MCID: PNM008
MIFTS: 55

Pneumothorax

Categories: Respiratory diseases
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Aliases & Classifications for Pneumothorax

MalaCards integrated aliases for Pneumothorax:

Name: Pneumothorax 11 75 53 5 43 14 71 31 33
Pleural Air Leak Nos 33
Pneumothorax Nos 33
Air Leak Nos 33

Classifications:



External Ids:

Disease Ontology 11 DOID:1673
MeSH 43 D011030
SNOMED-CT 68 196103008
ICD10 31 J93 J93.1 J93.9
UMLS 71 C0029850 C0032326

Summaries for Pneumothorax

Disease Ontology: 11 A pleural disease that is characterized as an abnormal collection of air in the pleural space between the lung and the chest wall.

MalaCards based summary: Pneumothorax, also known as pleural air leak nos, is related to pneumothorax, primary spontaneous and pleural disease, and has symptoms including hemoptysis and dyspnea. An important gene associated with Pneumothorax is FLCN (Folliculin), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Lidocaine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and lymph node, and related phenotypes are Increased cell migration and homeostasis/metabolism

Wikipedia: 75 A pneumothorax is an abnormal collection of air in the pleural space between the lung and the chest... more...

Related Diseases for Pneumothorax

Diseases related to Pneumothorax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1042)
# Related Disease Score Top Affiliating Genes
1 pneumothorax, primary spontaneous 33.7 SERPINA1 FLCN FBN1
2 pleural disease 32.1 FLCN CALB2 ALK
3 marfan syndrome 31.7 MMP2 MMP1 FBN1 ELN
4 pulmonary fibrosis 31.6 TIMP1 MMP9 MMP2 MMP1 ELN
5 loeys-dietz syndrome 31.2 FBN1 FBLN5 ELN COL5A1
6 silicosis 30.9 TIMP1 MUC1 MMP9
7 interstitial lung disease 30.9 TIMP1 NKX2-1 MUC1 MMP9
8 lymphangioleiomyomatosis 30.9 TSC1 PGR MMP9 MMP2 MMP1 GNRH1
9 sarcoma 30.8 VIM MUC1 KDR CALB2 ALK
10 endometriosis 30.8 TIMP1 PGR MMP2 MMP1 KDR GNRH1
11 bronchiolitis obliterans 30.7 TIMP1 MUC1 MMP9
12 pulmonary disease, chronic obstructive 30.7 TIMP1 SERPINA1 MMP9 MMP1 ELN
13 cryptogenic organizing pneumonia 30.7 TIMP1 MUC1 MMP9
14 pulmonary emphysema 30.7 TIMP1 SERPINA1 MMP9 MMP2 MMP1 ELN
15 alpha-1-antitrypsin deficiency 30.6 SERPINA1 MMP1 ELN
16 diaphragmatic hernia, congenital 30.6 NKX2-1 FBN1 ELN
17 lung disease 30.6 TSC1 TIMP1 SERPINA1 NKX2-1 MMP9 ELN
18 mesothelioma, malignant 30.6 VIM NKX2-1 MUC1 KDR CALB2
19 cystic fibrosis 30.5 TIMP1 SERPINA1 MUC1 MMP9 HIF1A ELN
20 malignant pleural mesothelioma 30.5 MMP9 KDR HIF1A CALB2
21 angiosarcoma 30.5 VIM MUC1 KDR HIF1A CALB2
22 ehlers-danlos syndrome, vascular type 30.5 FBN1 FBLN5 ELN
23 leiomyosarcoma 30.4 VIM PGR MUC1
24 epithelioid sarcoma 30.4 VIM MUC1 CALB2
25 large cell carcinoma 30.3 NKX2-1 MUC1 ALK
26 tracheal stenosis 30.3 NKX2-1 FBN1 ELN
27 endometrial stromal sarcoma 30.2 VIM PGR CALB2
28 ehlers-danlos syndrome 30.2 FBN1 FBLN5 ELN COL5A1
29 orthostatic intolerance 30.2 FBN1 ELN COL5A1
30 squamous cell carcinoma 30.1 NKX2-1 MUC1 MMP9 MMP2 HIF1A
31 interstitial lung disease 2 30.1 TIMP1 SERPINA1 MUC1 MMP9 MMP2 MMP1
32 kidney cancer 30.1 TSC1 KDR HIF1A FLCN
33 neurilemmoma 30.1 VIM MUC1 CALB2
34 thymic carcinoma 30.1 NKX2-1 MUC1 CALB2
35 teratoma 30.0 VIM NKX2-1 MUC1 CALB2
36 skin disease 30.0 MMP9 MMP2 MMP1 HIF1A ELN ALK
37 scoliosis 30.0 TIMP1 SERPINA1 MMP9 FBN1 FBLN5 ELN
38 pulmonary hypertension 30.0 SERPINA1 MMP2 KDR HIF1A ELN
39 wilms tumor 1 30.0 PGR NKX2-1 MUC1 CALB2
40 lipoprotein quantitative trait locus 30.0 SERPINA1 MMP9 KDR HIF1A FBN1 ELN
41 fasciitis 30.0 VIM MUC1 MMP1
42 kawasaki disease 29.9 TIMP1 MMP9 MMP2 ELN
43 lymphangioma 29.9 VIM KDR CALB2
44 collagen disease 29.9 FBN1 ELN COL5A1
45 myoma 29.8 PGR GNRH1 CALB2
46 oncocytoma 29.8 VIM MUC1 FLCN
47 adenocarcinoma 29.8 TIMP1 NKX2-1 MUC1 MMP9 MMP2 KDR
48 benign peritoneal mesothelioma 29.8 MUC1 GNRH1 CALB2
49 nephroma 29.8 VIM PGR ALK
50 lymphangitis 29.8 NKX2-1 MUC1 ALK

Graphical network of the top 20 diseases related to Pneumothorax:



Diseases related to Pneumothorax

Symptoms & Phenotypes for Pneumothorax

UMLS symptoms related to Pneumothorax:


hemoptysis; dyspnea

GenomeRNAi Phenotypes related to Pneumothorax according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 ALK CALB2 COL5A1 ELN FBLN5 FBN1
2 no effect GR00402-S-2 10.18 ALK CALB2 COL5A1 FLCN GNRH1 HIF1A
3 Increased cell migration GR00055-A-1 8.96 KDR
4 Increased cell migration GR00055-A-3 8.96 KDR

MGI Mouse Phenotypes related to Pneumothorax:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 ALK ELN FBLN5 FBN1 FLCN GNRH1
2 neoplasm MP:0002006 10.34 ALK FBLN5 FLCN GNRH1 HIF1A MMP1
3 normal MP:0002873 10.29 ALK CALB2 COL5A1 GNRH1 HIF1A KDR
4 growth/size/body region MP:0005378 10.25 ALK COL5A1 FBLN5 FBN1 FLCN GNRH1
5 nervous system MP:0003631 10.24 ALK CALB2 FBN1 GNRH1 HIF1A KDR
6 cardiovascular system MP:0005385 10.21 COL5A1 ELN FBLN5 FBN1 FLCN HIF1A
7 muscle MP:0005369 10.18 ELN FBLN5 FBN1 HIF1A KDR MMP2
8 endocrine/exocrine gland MP:0005379 10.1 ALK FBN1 GNRH1 HIF1A MMP2 MUC1
9 respiratory system MP:0005388 10.1 ALK ELN FBLN5 FBN1 HIF1A KDR
10 reproductive system MP:0005389 9.96 ALK FBN1 GNRH1 MMP2 MMP9 NKX2-1
11 skeleton MP:0005390 9.93 ALK ELN FBN1 GNRH1 HIF1A KDR
12 mortality/aging MP:0010768 9.83 ALK COL5A1 ELN FBN1 FLCN HIF1A
13 integument MP:0010771 9.4 ALK COL5A1 FBLN5 FBN1 GNRH1 HIF1A

Drugs & Therapeutics for Pneumothorax

Drugs for Pneumothorax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4
Cisatracurium Approved, Investigational Phase 4 96946-41-7 62887
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
7
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456 5824
8
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
9
Ranitidine Approved, Withdrawn Phase 4 66357-59-3, 82530-72-1, 66357-35-5 3001055 5039
10
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
12
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
13
Atropine Approved, Vet_approved Phase 4 101-31-5, 5908-99-6, 51-55-8 3661 154417 174174
14
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
15 Pulmonary Surfactants Phase 4
16
Ranitidine bismuth citrate Phase 4
17 Tea Phase 4
18 Anesthetics Phase 4
19 Analgesics Phase 4
20 Analgesics, Non-Narcotic Phase 4
21 Antirheumatic Agents Phase 4
22 Cyclooxygenase Inhibitors Phase 4
23 Anti-Inflammatory Agents, Non-Steroidal Phase 4
24 Anti-Inflammatory Agents Phase 4
25
Minocycline Approved, Investigational Phase 3 10118-90-8, 13614-98-7 54675783 5281021
26
Cefazolin Approved Phase 2, Phase 3 25953-19-9 33255
27
Clindamycin Approved, Vet_approved Phase 2, Phase 3 18323-44-9, 24729-96-2 29029
28 Anti-Infective Agents Phase 2, Phase 3
29 Anti-Bacterial Agents Phase 2, Phase 3
30 Antibiotics, Antitubercular Phase 2, Phase 3
31 Lactams Phase 2, Phase 3
32 Penicillins Phase 2, Phase 3
33
Clindamycin phosphate Phase 2, Phase 3 32603
34 Clindamycin palmitate Phase 2, Phase 3
35 Respiratory System Agents Phase 3
36
Dimenhydrinate Approved Phase 1, Phase 2 523-87-5 10660
37
Povidone-iodine Approved Phase 1, Phase 2 25655-41-8
38
Iodine Approved, Investigational Phase 1, Phase 2 7553-56-2 807
39
Povidone K30 Approved, Experimental, Withdrawn Phase 1, Phase 2 9003-39-8 6917 131751496
40
Cadexomer iodine Experimental Phase 1, Phase 2 94820-09-4
41 Anti-Infective Agents, Local Phase 1, Phase 2
42 Insulin, Globin Zinc Phase 2
43
Insulin Phase 2
44
Ropivacaine Approved 84057-95-4 71273 175805
45
Rocuronium Approved 119302-91-9, 143558-00-3 441290
46
Dexmedetomidine Approved, Experimental, Vet_approved 86347-14-0, 113775-47-6 68602 5311068
47
Ketamine Approved, Vet_approved 6740-88-1, 1867-66-9 3821
48
Nitrous oxide Approved, Vet_approved 10024-97-2 948
49
Sevoflurane Approved, Vet_approved 28523-86-6 5206
50
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337

Interventional clinical trials:

(show top 50) (show all 130)
# Name Status NCT ID Phase Drugs
1 Improving Primary Spontaneous Pneumothorax (PSP) Treatment Techniques in VATS Unknown status NCT01463553 Phase 4
2 Early Administration of Surfactant in Spontaneous Breathing (TAKE CARE) Versus InSurE (Intubation, Surfactant, Extubation) : A Pilot Study Unknown status NCT01329432 Phase 4
3 A Comparative Study Between Thoracic Epidural Anesthesia in Non-Intubated Video-Assisted Thoracoscopes and the Conventional General Anesthesia With One Lung Ventilation Active, not recruiting NCT05077111 Phase 4
4 Local Anesthesia Versus Combined Local Anesthesia With Single Dose Analgesia on Pain Control During Thoracic Ultrasound Guided Procedures Not yet recruiting NCT05121233 Phase 4 Diclofenac;Placebo
5 Comparison of Chest Tube Drainage Versus Thoracoscopic Surgery for Unsuccessful Aspiration of Primary Spontaneous Pneumothorax: a Prospective Randomized Trial Unknown status NCT00713362 Phase 2, Phase 3
6 Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax: A Randomized Trial Unknown status NCT00418392 Phase 3
7 Thoracoscopic Bullectomy With Absorbable Mesh Coverage of the Staple Line Versus Thoracoscopic Bullectomy Only for the Treatment of Primary Spontaneous Pneumothorax: a Single-blind, Parallel-group, Prospective, Randomized Controlled Trial Unknown status NCT01848860 Phase 2, Phase 3
8 Effect of Dissecting of The Inferior Pulmonary Ligament on Postoperative Pulmonary Reexpansion and Recurrence After Operation by Video-assisted Thoracic Surgery in the Treatment of Primary Spontaneous Pneumothorax(PSP) Unknown status NCT02558608 Phase 3
9 Phase III Study of Additional Minocycline Pleurodesis After Video-Assisted Thoracoscopic Surgery for Primary Spontaneous Pneumothorax Unknown status NCT00154895 Phase 3 intrapleural minocycline instillation
10 Comparison of Pleural Abrasion Plus Minocycline Pleurodesis Versus Apical Pleurectomy After Thoracoscopic Bullectomy for High Recurrent Risk Patients With Primary Spontaneous Pneumothorax: A Prospective Randomized Trial. Unknown status NCT00270751 Phase 2, Phase 3
11 A Prospective Randomized Study of 14-French (14F) Pigtail Catheters Versus 28F Chest Tubes in Patients With Traumatic Pneumothorax: Impact on Tube-Site Pain and Failure Rate Unknown status NCT01537289 Phase 3
12 Use of a Novel Chest Tube Insertion Device for Urgent Thoracostomy in an Emergency Department Setting Unknown status NCT03734471 Phase 3
13 A Prospective Randomized Multi-Centered Study and Efficacy Evaluation of the Bio-Seal Biopsy Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Procedures Completed NCT00527722 Phase 2, Phase 3
14 A Prospective, Randomized, Multi-centered Safety and Efficacy Evaluation of the Bio-Seal Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Completed NCT00562302 Phase 3
15 Phase III Study of Evaluation of the Efficacy of Additional Mechanical Pleurodesis After Thoracoscopic Wedge Resection for the Management of Primary Spontaneous Pneumothorax Completed NCT00615849 Phase 3
16 The Role of Antibiotics in the Reduction of Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax: A Prospective, Double-Blinded Study Completed NCT01127880 Phase 2, Phase 3 Ancef or Clindamycin;Placebo
17 Very Early Surfactant Without Mandatory Ventilation In Premature Infants Treated With Early Continuous Positive Airway Pressure-A Randomized Controlled Trial Completed NCT00563641 Phase 3
18 KatGuide-trial. KatGuide Method Versus Conventional Method at Insertion of Chest Tube. A Randomized, Parallel Group, Controlled Trial. Completed NCT01522885 Phase 3
19 Effect of Autologous Blood Patch Injection Versus BioSentry Hydrogel Tract Plug in the Reduction of Pneumothorax Risk Following Lung Biopsy Procedures Active, not recruiting NCT02224924 Phase 3
20 Efficacy, Safety and Re-occurrence of Pneumothorax and Hydro-pneumothorax With Talc and Pyodine Pleurodesis: A Randomized Control Trial Unknown status NCT04130451 Phase 1, Phase 2 PYODINE AND TALC SLURRY
21 Lung Deflation With Arndt® Blocker During Video-Assisted Thoracoscopy: A Comparison of the Disconnection Technique With a Continuous Bronchial Suction Completed NCT02030795 Phase 2
22 Gelfoam Slurry as an Embolization Agent of the Needle Tract to Prevent Pneumothorax From Percutaneous CT-guided Lung Biopsy: A Randomized Controlled Trial Withdrawn NCT03669003 Phase 2
23 Platelet Rich Plasma in Secondary Spontaneous Pneumothorax Unknown status NCT03830645 Phase 1
24 Prevalence of Birt-Hogg-Dubé Syndrome Among Patients With (Hereditary) Spontaneous Pneumothorax Unknown status NCT02916992 Phase 1
25 Randomized Controlled Trial on Comparison of Chest Tube Drainage and Needle Aspiration in Treatment of Spontaneous Pneumothorax Unknown status NCT03293199
26 A Comparative Study of the Safety and Efficacy of Face Talc Slurry and Iodopovidone for Pleurodesis Unknown status NCT00430664
27 Are EMS Personnel Prepared to Identify and Decompression of Tension Pneumothorax: A Randomized, Crossover Manikin Trial Unknown status NCT02709122
28 Intrapleural Minocycline After Manual Aspiration for the Prevention of Primary Spontaneous Pneumothorax. A Phase III Multicenter Prospective Randomized Controlled Trial Unknown status NCT00839553
29 The Incidence of Pneumothorax After CT-guided Lung Biopsy Performed With and Without Autologous Blood Patching: a Randomized Single-center Prospective Study Unknown status NCT03804957
30 Comparison of the Analgesic Effect Between Ultrasound-Guided Serratus Anterior Plane Block and Intercostal Nerve Block After Single Port Video-Assisted Thoracoscopic Surgery in Primary Spontaneous Pneumothorax Unknown status NCT04191850
31 To Determine the Efficacy of Autologous Blood Patch Therapy in Reducing Air Leak in Secondary Spontaneous Pneumothorax: A Proof-of-Concept Study Unknown status NCT04132687
32 Primary Spontaneous Pneumothorax and Different Types of Surgical Management Unknown status NCT03804385
33 Changes in Heart Rate Variability in Ventilated Patients Undergoing Tension Pneumothorax for Thoracoscopic Cervical Sympathectomy Unknown status NCT03537417
34 A Multi-site Randomized Controlled Study of Interventional Treatment of Refractory Pneumothorax by Bronchoscope Unknown status NCT02352012
35 PCL (Poly-ε-caprolactone) Mesh Pleurodesis in Thoracoscopic Treatment of Primary Spontaneous Pneumothorax Unknown status NCT03227978 Early Phase 1
36 Molecular Pathogenesis of Primary Spontaneous Pneumothorax Unknown status NCT01135004
37 Predictive Score of PneumOThorax Secondary to CT-guided Transthoracic Lung Biopsy Made From a Large Retrospective Cohort and Validated on a Prospective Cohort Unknown status NCT03488043
38 Use of Endobronchial Ultrasound Scope (EBUS) Transducer to Identify Pneumothorax-A Feasibility Study Unknown status NCT02907866
39 Training Thoracic Ultrasound Skills: a Multicentre, Blinded, Randomized Controlled Trial of Simulation-based Training Versus Training on Healthy Figurants Unknown status NCT03728491
40 Mechanical Ventilation During Cardiac Surgery, a Randomized Controlled Trial Unknown status NCT02090205
41 A Randomized, Controlled Trial of the Use of a Dedicated Ballooned Intercostal Tube Unknown status NCT03000504
42 Suturing With U-technique Versus Un-Reapproximated Wound Edges During Removal of Closed Thoracostomy Tube Drain - A Single-centre Open-label Randomized Prospective Trial (SUTURE TRIAL) Unknown status NCT04193241
43 Improvement and Clinical Application of a New Minimally Invasive Closed Thoracic Drainage System Unknown status NCT04143360
44 Video-guided Percutaneous Tracheostomy (PCT): Evaluating the Safety, Efficacy and Simplicity of a Novel Technique Unknown status NCT01013298
45 Video-guided Percutaneous Tracheostomy (PCT): Evaluating the Safety, Efficacy and Simplicity of a Novel Technique, Compared to Conventional PCT Unknown status NCT01012518
46 A Prospective Randomised Study of Efficacy, Safety and Costs of Talc Pleurodesis Under Medical Thoracoscopy and Pleurodesis Under Video-assisted Thoracoscopy Surgery for Recurrent Primary Spontaneous Pneumothorax Completed NCT00767962
47 Comparative Study of Single Port Thoracoscopic Bullectomy Under Nonintubated Local and Sedation Anesthesia Versus Intubated General Anesthesia for Primary Spontaneous Pneumothorax. Completed NCT02109510 nonintubated sedation anesthesia with dexmedetomidine IV, ketamine IV and intercostal nerve block with lidocaine infiltration;intubated general anesthesia with propofol IV, rocuronium IV ,sevoflurane and N2O gas
48 Is Lung Ultrasound the Technique of Choice for the Diagnosis of Pneumothorax Following the Nuss Procedure for Pectus Excavatum? Completed NCT03073616
49 Occult Pneumothorax in Patients With Blunt or Penetrating Trauma: A Descriptive, Cross-sectional Study Completed NCT04188938
50 Comparison Of Chest Ultrasound Techniques To Identify Clinically Significant Pneumothorax Completed NCT02619591

Search NIH Clinical Center for Pneumothorax

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Talc

Cochrane evidence based reviews: pneumothorax

Genetic Tests for Pneumothorax

Anatomical Context for Pneumothorax

Organs/tissues related to Pneumothorax:

MalaCards : Lung, Heart, Lymph Node, Liver, Breast, Bone Marrow, Trachea

Publications for Pneumothorax

Articles related to Pneumothorax:

(show top 50) (show all 24177)
# Title Authors PMID Year
1
A Japanese family with multiple lung cysts and recurrent pneumothorax: a possibility of Birt-Hogg-Dubé syndrome. 53 62
19687589 2009
2
Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. 53 62
18663353 2008
3
Mutations of the Birt Hogg Dube gene in patients with multiple lung cysts and recurrent pneumothorax. 53 62
17496196 2007
4
Birt-Hogg-Dubé (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability. 53 62
16870330 2007
5
Novel mutations in the BHD gene and absence of loss of heterozygosity in fibrofolliculomas of Birt-Hogg-Dubé patients. 53 62
17124507 2007
6
Birt-Hogg-Dubé gene mutations in human endometrial carcinomas with microsatellite instability. 53 62
16691634 2006
7
Emerging clinical picture of lymphangioleiomyomatosis. 53 62
16055626 2005
8
Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults. 53 62
15805188 2005
9
Robotic Bronchoscopy for the Diagnosis of Pulmonary Lesions. 62
36372527 2023
10
Point-of-care ultrasound use in emergencies: what every anaesthetist should know. 62
36449358 2023
11
Rib spur causing a hemothorax, pneumothorax, and diaphragmatic injury in a pediatric patient. 62
36388615 2023
12
Instant and Tough Adhesives for Rapid Gastric Perforation and Traumatic Pneumothorax Sealing. 62
36148602 2022
13
Response to letter to the editor original article: Not so FAST-chest ultrasound underdiagnoses traumatic pneumothorax. 62
35999658 2022
14
Low diffusion capacity of the lung predicts pneumothorax and chest drainage after CT-guided lung biopsy. 62
36457053 2022
15
Development and validation of a prediction model of pneumothorax after CT-guided coaxial core needle lung biopsy. 62
36465829 2022
16
Diagnosis of pneumothorax, non-visualized in post-anterior chest radiography, by pulmonary ultrasound. 62
36088261 2022
17
Pleural decompression procedural safety for traumatic pneumothorax and haemothorax: Kelly clamps versus fine artery forceps. 62
35618677 2022
18
Automated pneumothorax triaging in chest X-rays in the New Zealand population using deep-learning algorithms. 62
35224858 2022
19
Routine Chest Roentgenogram After Chest Tube Removal Is Not Indicated for Minimally Invasive Lung Resection. 62
34798074 2022
20
Diagnostic value of pulmonary ultrasound in acute exacerbation of chronic obstructive pulmonary disease: A pilot study. 62
35331547 2022
21
Primary repair of a completely ruptured intermediate bronchus after blunt chest trauma. Case report. 62
33624561 2022
22
Spontaneous prevertebral emphysema following weight training in a 21-year-old female. 62
36205802 2022
23
Postnatal Imaging for Prediction of Outcome in Patients with Left-sided Congenital Diaphragmatic Hernia. 62
35944713 2022
24
A rare complication of secondary pneumothorax following exploratory laparotomy for a small bowel obstruction: Case report. 62
36473270 2022
25
A case of severe hemorrhagic shock caused by traumatic avulsion of uterine fibroid. 62
36247877 2022
26
Surgical Management of Primary Spontaneous Pneumothorax Without Lung Bullae. 62
36027657 2022
27
Pressure-dependent persistent air leak in a patient with secondary spontaneous pneumothorax. 62
35787363 2022
28
A scoping review of clinical practice guidelines for the diagnosis of primary spontaneous pneumothorax. 62
36184269 2022
29
Early risk factors of operative management for hospitalization children with spontaneous pneumothorax. 62
35649747 2022
30
Not so FAST but not so furious: An improper method underdiagnoses pneumothorax-answer to the article "Not so FAST-chest ultrasound underdiagnoses traumatic pneumothorax". 62
35999666 2022
31
Vanishing Lung Syndrome, or Idiopathic Giant Bullous Emphysema, with Pneumothorax, and Subcutaneous Emphysema in a 58-Year-Old Female Smoker with Chronic Obstructive Pulmonary Disease. 62
36457206 2022
32
Regional respiratory sound abnormalities in pneumothorax and pleural effusion detected via respiratory sound visualization and quantification: case report. 62
35147849 2022
33
Neonatal pneumothorax: symptoms, signs and timing of onset in the post-surfactant era. 62
33535849 2022
34
Preoperative bullae and subsequent pneumothorax in 6605 patients who underwent robotic prostatectomy. 62
36192651 2022
35
Comparative effectiveness of calfactant and beractant in neonatal respiratory distress syndrome: A systemic review and meta-analysis. 62
36097672 2022
36
Positive 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography 20 Years after Talc Pleurodesis. 62
36398298 2022
37
Conservative medical management combined with follow-up multidetector computed tomography of tracheobronchial injury caused by penetrating injuries: A case report. 62
36247879 2022
38
Preoperative Localization for Small Pulmonary Nodules Using Anchor with Scaled Suture System. 62
36229696 2022
39
The characteristics of assaulted victims presented to a university emergency department: Can head trauma in male patients be considered a clue for assaults? 62
36453782 2022
40
Comparative analysis of electromagnetic navigation bronchoscopy versus computed tomography-guided lung puncture for the sampling of indeterminate pulmonary nodules in the middle of an anatomic lung segment: A cohort study. 62
36464771 2022
41
Using 3D polylines to improve cone-beam CT-guided percutaneous transthoracic needle biopsy. 62
36169413 2022
42
Current evidence of ultrasound-guided fascial plane blocks for cardiac surgery: a narrative literature review. 62
36245347 2022
43
ACCURACY OF PRELIMINARY PATHOLOGY FOR ROBOTIC BRONCHOSCOPIC BIOPSY. 62
36470566 2022
44
Bilateral pneumothoraces with apical consolidations. 62
36406941 2022
45
Clinical Outcomes and Patient Safety of Nasogastric Tube in Acute Stroke Patients. 62
35296916 2022
46
DeepBackRib: Deep learning to understand factors associated with readmissions after rib fractures. 62
36121263 2022
47
Endoscopic resection in the treatment of intramural esophageal bronchogenic cysts: A retrospective analysis of 17 cases. 62
36096990 2022
48
Transesophageal Echocardiography-Guided Extracorporeal Membrane Oxygenation Cannulation in COVID-19 Patients. 62
36038441 2022
49
The Effects of Body Mass Index and Seatbelt Use on Pediatric Chest and Abdominal Injuries after Motor Vehicle Collisions. 62
33870738 2022
50
Infrapedicular approach to CT-guided thermal ablation in the thoracic spine. 62
35574645 2022

Variations for Pneumothorax

ClinVar genetic disease variations for Pneumothorax:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 COL5A1 NM_000093.5(COL5A1):c.608G>T (p.Gly203Val) SNV Likely Pathogenic
523328 rs1554781700 GRCh37: 9:137593133-137593133
GRCh38: 9:134701287-134701287

Expression for Pneumothorax

Search GEO for disease gene expression data for Pneumothorax.

Pathways for Pneumothorax

Pathways related to Pneumothorax according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 ALK COL5A1 ELN FBN1 GNRH1 HIF1A
2 13.66 VIM TSC1 PGR MMP9 MMP2 KDR
3
Show member pathways
13.34 MMP9 MMP2 MMP1 KDR GNRH1 FBN1
4
Show member pathways
13.25 VIM TIMP1 MUC1 MMP9 MMP2 MMP1
5
Show member pathways
13 TIMP1 KDR GNRH1 FBN1 ELN COL5A1
6
Show member pathways
12.98 TSC1 TIMP1 KDR HIF1A GNRH1 ALK
7 12.75 PGR MMP9 KDR HIF1A COL5A1 ALK
8 12.62 HIF1A KDR MMP2 MMP9 TSC1
9
Show member pathways
12.3 TIMP1 SERPINA1 MMP2 MMP1 FBN1
10
Show member pathways
12.25 TIMP1 MMP9 MMP2 MMP1 KDR FBN1
11
Show member pathways
11.85 TIMP1 MMP9 MMP2 MMP1
12 11.81 VIM TIMP1 MMP2
13 11.76 TSC1 KDR HIF1A
14 11.75 FBN1 FBLN5 ELN
15
Show member pathways
11.73 FBN1 FBLN5 ELN
16 11.72 HIF1A KDR MMP2 MMP9 TIMP1
17 11.63 TIMP1 MMP9 MMP1 HIF1A
18
Show member pathways
11.61 MMP9 MMP2 MMP1
19 11.52 TIMP1 MMP9 MMP2 MMP1
20 11.51 MMP9 MMP2 KDR
21 11.51 TIMP1 MMP9 MMP2 MMP1 FBN1 ELN
22 11.45 TIMP1 SERPINA1 MMP9 MMP2 ELN
23 11.38 MMP9 MMP2 MMP1
24 11.3 MMP9 MMP2 MMP1
25 11.3 MUC1 MMP9 MMP1 ELN
26 11.28 HIF1A KDR MMP9
27 11.22 MMP9 MMP1 COL5A1
28 11.2 VIM TIMP1 MUC1 MMP9 MMP2 MMP1
29 10.98 HIF1A KDR MMP9
30 10.83 VIM TIMP1 KDR GNRH1 FBN1 ELN
31 10.77 VIM TIMP1 PGR
32 10.48 TSC1 HIF1A

GO Terms for Pneumothorax

Cellular components related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.22 TIMP1 SERPINA1 MUC1 MMP9 MMP2 MMP1
2 collagen-containing extracellular matrix GO:0062023 9.8 COL5A1 ELN FBLN5 FBN1 MMP2 MMP9
3 elastic fiber GO:0071953 9.56 FBLN5 ELN
4 extracellular matrix GO:0031012 9.47 TIMP1 MMP9 MMP2 MMP1 FBN1 FBLN5

Biological processes related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.91 MMP9 MMP2 MMP1
2 collagen catabolic process GO:0030574 9.85 MMP9 MMP2 MMP1
3 positive regulation of macroautophagy GO:0016239 9.73 HIF1A KDR TSC1
4 glandular epithelial cell maturation GO:0002071 9.71 PGR HIF1A
5 negative regulation of TOR signaling GO:0032007 9.63 TSC1 HIF1A FLCN
6 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.62 TIMP1 HIF1A
7 extracellular matrix organization GO:0030198 9.61 MMP9 MMP2 MMP1 ELN COL5A1
8 cellular response to UV-A GO:0071492 9.23 TIMP1 MMP9 MMP2 MMP1

Molecular functions related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.76 KDR FBN1 FBLN5 COL5A1
2 Hsp90 protein binding GO:0051879 9.43 TSC1 KDR HIF1A
3 extracellular matrix constituent conferring elasticity GO:0030023 9.1 FBN1 FBLN5 ELN

Sources for Pneumothorax

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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