MCID: PNM002
MIFTS: 28

Pneumonic Tularemia

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Pneumonic Tularemia

MalaCards integrated aliases for Pneumonic Tularemia:

Name: Pneumonic Tularemia 12 15
Pulmonary Tularemia 12 73
Bronchopneumonic Tularemia 12
Pneumonic Tularaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2122
ICD10 33 A21.2
ICD9CM 35 021.2
SNOMED-CT 68 45556008
UMLS 73 C0339946

Summaries for Pneumonic Tularemia

Disease Ontology : 12 A tularemia that is located in lungs. The bacteria are transmitted by breathing dusts or aerosols containing the organisms. The infection has symptom cough, has symptom chest has symptom pain, and has symptom difficulty breathing.

MalaCards based summary : Pneumonic Tularemia, also known as pulmonary tularemia, is related to tularemia and chronic granulomatous disease, and has symptoms including cough, difficulty breathing and chest has_symptom pain. An important gene associated with Pneumonic Tularemia is CLEC11A (C-Type Lectin Domain Containing 11A), and among its related pathways/superpathways is Binding and Uptake of Ligands by Scavenger Receptors. Affiliated tissues include lung, myeloid and neutrophil, and related phenotypes are Decreased OCT4 protein expression and Decreased OCT4 protein expression

Related Diseases for Pneumonic Tularemia

Diseases related to Pneumonic Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 tularemia 30.3 FTL STAB2 TLR2
2 chronic granulomatous disease 10.0

Symptoms & Phenotypes for Pneumonic Tularemia

Symptoms:

12
  • cough
  • difficulty breathing
  • chest has_symptom pain

GenomeRNAi Phenotypes related to Pneumonic Tularemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased OCT4 protein expression GR00184-A-2 9.58 AGPS FTL
2 Decreased OCT4 protein expression GR00184-A-5 9.58 AGPS FTL
3 Decreased OCT4 protein expression GR00184-A-7 9.58 AGPS FTL
4 Decreased NANOG protein expression GR00184-A-6 9.13 FTL
5 Decreased NANOG protein expression GR00184-A-8 9.13 AGPS FTL

Drugs & Therapeutics for Pneumonic Tularemia

Search Clinical Trials , NIH Clinical Center for Pneumonic Tularemia

Genetic Tests for Pneumonic Tularemia

Anatomical Context for Pneumonic Tularemia

MalaCards organs/tissues related to Pneumonic Tularemia:

41
Lung, Myeloid, Neutrophil

The Foundational Model of Anatomy Ontology organs/tissues related to Pneumonic Tularemia:

19
Lungs

Publications for Pneumonic Tularemia

Articles related to Pneumonic Tularemia:

(show all 37)
# Title Authors Year
1
The Cynomolgus Macaque Natural History Model of Pneumonic Tularemia for Predicting Clinical Efficacy Under the Animal Rule. ( 29670861 )
2018
2
Nanoparticle formulation of moxifloxacin and intramuscular route of delivery improve antibiotic pharmacokinetics and treatment of pneumonic tularemia in a mouse model. ( 30480992 )
2018
3
First case of severe pneumonic tularemia in an immunocompetent patient in the Netherlands. ( 28956784 )
2017
4
Protection of vaccinated mice against pneumonic tularemia is associated with an early memory sentinel-response in the lung. ( 29102170 )
2017
5
Notes from the Field: Fatal Pneumonic Tularemia Associated with Dog Exposure - Arizona, June 2016. ( 28837551 )
2017
6
The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4. ( 27939130 )
2017
7
Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice. ( 27246117 )
2016
8
Intracellular Delivery: Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice (Small 27/2016). ( 27412305 )
2016
9
Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia. ( 27926940 )
2016
10
An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia. ( 27015566 )
2016
11
Respiratory and oral vaccination improves protection conferred by the live vaccine strain against pneumonic tularemia in the rabbit model. ( 27511964 )
2016
12
Pulmonary tularemia. ( 26183889 )
2015
13
Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia. ( 26435204 )
2015
14
Pneumonic tularemia presenting with a vesicular eruption. ( 25942033 )
2015
15
Post-exposure immunization against Francisella tularensis membrane proteins augments protective efficacy of gentamicin in a mouse model of pneumonic tularemia. ( 22652404 )
2012
16
Pneumonic tularemia in rabbits resembles the human disease as illustrated by radiographic and hematological changes after infection. ( 21931798 )
2011
17
Histologic, immunohistochemical, microbiological, molecular biological and ultrastructural characterization of pulmonary tularemia. ( 20709464 )
2011
18
Long lived protection against pneumonic tularemia is correlated with cellular immunity in peripheral, not pulmonary, organs. ( 20688042 )
2010
19
Epitope-based vaccination against pneumonic tularemia. ( 19616492 )
2009
20
Editorial: Proinflammatory cytokines in pneumonic tularemia: too much too late? ( 19720615 )
2009
21
Inhalation of Francisella novicida Delta mglA causes replicative infection that elicits innate and adaptive responses but is not protective against invasive pneumonic tularemia. ( 18539500 )
2008
22
Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia. ( 18490759 )
2008
23
Pneumonic tularemia on Martha's Vineyard: clinical, epidemiologic, and ecological characteristics. ( 17442781 )
2007
24
Missed sentinel case of naturally occurring pneumonic tularemia outbreak: lessons for detection of bioterrorism. ( 12949036 )
2003
25
An outbreak of primary pneumonic tularemia. ( 11924660 )
2002
26
An outbreak of primary pneumonic tularemia. ( 11919317 )
2002
27
An outbreak of primary pneumonic tularemia on Martha's Vineyard. ( 11757506 )
2001
28
Pneumonic tularemia in a patient with chronic granulomatous disease. ( 9314451 )
1997
29
Ulceroglandular and pulmonary tularemia: a case resulting from a cat bite to the hand. ( 8423298 )
1993
30
Treatment of tularemia, including pulmonary tularemia, with gentamicin. ( 7352712 )
1980
31
Pneumonic tularemia on Martha's Vineyard. ( 481515 )
1979
32
Pneumonic tularemia following the shearing of a dog. ( 4672882 )
1972
33
Pulmonary tularemia. A report of five cases and consideration of pathogenesis and terminology. ( 6021119 )
1967
34
Roentgenographic manifestations of pulmonary tularemia. ( 14429517 )
1960
35
A case of pulmonary tularemia treated with aureomycin. ( 13046667 )
1953
36
Pulmonary tularemia with report of two cases. ( 18111149 )
1949
37
Pulmonary tularemia in Massachusetts; report of a case due to tick bites. ( 18906868 )
1948

Variations for Pneumonic Tularemia

Expression for Pneumonic Tularemia

Search GEO for disease gene expression data for Pneumonic Tularemia.

Pathways for Pneumonic Tularemia

Pathways related to Pneumonic Tularemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.64 FTL STAB2

GO Terms for Pneumonic Tularemia

Biological processes related to Pneumonic Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.13 AGPS FTL STAB2
2 defense response to Gram-positive bacterium GO:0050830 8.62 STAB2 TLR2

Sources for Pneumonic Tularemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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