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MCID: PNM001
MIFTS: 55

Pneumocystosis

Categories: Rare diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pneumocystosis

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MalaCards integrated aliases for Pneumocystosis:

Name: Pneumocystosis 12 76 53 59 15
Pneumocystis Pneumonia 12 3
Pneumocystis Jirovecii Pneumonia 12
Pneumocystis Jiroveci Pneumonia 73
Pneumocystis Carinii Pneumonia 12
Pneumonia Pneumocystis Carinii 55
Pneumocystosis Pneumonia 12
Pulmonary Pneumocystosis 12
Pneumonia, Pneumocystis 44

Characteristics:

Orphanet epidemiological data:

59
pneumocystosis
Inheritance: Not applicable; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11339
ICD10 33 B59
ICD9CM 35 136.3
MeSH 44 D011020
NCIt 50 C3334
Orphanet 59 ORPHA723
ICD10 via Orphanet 34 B59+ J17.3*
UMLS via Orphanet 74 C1535939
UMLS 73 C1535939
Sources

Summaries for Pneumocystosis

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NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 723Disease definitionHuman pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localised to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.Visit the Orphanet disease page for more resources.

MalaCards based summary : Pneumocystosis, also known as pneumocystis pneumonia, is related to immunodeficiency with hyper-igm, type 1 and pneumonia, and has symptoms including nonproductive cough, shortness of breath and fever. An important gene associated with Pneumocystosis is DHPS (Deoxyhypusine Synthase), and among its related pathways/superpathways are Bacterial infections in CF airways and Hematopoietic cell lineage. The drugs Bupropion and Sertraline have been mentioned in the context of this disorder. Affiliated tissues include lungs, lung and kidney, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An opportunistic mycosis that is located in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has material basis in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has symptom nonproductive cough, has symptom shortness of breath, and has symptom fever.

CDC : 3 Pneumocystis jirovecii in the lung of an HIV/AIDS patient.

Wikipedia : 76 Pneumocystosis is an infection by Pneumocystis jirovecii, that primarily occurs as a pulmonary infection... more...

Sources

Related Diseases for Pneumocystosis

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Diseases related to Pneumocystosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 immunodeficiency with hyper-igm, type 1 33.0 CD40LG CD79A
2 pneumonia 30.1 CD40LG SFTPD TNF
3 cryptosporidiosis 30.0 CD40LG CD79A DHFR
4 toxoplasmosis 29.6 CD40LG CD79A DHFR TNF
5 aspergillosis 29.3 CD79A CLEC7A SFTPD
6 acquired immunodeficiency syndrome 28.9 ALB CD4 CD40LG CD79A TNF
7 otitis media 28.8 ALB CD40LG CD79A TNF
8 colorado tick fever 10.7 ALB CD40LG
9 fournier gangrene 10.7 ALB CD40LG
10 pleuroparenchymal fibroelastosis 10.6 MUC1 SFTPD
11 acute interstitial pneumonia 10.6 MUC1 SFTPD
12 selective igg deficiency disease 10.6 CD40LG CD79A
13 c1q nephropathy 10.6 CD40LG CD79A
14 meningovascular neurosyphilis 10.5 CD40LG CD79A
15 alpha chain disease 10.5 CD40LG CD79A
16 splenic disease 10.5 ALB CD40LG
17 brill-zinsser disease 10.5 CD40LG CD79A
18 exudative glomerulonephritis 10.5 CD40LG CD79A
19 aleutian mink disease 10.5 ALB CD40LG
20 salpingo-oophoritis 10.5 CD40LG CD79A
21 early yaws 10.5 CD40LG CD79A
22 chronic interstitial cystitis 10.5 CD40LG CD79A
23 axillary adenitis 10.5 CD40LG CD79A
24 cryofibrinogenemia 10.5 CD40LG CD79A
25 trichostrongyloidiasis 10.5 CD40LG CD79A
26 subacute bacterial endocarditis 10.5 CD40LG CD79A
27 heterophyiasis 10.5 CD40LG CD79A
28 immunoglobulin g deficiency 10.5 CD40LG CD79A
29 transient hypogammaglobulinemia of infancy 10.5 CD40LG CD79A
30 hyperglobulinemic purpura 10.5 CD40LG CD79A
31 gastroduodenitis 10.5 CD40LG CD79A
32 bacterial conjunctivitis 10.5 CD40LG CD79A
33 heavy chain disease 10.5 CD40LG CD79A
34 ophthalmia neonatorum 10.5 CD40LG CD79A
35 immunoglobulin a deficiency 1 10.5 CD40LG CD79A
36 ostertagiasis 10.5 ALB CD79A
37 parotid disease 10.5 CD40LG CD79A
38 cerebral arteritis 10.5 CD40LG CD79A
39 dermatitis, atopic, 3 10.5 ALB CD79A
40 myasthenic syndrome, congenital, 10 10.5 CD40LG MT-CYB
41 selective immunoglobulin deficiency disease 10.5 CD40LG CD79A
42 geniculate herpes zoster 10.5 CD40LG CD79A
43 erythema elevatum diutinum 10.5 CD40LG CD79A
44 sporotrichosis 10.5 CD40LG CD79A
45 fallopian tube disease 10.5 CD40LG CD79A
46 hyperimmunoglobulin syndrome 10.5 CD40LG CD79A
47 congenital syphilis 10.5 CD40LG CD79A
48 monoclonal paraproteinemia 10.5 CD40LG CD79A
49 salpingitis 10.5 CD40LG CD79A
50 ocular toxoplasmosis 10.5 CD40LG CD79A

Comorbidity relations with Pneumocystosis via Phenotypic Disease Network (PDN):


Deficiency Anemia Heart Disease
Neutropenia Oral Candidiasis
Postinflammatory Pulmonary Fibrosis Respiratory Failure

Graphical network of the top 20 diseases related to Pneumocystosis:



Diseases related to Pneumocystosis
Sources

Symptoms & Phenotypes for Pneumocystosis

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Symptoms:

12
  • • nonproductive cough
  • • shortness of breath
  • • fever

MGI Mouse Phenotypes related to Pneumocystosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 CLEC7A DHFR DHPS SFTPD TNF CD4
2 homeostasis/metabolism MP:0005376 9.65 CLEC7A DHFR DHPS FLNC SFTPD TNF
3 immune system MP:0005387 9.23 CD79A CLEC7A DHFR DHPS SFTPD TNF
Sources

Drugs & Therapeutics for Pneumocystosis

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Drugs for Pneumocystosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 357)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupropion Approved Phase 4,Not Applicable 34841-39-9, 34911-55-2 444
2
Sertraline Approved Phase 4,Not Applicable 79617-96-2 68617
3
Sulfamethoxazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 723-46-6 5329
4
Trimethoprim Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 738-70-5 5578
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
8
Pentamidine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 100-33-4 4735
9
Budesonide Approved Phase 4,Not Applicable 51333-22-3 63006 5281004
10
Phentermine Approved, Illicit Phase 4 122-09-8 4771
11
Topiramate Approved Phase 4 97240-79-4 5284627
12
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
13
Dalteparin Approved Phase 4,Phase 1 9005-49-6
14
Heparin Approved, Investigational Phase 4,Phase 1 9005-49-6 772 46507594
15
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
16
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
17
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702
18
Metronidazole Approved Phase 4,Not Applicable 443-48-1 4173
19
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
20
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 128794-94-5 5281078
21
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
22
Emtricitabine Approved, Investigational Phase 4,Phase 1,Phase 2 143491-57-0 60877
23
Nevirapine Approved Phase 4 129618-40-2 4463
24
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 1 155213-67-5 392622
25
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
26
Methylphenidate Approved, Investigational Phase 4,Phase 1 113-45-1 4158
27
Dapsone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 80-08-0 2955
28
Atovaquone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 95233-18-4 74989
29
Clindamycin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 18323-44-9 29029
30
Prednisone Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 53-03-2 5865
31
Primaquine Approved Phase 4,Phase 3,Not Applicable 90-34-6 4908
32
Morphine Approved, Investigational Phase 4,Phase 1,Not Applicable 57-27-2 5288826
33
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
34
Sumatriptan Approved, Investigational Phase 4 103628-46-2 5358
35
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
37
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 143 6006
38
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
39 Strawberry Approved, Nutraceutical Phase 4
40
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
41
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
42
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
43 Antidepressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Neurotransmitter Agents Phase 4,Phase 1,Phase 2,Not Applicable
45 Neurotransmitter Uptake Inhibitors Phase 4
46 Psychotropic Drugs Phase 4,Phase 1,Not Applicable
47 Serotonin Agents Phase 4
48 Serotonin Uptake Inhibitors Phase 4
49 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 494)
# Name Status NCT ID Phase Drugs
1 Depression Care Management for Depressed Elders in China Primary Care Unknown status NCT01287494 Phase 4 Sertraline
2 Gradual Initiation of Sulfamethoxazole/Trimethoprim as Primary Pneumocystis Carinii Pneumonia Prophylaxis Completed NCT00000816 Phase 4 Sulfamethoxazole-Trimethoprim
3 Evaluation of LEVITRA to Advance the Treatment of Erectile Dysfunction Completed NCT00664833 Phase 4
4 Effect of Weight and/or Obesity on Sulfamethoxazole and Trimethoprim Concentrations Completed NCT01167452 Phase 4 Sulfamethoxazole/trimethoprim
5 A Toolbox Approach to Obesity Treatment in Primary Care Completed NCT01922934 Phase 4 Obesity pharmacotherapy
6 Immediate Versus Deferred Antiretroviral Therapy in HIV-infected Patients Presenting With Acute AIDS-defining Events Completed NCT01417949 Phase 4
7 EMD and/or Bone Substitute for the Treatment of Class II Furcations Completed NCT02474498 Phase 4 EMD
8 Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy. Completed NCT02487186 Phase 4 Doxicicline
9 Primary Care Intervention Strategy for Anxiety Disorders Completed NCT00347269 Phase 4 Psychotropic medication optimization
10 Deferment of Imaging for Pulmonary Embolism Completed NCT00381511 Phase 4 low molecular weight heparin
11 Pharmacokinetics of Micafungin During Continuous Venovenous Hemofiltration Completed NCT02651038 Phase 4 Micafungin
12 Biomarker Study of Acamprosate in Schizophrenia Completed NCT00688324 Phase 4 Acamprosate
13 The Use of Erythritol Powder and Metronidazole Gel for the Non-surgical Treatment of Periodontitis Completed NCT02023840 Phase 4 metronidazole gel;placebo
14 Acute Otitis Media (AOM) Therapy Trial in Young Children Completed NCT00377260 Phase 4 amoxicillin-clavulanate;Placebo
15 VITamine D Supplementation in RenAL Transplant Recipients - VITALE Completed NCT01431430 Phase 4 Cholecalciferol 100 000 UI;Cholecalciferol 12 000 UI
16 A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation Completed NCT00048165 Phase 4 Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
17 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
18 Methylphenidate Treatment of Attention Deficits in Epilepsy Completed NCT02178995 Phase 4 Methylphenidate
19 Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria Recruiting NCT03087890 Phase 4 Cotrimoxazole;Placebo
20 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
21 A Prospective Evaluation of Natriuretic Peptide Based Referral of CHF Patients in Primary Care Recruiting NCT02807857 Phase 4
22 Correcting Anemia and Native Vitamin D Supplementation in Kidney Transplant Recipients Enrolling by invitation NCT01817699 Phase 4
23 Improving Health Outcomes of Migraine Patients Who Present to the Emergency Department Not yet recruiting NCT02945839 Phase 4 Preventative Medication (PM)
24 Dissemination of Prostate Cancer Screening to PCP's in African American Communities Terminated NCT00629330 Phase 4
25 Conversion to Embeda With Rescue Trial Terminated NCT01179191 Phase 4 morphine sulfate and naltrexone hydrochloride (EMBEDA)
26 Corticosteroids Therapy and Pneumocystis Jirovecii Pneumonia (PCP) Withdrawn NCT00636935 Phase 4 Antibiotics only;Antibiotics + Corticosteroids;Corticosteroids + antibiotics
27 Pulmicort Respules on Relapse Rates After Treatment in the ED Withdrawn NCT00584636 Phase 4 pulmicort respules
28 Study of Trimethoprim/Sulfamethoxazole as PCP Prophylaxis in CTD Patients Unknown status NCT01747278 Phase 2, Phase 3 Trimethoprim/Sulfamethoxazole
29 Dementia Early Recognition and Response in Primary Care Unknown status NCT00866099 Phase 2, Phase 3
30 A Study of Pentamidine Plus Dapsone in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Patients Who Cannot Take Trimethoprim or Sulfonamides Completed NCT00001028 Phase 3 Pentamidine isethionate;Dapsone
31 A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides Completed NCT00000802 Phase 3 Atovaquone;Dapsone
32 A Randomized, Comparative, Prospective Study of Daily Trimethoprim / Sulfamethoxazole (TMS) and Thrice-Weekly TMS for Prophylaxis Against PCP in HIV-Infected Patients Completed NCT00000748 Phase 3 Sulfamethoxazole-Trimethoprim
33 A Study of Trimetrexate With Leucovorin Rescue for AIDS Patients Who Are Refractory to Standard Therapies for Pneumocystis Carinii Pneumonia Completed NCT00000724 Phase 3 Trimetrexate glucuronate;Leucovorin calcium
34 A Treatment Protocol for the Use of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia and Serious Intolerance to Approved Therapies Completed NCT00001016 Phase 3 Trimetrexate glucuronate;Leucovorin calcium
35 Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Completed NCT00001014 Phase 3 Trimetrexate glucuronate;Sulfamethoxazole-Trimethoprim;Leucovorin calcium
36 A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia in AIDS Completed NCT00000715 Phase 3 Pentamidine isethionate;Sulfamethoxazole-Trimethoprim
37 A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT) Completed NCT00000727 Phase 3 Pentamidine isethionate;Pyrimethamine;Sulfamethoxazole/Trimethoprim;Sulfadoxine/Pyrimethamine;Zidovudine
38 An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies Completed NCT00000714 Phase 3 Trimetrexate glucuronate;Leucovorin calcium
39 A Comparison of Atovaquone and Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia in HIV-Infected Patients Who Cannot Take TMP/SMX Completed NCT00002340 Phase 3 Atovaquone;Pentamidine isethionate
40 Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Completed NCT00001013 Phase 3 Trimetrexate glucuronate;Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Leucovorin calcium
41 A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS Completed NCT00000640 Phase 3 Primaquine;Sulfamethoxazole-Trimethoprim;Dapsone;Clindamycin
42 Virtual Continuity and Its Impact on Complex Hospitalized Patients' Care Completed NCT01397253 Phase 3
43 A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients Completed NCT00000991 Phase 3 Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Dapsone;Zidovudine
44 A Randomized, Unblinded Trial of Zidovudine Versus ddC in the Treatment of Patients Status Post PCP Who Received Long-Term Zidovudine Therapy in Protocol ACTG 002 Completed NCT00000682 Phase 3 Zidovudine;Zalcitabine
45 A Multi-Center Clinical Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS Post First Episode PCP Completed NCT00000700 Phase 3 Zidovudine
46 The Congestive Heart Failure Adherence Redesign Trial Completed NCT01698242 Phase 3
47 Using Social Incentives and Gamification for Weight Loss Promotion Completed NCT02564445 Phase 3
48 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
49 Cognitive Remediation With D-Cycloserine Completed NCT01399866 Phase 3 D-cycloserine;Placebo
50 Online Treatments for Mood and Anxiety Disorders in Primary Care Completed NCT01482806 Phase 2, Phase 3

Search NIH Clinical Center for Pneumocystosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: pneumonia, pneumocystis

Sources

Genetic Tests for Pneumocystosis

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Sources

Anatomical Context for Pneumocystosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Pneumocystosis:

19
Lungs

MalaCards organs/tissues related to Pneumocystosis:

41
Lung, Kidney, Testes, Heart, Skin, Bone, Liver
Sources

Publications for Pneumocystosis

About this section

Articles related to Pneumocystosis:

(show top 50) (show all 196)
# Title Authors Year
1
Pneumocystosis and quantitative PCR. ( 29789160 )
2018
2
Cytomegalovirus Infection and Graft Rejection as Risk Factors for Pneumocystis Pneumonia in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis. ( 29956379 )
2018
3
Rapid glucocorticoid tapering therapy to reduce mortality from pneumocystis pneumonia in patients with rheumatic disease. ( 29972334 )
2018
4
Pneumocystosis in dogs: meta-analysis of 43 published cases including clinical signs, diagnostic procedures, and treatment. ( 29145787 )
2018
5
Pneumocystis Pneumonia Concomitant with Ectopic ACTH Syndrome Caused by a Large Cell Neuroendocrine Carcinoma of the Thymus. ( 28250304 )
2017
6
Successful Treatment of Pulmonary and Cerebral Toxoplasmosis Associated with Pneumocystis Pneumonia in an HIV Patient. ( 29258242 )
2017
7
The changing trends and profile of pneumocystosis mortality in the United States, 1999-2014. ( 28568970 )
2017
8
Pneumocystis pneumonia in patients with inflammatory or autoimmune diseases: Usefulness of lymphocyte subtyping. ( 28223177 )
2017
9
Characteristics and Mortality of Pneumocystis Pneumonia in Patients With Cushing's Syndrome: A Plea for Timely Initiation of Chemoprophylaxis. ( 28480275 )
2017
10
Reliable differentiation of Pneumocystis pneumonia from Pneumocystis colonization by quantification of Major Surface Glycoprotein gene using real-time polymerase chain reaction. ( 28945326 )
2017
11
Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese Patients with Rheumatoid Arthritis. ( 29181029 )
2017
12
Pneumocystosis revealing immunodeficiency secondary to<i>TERC</i>mutation. ( 29167304 )
2017
13
Grouped Cases of Pulmonary Pneumocystosis After Solid Organ Transplantation: Advantages of Coordination by an Infectious Diseases Unit for Overall Management and Epidemiological Monitoring. ( 27890037 )
2017
14
The lung microbiome in patients with pneumocystosis. ( 29202739 )
2017
15
Efficiency of interleukin-6 and interferon-I^ in the differentiation of invasive pulmonary aspergillosis and pneumocystis pneumonia in pediatric oncology patients. ( 27208634 )
2016
16
Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia. ( 26942578 )
2016
17
Serological diagnosis of pneumocystosis: production of a synthetic recombinant antigen for immunodetection of Pneumocystis jirovecii. ( 27824115 )
2016
18
Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia. ( 26901377 )
2016
19
Weighing the risks and benefits of Pneumocystis pneumonia prophylaxis in iatrogenically immunosuppressed dermatology patients. ( 27653234 )
2016
20
Pneumocystis pneumonia associated with peripheral lymphocytosis in angioimmunoblastic T-cell lymphoma, resembling immune reconstitution syndrome. ( 27544629 )
2016
21
Risk factors for pneumocystis pneumonia in giant cell arteritis: a single-centre cohort study. ( 26016762 )
2015
22
Complications and Outcomes of Trimethoprim-Sulphamethoxazole as Chemoprophylaxis for Pneumocystis Pneumonia in Renal Transplant Recipients. ( 24387294 )
2014
23
Pneumocystis and Pneumocystosis: first meeting of experts from Latin-American and Portuguese-speaking countries - a mini-review. ( 24617414 )
2014
24
Fatal late-onset pneumocystis pneumonia after rituximab: administration for posttransplantation recurrence of focal segmental glomerulosclerosis-case report. ( 25380948 )
2014
25
Pneumocystis Pneumonia - A Novel Complication in a Non-HIV Dengue Patient. ( 25386504 )
2014
26
Myeloid-Derived Suppressor Cells Impair Alveolar Macrophages Through PD-1 Receptor Ligation During Pneumocystis Pneumonia. ( 25404033 )
2014
27
Pneumocystis pneumonia in South African children diagnosed by molecular methods. ( 24410938 )
2014
28
Concomitant occurrence of pulmonary invasive aspergillosis and Pneumocystis pneumonia during FOLFIRINOX chemotherapy for pancreatic carcinoma. ( 23254917 )
2013
29
Early development of immune reconstitution inflammatory syndrome related to Pneumocystis pneumonia after antiretroviral therapy. ( 24122663 )
2013
30
Point prevalence of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma according to the number of cycles of R-CHOP chemotherapy. ( 23053189 )
2013
31
Pneumocystis Pneumonia in Patients Treated With Long-Term Steroid Therapy for Symptom Palliation: A Neglected Infection in Palliative Care. ( 24081789 )
2013
32
Intravenous pentamidine is safe and effective as primary pneumocystis pneumonia prophylaxis in children and adolescents undergoing hematopoietic stem cell transplantation. ( 23538522 )
2013
33
Pneumocystis pneumonia induced by treatment with low-dose tacrolimus and methylprednisolone in a patient with rheumatoid arthritis: a case report. ( 24289285 )
2013
34
Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: protocol for a systematic review. ( 24330755 )
2013
35
Ambient air pollution associated with suppressed serologic responses to Pneumocystis jirovecii in a prospective cohort of HIV-infected patients with Pneumocystis pneumonia. ( 24236202 )
2013
36
Characteristics of Pneumocystis pneumonia in Nancy from January 2007 to April 2011 and focus on an outbreak in nephrology. ( 24387807 )
2013
37
Humoral Immune Responses to Pneumocystis jirovecii Antigens in HIV-Infected and Uninfected Young Children with Pneumocystis Pneumonia. ( 24386119 )
2013
38
Single-Day Trimethoprim/Sulfamethoxazole Prophylaxis for Pneumocystis Pneumonia in Children with Cancer. ( 24252793 )
2013
39
Outcomes of non-HIV-infected patients with Pneumocystis pneumonia and concomitant pulmonary cytomegalovirus infection. ( 22264016 )
2012
40
A successful diagnostic case of Pneumocystis pneumonia by the loop-mediated isothermal amplification method in a patient with dermatomyositis. ( 22526388 )
2012
41
Pneumocystosis in a patient with Crohn's disease treated with combination therapy with adalimumab. ( 22398055 )
2012
42
Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia. ( 22046140 )
2011
43
Hypercalcemia and pneumocystis Pneumonia after kidney transplantation: report of an exceptional case and literature review. ( 21414118 )
2011
44
Dynamics of Pneumocystis carinii air shedding during experimental pneumocystosis. ( 21372312 )
2011
45
Pneumocystosis: a network survey in the Paris area 2003-2008. ( 21229281 )
2011
46
Pulmonary nocardiosis caused by Nocardia exalbida complicating Pneumocystis pneumonia in an HIV-infected patient. ( 21249414 )
2011
47
Pneumocystis pneumonia during medicamentous treatment of Cushing's syndrome--a description of two cases. ( 22250484 )
2011
48
Defective nitric oxide production by alveolar macrophages during Pneumocystis pneumonia. ( 20558778 )
2011
49
Epidemiological characteristics of pulmonary pneumocystosis and concurrent infections in pigs in Jeju Island, Korea. ( 21368558 )
2011
50
High prevalence of dihydropteroate synthase mutations in Pneumocystis jirovecii isolated from patients with Pneumocystis pneumonia in South Africa. ( 20351205 )
2010
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Variations for Pneumocystosis

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Expression for Pneumocystosis

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Search GEO for disease gene expression data for Pneumocystosis.
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Pathways for Pneumocystosis

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Pathways related to Pneumocystosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Bacterial infections in CF airways 22
Show member pathways
 11.72 MUC1 SFTPD TNF
2
Hematopoietic cell lineage 37
11.42 CD4 GYPA TNF
3
Malaria 37
11.02 CD40LG GYPA TNF
4
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
10.99 CD4 CD79A GYPA TNF
5
Primary immunodeficiency 37
10.7 CD4 CD40LG CD79A
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GO Terms for Pneumocystosis

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Cellular components related to Pneumocystosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multivesicular body GO:0005771 8.96 CD79A SFTPD
2 external side of plasma membrane GO:0009897 8.92 CD4 CD40LG CD79A TNF

Biological processes related to Pneumocystosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.13 CD4 CD40LG DHPS
2 regulation of immunoglobulin secretion GO:0051023 8.62 CD40LG TNF

Molecular functions related to Pneumocystosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.1 ALB CD4 DHPS GYPA SFTPD TNF
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Sources for Pneumocystosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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