Pneumonia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PNM007 MIFTS: 69	Pneumonia Categories: Respiratory diseases, Infectious diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Download Expand all tables

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Aliases & Classifications for Pneumonia

MalaCards integrated aliases for Pneumonia:

Name: Pneumonia ¹² ⁷⁶ ²⁹ ⁵⁵ ⁶ ⁴³ ³ ³ ⁴⁴ ¹⁵ ⁶³ ⁷³

Acute Pneumonia ¹² ⁷³

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:552

MeSH ⁴⁴ D011014

NCIt ⁵⁰ C3333

SNOMED-CT ⁶⁸ 155548002 155552002 155558003 more

UMLS ⁷³ C0032285 C0740766

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Summaries for Pneumonia

MedlinePlus : ⁴³ Pneumonia is an infection in one or both of the lungs. Many germs, such as bacteria, viruses, and fungi, can cause pneumonia. You can also get pneumonia by inhaling a liquid or chemical. People most at risk are older than 65 or younger than 2 years of age, or already have health problems. Symptoms of pneumonia vary from mild to severe. See your doctor promptly if you Have a high fever Have shaking chills Have a cough with phlegm that doesn't improve or gets worse Develop shortness of breath with normal daily activities Have chest pain when you breathe or cough Feel suddenly worse after a cold or the flu Your doctor will use your medical history, a physical exam, and lab tests to diagnose pneumonia. Treatment depends on what kind you have. If bacteria are the cause, antibiotics should help. If you have viral pneumonia, your doctor may prescribe an antiviral medicine to treat it. Preventing pneumonia is always better than treating it. Vaccines are available to prevent pneumococcal pneumonia and the flu. Other preventive measures include washing your hands frequently and not smoking. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Pneumonia, also known as acute pneumonia, is related to bronchopneumonia and idiopathic interstitial pneumonia, and has symptoms including coughing, fever and hemoptysis. An important gene associated with Pneumonia is LINC02258 (Long Intergenic Non-Protein Coding RNA 2258
These novel lncRNAs and their target genes may be closely associated with the progression of pneumonia.
Dysfunction Pattern: ), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Augmentin and Avelox I.V. have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related phenotypes are hematopoietic system and immune system

Disease Ontology : ¹² A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing.

CDC : ³ Pneumocystis jirovecii in the lung of an HIV/AIDS patient.

PubMed Health : ⁶³ About pneumonia: Pneumonia (nu-MO-ne-ah) is an infection in one or both of the lungs. Many germs—such as bacteria, viruses, and fungi—can cause pneumonia.The infection inflames your lungs' air sacs, which are called alveoli (al-VEE-uhl-eye). The air sacs may fill up with fluid or pus, causing symptoms such as a cough with phlegm (a slimy substance), fever, chills, and trouble breathing.

Wikipedia : ⁷⁶ Pneumonia is an inflammatory condition of the lung affecting primarily the small air sacs known as... more...

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Related Diseases for Pneumonia

Diseases in the Pneumonia family:

Viral Pneumonia

Diseases related to Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1094)

#	Related Disease	Score	Top Affiliating Genes
1	bronchopneumonia	34.0	CD40LG ELANE MPO
2	idiopathic interstitial pneumonia	34.0	CCL2 CXCL8 ELANE MUC5B SFTPC SFTPD
3	pneumocystosis	33.9	CD40LG SFTPD TNF
4	avian influenza	33.2	CXCL8 IL6 SFTPD TNF
5	q fever	33.0	CD40LG IL10 IL1B TLR2 TNF
6	invasive aspergillosis	32.9	CXCL8 SFTPD TLR2
7	bronchiolitis obliterans	32.8	CXCL8 IL10 IL6 MPO TNF
8	legionellosis	32.8	CD40LG TLR2 TLR5 TNF
9	pulmonary fibrosis, idiopathic	32.8	CCL2 CXCL8 ELANE IL1B MUC5B SFTPC
10	common variable immunodeficiency	32.8	CD40LG IL10 IL6 TNF
11	pulmonary hemosiderosis	32.7	CD40LG MPO MUC5B
12	adult respiratory distress syndrome	32.4	CXCL8 ELANE IL10 IL6 SFTPC TNF
13	melioidosis	32.2	IL10 IL6 TLR2 TLR5 TNF TREM1
14	respiratory failure	32.2	CRP CXCL8 ELANE SFTPC SFTPD TNF
15	bronchiolitis	32.2	CCL11 CD40LG CXCL8 IL10 IL6 MUC5B
16	toxic shock syndrome	31.9	CXCL8 IL10 IL1B IL6 TLR2 TNF
17	acute respiratory distress syndrome	31.9	CXCL8 ELANE IL1B IL6 SFTPC SFTPD
18	haemophilus influenzae	31.5	CXCL8 IL1B TLR2 TNF
19	hematopoietic stem cell transplantation	31.5	IL10 IL6 TNF
20	fasciitis	31.4	CXCL8 IL6 TNF
21	extrinsic allergic alveolitis	31.4	CCL2 CXCL8 IL10 IL1B IL6 MPO
22	transverse myelitis	31.3	CXCL8 IL10 IL6 TNF
23	interstitial lung disease	31.3	CCL2 CXCL8 IL10 IL1B IL6 MUC5B
24	aspergillosis	31.2	ELANE IL10 SFTPD TLR2
25	connective tissue disease	31.2	CD40LG IL10 IL6 SFTPD TNF
26	purpura	31.2	CD40LG CRP TNF
27	pericarditis	31.2	CRP IL1B IL6 TNF
28	laryngitis	31.2	IL1B IL6 TNF
29	chlamydia	31.2	CD40LG CRP CXCL8 IL10 IL1B IL6
30	pharyngitis	31.2	CRP CXCL8 IL1B
31	bacteriuria	31.2	CD40LG CXCL8 IL6
32	spondylitis	31.1	CD40LG CRP IL6 TNF
33	cytomegalovirus infection	31.1	CXCL8 IL10 IL6 TNF
34	anterior uveitis	31.1	CCL2 IL6 TLR2
35	mycobacterium abscessus	31.1	CXCL8 TLR2 TNF
36	arthritis	31.1	CCL2 CXCL8 IL10 IL1B IL6 TNF
37	viral infectious disease	31.1	CD40LG CXCL8 IL10 IL1B IL6 TNF
38	spondyloarthropathy 1	31.1	CD40LG CRP TNF
39	myelitis	31.1	CCL11 IL6 TNF
40	pulmonary fibrosis	31.0	CCL2 IL1B MUC5B SFTPC SFTPD
41	temporal arteritis	31.0	CCL2 CD40LG CRP IL6
42	acute transverse myelitis	31.0	CXCL8 IL10 IL6
43	ischemic heart disease	31.0	CRP IL6 TNF
44	myocarditis	31.0	CD40LG IL6 TNF
45	osteomyelitis	31.0	CXCL8 IL1B IL6 TNF
46	acquired immunodeficiency syndrome	31.0	CD40LG IL10 IL1B IL6 TNF
47	reactive arthritis	30.9	CRP IL10 IL6 TNF
48	bronchitis	30.9	CCL11 CD40LG CXCL8 ELANE MPO TNF
49	mixed connective tissue disease	30.9	CD40LG IL10 IL6 TNF
50	cold agglutinin disease	30.9	CRP IL6

Graphical network of the top 20 diseases related to Pneumonia:

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Symptoms & Phenotypes for Pneumonia

UMLS symptoms related to Pneumonia:

coughing, fever, hemoptysis, pruritus, snoring

MGI Mouse Phenotypes related to Pneumonia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.17	IL6 CCL11 CD40LG MPO MUC5B CSF3
2	immune system	MP:0005387	10.09	CCL2 CD40LG MPO CRP MUC5B CSF3
3	cardiovascular system	MP:0005385	10.07	IL6 CD40LG MPO CRP SFTPC IL10
4	homeostasis/metabolism	MP:0005376	10.07	IL6 CD40LG MPO CRP MUC5B ELANE
5	neoplasm	MP:0002006	9.56	IL6 ELANE SFTPC IL10 TLR2 IL1B
6	respiratory system	MP:0005388	9.28	IL6 CCL11 MUC5B SFTPC IL10 SFTPD

Sources

Drugs & Therapeutics for Pneumonia

PubMedHealth treatment related to Pneumonia: ⁶³

Treatment for pneumonia depends on the type of pneumonia you have and how severe it is. Most people who have community-acquired pneumonia—the most common type of pneumonia—are treated at home.The goals of treatment are to cure the infection and prevent complications.

FDA approved drugs:

(show all 7)

#	Drug Name	Active Ingredient(s) ¹⁸	Company	Approval Date
1	Augmentin ¹⁸	AMOXICILLIN; CLAVULANATE POTASSIUM	SmithKline Beecham	February 1996
FDA Label: Augmentin Disease/s that Drug Treats:sinusitis, bronchitis, pneumonia Indications and Usage: ¹⁸ AUGMENTIN is a combination penicillin-class antibacterial and beta-lactamase inhibitor indicated for treatment of the following: Lower respiratory tract infections (1.1) Acute bacterial otitis media (1.2) Sinusitis (1.3) Skin and skin structure infections (1.4) Urinary tract infections (1.5) DrugBank Targets: ¹⁶ ¹⁶ Beta-lactamase\|Penicillin-binding protein 1A Mechanism of Action: ¹⁸ Target: - Action: - FDA: AUGMENTIN is an antibacterial drug. [see Microbiology 12.4]. Amoxicillin is a semisynthetic antibiotic with in vitro bactericidal activity against Grampositive and Gram-negative bacteria. Amoxicillin is, however, susceptible to degradation by beta-lactamases, and therefore, the spectrum of activity does not include organisms which produce these enzymes. Clavulanic acid is a beta-lactam, structurally related to the penicillins, which possesses the ability to inactivate some beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. In particular, it has good activity against the clinically important plasmid-mediated beta-lactamases frequently responsible for transferred drug resistance. The formulation of amoxicillin and clavulanic acid in AUGMENTIN protects amoxicillin from degradation by some beta-lactamase enzymes and extends the antibiotic spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin. Amoxicillin/clavulanic acid has been shown to be active against most isolates of the following bacteria, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section.
2	Avelox I.V. ¹⁸	MOXIFLOXACIN HYDROCHLORIDE	Bayer	November 2001
FDA Label: Avelox I.V. Disease/s that Drug Treats:Susceptible strains of sinusitis, bronchitis, pneumonia, skin structure infections Indications and Usage: ¹⁸ AVELOX is a fluoroquinolone antibacterial indicated for treating infections in adults 18 years of age and older caused by designated susceptible bacteria, in the conditions listed below: * Acute Bacterial Sinusitis (1.1) * Acute Bacterial Exacerbation of Chronic Bronchitis (1.2) * Community Acquired Pneumonia (1.3) * Skin and Skin Structure Infections: Uncomplicated (1.4) and Complicated (1.5) * Complicated Intra-Abdominal Infections (1.6) * Plague (1.7) To reduce the development of drug-resistant bacteria and maintain the effectiveness of AVELOX and other antibacterial drugs. AVELOX should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. (1.8) DrugBank Targets: ¹⁶ DNA gyrase subunit A\|DNA topoisomerase 4 subunit A\|DNA topoisomerase 2-alpha Mechanism of Action: ¹⁸ Target: topoisomerase II (DNA gyrase) and topoisomerase IV Action: inhibitpr FDA: AVELOX is a member of the fluoroquinolone class of antibacterial agents [see Microbiology (12.4)]. The bactericidal action of moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV required for bacterial DNA replication, transcription, repair, and recombination.
3	Teflaro ¹⁸	CEFTAROLINE FOSAMIL	Cerexa	Nov-10
FDA Label: Teflaro Disease/s that Drug Treats:bacterial skin infections and bacterial pneumonia Indications and Usage: ¹⁸ TeflaroÂ® is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: * Acute bacterial skin and skin structure infections (ABSSSI) (1.1) * Community-acquired bacterial pneumonia (CABP) (1.2) To reduce the development of drug-resistant bacteria and maintain the effectiveness of Teflaro and other antibacterial drugs, Teflaro should be used only to treat infections that are proven or strongly suspected to be caused by bacteria (1.3). DrugBank Targets: - Mechanism of Action: ¹⁸ Target: essential penicillin-binding proteins (PBPs) Action: - FDA: Ceftaroline is a cephalosporin antibacterial [see Microbiology (12.4)]. Ceftaroline is a cephalosporin with in vitro activity against Gram-positive and -negative bacteria. The bactericidal action of ceftaroline is mediated through binding to essential penicillin-binding proteins (PBPs). Ceftaroline is bactericidal against S. aureus due to its affinity for PBP2a and against Streptococcus pneumoniae due to its affinity for PBP2x.
4	Tequin ¹⁸		Bristol-Myers Squibb	December, 1999
FDA Label: Tequin Disease/s that Drug Treats:Community-acquired respiratory tract infections Indications and Usage: ¹⁸ DrugBank Targets: ¹⁶ DNA gyrase subunit A\|DNA gyrase subunit B\|DNA topoisomerase 4 subunit A\|DNA topoisomerase 4 subunit B Mechanism of Action: ¹⁸ Target: DNA gyrase Action: inhibitor FDA: -
5	Tygacil ¹⁸	TIGECYCLINE	Wyeth	2005
FDA Label: Tygacil Disease/s that Drug Treats:complicated skin and skin structure and intra-abdominal infections and bacterial pneumonia Indications and Usage: ¹⁸ TYGACIL is a tetracycline class antibacterial indicated in patients 18 years of age and older for: * Complicated skin and skin structure infections (1.1) * Complicated intra-abdominal infections (1.2) * Community-acquired bacterial pneumonia (1.3) Limitations of Use: TYGACIL is not indicated for treatment of diabetic foot infection or hospital-acquired pneumonia, including ventilatorassociated pneumonia (1.4). To reduce the development of drug-resistant bacteria and maintain the effectiveness of TYGACIL and other antibacterial drugs, TYGACIL should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. DrugBank Targets: ¹⁶ 16S rRNA\|30S ribosomal protein S9\|30S ribosomal protein S12\|30S ribosomal protein S13\|30S ribosomal protein S14\|30S ribosomal protein S19 Mechanism of Action: ¹⁸ Target: 30S ribosomal subunit Action: inhibits protein translation FDA: Tigecycline is a tetracycline class antibacterial [see Microbiology (12.4)]. Tigecycline inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules into the A site of the ribosome. This prevents incorporation of amino acid residues into elongating peptide chains. In general, tigecycline is considered bacteriostatic; however, TYGACIL has demonstrated bactericidal activity against isolates of S. pneumoniae and L. pneumophila.
6	Vibativ ¹⁸	* TELAVANCIN * TELAVANCIN HYDROCHLORIDE	Theravance	June 2013
FDA Label: Vibativ Disease/s that Drug Treats:hospital-acquired and ventilator-associated bacterial pneumonia caused by staph aureus Indications and Usage: ¹⁸ VIBATIV is a lipoglycopeptide antibacterial drug indicated for the treatment of the following infections in adult patients caused by designated susceptible bacteria: * Complicated skin and skin structure infections (cSSSI) (1.1) * Hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) caused by susceptible isolates of Staphylococcus aureus. VIBATIV should be reserved for use when alternative treatments are not suitable. (1.2) DrugBank Targets: - Mechanism of Action: ¹⁸ Target: late-stage peptidoglycan precursors Action: inhibits cell wall biosynthesis FDA: Telavancin is an antibacterial drug [see Clinical Pharmacology (12.4)]. Telavancin inhibits cell wall biosynthesis by binding to late-stage peptidoglycan precursors, including lipid II. Telavancin also binds to the bacterial membrane and disrupts membrane barrier function.
7	Zosyn ¹⁸	PIPERACILLIN SODIUM; TAZOBACTAM SODIUM	Wyeth	May 1996
FDA Label: Zosyn Disease/s that Drug Treats:pneumonia Indications and Usage: ¹⁸ ZOSYN is a combination penicillin-class antibacterial and Î²-lactamase inhibitor indicated for treatment of: * Intra-abdominal infections (1.1) * Skin and skin structure infections (1.2) * Female pelvic infections (1.3) * Community-acquired pneumonia (1.4) * Nosocomial pneumonia (1.5) DrugBank Targets: ¹⁶ ¹⁶ Beta-lactamase SHV-1\|Beta-lactamase TEM\|Penicillin-binding protein 3\|Penicillin-binding protein 2B\|Penicillin-binding protein 2a\|Penicillin-binding protein 1b Mechanism of Action: ¹⁸ Target: - Action: - FDA: ZOSYN is an antibacterial drug [see Microbiology (12.4)].Mechanism of Action Piperacillin sodium exerts bactericidal activity by inhibiting septum formation and cell wall synthesis of susceptible bacteria. In vitro, piperacillin is active against a variety of Gram-positive and Gram-negative aerobic and anaerobic bacteria. Tazobactam sodium has little clinically relevant in vitro activity against bacteria due to its reduced affinity to penicillin-binding proteins. It is, however, a Î²-lactamase inhibitor of the Molecular class A enzymes, including RichmondSykes class III (Bush class 2b & 2b') penicillinases and cephalosporinases. It varies in its ability to inhibit class II and IV (2a & 4) penicillinases. Tazobactam does not induce chromosomallymediated Î²-lactamases at tazobactam concentrations achieved with the recommended dosage regimen.

Drugs for Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1016)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Zinc

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

7440-66-6

23994

Lidocaine

Approved, Vet_approved

Phase 4,Phase 2,Not Applicable

137-58-6

3676

Tazobactam

Approved

Phase 4,Phase 2,Phase 3,Phase 1

89786-04-9

123630

Cilastatin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

82009-34-5

5280454 6435415

Ceftriaxone

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

73384-59-5

5479530 5361919

Sulfamethoxazole

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

723-46-6

5329

Amikacin

Approved, Investigational, Vet_approved

Phase 4,Phase 2,Phase 3,Not Applicable

37517-28-5

37768

Menthol

Approved

Phase 4,Phase 2,Phase 1,Not Applicable

2216-51-5

16666

Enfuvirtide

Approved, Investigational

Phase 4,Phase 2,Not Applicable

159519-65-0

16130199

Tetracycline

Approved, Vet_approved

Phase 4,Phase 1,Early Phase 1

60-54-8

5353990

Nicotine

Approved

Phase 4,Not Applicable

54-11-5

942 89594

Simvastatin

Approved

Phase 4,Phase 3,Phase 1,Phase 2

79902-63-9

54454

Hydrocortisone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

50-23-7

5754

Ciprofloxacin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

85721-33-1

2764

Sevoflurane

Approved, Vet_approved

Phase 4,Phase 1,Phase 2

28523-86-6

5206

Meropenem

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

119478-56-7

64778 441130

Erythromycin

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

114-07-8

12560

Bupivacaine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2180-92-9, 38396-39-3

2474

Doxycycline

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1

564-25-0

54671203

Iron

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

7439-89-6

23925

Telithromycin

Approved

Phase 4,Phase 3,Phase 2

191114-48-4

5462516 0

Ganciclovir

Approved, Investigational

Phase 4,Phase 1,Phase 2,Not Applicable

82410-32-0

3454

Azithromycin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

83905-01-5

55185 447043

Clarithromycin

Approved

Phase 4,Phase 3,Phase 2

81103-11-9

84029

Omeprazole

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

73590-58-6

4594

Minocycline

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2

10118-90-8

5281021

Penicillin G

Approved, Vet_approved

Phase 4,Phase 3

61-33-6

5904

Moxifloxacin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

354812-41-2, 151096-09-2

152946

Budesonide

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

51333-22-3

63006 5281004

Trimethoprim

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

738-70-5

5578

Cefepime

Approved, Investigational

Phase 4,Phase 3,Not Applicable

88040-23-7

5479537

Cefoxitin

Approved

Phase 4,Phase 2

35607-66-0

441199

Atracurium

Approved, Experimental, Investigational

Phase 4

64228-79-1

47319

Tramadol

Approved, Investigational

Phase 4,Not Applicable

27203-92-5

33741

Ofloxacin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

82419-36-1

4583

Linezolid

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

165800-03-3

441401

Estradiol valerate

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

979-32-8

Bosentan

Approved, Investigational

Phase 4,Phase 3,Phase 2

147536-97-8

104865

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

22916-47-8

4189

Oseltamivir

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

204255-11-8, 196618-13-0

65028

Atropine

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

5908-99-6, 51-55-8

174174

Rocuronium

Approved

Phase 4,Not Applicable

119302-91-9, 143558-00-3

441290

Tranexamic Acid

Approved

Phase 4,Phase 3,Not Applicable

1197-18-8

5526

Pirfenidone

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

53179-13-8

40632

Cyclophosphamide

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

50-18-0, 6055-19-2

2907

Imipenem

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

74431-23-5, 64221-86-9

104838

Metronidazole

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

443-48-1

4173

Colistin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

1264-72-8, 1066-17-7

5311054

Calcium Carbonate

Approved, Investigational

Phase 4

471-34-1

Etanercept

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2

185243-69-0

Interventional clinical trials:

(show top 50) (show all 3293)

#	Name	Status	NCT ID	Phase	Drugs
1	Ventilator Associated Pneumonia in Taper Guard Versus Normal Tube in ICU Patients	Unknown status	NCT01501227	Phase 4
2	Clinical Pathway Based on Procalcitonin Levels for the Management of Community-acquired Pneumonia in Outpatients	Unknown status	NCT02600806	Phase 4	Azithromycin;Levofloxacin
3	Pharmacokinetic and Pharmacodynamic Evaluation of Linezolid Administered Intravenously in MRSA-positive, Morbidly Obese Patients With Pneumonia	Unknown status	NCT01805284	Phase 4	Linezolid
4	Corticosteroid Therapy for Severe Community-Acquired Pneumonia	Unknown status	NCT02552342	Phase 4	methylprednisolone;Normal saline
5	Probiotics for Prevention of Ventilator-Associated Pneumonia (VAP)	Unknown status	NCT01301131	Phase 4
6	Duration of Antibiotic Therapy in Community - Acquired Pneumonia	Unknown status	NCT01492387	Phase 4
7	Ventilator-associated Pneumonia (VAP) and Humidification System	Unknown status	NCT01546974	Phase 4
8	Linezolid Alone or Combined With Carbapenem Against Methicillin-resistant Staphylococcus Aureus (MRSA) in Ventilator-associated Pneumonia	Unknown status	NCT01356472	Phase 4	Imipenem/cilastatin
9	Efficacy and Safety Trial to Assess Moxifloxacin in Treating Community-Acquired Pneumonia (CAP) With Aspiration Factors	Unknown status	NCT00752947	Phase 4	moxifloxacin;levofloxacin;metronidazole
10	Chlorhexidine Gluconate for Prevention of Ventilator Associated Pneumonia in Children.	Unknown status	NCT01883596	Phase 4	0.12% chlorhexidine solution;Placebo
11	Chinese Medicinal Herbs Treatment on Novel Influenza A (H1N1)Pneumonia: Multi-centre, Prospective, Randomized Controlled Study	Unknown status	NCT00936013	Phase 4	oseltamivir;oseltamivir and chinese medicinal herbs
12	SDD for Eradicating CRKP Carriage	Unknown status	NCT01761487	Phase 4
13	Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome	Unknown status	NCT02370550	Phase 4	Cyclosporin A;Prednisone;Placebo;Calcium carbonate D
14	PTH - Preemptive Treatment for Herpesviridae	Unknown status	NCT02152358	Phase 4	Aciclovir;Ganciclovir;Placebo
15	7-valent Pneumococcal Conjugated Vaccination	Unknown status	NCT00885625	Phase 4
16	Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections	Unknown status	NCT02171338	Phase 4
17	Lactobacillus Preparation on the Incidence of Diarrhea	Unknown status	NCT01792739	Phase 4	Lactobacillus casei variety rhamnosus granules;Placebo
18	Effect of Vitamin D Supplementation in Young South African Children Hospitalized With Acute Lower Respiratory Infection	Unknown status	NCT02054182	Phase 4	Vitamin D
19	Pneumonia Vaccine in Liver Transplant Recipients: a Booster Strategy Using a Conjugate Vaccine	Unknown status	NCT00152802	Phase 4
20	Optimizing Influenza Vaccination in Surgical Oncology Patients	Unknown status	NCT01698177	Phase 4
21	Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda	Unknown status	NCT00674921	Phase 4	cotrimoxazole;Placebo
22	Safety and Efficacy Study of High Dose Colistin	Unknown status	NCT02162966	Phase 4	High Dose Colistin;Standard Dose Colistin
23	Bosentan in Pulmonary Hypertension in Interstitial Lung Disease Treatment Study	Unknown status	NCT00637065	Phase 4	Bosentan;Placebo
24	Middle Meatal Bacteriology During Acute Respiratory Infection in Children	Unknown status	NCT00545961	Phase 4	placebo;amoxicillin clavulanate acid
25	Comparing Treatment Efficacy With HD/MD Flu Plus Sal in Chronic Obstructive Pulmonary Disease (COPD) Patients	Unknown status	NCT01131806	Phase 4	fluticasone/ salmeterol 125/25 mcg/puff;fluticasone/ salmeterol 250/25 mcg/puff
26	LGG for Prevention of Infectious Complications During PPI Treatment in Children	Unknown status	NCT01782118	Phase 4
27	Empirical vs 2nd Line Antibiotic Therapy in Health-care Associated Infections in Cirrhosis	Unknown status	NCT01820026	Phase 4	Imipenem;Vancomycin;azithromycin;Cefotaxime;Amoxicillin
28	Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD)	Unknown status	NCT01822106	Phase 4
29	Prevention of Chronic Lung Disease (CLD) in Preterm Infants	Unknown status	NCT00883532	Phase 4	budesonide;surfactant and air (placebo)
30	Influence of Moderate Inspired Oxygen Fraction (FiO2) and Protective Ventilation on Postoperative Pulmonary Complication	Unknown status	NCT02198625	Phase 4
31	Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure.	Unknown status	NCT00331656	Phase 4
32	Efficacy of Nebulized Pulmicort Respules in Primary Lung Cancer Patients With COPD	Unknown status	NCT02504801	Phase 4	Budesonide
33	Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS)	Unknown status	NCT01573715	Phase 4	NIMBEX;NIMBEX
34	Comparing Treatment Efficacy With High and Medium Dose of Fluticasone in Combination With Salmeterol in COPD Patients	Unknown status	NCT01657487	Phase 4	Fluticasone/Salmeterol high dose
35	Effect of Enteral Genistein Supplementation in Sepsis	Unknown status	NCT02796794	Phase 4
36	Polysaccharide Antibody Response Study	Unknown status	NCT02429531	Phase 4
37	Influence of BCG on TDaP-IPV Vaccination	Unknown status	NCT02771782	Phase 4
38	Effect of Daily Nicotine Patch Application on Mechanical Ventilation Weaning in Smoking Patients	Unknown status	NCT01104896	Phase 4	Nicotine patch;Placebo
39	Diverticulitis: Antibiotics or Close Observation?	Unknown status	NCT01111253	Phase 4	Amoxicillin-clavulanate
40	Effect of Omega-3 Fatty Acids on the Perioperative Immune Response and Erythrocyte Function	Unknown status	NCT02231203	Phase 4	Omegaven;Placebo
41	A Study of Residual Curarization Incidence in China	Unknown status	NCT01690338	Phase 4	Vecuronium Bromide;Rocuronium;Cisatracurium
42	Acute Effect of Sildenafil on Exercise Tolerance and Functional Capacity in COPD, IPF and Post Pneumonectomy Patients	Unknown status	NCT01382368	Phase 4	Sildenafil
43	Comparisons of Inhaled LAMA or ICS+LABA for COPD With Bronchiectasis	Unknown status	NCT02546297	Phase 4	Symbicort;Tiotropium Bromide
44	Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner	Unknown status	NCT01555047	Phase 4
45	Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents	Unknown status	NCT02404779	Phase 4	cisatracurium besilate
46	Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced	Unknown status	NCT01661985	Phase 4	Azithromycin;Doxycycline;lymecycline
47	The Effect of Chest Tubes Using Active Clearance Technology® on the Incidence of Postoperative Atrial Fibrillation	Unknown status	NCT02808897	Phase 4
48	Targeting of Immune Response After Pneumococcal Vaccination	Completed	NCT01402245	Phase 4
49	Home Management of Malaria and Pneumonia	Completed	NCT02151578	Phase 4
50	Vitamin D Supplementation and Respiratory Index of Severity in Children (RISC) in Pneumonia	Completed	NCT02936895	Phase 4	Vitamin D3;Placebo

Search NIH Clinical Center for Pneumonia

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

acetylcysteine

oxygen

sucralfate

Cochrane evidence based reviews: pneumonia

Sources

Genetic Tests for Pneumonia

Genetic tests related to Pneumonia:

#	Genetic test	Affiliating Genes
1	Pneumonia ²⁹

Sources

Anatomical Context for Pneumonia

MalaCards organs/tissues related to Pneumonia:

⁴¹

Lung, Testes, Heart, Colon, Liver, Skin, Brain

Sources

Publications for Pneumonia

Articles related to Pneumonia:

(show top 50) (show all 6805)

#	Title	Authors	Year
1	Systematic dysphagia screening and dietary modifications to reduce stroke-associated pneumonia rates in a stroke-unit. ( 29389984 )	Teuschl Y....Brainin M.	2018
2	Effect of starting oral intake on weekends on the clinical course of patients with aspiration pneumonia. ( 29780243 )	Kenzaka T....Okayama M.	2018
3	Synthetic avenues towards a tetrasaccharide related to <i>Streptococcus pneumonia</i> of serotype 6A. ( 29977381 )	Chaudhury A....Ghosh R.	2018
4	Prevalence and impact of WHO group 3 pulmonary hypertension in advanced idiopathic nonspecific interstitial pneumonia. ( 29773690 )	King C.S....Nathan S.D.	2018
5	A Randomized Controlled Trial to Investigate the Effectiveness of the Prevention of Aspiration Pneumonia Using Recommendations for Swallowing Care Guided by Ultrasound Examination. ( 29439537 )	Miura Y....Sanada H.	2018
6	Chlamydia pneumoniae infection promotes monocyte transendothelial migration by increasing vascular endothelial cell permeability via the tyrosine phosphorylation of VE-cadherin. ( 29462613 )	Liu J....Zhang L.	2018
7	Purulent pericarditis, an unusual complication of pneumococcal pneumonia: a case report. ( 29322942 )	Zoulati G....Mahmoud M.	2018
8	Common variable immunodeficiency presenting in a man with recurrent pneumonia caused by <i>Staphylococcus lugdunensis</i>. ( 29559491 )	Mbaebie N.C....Touhey J.	2018
9	Bronchiolitis obliterans organizing pneumonia after stereotactic ablative radiation therapy for lung cancer: A case report. ( 29395853 )	Fanetti G....Jereczek-Fossa B.A.	2018
10	Combined pharmacotherapy for osteonecrosis of the femoral head after severe acute respiratory syndrome and interstitial pneumonia: two and a half to fourteenA year follow-up. ( 29594456 )	Wang W....Gao F.	2018
11	Association of serum high-mobility group box protein 1 level with outcomes of acute exacerbation of idiopathic pulmonary fibrosis and fibrosing nonspecific interstitial pneumonia. ( 29795561 )	Shimizu H....Homma S.	2018
12	Bronchiolitis obliterans organising pneumonia as an initial manifestation in a patient with systemic lupus erythematosus: a rare presentation. ( 29804073 )	Jatwani S....Chugh K.	2018
13	Legionella Pneumonia Complicated with Acquired Fanconi Syndrome: A Case Report. ( 29877286 )	Koda R....Narita I.	2018
14	Aspiration pneumonia induces muscle atrophy in the respiratory, skeletal, and swallowing systems. ( 29790300 )	Komatsu R....Ichinose M.	2018
15	Systemic scleroderma-related interstitial pneumonia associated with borderline pulmonary arterial hypertension. ( 29804068 )	Sugino K....Homma S.	2018
16	Mutant selection window of four quinolone antibiotics against clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. ( 29290527 )	Nakai H....Fujimura S.	2018
17	Reply to the letter: &quot;Pericardial effusion in community-acquired pneumonia: casuality or etiology?&quot; ( 29735269 )	Biteker F.S....A8elik O.	2018
18	Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: a case report. ( 29408183 )	Iijima Y....Miyashita Y.	2018
19	Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice. ( 29212906 )	Maltby S....Foster P.S.	2018
20	Using oral health assessment to predict aspiration pneumonia in older adults. ( 29446124 )	Noguchi S....Mukae H.	2018
21	Pulmonary Adenocarcinoma Mimicking Desquamative Interstitial Pneumonia: Report of 2 Cases With Genetic Analysis. ( 29720004 )	Miyaoka M....Nakamura N.	2018
22	Tigecycline application in a 3-month-old infant with multiple drug resistant <i>Klebsiella pneumonia</i>: a case report. ( 29977345 )	Peng C....Hou X.	2018
23	Pneumomediastinum and Pneumothorax Associated with Herpes Simplex Virus (HSV) Pneumonia. ( 29379004 )	LA^pez-Rivera F....Garcia Puebla J.	2018
24	Whole-genome sequence analysis of<i>Streptococcus pneumoniae</i>strains that cause hospital-acquired pneumonia infections. ( 29444837 )	Chang B....Ohnishi M.	2018
25	Severe pneumonia associated with ibrutinib monotherapy for CLL and lymphoma. ( 28156016 )	Kreiniz N....Tadmor T.	2018
26	Treating nosocomial pneumonia: what's new. ( 29978856 )	Frantzeskaki F....Orfanos S.E.	2018
27	A challenging case of carbapenemase-producing Klebsiella pneumoniae septic thrombophlebitis and right mural endocarditis successfully treated with ceftazidime/avibactam. ( 29926399 )	Iacovelli A....Venditti M.	2018
28	Comparison of Videofluoroscopic Swallowing Study and Radionuclide Salivagram for Aspiration Pneumonia in Children With Swallowing Difficulty. ( 29560324 )	Kim G.E....Kim J.S.	2018
29	A Serological Biomarker of Versican Degradation is Associated with Mortality Following Acute Exacerbations of Idiopathic Interstitial Pneumonia. ( 29728109 )	Sand J.M.B....Munakata M.	2018
30	Ceftazidime/Avibactam for Refractory Bacteremia, Vertebral Diskitis/Osteomyelitis with Pre-Vertebral Abscess and Bilateral Psoas Pyomyositis Secondary to Klebsiella Pneumoniae Carbapenemase-Producing Bacteria (KPC). ( 29905925 )	De LeA^n-BorrA!s R....Guiot H.M.	2018
31	Maternal Influenza Immunization and Prevention of Severe Clinical Pneumonia in Young Infants: Analysis of Randomized Controlled Trials Conducted in Nepal, Mali, and South Africa. ( 29443825 )	Omer S.B....Wairagkar N.	2018
32	Pre-stroke undiagnosed dysphagia lusoria as a rare cause of aspiration pneumonia with respiratory failure in a stroke patient. ( 29552342 )	Spatenkova V....Jedlicka J.	2018
33	Community-acquired bacterial pneumonia in adult HIV-infected patients. ( 29976111 )	CillA^niz C....Torres A.	2018
34	Monomicrobial Klebsiella pneumoniae necrotizing fasciitis: an emerging life-threatening entity. ( 29787886 )	Rahim G.R....Singh M.P.	2018
35	Serial chest CT in cryptogenic organizing pneumonia: Evolutional changes and prognostic determinants. ( 28960643 )	Chung M.P....Kim T.J.	2018
36	Community acquired <i>Klebsiella pneumoniae</i> meningitis: a case report. ( 29951382 )	Lee B....Akella J.	2018
37	Tuberculous pleurisy mimicking Mycoplasma pneumoniae infection in a previously healthy young adult: A case report. ( 29768381 )	Yaguchi D....Ito M.	2018
38	Empirical antibiotic treatment for children suffering from dysentery, cholera, pneumonia, sepsis or severe acute malnutrition. ( 29790843 )	Ashorn P.	2018
39	Acute eosinophilic pneumonia in the deployed military setting. ( 29605194 )	Sine C.R....Osborn E.C.	2018
40	One-Year Risk of Pneumonia and Mortality in Patients with Poststroke Dysphagia: A Nationwide Population-Based Study. ( 29395642 )	Ho C.H....Hung Y.C.	2018
41	Ventilator associated pneumonia caused by <i>Raoultella ornithinolytica</i> in two immunocompetent trauma patients. ( 29977781 )	Van Cleve J.R....Croce M.A.	2018
42	Guillain-BarrAc syndrome and optic neuritis after Mycoplasma pneumoniae infection. ( 29429558 )	Matsunaga M....Kawano Y.	2018
43	OK-432 pleurodesis for the treatment of pneumothorax in patients with interstitial pneumonia. ( 29903606 )	Ogawa K....Kishi K.	2018
44	<i>S. maltophilia</i> pneumonia: A case report. ( 29977756 )	Geller M....Nigri R.	2018
45	Clinical Characteristics of Pneumonia in Chinese Hemodialysis Patients. ( 29451161 )	Liu J....Fu P.	2018
46	A case of cocaine-induced eosinophilic pneumonia: Case report and review of the literature. ( 29487790 )	Reyes F....Al-Ajam M.	2018
47	A recurrent case of eosinophilic pneumonia with high IL-25 levels. ( 29779833 )	Ikeda M....Oka M.	2018
48	Bacteriological testing and recurrence prevention efforts in the diagnosis and treatment of nursing- and healthcare-associated pneumonia and aspiration pneumonia: A questionnaire survey of hospitals across Japan. ( 29548653 )	Kenzaka T....Yahata S.	2018
49	Estimating the distribution of morbidity and mortality of childhood diarrhea, measles, and pneumonia by wealth group in low- and middle-income countries. ( 29970074 )	Chang A.Y....Verguet S.	2018
50	Viral and bacterial co-infection in hospitalised children with refractory Mycoplasma pneumoniae pneumonia. ( 29970200 )	Zhang X....Yan Y.	2018

Sources

Genes for Pneumonia

Genes related to Pneumonia (0 elite genes):

(show all 33)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	LINC02258	Long Intergenic Non-Protein Coding RNA 2258 These novel lncRNAs and their target genes may be closely associated with the progression of pneumonia. Dysfunction Pattern:	RNA Gene	159.87	Experimental evidence ³⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)	27663962
2	SKAP1-AS1	SKAP1 Antisense RNA 1 These novel lncRNAs and their target genes may be closely associated with the progression of pneumonia. Dysfunction Pattern:	RNA Gene	159.85	Experimental evidence ³⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)	27663962
3	CRP	C-Reactive Protein	Protein Coding	34.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7705110 19947988 12369494 (more) 18331385 16395099 19330269 16615014 9163657 19703436 7587431 11484399 18443549 12830562 19548923 17132293 15078743 12762360 9876948 17727747 17684211 18328306 1896976 18174874 16490683 12450903 17297204 20069274 16479314 17263297 12847531 11259234 20222830 19291458 19729453 2219834 7578719 9271034 14514149 15863636 16956405 19438643 17206326 16879241 16535928 15979984 15754766 15250234 9200269 1527807 11421413 18341874 18208852 15491381 15353049 14533984 11952722 8588135 8362226 19608588 18403669 17005301 12185555 10959648 10917215 9659534 7699968 1410956 20232049 19124359 17295657 15012871 14752280 12573986 12578155 7538456 8339642 1294663 20421535 19820590 19728551 19436688 17706037 17603232 17487253 17389162 17394651 19953248 19778289 17916178 17296292 15293075 12195875 10875038 1698210 19949732 19074757 18508833 17959641 17659879
4	CD40LG	CD40 Ligand	Protein Coding	33.96	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
5	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	32.93	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
6	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	32.89	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8406851 11269653 9108184 (more) 17132293 8942140 8396001 8553296 8542140 8240932 9116985 9551728 16427093 19592208 1635109 8292374 7597268 8725256 8880103 9632909 9747602 10217667 7639556 9596098 10930308 11125305 1931078 19751843 19051345 19124359 18306021 14717657 8276881 19286926 19234101 19825784 18289803 16979119 15946834 16356255 11399697 9452482 19109244 16280065 10502562 16484918 15530478 10722871 10380089 8870709 8831305 8776260 7697231 19608588 18808711 18434235 14729508 12687258 11015126 12576957
7	TNF	Tumor Necrosis Factor	Protein Coding	31.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8339624 8002082 20416219 (more) 10650487 10607801 15112034 16053722 17665457 16096455 9596098 11910508 20222830 11334131 10507593 19522764 18322603 18088554 9730797 7750329 12496444 7512599 7587431 9134379 11985512 15863491 16882521 19501793 7632260 12576957 10550743 18800289 17711485 16100155 11401880 9632909 9607545 8880103 7679346 20300512 19608588 17609600 12746045 12687258 11053014 8360489 8128397 15278730 15072171 12840786 12162440 11880314 11837792 11350806 9736031 8575077 1487315 1888449 19962977 18565304 17384464 16113527 15908390 9742856 9271310 8942140 8530142 8928812 1395103 19051345 18959120 17069202 17051484 17043542 15863490 19551384 19931545 19762564 19906833 18097057 17681786 16484918 11275417 11133493 10657935 10573228 9876948 8870709 8831305 8787659 8776260 19583105 19234811 18431286 17659879 17569779 17644942 16622728 15805183 19592208
8	IL6	Interleukin 6	Protein Coding	31.73	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8212159 10507593 8588135 (more) 9876948 12195875 19173740 17132293 10650487 16053722 9108183 15078004 9632909 16373294 10343632 9730797 7750329 16484918 15557085 11421413 11334131 9596098 10607801 7587431 9134379 18192501 19592208 15863490 15072171 9817523 9717678 19762564 19234101 16024721 11259234 19373054 18088554 16356255 12554901 11919079 11889308 11399697 11349058 10367769 19962977 19373130 16280065 10917215 9366763 19124359 18784579 18306021 17198094 16535928 12687258 8128397 17659879 12576957 11834998 19473627 16891801 7679346 20461686 19608588 8953509 8880103 19181604 15863491 15221617 10330798 15071382
9	SFTPD	Surfactant Protein D	Protein Coding	30.92	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19439011 14522914 20133924 (more) 12479105 12865068 12654779 11925922 11306442 17925426 19254864 14612363 20228064 18226251 18266831 16406431 10969075 18628238
10	ELANE	Elastase, Neutrophil Expressed	Protein Coding	30.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	18250185 18380809 15657461 (more) 8542140 2367400 1315965 10213466 19567118 17296292 18190582 19679607 1384826 1611268 18840548 15771699 12934194 7538456 11485631 10471600 10380089 2225886 15764720 15131125 12594060 15008988 8865527 7480982 7699968 7930030 11579532 17454103 1626805 8143811 9201260 11891608 18192590
11	IL10	Interleukin 10	Protein Coding	30.13	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12746045 16162776 10588626 (more) 15078004 19234462 19421001 12554901 15762932 8897903 11421413 17472748 19181604 19592208 19608588 11713101 11349058 20195541 16280065 16186238 12379886 11031340 16495544 15021051 16356255 12687258 17659879 12463318 15377888 15696103 10343632 10382951
12	IL1B	Interleukin 1 Beta	Protein Coding	30.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8002082 12626989 9108183 (more) 15668323 10507593 9134379 15047567 16813970 10607801 19097983 11334131 19608588 19954533 19051345 9475356 7750329 19234101 17681786 16024721 8870709 7679346 19265174 18088554 16356255 11919079 11399697 9372670 20035239 16280065 9576388 12746045 8584379 16100155 19592208 1805192 9607545 9632909
13	MPO	Myeloperoxidase	Protein Coding	29.22	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1315965 10956629 10096975 (more) 12406846 20386278 15371093 16534192 8047717 16362882 16387805 12888449 19234101 17615388 18959120 10051077 10212109 11269653 14527178 15908390 17384464 20364135
14	TLR5	Toll Like Receptor 5	Protein Coding	29.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Proteins (show sections)	9323622 18490781 14623910
15	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	28.95	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19951473 10623560 18705004 (more) 19060230 10515417 15681820 17967906
16	TLR2	Toll Like Receptor 2	Protein Coding	28.4	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19109203 16272176 18356744 (more) 18237405 19956717 18359883 15656985 17169030 18403723
17	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	28.27	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7767561 11292021 12172542 (more) 11509626 10887314 17610842 10069883
18	TREM1	Triggering Receptor Expressed On Myeloid Cells 1	Protein Coding	28.25	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16960786 15332392 17659879 (more) 19596984
19	SFTPC	Surfactant Protein C	Protein Coding	28.2	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	10424594 18804975 19304906
20	CSF3	Colony Stimulating Factor 3	Protein Coding	20.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17443546 14584011 15128727 (more) 15266532 16503423 9644302 12556011 10573067 9324281 8553296 9649199 11281052 9198845 1716093 18341038 7527651 7531296 9491843 20236481 7496088 9560055 8870709 1698896 20300512 17039277 10885427 8589364 7524599 15320896 16374383 11399697 18318251 16966286 11959056 7542203 7536478 12835916 9170417 7512853 15737951 7683499 15073689 12576978 7545637 7823397 7514821 13129598
21	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	18.96	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12746045 11161432 15254170 (more) 18345025 8870709 17610842 10753501 12595446
22	CXCL2	C-X-C Motif Chemokine Ligand 2	Protein Coding	18.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15320896 19522764
23	TLR4	Toll Like Receptor 4	Protein Coding	18.17	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19925653 19956717 16272176 (more) 17947709 15656985 18403723 19409098 17618294 18356744 18237405
24	IL5	Interleukin 5	Protein Coding	18.14	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	10030835 11686868 16013770 (more) 9399955 17400729 14618645 10030847 10228042 8409120 20195541 11591797 18768888 17531296 18024909 12172542 11292021
25	IL13	Interleukin 13	Protein Coding	18.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	20416219 17379289 17400729 (more) 14657862 18951297 19695190 12172542 18337474 11591797 11884467 10226071 11781348 19531470 17610842 18768888 19175798 11893713 20477017
26	MBL2	Mannose Binding Lectin 2	Protein Coding	18.1	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17711490 17083312 16879241 (more) 19438602 18641104 15449036 19411612 20298369 19804807 15249448 18637104 17064281 19303524 18988662 17665457 19430499 12581190 16373252 15802163 18031556 18582923 17143875 18462622 10897301
27	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	17.7	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16457334 10502943 11845660 (more) 18038919 8059143 19498124
28	SFTPB	Surfactant Protein B	Protein Coding	17.49	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16024721 15190959 14718442 (more) 19201882 11919079 18403350 10445627
29	TLR9	Toll Like Receptor 9	Protein Coding	17.25	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
30	LACTB	Lactamase Beta	Protein Coding	16.94	Novoseek inferred ⁵⁵ GeneCards inferred via

Pneumonia

Aliases & Classifications for Pneumonia

MalaCards integrated aliases for Pneumonia:

Classifications:

External Ids:

Summaries for Pneumonia

Related Diseases for Pneumonia

Diseases in the Pneumonia family:

Diseases related to Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Pneumonia:

Symptoms & Phenotypes for Pneumonia

UMLS symptoms related to Pneumonia:

MGI Mouse Phenotypes related to Pneumonia:

Drugs & Therapeutics for Pneumonia

PubMedHealth treatment related to Pneumonia: 63

FDA approved drugs:

Drugs for Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: pneumonia

Genetic Tests for Pneumonia

Genetic tests related to Pneumonia:

Anatomical Context for Pneumonia

MalaCards organs/tissues related to Pneumonia:

Publications for Pneumonia

Articles related to Pneumonia:

Genes for Pneumonia

Genes related to Pneumonia (0 elite genes):

PubMedHealth treatment related to Pneumonia: ⁶³

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :