MCID: PNM006
MIFTS: 54

Pneumoconiosis

Categories: Respiratory diseases

Aliases & Classifications for Pneumoconiosis

MalaCards integrated aliases for Pneumoconiosis:

Name: Pneumoconiosis 12 76 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10316
ICD10 33 J64
ICD9CM 35 505
MeSH 44 D011009
NCIt 50 C26861
UMLS 73 C0032273

Summaries for Pneumoconiosis

Disease Ontology : 12 An interstitial lung disease that is caused by the inhalation of dust.

MalaCards based summary : Pneumoconiosis is related to endocarditis and esophagitis. An important gene associated with Pneumoconiosis is H19 (H19, Imprinted Maternally Expressed Transcript
Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers' Pneumoconiosis in a Chinese Population.
Dysfunction Pattern: Mutation), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Iron and Micronutrients have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and heart, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Pneumoconiosis is an occupational lung disease and a restrictive lung disease caused by the inhalation... more...

Related Diseases for Pneumoconiosis

Diseases in the Pneumoconiosis family:

Pneumoconiosis Due to Talc

Diseases related to Pneumoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 endocarditis 30.4 CXCL8 IL6 TNF
2 esophagitis 30.4 CXCL8 IL1B IL6
3 silicosis 30.3 CCL2 CXCL8 FAS FASLG IL1A IL1B
4 arteries, anomalies of 30.2 CCL2 IL1B IL6 TNF
5 pulmonary fibrosis 29.4 CCL2 IL1B MUC5B TGFB1
6 pulmonary disease, chronic obstructive 29.4 CCL2 CXCL8 GSTM1 IL6 TGFB1 TNF
7 arthritis 29.3 CCL2 CXCL8 IL1A IL1B IL6 TNF
8 lung disease 28.7 CCL2 CXCL8 IL1B MUC5B TGFB1 TNF
9 pneumonia 28.6 CCL2 CXCL8 IL1B IL6 MUC5B TNF
10 rheumatoid arthritis 27.7 CAT CCL2 CXCL8 H19 IL1A IL1B
11 pulmonary fibrosis, idiopathic 27.2 CCL2 CXCL8 FASLG IL1A IL1B MUC5B
12 kaolin pneumoconiosis 12.3
13 pneumoconiosis due to talc 12.2
14 anthracosis 12.1
15 graphite pneumoconiosis 12.1
16 mixed mineral dust pneumoconiosis 11.9
17 slate pneumoconiosis 11.8
18 caplan's syndrome 11.8
19 labrador lung 11.8
20 silicosiderosis 11.5
21 asbestosis 11.5
22 baritosis 11.4
23 berylliosis 11.4
24 scorpion envenomation 11.0 IL6 TNF
25 systemic onset juvenile idiopathic arthritis 10.9 IL1B TNF
26 leukomalacia 10.9 IL6 TNF
27 staphylococcal toxic shock syndrome 10.9 IL1B TNF
28 angioimmunoblastic lymphadenopathy with dysproteinemia 10.9 IL6 TNF
29 nontuberculous mycobacterial lung disease 10.9
30 autoimmune myocarditis 10.8 IL1B TNF
31 diabetic foot ulcers 10.8 IL6 TGFB1
32 posterior urethral valves 10.8 IL6 TGFB1 TNF
33 poems syndrome 10.8 IL1B IL6 TNF
34 central nervous system vasculitis 10.8 IL1B IL6 TNF
35 osteosclerotic myeloma 10.8 IL1B IL6 TNF
36 kashin-beck disease 10.8 FAS IL1B TNF
37 localized scleroderma 10.8 IL6 TGFB1 TNF
38 endometritis 10.8 IL1B IL6 TNF
39 joint disorders 10.8 IL1B IL6 TNF
40 commensal bacterial infectious disease 10.8 IL1B IL6 TNF
41 lacrimal apparatus disease 10.8 IL1B IL6 TNF
42 adult-onset still's disease 10.8 IL1B IL6 TNF
43 rheumatic heart disease 10.8 IL6 TGFB1 TNF
44 gingival disease 10.8 IL1B IL6 TGFB1
45 pericarditis 10.8 IL1B IL6 TNF
46 typhoid fever 10.8 IL1B IL6 TNF
47 spinal cord injury 10.7 IL6 TGFB1 TNF
48 lyme disease 10.7 IL1B IL6 TNF
49 erysipelas 10.7 CAT SOD1 TNF
50 carpal tunnel syndrome 10.7 IL1B IL6 TGFB1

Comorbidity relations with Pneumoconiosis via Phenotypic Disease Network (PDN):


Anthracosis Bronchitis
Chronic Myocardial Ischemia Familial Atrial Fibrillation
Heart Disease Ischemic Heart Disease
Postinflammatory Pulmonary Fibrosis Prostatic Hypertrophy
Respiratory Failure

Graphical network of the top 20 diseases related to Pneumoconiosis:



Diseases related to Pneumoconiosis

Symptoms & Phenotypes for Pneumoconiosis

GenomeRNAi Phenotypes related to Pneumoconiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.89 TNF IL1A IL1B NLRP3 CASP8 SOD1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.89 FAS TNF FASLG IL1A IL1B NLRP3
3 Reduced mammosphere formation GR00396-S 9.56 FAS FASLG GSTM1 H19 HSPA1L CCL2

MGI Mouse Phenotypes related to Pneumoconiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 IL1A CP IL1B FAS CASP8 FASLG
2 hematopoietic system MP:0005397 10.21 IL1A CP IL1B FAS CASP8 FASLG
3 cellular MP:0005384 10.2 CP FAS CASP8 FASLG CAT TNF
4 cardiovascular system MP:0005385 10.18 IL1A CP IL1B FAS CASP8 FASLG
5 immune system MP:0005387 10.18 CCL2 IL1A CP IL1B FAS IL6
6 integument MP:0010771 10.02 IL1A IL1B FAS CASP8 FASLG TNF
7 liver/biliary system MP:0005370 9.91 CP FAS CASP8 FASLG TNF NLRP3
8 neoplasm MP:0002006 9.85 IL1B FAS IL6 CASP8 FASLG CAT
9 nervous system MP:0003631 9.65 CP IL1B FAS CASP8 FASLG NLRP3
10 respiratory system MP:0005388 9.17 FAS CASP8 FASLG TNF IL6 TGFB1

Drugs & Therapeutics for Pneumoconiosis

Drugs for Pneumoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2 Micronutrients Phase 4
3 Trace Elements Phase 4
4 Liver Extracts Phase 4
5
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
6
Metoprolol Approved, Investigational Phase 2, Phase 3 37350-58-6, 51384-51-1 4171
7
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
8
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
9
Rifapentine Approved, Investigational Phase 3 61379-65-5 6323497
10 calcium channel blockers Phase 2, Phase 3
11 Adrenergic Agents Phase 2, Phase 3
12 Adrenergic Antagonists Phase 2, Phase 3
13 Adrenergic beta-1 Receptor Antagonists Phase 2, Phase 3
14 Adrenergic beta-Antagonists Phase 2, Phase 3
15 Sympatholytics Phase 2, Phase 3
16 Neurotransmitter Agents Phase 2, Phase 3
17 Anti-Arrhythmia Agents Phase 2, Phase 3
18 Vasodilator Agents Phase 2, Phase 3
19 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
20 Antihypertensive Agents Phase 2, Phase 3
21 Autonomic Agents Phase 2, Phase 3
22 Calcium, Dietary Phase 2, Phase 3
23 Vaccines Phase 3
24 Cytochrome P-450 CYP3A Inducers Phase 3
25 Nucleic Acid Synthesis Inhibitors Phase 3
26 Anti-Bacterial Agents Phase 3
27 Antibiotics, Antitubercular Phase 3
28 Hypolipidemic Agents Phase 3
29 Anti-Infective Agents Phase 3
30 Lipid Regulating Agents Phase 3
31 Antitubercular Agents Phase 3
32 Antimetabolites Phase 3
33
Infliximab Approved Phase 1, Phase 2 170277-31-3
34 Mesalamine Phase 1, Phase 2 89-57-6
35 Analgesics Phase 1, Phase 2
36 Mitogens Phase 1, Phase 2
37 Analgesics, Non-Narcotic Phase 1, Phase 2
38 Anti-Inflammatory Agents Phase 1, Phase 2
39 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
40 Antirheumatic Agents Phase 1, Phase 2,Phase 2
41 Gastrointestinal Agents Phase 1, Phase 2
42 Dermatologic Agents Phase 1, Phase 2
43
Deferiprone Approved 30652-11-0 2972
44
Heparin Approved, Investigational 9005-49-6 772 46507594
45 Respiratory System Agents
46 Chelating Agents
47 Iron Chelating Agents
48 calcium heparin
49 Pharmaceutical Solutions
50 Xenon Early Phase 1

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
2 Effects of Metoprolol and Amlodipine on Cardiac Remodeling, Arrhythmias and Blood Pressure Variation in Hypertensive Patients With Sleep Apnea Syndrome Unknown status NCT02408172 Phase 2, Phase 3 Amlodipine;metoprolol
3 Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older Completed NCT00753272 Phase 3
4 Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Recruiting NCT02430259 Phase 3 Weekly INH / RRT given by DOT
5 Safety Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis Completed NCT01977131 Phase 1, Phase 2
6 Targeting Oxidative Stress in Chronic Beryllium Disease Completed NCT01088243 Phase 1, Phase 2 Mesalamine;Placebo
7 Beryllium Infliximab Study: Clinical Interventional Trial Terminated NCT00111917 Phase 1, Phase 2 Infliximab
8 Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis Unknown status NCT02790762 Phase 1
9 Safety of Stem Cells Intrabronchial Instillation for Silicosis Completed NCT01239862 Phase 1
10 A Study on Pneumoconiosis Treated With Whole-lung Lavage Combined With Mesenchymal Stem Cells Recruiting NCT02668068 Phase 1
11 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343
12 Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01338064
13 DNA-damage Pathways in Workers Exposed to Silica (Caesar Stone) Unknown status NCT01329003
14 Assessment of Iron Deposition in Major Organs of Hemodialysis Patients Unknown status NCT01169961
15 Comprehensive Risk Assessment of People With Silicosis: A Population-based Study Completed NCT02794701
16 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
17 Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis Completed NCT01725971
18 Observational Study of Deferiprone (Ferriprox®) in the Treatment of Superficial Siderosis Completed NCT01284127
19 A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product Completed NCT00471224
20 Evaluation of Myocardial Iron Deposition in Patients of Heart Failure Using T2* MR Imaging Completed NCT02527330
21 Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis Completed NCT00560989
22 fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease? Completed NCT00868556
23 Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD) Recruiting NCT02604693
24 The Role of JAK2 in Alveolar Macrophages (AM's) in Chronic Beryllium Disease (CBD) Recruiting NCT02596347
25 Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy Active, not recruiting NCT01856699
26 Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. Not yet recruiting NCT03464344 Not Applicable
27 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6

Search NIH Clinical Center for Pneumoconiosis

Cochrane evidence based reviews: pneumoconiosis

Genetic Tests for Pneumoconiosis

Anatomical Context for Pneumoconiosis

MalaCards organs/tissues related to Pneumoconiosis:

41
Lung, Liver, Heart, Testes, Bone Marrow, Bone, Monocytes

Publications for Pneumoconiosis

Articles related to Pneumoconiosis:

(show top 50) (show all 653)
# Title Authors Year
1
Estimated economic costs of coal workers' pneumoconiosis among coal workers redeployed from the Fuxin mining group in China. ( 29116190 )
2018
2
Assessment of physicians' proficiency in reading chest radiographs for pneumoconiosis, based on a 60-film examination set with two factors constituting eight indices. ( 29806618 )
2018
3
TNFR/TNF-I+ signaling pathway regulates apoptosis of alveolar macrophages in coal workers' pneumoconiosis. ( 29416696 )
2018
4
Association analysis identifies new risk loci for coal workers' pneumoconiosis in Han Chinese men. ( 29394417 )
2018
5
Mica pneumoconiosis: a neglected occupational lung disease. ( 29759917 )
2018
6
Both-sided native valve infective endocarditis in a drug addict with incidental pneumoconiosis. ( 29704724 )
2018
7
Should hut lung be called domestically acquired particulate lung disease or domestically acquired pneumoconiosis? ( 29487788 )
2018
8
Prevalence of latent tuberculosis infection among coal workers' pneumoconiosis patients in China: a cross-sectional study. ( 29642880 )
2018
9
Establishment and application of an index system for prevention of coal workers' pneumoconiosis: a Delphi and analytic hierarchy process study in four state-owned coal enterprises of China. ( 29563194 )
2018
10
Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269. ( 29415464 )
2018
11
Prevalence and characteristics of COPD among pneumoconiosis patients at an occupational disease prevention institute: a cross-sectional study. ( 29378587 )
2018
12
Dental Technicians' Pneumoconiosis; Illness Behind a Healthy Smile - Case Series of a Reference Center in Turkey. ( 29743783 )
2018
13
WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis. ( 29958118 )
2018
14
A response to the Comment on Tomaskova et al. Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. Int. J. Environ. Res. Public Health, 2017, 14, 269 by the Author Mei Yong. ( 29438277 )
2018
15
Continued increase in lung transplantation for coal workers' pneumoconiosis in the United States. ( 29732582 )
2018
16
Daytime blood pressure surges following hypoxic episodes in a case of pneumoconiosis with lacunar stroke recurrences. ( 28263202 )
2017
17
Increasing Severity of Pneumoconiosis Among Younger Former US Coal Miners Working Exclusively Under Modern Dust-Control Regulations. ( 28598937 )
2017
18
TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis. ( 28698801 )
2017
19
Progressive massive fibrosis in patients with pneumoconiosis: utility of MRI in differentiating from lung cancer. ( 28361545 )
2017
20
Element-based prognostics of occupational pneumoconiosis using micro-proton-induced X-ray emission analysis. ( 28912379 )
2017
21
Squamous cell carcinoma of the lung showing a ground glass nodule on high-resolution computed tomography associated with pneumoconiosis: a case report. ( 28963659 )
2017
22
Mortality in Miners with Coal-Workers' Pneumoconiosis in the Czech Republic in the Period 1992-2013. ( 28272360 )
2017
23
LRBA Gene Polymorphisms and Risk of Coal Workers' Pneumoconiosis: A Case-Control Study from China. ( 28953250 )
2017
24
The association of LAMB1 polymorphism and expression changes with the risk of coal workers' pneumoconiosis. ( 28444932 )
2017
25
Survival Analysis of Coal Workers' Pneumoconiosis (CWP) Patients in a State-Owned Mine in the East of China from 1963 to 2014. ( 28481235 )
2017
26
Polymorphisms in autophagy related genes and the coal workers' pneumoconiosis in a Chinese population. ( 28844669 )
2017
27
Loss of regulatory characteristics in CD4(+) CD25(+/hi) T cells induced by impaired transforming growth factor beta secretion in pneumoconiosis. ( 28913840 )
2017
28
A case of mixed dust pneumoconiosis with desquamative interstitial pneumonia-like reaction in an aluminum welder. ( 28239542 )
2017
29
Association between Genetic Variants of Transforming Growth Factor-I^1 and Susceptibility of Pneumoconiosis: A Meta-analysis. ( 28139521 )
2017
30
Wood charcoal dust pneumoconiosis. ( 28365221 )
2017
31
Cross-section analysis of coal workers' pneumoconiosis and higher brachial-ankle pulse wave velocity within Kailuan study. ( 28148238 )
2017
32
Coal miner participation in a job transfer program designed to prevent progression of pneumoconiosis, United States, 1986-2016. ( 29116886 )
2017
33
Evaluation of dental technician's pneumoconiosis using chest X-rayand HRCT: correlation between radiological and functional findings. ( 28263498 )
2017
34
[Clinical observation of external diaphragm pacing in patients with pneumoconiosis complicated with chronic obstructive pulmonary disease in stable stage]. ( 28614935 )
2017
35
Dental Technicians' Pneumoconiosis. ( 29021460 )
2017
36
Diagnostic and clinical application value of magnetic resonance imaging (MRI) for progressive massive fibrosis of coal worker pneumoconiosis: Case reports. ( 28514304 )
2017
37
Diagnostic accuracy of breath tests for pneumoconiosis using an electronic nose. ( 28795953 )
2017
38
Development of breath test for pneumoconiosis: a case-control study. ( 29041938 )
2017
39
Dental technician pneumoconiosis mimicking pulmonary tuberculosis: a case report. ( 27604085 )
2016
40
Estimates and Predictions of Coal Workers' Pneumoconiosis Cases among Redeployed Coal Workers of the Fuxin Mining Industry Group in China: A Historical Cohort Study. ( 26845337 )
2016
41
Aluminum-induced pneumoconiosis confirmed by analytical scanning electron microscopy: A case report and review of the literature. ( 26895029 )
2016
42
Risk of Cerebrovascular Events in Pneumoconiosis Patients: A Population-based Study, 1996-2011. ( 26945404 )
2016
43
Pneumoconiosis in different sectors and their differences in Turkey. ( 28393716 )
2016
44
Risk factors associated with mortality from pneumonia among patients with pneumoconiosis. ( 27057317 )
2016
45
Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population. ( 27621877 )
2016
46
Endogenous pneumoconiosis: Analytical scanning electron microscopic analysis of a case. ( 27281119 )
2016
47
Endobronchial fibroma in a pneumoconiosis patient with a history of tuberculosis: A case report and literature review. ( 27446391 )
2016
48
Screening and Preliminary Verification of a Phage Display Single-Chain Antibody Library Against Coal Workers' Pneumoconiosis. ( 27930489 )
2016
49
Ocular findings in coal miners diagnosed with pneumoconiosis. ( 27292375 )
2016
50
Ocular findings in coal miners diagnosed with pneumoconiosis. ( 27406957 )
2016

Variations for Pneumoconiosis

Expression for Pneumoconiosis

Search GEO for disease gene expression data for Pneumoconiosis.

Pathways for Pneumoconiosis

Pathways related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 CASP8 CAT CCL2 CXCL8 FASLG IL1A
2
Show member pathways
13.92 CASP8 CCL2 CXCL8 FAS FASLG IL1A
3
Show member pathways
13.75 CASP8 CCL2 CXCL8 FAS FASLG IL1A
4
Show member pathways
13.63 CASP8 CXCL8 FAS FASLG IL1A IL1B
5
Show member pathways
13.54 CCL2 CXCL8 IL1A IL1B IL6 TGFB1
6
Show member pathways
13.49 CCL2 CXCL8 FAS FASLG IL1A IL1B
7
Show member pathways
13.43 CCL2 CXCL8 FASLG IL1A IL1B IL6
8
Show member pathways
13.37 CASP8 CCL2 CXCL8 FAS FASLG IL1A
9
Show member pathways
13.19 CAT CXCL8 HSPA1L IL1A IL6 SOD1
10
Show member pathways
13.05 CASP8 CCL2 CXCL8 FAS FASLG IL1B
11
Show member pathways
12.97 CASP8 CCL2 FAS FASLG IL6 TNF
12 12.93 CASP8 CXCL8 FAS FASLG GSTM1 IL6
13
Show member pathways
12.92 CASP8 CXCL8 FAS FASLG HSPA1L IL1A
14 12.86 CASP8 FAS FASLG HSPA1L IL1A IL1B
15
Show member pathways
12.82 CASP8 CXCL8 IL1B IL6 TNF
16
Show member pathways
12.76 IL1A IL1B IL6 TGFB1 TNF
17
Show member pathways
12.73 FAS FASLG IL1A IL1B TNF
18
Show member pathways
12.72 CXCL8 IL1A IL1B IL6 TNF
19
Show member pathways
12.68 CASP8 CXCL8 FAS FASLG IL6 TGFB1
20 12.65 CCL2 FAS FASLG IL1B TNF
21
Show member pathways
12.61 CASP8 FASLG IL1A IL1B TNF
22
Show member pathways
12.54 IL1A IL1B IL6 TGFB1 TNF
23
Show member pathways
12.54 FAS IL1A IL1B IL6 TGFB1 TNF
24
Show member pathways
12.53 CASP8 FAS FASLG TNF
25
Show member pathways
12.44 CAT CCL2 IL1B IL6 SOD1 TNF
26
Show member pathways
12.44 CASP8 CCL2 CXCL8 IL1B IL6 MUC5B
27
Show member pathways
12.39 CASP8 FAS FASLG TNF
28
Show member pathways
12.38 CXCL8 IL1A IL1B IL6 TNF
29
Show member pathways
12.38 CASP8 HSPA1L IL1A IL1B TGFB1 TNF
30 12.36 FAS FASLG TGFB1 TNF
31 12.35 CASP8 IL1A IL1B IL6 TGFB1 TNF
32
Show member pathways
12.34 CP CXCL8 IL1A IL1B IL6 MUC5B
33
Show member pathways
12.33 CXCL8 IL1A IL6 TNF
34
Show member pathways
12.32 IL1B IL6 TGFB1 TNF
35
Show member pathways
12.32 CASP8 IL1B IL6 NLRP3 TNF
36
Show member pathways
12.32 CASP8 FAS FASLG IL1A TNF
37
Show member pathways
12.32 CASP8 FAS FASLG IL1A IL1B NLRP3
38 12.31 CASP8 FAS FASLG TNF
39
Show member pathways
12.31 CXCL8 FAS FASLG IL1B IL6 TNF
40 12.29 CXCL8 IL1A IL1B IL6 TNF
41 12.25 CXCL8 IL1A IL6 TGFB1
42 12.2 CCL2 GSTM1 IL1A IL1B TNF
43
Show member pathways
12.18 CCL2 CXCL8 IL1A IL1B IL6 TGFB1
44
Show member pathways
12.17 CAT FASLG IL6 TGFB1
45 12.15 FAS IL6 TGFB1 TNF
46 12.14 IL1A IL1B TGFB1 TNF
47 12.09 CASP8 CCL2 FAS IL1B IL6 TNF
48 12.07 CXCL8 IL1A IL1B IL6 TGFB1
49 12.06 CCL2 CXCL8 IL1A IL1B IL6 TGFB1
50
Show member pathways
12.05 CASP8 CCL2 CXCL8 FAS FASLG HSPA1L

GO Terms for Pneumoconiosis

Cellular components related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CAT CCL2 CP CXCL8 FASLG IL1A
2 membrane raft GO:0045121 9.62 CASP8 FAS FASLG TNF
3 extracellular region GO:0005576 9.47 CAT CCL2 CP CXCL8 FAS FASLG
4 death-inducing signaling complex GO:0031264 9.26 CASP8 FAS
5 CD95 death-inducing signaling complex GO:0031265 9.16 CASP8 FAS

Biological processes related to Pneumoconiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.97 CASP8 CXCL8 FAS FASLG IL1B
2 immune response GO:0006955 9.97 CCL2 CXCL8 FAS FASLG IL1A IL1B
3 positive regulation of protein phosphorylation GO:0001934 9.96 FAS IL1B TGFB1 TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 CASP8 FASLG IL1A IL1B TNF
5 cellular response to lipopolysaccharide GO:0071222 9.92 CCL2 CXCL8 IL6 NLRP3 TNF
6 response to estradiol GO:0032355 9.9 CASP8 CAT TGFB1
7 response to organic substance GO:0010033 9.9 SOD1 TGFB1 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.9 IL6 NLRP3 TNF
9 apoptotic signaling pathway GO:0097190 9.9 CASP8 FAS FASLG TNF
10 cellular response to mechanical stimulus GO:0071260 9.89 CASP8 FAS IL1B TGFB1
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 IL6 TGFB1 TNF
12 positive regulation of JNK cascade GO:0046330 9.87 IL1A IL1B TNF
13 neutrophil chemotaxis GO:0030593 9.87 CCL2 CXCL8 IL1B
14 regulation of signaling receptor activity GO:0010469 9.86 CCL2 CXCL8 FASLG IL1A IL1B IL6
15 humoral immune response GO:0006959 9.85 CCL2 IL6 TNF
16 positive regulation of interleukin-6 production GO:0032755 9.84 IL1A IL1B IL6 TNF
17 negative regulation of fat cell differentiation GO:0045599 9.83 IL6 TGFB1 TNF
18 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.83 CASP8 FAS FASLG NLRP3 TNF
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.81 IL1A IL1B TNF
20 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.81 CASP8 FAS FASLG
21 positive regulation of cell division GO:0051781 9.81 CAT IL1A IL1B TGFB1
22 protein kinase B signaling GO:0043491 9.8 CCL2 IL1B TGFB1 TNF
23 cellular response to organic cyclic compound GO:0071407 9.8 CASP8 CCL2 IL1B TGFB1 TNF
24 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 CAT IL1B IL6 NLRP3 TGFB1 TNF
25 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.79 IL1B NLRP3 TNF
26 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.79 CASP8 FASLG TNF
27 positive regulation of vascular endothelial growth factor production GO:0010575 9.78 IL1A IL1B TGFB1
28 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.76 CASP8 FAS FASLG
29 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 CCL2 IL1B TGFB1 TNF
30 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.73 CASP8 FAS FASLG
31 response to reactive oxygen species GO:0000302 9.72 CAT SOD1
32 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1A IL1B
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
34 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.71 IL1A IL1B
35 PERK-mediated unfolded protein response GO:0036499 9.71 CCL2 CXCL8
36 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
37 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
38 death-inducing signaling complex assembly GO:0071550 9.69 CASP8 TNF
39 ectopic germ cell programmed cell death GO:0035234 9.69 IL1A IL1B
40 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
41 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.68 IL6 NLRP3
42 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
43 fever generation GO:0001660 9.66 IL1A IL1B
44 interleukin-1 beta production GO:0032611 9.65 IL1B NLRP3
45 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.65 IL1A TGFB1
46 necroptotic signaling pathway GO:0097527 9.65 FAS FASLG TNF
47 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 IL1B TNF
49 positive regulation of mononuclear cell migration GO:0071677 9.62 TGFB1 TNF
50 cytokine-mediated signaling pathway GO:0019221 9.56 CCL2 CXCL8 FASLG IL1A IL1B IL6

Molecular functions related to Pneumoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 9.33 CP IL1A SOD1
2 cytokine activity GO:0005125 9.23 CCL2 CXCL8 FASLG IL1A IL1B IL6
3 tumor necrosis factor receptor binding GO:0005164 9.13 CASP8 FASLG TNF
4 protein binding GO:0005515 10.16 CASP8 CAT CCL2 CXCL8 FAS FASLG

Sources for Pneumoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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