Pneumocystosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

PCP MCID: PNM001 MIFTS: 58	Pneumocystosis (PCP) Categories: Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases, Skin diseases
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Aliases & Classifications for Pneumocystosis

MalaCards integrated aliases for Pneumocystosis:

Name: Pneumocystosis ¹² ⁷⁷ ⁵⁴ ⁶⁰ ¹⁵ ¹⁷

Pneumocystis Carinii Pneumonia ¹² ¹⁵

Pneumocystis Pneumonia ¹² ³

Pcp ⁴⁹ ³

Pneumocystis Jirovecii Pneumonia ¹²

Pneumocystis Jiroveci Pneumonia ⁷⁴

Pneumonia Pneumocystis Carinii ⁵⁶

Pneumocystosis Pneumonia ¹²

Pulmonary Pneumocystosis ¹²

Pneumonia, Pneumocystis ⁴⁵

Characteristics:

Orphanet epidemiological data:

⁶⁰

pneumocystosis
Inheritance: Not applicable; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Respiratory diseases Skin diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Certain infectious and parasitic diseases

Protozoal diseases

Pneumocystosis

Orphanet: ⁶⁰

Rare infectious diseases

External Ids:

Disease Ontology ¹² DOID:11339

ICD9CM ³⁶ 136.3

MeSH ⁴⁵ D011020

NCIt ⁵¹ C3334

SNOMED-CT ⁶⁹ 57541005 88860002

ICD10 ³⁴ B59

ICD10 via Orphanet ³⁵ B59+ J17.3*

UMLS via Orphanet ⁷⁵ C1535939

Orphanet ⁶⁰ ORPHA723

EFO ¹⁷ EFO_0007448

UMLS ⁷⁴ C1535939

Sources

Summaries for Pneumocystosis

NIH Rare Diseases : ⁵⁴ The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 723Disease definitionHuman pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localised to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.Visit the Orphanet disease page for more resources.

MalaCards based summary : Pneumocystosis, also known as pneumocystis carinii pneumonia, is related to respiratory failure and acquired immunodeficiency syndrome. An important gene associated with Pneumocystosis is DHPS (Deoxyhypusine Synthase), and among its related pathways/superpathways are 4-1BB Pathway and Immune response NFAT in immune response. The drugs Bupropion and Sertraline have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : ¹² An opportunistic mycosis that is located in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has material basis in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has symptom nonproductive cough, has symptom shortness of breath, and has symptom fever.

CDC : ³ Pneumocystis pneumonia (PCP) is a serious infection caused by the fungus Pneumocystis jirovecii.

Wikipedia : ⁷⁷ Pneumocystosis is an infection by Pneumocystis jirovecii, that primarily occurs as a pulmonary infection... more...

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Related Diseases for Pneumocystosis

Diseases related to Pneumocystosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)

#	Related Disease	Score	Top Affiliating Genes
1	respiratory failure	31.1	ALB SFTPD TNF
2	acquired immunodeficiency syndrome	30.6	ALB CD4 TNF
3	toxoplasmosis	30.6	CD40LG DHFR TNF
4	connective tissue disease	30.4	CD40LG MUC1 SFTPD TNF
5	cryptosporidiosis	30.3	CD40LG DHFR
6	pneumonia	30.2	CD40LG DHPS SFTPD TNF
7	schistosomiasis	30.1	ALB CD40LG TNF
8	vasculitis	30.1	CD40LG TNF TNFRSF1B
9	interstitial lung disease	30.0	MUC1 SFTPD TNF
10	aspergillosis	30.0	CLEC7A SFTPD TNF
11	hepatitis e	29.9	ALB CD40LG TNF
12	pulmonary fibrosis, idiopathic	29.9	MUC1 SFTPD TNF
13	hematopoietic stem cell transplantation	29.7	CLEC7A TNF
14	phencyclidine abuse	11.9
15	immunodeficiency with hyper-igm, type 1	11.8
16	human immunodeficiency virus infectious disease	10.8
17	leukemia	10.7
18	pneumothorax	10.7
19	arthritis	10.6
20	rheumatoid arthritis	10.6
21	encephalitis	10.6
22	systemic lupus erythematosus	10.5
23	lupus erythematosus	10.5
24	bacterial pneumonia	10.5
25	lymphocytic leukemia	10.5
26	cytomegalovirus infection	10.5
27	breast cancer	10.5
28	pneumothorax, primary spontaneous	10.5
29	lymphoma	10.5
30	colitis	10.5
31	ulcerative colitis	10.4
32	agammaglobulinemia	10.4
33	pulmonary tuberculosis	10.4
34	human immunodeficiency virus type 1	10.4
35	leukemia, acute lymphoblastic	10.4
36	sarcoma	10.4
37	conn's syndrome	10.4
38	myeloma, multiple	10.3
39	asthma	10.3
40	pancytopenia	10.3
41	tropical calcific pancreatitis	10.3
42	hypersplenism	10.3	ALB CD4
43	neuroblastoma	10.3
44	west syndrome	10.3
45	lung disease	10.3
46	hemophilia	10.3
47	cytomegalic inclusion disease	10.3
48	fournier gangrene	10.3	ALB CD40LG
49	pleuroparenchymal fibroelastosis	10.3	MUC1 SFTPD
50	acute interstitial pneumonia	10.3	MUC1 SFTPD

Comorbidity relations with Pneumocystosis via Phenotypic Disease Network (PDN):

Deficiency Anemia	Heart Disease
Neutropenia	Oral Candidiasis
Postinflammatory Pulmonary Fibrosis	Respiratory Failure

Graphical network of the top 20 diseases related to Pneumocystosis:

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Symptoms & Phenotypes for Pneumocystosis

MGI Mouse Phenotypes related to Pneumocystosis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.86	CD4 CD40LG CLEC7A DHFR DHPS SFTPD
2	homeostasis/metabolism	MP:0005376	9.85	ALB CD4 CD40LG CLEC7A DHFR DHPS
3	immune system	MP:0005387	9.61	CD4 CD40LG CLEC7A DHFR DHPS SFTPD
4	mortality/aging	MP:0010768	9.28	ALB CD4 CD40LG CLEC7A DHFR DHPS

Sources

Drugs & Therapeutics for Pneumocystosis

Drugs for Pneumocystosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 392)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bupropion

Approved

Phase 4,Not Applicable

34841-39-9, 34911-55-2

444

Sertraline

Approved

Phase 4,Not Applicable

79617-96-2

68617

Sulfamethoxazole

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

723-46-6

5329

Trimethoprim

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

738-70-5

5578

leucovorin

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

58-05-9

6006 143

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

22916-47-8

4189

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

83-43-2

6741

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2921-57-5

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

50-24-8

5755

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

302-25-0

Pentamidine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable

100-33-4

4735

Budesonide

Approved

Phase 4,Not Applicable

51333-22-3

63006 5281004

Phentermine

Approved, Illicit

Phase 4

122-09-8

4771

Topiramate

Approved

Phase 4

97240-79-4

5284627

Doxycycline

Approved, Investigational, Vet_approved

Phase 4

564-25-0

54671203

Heparin

Approved, Investigational

Phase 4,Phase 1

9005-49-6

772 46507594

Dalteparin

Approved

Phase 4,Phase 1

9005-49-6

Micafungin

Approved, Investigational

Phase 4

235114-32-6

477468 3081921

Ethanol

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

64-17-5

702

Acamprosate

Approved, Investigational

Phase 4

77337-76-9

71158

Metronidazole

Approved

Phase 4,Not Applicable

443-48-1

4173

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Clavulanate

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Strawberry

Approved

Phase 4

Mycophenolic acid

Approved

Phase 4,Phase 3,Phase 1,Phase 2

24280-93-1

446541

Nevirapine

Approved

Phase 4

129618-40-2

4463

Emtricitabine

Approved, Investigational

Phase 4,Phase 1,Phase 2

143491-57-0

60877

Ritonavir

Approved, Investigational

Phase 4,Phase 3,Phase 1

155213-67-5

392622

Dopamine

Approved

Phase 4

62-31-7, 51-61-6

681

Methylphenidate

Approved, Investigational

Phase 4,Phase 1

113-45-1

4158

Dapsone

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

80-08-0

2955

Primaquine

Approved

Phase 4,Phase 3,Not Applicable

90-34-6

4908

Prednisone

Approved, Vet_approved

Phase 4,Phase 1,Phase 2,Not Applicable

53-03-2

5865

Clindamycin

Approved, Vet_approved

Phase 4,Phase 3,Not Applicable

18323-44-9

29029

Atovaquone

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

95233-18-4

74989

Morphine

Approved, Investigational

Phase 4,Phase 1,Not Applicable

57-27-2

5288826

Naproxen

Approved, Vet_approved

Phase 4

22204-53-1

156391 1302

Metformin

Approved

Phase 4,Phase 3

657-24-9

14219 4091

Naltrexone

Approved, Investigational, Vet_approved

Phase 4

16590-41-3

5360515

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

59-30-3

6037

Glutamic Acid

Approved, Nutraceutical

Phase 4

56-86-0

33032

Vitamin D

Approved, Nutraceutical, Vet_approved

Phase 4

1406-16-2

Vitamin D3

Approved, Nutraceutical

Phase 4

67-97-0

5280795 6221

Calcium

Approved, Nutraceutical

Phase 4,Phase 3,Phase 1,Not Applicable

7440-70-2

271

Ergocalciferol

Approved, Nutraceutical

Phase 4

50-14-6

5280793

Prednisolone hemisuccinate

Experimental

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2920-86-7

Tenofovir

Experimental, Investigational

Phase 4

147127-20-6

464205

Antidepressive Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Neurotransmitter Uptake Inhibitors

Phase 4

Psychotropic Drugs

Phase 4,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 543)

#	Name	Status	NCT ID	Phase	Drugs
1	Depression Care Management for Depressed Elders in China Primary Care	Unknown status	NCT01287494	Phase 4	Sertraline
2	Gradual Initiation of Sulfamethoxazole/Trimethoprim as Primary Pneumocystis Carinii Pneumonia Prophylaxis	Completed	NCT00000816	Phase 4	Sulfamethoxazole-Trimethoprim
3	Evaluation of LEVITRA to Advance the Treatment of Erectile Dysfunction	Completed	NCT00664833	Phase 4
4	Effect of Weight and/or Obesity on Sulfamethoxazole and Trimethoprim Concentrations	Completed	NCT01167452	Phase 4	Sulfamethoxazole/trimethoprim
5	A Toolbox Approach to Obesity Treatment in Primary Care	Completed	NCT01922934	Phase 4	Obesity pharmacotherapy
6	Immediate Versus Deferred Antiretroviral Therapy in HIV-infected Patients Presenting With Acute AIDS-defining Events	Completed	NCT01417949	Phase 4
7	EMD and/or Bone Substitute for the Treatment of Class II Furcations	Completed	NCT02474498	Phase 4	EMD
8	Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy.	Completed	NCT02487186	Phase 4	Doxicicline
9	Primary Care Intervention Strategy for Anxiety Disorders	Completed	NCT00347269	Phase 4	Psychotropic medication optimization
10	Deferment of Imaging for Pulmonary Embolism	Completed	NCT00381511	Phase 4	low molecular weight heparin
11	Pharmacokinetics of Micafungin During Continuous Venovenous Hemofiltration	Completed	NCT02651038	Phase 4	Micafungin
12	Biomarker Study of Acamprosate in Schizophrenia	Completed	NCT00688324	Phase 4	Acamprosate
13	The Use of Erythritol Powder and Metronidazole Gel for the Non-surgical Treatment of Periodontitis	Completed	NCT02023840	Phase 4	metronidazole gel;placebo
14	Acute Otitis Media (AOM) Therapy Trial in Young Children	Completed	NCT00377260	Phase 4	amoxicillin-clavulanate;Placebo
15	VITamine D Supplementation in RenAL Transplant Recipients - VITALE	Completed	NCT01431430	Phase 4	Cholecalciferol 100 000 UI;Cholecalciferol 12 000 UI
16	A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation	Completed	NCT00048165	Phase 4	Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
17	Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT)	Completed	NCT00552240	Phase 4	tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
18	Methylphenidate Treatment of Attention Deficits in Epilepsy	Completed	NCT02178995	Phase 4	Methylphenidate
19	Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria	Recruiting	NCT03087890	Phase 4	Cotrimoxazole;Placebo
20	Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome	Recruiting	NCT02550080	Phase 4	Dapsone
21	A Prospective Evaluation of Natriuretic Peptide Based Referral of CHF Patients in Primary Care	Recruiting	NCT02807857	Phase 4
22	A Prospective Cohort Study to Improve HCV Care in Dialysis Patients	Not yet recruiting	NCT03791814	Phase 4	Zepatier
23	Improving Health Outcomes of Migraine Patients Who Present to the Emergency Department	Not yet recruiting	NCT02945839	Phase 4	Preventative Medication (PM)
24	Approaches To Therapy Escalation In T2D	Not yet recruiting	NCT03813316	Phase 4	DPP-4 inhibitor;SGLT2 inhibitor;SGLT2 inhibitor and DPP-4 inhibitor
25	Dissemination of Prostate Cancer Screening to PCP's in African American Communities	Terminated	NCT00629330	Phase 4
26	Conversion to Embeda With Rescue Trial	Terminated	NCT01179191	Phase 4	morphine sulfate and naltrexone hydrochloride (EMBEDA)
27	Correcting Anemia and Native Vitamin D Supplementation in Kidney Transplant Recipients	Terminated	NCT01817699	Phase 4
28	Corticosteroids Therapy and Pneumocystis Jirovecii Pneumonia (PCP)	Withdrawn	NCT00636935	Phase 4	Antibiotics only;Antibiotics + Corticosteroids;Corticosteroids + antibiotics
29	Pulmicort Respules on Relapse Rates After Treatment in the ED	Withdrawn	NCT00584636	Phase 4	pulmicort respules
30	Study of Trimethoprim/Sulfamethoxazole as PCP Prophylaxis in CTD Patients	Unknown status	NCT01747278	Phase 2, Phase 3	Trimethoprim/Sulfamethoxazole
31	Efficacy of Phytolacca Decandra and Melissa Officinalis in Children With Nocturnal Bruxism	Unknown status	NCT02870543	Phase 3	Phytolacca decandra;Melissa officinalis;Phyt.decandra + Melissa offic.
32	A Study of Pentamidine Plus Dapsone in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Patients Who Cannot Take Trimethoprim or Sulfonamides	Completed	NCT00001028	Phase 3	Pentamidine isethionate;Dapsone
33	A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides	Completed	NCT00000802	Phase 3	Atovaquone;Dapsone
34	A Randomized, Comparative, Prospective Study of Daily Trimethoprim / Sulfamethoxazole (TMS) and Thrice-Weekly TMS for Prophylaxis Against PCP in HIV-Infected Patients	Completed	NCT00000748	Phase 3	Sulfamethoxazole-Trimethoprim
35	A Study of Trimetrexate With Leucovorin Rescue for AIDS Patients Who Are Refractory to Standard Therapies for Pneumocystis Carinii Pneumonia	Completed	NCT00000724	Phase 3	Trimetrexate glucuronate;Leucovorin calcium
36	A Treatment Protocol for the Use of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia and Serious Intolerance to Approved Therapies	Completed	NCT00001016	Phase 3	Trimetrexate glucuronate;Leucovorin calcium
37	Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS	Completed	NCT00001014	Phase 3	Trimetrexate glucuronate;Sulfamethoxazole-Trimethoprim;Leucovorin calcium
38	A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia in AIDS	Completed	NCT00000715	Phase 3	Pentamidine isethionate;Sulfamethoxazole-Trimethoprim
39	A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT)	Completed	NCT00000727	Phase 3	Pentamidine isethionate;Pyrimethamine;Sulfamethoxazole/Trimethoprim;Sulfadoxine/Pyrimethamine;Zidovudine
40	An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies	Completed	NCT00000714	Phase 3	Trimetrexate glucuronate;Leucovorin calcium
41	A Comparison of Atovaquone and Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia in HIV-Infected Patients Who Cannot Take TMP/SMX	Completed	NCT00002340	Phase 3	Atovaquone;Pentamidine isethionate
42	Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS	Completed	NCT00001013	Phase 3	Trimetrexate glucuronate;Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Leucovorin calcium
43	A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS	Completed	NCT00000640	Phase 3	Primaquine;Sulfamethoxazole-Trimethoprim;Dapsone;Clindamycin
44	Virtual Continuity and Its Impact on Complex Hospitalized Patients' Care	Completed	NCT01397253	Phase 3
45	A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients	Completed	NCT00000991	Phase 3	Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Dapsone;Zidovudine
46	A Randomized, Unblinded Trial of Zidovudine Versus ddC in the Treatment of Patients Status Post PCP Who Received Long-Term Zidovudine Therapy in Protocol ACTG 002	Completed	NCT00000682	Phase 3	Zidovudine;Zalcitabine
47	A Multi-Center Clinical Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS Post First Episode PCP	Completed	NCT00000700	Phase 3	Zidovudine
48	The Congestive Heart Failure Adherence Redesign Trial	Completed	NCT01698242	Phase 3
49	Using Social Incentives and Gamification for Weight Loss Promotion	Completed	NCT02564445	Phase 3
50	Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081)	Completed	NCT00000676	Phase 3	Clotrimazole;Fluconazole

Search NIH Clinical Center for Pneumocystosis

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

atovaquone

clindamycin phosphate pwdr

pentamidine

pentamidine isethionate

sulfadoxine

trimethoprim sulfate

trimetrexate

Cochrane evidence based reviews: pneumonia, pneumocystis

Sources

Genetic Tests for Pneumocystosis

Sources

Anatomical Context for Pneumocystosis

MalaCards organs/tissues related to Pneumocystosis:

⁴²

Lung, Kidney, Testes, Bone, Skin, Heart, Liver

Sources

Publications for Pneumocystosis

Articles related to Pneumocystosis:

(show top 50) (show all 1834)

#	Title	Authors	Year
1	Incidence of pneumocystosis among patients exposed to immunosuppression. ( 30639289 )	Rekhtman S...Garg A	2019
2	Genetic polymorphisms associated with treatment failure and mortality in pediatric Pneumocystosis. ( 30718779 )	Singh Y...Agarwal SK	2019
3	Pneumocystosis and quantitative PCR. ( 29789160 )	Issa N....Camou F.	2018
4	Pneumocystosis in dogs: meta-analysis of 43 published cases including clinical signs, diagnostic procedures, and treatment. ( 29145787 )	Weissenbacher-Lang C....KA1nzel F.	2018
5	CT findings in Pneumocystis carinii pneumonia in five dogs. ( 29577303 )	Schiborra F...Maddox TW	2018
6	The changing trends and profile of pneumocystosis mortality in the United States, 1999-2014. ( 28568970 )	Wickramasekaran R.N....Kuo T.	2017
7	Multiple myeloma presenting with bilateral ankle pain (microangiopathy) and complicated by streptococcal meningitis and Pneumocystis carinii pneumonia. ( 28174184 )	Dunphy L....Keating E.	2017
8	Pneumocystosis revealing immunodeficiency secondary to<i>TERC</i>mutation. ( 29167304 )	Borie R....Crestani B.	2017
9	Grouped Cases of Pulmonary Pneumocystosis After Solid Organ Transplantation: Advantages of Coordination by an Infectious Diseases Unit for Overall Management and Epidemiological Monitoring. ( 27890037 )	Wintenberger C....Epaulard O.	2017
10	The lung microbiome in patients with pneumocystosis. ( 29202739 )	Kehrmann J....Steinmann J.	2017
11	Risk factors for mortality from pneumocystis carinii pneumonia (PCP) in non-HIV patients: a meta-analysis. ( 28938676 )	Liu Y...Qu H	2017
12	Serological diagnosis of pneumocystosis: production of a synthetic recombinant antigen for immunodetection of Pneumocystis jirovecii. ( 27824115 )	TomA!s A.L....Matos O.	2016
13	Increased dosage of infliximab is a potential cause of Pneumocystis carinii pneumonia. ( 26839596 )	Iwama T...Ikuta K	2016
14	Common variable immune deficiency in a Pomeranian with Pneumocystis carinii pneumonia. ( 25715954 )	Kanemoto H....Nakayama H.	2015
15	Pneumocystis and Pneumocystosis: first meeting of experts from Latin-American and Portuguese-speaking countries - a mini-review. ( 24617414 )	Esteves F....Matos O.	2014
16	Adjunctive glucocorticoid therapy for non-HIV-related pneumocystis carinii pneumonia (NH-PCP). ( 24666835 )	McKinnell JA...Gregson A	2014
17	Histopathology of Pneumocystis carinii pneumonia in immunocompetent laboratory rats. ( 25009598 )	Kim HS...Kim YW	2014
18	Efficacy of caspofungin, a 1,3-β-D-glucan synthase inhibitor, on Pneumocystis carinii pneumonia in rats. ( 25288652 )	Sun P...Tong Z	2014
19	Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review. ( 24275372 )	Coelho L....Luz P.M.	2013
20	Clinical outcomes of Pneumocystis carinii pneumonia in adult liver transplant recipients. ( 24157035 )	Choi Y.I....Lee S.G.	2013
21	Pneumocystosis in a patient with Crohn's disease treated with combination therapy with adalimumab. ( 22398055 )	Desales A.L....Dehesa-Violante M.	2012
22	Pneumocystis carinii pneumonia in gastric cancer patients without acquired immune deficiency syndrome: 3 cases report and literature review. ( 22792534 )	Yoon SY...Yoo MW	2012
23	Chitinases in Pneumocystis carinii pneumonia. ( 22535444 )	Villegas LR...Limper AH	2012
24	Dynamics of Pneumocystis carinii air shedding during experimental pneumocystosis. ( 21372312 )	Choukri F....Derouin F.	2011
25	Pneumocystosis: a network survey in the Paris area 2003-2008. ( 21229281 )	Magne D....Roux P.	2011
26	Epidemiological characteristics of pulmonary pneumocystosis and concurrent infections in pigs in Jeju Island, Korea. ( 21368558 )	Kim K.S....Kim J.H.	2011
27	Pneumocystis carinii pneumonia prophylaxis: current therapies and recommendations. ( 21636828 )	Crozier F	2011
28	Development of Pneumocystis carinii pneumonia in patients with immunobullous and connective tissue disease receiving immunosuppressive medications. ( 19828210 )	Gerhart J.L....Kalaaji A.N.	2010
29	Risk of pneumocystosis after early discontinuation of prophylaxis among HIV-infected patients receiving highly active antiretroviral therapy. ( 20492660 )	Cheng C.Y....Hung C.C.	2010
30	Pneumocystis carinii pneumonia in a HIV-positive patient. ( 20726370 )	van Heese AH...Risseeuw GA	2010
31	Late-onset and atypical presentation of Pneumocystis carinii pneumonia in a renal transplant recipient. ( 18758701 )	Li JY...Coates PT	2009
32	Screening Pneumocystis carinii pneumonia in non-HIV-infected immunocompromised patients using polymerase chain reaction. ( 19631093 )	Jiancheng W...Xixiong K	2009
33	Predictors of pneumocystosis or tuberculosis in HIV-infected Asian patients with AFB smear-negative sputum pneumonia. ( 18645508 )	Le Minor O....Vray M.	2008
34	Activity of propolis in an experimental model of pneumocystosis. ( 18690302 )	Oguzkaya-Artan M....Ozturk A.	2008
35	Splenic pneumocystosis: an atypical presentation of extrapulmonary Pneumocystis infection. ( 18975440 )	O'Neal C.B....Ball S.C.	2008
36	Central retinal vein occlusion in an AIDS patient with presumed Pneumocystis carinii pneumonia. ( 18443615 )	Yeh S....Holz E.R.	2008
37	Otic pneumocystosis in acquired immune deficiency syndrome. ( 18496145 )	Mahlakwane M.S....Biyana S.	2008
38	S-adenosylmethionine levels in the diagnosis of Pneumocystis carinii pneumonia in patients with HIV infection. ( 18177224 )	Skelly MJ...Merali S	2008
39	[Pneumocystis carinii pneumonia in a patient with hyper-IgE syndrome]. ( 17554982 )	Kubota M....Kawabata Y.	2007
40	Cystic pneumocystosis in a patient with AIDS. ( 17992424 )	Molina R.J....Correia D.	2007
41	Pneumocystis carinii pneumonia in infant treated with oral steroids for hemangioma. ( 17875903 )	Maronn ML...Drolet BA	2007
42	Pneumocystis carinii pneumonia in a patient on etanercept for psoriatic arthritis. ( 17906888 )	Lahiff C...Chadwick GA	2007
43	Pneumocystis carinii pneumonia in an infant with hypogammaglobulinemia. ( 17165040 )	Cetin E...Lee EY	2007
44	Prophylaxis of Pneumocystis carinii pneumonia with atovaquone in children with leukemia. ( 17345613 )	Madden RM...Leung W	2007
45	A background and critical analysis of the treatment of pneumocystis carinii pneumonia (PCP) in HIV/AIDS. ( 17441498 )	Mitchell B	2007
46	Pneumocystis carinii pneumonia in a rheumatoid arthritis patient treated with adalimumab. ( 17464877 )	Kalyoncu U...Ertenli AI	2007
47	Pneumocystis carinii pneumonia in immunocompromised host--an autopsy report of three cases. ( 17474255 )	Valand AG...Pandya BS	2007
48	Usefulness of beta-D glucan in diagnosing Pneumocystis carinii pneumonia and monitoring its treatment in a living-donor liver-transplant recipient. ( 17520208 )	Kawagishi N...Satomi S	2007
49	Patients receiving standard-dose temozolomide therapy are at risk of Pneumocystis carinii pneumonia. ( 17644327 )	Yu SK...Chalmers AJ	2007
50	The 'dark bronchus' sign: HRCT diagnosis of Pneumocystis carinii pneumonia. ( 19724672 )	Yadav P...Sood R	2007

Sources

Genes for Pneumocystosis

Genes related to Pneumocystosis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	DHPS	Deoxyhypusine Synthase	Protein Coding	22.08	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19085210 14736212 11055650 (more) 15175932 15867494 15200857 14725329 15472859 15531210 17169018
2	CD4	CD4 Molecule	Protein Coding	22.05	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	7691271 8496763 7706901 (more) 9618388
3	DHFR	Dihydrofolate Reductase	Protein Coding	21.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	18703847 7594732
4	SFTPD	Surfactant Protein D	Protein Coding	20.8	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	11321887 11061091
5	MT-CYB	Mitochondrially Encoded Cytochrome B	Protein Coding	16.22	DISEASES inferred ¹⁵
6	ALB	Albumin	Protein Coding	15.85	DISEASES inferred ¹⁵
7	CD40LG	CD40 Ligand	Protein Coding	15.59	DISEASES inferred ¹⁵
8	GYPA	Glycophorin A (MNS Blood Group)	Protein Coding	15.42	DISEASES inferred ¹⁵
9	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	15.34	DISEASES inferred ¹⁵
10	TNF	Tumor Necrosis Factor	Protein Coding	15.22	DISEASES inferred ¹⁵
11	CLEC7A	C-Type Lectin Domain Containing 7A	Protein Coding	15.18	DISEASES inferred ¹⁵
12	TBC1D23	TBC1 Domain Family Member 23	Protein Coding	15.15	DISEASES inferred ¹⁵
13	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	14.74	DISEASES inferred ¹⁵

Sources

Variations for Pneumocystosis

Sources

Expression for Pneumocystosis

Search GEO for disease gene expression data for Pneumocystosis.

Sources

Pathways for Pneumocystosis

Pathways related to Pneumocystosis according to GeneCards Suite gene sharing:

(show all 13)

#	Super pathways	Score	Top Affiliating Genes
1	4-1BB Pathway ⁶⁵ Show member pathways CD27 Pathway ⁶⁵ CD40 Signaling ⁶⁵ CMV and MAPK Pathways ⁶⁵ NF-KappaB Activation by EBV ⁶⁵ NF-kappaB Activation by Viruses ⁶⁵ PKR Pathway ⁶⁵ SUMO Pathway ⁶⁵ TNFR2 Pathway ⁶⁵	12.3	CD4 CD40LG TNF TNFRSF1B
2	Immune response NFAT in immune response ²³ Show member pathways Immune response CD28 signaling ²³ Immune response ICOS pathway in T-helper cell ²³ Immune response T cell receptor signaling pathway ²³	12.23	CD4 CD40LG TNF TNFRSF1B
3	Apoptosis and Autophagy ⁴	11.9	CD40LG TNF TNFRSF1B
4	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	11.83	MUC1 SFTPD TNF
5	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.56	CD4 GYPA TNF
6	Interleukin-4 and 13 signaling ⁶⁷	11.49	MUC1 TNF TNFRSF1B
7	Hematopoietic cell lineage ³⁸	11.32	CD4 GYPA TNF
8	Inflammatory Response Pathway ¹	11.04	CD40LG TNFRSF1B
9	14-3-3 and Regulation of BAD Activity ⁶⁵	11.02	TNF TNFRSF1B
10	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway ²³	11	CD40LG TNF TNFRSF1B
11	Antifolate resistance ³⁸	10.99	DHFR TNF
12	Cytokines and Inflammatory Response ¹	10.94	CD4 TNF
13	Malaria ³⁸	10.49	CD40LG GYPA TNF

Sources

GO Terms for Pneumocystosis

Biological processes related to Pneumocystosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.67	CD4 CD40LG TNF TNFRSF1B
2	inflammatory response	GO:0006954	9.62	CD40LG CLEC7A TNF TNFRSF1B
3	cytokine-mediated signaling pathway	GO:0019221	9.46	CD4 MUC1 TNF TNFRSF1B
4	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.26	TNF TNFRSF1B
5	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.13	CD40LG TNF TNFRSF1B
6	regulation of immunoglobulin secretion	GO:0051023	8.62	CD40LG TNF

Molecular functions related to Pneumocystosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.73	ALB CD4 CD40LG CLEC7A DHFR DHPS
2	tumor necrosis factor receptor binding	GO:0005164	9.16	CD40LG TNF
3	identical protein binding	GO:0042802	9.1	ALB CD4 DHPS GYPA SFTPD TNF

Sources

Sources for Pneumocystosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Pneumocystosis (PCP)

Aliases & Classifications for Pneumocystosis

MalaCards integrated aliases for Pneumocystosis:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Pneumocystosis

Related Diseases for Pneumocystosis

Diseases related to Pneumocystosis via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Pneumocystosis via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Pneumocystosis:

Symptoms & Phenotypes for Pneumocystosis

MGI Mouse Phenotypes related to Pneumocystosis:

Drugs & Therapeutics for Pneumocystosis

Drugs for Pneumocystosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: pneumonia, pneumocystis

Genetic Tests for Pneumocystosis

Anatomical Context for Pneumocystosis

MalaCards organs/tissues related to Pneumocystosis:

Publications for Pneumocystosis

Articles related to Pneumocystosis:

Genes for Pneumocystosis

Genes related to Pneumocystosis (0 elite genes):

Variations for Pneumocystosis

Expression for Pneumocystosis

Pathways for Pneumocystosis

Pathways related to Pneumocystosis according to GeneCards Suite gene sharing:

GO Terms for Pneumocystosis

Biological processes related to Pneumocystosis according to GeneCards Suite gene sharing:

Molecular functions related to Pneumocystosis according to GeneCards Suite gene sharing:

Sources for Pneumocystosis

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :