MCID: PNM005
MIFTS: 47

Pneumonic Plague

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Pneumonic Plague

MalaCards integrated aliases for Pneumonic Plague:

Name: Pneumonic Plague 12 15 70 32
Secondary Pneumonic Plague 12 70
Primary Pneumonic Plague 12 70
Plague 44 70
Plague, Pneumonic 73

Classifications:



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Disease Ontology 12 DOID:10398
ICD9CM 34 020.3 020.4 020.5
MeSH 44 D010930
ICD10 32 A20.2
UMLS 70 C0032064 C0152937 C0152938 more

Summaries for Pneumonic Plague

Disease Ontology : 12 A plague that results in infection located in lung, which results from direct inhalation of the bacillus and has symptom fever, has symptom chills, has symptom cough and has symptom difficulty breathing.

MalaCards based summary : Pneumonic Plague, also known as secondary pneumonic plague, is related to septicemic plague and pharyngitis, and has symptoms including fever, cough and chills. An important gene associated with Pneumonic Plague is SULT1A2 (Sulfotransferase Family 1A Member 2), and among its related pathways/superpathways are Th17 cell differentiation and T cell receptor signaling pathway. The drugs Streptomycin and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include lung, neutrophil and t cells, and related phenotype is nervous system.

Wikipedia : 73 Pneumonic plague is a severe lung infection caused by the bacterium Yersinia pestis. Symptoms include... more...

Related Diseases for Pneumonic Plague

Diseases related to Pneumonic Plague via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 353)
# Related Disease Score Top Affiliating Genes
1 septicemic plague 30.7 VCAN SULT1A2 SERPINF2 PLG
2 pharyngitis 30.0 TNF CD8A CD4
3 lymphadenitis 29.9 TNF TLR4 CD4
4 toxic shock syndrome 29.8 TNF TLR4 TLR2
5 plague 29.8 VCAN TNF TLR4 TLR2 SULT1A2 SULT1A1
6 bronchopneumonia 29.5 TNF TLR4 IL17A CD8A CD4
7 respiratory failure 29.5 TNF TLR4 CD8A CD4
8 bubonic plague 29.4 VCAN TLR4 TLR2 SULT1A2 SULT1A1 SERPINF2
9 pneumonia 29.3 TNF TLR4 TLR2 IL17A
10 bacterial infectious disease 29.2 TNF TLR4 TLR2 IL17A CD4
11 disease by infectious agent 29.1 TNF TLR4 TLR2 IL17A CD8A CD4
12 tularemia 28.7 TNF TLR4 TLR2 IL17A CD8A CD4
13 livedoid vasculitis 10.3 SERPINF2 PLG
14 plasminogen deficiency, type i 10.3 SERPINF2 PLG
15 cork-handlers' disease 10.3 CD8A CD4
16 necrotic uveal melanoma 10.3 CD8A CD4
17 early yaws 10.2 CD8A CD4
18 ventilation pneumonitis 10.2 CD8A CD4
19 diffuse infiltrative lymphocytosis syndrome 10.2 CD8A CD4
20 latent syphilis 10.2 CD8A CD4
21 autoimmune lymphoproliferative syndrome, type iia 10.2 CD8A CD4
22 parapsoriasis 10.2 CD8A CD4
23 gastroduodenitis 10.2 CD8A CD4
24 primary syphilis 10.2 CD8A CD4
25 bird fancier's lung 10.2 CD8A CD4
26 variola major 10.2 CD8A CD4
27 intracranial embolism 10.2 SERPINF2 PLG
28 follicular mucinosis 10.2 CD8A CD4
29 spongiotic dermatitis 10.2 CD8A CD4
30 acute retinal necrosis syndrome 10.2 CD8A CD4
31 cholera 10.2
32 severe acute respiratory syndrome 10.2
33 anthrax disease 10.2
34 cerebral lymphoma 10.2 CD8A CD4
35 rheumatoid arthritis interstitial lung disease 10.2 TNF CD4
36 invasive malignant thymoma 10.2 CD8A CD4
37 west nile encephalitis 10.2 CD8A CD4
38 exanthema subitum 10.2 CD8A CD4
39 immunodeficiency 36 10.2 CD8A CD4
40 prosthetic joint infection 10.2 TLR4 TLR2
41 opportunistic bacterial infectious disease 10.1 TNF CD4
42 fungal keratitis 10.1 TLR4 TLR2
43 haemophilus influenzae 10.1 TNF TLR2
44 nocardiosis 10.1 TNF CD4
45 arachnoiditis 10.1 TNF CD4
46 secondary syphilis 10.1 CD8A CD4
47 toxicodendron dermatitis 10.1 TNF CD8A
48 enterocolitis 10.1 TNF TLR4
49 gastrointestinal tuberculosis 10.1 TNF CD4
50 granuloma annulare 10.1 TNF CD4

Graphical network of the top 20 diseases related to Pneumonic Plague:



Diseases related to Pneumonic Plague

Symptoms & Phenotypes for Pneumonic Plague

Symptoms:

12
  • fever
  • cough
  • chills
  • difficulty breathing

UMLS symptoms related to Pneumonic Plague:


fever; pruritus

MGI Mouse Phenotypes related to Pneumonic Plague:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.36 CD4 CD8A CTSC ERF GAP43 PLG

Drugs & Therapeutics for Pneumonic Plague

Drugs for Pneumonic Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Streptomycin Approved, Vet_approved Phase 3 57-92-1 19649
2
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
3 Gentamicins Phase 2, Phase 3
4 Anti-Bacterial Agents Phase 3
5 Anti-Infective Agents Phase 3
6 Cytochrome P-450 Enzyme Inhibitors Phase 3
7
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
8 Vaccines Phase 2
9 Immunologic Factors Phase 2
10
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
11 Gastrointestinal Agents Phase 1
12 Adjuvants, Immunologic Phase 1
13 Antacids Phase 1
14 Anti-Ulcer Agents Phase 1
15 Pharmaceutical Solutions Phase 1
16
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
17
Vitamin D3 Approved, Nutraceutical 67-97-0 5280795 6221
18 Nutrients
19 Micronutrients
20 Trace Elements
21 Vitamins
22 Calciferol
23 Hormones
24 Calcium, Dietary
25
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Gentamicin Versus Streptomycin for the Treatment of Naturally Occurring Human Plague and Evaluation of Rapid Diagnostic Test Kits for Yersinia Pestis Completed NCT00128466 Phase 2, Phase 3 gentamicin;streptomycin
2 An Open-label, Randomised, Non-inferiority Trial of the Efficacy and Safety of Ciprofloxacin Versus Streptomycin + Ciprofloxacin in the Treatment of Bubonic Plague Recruiting NCT04110340 Phase 3 Ciprofloxacin;Streptomycin
3 A Randomized, Non-inferiority, Active Controlled Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin Versus Doxycycline in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline
4 Immunogenicity and Safety of Subunit Plague Vaccine Comprised by Fraction 1 Capsule (F1) and Virulence-Associated (V) Antigens: A Random Phase 2a Clinical Trial Completed NCT02596308 Phase 2
5 A Phase 2b Randomized, Single-Blinded Study to Evaluate the Safety and Immunogenicity of 80 µg Recombinant Plague Vaccine (rF1V) With and Without Adjuvant at Two Vaccination Schedules in Healthy Adult Volunteers Completed NCT01122784 Phase 2
6 A Phase 2 (a), Dose-Blinded, Block-Randomized, Dose and Schedule Selection Study to Evaluate the Immunogenicity and Safety of the Recombinant Plague Vaccine rF1V in Healthy Volunteers Completed NCT00332956 Phase 2
7 A Phase 1, Open-Label, Dose-Escalating Study to Evaluate the Safety, Tolerability and Immunogenicity of the Recombinant Plague Vaccine rF1V in Healthy Volunteers Completed NCT00097396 Phase 1
8 A Phase 1b, Multi-Centre, Parallel Group, Single Blind Study to Evaluate the Safety, Tolerability and Immunogenicity of a Recombinant Plague Vaccine (rF1 and rV Antigens) in Healthy Subjects Completed NCT00246467 Phase 1
9 A Phase I Safety and Immunogenicity Dose Escalation Trial of Plague Vaccine, Flagellin/F1/V, In Healthy Adult Volunteers Completed NCT01381744 Phase 1
10 Evaluation of Gingival Crevicular Fluid Levels of LL-37 and Serum Vitamin D3 Levels in Smoker and Non-Smoker Patients With Chronic Periodontitis Completed NCT03923218
11 Point of Care Diagnostic to Identify the Causative Agent of the Plague Recruiting NCT04688996
12 The Dental Care Revolution: Health Education Using AI or Humanized Counseling on Plague Control and Periodontal Treatment Outcome in Patients With Periodontal Disease - Pilot Study: A Randomized Controlled Trial Recruiting NCT04567030

Search NIH Clinical Center for Pneumonic Plague

Cochrane evidence based reviews: plague

Genetic Tests for Pneumonic Plague

Anatomical Context for Pneumonic Plague

The Foundational Model of Anatomy Ontology organs/tissues related to Pneumonic Plague:

19
Lung

MalaCards organs/tissues related to Pneumonic Plague:

40
Neutrophil, T Cells, Bone Marrow, Bone, Lymph Node, Spleen, Kidney

Publications for Pneumonic Plague

Articles related to Pneumonic Plague:

(show top 50) (show all 464)
# Title Authors PMID Year
1
The Manchurian Plague and COVID-19: China, the United States, and the "Sick Man," Then and Now. 61
33476233 2021
2
Single-dose intranasal subunit vaccine rapidly clears secondary sepsis in a high-dose pneumonic plague infection. 61
33531196 2021
3
History of the Plague: An Ancient Pandemic for the Age of COVID-19. 61
32979306 2021
4
Modification of the Pulmonary MyD88 Inflammatory Response Underlies the Role of the Yersinia pestis Pigmentation Locus in Primary Pneumonic Plague. 61
33257532 2021
5
Protection Elicited by Attenuated Live Yersinia pestis Vaccine Strains against Lethal Infection with Virulent Y. pestis. 61
33669472 2021
6
The Yersinia pestis GTPase BipA Promotes Pathogenesis of Primary Pneumonic Plague. 61
33257531 2021
7
Emergency Department Experience in the Multi-dimensional Prevention and Control of Pneumonic Plague in Beijing. 61
33472737 2020
8
Yersinia pestis: the Natural History of Plague. 61
33298527 2020
9
Short- and long-term humoral immune response against Yersinia pestis in plague patients, Madagascar. 61
33172393 2020
10
Deaths Associated with Pneumonic Plague, 1946-2017. 61
32946734 2020
11
Two cases of imported pneumonic plague in Beijing, China. 61
33126357 2020
12
Tn-Seq Analysis Identifies Genes Important for Yersinia pestis Adherence during Primary Pneumonic Plague. 61
32759339 2020
13
An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus streptomycin + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial. 61
32807214 2020
14
Human plague: An old scourge that needs new answers. 61
32853251 2020
15
Specific Detection of Yersinia pestis Based on Receptor Binding Proteins of Phages. 61
32727041 2020
16
A Dual Role for the Plasminogen Activator Protease During the Preinflammatory Phase of Primary Pneumonic Plague. 61
32128567 2020
17
Factors Influencing Atypical Clinical Presentations during the 2017 Madagascar Pneumonic Plague Outbreak: A Prospective Cohort Study. 61
32274983 2020
18
Rapid diagnostic tests for plague. 61
32597510 2020
19
The African Green Monkey Model of Pneumonic Plague and US Food and Drug Administration Approval of Antimicrobials Under the Animal Rule. 61
32435803 2020
20
Effect of Delaying Treatment on Efficacy of Ciprofloxacin and Levofloxacin in the African Green Monkey Model of Pneumonic Plague. 61
32435805 2020
21
Delayed diagnosis of fatal pneumonic canine plague: clinical and pathologic features in two naturally infected Colorado dogs. 61
32450913 2020
22
Activation of Heme Oxygenase Expression by Cobalt Protoporphyrin Treatment Prevents Pneumonic Plague Caused by Inhalation of Yersinia pestis. 61
32015027 2020
23
Intervention To Stop Transmission of Imported Pneumonic Plague - Uganda, 2019. 61
32134908 2020
24
Subcutaneous vaccination with a live attenuated Yersinia pseudotuberculosis plague vaccine. 61
31964555 2020
25
Protection and Safety Evaluation of Live Constructions Derived from the Pgm- and pPCP1-Yersinia pestis Strain. 61
32098032 2020
26
Modeling the Justinianic Plague: Comparing hypothesized transmission routes. 61
32352988 2020
27
Development of Anti-Yersinia pestis Human Antibodies with Features Required for Diagnostic and Therapeutic Applications. 61
33294421 2020
28
Construction of a Live-Attenuated Vaccine Strain of Yersinia pestis EV76-B-SHUΔpla and Evaluation of Its Protection Efficacy in a Mouse Model by Aerosolized Intratracheal Inoculation. 61
33014895 2020
29
Performance of plague rapid diagnostic test compared to bacteriology: a retrospective analysis of the data collected in Madagascar. 61
32000692 2020
30
Containing pneumonic plague. 61
31911406 2020
31
Single-dose combination nanovaccine induces both rapid and long-lived protection against pneumonic plague. 61
31610342 2019
32
Inhibition of Neutrophil Primary Granule Release during Yersinia pestis Pulmonary Infection. 61
31822588 2019
33
Animal Exposure and Human Plague, United States, 1970-2017. 61
31742515 2019
34
The Cyclic AMP Receptor Protein Regulates Quorum Sensing and Global Gene Expression in Yersinia pestis during Planktonic Growth and Growth in Biofilms. 61
31744922 2019
35
[A perfect pair for the brilliant masterpiece, History of Chinese Medicine-in commemoration of the 130(th) and 140(th) anniversary of the birthday of distinguished modern medical historians, K. Chimin Wong and Wu Lien-teh respectively]. 61
32564524 2019
36
A Recombinant Attenuated Yersinia pseudotuberculosis Vaccine Delivering a Y. pestis YopENt138-LcrV Fusion Elicits Broad Protection against Plague and Yersiniosis in Mice. 61
31331960 2019
37
Robust Th1 cellular and humoral responses generated by the Yersinia pestis rF1-V subunit vaccine formulated to contain an agonist of the CD137 pathway do not translate into increased protection against pneumonic plague. 61
31416643 2019
38
Postexposure Administration of a Yersinia pestis Live Vaccine for Potentiation of Second-Line Antibiotic Treatment Against Pneumonic Plague. 61
31095689 2019
39
Modeling Pneumonic Plague in Human Precision-Cut Lung Slices Highlights a Role for the Plasminogen Activator Protease in Facilitating Type 3 Secretion. 61
31085709 2019
40
A prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells. 61
31457098 2019
41
[Rapidly fatal septicemic plague secondary to undiagnosed primary bubonic plague: case report]. 61
31800948 2019
42
Quantification of low abundance Yersinia pestis markers in dried blood spots by immuno-capture and quantitative high-resolution targeted mass spectrometry. 61
31096787 2019
43
Use of bioengineered human commensal gut bacteria-derived microvesicles for mucosal plague vaccine delivery and immunization. 61
30985006 2019
44
Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination and diagnostics. 61
31252217 2019
45
Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics. 61
30940874 2019
46
Epidemiological characteristics of an urban plague epidemic in Madagascar, August-November, 2017: an outbreak report. 61
30930106 2019
47
Vaccines for emerging pathogens: from research to the clinic. 61
30993689 2019
48
Pneumonic Plague in a Dog and Widespread Potential Human Exposure in a Veterinary Hospital, United States. 61
30882315 2019
49
Yersinia pestis Exploits Early Activation of MyD88 for Growth in the Lungs during Pneumonic Plague. 61
30642901 2019
50
The rise of pneumonic plague in Madagascar: current plague outbreak breaks usual seasonal mould. 61
30632956 2019

Variations for Pneumonic Plague

Expression for Pneumonic Plague

Search GEO for disease gene expression data for Pneumonic Plague.

Pathways for Pneumonic Plague

Pathways related to Pneumonic Plague according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.39 TNF TLR4 TLR2 IL17A CD4
2
Show member pathways
11.97 TNF TLR4 TLR2 IL17A CD8A CD4
3 11.87 TNF TLR4 CD8A CD4
4 11.78 VCAN TNF TLR4 GAP43
5 11.75 TNF TLR4 TLR2
6 11.73 TNF CD8A CD4
7 11.64 TNF TLR4 TLR2 IL17A
8
Show member pathways
11.58 TLR4 TLR2 IL17A CD4
9 11.53 TNF TLR4 TLR2
10 11.46 TNF TLR4 TLR2
11 11.46 TNF IL17A CD8A CD4
12 11.39 TNF TLR4 TLR2
13 11.35 TNF TLR4 TLR2
14 11.33 TNF LY75 CD8A CD4
15
Show member pathways
10.9 TNF TLR4 TLR2 IL17A CD4
16 10.66 SERPINF2 PLG
17 10.08 SULT1A2 SULT1A1

GO Terms for Pneumonic Plague

Cellular components related to Pneumonic Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.92 VCAN TNF SERPINF2 PLG IL17A HTRA1
2 extracellular region GO:0005576 9.91 VCAN TNF SERPINF2 PLG IL17A HTRA1
3 collagen-containing extracellular matrix GO:0062023 9.55 VCAN SERPINF2 PLG HTRA1 CTSC
4 cell surface GO:0009986 9.43 TNF TLR4 TLR2 SERPINF2 PLG CD4
5 external side of plasma membrane GO:0009897 9.1 TNF TLR4 LY75 IL17A CD8A CD4

Biological processes related to Pneumonic Plague according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.88 TNF TLR4 TLR2 LY75 IL17A
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 TNF TLR4 SERPINF2 CD4
3 defense response to Gram-positive bacterium GO:0050830 9.81 TNF TLR2 IL17A
4 positive regulation of inflammatory response GO:0050729 9.79 TNF TLR4 TLR2
5 positive regulation of tumor necrosis factor production GO:0032760 9.78 TLR4 TLR2 IL17A
6 response to organic substance GO:0010033 9.77 TNF SERPINF2 CTSC
7 defense response to Gram-negative bacterium GO:0050829 9.77 TLR4 IL17A CD4
8 positive regulation of JNK cascade GO:0046330 9.76 TNF TLR4 SERPINF2
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.71 TNF TLR4 TLR2
10 positive regulation of interferon-gamma production GO:0032729 9.7 TNF TLR4 HMSD
11 positive regulation of interleukin-8 production GO:0032757 9.69 TNF TLR4 TLR2
12 positive regulation of interleukin-1 beta production GO:0032731 9.67 TNF TLR4 IL17A
13 catecholamine metabolic process GO:0006584 9.63 SULT1A2 SULT1A1
14 ethanol catabolic process GO:0006068 9.62 SULT1A2 SULT1A1
15 I-kappaB phosphorylation GO:0007252 9.61 TLR4 TLR2
16 positive regulation of interleukin-12 production GO:0032735 9.61 TLR4 TLR2 IL17A
17 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.58 TNF TLR4
18 positive regulation of chemokine production GO:0032722 9.58 TNF TLR4 TLR2
19 cellular response to lipoteichoic acid GO:0071223 9.57 TLR4 TLR2
20 negative regulation of fibrinolysis GO:0051918 9.56 SERPINF2 PLG
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.5 TNF TLR4 TLR2
22 intestinal epithelial structure maintenance GO:0060729 9.46 TLR4 IL17A
23 positive regulation of matrix metallopeptidase secretion GO:1904466 9.37 TLR4 TLR2
24 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.33 TNF TLR4 IL17A
25 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.26 TLR4 TLR2
26 positive regulation of interleukin-6 production GO:0032755 9.26 TNF TLR4 TLR2 IL17A
27 immune response GO:0006955 9.23 TNF TLR4 TLR2 LY75 IL17A CTSC

Molecular functions related to Pneumonic Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.46 TLR4 TLR2 LY75 CD4
2 aryl sulfotransferase activity GO:0004062 9.26 SULT1A2 SULT1A1
3 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2
4 flavonol 3-sulfotransferase activity GO:0047894 8.62 SULT1A2 SULT1A1

Sources for Pneumonic Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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