PCP
MCID: PNM001
MIFTS: 58

Pneumocystosis (PCP)

Categories: Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Pneumocystosis

MalaCards integrated aliases for Pneumocystosis:

Name: Pneumocystosis 12 77 54 60 15 17
Pneumocystis Carinii Pneumonia 12 15
Pneumocystis Pneumonia 12 3
Pcp 49 3
Pneumocystis Jirovecii Pneumonia 12
Pneumocystis Jiroveci Pneumonia 74
Pneumonia Pneumocystis Carinii 56
Pneumocystosis Pneumonia 12
Pulmonary Pneumocystosis 12
Pneumonia, Pneumocystis 45

Characteristics:

Orphanet epidemiological data:

60
pneumocystosis
Inheritance: Not applicable; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11339
ICD9CM 36 136.3
MeSH 45 D011020
NCIt 51 C3334
SNOMED-CT 69 57541005 88860002
ICD10 34 B59
ICD10 via Orphanet 35 B59+ J17.3*
UMLS via Orphanet 75 C1535939
Orphanet 60 ORPHA723
UMLS 74 C1535939

Summaries for Pneumocystosis

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 723Disease definitionHuman pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localised to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.Visit the Orphanet disease page for more resources.

MalaCards based summary : Pneumocystosis, also known as pneumocystis carinii pneumonia, is related to respiratory failure and acquired immunodeficiency syndrome. An important gene associated with Pneumocystosis is DHPS (Deoxyhypusine Synthase), and among its related pathways/superpathways are 4-1BB Pathway and Immune response NFAT in immune response. The drugs Bupropion and Sertraline have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An opportunistic mycosis that is located in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has material basis in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has symptom nonproductive cough, has symptom shortness of breath, and has symptom fever.

CDC : 3 Pneumocystis pneumonia (PCP) is a serious infection caused by the fungus Pneumocystis jirovecii.

Wikipedia : 77 Pneumocystosis is an infection by Pneumocystis jirovecii, that primarily occurs as a pulmonary infection... more...

Related Diseases for Pneumocystosis

Diseases related to Pneumocystosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)
# Related Disease Score Top Affiliating Genes
1 respiratory failure 31.1 ALB SFTPD TNF
2 acquired immunodeficiency syndrome 30.6 ALB CD4 TNF
3 toxoplasmosis 30.6 CD40LG DHFR TNF
4 connective tissue disease 30.4 CD40LG MUC1 SFTPD TNF
5 cryptosporidiosis 30.3 CD40LG DHFR
6 pneumonia 30.2 CD40LG DHPS SFTPD TNF
7 schistosomiasis 30.1 ALB CD40LG TNF
8 vasculitis 30.1 CD40LG TNF TNFRSF1B
9 interstitial lung disease 30.0 MUC1 SFTPD TNF
10 aspergillosis 30.0 CLEC7A SFTPD TNF
11 hepatitis e 29.9 ALB CD40LG TNF
12 pulmonary fibrosis, idiopathic 29.9 MUC1 SFTPD TNF
13 hematopoietic stem cell transplantation 29.7 CLEC7A TNF
14 phencyclidine abuse 11.9
15 immunodeficiency with hyper-igm, type 1 11.8
16 human immunodeficiency virus infectious disease 10.8
17 leukemia 10.7
18 pneumothorax 10.7
19 arthritis 10.6
20 rheumatoid arthritis 10.6
21 encephalitis 10.6
22 systemic lupus erythematosus 10.5
23 lupus erythematosus 10.5
24 bacterial pneumonia 10.5
25 lymphocytic leukemia 10.5
26 cytomegalovirus infection 10.5
27 breast cancer 10.5
28 pneumothorax, primary spontaneous 10.5
29 lymphoma 10.5
30 colitis 10.5
31 ulcerative colitis 10.4
32 agammaglobulinemia 10.4
33 pulmonary tuberculosis 10.4
34 human immunodeficiency virus type 1 10.4
35 leukemia, acute lymphoblastic 10.4
36 sarcoma 10.4
37 conn's syndrome 10.4
38 myeloma, multiple 10.3
39 asthma 10.3
40 pancytopenia 10.3
41 tropical calcific pancreatitis 10.3
42 hypersplenism 10.3 ALB CD4
43 neuroblastoma 10.3
44 west syndrome 10.3
45 lung disease 10.3
46 hemophilia 10.3
47 cytomegalic inclusion disease 10.3
48 fournier gangrene 10.3 ALB CD40LG
49 pleuroparenchymal fibroelastosis 10.3 MUC1 SFTPD
50 acute interstitial pneumonia 10.3 MUC1 SFTPD

Comorbidity relations with Pneumocystosis via Phenotypic Disease Network (PDN):


Deficiency Anemia Heart Disease
Neutropenia Oral Candidiasis
Postinflammatory Pulmonary Fibrosis Respiratory Failure

Graphical network of the top 20 diseases related to Pneumocystosis:



Diseases related to Pneumocystosis

Symptoms & Phenotypes for Pneumocystosis

MGI Mouse Phenotypes related to Pneumocystosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 CD4 CD40LG CLEC7A DHFR DHPS SFTPD
2 homeostasis/metabolism MP:0005376 9.85 ALB CD4 CD40LG CLEC7A DHFR DHPS
3 immune system MP:0005387 9.61 CD4 CD40LG CLEC7A DHFR DHPS SFTPD
4 mortality/aging MP:0010768 9.28 ALB CD4 CD40LG CLEC7A DHFR DHPS

Drugs & Therapeutics for Pneumocystosis

Drugs for Pneumocystosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 392)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupropion Approved Phase 4,Not Applicable 34841-39-9, 34911-55-2 444
2
Sertraline Approved Phase 4,Not Applicable 79617-96-2 68617
3
Sulfamethoxazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 723-46-6 5329
4
Trimethoprim Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 738-70-5 5578
5
leucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 6006 143
6
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
8
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
10
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
11
Pentamidine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 100-33-4 4735
12
Budesonide Approved Phase 4,Not Applicable 51333-22-3 63006 5281004
13
Phentermine Approved, Illicit Phase 4 122-09-8 4771
14
Topiramate Approved Phase 4 97240-79-4 5284627
15
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
16
Heparin Approved, Investigational Phase 4,Phase 1 9005-49-6 772 46507594
17
Dalteparin Approved Phase 4,Phase 1 9005-49-6
18
Micafungin Approved, Investigational Phase 4 235114-32-6 477468 3081921
19
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702
20
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
21
Metronidazole Approved Phase 4,Not Applicable 443-48-1 4173
22
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
23
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
24 Strawberry Approved Phase 4
25
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
26
Nevirapine Approved Phase 4 129618-40-2 4463
27
Emtricitabine Approved, Investigational Phase 4,Phase 1,Phase 2 143491-57-0 60877
28
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 1 155213-67-5 392622
29
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
30
Methylphenidate Approved, Investigational Phase 4,Phase 1 113-45-1 4158
31
Dapsone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 80-08-0 2955
32
Primaquine Approved Phase 4,Phase 3,Not Applicable 90-34-6 4908
33
Prednisone Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 53-03-2 5865
34
Clindamycin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 18323-44-9 29029
35
Atovaquone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 95233-18-4 74989
36
Morphine Approved, Investigational Phase 4,Phase 1,Not Applicable 57-27-2 5288826
37
Naproxen Approved, Vet_approved Phase 4 22204-53-1 156391 1302
38
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
39
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
40
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
41
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
42
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
43
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
44
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Not Applicable 7440-70-2 271
45
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
46
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
47
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
48 Antidepressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Neurotransmitter Uptake Inhibitors Phase 4
50 Psychotropic Drugs Phase 4,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 543)
# Name Status NCT ID Phase Drugs
1 Depression Care Management for Depressed Elders in China Primary Care Unknown status NCT01287494 Phase 4 Sertraline
2 Gradual Initiation of Sulfamethoxazole/Trimethoprim as Primary Pneumocystis Carinii Pneumonia Prophylaxis Completed NCT00000816 Phase 4 Sulfamethoxazole-Trimethoprim
3 Evaluation of LEVITRA to Advance the Treatment of Erectile Dysfunction Completed NCT00664833 Phase 4
4 Effect of Weight and/or Obesity on Sulfamethoxazole and Trimethoprim Concentrations Completed NCT01167452 Phase 4 Sulfamethoxazole/trimethoprim
5 A Toolbox Approach to Obesity Treatment in Primary Care Completed NCT01922934 Phase 4 Obesity pharmacotherapy
6 Immediate Versus Deferred Antiretroviral Therapy in HIV-infected Patients Presenting With Acute AIDS-defining Events Completed NCT01417949 Phase 4
7 EMD and/or Bone Substitute for the Treatment of Class II Furcations Completed NCT02474498 Phase 4 EMD
8 Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy. Completed NCT02487186 Phase 4 Doxicicline
9 Primary Care Intervention Strategy for Anxiety Disorders Completed NCT00347269 Phase 4 Psychotropic medication optimization
10 Deferment of Imaging for Pulmonary Embolism Completed NCT00381511 Phase 4 low molecular weight heparin
11 Pharmacokinetics of Micafungin During Continuous Venovenous Hemofiltration Completed NCT02651038 Phase 4 Micafungin
12 Biomarker Study of Acamprosate in Schizophrenia Completed NCT00688324 Phase 4 Acamprosate
13 The Use of Erythritol Powder and Metronidazole Gel for the Non-surgical Treatment of Periodontitis Completed NCT02023840 Phase 4 metronidazole gel;placebo
14 Acute Otitis Media (AOM) Therapy Trial in Young Children Completed NCT00377260 Phase 4 amoxicillin-clavulanate;Placebo
15 VITamine D Supplementation in RenAL Transplant Recipients - VITALE Completed NCT01431430 Phase 4 Cholecalciferol 100 000 UI;Cholecalciferol 12 000 UI
16 A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation Completed NCT00048165 Phase 4 Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
17 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
18 Methylphenidate Treatment of Attention Deficits in Epilepsy Completed NCT02178995 Phase 4 Methylphenidate
19 Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria Recruiting NCT03087890 Phase 4 Cotrimoxazole;Placebo
20 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
21 A Prospective Evaluation of Natriuretic Peptide Based Referral of CHF Patients in Primary Care Recruiting NCT02807857 Phase 4
22 A Prospective Cohort Study to Improve HCV Care in Dialysis Patients Not yet recruiting NCT03791814 Phase 4 Zepatier
23 Improving Health Outcomes of Migraine Patients Who Present to the Emergency Department Not yet recruiting NCT02945839 Phase 4 Preventative Medication (PM)
24 Approaches To Therapy Escalation In T2D Not yet recruiting NCT03813316 Phase 4 DPP-4 inhibitor;SGLT2 inhibitor;SGLT2 inhibitor and DPP-4 inhibitor
25 Dissemination of Prostate Cancer Screening to PCP's in African American Communities Terminated NCT00629330 Phase 4
26 Conversion to Embeda With Rescue Trial Terminated NCT01179191 Phase 4 morphine sulfate and naltrexone hydrochloride (EMBEDA)
27 Correcting Anemia and Native Vitamin D Supplementation in Kidney Transplant Recipients Terminated NCT01817699 Phase 4
28 Corticosteroids Therapy and Pneumocystis Jirovecii Pneumonia (PCP) Withdrawn NCT00636935 Phase 4 Antibiotics only;Antibiotics + Corticosteroids;Corticosteroids + antibiotics
29 Pulmicort Respules on Relapse Rates After Treatment in the ED Withdrawn NCT00584636 Phase 4 pulmicort respules
30 Study of Trimethoprim/Sulfamethoxazole as PCP Prophylaxis in CTD Patients Unknown status NCT01747278 Phase 2, Phase 3 Trimethoprim/Sulfamethoxazole
31 Efficacy of Phytolacca Decandra and Melissa Officinalis in Children With Nocturnal Bruxism Unknown status NCT02870543 Phase 3 Phytolacca decandra;Melissa officinalis;Phyt.decandra + Melissa offic.
32 A Study of Pentamidine Plus Dapsone in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Patients Who Cannot Take Trimethoprim or Sulfonamides Completed NCT00001028 Phase 3 Pentamidine isethionate;Dapsone
33 A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides Completed NCT00000802 Phase 3 Atovaquone;Dapsone
34 A Randomized, Comparative, Prospective Study of Daily Trimethoprim / Sulfamethoxazole (TMS) and Thrice-Weekly TMS for Prophylaxis Against PCP in HIV-Infected Patients Completed NCT00000748 Phase 3 Sulfamethoxazole-Trimethoprim
35 A Study of Trimetrexate With Leucovorin Rescue for AIDS Patients Who Are Refractory to Standard Therapies for Pneumocystis Carinii Pneumonia Completed NCT00000724 Phase 3 Trimetrexate glucuronate;Leucovorin calcium
36 A Treatment Protocol for the Use of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia and Serious Intolerance to Approved Therapies Completed NCT00001016 Phase 3 Trimetrexate glucuronate;Leucovorin calcium
37 Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Completed NCT00001014 Phase 3 Trimetrexate glucuronate;Sulfamethoxazole-Trimethoprim;Leucovorin calcium
38 A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia in AIDS Completed NCT00000715 Phase 3 Pentamidine isethionate;Sulfamethoxazole-Trimethoprim
39 A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT) Completed NCT00000727 Phase 3 Pentamidine isethionate;Pyrimethamine;Sulfamethoxazole/Trimethoprim;Sulfadoxine/Pyrimethamine;Zidovudine
40 An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies Completed NCT00000714 Phase 3 Trimetrexate glucuronate;Leucovorin calcium
41 A Comparison of Atovaquone and Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia in HIV-Infected Patients Who Cannot Take TMP/SMX Completed NCT00002340 Phase 3 Atovaquone;Pentamidine isethionate
42 Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Completed NCT00001013 Phase 3 Trimetrexate glucuronate;Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Leucovorin calcium
43 A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS Completed NCT00000640 Phase 3 Primaquine;Sulfamethoxazole-Trimethoprim;Dapsone;Clindamycin
44 Virtual Continuity and Its Impact on Complex Hospitalized Patients' Care Completed NCT01397253 Phase 3
45 A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients Completed NCT00000991 Phase 3 Pentamidine isethionate;Sulfamethoxazole-Trimethoprim;Dapsone;Zidovudine
46 A Randomized, Unblinded Trial of Zidovudine Versus ddC in the Treatment of Patients Status Post PCP Who Received Long-Term Zidovudine Therapy in Protocol ACTG 002 Completed NCT00000682 Phase 3 Zidovudine;Zalcitabine
47 A Multi-Center Clinical Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS Post First Episode PCP Completed NCT00000700 Phase 3 Zidovudine
48 The Congestive Heart Failure Adherence Redesign Trial Completed NCT01698242 Phase 3
49 Using Social Incentives and Gamification for Weight Loss Promotion Completed NCT02564445 Phase 3
50 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole

Search NIH Clinical Center for Pneumocystosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: pneumonia, pneumocystis

Genetic Tests for Pneumocystosis

Anatomical Context for Pneumocystosis

MalaCards organs/tissues related to Pneumocystosis:

42
Lung, Kidney, Testes, Bone, Skin, Heart, Liver

Publications for Pneumocystosis

Articles related to Pneumocystosis:

(show top 50) (show all 1834)
# Title Authors Year
1
Incidence of pneumocystosis among patients exposed to immunosuppression. ( 30639289 )
2019
2
Genetic polymorphisms associated with treatment failure and mortality in pediatric Pneumocystosis. ( 30718779 )
2019
3
Pneumocystosis and quantitative PCR. ( 29789160 )
2018
4
Pneumocystosis in dogs: meta-analysis of 43 published cases including clinical signs, diagnostic procedures, and treatment. ( 29145787 )
2018
5
CT findings in Pneumocystis carinii pneumonia in five dogs. ( 29577303 )
2018
6
The changing trends and profile of pneumocystosis mortality in the United States, 1999-2014. ( 28568970 )
2017
7
Multiple myeloma presenting with bilateral ankle pain (microangiopathy) and complicated by streptococcal meningitis and Pneumocystis carinii pneumonia. ( 28174184 )
2017
8
Pneumocystosis revealing immunodeficiency secondary to<i>TERC</i>mutation. ( 29167304 )
2017
9
Grouped Cases of Pulmonary Pneumocystosis After Solid Organ Transplantation: Advantages of Coordination by an Infectious Diseases Unit for Overall Management and Epidemiological Monitoring. ( 27890037 )
2017
10
The lung microbiome in patients with pneumocystosis. ( 29202739 )
2017
11
Risk factors for mortality from pneumocystis carinii pneumonia (PCP) in non-HIV patients: a meta-analysis. ( 28938676 )
2017
12
Serological diagnosis of pneumocystosis: production of a synthetic recombinant antigen for immunodetection of Pneumocystis jirovecii. ( 27824115 )
2016
13
Increased dosage of infliximab is a potential cause of Pneumocystis carinii pneumonia. ( 26839596 )
2016
14
Common variable immune deficiency in a Pomeranian with Pneumocystis carinii pneumonia. ( 25715954 )
2015
15
Pneumocystis and Pneumocystosis: first meeting of experts from Latin-American and Portuguese-speaking countries - a mini-review. ( 24617414 )
2014
16
Adjunctive glucocorticoid therapy for non-HIV-related pneumocystis carinii pneumonia (NH-PCP). ( 24666835 )
2014
17
Histopathology of Pneumocystis carinii pneumonia in immunocompetent laboratory rats. ( 25009598 )
2014
18
Efficacy of caspofungin, a 1,3-β-D-glucan synthase inhibitor, on Pneumocystis carinii pneumonia in rats. ( 25288652 )
2014
19
Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review. ( 24275372 )
2013
20
Clinical outcomes of Pneumocystis carinii pneumonia in adult liver transplant recipients. ( 24157035 )
2013
21
Pneumocystosis in a patient with Crohn's disease treated with combination therapy with adalimumab. ( 22398055 )
2012
22
Pneumocystis carinii pneumonia in gastric cancer patients without acquired immune deficiency syndrome: 3 cases report and literature review. ( 22792534 )
2012
23
Chitinases in Pneumocystis carinii pneumonia. ( 22535444 )
2012
24
Dynamics of Pneumocystis carinii air shedding during experimental pneumocystosis. ( 21372312 )
2011
25
Pneumocystosis: a network survey in the Paris area 2003-2008. ( 21229281 )
2011
26
Epidemiological characteristics of pulmonary pneumocystosis and concurrent infections in pigs in Jeju Island, Korea. ( 21368558 )
2011
27
Pneumocystis carinii pneumonia prophylaxis: current therapies and recommendations. ( 21636828 )
2011
28
Development of Pneumocystis carinii pneumonia in patients with immunobullous and connective tissue disease receiving immunosuppressive medications. ( 19828210 )
2010
29
Risk of pneumocystosis after early discontinuation of prophylaxis among HIV-infected patients receiving highly active antiretroviral therapy. ( 20492660 )
2010
30
Pneumocystis carinii pneumonia in a HIV-positive patient. ( 20726370 )
2010
31
Late-onset and atypical presentation of Pneumocystis carinii pneumonia in a renal transplant recipient. ( 18758701 )
2009
32
Screening Pneumocystis carinii pneumonia in non-HIV-infected immunocompromised patients using polymerase chain reaction. ( 19631093 )
2009
33
Predictors of pneumocystosis or tuberculosis in HIV-infected Asian patients with AFB smear-negative sputum pneumonia. ( 18645508 )
2008
34
Activity of propolis in an experimental model of pneumocystosis. ( 18690302 )
2008
35
Splenic pneumocystosis: an atypical presentation of extrapulmonary Pneumocystis infection. ( 18975440 )
2008
36
Central retinal vein occlusion in an AIDS patient with presumed Pneumocystis carinii pneumonia. ( 18443615 )
2008
37
Otic pneumocystosis in acquired immune deficiency syndrome. ( 18496145 )
2008
38
S-adenosylmethionine levels in the diagnosis of Pneumocystis carinii pneumonia in patients with HIV infection. ( 18177224 )
2008
39
[Pneumocystis carinii pneumonia in a patient with hyper-IgE syndrome]. ( 17554982 )
2007
40
Cystic pneumocystosis in a patient with AIDS. ( 17992424 )
2007
41
Pneumocystis carinii pneumonia in infant treated with oral steroids for hemangioma. ( 17875903 )
2007
42
Pneumocystis carinii pneumonia in a patient on etanercept for psoriatic arthritis. ( 17906888 )
2007
43
Pneumocystis carinii pneumonia in an infant with hypogammaglobulinemia. ( 17165040 )
2007
44
Prophylaxis of Pneumocystis carinii pneumonia with atovaquone in children with leukemia. ( 17345613 )
2007
45
A background and critical analysis of the treatment of pneumocystis carinii pneumonia (PCP) in HIV/AIDS. ( 17441498 )
2007
46
Pneumocystis carinii pneumonia in a rheumatoid arthritis patient treated with adalimumab. ( 17464877 )
2007
47
Pneumocystis carinii pneumonia in immunocompromised host--an autopsy report of three cases. ( 17474255 )
2007
48
Usefulness of beta-D glucan in diagnosing Pneumocystis carinii pneumonia and monitoring its treatment in a living-donor liver-transplant recipient. ( 17520208 )
2007
49
Patients receiving standard-dose temozolomide therapy are at risk of Pneumocystis carinii pneumonia. ( 17644327 )
2007
50
The 'dark bronchus' sign: HRCT diagnosis of Pneumocystis carinii pneumonia. ( 19724672 )
2007

Variations for Pneumocystosis

Expression for Pneumocystosis

Search GEO for disease gene expression data for Pneumocystosis.

Pathways for Pneumocystosis

Pathways related to Pneumocystosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 CD4 CD40LG TNF TNFRSF1B
2
Show member pathways
12.23 CD4 CD40LG TNF TNFRSF1B
3 11.9 CD40LG TNF TNFRSF1B
4
Show member pathways
11.83 MUC1 SFTPD TNF
5 11.56 CD4 GYPA TNF
6 11.49 MUC1 TNF TNFRSF1B
7 11.32 CD4 GYPA TNF
8 11.04 CD40LG TNFRSF1B
9 11.02 TNF TNFRSF1B
10
Show member pathways
11 CD40LG TNF TNFRSF1B
11 10.99 DHFR TNF
12 10.94 CD4 TNF
13 10.49 CD40LG GYPA TNF

GO Terms for Pneumocystosis

Biological processes related to Pneumocystosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 CD4 CD40LG TNF TNFRSF1B
2 inflammatory response GO:0006954 9.62 CD40LG CLEC7A TNF TNFRSF1B
3 cytokine-mediated signaling pathway GO:0019221 9.46 CD4 MUC1 TNF TNFRSF1B
4 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.26 TNF TNFRSF1B
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.13 CD40LG TNF TNFRSF1B
6 regulation of immunoglobulin secretion GO:0051023 8.62 CD40LG TNF

Molecular functions related to Pneumocystosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.73 ALB CD4 CD40LG CLEC7A DHFR DHPS
2 tumor necrosis factor receptor binding GO:0005164 9.16 CD40LG TNF
3 identical protein binding GO:0042802 9.1 ALB CD4 DHPS GYPA SFTPD TNF

Sources for Pneumocystosis

3 CDC
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