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MCID: PNM008
MIFTS: 56

Pneumothorax

Categories: Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pneumothorax

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MalaCards integrated aliases for Pneumothorax:

Name: Pneumothorax 12 74 36 54 6 15 71 32

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1673
KEGG 36 H01110
ICD10 32 J93 J93.1 J93.9
UMLS 71 C0029850 C0032326
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Summaries for Pneumothorax

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KEGG : 36 Pneumothorax is defined as air or gas accumulated in the pleural space and can be classified as spontaneous or traumatic. Traumatic pneumothorax includes iatrogenic cases caused during procedures such as pacemaker insertion. Spontaneous pneumothorax can be subclassified as primary or secondary. Primary spontaneous pneumothorax (PSP), which is defined as a pneumothorax without underlying lung disease, predominantly occurs in young, thin males. It is usually caused by ruptured pleural blebs or bullae. Approximately 10% of patients with PSP have a positive family history. Gene mutations in folliculin (FLCN) have been found.

MalaCards based summary : Pneumothorax is related to pulmonary fibrosis and marfan syndrome, and has symptoms including dyspnea and hemoptysis. An important gene associated with Pneumothorax is FLCN (Folliculin), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Ketamine and Nitrous oxide have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and breast, and related phenotypes are Decreased cell migration and homeostasis/metabolism

Disease Ontology : 12 A pleural disease that is characterized as an abnormal collection of air in the pleural space between the lung and the chest wall.

Wikipedia : 74 A pneumothorax is an abnormal collection of air in the pleural space between the lung and the chest... more...

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Related Diseases for Pneumothorax

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Diseases related to Pneumothorax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 824)
# Related Disease Score Top Affiliating Genes
1 pulmonary fibrosis 32.7 TIMP1 MMP9 MMP2 MMP1 ELN
2 marfan syndrome 32.5 TIMP2 MMP2 MMP1 FBN1 ELN COL5A1
3 lymphangioleiomyomatosis 32.1 TSC1 PGR MMP9 MMP2 MMP1 GNRH1
4 lung disease 31.3 TSC1 SERPINA1 NKX2-1 MUC1 MMP9 ELN
5 pulmonary disease, chronic obstructive 31.1 TIMP1 SERPINA1 MMP9 MMP1 ELN
6 interstitial lung disease 31.1 TIMP1 NKX2-1 MUC1 MMP9
7 endometriosis 31.0 TIMP1 PGR MMP2 MMP1 KDR GNRH1
8 angiosarcoma 31.0 MUC1 KDR CALB2
9 malignant pleural mesothelioma 30.8 NKX2-1 MUC1 CALB2
10 alpha-1-antitrypsin deficiency 30.8 SERPINA1 MMP1 ELN
11 cryptogenic organizing pneumonia 30.7 TIMP1 MUC1 MMP9
12 pulmonary emphysema 30.7 TIMP2 TIMP1 SERPINA1 MMP9 MMP2 MMP1
13 orthostatic intolerance 30.6 FBN1 ELN COL5A1
14 tuberous sclerosis 1 30.5 TSC1 HIF1A COL5A1
15 thymic carcinoma 30.4 NKX2-1 MUC1 CALB2
16 small cell carcinoma 30.3 NKX2-1 MUC1 ALK
17 ectopic pregnancy 30.3 PGR MUC1 GNRH1
18 aortic aneurysm 30.3 TIMP2 TIMP1 MMP9 MMP2 FBN1 ELN
19 peritoneal mesothelioma 30.3 PGR MUC1 CALB2 ALK
20 collagen disease 30.2 FBN1 ELN COL5A1
21 ischemic colitis 30.2 MMP9 MMP2 HIF1A
22 asbestosis 30.2 SERPINA1 MUC1 CALB2
23 hydronephrosis 30.2 TIMP1 MMP9 HIF1A FBN1
24 benign peritoneal mesothelioma 30.2 MUC1 GNRH1 CALB2
25 polycystic liver disease 1 with or without kidney cysts 30.2 TSC1 MUC1 FLCN CALB2
26 pulmonary fibrosis, idiopathic 30.2 TIMP1 SERPINA1 MUC1 MMP9 MMP2 MMP1
27 perivascular epithelioid cell tumor 30.2 PGR NKX2-1 MUC1
28 breast ductal carcinoma 30.2 TIMP2 PGR MUC1 MMP9
29 scoliosis 30.1 TIMP2 TIMP1 SERPINA1 MMP9 FBN1 ELN
30 esophageal cancer 30.1 TIMP2 TIMP1 MUC1 MMP9 MMP2 KDR
31 leiomyomatosis 30.1 PGR GNRH1 FLCN CALB2
32 brittle bone disorder 30.1 FBN1 ELN COL5A1
33 oncocytoma 30.1 NKX2-1 MUC1 FLCN
34 pleomorphic carcinoma 30.0 PGR NKX2-1 CALB2 ALK
35 papillary carcinoma 30.0 PGR NKX2-1 MUC1 CALB2
36 adenocarcinoma 30.0 TIMP2 TIMP1 NKX2-1 MUC1 MMP9 MMP2
37 lipoprotein quantitative trait locus 29.9 MMP9 KDR HIF1A ELN
38 inguinal hernia 29.9 TIMP2 TIMP1 MMP9 MMP2 MMP1 FBN1
39 cutis laxa 29.8 SERPINA1 MMP9 MMP2 MMP1 FBN1 ELN
40 myocardial infarction 29.8 TIMP2 TIMP1 MMP9 MMP2 MMP1 KDR
41 adenoid cystic carcinoma 29.8 PGR MUC1 MMP9 MMP2 HIF1A
42 tetralogy of fallot 29.8 MMP9 KDR HIF1A FBN1 ELN
43 fibrosarcoma 29.7 TIMP2 TIMP1 MMP9 MMP2 MMP1 HIF1A
44 kidney cancer 29.7 TSC1 KDR HIF1A FLCN
45 myeloma, multiple 29.6 MUC1 MMP9 MMP2 KDR HIF1A ALK
46 aortic aneurysm, familial abdominal, 1 29.6 TIMP2 TIMP1 MMP9 MMP2 MMP1 FBN1
47 hemangioma 29.6 PGR NKX2-1 MUC1 MMP9 KDR HIF1A
48 lung cancer susceptibility 3 29.5 TIMP2 SERPINA1 NKX2-1 MUC1 MMP9 MMP2
49 aortic aneurysm, familial thoracic 1 29.5 TIMP2 TIMP1 MMP9 MMP2 MMP1 FBN1
50 pelvic organ prolapse 29.5 TIMP1 PGR MMP9 MMP2 MMP1 FBN1

Graphical network of the top 20 diseases related to Pneumothorax:



Diseases related to Pneumothorax
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Symptoms & Phenotypes for Pneumothorax

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UMLS symptoms related to Pneumothorax:


dyspnea, hemoptysis

GenomeRNAi Phenotypes related to Pneumothorax according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.8 ALK TIMP2 TSC1

MGI Mouse Phenotypes related to Pneumothorax:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.33 ALK BLVRA FBN1 FLCN GNRH1 HIF1A
2 cardiovascular system MP:0005385 10.27 COL5A1 FBN1 FLCN HIF1A KDR MMP2
3 growth/size/body region MP:0005378 10.26 ALK COL5A1 FBN1 FLCN GNRH1 HIF1A
4 mortality/aging MP:0010768 10.18 ALK COL5A1 FBN1 FLCN HIF1A KDR
5 immune system MP:0005387 10.17 FBN1 FLCN GNRH1 HIF1A KDR MMP1
6 integument MP:0010771 10.06 ALK COL5A1 FBN1 GNRH1 HIF1A KDR
7 neoplasm MP:0002006 10.06 ALK FLCN GNRH1 HIF1A MMP1 MMP2
8 nervous system MP:0003631 10 ALK CALB2 FBN1 GNRH1 HIF1A KDR
9 normal MP:0002873 9.85 CALB2 COL5A1 GNRH1 HIF1A KDR MMP2
10 respiratory system MP:0005388 9.61 ALK FBN1 HIF1A KDR MMP2 MMP9
11 skeleton MP:0005390 9.36 ALK FBN1 GNRH1 HIF1A KDR MMP2
Sources

Drugs & Therapeutics for Pneumothorax

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Drugs for Pneumothorax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 221)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
2
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
3
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
4
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
5
Budesonide Approved Phase 4 51333-22-3 63006 5281004
6
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
7
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
8
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
9
Ondansetron Approved Phase 4 99614-02-5 4595
10
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
11
Methadone Approved Phase 4 76-99-3 4095
12
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
13
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
14
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
15
Racepinephrine Approved Phase 4 329-65-7 838
16
tannic acid Approved Phase 4 1401-55-4
17
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
18
Remifentanil Approved Phase 4 132875-61-7 60815
19
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
20
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
21 Sodium Channel Blockers Phase 4
22 Diuretics, Potassium Sparing Phase 4
23 Excitatory Amino Acid Antagonists Phase 4
24 Anesthetics, Dissociative Phase 4
25 Anesthetics, Inhalation Phase 4
26 Neurotransmitter Agents Phase 4
27 Anti-Anxiety Agents Phase 4
28 Psychotropic Drugs Phase 4
29 GABA Modulators Phase 4
30 Anti-Asthmatic Agents Phase 4
31 Bronchodilator Agents Phase 4
32 Amoxicillin-Potassium Clavulanate Combination Phase 4
33 beta-Lactamase Inhibitors Phase 4
34 Anesthetics, General Phase 4
35 Pulmonary Surfactants Phase 4
36 Fibrinolytic Agents Phase 4
37 Analgesics Phase 4
38 Respiratory System Agents Phase 4
39 Antitussive Agents Phase 4
40 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
41 Epinephryl borate Phase 4
42 Hypnotics and Sedatives Phase 4
43 Analgesics, Non-Narcotic Phase 4
44 Anesthetics, Intravenous Phase 4
45 Narcotics Phase 4
46 Analgesics, Opioid Phase 4
47 Antipyretics Phase 4
48
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
49
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030 46835353
50
Cefazolin Approved Phase 2, Phase 3 25953-19-9 656510 33255

Interventional clinical trials:

(show top 50) (show all 507)
# Name Status NCT ID Phase Drugs
1 Improving Primary Spontaneous Pneumothorax (PSP) Treatment Techniques in VATS Unknown status NCT01463553 Phase 4
2 Early Administration of Surfactant in Spontaneous Breathing (TAKE CARE) Versus InSurE (Intubation, Surfactant, Extubation) : A Pilot Study Unknown status NCT01329432 Phase 4
3 A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol Unknown status NCT01873521 Phase 4
4 Comparing Heated Humidified High-flow Nasal Cannula Therapy and Nasal Continuous Positive Airway Pressure (nCPAP) Ventilation Methods for the Prevention of Extubation Failure in Preterm Infants Less Than 32 Weeks' Gestational Age: Randomized Clinical Trial Unknown status NCT02887846 Phase 4
5 Randomized Comparative Study Between Single-injection , Intra- Cluster -Injection and Double-injection Ultrasound-guided Supraclavicular Block of Brachial Plexus Unknown status NCT03188939 Phase 4
6 Evaluation of Safety and Performance of the BIP Central Venous Catheter With Anti-infective Coating Completed NCT02811380 Phase 4
7 Comparative Study of Ultrasound-guided Paravertebral Block Versus Intravenous Tramadol for Postoperative Pain Control in Percutaneous Nephrolithotomy Completed NCT02412930 Phase 4 Group Tramadol;Bupivacaine
8 Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter on the Incidence of Auto-Pleurodesis in Patients With Malignant Pleural Effusions Completed NCT00978939 Phase 4
9 Onset Time of Brachial Plexus Anesthesia With the Axillary or Infraclavicular Approach Under Real-Time Ultrasound Guidance: a Randomized Controlled Trial Completed NCT00724035 Phase 4 Midazolam;Ropivacaine;Fentanyl
10 A Randomized Trial to Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates in Developing Countries Completed NCT01403623 Phase 4
11 A Randomised, Double Blind, Placebo Controlled Trial of Doxycycline in Lymphangioleiomyomatosis. Completed NCT00989742 Phase 4 Doxycycline;Placebo
12 Impact of the Serratus Plane Block in Pain and the Use of Opioids in Breast Completed NCT02905149 Phase 4
13 Comparison of Bilateral Thoracic Paravertebral Block to Thoracic Epidural Analgesia for Post Operative Analgesia in Patients Undergoing Abdominal Surgery - A Randomized Open Label Study Completed NCT01735851 Phase 4 Thoracic epidural analgesia
14 Two Different Dosages of Nebulized Steroid Versus Parenteral Steroid in the Management of COPD Exacerbations Completed NCT01865500 Phase 4 Budesonide 4 mg;Budesonide 8 mg;Metil prednisolone
15 Rescue Surfactant for Respiratory Distress Syndrome (RDS) in Newborns: Comparing Efficacy of Delivery Via Laryngeal Mask Airway to Delivery by Endotracheal Intubation Completed NCT01042600 Phase 4
16 Diaphragmatic Resection And Gynecological Ovarian Neoplasm Completed NCT03543462 Phase 4
17 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
18 Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain in Patient Undergoing Diagnostic Gynacological Laproscopy. A Randomized Controlled Trial Completed NCT03241602 Phase 4 Intraperitoneal lidocaine
19 A Parallel, Randomized Multicenter Comparison of Triple Lumen Central Venous Catheters Impregnated With Silver Nanoparticles (AgTive®) Versus Conventional Catheters in Intensive Care Unit Patients Completed NCT00337714 Phase 4
20 Use of Nitrous Oxide for Analgesia During Colonoscopy - A Randomised Trial Completed NCT00318825 Phase 4 Nitrous oxide
21 Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life Completed NCT02258763 Phase 4 Amoxicillin-Potassium Clavulanate Combination;Placebo
22 Combined Platelet Rich Plasma Intra-articular Shoulder Injection and Stellate Ganglion Block. A New Technique for Management of Chronic Post-mastectomy Shoulder Pain Syndrome Completed NCT03586154 Phase 4 ketamine and bupivacaine injection
23 Early Intrapleural TPA Instillation Versus Late Recruiting NCT03167281 Phase 4
24 The Ultrasound-guided Multiple-injection Costotransverse Block for Mastectomy and Primary Reconstructive Surgery. A Double Blind, Randomised, Placebo Controlled Trial. Recruiting NCT04248179 Phase 4 Ropivacaine injection;Saline 0.9%;Sufentanil and PONV prophylaxis
25 Efficacy of Rescue Surfactant Delivery Via Endotracheal Intubation (INSURE Technique) Versus Laryngeal Mask Airway (LMA) for Respiratory Distress Syndrome (RDS) in Preterm Neonates Recruiting NCT02164734 Phase 4 remifentanil
26 Regional Blockade of the Sternum With Liposomal Bupivacaine Prior to Incision Decreases Opioid Use in Patients Undergoing Cardiac Surgery (Sternal Block) Recruiting NCT04333095 Phase 4 Liposomal bupivacaine;Normal Saline Flush, 0.9% Injectable Solution_#1
27 Multicentre Randomised Controlled Trial of Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on Continuous Positive Airways Pressure Active, not recruiting NCT02140580 Phase 4
28 Methadone and Interscalene Block for Shoulder Surgery Active, not recruiting NCT03084588 Phase 4 methadone
29 Study of Analgesic Efficacy of Different Kinds of Nerve Blocks on Otoplastic Surgery Not yet recruiting NCT04192708 Phase 4
30 Preoperative Controlled-Release Oxycodone or Intraoperative Morphine As Transition Opioid After Intravenous Anesthesia For Video-Assisted Thoracic Surgery: a Randomized, Double-blind, Controlled Trial. Terminated NCT00681174 Phase 4 Morphine;oxycodone;Propofol;Remifentanil;Paracetamol;Morphine
31 Pain Management After Total Shoulder Arthroplasty: Continuous Interscalene Block Versus Local Tissue Infiltration With Liposomal Bupivacaine Terminated NCT03219983 Phase 4 Ropivacaine;liposomal bupivacaine
32 Oral Corticosteroids Therapy and Interstitial Fibrosis in Patients With Pneumocystis Jirovecii Pneumonia (PCP) and pO2 of >70 at Presentation. Withdrawn NCT00636935 Phase 4 Antibiotics only;Antibiotics + Corticosteroids;Corticosteroids + antibiotics
33 Ultrasound-guided Thoracic Paravertebral Block Versus Ultrasound-guided Thoracic Erector Spinae Plane Block for Pain Management After Unilateral Total Mastectomy: a Randomized Controlled Trial Withdrawn NCT03490006 Phase 4
34 A Prospective Randomized Study of 14-French (14F) Pigtail Catheters Versus 28F Chest Tubes in Patients With Traumatic Pneumothorax: Impact on Tube-Site Pain and Failure Rate Unknown status NCT01537289 Phase 3
35 Effect of Dissecting of The Inferior Pulmonary Ligament on Postoperative Pulmonary Reexpansion and Recurrence After Operation by Video-assisted Thoracic Surgery in the Treatment of Primary Spontaneous Pneumothorax(PSP) Unknown status NCT02558608 Phase 3
36 Comparison of Chest Tube Drainage Versus Thoracoscopic Surgery for Unsuccessful Aspiration of Primary Spontaneous Pneumothorax: a Prospective Randomized Trial Unknown status NCT00713362 Phase 2, Phase 3
37 Thoracoscopic Bullectomy With Absorbable Mesh Coverage of the Staple Line Versus Thoracoscopic Bullectomy Only for the Treatment of Primary Spontaneous Pneumothorax: a Single-blind, Parallel-group, Prospective, Randomized Controlled Trial Unknown status NCT01848860 Phase 2, Phase 3
38 Comparison of Pleural Abrasion Plus Minocycline Pleurodesis Versus Apical Pleurectomy After Thoracoscopic Bullectomy for High Recurrent Risk Patients With Primary Spontaneous Pneumothorax: A Prospective Randomized Trial. Unknown status NCT00270751 Phase 2, Phase 3
39 Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax: A Randomized Trial Unknown status NCT00418392 Phase 3
40 Phase III Study of Additional Minocycline Pleurodesis After Video-Assisted Thoracoscopic Surgery for Primary Spontaneous Pneumothorax Unknown status NCT00154895 Phase 3 intrapleural minocycline instillation
41 Prospective and Randomized Study Comparing 14 F Pigtail Catheter to Traditional 32-36F Chest Tube in the Management of Traumatic Hemothorax and Hemopneumothorax Unknown status NCT02553434 Phase 3
42 Lymphangioleiomyomatosis Efficacy and Safety Trial Unknown status NCT00414648 Phase 3 Sirolimus;Placebo sirolimus
43 Comparing of Computed Tomography Guided Microcoil Localization and Hook Wire Localization for Pulmonary Small Nodules and Ground-glass Opacity Prior to Thoracoscopic Resection Unknown status NCT02908646 Phase 3
44 Randomised Controlled Trial Comparing the Diagnostic Yield of Radial Endo-Bronchial Ultra-Sound (R-EBUS) Guided Cryo-biopsy Vs. CT-guided Transthoracic Biopsy in Patients With Parenchymal Lung Lesion, Suspected of Lung Cancer (CT-CROP) Unknown status NCT02395939 Phase 3
45 The NoTube Study: Evaluation of the Necessity of a Chest Tube After a Video-assisted Thoracoscopic Surgery Pulmonary Wedge Resection. Unknown status NCT00841750 Phase 3
46 Use of Orotracheal CPAP ( Gregory System) for Treatment of Respiratory Failure in Newborns Unknown status NCT01379820 Phase 2, Phase 3
47 Nasal Intermittent Mandatory Ventilation Versus Continuous Positive Airway Pressure After Extubation of Very Low Birth Weight Infants of the NEOCOSUR Network. Unknown status NCT01778829 Phase 3
48 Intranasal Midazolam Versus Intranasal Ketamine to Sedate Newborns for Intubation in Delivery Room. Unknown status NCT01517828 Phase 3 Sedation by ketamine;Sedation with Midazolam
49 Randomized Comparison of Cyclophosphamide Versus Fludarabine in Addition to Anti-thymocyte Globulin for the Conditioning Therapy in Allogeneic Hematopoietic Cell Transplantation for Adult Acquired Aplastic Anemia Unknown status NCT01145976 Phase 3 Cy-ATG;Flu-ATG
50 A Prospective, Randomized, Multi-centered Safety and Efficacy Evaluation of the Bio-Seal Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Completed NCT00562302 Phase 3

Search NIH Clinical Center for Pneumothorax

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Talc
Sources

Genetic Tests for Pneumothorax

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Anatomical Context for Pneumothorax

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MalaCards organs/tissues related to Pneumothorax:

40
Lung, Heart, Breast, Liver, Testes, Bone, Kidney
Sources

Publications for Pneumothorax

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Articles related to Pneumothorax:

(show top 50) (show all 20998)
# Title Authors PMID Year
1
A Japanese family with multiple lung cysts and recurrent pneumothorax: a possibility of Birt-Hogg-Dubé syndrome. 61 54
19687589 2009
2
Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. 54 61
18663353 2008
3
Mutations of the Birt Hogg Dube gene in patients with multiple lung cysts and recurrent pneumothorax. 61 54
17496196 2007
4
Birt-Hogg-Dubé (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability. 61 54
16870330 2007
5
Novel mutations in the BHD gene and absence of loss of heterozygosity in fibrofolliculomas of Birt-Hogg-Dubé patients. 54 61
17124507 2007
6
Birt-Hogg-Dubé gene mutations in human endometrial carcinomas with microsatellite instability. 61 54
16691634 2006
7
Emerging clinical picture of lymphangioleiomyomatosis. 54 61
16055626 2005
8
Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults. 54 61
15805188 2005
9
Clamping trials prior to thoracostomy tube removal and the need for subsequent invasive pleural drainage. 61
31948700 2020
10
Radiologically Guided Management of Secondary Spontaneous Pneumothorax. 61
32547671 2020
11
Pleuropulmonary Blastoma Misinterpreted as Spontaneous Pneumothorax in an Infant. 61
32305285 2020
12
Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. 61
32174129 2020
13
Intrapleural Impedance Sensor Real-Time Tracking of Pneumothorax in a Porcine Model of Air Leak. 61
31610232 2020
14
Deep learning algorithm for surveillance of pneumothorax after lung biopsy: a multicenter diagnostic cohort study. 61
32162001 2020
15
Vallecular cyst with coexisting laryngomalacia: Successful diagnosis and laser therapy by flexible endoscopy with a novel noninvasive ventilation support in infants. 61
32343051 2020
16
Primary tracheocutaneous fistula closure with immediate transition to nocturnal noninvasive positive pressure ventilation in two children with Congenital Central Hypoventilation Syndrome. 61
32247940 2020
17
Emergency tracheal intubation in 202 patients with COVID-19 in Wuhan, China: lessons learnt and international expert recommendations. 61
32312571 2020
18
Preresection Stained Glue Injection to Localize Pulmonary Small Nodules and Ground-glass Opacities. 61
32032250 2020
19
Focus on the pulmonary involvement and genetic patterns in Birt-Hogg-Dubè syndrome: Literature review. 61
32469710 2020
20
Combined non-intubated anaesthesia and paravertebral nerve block in comparison with intubated anaesthesia in children undergoing video-assisted thoracic surgery. 61
32145713 2020
21
Spontaneous sternal fracture during labor in a healthy primigravida with female athlete triad: A case report. 61
32435601 2020
22
Isolated Left Lower Lobe Pleuroparenchymal Fibroelastosis Presenting as Hemothorax. 61
31926159 2020
23
Complications After Percutaneous Ultrasound-Guided Liver Biopsy: A Systematic Review and Meta-analysis of a Population of More Than 12,000 Patients From 51 Cohort Studies. 61
31999005 2020
24
Pneumothorax Rate and Diagnostic Adequacy of Computed Tomography-guided Lung Nodule Biopsies Performed With 18 G Versus 20 G Needles: A Cross-Sectional Study. 61
32032253 2020
25
The results and outcome of primary spontaneous pneumothorax in adolescents. 61
32549138 2020
26
Bronchoscopic Lung Volume Reduction with Valves and Coils: A Network Meta-analysis. 61
32574516 2020
27
Secondary tension pneumothorax in a COVID-19 pneumonia patient: a case report. 61
32557347 2020
28
CT imaging features of COVID-19 pneumonia: initial experience from Turkey. 61
32558645 2020
29
Imaging features of the initial chest thin-section CT scans from 110 patients after admission with suspected or confirmed diagnosis of COVID-19. 61
32539692 2020
30
The practicality of a two-incision surgical approach for hypoglossal nerve stimulator implantation. 61
32521300 2020
31
Low-Grade Myofibroblastic Sarcoma Arising from Keloid Scar on the Chest Wall after Thoracic Surgery. 61
32505704 2020
32
Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER): A Multicenter Matched Cohort Analysis. 61
32282427 2020
33
Enteral hydration in high-flow therapy for infants with bronchiolitis: Secondary analysis of a randomised trial. 61
32043304 2020
34
A Rare Case of 4 Ps: Bilateral Pneumothoraces and Pneumomediastinum in Pneumocystis Pneumonia. 61
32481782 2020
35
[Unilateral Pulmonary Edema during Aortic Valve Replacement through Median Sternotomy]. 61
32475964 2020
36
Complications following symptom limited thoracentesis using suction. 61
32499336 2020
37
Comparing thoracoabdominal injuries of manual versus load-distributing band cardiopulmonary resuscitation. 61
31714472 2020
38
Subclavian and Axillary Vein Access Versus Cephalic Vein Cutdown for Cardiac Implantable Electronic Device Implantation: A Meta-Analysis. 61
32553216 2020
39
Influence of the Insertion Site on Central Venous Catheter-Related Complications in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation. 61
32084541 2020
40
[Autopneumonectomie. A Forgotten Disease]. 61
32557508 2020
41
Pneumothorax as a Complication of Liposuction. 61
32004368 2020
42
Acupuncture induced pneumothorax: A case report. 61
32577244 2020
43
Commentary on: Pneumothorax as a Complication of Liposuction. 61
32259208 2020
44
Pneumothorax and the biology of Birt-Hogg-Dubé syndrome. 61
32414881 2020
45
Diagnosis of pneumothorax in major trauma: fast or accuracy? 61
32144683 2020
46
A Pregnant Woman Presenting With Progressively Worsening Dyspnea and Pneumothorax. 61
32505325 2020
47
Diagnostic performance of prehospital ultrasound diagnosis for traumatic pneumothorax by a UK Helicopter Emergency Medical Service. 61
31714473 2020
48
[CT-guided Percutaneous Lung Puncture for the Diagnosis of Solid Pulmonary Nodules: A Single-center Experience Summary]. 61
32517442 2020
49
Complications from Needle Thoracostomy: Penetration of the Myocardium. 61
32437217 2020
50
Safety of the anterior approach versus the lateral approach for chest tube insertion by residents treating spontaneous pneumothorax: a propensity score weighted analysis. 61
32519192 2020
Sources

Variations for Pneumothorax

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ClinVar genetic disease variations for Pneumothorax:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 COL5A1 NM_001278074.1(COL5A1):c.608G>T (p.Gly203Val)SNV Likely pathogenic 523328 rs1554781700 9:137593133-137593133 9:134701287-134701287
2 46;XY;t(20;22)(q13.3;q11.2)Translocation Uncertain significance 267893
Sources

Expression for Pneumothorax

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Search GEO for disease gene expression data for Pneumothorax.
Sources

Pathways for Pneumothorax

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Pathways related to Pneumothorax according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.69 TSC1 TIMP2 TIMP1 MUC1 KDR HIF1A
2
Integrin Pathway 63
Show member pathways
 13.29 MMP9 MMP2 MMP1 KDR GNRH1 FBN1
3
Phospholipase-C Pathway 63
Show member pathways
 12.96 TIMP2 TIMP1 KDR GNRH1 FBN1 ELN
4
p70S6K Signaling 63
Show member pathways
 12.92 TSC1 TIMP2 TIMP1 KDR HIF1A GNRH1
5
Pathways in cancer 36
12.72 MMP9 MMP2 MMP1 HIF1A ALK
6
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.29 TIMP2 TIMP1 KDR GNRH1 ALK
7
Proteoglycans in cancer 36
12.18 MMP9 MMP2 KDR HIF1A
8
Degradation of the extracellular matrix 65
Show member pathways
 11.93 TIMP2 TIMP1 MMP9 MMP2 MMP1 KDR
9
Matrix Metalloproteinases 1
Show member pathways
 11.85 TIMP2 TIMP1 MMP9 MMP2 MMP1
10
Interleukin-4 and 13 signaling 65
11.79 TIMP1 MUC1 MMP9 MMP2 MMP1 HIF1A
11
Bladder cancer 36 1
11.62 MMP9 MMP2 MMP1
12
AGE/RAGE pathway 1
11.57 MMP9 MMP2 HIF1A
13
Lung fibrosis 1
11.57 TIMP1 SERPINA1 MMP9 MMP2 ELN
14
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.53 MMP9 MMP2 MMP1
15
Cell adhesion_ECM remodeling 22
11.5 TIMP2 TIMP1 MMP9 MMP2 MMP1
16
Angiogenesis (CST) 4
11.38 TIMP2 TIMP1 MMP9 MMP2 KDR HIF1A
17
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.24 MMP9 MMP2 MMP1
18
Cell adhesion_Cell-matrix glycoconjugates 22
11.14 TIMP2 MUC1 MMP9 MMP1 ELN
19
Angiogenesis (WikiPathways) 1
11.09 TIMP2 MMP9 KDR HIF1A
20
IL1 and megakaryocytes in obesity 1
11.08 TIMP2 TIMP1 MMP9
21
G-protein signaling_Rap2B regulation pathway 22
10.94 TIMP2 TIMP1 KDR GNRH1 FBN1 ELN
Sources

GO Terms for Pneumothorax

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Cellular components related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 TIMP2 TIMP1 SERPINA1 MUC1 MMP9 MMP2
2 extracellular space GO:0005615 9.91 TIMP2 TIMP1 SERPINA1 MUC1 MMP9 MMP2
3 basement membrane GO:0005604 9.5 TIMP1 FBN1 COL5A1
4 collagen-containing extracellular matrix GO:0062023 9.5 TIMP2 SERPINA1 MMP9 MMP2 FBN1 ELN
5 extracellular matrix GO:0031012 9.23 TIMP2 TIMP1 MMP9 MMP2 MMP1 FBN1

Biological processes related to Pneumothorax according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.92 TIMP1 MMP9 KDR HIF1A GNRH1
2 hippocampus development GO:0021766 9.69 TSC1 NKX2-1 ALK
3 cellular protein metabolic process GO:0044267 9.65 TIMP1 SERPINA1 MMP2 MMP1 FBN1
4 response to hormone GO:0009725 9.63 TIMP2 TIMP1 NKX2-1
5 cytokine-mediated signaling pathway GO:0019221 9.63 TIMP1 MUC1 MMP9 MMP2 MMP1 HIF1A
6 collagen catabolic process GO:0030574 9.58 MMP9 MMP2 MMP1
7 response to amyloid-beta GO:1904645 9.54 MMP9 MMP2
8 positive regulation of macroautophagy GO:0016239 9.54 TSC1 KDR HIF1A
9 negative regulation of TOR signaling GO:0032007 9.5 TSC1 HIF1A FLCN
10 negative regulation of metallopeptidase activity GO:1905049 9.49 TIMP2 TIMP1
11 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.48 TIMP2 TIMP1
12 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.43 TIMP1 HIF1A
13 extracellular matrix disassembly GO:0022617 9.35 TIMP2 TIMP1 MMP9 MMP2 MMP1
14 extracellular matrix organization GO:0030198 9.17 MMP9 MMP2 MMP1 KDR FBN1 ELN

Molecular functions related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.5 MMP9 MMP2 MMP1
2 Hsp90 protein binding GO:0051879 9.33 TSC1 KDR HIF1A
3 extracellular matrix constituent conferring elasticity GO:0030023 9.26 FBN1 ELN
4 integrin binding GO:0005178 9.26 TIMP2 KDR FBN1 COL5A1
5 zinc ion binding GO:0008270 9.17 TIMP2 TIMP1 PGR MMP9 MMP2 MMP1
Sources

Sources for Pneumothorax

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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