN1 CXCL8
29 cryptococcosis 30.4 TNF IL4 IL10
30 peptic ulcer disease 30.4 TNF IL1RN IL1B IL10 CXCL8 CAT
31 bronchopneumonia 30.3 TNF IL6 IL1B IL10 CXCL8
32 bronchiolitis obliterans 30.3 TNF TGFB1 IL6 IL10 CXCL8
33 lung disease 30.3 TNF TGFB1 SOD1 SERPINA1 IL6 IL4
34 pulmonary eosinophilia 30.3 SERPINA1 IL4 CXCL8
35 systemic scleroderma 30.3 TNF TGFB1 IL6 IL4 IL1B IL10
36 severe acute respiratory syndrome 30.3 TNF IL6 IL10 CXCL8 CCL2
37 extrinsic allergic alveolitis 30.3 SOD1 IL6 IL1B IL1A IL10 FN1
38 pulmonary disease, chronic obstructive 30.2 TNF TGFB1 SERPINA1 IL6 IL4 IL1B
39 allergic hypersensitivity disease 30.2 TNF IL4 IL10 CXCL8
40 cellulitis 30.2 TNF IL6 IL4 IL1B IL10
41 gout 30.2 TNF NLRP3 IL6 IL1B CXCL8 CCL2
42 vasculitis 30.2 TNF SERPINA1 IL6 IL10 CCL2
43 sleep apnea 30.2 TNF IL6 IL1B IL10 CXCL8 CCL2
44 endocarditis 30.1 TNF IL6 IL1A IL10 CXCL8 CAT
45 paranasal sinus disease 30.1 TNF TGFB1 IL6 IL4 IL10 CXCL8
46 connective tissue disease 30.1 TNF IL6 IL4 IL1B IL1A IL10
47 arthritis 29.9 TNF TGFB1 IL6 IL4 IL1RN IL1B
48 heart disease 29.9 TNF TGFB1 IL6 IL1RN IL1B IL10
49 esophagitis 29.9 TNF TGFB1 IL6 IL4 IL1B IL10
50 bronchiolitis 29.8 TNF IL6 IL4 IL1A IL10 CXCL8

Comorbidity relations with Pneumoconiosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Familial Atrial Fibrillation Heart Disease
Postinflammatory Pulmonary Fibrosis Prostatic Hypertrophy
Respiratory Failure

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to Pneumoconiosis

Symptoms & Phenotypes for Pneumoconiosis

GenomeRNAi Phenotypes related to Pneumoconiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 CASP8
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 CASP8 FASLG IL10 IL1A IL1B NLRP3
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.7 CASP8 IL1A SOD1
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 CXCL8 IL10 IL1A IL1B NLRP3 SOD1
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 CXCL8 IL10 IL1B NLRP3 SOD1 TGFB1
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.53 CASP8

MGI Mouse Phenotypes related to Pneumoconiosis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 CASP8 CAT CP FASLG FN1 IL10
2 hematopoietic system MP:0005397 10.32 CASP8 CP FASLG FN1 IL10 IL1A
3 cellular MP:0005384 10.31 CASP8 CAT CP FASLG FN1 IL10
4 immune system MP:0005387 10.31 CASP8 CCL2 CP FASLG FN1 IL10
5 cardiovascular system MP:0005385 10.29 CASP8 CP FASLG FN1 IL10 IL1A
6 integument MP:0010771 10.22 CASP8 FASLG FN1 IL10 IL1A IL1B
7 mortality/aging MP:0010768 10.17 CASP8 CAT FASLG FN1 IL10 IL1B
8 liver/biliary system MP:0005370 10.11 CASP8 CP FASLG FN1 IL10 IL4
9 neoplasm MP:0002006 10 CASP8 CAT FASLG FN1 IL10 IL1A
10 nervous system MP:0003631 9.93 CASP8 CP FASLG FN1 IL10 IL1B
11 reproductive system MP:0005389 9.65 FASLG FN1 IL10 IL1RN IL4 IL6
12 skeleton MP:0005390 9.36 FASLG FN1 IL10 IL1B IL1RN IL4

Drugs & Therapeutics for Pneumoconiosis

Drugs for Pneumoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
2
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
3 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
4 Antihypertensive Agents Phase 2, Phase 3
5 Hormones Phase 2, Phase 3
6 Adrenergic Agents Phase 2, Phase 3
7 Adrenergic Antagonists Phase 2, Phase 3
8 Anti-Arrhythmia Agents Phase 2, Phase 3
9 Vasodilator Agents Phase 2, Phase 3
10 Adrenergic beta-Antagonists Phase 2, Phase 3
11 Sympatholytics Phase 2, Phase 3
12 Calcium, Dietary Phase 2, Phase 3
13 Neurotransmitter Agents Phase 2, Phase 3
14 calcium channel blockers Phase 2, Phase 3
15
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
16
Nintedanib Approved Phase 2 656247-17-5 56843413
17
Cocaine Approved, Illicit 50-36-2 446220 5760

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 The Study Was Approved by the Ethics Committee of Our Institution, Which is Accredited by the Office of Human Research Protection as an Institutional Review Board Unknown status NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
2 The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial Not yet recruiting NCT04161014 Phase 2 Nintedanib 150 MG [Ofev]
3 A Phase I Study of Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Unknown status NCT02790762 Phase 1
4 A Multicenter, Randomized, Single-blind, Parallel-group Study of Combined Large Volume WLL With Clinical Grade Umbilical Cord Mesenchymal Stem Cells(MSC) Transplantation for Treatment of Pneumoconiosis Completed NCT02668068 Phase 1
5 Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed in Patients With Emphysema and Interstitial Fibrosis Compared to Non-diseased Areas Unknown status NCT02705144
6 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
7 Palliative Care Coaching for Family Caregivers & Patients With Rare Advanced Lung Disease Completed NCT03813667
8 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
9 The Experience of Patients and Family Caregivers in Managing Pneumoconiosis in the Family Context: An Exploratory Qualitative Study Recruiting NCT04022902
10 Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma Recruiting NCT04205708
11 DNA Methylation Analysis to Identify Functional Epigenetic Marks in Acute Coronary Syndrome and Atrial Fibrillation Recruiting NCT04371809

Search NIH Clinical Center for Pneumoconiosis

Cochrane evidence based reviews: pneumoconiosis

Genetic Tests for Pneumoconiosis

Anatomical Context for Pneumoconiosis

MalaCards organs/tissues related to Pneumoconiosis:

40
Lung, Testes, Heart, Lymph Node, Liver, Neutrophil, Bone

Publications for Pneumoconiosis

Articles related to Pneumoconiosis:

(show top 50) (show all 4132)
# Title Authors PMID Year
1
[Regulation role of superoxide dismutase coenzyme on Fas/FasL signal transduction and apoptosis in alveolar macrophages of pneumoconiosis patients]. 54 61
18727868 2008
2
[Activity of superoxide dismutase and level of lipid peroxidation in pneumoconiosis patients]. 61 54
17908436 2007
3
[Significance of serum sialic acid and ceruloplasmin in early lung fibrosis of pneumoconiosis]. 61 54
16600124 2006
4
[Free radial activity in patients with pneumoconioses]. 54 61
8629354 1996
5
Blood antioxidant enzymes as markers of exposure or effect in coal miners. 54 61
8563856 1996
6
Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. 61
32526187 2020
7
Trends in Pneumoconiosis Deaths - United States, 1999-2018. 61
32525855 2020
8
Magnetic targeting increases mesenchymal stromal cell retention in lungs and enhances beneficial effects on pulmonary damage in experimental silicosis. 61
32538526 2020
9
[Level and trend of respiratory diseases mortality in China from 2002 to 2016]. 61
32575935 2020
10
Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017. 61
32188634 2020
11
Eye Tracking to Evaluate the Usability of an Online Pneumoconiosis Education Booklet in a Sample of South Asian Construction Workers. 61
32541364 2020
12
Estimating the prevalence and spatial clusters of coal workers' pneumoconiosis cases using medicare claims data, 2011-2014. 61
32147857 2020
13
Pneumoconiosis progression patterns in US coal miner participants of a job transfer programme designed to prevent progression of disease. 61
32169972 2020
14
[Study on clinical phenotype of coal workers pneumoconiosis]. 61
32536078 2020
15
Increased risk of gastric cancer in workers with occupational dust exposure. 61
32375207 2020
16
Potential of deep learning in assessing pneumoconiosis depicted on digital chest radiography. 61
32471837 2020
17
A new era of coal workers' pneumoconiosis: decades in mines may not be required. 61
32359461 2020
18
[Serum metabolomics in latent pneumoconiosis tuberculosis patients based on ultra performance liquid chromatography tandem quadrupole time of flight mass spectrometry]. 61
32447884 2020
19
[Analysis of the burden of coal worker's pneumoconiosis disease in a mining group]. 61
32447893 2020
20
What does coal mine dust lung disease look like? A radiological review following re-identification in Queensland. 61
32048474 2020
21
Association of Silica Dust Exposure and Cigarette Smoking With Mortality Among Mine and Pottery Workers in China. 61
32286660 2020
22
Self-management of oxygen and bronchodilators to relieve the dyspnoea of lung cancer with pneumoconiosis. 61
32378485 2020
23
[Follow-up and retrospective investigation of patients with pneumoconiosis in Jiangsu Province, China]. 61
32447885 2020
24
Prevalence of spirometry-defined airflow obstruction in never-smoking working US coal miners by pneumoconiosis status. 61
32041810 2020
25
Comparison of Risk of Silicosis in Metal Mines and Pottery Factories: A 44-Year Cohort Study. 61
32298729 2020
26
Silicosis in finishing workers in quartz conglomerates processing. 61
32352423 2020
27
NAF1 rs4691896 Is Significantly Associated with Coal Workers' Pneumoconiosis in a Chinese Han Population: A Case-Control Study. 61
32333749 2020
28
[Progress in study on intervention of silica-induced pulmonary fibrosis with the exosomes released from mesenchymal stem cells]. 61
32447901 2020
29
Autophagy, an important therapeutic target for pulmonary fibrosis diseases. 61
31877297 2020
30
Intra-pleural Instillation of Autologous Blood - Fine-tuning Techniques for Better Success Rate: Two Case Reports. 61
32281606 2020
31
[Diagnostic Challenges of Mixed Dust Silicosis (Mixed Dust Pneumoconiosis) - 5 Case Reports]. 61
32052391 2020
32
Editorial: Timely topical reviews on climate change, indoor air pollution, coalworkers' pneumoconiosis, and chronic obstructive pulmonary disease. 61
31904625 2020
33
[Analysis of other diseases misdiagnosed as pneumoconiosis]. 61
32306696 2020
34
Pneumoconiosis ICD-CM Diagnosis Codes on Medicare Claims for Federal Black Lung Program Beneficiaries. 61
32182100 2020
35
Spatial and Temporal Variations of Pneumoconiosis in the Pearl River Delta Region in 2006-2015. 61
32209178 2020
36
[Meta-analysis on association between interleukin-6-174C/G and -634C/G polymorphisms and pneumoconiosis susceptibility]. 61
32290930 2020
37
Associations of HMGB1 gene polymorphisms with risk of coal workers' pneumoconiosis susceptibility in Chinese Han population. 61
32408780 2020
38
[The characteristics of spatial-temporal evolvement of pneumoconiosis in Hebei Province from 2009 to 2018]. 61
32306689 2020
39
Respiratory surveillance in mineral dust-exposed workers. 61
32194772 2020
40
Global and regional burden of chronic respiratory disease in 2016 arising from non-infectious airborne occupational exposures: a systematic analysis for the Global Burden of Disease Study 2016. 61
32054818 2020
41
Assessment of silica dust exposure profile in relation to prevalence of silicosis among Indian sandstone mine workers: Need for review of standards. 61
31773774 2020
42
[Systems and actual practices of occupational safety and health risk management in the People's Republic of China]. 61
31474689 2020
43
[Diagnostic value of heparin-binding protein in patients with silicosis complicated by severe infection]. 61
32306695 2020
44
Respirable coal mine dust at surface mines, United States, 1982-2017. 61
31820465 2020
45
Coal mining and lung disease in the 21st century. 61
31815751 2020
46
CT/NIRF dual-modal imaging tracking and therapeutic efficacy of transplanted mesenchymal stem cells labeled with Au nanoparticles in silica-induced pulmonary fibrosis. 61
32022096 2020
47
Trends and risk factors of mortality and disability adjusted life years for chronic respiratory diseases from 1990 to 2017: systematic analysis for the Global Burden of Disease Study 2017. 61
32075787 2020
48
Trends in prevalence and incidence of chronic respiratory diseases from 1990 to 2017. 61
32046720 2020
49
Pneumoconiosis Caused by Inhalation of Metallic Titanium Grindings. 61
31645530 2020
50
A thermogravimetric analysis application to determine coal, carbonate, and non-carbonate minerals mass fractions in respirable mine dust. 61
31868573 2020

Variations for Pneumoconiosis

Expression for Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for Pneumoconiosis

Pathways related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 TNF TGFB1 SERPINA1 NLRP3 IL6 IL4
2
Show member pathways
13.96 TNF TGFB1 IL6 IL4 IL1B IL1A
3
Show member pathways
13.81 TNF TGFB1 IL6 IL4 IL1RN IL1B
4
Show member pathways
13.64 TNF TGFB1 IL6 IL4 IL1B IL1A
5
Show member pathways
13.56 TNF TGFB1 IL6 IL4 IL1B IL1A
6
Show member pathways
13.43 TNF TGFB1 IL6 IL4 IL1B IL1A
7
Show member pathways
13.42 TNF TGFB1 IL6 IL4 IL1RN IL1B
8
Show member pathways
13.4 TNF TGFB1 IL6 IL1B IL1A FASLG
9
Show member pathways
13.21 TNF TGFB1 IL6 IL1B IL10 FASLG
10
Show member pathways
13.07 TNF IL6 IL4 FN1 FASLG CASP8
11
Show member pathways
13.06 TNF IL6 IL1B FASLG CXCL8 CCL2
12 13.01 TGFB1 IL6 IL4 GSTM1 FN1 FASLG
13
Show member pathways
12.96 TNF TGFB1 IL6 IL4 IL1B IL1A
14
Show member pathways
12.94 TNF NLRP3 IL6 IL1B IL1A FASLG
15 12.91 TNF IL6 IL1B FASLG CCL2 CASP8
16
Show member pathways
12.89 TNF NLRP3 IL6 IL1RN IL1B IL1A
17 12.88 TNF TGFB1 IL1B IL1A FASLG CASP8
18
Show member pathways
12.78 TNF TGFB1 IL6 IL1B IL1A
19
Show member pathways
12.78 TNF TGFB1 IL6 IL4 IL1B IL1A
20
Show member pathways
12.77 TNF TGFB1 IL6 IL4 IL1B IL1A
21 12.74 TNF IL4 IL1RN IL1B IL10 FASLG
22
Show member pathways
12.73 TNF IL6 IL1B IL10 FN1 CCL2
23
Show member pathways
12.68 TNF IL1B IL1A FASLG CASP8
24
Show member pathways
12.52 TNF IL6 IL4 IL1B CXCL8 CCL2
25
Show member pathways
12.51 TNF SOD1 IL6 IL4 IL1B CCL2
26 12.49 TNF NLRP3 IL6 IL1B CXCL8 CASP8
27 12.46 TNF NLRP3 IL1B CXCL8
28
Show member pathways
12.46 TNF IL6 IL10 CXCL8 CCL2
29
Show member pathways
12.43 TNF IL6 IL1B IL1A CXCL8
30
Show member pathways
12.43 TNF TGFB1 IL6 IL4 IL1B IL1A
31 12.43 TNF NLRP3 IL6 IL1B FASLG CXCL8
32
Show member pathways
12.42 TNF TGFB1 IL4 IL1B IL1A IL10
33
Show member pathways
12.4 TNF NLRP3 IL6 IL1B IL10 CASP8
34 12.39 TNF NLRP3 IL6 IL1B CXCL8 CCL2
35 12.38 TNF TGFB1 FN1 FASLG
36
Show member pathways
12.38 IL1RN IL1B IL1A CCL2
37
Show member pathways
12.38 TNF NLRP3 IL1B IL1A FASLG CASP8
38 12.37 TNF TGFB1 IL6 IL1B IL1A IL10
39
Show member pathways
12.34 TNF IL6 IL1A CXCL8
40
Show member pathways
12.32 TNF IL6 IL4 IL1B FN1 FASLG
41
Show member pathways
12.31 TNF IL1A FASLG CASP8
42 12.3 TNF IL6 IL1RN IL1B IL1A IL10
43 12.26 TNF IL1B IL1A GSTM1 CCL2
44 12.25 TGFB1 IL6 IL1A CXCL8
45
Show member pathways
12.25 TGFB1 IL6 IL10 FASLG CAT
46 12.16 TNF TGFB1 IL1B IL1A
47 12.16 TNF IL6 IL1B CCL2 CASP8
48 12.14 TGFB1 IL6 IL1B IL1A FN1 CXCL8
49
Show member pathways
12.13 TNF TGFB1 IL6 IL1B IL10
50 12.11 TNF IL6 IL4 IL10

GO Terms for Pneumoconiosis

Cellular components related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 TNF TGFB1 SOD1 SERPINA1 NLRP3 IL6
2 extracellular space GO:0005615 9.53 TNF TGFB1 SOD1 SERPINA1 IL6 IL4
3 platelet alpha granule lumen GO:0031093 9.33 TGFB1 SERPINA1 FN1

Biological processes related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.3 TGFB1 NLRP3 IL6 IL4 IL1RN IL1B
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.23 TNF TGFB1 NLRP3 IL6 IL4 IL1B
3 positive regulation of transcription, DNA-templated GO:0045893 10.18 TNF TGFB1 IL6 IL4 IL1B IL10
4 positive regulation of cell proliferation GO:0008284 10.15 TGFB1 IL6 IL4 IL1B FN1 FASLG
5 positive regulation of apoptotic process GO:0043065 10.12 TNF TGFB1 SOD1 IL6 FASLG
6 negative regulation of cell proliferation GO:0008285 10.09 TGFB1 IL6 IL1B IL1A IL10 CXCL8
7 positive regulation of gene expression GO:0010628 10.07 TNF TGFB1 IL6 IL4 IL1B IL1A
8 cellular protein metabolic process GO:0044267 10.05 SERPINA1 IL6 FN1 CP
9 leukocyte migration GO:0050900 10.04 TNF TGFB1 IL1B FN1
10 aging GO:0007568 10.03 TGFB1 SOD1 IL10 CAT
11 response to lipopolysaccharide GO:0032496 10.02 IL1B IL10 FASLG CASP8
12 negative regulation of inflammatory response GO:0050728 9.99 SOD1 NLRP3 IL4 IL10
13 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 TNF IL1B IL1A FASLG CASP8
14 platelet degranulation GO:0002576 9.95 TGFB1 SOD1 SERPINA1 FN1
15 neutrophil chemotaxis GO:0030593 9.93 IL1B CXCL8 CCL2
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.93 TNF IL6 IL4
17 positive regulation of DNA-binding transcription factor activity GO:0051091 9.93 TNF IL6 IL1B IL10
18 apoptotic signaling pathway GO:0097190 9.92 TNF FASLG CASP8
19 positive regulation of T cell proliferation GO:0042102 9.92 IL6 IL4 IL1B
20 humoral immune response GO:0006959 9.91 TNF IL6 CCL2
21 inflammatory response GO:0006954 9.91 TNF TGFB1 NLRP3 IL6 IL1RN IL1B
22 positive regulation of interleukin-6 production GO:0032755 9.9 TNF IL6 IL1B
23 response to organic substance GO:0010033 9.9 TNF TGFB1 SOD1 IL10
24 negative regulation of fat cell differentiation GO:0045599 9.89 TNF TGFB1 IL6
25 T cell activation GO:0042110 9.89 TGFB1 IL4 CASP8
26 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.89 TNF NLRP3 FASLG CASP8
27 positive regulation of phagocytosis GO:0050766 9.88 TNF SOD1 IL1B
28 positive regulation of epithelial to mesenchymal transition GO:0010718 9.88 TGFB1 IL6 IL1B
29 positive regulation of interleukin-6 secretion GO:2000778 9.88 TNF IL1B IL1A
30 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.87 TNF TGFB1 IL10
31 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.86 TNF IL1B IL1A
32 negative regulation of mitotic cell cycle GO:0045930 9.86 TNF TGFB1 IL10
33 response to glucocorticoid GO:0051384 9.86 TNF IL6 IL1RN IL10
34 acute-phase response GO:0006953 9.85 SERPINA1 IL6 FN1
35 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.85 IL4 IL1B IL1A
36 immune response GO:0006955 9.85 TNF IL6 IL4 IL1RN IL1B IL1A
37 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.83 TNF FASLG CASP8
38 positive regulation of cytokine secretion GO:0050715 9.82 TNF IL1A IL10
39 positive regulation of JAK-STAT cascade GO:0046427 9.81 TNF IL6 IL10
40 positive regulation of cell division GO:0051781 9.81 TGFB1 IL1B IL1A CAT
41 negative regulation of neurogenesis GO:0050768 9.8 TNF IL6 IL1B
42 extrinsic apoptotic signaling pathway GO:0097191 9.8 TNF TGFB1 FASLG CASP8
43 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 TNF TGFB1 NLRP3 IL6 IL1B CAT
44 inflammatory response to antigenic stimulus GO:0002437 9.79 IL1RN IL1B IL1A
45 protein kinase B signaling GO:0043491 9.78 TNF TGFB1 IL1B CCL2
46 cellular response to organic cyclic compound GO:0071407 9.77 TNF TGFB1 IL1B CCL2 CASP8
47 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.76 TNF TGFB1
48 positive regulation of MHC class II biosynthetic process GO:0045348 9.76 IL4 IL10
49 positive regulation of glial cell proliferation GO:0060252 9.76 TNF IL6 IL1B
50 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 TNF TGFB1 IL1B CCL2

Molecular functions related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.86 TNF TGFB1 SOD1 SERPINA1 NLRP3 FN1
2 enzyme binding GO:0019899 9.77 TGFB1 SOD1 GSTM1 FN1 CAT
3 growth factor activity GO:0008083 9.62 TGFB1 IL6 IL4 IL10
4 copper ion binding GO:0005507 9.58 SOD1 IL1A CP
5 cytokine activity GO:0005125 9.36 TNF TGFB1 IL6 IL4 IL1RN IL1B
6 tumor necrosis factor receptor binding GO:0005164 9.33 TNF FASLG CASP8
7 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A

Sources for Pneumoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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