Pneumocystosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

PCP MCID: PNM001 MIFTS: 60	Pneumocystosis (PCP) Categories: Infectious diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Pneumocystosis

MalaCards integrated aliases for Pneumocystosis:

Name: Pneumocystosis ¹² ⁷³ ²⁰ ⁵⁸ ¹⁵ ¹⁷ ³²

Pneumocystis Jirovecii Pneumonia ¹² ²⁰ ³

Pneumocystis Carinii Pneumonia ¹² ²⁰ ¹⁵

Pneumocystis Pneumonia ¹² ²⁰ ³

Pcp ⁴⁸ ³

Pneumocystis Jiroveci Pneumonia ⁷⁰

Pneumonia Pneumocystis Carinii ⁵⁴

Pneumocystosis Pneumonia ¹²

Pulmonary Pneumocystosis ¹²

Pneumonia, Pneumocystis ⁴⁴

Characteristics:

Orphanet epidemiological data:

⁵⁸

pneumocystosis
Inheritance: Not applicable; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Certain infectious and parasitic diseases

Protozoal diseases

Pneumocystosis

Orphanet: ⁵⁸

Rare infectious diseases

External Ids:

Disease Ontology ¹² DOID:11339

ICD9CM ³⁴ 136.3

MeSH ⁴⁴ D011020

NCIt ⁵⁰ C3334

SNOMED-CT ⁶⁷ 57541005

ICD10 ³² B59

ICD10 via Orphanet ³³ B59+ J17.3*

UMLS via Orphanet ⁷¹ C1535939

Orphanet ⁵⁸ ORPHA723

SNOMED-CT via HPO ⁶⁸ 108369006 127388009 129646001 more

EFO ¹⁷ EFO_0007448

UMLS ⁷⁰ C1535939

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Summaries for Pneumocystosis

CDC : ³ Pneumocystis pneumonia (PCP) is a serious infection caused by the fungus Pneumocystis jirovecii. Most people who get PCP have a medical condition that weakens their immune system, like HIV/AIDS, or take medicines that lower the body's ability to fight germs and sickness. In the United States, people with HIV/AIDS are less likely to get PCP today than before the availability of antiretroviral therapy (ART). However, PCP is still a substantial public health problem.1-3 Much of the information we have about PCP and its treatment comes from caring for patients with HIV/AIDS. Scientists have changed both the classification and the name of this organism since it first appeared in patients with HIV in the 1980s. Pneumocystis jirovecii used to be classified as a protozoan but is now considered a fungus.4 Pneumocystis jirovecii used to be called Pneumocystis carinii. When scientists renamed P. carinii to P. jirovecii, some people considered using the abbreviation "PJP," but to avoid confusion, Pneumocystis jirovecii pneumonia is still abbreviated "PCP."5

MalaCards based summary : Pneumocystosis, also known as pneumocystis jirovecii pneumonia, is related to immunodeficiency with hyper-igm, type 1 and oral candidiasis. An important gene associated with Pneumocystosis is DHPS (Deoxyhypusine Synthase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and bone marrow, and related phenotypes are fever and hypoxemia

Disease Ontology : ¹² An opportunistic mycosis that is located in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has material basis in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has symptom nonproductive cough, has symptom shortness of breath, and has symptom fever.

GARD : ²⁰ The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 723 Definition Human pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localised to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.

Wikipedia : ⁷³ Pneumocystosis is an infection by Pneumocystis jirovecii, that primarily occurs as a pulmonary infection... more...

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Related Diseases for Pneumocystosis

Diseases related to Pneumocystosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1074)

#	Related Disease	Score	Top Affiliating Genes
1	immunodeficiency with hyper-igm, type 1	31.9	CD8A CD40LG CD4 CCR6 BTK
2	oral candidiasis	31.1	CLEC7A CD4 CCR6 CARD9
3	nocardiosis	30.8	TNF CRP CD4
4	adult respiratory distress syndrome	30.8	TNF SFTPD IL6 CSF3
5	severe cutaneous adverse reaction	30.8	TNF CRP CD8A CD4
6	pyoderma gangrenosum	30.7	TNF CSF3 CCR6
7	posterior scleritis	30.7	TNF CRP
8	pancytopenia	30.7	IL6 DHFR CSF3 CRP CD8A CD4
9	extrinsic allergic alveolitis	30.6	SFTPD IL6 CCR6 ALB
10	autoimmune glomerulonephritis	30.6	CD8A CD4 CCR6
11	genital herpes	30.6	CD8A CD4 CCR6
12	pulmonary edema	30.6	TNF CSF3 CRP
13	scleritis	30.6	TNF CRP CCR6
14	adult t-cell leukemia	30.6	IL2 CD4 CCR6
15	pustulosis of palm and sole	30.6	TNF CRP CCR6
16	haemophilus influenzae	30.6	TNF CLEC7A
17	endocarditis	30.6	TNF IL6 CRP ALB
18	purpura	30.6	TNF IL6 CRP
19	drug allergy	30.6	CRP CD4 ALB
20	clostridium difficile colitis	30.6	CRP CCR6 ALB
21	esophageal candidiasis	30.5	CLEC7A CD8A CD4 CCR6 CARD9
22	end stage renal disease	30.5	TNF IL6 CRP ALB
23	toxoplasmosis	30.5	TNF IL6 DHFR CD40LG
24	severe acute respiratory syndrome	30.5	TNF IL6 CRP
25	pleural empyema	30.5	IL6 CRP CD4 ALB
26	disseminated intravascular coagulation	30.5	TNF IL6 CRP
27	hepatitis a	30.5	TNF CD4 ALB
28	miliary tuberculosis	30.4	TNF CSF3 CRP CD8A CD4 ALB
29	allergic disease	30.4	TNF IL6 IL2 CCR6
30	granulomatosis with polyangiitis	30.4	TNF CRP CD4 CCR6
31	iga glomerulonephritis	30.4	IL6 CD40LG CCR6 ALB
32	chronic urticaria	30.4	TNF IL6 CRP
33	chronic granulomatous disease	30.4	TNF MT-CYB CSF3 CD40LG
34	trypanosomiasis	30.4	TNF IL6 CSF3 ALB
35	t cell deficiency	30.4	IL2 CD8A CD4 CCR6
36	coccidioidomycosis	30.3	CLEC7A CD4 CCR6 CARD9
37	bacterial pneumonia	30.3	TNF SFTPD IL6 CSF3 CRP CD8A
38	substance abuse	30.3	IL6 CRP CD4 CCR6 ALB
39	urticaria	30.3	TNF IL6 CRP CD4
40	hypopyon	30.3	TNF IL6 CRP CD4
41	portal hypertension	30.3	TNF CD4 ALB
42	agammaglobulinemia, x-linked	30.3	CD40LG CD4 CCR6 BTK
43	mycobacterium tuberculosis 1	30.3	TNF CLEC7A CD8A CD4 CCR6
44	histoplasmosis	30.3	TNF CLEC7A CD8A CD4 CCR6
45	erythema multiforme	30.3	TNF IL6 IL2
46	herpes zoster	30.2	TNF IL2 DHFR CD8A CD4 CCR6
47	alcoholic hepatitis	30.2	TNF IL6 CRP ALB
48	goodpasture syndrome	30.2	CD52 CD4 CCR6 ALB
49	systemic autoimmune disease	30.2	IL6 CRP
50	marginal zone b-cell lymphoma	30.2	CD40LG CCR6 BTK

Comorbidity relations with Pneumocystosis via Phenotypic Disease Network (PDN):

Deficiency Anemia	Heart Disease
Neutropenia	Oral Candidiasis
Postinflammatory Pulmonary Fibrosis	Respiratory Failure

Graphical network of the top 20 diseases related to Pneumocystosis:

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Symptoms & Phenotypes for Pneumocystosis

Human phenotypes related to Pneumocystosis:

⁵⁸ ³¹ (show all 25)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	fever ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001945
2	hypoxemia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0012418
3	acute infectious pneumonia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0011949
4	pneumocystis jirovecii pneumonia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0020102
5	immunodeficiency ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002721
6	weight loss ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0001824
7	respiratory failure ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002878
8	respiratory failure requiring assisted ventilation ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0004887
9	pleural effusion ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002202
10	exertional dyspnea ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002875
11	interstitial pneumonitis ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0006515
12	nonproductive cough ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0031246
13	abnormal neutrophil count ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0011991
14	combined cystic and ground-glass pattern on pulmonary hrct ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0025395
15	increased circulating antibody level ³¹	frequent (33%)		HP:0010702
16	neoplasm ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002664
17	chronic oral candidiasis ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0009098
18	parenchymal consolidation ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0032177
19	multiple pulmonary cysts ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0005948
20	bloodstream infectious agent ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0031863
21	increased lactate dehydrogenase level ³¹	occasional (7.5%)		HP:0025435
22	respiratory insufficiency ⁵⁸		Frequent (79-30%)
23	dyspnea ⁵⁸		Very frequent (99-80%)
24	increased antibody level in blood ⁵⁸		Frequent (79-30%)
25	increased lactate dehydrogenase activity ⁵⁸		Occasional (29-5%)

MGI Mouse Phenotypes related to Pneumocystosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.03	BTK CARD9 CCR6 CD4 CD40LG CD8A
2	homeostasis/metabolism	MP:0005376	9.83	ALB BTK CARD9 CCR6 CD4 CD40LG
3	immune system	MP:0005387	9.55	ALB BTK CARD9 CCR6 CD4 CD40LG

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Drugs & Therapeutics for Pneumocystosis

Drugs for Pneumocystosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

6741

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

5755

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Caspofungin

Approved

Phase 4

162808-62-0, 179463-17-3

468682 2826718

Sulfisoxazole

Approved, Vet_approved

Phase 4

127-69-5

5344

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

Anti-Retroviral Agents

Phase 4

Protective Agents

Phase 4

Methylprednisolone Acetate

Phase 4

Antiemetics

Phase 4

Gastrointestinal Agents

Phase 4

Neuroprotective Agents

Phase 4

Pyrimethamine

Approved, Investigational, Vet_approved

Phase 3

58-14-0

4993

Zidovudine

Approved

Phase 3

30516-87-1

35370

Sulfadoxine

Approved, Investigational

Phase 3

2447-57-6

17134

Hydroxychloroquine

Approved

Phase 3

118-42-3

3652

Cobicistat

Approved

Phase 3

1004316-88-4

Darunavir

Approved

Phase 3

635728-49-3, 206361-99-1

213039

Fluconazole

Approved, Investigational

Phase 3

86386-73-4

3365

Posaconazole

Approved, Investigational, Vet_approved

Phase 3

171228-49-2

147912

Trimetrexate

Approved, Investigational

Phase 3

52128-35-5

5583

leucovorin

Approved

Phase 3

58-05-9

6006

Isoniazid

Approved, Investigational

Phase 2, Phase 3

54-85-3

3767

Rezafungin

Investigational

Phase 3

1396640-59-7

Pafuramidine

Investigational

Phase 3

186953-56-0

Maleic acid

Experimental

Phase 3

110-16-7

444266

Reverse Transcriptase Inhibitors

Phase 3

Antirheumatic Agents

Phase 3

Anti-HIV Agents

Phase 3

Antiviral Agents

Phase 3

Cytochrome P-450 CYP3A Inhibitors

Phase 3

HIV Protease Inhibitors

Phase 3

protease inhibitors

Phase 3

Echinocandins

Phase 3

Antimetabolites

Phase 3

Antidotes

Phase 3

Micronutrients

Phase 3

Trace Elements

Phase 3

Nutrients

Phase 3

Vitamins

Phase 3

Calcium, Dietary

Phase 3

Lipid Regulating Agents

Phase 2, Phase 3

Hypolipidemic Agents

Phase 2, Phase 3

Calcium

Nutraceutical

Phase 3

7440-70-2

271

Vitamin K1

Approved, Investigational

Phase 2

84-80-0

5284607

Ganciclovir

Approved, Investigational

Phase 1, Phase 2

82410-32-0

3454

Triamcinolone

Approved, Vet_approved

Phase 1, Phase 2

124-94-7

31307

Mycophenolic acid

Approved

Phase 1, Phase 2

24280-93-1

446541

Interventional clinical trials:

(show top 50) (show all 83)

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase IV, Randomised, Multicentre, Double-blind, Study to Evaluate the Clinical Utility of Prospective Genetic Screening (HLA-B*1301) for Susceptibility to Dapsone Hypersensitivity Syndrome	Unknown status	NCT02550080	Phase 4	Dapsone
2	Gradual Initiation of Trimethoprim/Sulfamethoxazole as Primary Pneumocystis Carinii Pneumonia Prophylaxis	Completed	NCT00000816	Phase 4	Sulfamethoxazole-Trimethoprim
3	Randomized Clinical Trial to Assess Whether the Duration of Cotrimoxazole Preventive Therapy in HIV Patients With CD4 Counts >350 CD4 Cells/µL by Antiretroviral Treatment Influences the Rate of Carriage of Multidrug-resistant Bacteria	Completed	NCT03087890	Phase 4	Cotrimoxazole;Placebo
4	A Prospective Randomized Controlled Study to Compare Efficacy of Caspofungin Combined With Trimethoprim-sulfamethoxazole Versus Trimethoprim/Sulfamethoxazole as First-line Therapy in Non-HIV Patients With Severe Pneumocystis Pneumonia	Recruiting	NCT03978559	Phase 4	caspofungin;TMP/SMZ(trimethoprim/sulfisoxazole);Methylprednisolone
5	Oral Corticosteroids Therapy and Interstitial Fibrosis in Patients With Pneumocystis Jirovecii Pneumonia (PCP) and pO2 of >70 at Presentation.	Withdrawn	NCT00636935	Phase 4	Antibiotics only;Antibiotics + Corticosteroids;Corticosteroids + antibiotics
6	The Safety and Effectiveness of Trimethoprim/Sulfamethoxazole as Pneumocystis Carinii Pneumonia (PCP) Prophylaxis in Patients With Connective Tissue Diseases	Unknown status	NCT01747278	Phase 2, Phase 3	Trimethoprim/Sulfamethoxazole
7	A Randomized, Open-Label Trial of High Dose Atovaquone Versus Low Dose Atovaquone Versus Aerosolized Pentamidine for Prophylaxis of Pneumocystis Carinii Pneumonia in Patients With HIV Infection Who Are Intolerant of TMP/SMX	Completed	NCT00002340	Phase 3	Atovaquone;Pentamidine isethionate
8	A Randomized, Comparative, Double-Blind Trial of Trimetrexate (CI-898) With Leucovorin Calcium Rescue Versus Trimethoprim / Sulfamethoxazole for Moderately Severe Pneumocystis Carinii Pneumonia in Patients With AIDS	Completed	NCT00001014	Phase 3	Trimetrexate glucuronate;Sulfamethoxazole-Trimethoprim;Leucovorin calcium
9	A Controlled Comparative Trial of Trimethoprim - Sulfamethoxazole Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT)	Completed	NCT00000727	Phase 3	Pentamidine isethionate;Pyrimethamine;Sulfamethoxazole/Trimethoprim;Sulfadoxine/Pyrimethamine;Zidovudine
10	An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies	Completed	NCT00000714	Phase 3	Trimetrexate glucuronate;Leucovorin calcium
11	A Treatment Protocol for the Use of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia and Serious Intolerance to Approved Therapies	Completed	NCT00001016	Phase 3	Trimetrexate glucuronate;Leucovorin calcium
12	A Randomized, Comparative, Double-Blind Trial of Trimetrexate (CI-898) With Leucovorin Calcium Rescue Versus Trimethoprim / Sulfamethoxazole for Moderately Severe Pneumocystis Carinii Pneumonia in Patients With AIDS	Completed	NCT00001013	Phase 3	Trimetrexate glucuronate;Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Leucovorin calcium
13	A Study of Trimetrexate With Leucovorin Rescue for AIDS Patients Who Are Refractory to Standard Therapies for Pneumocystis Carinii Pneumonia	Completed	NCT00000724	Phase 3	Trimetrexate glucuronate;Leucovorin calcium
14	A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis Pneumonia in AIDS	Completed	NCT00000715	Phase 3	Pentamidine isethionate;Sulfamethoxazole-Trimethoprim
15	A Randomized, Comparative, Prospective Study of Monthly Aerosolized Pentamidine and Thrice Weekly Dapsone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant to Trimethoprim and/or Sulfonamides	Completed	NCT00001028	Phase 3	Pentamidine isethionate;Dapsone
16	A Randomized Trial of Three Anti-Pneumocystis Agents Plus Zidovudine for the Primary Prevention of Serious Infections in Patients With Advanced HIV Infection	Completed	NCT00000991	Phase 3	Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Dapsone;Zidovudine
17	A Randomized, Comparative, Prospective Study of Daily Trimethoprim / Sulfamethoxazole (TMS) and Thrice-Weekly TMS for Prophylaxis Against PCP in HIV-Infected Patients	Completed	NCT00000748	Phase 3	Sulfamethoxazole-Trimethoprim
18	A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides	Completed	NCT00000802	Phase 3	Atovaquone;Dapsone
19	A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Trimethoprim / Sulfamethoxazole in the Treatment of Mild-to-Moderate PCP in Patients With AIDS	Completed	NCT00000640	Phase 3	Primaquine;Sulfamethoxazole-Trimethoprim;Dapsone;Clindamycin
20	Efficacy and Safety of Hydroxychloroquine for Treatment of COVID-19	Completed	NCT04261517	Phase 3	Hydroxychloroquine
21	Efficacy and Safety of Darunavir and Cobicistat for Treatment of COVID-19	Recruiting	NCT04252274	Phase 3	Darunavir and Cobicistat
22	A Phase 3, Multicenter, Randomized, Double-Blind Study of the Efficacy and Safety of Rezafungin for Injection Versus the Standard Antimicrobial Regimen to Prevent Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation (The ReSPECT Study)	Recruiting	NCT04368559	Phase 3	Rezafungin for Injection;Posaconazole;Fluconazole;Trimethoprim-sulfamethoxazole (TMP/SMX);Intravenous Placebo;Oral Placebo
23	Intérêt de la corticothérapie Dans la Pneumocystose Grave du Patient immunodéprimé Non VIH. Essai Prospectif Multicentrique Randomisé Contrôlé : PIC	Recruiting	NCT02944045	Phase 3	Methylprednisolone;Placebo
24	A Randomized, Comparative Trial of Trimetrexate With Leucovorin Rescue Versus Standard Anti-Pneumocystis Therapy Versus Standard Anti-Pneumocystis Therapy With High Dose Steroids for AIDS Patients With Pneumocystis Pneumonia Who Appear to Be Refractory to Conventional Drugs	Terminated	NCT00000730	Phase 3	Trimetrexate glucuronate;Methylprednisolone;Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Leucovorin calcium
25	International Randomized, Controlled Phase 3 Trial of DB289 Versus Trimethoprim-sulfamethoxazole for the Treatment of Acute Pneumocystis Jiroveci Pneumonia (PCP) in Patients With HIV/AIDS	Terminated	NCT00302341	Phase 3	Pafuramidine maleate (DB289);Trimethoprim-Sulfamethoxazole (TMP-SMX)
26	A Randomized, Double Blind, Placebo Controlled Trial to Determine the Efficacy of Isoniazid (INH) in Preventing Tuberculosis Disease and Latent Tuberculosis Infection Among Infants With Perinatal Exposure to HIV	Terminated	NCT00080119	Phase 2, Phase 3	Isoniazid (INH);Trimethoprim/Sulfamethoxazole (TMP/SMX);Isoniazid Placebo (PL)
27	A Controlled Randomized Trial to Study the Efficacy of Adjunctive Methylprednisolone for the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Pediatric AIDS Patients	Withdrawn	NCT00000741	Phase 3	Methylprednisolone
28	A Phase II Open Randomized Comparison of 566C80 and Pentamidine Isethionate for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients Who Are Intolerant of Trimethoprim / Sulfamethoxazole	Completed	NCT00001996	Phase 2	Atovaquone;Pentamidine isethionate
29	A Phase II Study of WR 6026 for Pneumocystis Carinii Pneumonia in People With HIV Infection	Completed	NCT00000863	Phase 2	Sitamaquine
30	A Randomized, Double-Blind Study of 566C80 Versus Septra (Trimethoprim/Sulfamethoxazole) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients	Completed	NCT00000655	Phase 2	Atovaquone;Sulfamethoxazole-Trimethoprim
31	Randomized, Multi-Center Comparative Trial of Tacrolimus w/Steroids and Standard Daclizumab Induction vs a Novel Steroid-Free Tacrolimus Based Immunosuppression Protocol w/ Extended Daclizumab Induction in Pediatric Renal Transplantation	Completed	NCT00141037	Phase 1, Phase 2	Daclizumab;Mycophenolate mofetil (MMF);Prednisone;Tacrolimus;Ganciclovir;Valganciclovir;Trimethoprim and sulfamethoxazole
32	A Randomized, Phase II/III, Double-Blind, Two-Armed Study of Micronized Atovaquone and Azithromycin (AT/AZ) as Compared to Trimethoprim-Sulfamethoxazole (TMP/SMX) in the Prevention of Serious Bacterial Infections When Used in Children Aged 3 Months to 19 Years With HIV Infection	Completed	NCT00000811	Phase 2	Azithromycin;Atovaquone;Sulfamethoxazole-Trimethoprim
33	Randomized Phase I Study of Trimetrexate Glucuronate (TMTX) With Leucovorin (LCV) Protection Plus Dapsone Versus Trimethoprim / Sulfamethoxazole (TMP/SMX) for Treatment of Moderately Severe Episodes of Pneumocystis Carinii Pneumonia	Completed	NCT00002120	Phase 1	Trimetrexate glucuronate;Trimethoprim;Sulfamethoxazole;Dapsone;Leucovorin calcium
34	A Phase I Study of the Safety, Tolerance, and Study of the Pharmacokinetics of Aerosolized Pentamidine and Parenteral Pentamidine in Children With HIV Infection and Suspected Pneumocystis Carinii Pneumonia	Completed	NCT00000974	Phase 1	Pentamidine isethionate
35	Comparison of Two Dosage Regimens of Oral Dapsone for Prophylaxis of Pneumocystis Carinii Pneumonia in Pediatric HIV Infection	Completed	NCT00000739	Phase 1	Dapsone
36	Evaluation of Escalating Doses of Intravenous Trimetrexate as Therapy for Previously Untreated Pneumocystis Carinii Pneumonia in AIDS Patients With Subsequent Comparison of Intravenous and Oral Pharmacokinetics	Completed	NCT00000998	Phase 1	Trimetrexate glucuronate;Leucovorin calcium
37	A Phase I/II Trial of Parenteral Pentamidine for PCP Prophylaxis in HIV-Infected Children Who Are Intolerant to Oral Trimethoprim-Sulfamethoxazole	Completed	NCT00001027	Phase 1	Pentamidine isethionate
38	Phase I Safety and Pharmacokinetics Study of Microparticulate Atovaquone (m-Atovaquone; 566C80) in HIV-Infected and Perinatally Exposed Infants and Children	Completed	NCT00000773	Phase 1	Atovaquone
39	Escalating Multiple-Dose Safety and Tolerance of WR 6026 Hydrochloride in HIV-Infected Subjects	Completed	NCT00000740	Phase 1	Sitamaquine
40	A Pharmacokinetic and Pharmacogenetic Study in Patients Receiving Sulfamethoxazole-trimethoprim Therapy	Unknown status	NCT02045160
41	Prospective Registration of Severe Pneumocystis Jiroveci Pneumonia Requiring ICU	Unknown status	NCT03201497
42	Characterization of Fungal Infections in COVID-19 Infected and Mechanically Ventilated Patients in ICU	Completed	NCT04368221
43	Clindamycin - Trimethoprim/Sulfamethoxazole for Pneumocystis Jiroveci Pneumonia After Solid Organ Transplantation Population (CTSTOP)	Completed	NCT04328688
44	A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate (Neutrexin) With Leucovorin Protection for European Adult Patients (>= 13 Years Old) With Pneumocystis Carinii Pneumonia	Completed	NCT00002103		Trimetrexate glucuronate;Leucovorin calcium
45	A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate With Leucovorin Protection for Patients With Pneumocystis Carinii Pneumonia.	Completed	NCT00002102		Trimetrexate glucuronate;Leucovorin calcium
46	A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral / Oral Trimethoprim - Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia in AIDS	Completed	NCT00002056		Pentamidine isethionate
47	A Double-Blind Group Comparative Study To Evaluate the Long-Term Safety and Effectiveness of Two Different Doses of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients With Multiple Episodes of PCP	Completed	NCT00002055		Pentamidine isethionate
48	A Double-Blind Study To Evaluate the Long-Term Safety and Effectiveness of 60 mg Versus 120 mg of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients	Completed	NCT00002054		Pentamidine isethionate
49	A Double-Blind Placebo-Controlled Group Comparative Study To Evaluate the Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in Patients With AIDS Post First Episode PCP	Completed	NCT00002053		Pentamidine isethionate
50	Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC)	Completed	NCT00002043		Dapsone

Search NIH Clinical Center for Pneumocystosis

Inferred drug relations via UMLS ⁷⁰ / NDF-RT ⁵¹ :

Atovaquone

CLINDAMYCIN PHOSPHATE PWDR

Pentamidine

Pentamidine Isethionate

Sulfadoxine

TRIMETHOPRIM SULFATE

Trimetrexate

Cochrane evidence based reviews: pneumonia, pneumocystis

Sources

Genetic Tests for Pneumocystosis

Sources

Anatomical Context for Pneumocystosis

MalaCards organs/tissues related to Pneumocystosis:

⁴⁰

Lung, Kidney, Bone Marrow, Bone, Skin, Small Intestine, Spleen

Sources

Publications for Pneumocystosis

Articles related to Pneumocystosis:

(show top 50) (show all 2218)

#	Title	Authors	PMID	Year
1	Absence of Pneumocystis jirovecii dihydropteroate synthase gene mutations among samples from a group of AIDS patients in China. ⁶¹ ⁵⁴	Li K...Zhan XM	19085210	2009
2	Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine. ⁵⁴ ⁶¹	Cody V...Rosowsky A	18703847	2008
3	Caspase-9 as a target for Pneumocystis pneumonia therapy. ⁵⁴ ⁶¹	Lasbury ME...Lee CH	17169033	2006
4	Pneumocystosis: survey and DHPS genotype analysis in 14 Parisian hospitals in 2003 and 2004. ⁶¹ ⁵⁴	Magne D...Roux P	17169018	2006
5	Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations. ⁵⁴ ⁶¹	Crothers K...Huang L	15867494	2005
6	Cloning of the Pneumocystis jirovecii trifunctional FAS gene and complementation of its DHPS activity in Escherichia coli. ⁵⁴ ⁶¹	Iliades P...Macreadie IG	15531210	2004
7	Pneumocystis jiroveci isolates with dihydropteroate synthase mutations in patients with chronic bronchitis. ⁵⁴ ⁶¹	Calderon E...Varela JM	15175932	2004
8	Pneumocystis jirovecii dihydropteroate synthase genotypes in immunocompetent infants and immunosuppressed adults, Amiens, France. ⁵⁴ ⁶¹	Totet A...Nevez G	15200857	2004
9	Pneumocystis jirovecii dihydropteroate synthase genotypes in French patients with pneumocystosis: a 1998-2001 prospective study. ⁶¹ ⁵⁴	Latouche S...Roux P	14725329	2003
10	Multilocus genotyping of Pneumocystis jirovecii in patients developing diverse forms of parasitism: implication for a wide human reservoir for the fungus. ⁵⁴ ⁶¹	Totet A...Nevez G	14736212	2003
11	Pneumocystis carinii pneumonia in a term newborn infant with a transiently depressed T lymphocyte count, primarily of cells carrying the CD4 antigen. ⁶¹ ⁵⁴	Hostoffer RW...Tosi MF	8496763	1993
12	Blood urea nitrogen-to-serum albumin ratio and A-DROP are useful in assessing the severity of Pneumocystis pneumonia in patients without human immunodeficiency virus infection. ⁶¹	Akahane J...Hanaoka M	33376033	2021
13	Caspofungin combined with TMP/SMZ as a first-line therapy for moderate-to-severe PCP in patients with human immunodeficiency virus infection. ⁶¹	Tian Q...Zhao T	33277811	2021
14	Risk factors associated with increased discontinuation rate of trimethoprim-sulfamethoxazole used as a primary prophylaxis for Pneumocystis pneumonia: A retrospective cohort study. ⁶¹	Otani T...Hattori N	33571651	2021
15	Adverse effects of trimethoprim-sulfamethoxazole for the prophylaxis of Pneumocystis pneumonia in dermatology. ⁶¹	Kokubu H...Fujimoto N	33492693	2021
16	Role of Serum (1,3)-Β-D-Glucan to Screen for Pneumocystis Pneumonia in Kidney Transplant Recipients. ⁶¹	Tandukar S...Shokouh-Amiri HM	32928557	2021
17	The diagnostic challenge of pneumocystis pneumonia and COVID-19 co-infection in HIV. ⁶¹	Broadhurst AGB...Allwood BW	33664959	2021
18	Antimicrobial prophylaxis in patients with immune thrombocytopenia treated with rituximab: a retrospective multicenter analysis. ⁶¹	Raso S...Siragusa S	33495923	2021
19	Genomic insights into the host specific adaptation of the Pneumocystis genus. ⁶¹	Cisse OH...Kovacs JA	33686174	2021
20	Pneumocystis pneumonia: An important consideration when investigating artificial intelligence-based methods in the radiological diagnosis of COVID-19. ⁶¹	Lampejo T	33810937	2021
21	Estimation of treatment and prognostic factors of pneumocystis pneumonia in patients with connective tissue diseases. ⁶¹	Ishikawa Y...Tanaka Y	33688083	2021
22	Direct and indirect evidence of efficacy and safety of rapid exercise tests for exertional desaturation in Covid-19: a rapid systematic review. ⁶¹	Kalin A...Greenhalgh T	33726854	2021
23	Estimates of serious fungal infection burden in Côte d'Ivoire and country health profile. ⁶¹	Koffi D...Denning DW	33259981	2021
24	A nationwide study on inpatient opportunistic infections in patients with chronic lymphocytic leukemia in the pre-ibrutinib era. ⁶¹	Steingrimsson V...Kristinsson SY	33211356	2021
25	Efficacy of Rezafungin in Prophylactic Mouse Models of Invasive Candidiasis, Aspergillosis, and Pneumocystis Pneumonia. ⁶¹	Miesel L...Ong V	33318018	2021
26	A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil. ⁶¹	Dantas KC...Saldiva PHN	33597620	2021
27	Exploring genetic defects in adults who were clinically diagnosed as severe combined immune deficiency during infancy. ⁶¹	Somekh I...Somech R	33599911	2021
28	The impact of COVID-19 pandemic on AIDS-related mycoses and fungal neglected tropical diseases: Why should we worry? ⁶¹	Nargesi S...Hedayati MT	33561159	2021
29	Bispecific antibody therapy, its use and risks for infection: Bridging the knowledge gap. ⁶¹	Longhitano AP...Teh BW	33676765	2021
30	A proposal for pragmatic investigation of possible clonal clusters of pneumocystis pneumonia cases. ⁶¹	Nevez G...Le Gal S	33271216	2021
31	Intravenous immunoglobulin as adjunctive therapy in kidney transplant recipients with severe pneumocystis pneumonia. ⁶¹	Edey MM...Imran M	32869412	2021
32	Pneumocystis Pneumonia: Immunity, Vaccines, and Treatments. ⁶¹	Gingerich AD...Mousa JJ	33669726	2021
33	[Dihydropteroate Synthase (DHPS) Gene Mutations and Mitochondrial Large Subunit (mtLSU) rRNA Genotype Variations in Pneumocystis jirovecii Strains]. ⁶¹	Gulbudak H...Tezcan Ulger S	33590980	2021
34	COVID-19 and its Mimics: What the Radiologist Needs to Know. ⁶¹	Hanfi SH...Kotecha HM	32852419	2021
35	Toward a humanized mouse model of Pneumocystis pneumonia. ⁶¹	Dai G...Kolls JK	33491669	2021
36	Pneumocystis pneumonia with hypogammaglobulinemia in a pediatric patient who underwent heart transplantation. ⁶¹	Takajo D...Aggarwal S	33470002	2021
37	Pneumocystis Pneumonia: Still a serious disease in children. ⁶¹	Zakrzewska M...Maciorkowska E	33759428	2021
38	Fine-needle aspiration of granulomatous pneumocystosis. ⁶¹	Satturwar S...Pantanowitz L	32621323	2021
39	[Pneumocystis pneumonia and HIV infection in two patients suspected with COVID-19]. ⁶¹	Borchmann O...Hansen AE	33491631	2021
40	[Early recurrence of pneumocystis pneumonia post trimethoprim-sulfamethoxazole therapy that developed after chemotherapy for follicular lymphoma]. ⁶¹	Kikuchi T...Mori T	33551424	2021
41	Clinically amyopathic dermatomyositis presenting with isolated facial edema complicated by acute respiratory failure: a case report. ⁶¹	Lim DH...Lee S	33509162	2021
42	[Spontaneous resolution of refractory ascites in the late phase after cord blood transplantation in acute myeloid leukemia]. ⁶¹	Kawamura T...Kimura F	33551420	2021
43	Increased mRNA expression of key cytokines among suspected cases of Pneumocystis jirovecii infection. ⁶¹	Alshahrani MY...Hamid ME	33413198	2021
44	Pneumocystis jirovecii pneumonia in diffuse large B-cell Lymphoma treated with R-CHOP. ⁶¹	Lee JY...Lee JO	32970331	2021
45	X-linked CD40 ligand deficiency in a 1-year-old male Shih Tzu with secondary Pneumocystis pneumonia. ⁶¹	Merrill K...Reinero C	33274522	2021
46	[The spectrum of pathogens in 187 cases of pulmonary fungal disease diagnosed by histopathology-a retrospective analysis]. ⁶¹	Wang CP...Feng RE	33412621	2021
47	Characteristics and outcome according to underlying disease in non-AIDS patients with acute respiratory failure due to Pneumocystis pneumonia. ⁶¹	Burghi G...Lemiale V	33411170	2021
48	Efficacy and safety of trimethoprim-sulfamethoxazole for the prevention of pneumocystis pneumonia in human immunodeficiency virus-negative immunodeficient patients: A systematic review and meta-analysis. ⁶¹	Li R...Yang M	33765022	2021
49	Chest complications in immunocompromised patients without acquired immunodeficiency syndrome (AIDS): differentiation between infectious and non-infectious diseases using high-resolution CT findings. ⁶¹	Tanaka N...Matsumoto T	32859382	2021
50	Clinical effectiveness of iguratimod based on real-world data of patients with rheumatoid arthritis. ⁶¹	Mizutani S...Yasuoka H	32506311	2021

Sources

Genes for Pneumocystosis

Genes related to Pneumocystosis (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	DHPS	Deoxyhypusine Synthase	Protein Coding	21.94	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19085210 14736212 11055650 (more) 15175932 15867494 15200857 14725329 15472859 15531210 17169018
2	SFTPD	Surfactant Protein D	Protein Coding	11.67	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11321887 11061091
3	DHFR	Dihydrofolate Reductase	Protein Coding	11.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	18703847 7594732
4	CD4	CD4 Molecule	Protein Coding	11.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	7691271 8496763
5	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	8.44	DISEASES inferred ¹⁵ ¹⁵
6	CD8A	CD8a Molecule	Protein Coding	7.18	DISEASES inferred ¹⁵
7	CRP	C-Reactive Protein	Protein Coding	6.49	DISEASES inferred ¹⁵
8	CLEC7A	C-Type Lectin Domain Containing 7A	Protein Coding	6.48	DISEASES inferred ¹⁵
9	TNF	Tumor Necrosis Factor	Protein Coding	6.4	DISEASES inferred ¹⁵
10	MT-CYB	Mitochondrially Encoded Cytochrome B	Protein Coding	6.4	DISEASES inferred ¹⁵
11	ALB	Albumin	Protein Coding	6.39	DISEASES inferred ¹⁵
12	CSF3	Colony Stimulating Factor 3	Protein Coding	6.3	DISEASES inferred ¹⁵
13	CD40LG	CD40 Ligand	Protein Coding	6.27	DISEASES inferred ¹⁵
14	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	6.11	DISEASES inferred ¹⁵
15	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	5.95	DISEASES inferred ¹⁵
16	IL6	Interleukin 6	Protein Coding	5.89	DISEASES inferred ¹⁵
17	CLEC4E	C-Type Lectin Domain Family 4 Member E	Protein Coding	5.88	DISEASES inferred ¹⁵
18	CD52	CD52 Molecule	Protein Coding	5.88	DISEASES inferred ¹⁵
19	BTK	Bruton Tyrosine Kinase	Protein Coding	5.87	DISEASES inferred ¹⁵
20	IL2	Interleukin 2	Protein Coding	5.85	DISEASES inferred ¹⁵
21	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	5.85	DISEASES inferred ¹⁵

Sources

Variations for Pneumocystosis

Sources

Expression for Pneumocystosis

Search GEO for disease gene expression data for Pneumocystosis.

Sources

Pathways for Pneumocystosis

Pathways related to Pneumocystosis according to GeneCards Suite gene sharing:

(show all 34)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.89	TNF MUC1 IL6 IL2 CSF3 CRP
2	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.78	TNF MUC1 IL6 IL2 CSF3 CD40LG
3	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.36	TNF IL6 IL2 CSF3 CD40LG CD4
4	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.32	TNF MUC1 IL6 IL2 CSF3 CD40LG
5	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.25	TNF IL6 IL2 CSF3 CD40LG CD4
6	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.81	TNF IL6 IL2 CD8A CD40LG CD4
7	Immune response NFAT in immune response ²³ Show member pathways Immune response CD28 signaling ²³ Immune response ICOS pathway in T-helper cell ²³ Immune response T cell receptor signaling pathway ²³	12.59	TNF IL2 CD40LG CD4 BTK
8	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.56	TNF IL6 IL2 CD8A CD40LG CD4
9	NF-kappaB Signaling ⁴	12.5	TNF IL2 CD8A CD40LG CARD9 BTK
10	Human T-cell leukemia virus 1 infection ³⁶	12.29	TNF IL6 IL2 CD4
11	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.28	TNF IL6 IL2 CCR6
12	Tuberculosis ³⁶	12.21	TNF IL6 CLEC7A CLEC4E CARD9
13	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁵ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.18	TNF IL6 IL2 DHFR CRP ALB
14	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	12.14	TNF SFTPD MUC1 IL6
15	Yersinia infection ³⁶	12.01	TNF IL6 IL2 CD8A CD4
16	Hematopoietic cell lineage ³⁶	11.8	TNF IL6 CSF3 CD8A CD4
17	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.75	TNF IL6 IL2 CD4
18	C-type lectin receptor signaling pathway ³⁶ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁴	11.74	TNF IL6 IL2 CLEC7A CLEC4E CARD9
19	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.71	TNF IL2 CD40LG
20	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.7	TNF IL6 IL2 CSF3 CD8A CD4
21	IgA-Producing B Cells in the Intestine ⁶⁴	11.67	TNF IL6 CD40LG CCR6
22	Lung fibrosis ¹	11.62	TNF IL6 CSF3
23	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.62	TNF IL6 IL2 CD40LG
24	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.62	TNF IL2 CD8A CD4 CCR6
25	Downstream signaling in naive CD8+ T cells ¹ Show member pathways Ras signaling in the CD4+ TCR pathway ¹	11.6	TNF IL2 CD8A
26	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.52	TNF IL6 IL2 CD8A CD4
27	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.51	TNF IL6 IL2
28	Interleukin-10 signaling ⁶⁵	11.49	TNF IL6 CSF3
29	Malaria ³⁶	11.49	TNF IL6 CSF3 CD40LG
30	Primary immunodeficiency ³⁶	11.31	CD8A CD40LG CD4 BTK
31	Antifolate resistance ³⁶	11.27	TNF IL6 DHFR
32	Overview of nanoparticle effects ¹	11.03	TNF IL6 CRP
33	G-protein signaling_Rap2B regulation pathway ²³	10.99	TNF IL6 IL2 CSF3 CD40LG BTK
34	Cytokines and Inflammatory Response ¹	10.48	TNF IL6 IL2 CSF3 CD4

Sources

GO Terms for Pneumocystosis

Cellular components related to Pneumocystosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.61	TNF SFTPD MUC1 IL6 IL2 CSF3
2	external side of plasma membrane	GO:0009897	9.55	TNF CD8A CD40LG CD4 CCR6
3	extracellular region	GO:0005576	9.36	TNF SFTPD MUC1 IL6 IL2 CSF3

Biological processes related to Pneumocystosis according to GeneCards Suite gene sharing:

(show all 27)

#	Name	GO ID	Score	Top Affiliating Genes
1	innate immune response	GO:0045087	10	SFTPD CRP CLEC7A CLEC4E CARD9 BTK
2	inflammatory response	GO:0006954	9.98	TNF IL6 CRP CLEC7A CD40LG
3	immune system process	GO:0002376	9.92	SFTPD IL2 CLEC7A CLEC4E CD8A CD4
4	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.86	TNF IL6 CD40LG BTK
5	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.81	TNF IL6 IL2
6	positive regulation of interferon-gamma production	GO:0032729	9.79	TNF IL2 CLEC7A
7	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.79	TNF CARD9 BTK
8	positive regulation of interleukin-8 production	GO:0032757	9.77	TNF IL6 CLEC7A
9	humoral immune response	GO:0006959	9.77	TNF IL6 CCR6
10	defense response to Gram-positive bacterium	GO:0050830	9.76	TNF IL6 CRP CARD9
11	positive regulation of interleukin-1 beta production	GO:0032731	9.75	TNF IL6 CLEC7A
12	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0043280	9.74	TNF CLEC7A CARD9
13	cytokine-mediated signaling pathway	GO:0019221	9.73	TNF MUC1 IL6 IL2 CSF3 CD4
14	positive regulation of phagocytosis	GO:0050766	9.72	TNF SFTPD CLEC7A
15	T cell activation	GO:0042110	9.71	CLEC7A CD8A CD4
16	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.71	IL6 CSF3 CLEC7A CD4
17	positive regulation of interleukin-6 production	GO:0032755	9.67	TNF IL6 CLEC7A CARD9
18	positive regulation of interleukin-10 production	GO:0032733	9.65	IL6 CLEC7A CD40LG
19	regulation of immunoglobulin production	GO:0002637	9.63	TNF CD40LG
20	response to peptidoglycan	GO:0032494	9.62	IL6 CARD9
21	vascular endothelial growth factor production	GO:0010573	9.61	TNF IL6
22	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.61	TNF IL6 CLEC7A
23	immune response	GO:0006955	9.56	TNF IL6 IL2 CSF3 CD8A CD40LG
24	cellular response to molecule of fungal origin	GO:0071226	9.51	CLEC7A BTK
25	leukocyte activation involved in immune response	GO:0002366	9.49	IL2 CLEC7A
26	negative regulation of lipid storage	GO:0010888	9.33	TNF IL6 CRP
27	positive regulation of T cell proliferation	GO:0042102	9.02	IL6 IL2 DHPS CD40LG CD4

Molecular functions related to Pneumocystosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	carbohydrate binding	GO:0030246	9.26	SFTPD IL2 CLEC7A CLEC4E
2	cytokine activity	GO:0005125	9.02	TNF IL6 IL2 CSF3 CD40LG

Sources

Sources for Pneumocystosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Pneumocystosis (PCP)

Aliases & Classifications for Pneumocystosis

MalaCards integrated aliases for Pneumocystosis:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Pneumocystosis

Related Diseases for Pneumocystosis

Diseases related to Pneumocystosis via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Pneumocystosis via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Pneumocystosis:

Symptoms & Phenotypes for Pneumocystosis

Human phenotypes related to Pneumocystosis:

MGI Mouse Phenotypes related to Pneumocystosis:

Drugs & Therapeutics for Pneumocystosis

Drugs for Pneumocystosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 70 / NDF-RT 51 :

Cochrane evidence based reviews: pneumonia, pneumocystis

Genetic Tests for Pneumocystosis

Anatomical Context for Pneumocystosis

MalaCards organs/tissues related to Pneumocystosis:

Publications for Pneumocystosis

Articles related to Pneumocystosis:

Genes for Pneumocystosis

Genes related to Pneumocystosis (0 elite genes):

Variations for Pneumocystosis

Expression for Pneumocystosis

Pathways for Pneumocystosis

Pathways related to Pneumocystosis according to GeneCards Suite gene sharing:

GO Terms for Pneumocystosis

Cellular components related to Pneumocystosis according to GeneCards Suite gene sharing:

Biological processes related to Pneumocystosis according to GeneCards Suite gene sharing:

Molecular functions related to Pneumocystosis according to GeneCards Suite gene sharing:

Sources for Pneumocystosis

Inferred drug relations via UMLS ⁷⁰ / NDF-RT ⁵¹ :