MCID: PNM007
MIFTS: 71

Pneumonia

Categories: Infectious diseases, Respiratory diseases

Summaries for Pneumonia

MedlinePlus : 43 Pneumonia is an infection in one or both of the lungs. Many germs, such as bacteria, viruses, and fungi, can cause pneumonia. You can also get pneumonia by inhaling a liquid or chemical. People most at risk are older than 65 or younger than 2 years of age, or already have health problems. Symptoms of pneumonia vary from mild to severe. See your doctor promptly if you Have a high fever Have shaking chills Have a cough with phlegm that doesn't improve or gets worse Develop shortness of breath with normal daily activities Have chest pain when you breathe or cough Feel suddenly worse after a cold or the flu Your doctor will use your medical history, a physical exam, and lab tests to diagnose pneumonia. Treatment depends on what kind you have. If bacteria are the cause, antibiotics should help. If you have viral pneumonia, your doctor may prescribe an antiviral medicine to treat it. Preventing pneumonia is always better than treating it. Vaccines are available to prevent pneumococcal pneumonia and the flu. Other preventive measures include washing your hands frequently and not smoking. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Pneumonia, also known as acute pneumonia, is related to mycoplasma pneumoniae pneumonia and bacterial pneumonia, and has symptoms including fever, pruritus and hemoptysis. An important gene associated with Pneumonia is TTR (Transthyretin), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Calcium carbonate and Magnesium citrate have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing.

CDC : 3 Pneumonia is an infection of the lungs that can cause mild to severe illness in people of all ages. Depending on the cause, doctors often treat pneumonia with medicine. In addition, vaccines can prevent some types of pneumonia. However, it is still the leading infectious cause of death in children younger than 5 years old worldwide. Common signs of pneumonia include cough, fever, and difficulty breathing. You can help prevent pneumonia and other respiratory infections by following good hygiene practices. These practices include washing your hands regularly and disinfecting frequently touched surfaces. Making healthy choices, like quitting smoking and managing ongoing medical conditions, can also help prevent pneumonia.

PubMed Health : 63 About pneumonia: Pneumonia (nu-MO-ne-ah) is an infection in one or both of the lungs. Many germs—such as bacteria, viruses, and fungi—can cause pneumonia. The infection inflames your lungs' air sacs, which are called alveoli (al-VEE-uhl-eye). The air sacs may fill up with fluid or pus, causing symptoms such as a cough with phlegm (a slimy substance), fever, chills, and trouble breathing.

Wikipedia : 75 Pneumonia is an inflammatory condition of the lung affecting primarily the small air sacs known as... more...

Related Diseases for Pneumonia

Diseases in the Pneumonia family:

Viral Pneumonia Bacterial Pneumonia

Diseases related to Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2080)
# Related Disease Score Top Affiliating Genes
1 mycoplasma pneumoniae pneumonia 35.6 TNF TLR2 IL6 IL10 CRP
2 bacterial pneumonia 35.3 TLR4 SFTPD IL6 ELANE CXCL8 CRP
3 idiopathic interstitial pneumonia 35.0 SFTPD SFTPC MUC5B ELANE CXCL8 CCL2
4 pneumocystosis 34.9 TNF SFTPD CD40LG
5 pulmonary fibrosis, idiopathic 34.0 TNF SFTPD SFTPC MUC5B IL1B ELANE
6 bronchiolitis obliterans 33.9 TNF IL6 IL10 CXCL8
7 avian influenza 33.7 TNF SFTPD IL6 CXCL8
8 q fever 33.5 TNF TLR4 TLR2 IL6 IL1B IL10
9 legionellosis 33.5 TNF TLR4 TLR2 IL1B
10 bronchiolitis 33.4 TNF TLR4 MUC5B IL6 IL10 CXCL8
11 melioidosis 33.3 TREM1 TNF TLR4 TLR2 IL6 IL10
12 invasive aspergillosis 33.3 TLR4 TLR2 SFTPD CXCL8
13 respiratory failure 33.2 TTR TNF SFTPD SFTPC ELANE CXCL8
14 myeloma, multiple 33.2 TNF IL6 CXCL8 CRP
15 pulmonary hemosiderosis 33.1 MUC5B MPO CRP
16 bacterial meningitis 33.1 TNF TLR2 IL6 IL1B IL10 CXCL8
17 silicosis 33.1 TNF SFTPD IL1B CXCL8 CCL2
18 adult respiratory distress syndrome 33.1 TNF SFTPC IL6 IL10 ELANE CXCL8
19 extrinsic allergic alveolitis 33.0 SFTPD MPO IL6 IL1B IL10 CXCL8
20 toxic shock syndrome 33.0 TREM1 TNF TLR4 TLR2 IL6 IL1B
21 common variable immunodeficiency 32.9 TNF TLR2 IL6 IL10 FOXP3 CD40LG
22 bronchitis 32.9 TNF MPO ELANE CXCL8 CRP
23 haemophilus influenzae 32.9 TNF TLR2 IL1B CXCL8
24 interstitial lung disease 32.8 TNF SFTPD SFTPC MUC5B IL6 IL1B
25 chlamydia 32.7 TNF TLR4 TLR2 IL6 IL1B IL10
26 acquired immunodeficiency syndrome 32.5 TNF IL6 IL1B IL10
27 pulmonary tuberculosis 32.4 TNF TLR2 IL10
28 exanthem 32.4 TNF IL6 CRP
29 lung disease 32.3 TNF TLR2 SFTPD SFTPC MUC5B MPO
30 pulmonary fibrosis 32.3 SFTPD SFTPC MUC5B IL1B CCL2
31 acute cystitis 32.3 IL6 CXCL8 CRP CCL2
32 otitis media 32.2 TNF TLR4 TLR2 MUC5B IL6 IL1B
33 connective tissue disease 32.2 TNF SFTPD IL6 IL10 CD40LG
34 atherosclerosis susceptibility 32.1 TNF TLR4 IL6 CRP CCL2
35 meningitis 32.1 TNF TLR2 IL6 IL1B IL10 CXCL8
36 cerebrovascular disease 32.1 TNF TLR4 IL6 CRP
37 hematopoietic stem cell transplantation 32.1 TNF IL6 IL10
38 pericarditis 32.1 TNF IL6 IL1B CRP
39 bronchiectasis 32.1 TLR2 MPO ELANE CXCL8
40 acute respiratory distress syndrome 32.1 TNF SFTPD SFTPC IL6 IL1B ELANE
41 pharyngitis 32.1 IL1B CXCL8 CRP
42 endocarditis 32.0 TNF TLR2 IL6 IL10 CXCL8 CRP
43 pertussis 32.0 TNF TLR4 IL6 IL1B IL10
44 graft-versus-host disease 31.9 TNF IL6 IL1B IL10
45 osteomyelitis 31.9 TNF IL6 IL1B IL10 CXCL8
46 septic arthritis 31.9 TLR4 TLR2 CXCL8 CRP
47 pulmonary edema 31.9 TNF IL1B IL10 CXCL8 CRP
48 fasciitis 31.9 TNF IL6 CXCL8
49 aspergillosis 31.9 TNF TLR4 TLR2 SFTPD IL10 ELANE
50 duodenal ulcer 31.9 TNF IL1B CXCL8

Graphical network of the top 20 diseases related to Pneumonia:



Diseases related to Pneumonia

Symptoms & Phenotypes for Pneumonia

UMLS symptoms related to Pneumonia:


fever, pruritus, hemoptysis, snoring, coughing

MGI Mouse Phenotypes related to Pneumonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 CD40LG CRP ELANE FOXP3 IL10 IL1B
2 hematopoietic system MP:0005397 10.22 CD40LG ELANE FOXP3 IL10 IL1B IL6
3 immune system MP:0005387 10.22 CCL2 CD40LG CRP ELANE FOXP3 IL10
4 cardiovascular system MP:0005385 10.21 CD40LG CRP FOXP3 IL10 IL1B IL6
5 mortality/aging MP:0010768 9.97 CD40LG ELANE FOXP3 IL10 IL1B IL6
6 integument MP:0010771 9.86 CD40LG FOXP3 IL10 IL1B IL6 TLR2
7 neoplasm MP:0002006 9.61 ELANE IL10 IL1B IL6 SFTPC TLR2
8 respiratory system MP:0005388 9.28 FOXP3 IL10 IL6 MUC5B SFTPC SFTPD

Drugs & Therapeutics for Pneumonia

PubMed Health treatment related to Pneumonia: 63

Treatment for pneumonia depends on the type of pneumonia you have and how severe it is. Most people who have community-acquired pneumonia—the most common type of pneumonia—are treated at home. The goals of treatment are to cure the infection and prevent complications.

Drugs for Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 855)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium carbonate Approved, Investigational Phase 4 471-34-1
2
Magnesium citrate Approved Phase 4 3344-18-1
3
Magnesium oxide Approved Phase 4 1309-48-4 14792
4 Cranberry Approved, Investigational Phase 4
5
Arsenic trioxide Approved, Investigational Phase 4 1327-53-3 518740
6
Doripenem Approved, Investigational Phase 4 148016-81-3 73303
7
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
8
Lumefantrine Approved Phase 4 82186-77-4 6437380
9
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
10
Etanercept Approved, Investigational Phase 4 185243-69-0
11
Oseltamivir Approved Phase 4 204255-11-8, 196618-13-0 65028
12
Oxacillin Approved, Investigational Phase 4 66-79-5 6196
13
Budesonide Approved Phase 4 51333-22-3 63006 5281004
14
Sucralfate Approved Phase 4 54182-58-0
15
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
16
Dibekacin Approved Phase 4 34493-98-6
17
Cefoxitin Approved Phase 4 35607-66-0 441199
18
Netilmicin Approved, Investigational Phase 4 56391-56-1 441306 6857423
19
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
20
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
21
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
22
Haloperidol Approved Phase 4 52-86-8 3559
23
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
24
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
25
Desflurane Approved Phase 4 57041-67-5 42113
26
Mupirocin Approved, Investigational, Vet_approved Phase 4 12650-69-0 446596
27
Probenecid Approved, Investigational Phase 4 57-66-9 4911
28
Mivacurium Approved Phase 4 133814-19-4, 106791-40-6 5281042
29
Tazobactam Approved Phase 4 89786-04-9 123630
30
Piperacillin Approved Phase 4 66258-76-2 43672
31
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
32
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
33
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
34
Meropenem Approved, Investigational Phase 4 119478-56-7, 96036-03-2 64778 441130
35
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
36
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
37
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
38
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
39
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
40
Sargramostim Approved, Investigational Phase 4 83869-56-1, 123774-72-1
41
Ranitidine Approved Phase 4 66357-35-5, 66357-59-3 3001055
42
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
43
Chlorpheniramine Approved Phase 4 132-22-9, 113-92-8 2725
44
Ephedrine Approved Phase 4 299-42-3 9294
45
Pseudoephedrine Approved Phase 4 90-82-4 7028
46
Esomeprazole Approved, Investigational Phase 4 119141-88-7, 161796-78-7, 161973-10-0 9568614 4594
47
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
48
Lenograstim Approved, Investigational Phase 4 135968-09-1
49
Nifedipine Approved Phase 4 21829-25-4 4485
50
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206

Interventional clinical trials:

(show top 50) (show all 3020)
# Name Status NCT ID Phase Drugs
1 Aerosolized Antibiotics in the Treatment of Ventilator Associated Pneumonia: A Pilot Study Unknown status NCT02478710 Phase 4 Aerosolized Tobramycin or Vancomycin;Aerosolized Placebo
2 Prospective Analysis of the Incidence of Ventilator-associated Pneumonia Related to the Humidification System: Heat and Moisture Exchanger Versus Heated Humidification Unknown status NCT01546974 Phase 4
3 Individualizing Duration of Antibiotic Therapy in Hospitalized Patients With Community - Acquired Pneumonia: a Non-inferiority, Randomized, Controlled Trial. Unknown status NCT01492387 Phase 4
4 Chlorhexidine Gluconate for Prevention of Ventilator Associated Pneumonia in a Pediatric Intensive Care Unit. Unknown status NCT01883596 Phase 4 0.12% chlorhexidine solution;Placebo
5 Use of the Endothelin-1 Antagonist Bosentan in Patients With Established Pulmonary Hypertension and Fibrotic Lung Disease. - A Randomised, Placebo-Controlled, Double-Blinded Study. Unknown status NCT00637065 Phase 4 Bosentan;Placebo
6 Efficacy of Methylprednisolone in Severe Community-acquired Pneumonia,A Multi-center Randomized Controlled Trial Unknown status NCT02552342 Phase 4 methylprednisolone;Normal saline
7 Randomized Controlled Trial of Fermented Dairy Product Containing L. Casei Shirota for Prevention of Ventilator-Associated Pneumonia Unknown status NCT01301131 Phase 4
8 Ventilator Associated Pneumonia: Addition of Tobramycin Inhalation Antibiotic Treatment to Standard IV Antibiotic Treatment Unknown status NCT02440828 Phase 4 tobramycin inhalation;placebo
9 Linezolid Alone or Combined With Carbapenem Against Methicillin-resistant Staphylococcus Aureus (MRSA) in Vitro and in Ventilator-associated Pneumonia Unknown status NCT01356472 Phase 4 Imipenem/cilastatin
10 SELECTIVE DIGESTIVE DECONTAMINATION USING ORAL GENTAMICIN AND ORAL POLYMYXIN E FOR ERADICATION OF CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE CARRIAGE IN HOSPITALIZED PATIENTS Unknown status NCT01761487 Phase 4
11 Immunogenicity and Reactogenicity of 10-valent Pneumococcal Conjugate Vaccine (PCV10) in Children Aged 12-59 Months Unknown status NCT01028326 Phase 4
12 Antiviral and Chinese Medicinal Herbs Treatment on Novel Influenza A (H1N1) Virus Pneumonia: Multi-centre, Prospective, Randomized Controlled Study Unknown status NCT00936013 Phase 4 oseltamivir;oseltamivir and chinese medicinal herbs
13 Pharmacokinetic and Pharmacodynamic Evaluation of Linezolid Administered Intravenously in MRSA-positive, Morbidly Obese Patients With Pneumonia Unknown status NCT01805284 Phase 4 Linezolid
14 Use Of High Dose Colistin in Multi Drug Resistant Gram Negative Infections in Critically Ill Adult Patients. Randomized Controlled Clinical Trial Unknown status NCT02162966 Phase 4 High Dose Colistin;Standard Dose Colistin
15 Comparison of the Incidence of Ventilator Associated Pneumonia in Patients Intubated With the Taper Guard Endotracheal Tube Versus a Normal Endotracheal Tube Unknown status NCT01501227 Phase 4
16 Acute Effect of Sildenafil on Exercise Tolerance and Functional Capacity in COPD, IPF and Post Pneumonectomy Patients Unknown status NCT01382368 Phase 4 Sildenafil
17 Evaluation of a Clinical Pathway Based on Procalcitonin Levels for the Management of Community-acquired Pneumonia in Outpatients Unknown status NCT02600806 Phase 4 Azithromycin;Levofloxacin
18 Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections. Can Measurement of Procalcitonin Reduce the Use of Antibiotics? Unknown status NCT02171338 Phase 4
19 A Phase IV, Randomised, Multicentre, Double-blind, Study to Evaluate the Clinical Utility of Prospective Genetic Screening (HLA-B*1301) for Susceptibility to Dapsone Hypersensitivity Syndrome Unknown status NCT02550080 Phase 4 Dapsone
20 Multi-Centre, Prospective, Open Label, Randomized Trial to Assess the Efficacy and Safety of Moxifloxacin Versus Levofloxacin Plus Metronidazole in the Treatment of Community-Acquired Pneumonia With Aspiration Factors Unknown status NCT00752947 Phase 4 moxifloxacin;levofloxacin;metronidazole
21 The Impact of Lactobacillus Preparation on the Incidence of Diarrhea in Intensive Care Unit-admitted Patients : Randomized Controlled Trial Unknown status NCT01792739 Phase 4 Lactobacillus casei variety rhamnosus granules;Placebo
22 Effect of Vitamin D Supplementation in Young Children With Acute Lower Respiratory Tract Infection at Dr George Mukhari Academic Hospital, Pretoria, South Africa Unknown status NCT02054182 Phase 4 Vitamin D
23 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
24 Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome(CTRIPS): A Prospective, Randomized, Multicenter, Double-Blind Placebo-Controlled Trial Unknown status NCT02370550 Phase 4 Cyclosporin A;Prednisone;Placebo;Calcium carbonate D
25 A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol Unknown status NCT01873521 Phase 4
26 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
27 Study of Safety, Immunogenicity and Immunological Memory of 7-valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome Unknown status NCT01346007 Phase 4
28 Optimizing Influenza Vaccination in Surgical Oncology Patients Unknown status NCT01698177 Phase 4
29 Non-Invasive Positive Pressure Mask Ventilation vs Extrathoracic Biphasic Cuirass Ventilation in Patients With Acute Respiratory Failure: A Randomized Prospective Study. Unknown status NCT00331656 Phase 4
30 Oxepa in Multiple Trauma: Prospective, Randomized, Comparative, Double-blind, Controlled Clinical Study Unknown status NCT01099501 Phase 4
31 Phase IV, Prospective, Randomized Study Comparing Preparation the Day Before and Split-dose Regimen With Sodium Picosulphate/Magnesium Citrate for Morning Colonoscopies Unknown status NCT01481714 Phase 4 Sodium picosulphate, magnesium oxid and citric acid;Sodium picosulphate/magnesium oxide and citric acid
32 A Double-blind,Randomized,Parallel,Placebo-controlled Study of Probiotics Capsule as Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy Unknown status NCT01779193 Phase 4
33 Treatment of Relapsed Acute Promyelocytic Leukemia With Arsenic Trioxide (Phase IV Study) Unknown status NCT00196768 Phase 4 Arsenic trioxide;Trisenox
34 Reinforced Sternal Closure Using Osteoconductive Biologic Bone Cement (Kryptonite) in Patients Undergoing Coronary Artery Bypass Grafting Unknown status NCT01261858 Phase 4
35 1-Year Longitudinal Follow-up Study of Serologic Responses to 7-valent Pneumococcal Conjugated Vaccination and Opsonophagocytic Activities for Streptococcus Pneumoniae Among Patients With Human Immunodeficiency Virus Infection Unknown status NCT00885625 Phase 4
36 Double-Blind Placebo-Controlled Clinical Effectiveness Trial of the 23-Valent Pneumococcal Vaccine Among Military Trainees At Increased Risk of Respiratory Disease Completed NCT02079701 Phase 4
37 Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
38 Efficacy of Toothbrushing for the Prevention of Ventilator-associated Pneumonia Completed NCT01477099 Phase 4
39 Telithromycin, Treating Adult Outpatients With Mild to Moderate Community-acquired Pneumonia (CAP) in High Bacterial Resistance Areas Completed NCT00538018 Phase 4 Telithromycin
40 Pharmacodynamic of Ceftaroline and Levofloxacin Against Pathogens Associated With Community Acquired Bacterial Pneumonia (CABP) Completed NCT01524302 Phase 4 Ceftaroline;Levofloxacin
41 Comparison of Immune Response in Pneumococcal Pneumonia and After Vaccination Completed NCT01402245 Phase 4
42 Clinical Efficacy of Amoxicillin Given Twice or Three Times a Day Among Children With Non-severe Community-acquired Pneumonia Completed NCT01200706 Phase 4 Amoxicillin
43 Phase 4, Randomized Study of Three Months-prednisolone Therapy in the Treatment of Chronic Eosinophilic Pneumonia Completed NCT00632554 Phase 4 prednisolone 0.5 mg/kg/day for three months;prednisolone 0.5 mg/kg/day for six months
44 A Phase 4, Randomized, Placebo-Controlled Clinical Trial of 13-valent Pneumococcal Conjugate Vaccine Efficacy in Prevention of Vaccine-Serotype Pneumococcal Community-Acquired Pneumonia and Invasive Pneumococcal Disease Completed NCT00744263 Phase 4
45 Phase 4 Study of Once-Daily Intramuscular Cefepime Versus Ceftriaxone for In-Home Treatment of Nursing Home-Acquired Pneumonia Completed NCT00358202 Phase 4 cefepime;ceftriaxone
46 Digital Auscultation Tool - Development of an Innovative Approach - Using Modern Technologies - to Improve the Diagnosis of Rare Lung Diseases - Expanded Data Collection Idiopathic Pulmonary Fibrosis Completed NCT03503188 Phase 4
47 A Canadian Multicenter, Prospective, Open Label, Non-Comparative Study of the Effectiveness and Safety of Oral Telithromycin, 800mg Once Daily in the Treatment of Either Community Acquired Pneumonia or Acute Exacerbation of Chronic Bronchitis in Ambulator Completed NCT00546676 Phase 4 Telithromycin
48 AmBisome® in Combination With Caspofungin Versus AmBisome® High Dose Regimen for the Treatment of Invasive Aspergillosis in Immunocompromized Patients: Randomized Pilot Study. Completed NCT00334412 Phase 4 Ambisome;caspofungin
49 Linezolid In The Treatment Of Subjects With Nosocomial Pneumonia Proven To Be Due To Methicillin-Resistant Staphylococcus Aureus Completed NCT00084266 Phase 4 linezolid (Zyvox);vancomycin
50 A Randomized, Open Label, Multi-Center Clinical Trial, Comparing Microbiologic Response To Linezolid And Vancomycin In Ventilator-Associated Pneumonia (VAP) Due To Methicillin Resistant Staphylococcus Aureus (MRSA) Completed NCT00572559 Phase 4 Vancomycin;Linezolid

Search NIH Clinical Center for Pneumonia

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Acetylcysteine
Amikacin
Amoxicillin
Azithromycin
Bacitracin
Benzylpenicillin
Cefazolin
Cefditoren
Cefepime
Cefixime
Cefotaxime
Cefoxitin
Cefpodoxime
Cefprozil
Ceftaroline fosamil
Ceftobiprole
Ceftriaxone
Ciprofloxacin
Clarithromycin
Clindamycin
Cloxacillin
Ertapenem
Erythromycin
Gemifloxacin
Levofloxacin
Linezolid
Metronidazole
Moxifloxacin
Ofloxacin
Oxacillin
Oxygen
Phenoxymethylpenicillin
Streptomycin
Sucralfate
Sulbactam
Telavancin
Tigecycline

Cochrane evidence based reviews: pneumonia

Genetic Tests for Pneumonia

Genetic tests related to Pneumonia:

# Genetic test Affiliating Genes
1 Pneumonia 29

Anatomical Context for Pneumonia

MalaCards organs/tissues related to Pneumonia:

41
Lung, Testes, Heart, Colon, Neutrophil, Bone, Brain

Publications for Pneumonia

Articles related to Pneumonia:

(show top 50) (show all 31788)
# Title Authors PMID Year
1
Long noncoding RNA SNHG16 targets miR-146a-5p/CCL5 to regulate LPS-induced WI-38 cell apoptosis and inflammation in acute pneumonia. 38 17
31071307 2019
2
Pneumonitis and concomitant bacterial pneumonia in patients receiving pembrolizumab treatment: Three case reports and literature review. 38 17
31232972 2019
3
Clinical evaluation of the use of an mhealth intervention on quality of care provided by Community Health Workers in southwest Niger. 17
31263555 2019
4
Secretory immunoglobulin A abrogates inflammatory responses and improves mortality after pseudomonas pneumonia. 9 38
20386278 2010
5
[Serum levels of IL-13 and TNF-alpha in children with Mycoplasma pneumoniae pneumonia]. 9 38
20416219 2010
6
Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia. 9 38
19825784 2010
7
Systemic and bronchoalveolar cytokines as predictors of in-hospital mortality in severe community-acquired pneumonia. 9 38
19592208 2010
8
The impact of time on the systemic inflammatory response in pneumococcal pneumonia. 9 38
19608588 2010
9
CRP gene variation and risk of community-acquired pneumonia. 9 38
19947988 2010
10
Clinical review: the role of biomarkers in the diagnosis and management of community-acquired pneumonia. 9 38
20236471 2010
11
Role of C-reactive protein and procalcitonin in differentiation of tuberculosis from bacterial community acquired pneumonia. 9 38
19949732 2009
12
Procalcitonin kinetics in Legionella pneumophila pneumonia. 9 38
19438643 2009
13
C-reactive protein, severity of pneumonia and mortality in elderly, hospitalised patients with community-acquired pneumonia. 9 38
19729453 2009
14
Autoantibodies against bactericidal/permeability-increasing protein (BPI) in children with acute pneumonia. 9 38
19702878 2009
15
Utility of C-reactive protein in assessing the disease severity and complications of community-acquired pneumonia. 9 38
19548923 2009
16
C-reactive protein to distinguish pneumonia from acute decompensated heart failure. 9 38
19703436 2009
17
Influence of age on symptoms and laboratory findings at presentation in patients with influenza-associated pneumonia. 9 38
19150140 2009
18
Old friends: pneumonia and interleukin-6. 9 38
19373054 2009
19
Role of IL-10 deficiency in pneumonia induced by Corynebacterium kutscheri in mice. 9 38
19421001 2009
20
Suppression of pulmonary innate host defence in smokers. 9 38
18852155 2009
21
C-reactive protein and community-acquired pneumonia in ambulatory care: systematic review of diagnostic accuracy studies. 9 38
19074757 2009
22
Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism. 9 38
18988662 2009
23
Mannose-binding lectin genotypes in susceptibility to community-acquired pneumonia. 9 38
18641104 2008
24
Children with absent surfactant protein D in bronchoalveolar lavage have more frequently pneumonia. 9 38
18266831 2008
25
Usefulness of consecutive C-reactive protein measurements in follow-up of severe community-acquired pneumonia. 9 38
18508833 2008
26
Prognostic role of clinical and laboratory criteria to identify early ventilator-associated pneumonia in brain injury. 9 38
18403669 2008
27
[Pneumocystis jiroveci pneumonia during infliximab therapy]. 9 38
18565304 2008
28
Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. 9 38
18192501 2008
29
Resveratrol ameliorates Serratia marcescens-induced acute pneumonia in rats. 9 38
18174363 2008
30
Assessment of B-type natriuretic peptide in patients with pneumonia. 9 38
17916178 2008
31
C-reactive protein is an independent predictor of severity in community-acquired pneumonia. 9 38
18328306 2008
32
Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia. 9 38
18252006 2008
33
[Detection of serum Th1 and Th2 cytokines and its significance in neonates with cytomegalovirus pneumonia]. 9 38
18322603 2007
34
Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis. 9 38
17711490 2007
35
Infectious etiology modifies the treatment effect of zinc in severe pneumonia. 9 38
17684211 2007
36
Clinical and genetic risk factors for pneumonia in systemic lupus erythematosus. 9 38
17665457 2007
37
Aetiology and prediction of pneumonia in lower respiratory tract infection in primary care. 9 38
17727747 2007
38
Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. 9 38
17334246 2007
39
Effects of specific neutrophil elastase inhibitor, sivelestat sodium hydrate, in murine model of severe pneumococcal pneumonia. 9 38
17454103 2007
40
Disease severity in patients with simultaneous influenza and bacterial pneumonia. 9 38
17603232 2007
41
Emergence of Legionella pneumophila pneumonia in patients receiving tumor necrosis factor-alpha antagonists. 9 38
17051484 2006
42
[Clinical features and outcome in 84 patients with influenza pneumonia]. 9 38
17087332 2006
43
Modulation of the triggering receptor expressed on myeloid cells-1 pathway during pneumonia in rats. 9 38
16960786 2006
44
Increased serum concentration of G-CSF in cystic fibrosis patients with chronic Pseudomonas aeruginosa pneumonia. 9 38
16503423 2006
45
Serum vascular endothelial growth factor in pediatric patients with community-acquired pneumonia and pleural effusion. 9 38
16891801 2006
46
Suppression of alveolar macrophage apoptosis prolongs survival of rats and mice with pneumocystis pneumonia. 9 38
16709801 2006
47
Risk and prognostic factors of ventilator-associated pneumonia in trauma patients. 9 38
16484918 2006
48
[Diagnosis of nosocomial pneumonia: conventional and new indicators]. 9 38
17069202 2006
49
[Pseudomonas aeruginosa and Surfactant-associated Proteins A and D]. 9 38
16406431 2006
50
The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia. 9 38
16362882 2006

Variations for Pneumonia

ClinVar genetic disease variations for Pneumonia:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 FOXP3 NM_014009.3(FOXP3): c.1190G> A (p.Arg397Gln) single nucleotide variant Pathogenic rs1057520529 X:49107901-49107901 X:49251440-49251440
2 TTR NM_000371.3(TTR): c.424G> A (p.Val142Ile) single nucleotide variant Pathogenic rs76992529 18:29178618-29178618 18:31598655-31598655
3 46;XX;t(2;3)(q34;p23) Translocation Likely pathogenic

Expression for Pneumonia

Search GEO for disease gene expression data for Pneumonia.

Pathways for Pneumonia

Pathways related to Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 TTR TREM1 TNF TLR4 TLR2 MUC5B
2
Show member pathways
13.48 TNF TLR4 TLR2 IL6 IL1B IL10
3
Show member pathways
13.39 TNF IL6 IL1B IL10 CXCL8 CD40LG
4
Show member pathways
13.34 TNF IL6 IL1B IL10 CXCL8 CD40LG
5
Show member pathways
13.09 TREM1 TNF TLR4 TLR2 SFTPD IL6
6
Show member pathways
13.04 TNF TLR4 TLR2 IL6 IL1B CXCL8
7
Show member pathways
12.96 TNF IL6 IL1B IL10 FOXP3 CXCL8
8
Show member pathways
12.8 TNF TLR4 IL6 IL1B CXCL8
9
Show member pathways
12.78 TNF TLR4 TLR2 IL6 IL1B CD40LG
10
Show member pathways
12.7 TNF TLR4 TLR2 IL6 IL1B IL10
11
Show member pathways
12.68 TNF MPO IL6 IL1B IL10 CCL2
12
Show member pathways