Aliases & Classifications for Pneumothorax

MalaCards integrated aliases for Pneumothorax:

Name: Pneumothorax 12 73 36 54 6 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:1673
KEGG 36 H01110
SNOMED-CT 67 196103008
ICD10 32 J93 J93.1 J93.9
UMLS 70 C0029850 C0032326

Summaries for Pneumothorax

KEGG : 36 Pneumothorax is defined as air or gas accumulated in the pleural space and can be classified as spontaneous or traumatic. Traumatic pneumothorax includes iatrogenic cases caused during procedures such as pacemaker insertion. Spontaneous pneumothorax can be subclassified as primary or secondary. Primary spontaneous pneumothorax (PSP), which is defined as a pneumothorax without underlying lung disease, predominantly occurs in young, thin males. It is usually caused by ruptured pleural blebs or bullae. Approximately 10% of patients with PSP have a positive family history. Gene mutations in folliculin (FLCN) have been found.

MalaCards based summary : Pneumothorax is related to loeys-dietz syndrome and marfan syndrome, and has symptoms including dyspnea and hemoptysis. An important gene associated with Pneumothorax is FLCN (Folliculin), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Minocycline and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and liver, and related phenotypes are Decreased cell migration and homeostasis/metabolism

Disease Ontology : 12 A pleural disease that is characterized as an abnormal collection of air in the pleural space between the lung and the chest wall.

Wikipedia : 73 A pneumothorax is an abnormal collection of air in the pleural space between the lung and the chest... more...

Related Diseases for Pneumothorax

Diseases related to Pneumothorax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 883)
# Related Disease Score Top Affiliating Genes
1 loeys-dietz syndrome 31.7 FBN1 ELN COL5A1
2 marfan syndrome 31.5 MMP2 MMP1 FBN1 ELN COL5A1
3 pulmonary fibrosis 31.5 TIMP1 MMP9 MMP2 MMP1 ELN
4 lymphangioleiomyomatosis 30.9 TSC1 PGR MMP9 MMP2 MMP1 GNRH1
5 lung disease 30.9 TSC1 SERPINA1 NKX2-1 MUC1 MMP9 ELN
6 interstitial lung disease 30.7 TIMP1 NKX2-1 MUC1 MMP9
7 angiosarcoma 30.7 MUC1 KDR CALB2
8 hemopericardium 30.6 FBN1 ELN
9 pulmonary disease, chronic obstructive 30.6 TIMP1 SERPINA1 MMP9 MMP1 ELN
10 diaphragmatic hernia, congenital 30.6 NKX2-1 FBN1 ELN
11 endometriosis 30.5 TIMP1 PGR MMP2 MMP1 KDR GNRH1
12 alpha-1-antitrypsin deficiency 30.5 SERPINA1 MMP1 ELN
13 orthostatic intolerance 30.5 FBN1 ELN COL5A1
14 malignant pleural mesothelioma 30.4 NKX2-1 MUC1 CALB2
15 aortic aneurysm 30.4 MMP9 MMP2 FBN1 ELN
16 mesothelioma, malignant 30.4 NKX2-1 MUC1 KDR CALB2
17 cryptogenic organizing pneumonia 30.3 TIMP1 MUC1 MMP9
18 pulmonary emphysema 30.2 TIMP2 TIMP1 SERPINA1 MMP9 MMP2 MMP1
19 ehlers-danlos syndrome, vascular type 30.1 FBN1 ELN COL5A1
20 aortic dissection 30.1 MMP9 MMP2 FBN1 ELN COL5A1
21 tuberous sclerosis 1 30.1 TSC1 HIF1A COL5A1
22 adenocarcinoma 30.1 NKX2-1 MUC1 MMP9 MMP2 KDR ALK
23 scoliosis 30.0 TIMP2 MMP9 FBN1 ELN COL5A1
24 thymic carcinoma 30.0 NKX2-1 MUC1 CALB2
25 small cell carcinoma 30.0 NKX2-1 MUC1 ALK
26 angiomyolipoma 29.9 TSC1 PGR FLCN
27 ectopic pregnancy 29.9 PGR MUC1 GNRH1
28 collagen disease 29.9 FBN1 ELN COL5A1
29 asbestosis 29.9 SERPINA1 MUC1 CALB2
30 peritoneal mesothelioma 29.8 PGR MUC1 CALB2 ALK
31 ischemic colitis 29.8 MMP9 MMP2 HIF1A
32 esophageal cancer 29.8 TIMP1 MUC1 MMP9 MMP2 KDR HIF1A
33 hydronephrosis 29.8 TIMP1 MMP9 HIF1A FBN1
34 familial thoracic aortic aneurysm and aortic dissection 29.8 FBN1 ELN COL5A1
35 benign peritoneal mesothelioma 29.8 MUC1 GNRH1 CALB2
36 perivascular epithelioid cell tumor 29.8 PGR NKX2-1 MUC1
37 cutis laxa 29.8 SERPINA1 MMP9 MMP2 FBN1 ELN COL5A1
38 oncocytoma 29.8 NKX2-1 MUC1 FLCN
39 breast ductal carcinoma 29.7 TIMP2 PGR MUC1 MMP9
40 pulmonary fibrosis, idiopathic 29.7 TIMP1 SERPINA1 MUC1 MMP9 MMP2 MMP1
41 polycystic liver disease 1 with or without kidney cysts 29.7 TSC1 MUC1 FLCN FBN1 CALB2
42 lymphangitis 29.7 NKX2-1 ALK
43 leiomyomatosis 29.6 PGR GNRH1 FLCN CALB2
44 pleomorphic carcinoma 29.6 PGR NKX2-1 CALB2 ALK
45 papillary carcinoma 29.6 PGR NKX2-1 MUC1 CALB2
46 lung leiomyosarcoma 29.5 NKX2-1 CALB2
47 lung cancer susceptibility 3 29.5 NKX2-1 MUC1 MMP9 MMP2 KDR HIF1A
48 adenoid cystic carcinoma 29.4 PGR MUC1 MMP9 MMP2 HIF1A
49 tetralogy of fallot 29.4 MMP9 KDR HIF1A FBN1 ELN
50 inguinal hernia 29.4 TIMP2 TIMP1 MMP9 MMP2 MMP1 FBN1

Graphical network of the top 20 diseases related to Pneumothorax:



Diseases related to Pneumothorax

Symptoms & Phenotypes for Pneumothorax

UMLS symptoms related to Pneumothorax:


dyspnea; hemoptysis

GenomeRNAi Phenotypes related to Pneumothorax according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.8 ALK TIMP2 TSC1

MGI Mouse Phenotypes related to Pneumothorax:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 ALK BLVRA FBN1 FLCN GNRH1 HIF1A
2 growth/size/body region MP:0005378 10.22 ALK COL5A1 FBN1 FLCN GNRH1 HIF1A
3 cardiovascular system MP:0005385 10.21 COL5A1 FBN1 FLCN HIF1A KDR MMP2
4 neoplasm MP:0002006 10 ALK FLCN GNRH1 HIF1A MMP1 MMP2
5 integument MP:0010771 9.97 ALK COL5A1 FBN1 GNRH1 HIF1A KDR
6 normal MP:0002873 9.9 ALK CALB2 COL5A1 GNRH1 HIF1A KDR
7 respiratory system MP:0005388 9.61 ALK FBN1 HIF1A KDR MMP2 MMP9
8 skeleton MP:0005390 9.36 ALK FBN1 GNRH1 HIF1A KDR MMP2

Drugs & Therapeutics for Pneumothorax

Drugs for Pneumothorax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3
Cefazolin Approved Phase 2, Phase 3 25953-19-9 33255 656510
4
Clindamycin Approved, Vet_approved Phase 2, Phase 3 18323-44-9 29029
5 Anti-Bacterial Agents Phase 2, Phase 3
6 Anti-Infective Agents Phase 2, Phase 3
7 Narcotics Phase 3
8 Analgesics, Opioid Phase 3
9 Anesthetics, Intravenous Phase 3
10 Anesthetics, General Phase 3
11 Pulmonary Surfactants Phase 3
12 Antibiotics, Antitubercular Phase 2, Phase 3
13 Clindamycin phosphate Phase 2, Phase 3
14 Clindamycin palmitate Phase 2, Phase 3
15 Lactams Phase 2, Phase 3
16 penicillins Phase 2, Phase 3
17 Respiratory System Agents Phase 3
18
Povidone Approved Phase 1, Phase 2 9003-39-8 131751496
19
Povidone-iodine Approved Phase 1, Phase 2 25655-41-8
20
Dimenhydrinate Approved Phase 1, Phase 2 523-87-5 441281
21
Iodine Approved, Investigational Phase 1, Phase 2 7553-56-2 807
22
Cadexomer iodine Experimental Phase 1, Phase 2 94820-09-4
23 insulin Phase 2
24 Insulin, Globin Zinc Phase 2
25 Anti-Infective Agents, Local Phase 1, Phase 2
26
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
27
Tetracycline Approved, Vet_approved Phase 1 60-54-8 5353990
28 Pharmaceutical Solutions Phase 1
29 Trace Elements Phase 1
30 Nutrients Phase 1
31 Plasma Substitutes Phase 1
32 Micronutrients Phase 1
33 Blood Substitutes Phase 1
34
Furosemide Approved, Vet_approved 54-31-9 3440
35
Sevoflurane Approved, Vet_approved 28523-86-6 5206
36
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
37
Rocuronium Approved 119302-91-9, 143558-00-3 441290
38
tannic acid Approved 1401-55-4
39
Dexmedetomidine Approved, Vet_approved 113775-47-6 5311068 68602
40
Nitrous oxide Approved, Vet_approved 10024-97-2 948
41
Ketamine Approved, Vet_approved 6740-88-1 3821
42
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
43
Ropivacaine Approved 84057-95-4 71273 175805
44 Kava Approved, Investigational, Nutraceutical 9000-38-8
45 Vasodilator Agents
46 diuretics
47 Anesthetics
48 Anti-Arrhythmia Agents
49 Sodium Channel Blockers
50 Diuretics, Potassium Sparing

Interventional clinical trials:

(show top 50) (show all 135)
# Name Status NCT ID Phase Drugs
1 Improving Primary Spontaneous Pneumothorax (PSP) Treatment Techniques in VATS Unknown status NCT01463553 Phase 4
2 Early Administration of Surfactant in Spontaneous Breathing (TAKE CARE) Versus InSurE (Intubation, Surfactant, Extubation) : A Pilot Study Unknown status NCT01329432 Phase 4
3 A Prospective Randomized Study of 14-French (14F) Pigtail Catheters Versus 28F Chest Tubes in Patients With Traumatic Pneumothorax: Impact on Tube-Site Pain and Failure Rate Unknown status NCT01537289 Phase 3
4 Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax: A Randomized Trial Unknown status NCT00418392 Phase 3
5 Thoracoscopic Bullectomy With Absorbable Mesh Coverage of the Staple Line Versus Thoracoscopic Bullectomy Only for the Treatment of Primary Spontaneous Pneumothorax: a Single-blind, Parallel-group, Prospective, Randomized Controlled Trial Unknown status NCT01848860 Phase 2, Phase 3
6 Comparison of Pleural Abrasion Plus Minocycline Pleurodesis Versus Apical Pleurectomy After Thoracoscopic Bullectomy for High Recurrent Risk Patients With Primary Spontaneous Pneumothorax: A Prospective Randomized Trial. Unknown status NCT00270751 Phase 2, Phase 3
7 Phase III Study of Additional Minocycline Pleurodesis After Video-Assisted Thoracoscopic Surgery for Primary Spontaneous Pneumothorax Unknown status NCT00154895 Phase 3 intrapleural minocycline instillation
8 Comparison of Chest Tube Drainage Versus Thoracoscopic Surgery for Unsuccessful Aspiration of Primary Spontaneous Pneumothorax: a Prospective Randomized Trial Unknown status NCT00713362 Phase 2, Phase 3
9 Effect of Dissecting of The Inferior Pulmonary Ligament on Postoperative Pulmonary Reexpansion and Recurrence After Operation by Video-assisted Thoracic Surgery in the Treatment of Primary Spontaneous Pneumothorax(PSP) Unknown status NCT02558608 Phase 3
10 Use of a Novel Chest Tube Insertion Device for Urgent Thoracostomy in an Emergency Department Setting Unknown status NCT03734471 Phase 3
11 Efficacy and Safety of Continuous Infusion of Fentanyl for Pain Control in Preterm Newborn on Mechanical Ventilation Completed NCT00571636 Phase 3 Fentanyl;5% glucose solution
12 Phase III Study of Evaluation of the Efficacy of Additional Mechanical Pleurodesis After Thoracoscopic Wedge Resection for the Management of Primary Spontaneous Pneumothorax Completed NCT00615849 Phase 3
13 A Prospective, Randomized, Multi-centered Safety and Efficacy Evaluation of the Bio-Seal Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Completed NCT00562302 Phase 3
14 A Prospective Randomized Multi-Centered Study and Efficacy Evaluation of the Bio-Seal Biopsy Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Procedures Completed NCT00527722 Phase 2, Phase 3
15 KatGuide-trial. KatGuide Method Versus Conventional Method at Insertion of Chest Tube. A Randomized, Parallel Group, Controlled Trial. Completed NCT01522885 Phase 3
16 The Role of Antibiotics in the Reduction of Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax: A Prospective, Double-Blinded Study Completed NCT01127880 Phase 2, Phase 3 Ancef or Clindamycin;Placebo
17 Very Early Surfactant Without Mandatory Ventilation In Premature Infants Treated With Early Continuous Positive Airway Pressure-A Randomized Controlled Trial Completed NCT00563641 Phase 3
18 Effect of Autologous Blood Patch Injection Versus BioSentry Hydrogel Tract Plug in the Reduction of Pneumothorax Risk Following Lung Biopsy Procedures Active, not recruiting NCT02224924 Phase 3
19 Minimally Invasive Esophagectomy in Prone or Left Decubitus Position: A Prospective Randomized Clinical Trial From A Single Institution Unknown status NCT01144325 Phase 2
20 Lung Deflation With Arndt® Blocker During Video-Assisted Thoracoscopy: A Comparison of the Disconnection Technique With a Continuous Bronchial Suction Completed NCT02030795 Phase 2
21 Efficacy, Safety and Re-occurrence of Pneumothorax and Hydro-pneumothorax With Talc and Pyodine Pleurodesis: A Randomized Control Trial Enrolling by invitation NCT04130451 Phase 1, Phase 2 PYODINE AND TALC SLURRY
22 Gelfoam Slurry as an Embolization Agent of the Needle Tract to Prevent Pneumothorax From Percutaneous CT-guided Lung Biopsy: A Randomized Controlled Trial Withdrawn NCT03669003 Phase 2
23 Prevalence of Birt-Hogg-Dubé Syndrome Among Patients With (Hereditary) Spontaneous Pneumothorax Unknown status NCT02916992 Phase 1
24 Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination for Chemical Pleurodesis in Malignant Pleural Effusion Recruiting NCT04039126 Phase 1 CHEMICAL PLEURODESIS WITH POVIDONE-IODINE-TETRACYCLINE COMBINATION;CHEMICAL PLEURODESIS WITH POVIDONE-IODINE ALONE
25 Platelet Rich Plasma in Secondary Spontaneous Pneumothorax Recruiting NCT03830645 Phase 1
26 Assessment of Safety of Air Travel in Patients With Pulmonary Langerhans Cell Histiocytosis Unknown status NCT03052101
27 The Incidence of Pneumothorax After CT-guided Lung Biopsy Performed With and Without Autologous Blood Patching: a Randomized Single-center Prospective Study Unknown status NCT03804957
28 Molecular Pathogenesis of Primary Spontaneous Pneumothorax Unknown status NCT01135004
29 Evaluation of a Novel Point-of-care Percussion Device (PD) for Detection of Pneumothorax in Patients Following Thoracic Surgery Unknown status NCT03272815
30 Endobronchial Ultrasonography With a Guide Sheath Versus Computed Tomography-guided Transthoracic Needle Biopsy in the Diagnosis of Peripheral Pulmonary Lesions Unknown status NCT02740400
31 Are EMS Personnel Prepared to Identify and Decompression of Tension Pneumothorax: A Randomized, Crossover Manikin Trial Unknown status NCT02709122
32 Daily Lung Ultrasound Assisting Weaning From Mechanical Ventilation in Difficult-to-wean Adult Patients - a Randomized Trial. Unknown status NCT01724034
33 Effects of Nonintubated Thoracoscopic Lobectomy on Lung Protection: A Randomized Controlled Trial Unknown status NCT03471884
34 Pre-EDIT: A Randomised, Feasibility Trial of Elastance-Directed Intra-pleural Catheter or Talc Pleurodesis (EDIT) in the Management of Symptomatic Malignant Pleural Effusion Without Obvious Non-expansile Lung Unknown status NCT03319186
35 Prevention of Pneumothorax Following Endoscopic Valve Therapy in Patients With Severe Emphysema Unknown status NCT03034421
36 Primary Spontaneous Pneumothorax and Different Types of Surgical Management Unknown status NCT03804385
37 Changes in Heart Rate Variability in Ventilated Patients Undergoing Tension Pneumothorax for Thoracoscopic Cervical Sympathectomy Unknown status NCT03537417
38 A Multi-site Randomized Controlled Study of Interventional Treatment of Refractory Pneumothorax by Bronchoscope Unknown status NCT02352012
39 Predictive Score of PneumOThorax Secondary to CT-guided Transthoracic Lung Biopsy Made From a Large Retrospective Cohort and Validated on a Prospective Cohort Unknown status NCT03488043
40 PCL (Poly-ε-caprolactone) Mesh Pleurodesis in Thoracoscopic Treatment of Primary Spontaneous Pneumothorax Unknown status NCT03227978 Early Phase 1
41 Intrapleural Minocycline After Manual Aspiration for the Prevention of Primary Spontaneous Pneumothorax. A Phase III Multicenter Prospective Randomized Controlled Trial Unknown status NCT00839553
42 Randomized Controlled Trial on Comparison of Chest Tube Drainage and Needle Aspiration in Treatment of Spontaneous Pneumothorax Unknown status NCT03293199
43 Training Thoracic Ultrasound Skills: a Multicentre, Blinded, Randomized Controlled Trial of Simulation-based Training Versus Training on Healthy Figurants Unknown status NCT03728491
44 A Comparative Study of the Safety and Efficacy of Face Talc Slurry and Iodopovidone for Pleurodesis Unknown status NCT00430664
45 A Randomized, Controlled Trial of the Use of a Dedicated Ballooned Intercostal Tube Unknown status NCT03000504
46 Mechanical Ventilation During Cardiac Surgery, a Randomized Controlled Trial Unknown status NCT02090205
47 Video-guided Percutaneous Tracheostomy (PCT): Evaluating the Safety, Efficacy and Simplicity of a Novel Technique, Compared to Conventional PCT Unknown status NCT01012518
48 Video-guided Percutaneous Tracheostomy (PCT): Evaluating the Safety, Efficacy and Simplicity of a Novel Technique Unknown status NCT01013298
49 Impact of Pneumothorax Duration Before Treatment on the Success of Needle Exsufflation Completed NCT02528734
50 Sonography After Thoracic Surgery - SATS (CT0011) Completed NCT01152463

Search NIH Clinical Center for Pneumothorax

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Talc

Genetic Tests for Pneumothorax

Anatomical Context for Pneumothorax

MalaCards organs/tissues related to Pneumothorax:

40
Lung, Heart, Liver, Breast, Bone, Kidney, Brain

Publications for Pneumothorax

Articles related to Pneumothorax:

(show top 50) (show all 22265)
# Title Authors PMID Year
1
A Japanese family with multiple lung cysts and recurrent pneumothorax: a possibility of Birt-Hogg-Dubé syndrome. 54 61
19687589 2009
2
Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. 61 54
18663353 2008
3
Mutations of the Birt Hogg Dube gene in patients with multiple lung cysts and recurrent pneumothorax. 61 54
17496196 2007
4
Birt-Hogg-Dubé (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability. 54 61
16870330 2007
5
Novel mutations in the BHD gene and absence of loss of heterozygosity in fibrofolliculomas of Birt-Hogg-Dubé patients. 61 54
17124507 2007
6
Birt-Hogg-Dubé gene mutations in human endometrial carcinomas with microsatellite instability. 61 54
16691634 2006
7
Emerging clinical picture of lymphangioleiomyomatosis. 61 54
16055626 2005
8
Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults. 54 61
15805188 2005
9
Management of primary spontaneous pneumothorax: less is more. 61
33341134 2021
10
Management of primary spontaneous pneumothorax: less is more - Authors' reply. 61
33341133 2021
11
Pulmonary emphysema, bullae, and pneumothorax in COVID-19 pneumonia. 61
33552325 2021
12
Spontaneous pneumomediastinum, pneumopericardium, pneumothorax, and subcutaneous emphysema in a patient with COVID-19. 61
33686352 2021
13
Postoperative chest liver herniation after cardiophrenic lymph node resection by a transdiaphragmatic approach following primary cytoreductive surgery for advanced endometrioid ovarian cancer: A case report. 61
33728369 2021
14
Swyer-James-MacLeod syndrome presenting as spontaneous pneumothorax in an adult: Case report and review of literature. 61
33732407 2021
15
Minimizing the need for high dependency unit support in adolescent idiopathic scoliosis surgery. Is enhanced recovery and the multidisciplinary team key? 61
32694433 2021
16
Nonintubated Video-Assisted Thoracoscopic Surgery Using Local Anesthesia for Catamenial Pneumothorax. 61
32971062 2021
17
European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances. 61
33773826 2021
18
The child with a syndrome: considerations for management in the emergency department. 61
33779129 2021
19
Tuberculous bronchopleural fistula. 61
33747520 2021
20
Invasive procedures in patients undergoing treatment with lenvatinib for thyroid cancer. 61
33758662 2021
21
The Impact of a Comprehensive Simulation-Based Training and Certification Program on Resident Central Venous Catheter Complication Rates. 61
32910104 2021
22
Laparoscopic repair of traumatic diaphragmatic hernia with colon incarceration: A case report. 61
32790052 2021
23
Lung ultrasound compared with bedside chest radiography in a paediatric cardiac intensive care unit. 61
33006781 2021
24
Percutaneous transthoracic embolisation for massive haemoptysis secondary to peripheral pulmonary artery pseudoaneurysms. 61
33011878 2021
25
A hybrid, image-based and biomechanics-based registration approach to markerless intraoperative nodule localization during video-assisted thoracoscopic surgery. 61
33588119 2021
26
C-shaped pleura cautery in primary spontaneous pneumothorax patients for pleurodesis. 61
32098935 2021
27
The effect of meteorological variables on spontaneous pneumothorax in two regions with different altitudes. 61
33145619 2021
28
Is conventional management of primary spontaneous pneumothorax appropriate? 61
33180257 2021
29
Delayed recurrent spontaneous pneumothorax in a patient recovering from COVID-19 pneumonia. 61
32867010 2021
30
Chest Tube Drainage in the Age of COVID-19. 61
33263088 2021
31
Pneumothorax in 2019 novel coronavirus pneumonia needs to be recognized. 61
32876897 2021
32
Failure of observation and need for delayed tube thoracostomy in 197 unselected patients with occult pneumothorax: a retrospective study. 61
33796890 2021
33
Factors associated with insufficient nasogastric tube visibility on X-ray: a retrospective analysis. 61
33011836 2021
34
New pneumothorax complicating successful treatment of persistent air leak by endobronchial valves. 61
33732465 2021
35
Incidence of Barotrauma in Patients With COVID-19 Pneumonia During Prolonged Invasive Mechanical Ventilation - A Case-Control Study. 61
32959730 2021
36
"The eye sees only what the mind is prepared to comprehend": Unrecognized incidental findings on intraoperative computed tomography during spine instrumentation surgery. 61
33217672 2021
37
Diverse Treatments for Deep Burn Wounds: A Case Report. 61
33739953 2021
38
Intrathoracic migration of a K-wire after percutaneous fixation of a proximal humerus fracture. 61
33665318 2021
39
Assessment of final-year medical students' performance in diagnosing critical findings on chest X-ray. 61
33398711 2021
40
Electrocardiographic manifestations in a large right-sided pneumothorax. 61
33757495 2021
41
Catamenial pneumothorax with partial liver herniation due to diaphragmatic laceration: a case report and literature review. 61
33731157 2021
42
Uniportal thoracoscopic surgical management using a suture traction for primary pneumothorax. 61
33183063 2021
43
Pleuroparenchymal fibroelastosis in Korean patients: clinico-radiologic-pathologic features and 2-year follow-up. 61
32088939 2021
44
Early use of autologous blood patch pleurodesis in children is successful in resolving persistent air leaks. 61
33189301 2021
45
Finding the bubble: atypical and unusual extrapulmonary air in the chest. 61
33678458 2021
46
Tension Hemopneumothorax in the Setting of Mechanical CPR during Prehospital Cardiac Arrest. 61
32208039 2021
47
Effect of Differences in Thorax Volume and Dimensions on CPR-related Injuries. 61
33775013 2021
48
Prevalence and risk factors of barotrauma in Covid-19 patients admitted to an intensive care unit in Kuwait; a retrospective cohort study. 61
33564462 2021
49
Post COVID-19 large pneumatocele: clinical and pathological perspectives. 61
33764376 2021
50
Clinical outcomes of pleural drainage on pneumothorax and hydrothorax in critically ill patients with COVID-19: A case series with literature review. 61
33310504 2021

Variations for Pneumothorax

ClinVar genetic disease variations for Pneumothorax:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 COL5A1 NM_001278074.1(COL5A1):c.608G>T (p.Gly203Val) SNV Likely pathogenic 523328 rs1554781700 GRCh37: 9:137593133-137593133
GRCh38: 9:134701287-134701287

Expression for Pneumothorax

Search GEO for disease gene expression data for Pneumothorax.

Pathways for Pneumothorax

Pathways related to Pneumothorax according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 TSC1 TIMP2 TIMP1 MUC1 KDR HIF1A
2
Show member pathways
13.29 MMP9 MMP2 MMP1 KDR GNRH1 FBN1
3
Show member pathways
12.96 TIMP2 TIMP1 KDR GNRH1 FBN1 ELN
4
Show member pathways
12.92 TSC1 TIMP2 TIMP1 KDR HIF1A GNRH1
5 12.72 MMP9 MMP2 MMP1 HIF1A ALK
6
Show member pathways
12.29 TIMP2 TIMP1 KDR GNRH1 ALK
7 12.18 MMP9 MMP2 KDR HIF1A
8
Show member pathways
11.93 TIMP2 TIMP1 MMP9 MMP2 MMP1 KDR
9
Show member pathways
11.85 TIMP2 TIMP1 MMP9 MMP2 MMP1
10 11.79 TIMP1 MUC1 MMP9 MMP2 MMP1 HIF1A
11 11.62 MMP9 MMP2 MMP1
12 11.57 MMP9 MMP2 HIF1A
13 11.57 TIMP1 SERPINA1 MMP9 MMP2 ELN
14
Show member pathways
11.53 MMP9 MMP2 MMP1
15 11.5 TIMP2 TIMP1 MMP9 MMP2 MMP1
16 11.38 TIMP2 TIMP1 MMP9 MMP2 KDR HIF1A
17 11.24 MMP9 MMP2 MMP1
18 11.14 TIMP2 MUC1 MMP9 MMP1 ELN
19 11.09 TIMP2 MMP9 KDR HIF1A
20 11.08 TIMP2 TIMP1 MMP9
21 10.94 TIMP2 TIMP1 KDR GNRH1 FBN1 ELN

GO Terms for Pneumothorax

Cellular components related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 TIMP2 TIMP1 SERPINA1 MUC1 MMP9 MMP2
2 extracellular space GO:0005615 9.91 TIMP2 TIMP1 SERPINA1 MUC1 MMP9 MMP2
3 basement membrane GO:0005604 9.5 TIMP1 FBN1 COL5A1
4 collagen-containing extracellular matrix GO:0062023 9.5 TIMP2 SERPINA1 MMP9 MMP2 FBN1 ELN
5 extracellular matrix GO:0031012 9.23 TIMP2 TIMP1 MMP9 MMP2 MMP1 FBN1

Biological processes related to Pneumothorax according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.93 TIMP1 MMP9 KDR HIF1A GNRH1
2 cytokine-mediated signaling pathway GO:0019221 9.73 TIMP1 MUC1 MMP9 MMP2 MMP1 HIF1A
3 cellular protein metabolic process GO:0044267 9.72 TIMP1 SERPINA1 MMP2 MMP1 FBN1
4 hippocampus development GO:0021766 9.7 TSC1 NKX2-1 ALK
5 response to hormone GO:0009725 9.65 TIMP2 TIMP1 NKX2-1
6 collagen catabolic process GO:0030574 9.61 MMP9 MMP2 MMP1
7 negative regulation of TOR signaling GO:0032007 9.58 TSC1 HIF1A FLCN
8 response to amyloid-beta GO:1904645 9.55 MMP9 MMP2
9 extracellular matrix disassembly GO:0022617 9.55 TIMP2 TIMP1 MMP9 MMP2 MMP1
10 positive regulation of macroautophagy GO:0016239 9.54 TSC1 KDR HIF1A
11 negative regulation of metallopeptidase activity GO:1905049 9.51 TIMP2 TIMP1
12 extracellular matrix organization GO:0030198 9.5 MMP9 MMP2 MMP1 KDR FBN1 ELN
13 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.49 TIMP2 TIMP1
14 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.46 TIMP1 HIF1A
15 cellular response to UV-A GO:0071492 8.92 TIMP1 MMP9 MMP2 MMP1

Molecular functions related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.5 MMP9 MMP2 MMP1
2 Hsp90 protein binding GO:0051879 9.33 TSC1 KDR HIF1A
3 extracellular matrix constituent conferring elasticity GO:0030023 9.26 FBN1 ELN
4 integrin binding GO:0005178 9.26 TIMP2 KDR FBN1 COL5A1
5 zinc ion binding GO:0008270 9.17 TIMP2 TIMP1 PGR MMP9 MMP2 MMP1

Sources for Pneumothorax

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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