Aliases & Classifications for Pneumothorax

MalaCards integrated aliases for Pneumothorax:

Name: Pneumothorax 12 74 36 54 6 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:1673
KEGG 36 H01110
SNOMED-CT 67 196103008
ICD10 32 J93 J93.1 J93.9
UMLS 71 C0029850 C0032326

Summaries for Pneumothorax

KEGG : 36 Pneumothorax is defined as air or gas accumulated in the pleural space and can be classified as spontaneous or traumatic. Traumatic pneumothorax includes iatrogenic cases caused during procedures such as pacemaker insertion. Spontaneous pneumothorax can be subclassified as primary or secondary. Primary spontaneous pneumothorax (PSP), which is defined as a pneumothorax without underlying lung disease, predominantly occurs in young, thin males. It is usually caused by ruptured pleural blebs or bullae. Approximately 10% of patients with PSP have a positive family history. Gene mutations in folliculin (FLCN) have been found.

MalaCards based summary : Pneumothorax is related to pulmonary fibrosis and loeys-dietz syndrome, and has symptoms including dyspnea and hemoptysis. An important gene associated with Pneumothorax is FLCN (Folliculin), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Minocycline and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and kidney, and related phenotypes are Decreased cell migration and homeostasis/metabolism

Disease Ontology : 12 A pleural disease that is characterized as an abnormal collection of air in the pleural space between the lung and the chest wall.

Wikipedia : 74 A pneumothorax is an abnormal collection of air in the pleural space between the lung and the chest... more...

Related Diseases for Pneumothorax

Diseases related to Pneumothorax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 878)
# Related Disease Score Top Affiliating Genes
1 pulmonary fibrosis 31.6 TIMP1 MMP9 MMP2 MMP1 ELN
2 loeys-dietz syndrome 31.2 FBN1 ELN COL5A1
3 marfan syndrome 31.1 MMP2 MMP1 FBN1 ELN COL5A1
4 lymphangioleiomyomatosis 31.0 TSC1 PGR MMP9 MMP2 MMP1 GNRH1
5 lung disease 31.0 TSC1 SERPINA1 NKX2-1 MUC1 MMP9 ELN
6 interstitial lung disease 30.8 TIMP1 NKX2-1 MUC1 MMP9
7 angiosarcoma 30.7 MUC1 KDR CALB2
8 pulmonary disease, chronic obstructive 30.7 TIMP1 SERPINA1 MMP9 MMP1 ELN
9 endometriosis 30.7 TIMP1 PGR MMP2 MMP1 KDR GNRH1
10 malignant pleural mesothelioma 30.6 NKX2-1 MUC1 CALB2
11 hemopericardium 30.6 FBN1 ELN
12 diaphragmatic hernia, congenital 30.6 NKX2-1 FBN1 ELN
13 alpha-1-antitrypsin deficiency 30.6 SERPINA1 MMP1 ELN
14 mesothelioma, malignant 30.5 NKX2-1 MUC1 KDR CALB2
15 cryptogenic organizing pneumonia 30.4 TIMP1 MUC1 MMP9
16 pulmonary emphysema 30.4 TIMP2 TIMP1 SERPINA1 MMP9 MMP2 MMP1
17 adenocarcinoma 30.2 NKX2-1 MUC1 MMP9 MMP2 KDR ALK
18 aortic aneurysm 30.2 TIMP1 MMP9 MMP2 FBN1 ELN
19 thymic carcinoma 30.0 NKX2-1 MUC1 CALB2
20 small cell carcinoma 30.0 NKX2-1 MUC1 ALK
21 orthostatic intolerance 30.0 FBN1 ELN COL5A1
22 ectopic pregnancy 30.0 PGR MUC1 GNRH1
23 peritoneal mesothelioma 29.9 PGR MUC1 CALB2 ALK
24 esophageal cancer 29.9 TIMP1 MUC1 MMP9 MMP2 KDR HIF1A
25 pulmonary fibrosis, idiopathic 29.9 TIMP1 SERPINA1 MUC1 MMP9 MMP2 MMP1
26 asbestosis 29.9 SERPINA1 MUC1 CALB2
27 ischemic colitis 29.9 MMP9 MMP2 HIF1A
28 hydronephrosis 29.9 TIMP1 MMP9 HIF1A FBN1
29 benign peritoneal mesothelioma 29.8 MUC1 GNRH1 CALB2
30 perivascular epithelioid cell tumor 29.8 PGR NKX2-1 MUC1
31 breast ductal carcinoma 29.8 TIMP2 PGR MUC1 MMP9
32 oncocytoma 29.8 NKX2-1 MUC1 FLCN
33 pulmonary hypertension 29.8 TIMP1 SERPINA1 MMP9 KDR HIF1A ELN
34 polycystic liver disease 1 with or without kidney cysts 29.7 TSC1 MUC1 FLCN FBN1 CALB2
35 leiomyomatosis 29.7 PGR GNRH1 FLCN CALB2
36 lymphangitis 29.7 NKX2-1 ALK
37 pleomorphic carcinoma 29.7 PGR NKX2-1 CALB2 ALK
38 lung cancer susceptibility 3 29.7 NKX2-1 MUC1 MMP9 MMP2 KDR HIF1A
39 papillary carcinoma 29.7 PGR NKX2-1 MUC1 CALB2
40 hemangioma 29.6 NKX2-1 MMP9 KDR HIF1A
41 tuberous sclerosis 1 29.6 TSC1 HIF1A COL5A1
42 lung leiomyosarcoma 29.6 NKX2-1 CALB2
43 adenoid cystic carcinoma 29.5 PGR MUC1 MMP9 HIF1A
44 aortic dissection 29.5 MMP9 MMP2 FBN1 ELN COL5A1
45 tetralogy of fallot 29.5 MMP9 KDR HIF1A FBN1 ELN
46 scoliosis 29.5 TIMP2 SERPINA1 MMP9 FBN1 ELN COL5A1
47 pelvic organ prolapse 29.4 PGR MMP9 MMP2 MMP1 FBN1 ELN
48 myocardial infarction 29.4 TIMP2 TIMP1 MMP9 MMP2 MMP1 KDR
49 collagen disease 29.4 FBN1 ELN COL5A1
50 dilated cardiomyopathy 29.4 TIMP2 TIMP1 MMP9 MMP2 MMP1 FBN1

Graphical network of the top 20 diseases related to Pneumothorax:



Diseases related to Pneumothorax

Symptoms & Phenotypes for Pneumothorax

UMLS symptoms related to Pneumothorax:


dyspnea, hemoptysis

GenomeRNAi Phenotypes related to Pneumothorax according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.8 ALK TIMP2 TSC1

MGI Mouse Phenotypes related to Pneumothorax:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 ALK BLVRA FBN1 FLCN GNRH1 HIF1A
2 growth/size/body region MP:0005378 10.22 ALK COL5A1 FBN1 FLCN GNRH1 HIF1A
3 cardiovascular system MP:0005385 10.21 COL5A1 FBN1 FLCN HIF1A KDR MMP2
4 neoplasm MP:0002006 10 ALK FLCN GNRH1 HIF1A MMP1 MMP2
5 integument MP:0010771 9.97 ALK COL5A1 FBN1 GNRH1 HIF1A KDR
6 normal MP:0002873 9.9 ALK CALB2 COL5A1 GNRH1 HIF1A KDR
7 respiratory system MP:0005388 9.61 ALK FBN1 HIF1A KDR MMP2 MMP9
8 skeleton MP:0005390 9.36 ALK FBN1 GNRH1 HIF1A KDR MMP2

Drugs & Therapeutics for Pneumothorax

Drugs for Pneumothorax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3
Cefazolin Approved Phase 2, Phase 3 25953-19-9 656510 33255
4
Clindamycin Approved, Vet_approved Phase 2, Phase 3 18323-44-9 29029
5 Narcotics Phase 3
6 Analgesics, Opioid Phase 3
7 Anesthetics, General Phase 3
8 Anesthetics, Intravenous Phase 3
9 Anti-Infective Agents Phase 2, Phase 3
10 Anti-Bacterial Agents Phase 2, Phase 3
11 Pulmonary Surfactants Phase 3
12 Respiratory System Agents Phase 3
13 Antibiotics, Antitubercular Phase 2, Phase 3
14 penicillins Phase 2, Phase 3
15 Clindamycin palmitate Phase 2, Phase 3
16 Clindamycin phosphate Phase 2, Phase 3
17 Lactams Phase 2, Phase 3
18
Dimenhydrinate Approved Phase 1, Phase 2 523-87-5 441281
19
Povidone-iodine Approved Phase 1, Phase 2 25655-41-8
20
Iodine Approved, Investigational Phase 1, Phase 2 7553-56-2 807
21
Povidone Approved Phase 1, Phase 2 9003-39-8 131751496
22
Cadexomer iodine Experimental Phase 1, Phase 2 94820-09-4
23 Insulin, Globin Zinc Phase 2
24 insulin Phase 2
25 Anti-Infective Agents, Local Phase 1, Phase 2
26
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
27
Tetracycline Approved, Vet_approved Phase 1 60-54-8 5353990
28 Pharmaceutical Solutions Phase 1
29 Nutrients Phase 1
30 Trace Elements Phase 1
31 Plasma Substitutes Phase 1
32 Blood Substitutes Phase 1
33 Micronutrients Phase 1
34
Furosemide Approved, Vet_approved 54-31-9 3440
35
Sevoflurane Approved, Vet_approved 28523-86-6 5206
36
Rocuronium Approved 119302-91-9, 143558-00-3 441290
37
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
38
Ketamine Approved, Vet_approved 6740-88-1 3821
39
Dexmedetomidine Approved, Vet_approved 113775-47-6 68602 5311068
40
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
41
Nitrous oxide Approved, Vet_approved 10024-97-2 948
42
tannic acid Approved 1401-55-4
43
Ropivacaine Approved 84057-95-4 71273 175805
44 Kava Approved, Investigational, Nutraceutical 9000-38-8
45 diuretics
46 Vasodilator Agents
47 Anesthetics
48 Neurotransmitter Agents
49 Adrenergic alpha-Agonists
50 Analgesics, Non-Narcotic

Interventional clinical trials:

(show top 50) (show all 133)
# Name Status NCT ID Phase Drugs
1 Improving Primary Spontaneous Pneumothorax (PSP) Treatment Techniques in VATS Unknown status NCT01463553 Phase 4
2 Early Administration of Surfactant in Spontaneous Breathing (TAKE CARE) Versus InSurE (Intubation, Surfactant, Extubation) : A Pilot Study Unknown status NCT01329432 Phase 4
3 A Prospective Randomized Study of 14-French (14F) Pigtail Catheters Versus 28F Chest Tubes in Patients With Traumatic Pneumothorax: Impact on Tube-Site Pain and Failure Rate Unknown status NCT01537289 Phase 3
4 Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax: A Randomized Trial Unknown status NCT00418392 Phase 3
5 Comparison of Pleural Abrasion Plus Minocycline Pleurodesis Versus Apical Pleurectomy After Thoracoscopic Bullectomy for High Recurrent Risk Patients With Primary Spontaneous Pneumothorax: A Prospective Randomized Trial. Unknown status NCT00270751 Phase 2, Phase 3
6 Thoracoscopic Bullectomy With Absorbable Mesh Coverage of the Staple Line Versus Thoracoscopic Bullectomy Only for the Treatment of Primary Spontaneous Pneumothorax: a Single-blind, Parallel-group, Prospective, Randomized Controlled Trial Unknown status NCT01848860 Phase 2, Phase 3
7 Phase III Study of Additional Minocycline Pleurodesis After Video-Assisted Thoracoscopic Surgery for Primary Spontaneous Pneumothorax Unknown status NCT00154895 Phase 3 intrapleural minocycline instillation
8 Effect of Dissecting of The Inferior Pulmonary Ligament on Postoperative Pulmonary Reexpansion and Recurrence After Operation by Video-assisted Thoracic Surgery in the Treatment of Primary Spontaneous Pneumothorax(PSP) Unknown status NCT02558608 Phase 3
9 Comparison of Chest Tube Drainage Versus Thoracoscopic Surgery for Unsuccessful Aspiration of Primary Spontaneous Pneumothorax: a Prospective Randomized Trial Unknown status NCT00713362 Phase 2, Phase 3
10 Use of a Novel Chest Tube Insertion Device for Urgent Thoracostomy in an Emergency Department Setting Unknown status NCT03734471 Phase 3
11 Efficacy and Safety of Continuous Infusion of Fentanyl for Pain Control in Preterm Newborn on Mechanical Ventilation Completed NCT00571636 Phase 3 Fentanyl;5% glucose solution
12 A Prospective, Randomized, Multi-centered Safety and Efficacy Evaluation of the Bio-Seal Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Completed NCT00562302 Phase 3
13 Phase III Study of Evaluation of the Efficacy of Additional Mechanical Pleurodesis After Thoracoscopic Wedge Resection for the Management of Primary Spontaneous Pneumothorax Completed NCT00615849 Phase 3
14 A Prospective Randomized Multi-Centered Study and Efficacy Evaluation of the Bio-Seal Biopsy Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Procedures Completed NCT00527722 Phase 2, Phase 3
15 KatGuide-trial. KatGuide Method Versus Conventional Method at Insertion of Chest Tube. A Randomized, Parallel Group, Controlled Trial. Completed NCT01522885 Phase 3
16 Very Early Surfactant Without Mandatory Ventilation In Premature Infants Treated With Early Continuous Positive Airway Pressure-A Randomized Controlled Trial Completed NCT00563641 Phase 3
17 The Role of Antibiotics in the Reduction of Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax: A Prospective, Double-Blinded Study Completed NCT01127880 Phase 2, Phase 3 Ancef or Clindamycin;Placebo
18 Effect of Autologous Blood Patch Injection Versus BioSentry Hydrogel Tract Plug in the Reduction of Pneumothorax Risk Following Lung Biopsy Procedures Active, not recruiting NCT02224924 Phase 3
19 Minimally Invasive Esophagectomy in Prone or Left Decubitus Position: A Prospective Randomized Clinical Trial From A Single Institution Unknown status NCT01144325 Phase 2
20 Lung Deflation With Arndt® Blocker During Video-Assisted Thoracoscopy: A Comparison of the Disconnection Technique With a Continuous Bronchial Suction Completed NCT02030795 Phase 2
21 Efficacy, Safety and Re-occurrence of Pneumothorax and Hydro-pneumothorax With Talc and Pyodine Pleurodesis: A Randomized Control Trial Enrolling by invitation NCT04130451 Phase 1, Phase 2 PYODINE AND TALC SLURRY
22 Gelfoam Slurry as an Embolization Agent of the Needle Tract to Prevent Pneumothorax From Percutaneous CT-guided Lung Biopsy: A Randomized Controlled Trial Withdrawn NCT03669003 Phase 2
23 Prevalence of Birt-Hogg-Dubé Syndrome Among Patients With (Hereditary) Spontaneous Pneumothorax Unknown status NCT02916992 Phase 1
24 Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination for Chemical Pleurodesis in Malignant Pleural Effusion Recruiting NCT04039126 Phase 1 CHEMICAL PLEURODESIS WITH POVIDONE-IODINE-TETRACYCLINE COMBINATION;CHEMICAL PLEURODESIS WITH POVIDONE-IODINE ALONE
25 Platelet Rich Plasma in Secondary Spontaneous Pneumothorax Recruiting NCT03830645 Phase 1
26 Molecular Pathogenesis of Primary Spontaneous Pneumothorax Unknown status NCT01135004
27 The Incidence of Pneumothorax After CT-guided Lung Biopsy Performed With and Without Autologous Blood Patching: a Randomized Single-center Prospective Study Unknown status NCT03804957
28 Assessment of Safety of Air Travel in Patients With Pulmonary Langerhans Cell Histiocytosis Unknown status NCT03052101
29 Evaluation of a Novel Point-of-care Percussion Device (PD) for Detection of Pneumothorax in Patients Following Thoracic Surgery Unknown status NCT03272815
30 The Effect of Perioperative Lung Ultrasonography on Postoperative Outcomes in Children Undergoing Fast-track Cardiac Surgery Unknown status NCT03527862
31 Pre-EDIT: A Randomised, Feasibility Trial of Elastance-Directed Intra-pleural Catheter or Talc Pleurodesis (EDIT) in the Management of Symptomatic Malignant Pleural Effusion Without Obvious Non-expansile Lung Unknown status NCT03319186
32 Daily Lung Ultrasound Assisting Weaning From Mechanical Ventilation in Difficult-to-wean Adult Patients - a Randomized Trial. Unknown status NCT01724034
33 Endobronchial Ultrasonography With a Guide Sheath Versus Computed Tomography-guided Transthoracic Needle Biopsy in the Diagnosis of Peripheral Pulmonary Lesions Unknown status NCT02740400
34 Are EMS Personnel Prepared to Identify and Decompression of Tension Pneumothorax: A Randomized, Crossover Manikin Trial Unknown status NCT02709122
35 Effects of Nonintubated Thoracoscopic Lobectomy on Lung Protection: A Randomized Controlled Trial Unknown status NCT03471884
36 Randomized Controlled Trial on Comparison of Chest Tube Drainage and Needle Aspiration in Treatment of Spontaneous Pneumothorax Unknown status NCT03293199
37 Primary Spontaneous Pneumothorax and Different Types of Surgical Management Unknown status NCT03804385
38 Predictive Score of PneumOThorax Secondary to CT-guided Transthoracic Lung Biopsy Made From a Large Retrospective Cohort and Validated on a Prospective Cohort Unknown status NCT03488043
39 Changes in Heart Rate Variability in Ventilated Patients Undergoing Tension Pneumothorax for Thoracoscopic Cervical Sympathectomy Unknown status NCT03537417
40 A Multi-site Randomized Controlled Study of Interventional Treatment of Refractory Pneumothorax by Bronchoscope Unknown status NCT02352012
41 Intrapleural Minocycline After Manual Aspiration for the Prevention of Primary Spontaneous Pneumothorax. A Phase III Multicenter Prospective Randomized Controlled Trial Unknown status NCT00839553
42 Prevention of Pneumothorax Following Endoscopic Valve Therapy in Patients With Severe Emphysema Unknown status NCT03034421
43 PCL (Poly-ε-caprolactone) Mesh Pleurodesis in Thoracoscopic Treatment of Primary Spontaneous Pneumothorax Unknown status NCT03227978 Early Phase 1
44 A Comparative Study of the Safety and Efficacy of Face Talc Slurry and Iodopovidone for Pleurodesis Unknown status NCT00430664
45 Video-guided Percutaneous Tracheostomy (PCT): Evaluating the Safety, Efficacy and Simplicity of a Novel Technique Unknown status NCT01013298
46 Video-guided Percutaneous Tracheostomy (PCT): Evaluating the Safety, Efficacy and Simplicity of a Novel Technique, Compared to Conventional PCT Unknown status NCT01012518
47 Mechanical Ventilation During Cardiac Surgery, a Randomized Controlled Trial Unknown status NCT02090205
48 A Randomized, Controlled Trial of the Use of a Dedicated Ballooned Intercostal Tube Unknown status NCT03000504
49 Digital Air Leak Monitoring for Patients Undergoing Lung Resection: A Randomized Controlled Clinical Trial Completed NCT01810172
50 Sonography After Thoracic Surgery - SATS (CT0011) Completed NCT01152463

Search NIH Clinical Center for Pneumothorax

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Talc

Genetic Tests for Pneumothorax

Anatomical Context for Pneumothorax

MalaCards organs/tissues related to Pneumothorax:

40
Lung, Breast, Kidney, Brain, Skin, Heart, Thyroid

Publications for Pneumothorax

Articles related to Pneumothorax:

(show top 50) (show all 22034)
# Title Authors PMID Year
1
A Japanese family with multiple lung cysts and recurrent pneumothorax: a possibility of Birt-Hogg-Dubé syndrome. 61 54
19687589 2009
2
Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. 61 54
18663353 2008
3
Mutations of the Birt Hogg Dube gene in patients with multiple lung cysts and recurrent pneumothorax. 61 54
17496196 2007
4
Birt-Hogg-Dubé (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability. 54 61
16870330 2007
5
Novel mutations in the BHD gene and absence of loss of heterozygosity in fibrofolliculomas of Birt-Hogg-Dubé patients. 61 54
17124507 2007
6
Birt-Hogg-Dubé gene mutations in human endometrial carcinomas with microsatellite instability. 61 54
16691634 2006
7
Emerging clinical picture of lymphangioleiomyomatosis. 54 61
16055626 2005
8
Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults. 61 54
15805188 2005
9
Management of primary spontaneous pneumothorax: less is more - Authors' reply. 61
33341133 2021
10
Management of primary spontaneous pneumothorax: less is more. 61
33341134 2021
11
"The eye sees only what the mind is prepared to comprehend": Unrecognized incidental findings on intraoperative computed tomography during spine instrumentation surgery. 61
33217672 2021
12
Pediatric tracheal injuries: Report on 5 cases with special view on the role of bronchoscopy and management. 61
32067775 2021
13
Sudden death due to tension pneumothorax associated with pulmonary tuberculosis. 61
32974890 2021
14
Efficacy of erector spinae plane block for analgesia in breast surgery: a systematic review and meta-analysis. 61
32609389 2021
15
Long-term IV access in paediatrics - why, what, where, who and how. 61
33147351 2021
16
Idiopathic pleuroparenchymal fibroelastosis presenting in recurrent pneumothorax and bilateral pleural effusion: A case report. 61
33277197 2021
17
Dramatic complication of pneumothorax treatment requiring lifesaving open-heart surgery. 61
33363691 2021
18
Choosing Sides: Contralateral Tension Pneumothorax after Thoracotomy. 61
32709386 2021
19
Lung Ultrasound, a Better Choice for Neonatal Pneumothorax: A Systematic Review and Meta-analysis. 61
33341304 2021
20
Rarely fatal bilateral re-expansion pulmonary edema after inserting a chest tube for unilateral spontaneous pneumothorax: a case report. 61
33170459 2021
21
Spindle cell sarcoma: a rare cause of a spontaneous pneumothorax. 61
33532073 2021
22
Spontaneous pneumothorax during nintedanib therapy in patients with systemic sclerosis-associated interstitial lung disease. 61
33552523 2021
23
The reverse halo sign and spontaneous pneumothorax due to pulmonary mucormycosis. 61
33532075 2021
24
Spontaneous pneumothorax and pneumomediastinum as a rare complication of COVID-19 pneumonia: Report of 6 cases. 61
33437348 2021
25
Pediatric Spontaneous Pneumothorax: Does Initial Treatment Affect Outcomes? 61
33189361 2021
26
Survival Benefit of Radiofrequency Ablation with Intratumoral Cisplatin Administration in a Rabbit VX2 Lung Tumor Model. 61
33165680 2021
27
Prevalence and risk factors of barotrauma in Covid-19 patients admitted to an intensive care unit in Kuwait; a retrospective cohort study. 61
33564462 2021
28
Contemporary management strategies of blunt tracheobronchial injuries. 61
32674886 2021
29
[Pneumothorax]. 61
33588508 2021
30
Pneumothorax due to a non-traumatic thoracic wall rupture due to steroid induced muscle wasting. 61
33592182 2021
31
Meta-analysis of the association between emphysematous change on thoracic computerised tomography scan and recurrent pneumothorax. 61
33538832 2021
32
Pneumothorax during lenvatinib treatment for hepatocellular carcinoma with lung metastasis. 61
33108567 2021
33
Two cases of intraoperative hemodynamic instability during combined thoracoscopic-laparoscopic surgery for esophagogastric junction carcinoma. 61
33566182 2021
34
Tension gastrothorax in late-onset congenital diaphragmatic hernia, a rare but life-threatening condition: A case report. 61
33607846 2021
35
Diagnostic Accuracy of CT-Guided Core Needle Biopsy for Thin-Walled Cavitary Pulmonary Lesions. 61
33295816 2021
36
Current management of moderate to severe traumatic pneumothoraces: a survey of emergency clinicians. 61
33574026 2021
37
Electromagnetic navigation bronchoscopic localization versus percutaneous CT-guided localization for thoracoscopic resection of small pulmonary nodules. 61
33398925 2021
38
A novel optical technology based on 690 nm and 850 nm wavelengths to assist needle thoracostomy. 61
33594120 2021
39
The accuracy of cone-beam computed tomography and augmented fluoroscopy-guided bronchoscopic marking of multiple small-sized pulmonary nodules in a hybrid operating room: a retrospective cohort study. 61
33532272 2021
40
Pediatric trauma telemedicine in a rural state: Lessons learned from a 1-year experience. 61
33228973 2021
41
Real-world experience of lenvatinib in patients with advanced anaplastic thyroid cancer. 61
32729092 2021
42
Fluoroscopy X-Ray Organ-Specific Dosimetry System (FLUXOR) for Estimation of Organ Doses and Their Uncertainties in the Canadian Fluoroscopy Cohort Study. 61
33544842 2021
43
The effect of immediate postoperative Boussignac CPAP on adverse pulmonary events after thoracic surgery: A multicentre, randomised controlled trial. 61
33186306 2021
44
Robotic Bronchoscopy for Peripheral Pulmonary Lesions: A Multicenter Pilot and Feasibility Study (BENEFIT). 61
32822675 2021
45
Suspecting a fatal condition on a plain chest radiograph; Boerhaave syndrome. 61
32981463 2021
46
Ultrasound guided axillary vein access: An alternative approach to venous access for cardiac device implantation. 61
33337570 2021
47
Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial. 61
32687801 2021
48
Feasibility and safety of fine positioning needle-mediated breathing control in CT-guided percutaneous puncture of small lung/liver nodules adjacent to diaphragm. 61
33564042 2021
49
Efficacy of hyperthermia pleurodesis: A comparative experimental study on serous membrane of abdominopelvic and thoracic cavities of rats. 61
33608111 2021
50
Implementation of an academic hospital medicine procedure service: 5-year experience. 61
33577741 2021

Variations for Pneumothorax

ClinVar genetic disease variations for Pneumothorax:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 COL5A1 NM_001278074.1(COL5A1):c.608G>T (p.Gly203Val) SNV Likely pathogenic 523328 rs1554781700 9:137593133-137593133 9:134701287-134701287

Expression for Pneumothorax

Search GEO for disease gene expression data for Pneumothorax.

Pathways for Pneumothorax

Pathways related to Pneumothorax according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 TSC1 TIMP2 TIMP1 MUC1 KDR HIF1A
2
Show member pathways
13.29 MMP9 MMP2 MMP1 KDR GNRH1 FBN1
3
Show member pathways
12.96 TIMP2 TIMP1 KDR GNRH1 FBN1 ELN
4
Show member pathways
12.92 TSC1 TIMP2 TIMP1 KDR HIF1A GNRH1
5 12.72 MMP9 MMP2 MMP1 HIF1A ALK
6
Show member pathways
12.29 TIMP2 TIMP1 KDR GNRH1 ALK
7 12.18 MMP9 MMP2 KDR HIF1A
8
Show member pathways
11.93 TIMP2 TIMP1 MMP9 MMP2 MMP1 KDR
9
Show member pathways
11.85 TIMP2 TIMP1 MMP9 MMP2 MMP1
10 11.79 TIMP1 MUC1 MMP9 MMP2 MMP1 HIF1A
11 11.62 MMP9 MMP2 MMP1
12 11.57 MMP9 MMP2 HIF1A
13 11.57 TIMP1 SERPINA1 MMP9 MMP2 ELN
14
Show member pathways
11.53 MMP9 MMP2 MMP1
15 11.5 TIMP2 TIMP1 MMP9 MMP2 MMP1
16 11.38 TIMP2 TIMP1 MMP9 MMP2 KDR HIF1A
17 11.24 MMP9 MMP2 MMP1
18 11.14 TIMP2 MUC1 MMP9 MMP1 ELN
19 11.09 TIMP2 MMP9 KDR HIF1A
20 11.08 TIMP2 TIMP1 MMP9
21 10.94 TIMP2 TIMP1 KDR GNRH1 FBN1 ELN

GO Terms for Pneumothorax

Cellular components related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 TIMP2 TIMP1 SERPINA1 MUC1 MMP9 MMP2
2 extracellular space GO:0005615 9.91 TIMP2 TIMP1 SERPINA1 MUC1 MMP9 MMP2
3 basement membrane GO:0005604 9.5 TIMP1 FBN1 COL5A1
4 collagen-containing extracellular matrix GO:0062023 9.5 TIMP2 SERPINA1 MMP9 MMP2 FBN1 ELN
5 extracellular matrix GO:0031012 9.23 TIMP2 TIMP1 MMP9 MMP2 MMP1 FBN1

Biological processes related to Pneumothorax according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.93 TIMP1 MMP9 KDR HIF1A GNRH1
2 cytokine-mediated signaling pathway GO:0019221 9.73 TIMP1 MUC1 MMP9 MMP2 MMP1 HIF1A
3 cellular protein metabolic process GO:0044267 9.72 TIMP1 SERPINA1 MMP2 MMP1 FBN1
4 hippocampus development GO:0021766 9.7 TSC1 NKX2-1 ALK
5 response to hormone GO:0009725 9.65 TIMP2 TIMP1 NKX2-1
6 collagen catabolic process GO:0030574 9.61 MMP9 MMP2 MMP1
7 negative regulation of TOR signaling GO:0032007 9.58 TSC1 HIF1A FLCN
8 response to amyloid-beta GO:1904645 9.55 MMP9 MMP2
9 extracellular matrix disassembly GO:0022617 9.55 TIMP2 TIMP1 MMP9 MMP2 MMP1
10 positive regulation of macroautophagy GO:0016239 9.54 TSC1 KDR HIF1A
11 negative regulation of metallopeptidase activity GO:1905049 9.51 TIMP2 TIMP1
12 extracellular matrix organization GO:0030198 9.5 MMP9 MMP2 MMP1 KDR FBN1 ELN
13 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.49 TIMP2 TIMP1
14 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.46 TIMP1 HIF1A
15 cellular response to UV-A GO:0071492 8.92 TIMP1 MMP9 MMP2 MMP1

Molecular functions related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.5 MMP9 MMP2 MMP1
2 Hsp90 protein binding GO:0051879 9.33 TSC1 KDR HIF1A
3 extracellular matrix constituent conferring elasticity GO:0030023 9.26 FBN1 ELN
4 integrin binding GO:0005178 9.26 TIMP2 KDR FBN1 COL5A1
5 zinc ion binding GO:0008270 9.17 TIMP2 TIMP1 PGR MMP9 MMP2 MMP1

Sources for Pneumothorax

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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