MCID: PNM005
MIFTS: 36

Pneumonic Plague

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Pneumonic Plague

MalaCards integrated aliases for Pneumonic Plague:

Name: Pneumonic Plague 12 15 73
Secondary Pneumonic Plague 12 73
Primary Pneumonic Plague 12 73
Plague 44 73
Plague, Pneumonic 76

Classifications:



External Ids:

Disease Ontology 12 DOID:10398
ICD10 33 A20.2
ICD9CM 35 020.3 020.4 020.5
MeSH 44 D010930

Summaries for Pneumonic Plague

Disease Ontology : 12 A plague that results in infection located in lung, which results from direct inhalation of the bacillus and has symptom fever, has symptom chills, has symptom cough and has symptom difficulty breathing.

MalaCards based summary : Pneumonic Plague, also known as secondary pneumonic plague, is related to plague and bubonic plague, and has symptoms including fever, cough and chills. An important gene associated with Pneumonic Plague is LY75 (Lymphocyte Antigen 75). The drugs Streptomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, lung and testes, and related phenotype is mortality/aging.

Wikipedia : 76 Pneumonic plague is a severe lung infection caused by the bacterium Yersinia pestis. Symptoms include... more...

Related Diseases for Pneumonic Plague

Diseases related to Pneumonic Plague via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 plague 32.9 PLG SULT1A2
2 bubonic plague 29.8 HOXA1 PLG
3 leptospirosis 10.0

Symptoms & Phenotypes for Pneumonic Plague

Symptoms:

12
  • fever
  • cough
  • chills
  • difficulty breathing

UMLS symptoms related to Pneumonic Plague:


fever, pruritus

MGI Mouse Phenotypes related to Pneumonic Plague:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.17 AGPS GAP43 HOXA1 LPP LY75 PLG

Drugs & Therapeutics for Pneumonic Plague

Drugs for Pneumonic Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
2 Anti-Bacterial Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3
4 Gentamicins Phase 2, Phase 3
5
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
6
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
7 Antiparasitic Agents Phase 2
8 Antiprotozoal Agents Phase 2
9 Cytochrome P-450 Enzyme Inhibitors Phase 2
10 Cytochrome P-450 CYP1A2 Inhibitors Phase 2
11 Antimalarials Phase 2
12 Topoisomerase Inhibitors Phase 2
13 Immunologic Factors Phase 2,Phase 1
14 Vaccines Phase 2,Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment and Diagnosis of Plague Completed NCT00128466 Phase 2, Phase 3 gentamicin;streptomycin
2 A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline
3 Immunogenicity and Safety of Subunit Plague Vaccine Completed NCT02596308 Phase 2
4 Safety, Tolerability & Immunogenicity of the Recombinant Plague Vaccine rF1V Completed NCT00097396 Phase 1

Search NIH Clinical Center for Pneumonic Plague

Cochrane evidence based reviews: plague

Genetic Tests for Pneumonic Plague

Anatomical Context for Pneumonic Plague

The Foundational Model of Anatomy Ontology organs/tissues related to Pneumonic Plague:

19
Lung

MalaCards organs/tissues related to Pneumonic Plague:

41
Lung, Testes, Neutrophil, T Cells, Spleen

Publications for Pneumonic Plague

Articles related to Pneumonic Plague:

(show top 50) (show all 182)
# Title Authors Year
1
Mixed pneumonic plague and nosocomial MDR-bacterial infection of lung: a rare case report. ( 29843675 )
2018
2
Pneumonic plague epidemic in Northeast China in 1910-1911: Dr. Wu Lien-Teh's epidemic preventive system for plague control. ( 29372498 )
2018
3
Investigation of Pneumonic Plague, Madagascar. ( 29260670 )
2018
4
Inhalational Gentamicin Treatment Is Effective Against Pneumonic Plague in a Mouse Model. ( 29740404 )
2018
5
Successful transplantation of guinea pig gut microbiota in mice and its effect on pneumonic plague sensitivity. ( 30280023 )
2018
6
Estimation of Pneumonic Plague Transmission in Madagascar, August-November 2017. ( 30450266 )
2018
7
Depletion of Glucose Activates Catabolite Repression during Pneumonic Plague. ( 29555700 )
2018
8
Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. ( 28220110 )
2017
9
Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice. ( 28540946 )
2017
10
Pneumonic Plague Transmission, Moramanga, Madagascar, 2015. ( 28221119 )
2017
11
Dynamics of the pneumonic plague epidemic in Madagascar, August to October 2017. ( 29162211 )
2017
12
Pneumonic plague outbreak hits cities in Madagascar. ( 28982693 )
2017
13
Immunisation of two rodent species with new live-attenuated mutants of<i>Yersinia pestis</i>CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague. ( 29263858 )
2016
14
Correction: Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis. ( 27078634 )
2016
15
Host transcriptomic responses to pneumonic plague reveal that Yersinia pestis inhibits both the initial adaptive and innate immune responses in mice. ( 27876297 )
2016
16
Pneumonic Plague: The Darker Side of Yersinia pestis. ( 26698952 )
2016
17
Plazomicin is effective in a non-human primate pneumonic plague model. ( 27614915 )
2016
18
New Insights into Autoinducer-2 Signaling as a Virulence Regulator in a Mouse Model of Pneumonic Plague. ( 27981238 )
2016
19
Temporal Progression of Pneumonic Plague in Blood of Nonhuman Primate: A Transcriptomic Analysis. ( 27003632 )
2016
20
Plague in China 2014-All sporadic case report of pneumonic plague. ( 26895880 )
2016
21
Intranasal delivery of a protein subunit vaccine using a Tobacco Mosaic Virus platform protects against pneumonic plague. ( 27745954 )
2016
22
Spatially Distinct Neutrophil Responses within the Inflammatory Lesions of Pneumonic Plague. ( 26463167 )
2015
23
Outbreak of Human Pneumonic Plague with Dog-to-Human and Possible Human-to-Human Transmission--Colorado, June-July 2014. ( 25928467 )
2015
24
Circumventing Y. pestis Virulence by Early Recruitment of Neutrophils to the Lungs during Pneumonic Plague. ( 25974210 )
2015
25
Correction: Yersinia pestis Activates Both IL-1I^ and IL-1 Receptor Antagonist to Modulate Lung Inflammation during Pneumonic Plague. ( 25970482 )
2015
26
Combinational Deletion of Three Membrane Protein-Encoding Genes Highly Attenuates Yersinia pestis while Retaining Immunogenicity in a Mouse Model of Pneumonic Plague. ( 25605764 )
2015
27
Intramuscular immunization of mice with a live-attenuated triple mutant of Yersinia pestis CO92 induces robust humoral and cell-mediated immunity to completely protect animals against pneumonic plague. ( 26446423 )
2015
28
Characterization of a Cynomolgus Macaque Model of Pneumonic Plague for Evaluation of Vaccine Efficacy. ( 26224691 )
2015
29
Primary case of human pneumonic plague occurring in a Himalayan marmot natural focus area Gansu Province, China. ( 25555623 )
2015
30
Pneumonic plague outbreak, Northern Madagascar, 2011. ( 25530466 )
2015
31
Controlling Ebola: what we can learn from China's 1911 battle against the pneumonic plague in Manchuria. ( 25722280 )
2015
32
Impact of the Pla Protease Substrate I+2-Antiplasmin on the Progression of Primary Pneumonic Plague. ( 26438794 )
2015
33
Yersinia pestis activates both IL-1I^ and IL-1 receptor antagonist to modulate lung inflammation during pneumonic plague. ( 25781467 )
2015
34
IL-17A Produced by Neutrophils Protects against Pneumonic Plague through Orchestrating IFN-I^-Activated Macrophage Programming. ( 24337746 )
2014
35
Evaluation of imipenem for prophylaxis and therapy of Yersinia pestis delivered by aerosol in a mouse model of pneumonic plague. ( 24687492 )
2014
36
Discovery of a leptospirosis cluster amidst a pneumonic plague outbreak in a miners' camp in the Democratic Republic of the Congo. ( 24514425 )
2014
37
LcrV delivered via type III secretion system of live attenuated Yersinia pseudotuberculosis enhances immunogenicity against pneumonic plague. ( 25114109 )
2014
38
Deletion of Braun lipoprotein and plasminogen-activating protease-encoding genes attenuates Yersinia pestis in mouse models of bubonic and pneumonic plague. ( 24686064 )
2014
39
Efficacy of primate humoral passive transfer in a murine model of pneumonic plague is mouse strain-dependent. ( 25097863 )
2014
40
Remote monitoring of the progression of primary pneumonic plague in Brown Norway rats in high-capacity, high-containment housing. ( 24719212 )
2014
41
A cluster of primary pneumonic plague transmitted in a truck cab in a new enzootic focus in China. ( 23509116 )
2013
42
Early apoptosis of macrophages modulated by injection of Yersinia pestis YopK promotes progression of primary pneumonic plague. ( 23633954 )
2013
43
Early host cell targets of Yersinia pestis during primary pneumonic plague. ( 24098126 )
2013
44
A non-invasive in vivo imaging system to study dissemination of bioluminescent Yersinia pestis CO92 in a mouse model of pneumonic plague. ( 23063826 )
2013
45
Establishment of a Swiss Webster mouse model of pneumonic plague to meet essential data elements under the animal rule. ( 22336286 )
2012
46
Transmission dynamics of primary pneumonic plague in the USA. ( 21733272 )
2012
47
An encapsulated Yersinia pseudotuberculosis is a highly efficient vaccine against pneumonic plague. ( 22348169 )
2012
48
Can sputum collection practices for tuberculosis improve laboratory diagnosis of pneumonic plague in developing countries? ( 22039916 )
2012
49
Phagocytes and humoral immunity to pneumonic plague. ( 22782760 )
2012
50
A comprehensive study on the role of the Yersinia pestis virulence markers in an animal model of pneumonic plague. ( 21468758 )
2011

Variations for Pneumonic Plague

Expression for Pneumonic Plague

Search GEO for disease gene expression data for Pneumonic Plague.

Pathways for Pneumonic Plague

GO Terms for Pneumonic Plague

Sources for Pneumonic Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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