Aliases & Classifications for Pneumothorax

MalaCards integrated aliases for Pneumothorax:

Name: Pneumothorax 12 75 37 55 6 44 15 72 33


External Ids:

Disease Ontology 12 DOID:1673
KEGG 37 H01110
MeSH 44 D011030
ICD10 33 J93 J93.1 J93.9
UMLS 72 C0029850 C0032326

Summaries for Pneumothorax

KEGG : 37
Pneumothorax is defined as air or gas accumulated in the pleural space and can be classified as spontaneous or traumatic. Traumatic pneumothorax includes iatrogenic cases caused during procedures such as pacemaker insertion. Spontaneous pneumothorax can be subclassified as primary or secondary. Primary spontaneous pneumothorax (PSP), which is defined as a pneumothorax without underlying lung disease, predominantly occurs in young, thin males. It is usually caused by ruptured pleural blebs or bullae. Approximately 10% of patients with PSP have a positive family history. Gene mutations in folliculin (FLCN) have been found.

MalaCards based summary : Pneumothorax is related to pneumothorax, primary spontaneous and marfan syndrome, and has symptoms including dyspnea and hemoptysis. An important gene associated with Pneumothorax is FLCN (Folliculin), and among its related pathways/superpathways are Glioma and Degradation of the extracellular matrix. The drugs Ketamine and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and breast, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 75 A pneumothorax is an abnormal collection of air in the pleural space between the lung and the chest... more...

Related Diseases for Pneumothorax

Diseases related to Pneumothorax via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 744)
# Related Disease Score Top Affiliating Genes
1 pneumothorax, primary spontaneous 34.5 FNIP1 FLCN BLVRA
2 marfan syndrome 32.8 MMP2 FBN1 ELN
3 birt-hogg-dube syndrome 32.2 FNIP2 FNIP1 FLCN
4 lymphangioleiomyomatosis 32.1 TSC1 PGR MMP2 ELN
5 pulmonary emphysema 31.2 SERPINA1 MMP9 ELN
6 pleural disease 31.2 SLC22A4 FNIP2 FNIP1 FLCN
7 lung disease 31.0 TSC1 SERPINA1 MMP9 ELN
8 pulmonary disease, chronic obstructive 30.9 SERPINA1 MMP9 ELN
9 cryptogenic organizing pneumonia 30.2 MUC1 MMP9
10 inguinal hernia 30.2 MMP9 MMP2 FBN1 ELN
11 aortic aneurysm, familial thoracic 1 30.2 MMP2 FBN1 ELN
12 ischemic colitis 30.2 MMP9 MMP2
13 connective tissue disease 30.1 MUC1 FBN1 ELN COL5A1
14 varicose veins 29.9 MMP9 MMP2 ELN
15 aortic aneurysm, familial abdominal, 1 29.8 MMP9 MMP2 FBN1 ELN
16 tracheal stenosis 29.8 SLC22A4 FBN1
17 polycystic liver disease 1 with or without kidney cysts 29.8 TSC1 MUC1 FLCN
18 perivascular epithelioid cell tumor 29.3 PGR MUC1
19 kidney angiomyolipoma 29.2 TSC1 FNIP1 FLCN
20 lung cancer susceptibility 3 29.1 NFE2L2 MUC1 MMP9 MMP2 KDR ALK
21 renal cell carcinoma, nonpapillary 28.9 TSC1 MUC1 MMP9 MMP2 KDR FLCN
22 catamenial pneumothorax 12.7
23 tuberculous pneumothorax 12.6
24 spontaneous tension pneumothorax 12.6
25 pulmonary bullae causing pneumothorax 12.2
26 hemopneumothorax 11.7
27 dicer1-related disorders 11.5
28 hereditary multiple osteochondromas 11.5
29 loeys-dietz syndrome 11.5
30 virus-associated trichodysplasia spinulosa 10.9
31 pulmonary tuberculosis 10.8
32 endometriosis 10.7
33 extracranial arteriovenous malformation 10.7 MMP9 MMP2
34 focal myositis 10.7 MMP9 MMP2
35 villous adenocarcinoma 10.7 MMP9 MMP2
36 lentigo maligna melanoma 10.6 MMP9 MMP2
37 spastic entropion 10.6 MMP9 MMP2
38 respiratory failure 10.6
39 pleural empyema 10.6
40 psammomatous meningioma 10.6 MMP9 MMP2
41 acute transverse myelitis 10.6 MMP9 MMP2
42 late-onset focal dermal elastosis 10.6 FBN1 ELN
43 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.6 FBN1 ELN
44 pulmonary edema 10.6
45 pneumonia 10.5
46 familial abdominal aortic aneurysm 10.5 FBN1 ELN
47 hydrops, lactic acidosis, and sideroblastic anemia 10.5
48 ehlers-danlos syndrome, vascular type 10.5 ELN COL5A1
49 cerebral aneurysms 10.5 MMP2 ELN
50 light chain deposition disease 10.5 MMP9 MMP2

Graphical network of the top 20 diseases related to Pneumothorax:

Diseases related to Pneumothorax

Symptoms & Phenotypes for Pneumothorax

UMLS symptoms related to Pneumothorax:

dyspnea, hemoptysis

MGI Mouse Phenotypes related to Pneumothorax:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ALK BLVRA FBN1 FLCN FNIP1 FNIP2
2 cardiovascular system MP:0005385 10.19 COL5A1 FBN1 FLCN FNIP1 KDR MMP2
3 cellular MP:0005384 10.18 BLVRA FBN1 FLCN FNIP1 FNIP2 KDR
4 mortality/aging MP:0010768 10.18 ALK COL5A1 FBN1 FLCN FNIP1 FNIP2
5 integument MP:0010771 10.01 ALK COL5A1 FBN1 KDR MMP9 NFE2L2
6 embryo MP:0005380 10 COL5A1 FBN1 FLCN KDR NFE2L2 PGR
7 neoplasm MP:0002006 9.91 ALK FLCN FNIP1 FNIP2 MMP2 MMP9
8 muscle MP:0005369 9.87 FBN1 FNIP1 KDR MMP2 MMP9 PGR
9 renal/urinary system MP:0005367 9.7 FBN1 FLCN FNIP1 FNIP2 MMP9 NFE2L2
10 respiratory system MP:0005388 9.5 ALK FBN1 KDR MMP2 MMP9 NFE2L2
11 skeleton MP:0005390 9.23 ALK FBN1 KDR MMP2 MMP9 NFE2L2

Drugs & Therapeutics for Pneumothorax

Drugs for Pneumothorax (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 236)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
Budesonide Approved Phase 4 51333-22-3 63006 5281004
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Methadone Approved, Illicit Phase 4 76-99-3 4095
tannic acid Approved Phase 4 1401-55-4
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Remifentanil Approved Phase 4 132875-61-7 60815
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
21 Sodium Channel Blockers Phase 4
22 Diuretics, Potassium Sparing Phase 4
23 Anesthetics, Intravenous Phase 4
24 Neurotransmitter Agents Phase 4
25 Analgesics, Non-Narcotic Phase 4
26 Excitatory Amino Acid Antagonists Phase 4
27 Anesthetics, General Phase 4
28 Anesthetics, Dissociative Phase 4
29 Anesthetics, Inhalation Phase 4
30 Excitatory Amino Acids Phase 4
31 Adjuvants, Anesthesia Phase 4
32 Cholinergic Agents Phase 4
33 Mydriatics Phase 4
34 Anti-Asthmatic Agents Phase 4
35 Bronchodilator Agents Phase 4
36 Tranquilizing Agents Phase 4
37 Anti-Anxiety Agents Phase 4
38 GABA Agents Phase 4
39 GABA Modulators Phase 4
40 Psychotropic Drugs Phase 4
41 Protective Agents Phase 4
42 Neuroprotective Agents Phase 4
43 Prednisolone acetate Phase 4
44 Methylprednisolone Acetate Phase 4
45 Parasympatholytics Phase 4
46 Muscarinic Antagonists Phase 4
47 Cholinergic Antagonists Phase 4
48 Amoxicillin-Potassium Clavulanate Combination Phase 4
49 beta-Lactamase Inhibitors Phase 4
50 Analgesics Phase 4

Interventional clinical trials:

(show top 50) (show all 447)
# Name Status NCT ID Phase Drugs
1 Improving Primary Spontaneous Pneumothorax (PSP) Treatment Techniques in VATS Unknown status NCT01463553 Phase 4
2 Early Administration of Surfactant in Spontaneous Breathing (TAKE CARE) Versus InSurE (Intubation, Surfactant, Extubation) : A Pilot Study Unknown status NCT01329432 Phase 4
3 A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol Unknown status NCT01873521 Phase 4
4 Comparing Heated Humidified High-flow Nasal Cannula Therapy and Nasal Continuous Positive Airway Pressure (nCPAP) Ventilation Methods for the Prevention of Extubation Failure in Preterm Infants Less Than 32 Weeks' Gestational Age: Randomized Clinical Trial Unknown status NCT02887846 Phase 4
5 Randomized Comparative Study Between Single-injection , Intra- Cluster -Injection and Double-injection Ultrasound-guided Supraclavicular Block of Brachial Plexus Unknown status NCT03188939 Phase 4
6 Evaluation of Safety and Performance of the BIP Central Venous Catheter With Anti-infective Coating Completed NCT02811380 Phase 4
7 A Randomized Trial to Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates in Developing Countries Completed NCT01403623 Phase 4
8 Comparative Study of Ultrasound-guided Paravertebral Block Versus Intravenous Tramadol for Postoperative Pain Control in Percutaneous Nephrolithotomy Completed NCT02412930 Phase 4 Group Tramadol;Bupivacaine
9 Onset Time of Brachial Plexus Anesthesia With the Axillary or Infraclavicular Approach Under Real-Time Ultrasound Guidance: a Randomized Controlled Trial Completed NCT00724035 Phase 4 Midazolam;Ropivacaine;Fentanyl
10 Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter on the Incidence of Auto-Pleurodesis in Patients With Malignant Pleural Effusions Completed NCT00978939 Phase 4
11 A Randomised, Double Blind, Placebo Controlled Trial of Doxycycline in Lymphangioleiomyomatosis. Completed NCT00989742 Phase 4 Doxycycline;Placebo
12 Impact of the Serratus Plane Block in Pain and the Use of Opioids in Breast Completed NCT02905149 Phase 4
13 Comparison of Bilateral Thoracic Paravertebral Block to Thoracic Epidural Analgesia for Post Operative Analgesia in Patients Undergoing Abdominal Surgery - A Randomized Open Label Study Completed NCT01735851 Phase 4 Thoracic epidural analgesia
14 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
15 Two Different Dosages of Nebulized Steroid Versus Parenteral Steroid in the Management of COPD Exacerbations Completed NCT01865500 Phase 4 Budesonide 4 mg;Budesonide 8 mg;Metil prednisolone
16 Rescue Surfactant for Respiratory Distress Syndrome (RDS) in Newborns: Comparing Efficacy of Delivery Via Laryngeal Mask Airway to Delivery by Endotracheal Intubation Completed NCT01042600 Phase 4
17 Multimodal Analgesic Technique for Control of Post-laproscopy Abdominal Pain in Patient Undergoing Diagnostic Gynacological Laproscopy. A Randomized Controlled Trial Completed NCT03241602 Phase 4 Intraperitoneal lidocaine
18 Use of Nitrous Oxide for Analgesia During Colonoscopy - A Randomised Trial Completed NCT00318825 Phase 4 Nitrous oxide
19 A Parallel, Randomized Multicenter Comparison of Triple Lumen Central Venous Catheters Impregnated With Silver Nanoparticles (AgTive®) Versus Conventional Catheters in Intensive Care Unit Patients Completed NCT00337714 Phase 4
20 Combined Platelet Rich Plasma Intra-articular Shoulder Injection and Stellate Ganglion Block. A New Technique for Management of Chronic Post-mastectomy Shoulder Pain Syndrome Completed NCT03586154 Phase 4 ketamine and bupivacaine injection
21 Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life Completed NCT02258763 Phase 4 Amoxicillin-Potassium Clavulanate Combination;Placebo
22 Use of a Novel Chest Tube Insertion Device for Urgent Thoracostomy in an Emergency Department Setting Recruiting NCT03769727 Phase 4
23 Early Intrapleural TPA Instillation Versus Late Recruiting NCT03167281 Phase 4
24 Multicentre Randomised Controlled Trial of Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on Continuous Positive Airways Pressure Recruiting NCT02140580 Phase 4
25 Efficacy of Rescue Surfactant Delivery Via Endotracheal Intubation (INSURE Technique) Versus Laryngeal Mask Airway (LMA) for Respiratory Distress Syndrome (RDS) in Preterm Neonates Recruiting NCT02164734 Phase 4 remifentanil
26 Diaphragmatic Resection And Gynecological Ovarian Neoplasm Recruiting NCT03543462 Phase 4
27 Methadone and Interscalene Block for Shoulder Surgery Recruiting NCT03084588 Phase 4 methadone
28 Preoperative Controlled-Release Oxycodone or Intraoperative Morphine As Transition Opioid After Intravenous Anesthesia For Video-Assisted Thoracic Surgery: a Randomized, Double-blind, Controlled Trial. Terminated NCT00681174 Phase 4 Morphine;oxycodone;Propofol;Remifentanil;Paracetamol;Morphine
29 Pain Management After Total Shoulder Arthroplasty: Continuous Interscalene Block Versus Local Tissue Infiltration With Liposomal Bupivacaine Terminated NCT03219983 Phase 4 Ropivacaine;liposomal bupivacaine
30 Oral Corticosteroids Therapy and Interstitial Fibrosis in Patients With Pneumocystis Jirovecii Pneumonia (PCP) and pO2 of >70 at Presentation. Withdrawn NCT00636935 Phase 4 Antibiotics only;Antibiotics + Corticosteroids;Corticosteroids + antibiotics
31 Ultrasound-guided Thoracic Paravertebral Block Versus Ultrasound-guided Thoracic Erector Spinae Plane Block for Pain Management After Unilateral Total Mastectomy: a Randomized Controlled Trial Withdrawn NCT03490006 Phase 4
32 A Prospective Randomized Study of 14-French (14F) Pigtail Catheters Versus 28F Chest Tubes in Patients With Traumatic Pneumothorax: Impact on Tube-Site Pain and Failure Rate Unknown status NCT01537289 Phase 3
33 Comparison of Chest Tube Drainage Versus Thoracoscopic Surgery for Unsuccessful Aspiration of Primary Spontaneous Pneumothorax: a Prospective Randomized Trial Unknown status NCT00713362 Phase 2, Phase 3
34 Thoracoscopic Bullectomy With Absorbable Mesh Coverage of the Staple Line Versus Thoracoscopic Bullectomy Only for the Treatment of Primary Spontaneous Pneumothorax: a Single-blind, Parallel-group, Prospective, Randomized Controlled Trial Unknown status NCT01848860 Phase 2, Phase 3
35 Comparison of Pleural Abrasion Plus Minocycline Pleurodesis Versus Apical Pleurectomy After Thoracoscopic Bullectomy for High Recurrent Risk Patients With Primary Spontaneous Pneumothorax: A Prospective Randomized Trial. Unknown status NCT00270751 Phase 2, Phase 3
36 Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax: A Randomized Trial Unknown status NCT00418392 Phase 3
37 Prospective and Randomized Study Comparing 14 F Pigtail Catheter to Traditional 32-36F Chest Tube in the Management of Traumatic Hemothorax and Hemopneumothorax Unknown status NCT02553434 Phase 3
38 Lymphangioleiomyomatosis Efficacy and Safety Trial Unknown status NCT00414648 Phase 3 Sirolimus;Placebo sirolimus
39 Comparing of Computed Tomography Guided Microcoil Localization and Hook Wire Localization for Pulmonary Small Nodules and Ground-glass Opacity Prior to Thoracoscopic Resection Unknown status NCT02908646 Phase 3
40 Randomised Controlled Trial Comparing the Diagnostic Yield of Radial Endo-Bronchial Ultra-Sound (R-EBUS) Guided Cryo-biopsy Vs. CT-guided Transthoracic Biopsy in Patients With Parenchymal Lung Lesion, Suspected of Lung Cancer (CT-CROP) Unknown status NCT02395939 Phase 3
41 The NoTube Study: Evaluation of the Necessity of a Chest Tube After a Video-assisted Thoracoscopic Surgery Pulmonary Wedge Resection. Unknown status NCT00841750 Phase 3
42 Use of Orotracheal CPAP ( Gregory System) for Treatment of Respiratory Failure in Newborns Unknown status NCT01379820 Phase 2, Phase 3
43 Nasal Intermittent Mandatory Ventilation Versus Continuous Positive Airway Pressure After Extubation of Very Low Birth Weight Infants of the NEOCOSUR Network. Unknown status NCT01778829 Phase 3
44 Intranasal Midazolam Versus Intranasal Ketamine to Sedate Newborns for Intubation in Delivery Room. Unknown status NCT01517828 Phase 3 Sedation by ketamine;Sedation with Midazolam
45 Randomized Comparison of Cyclophosphamide Versus Fludarabine in Addition to Anti-thymocyte Globulin for the Conditioning Therapy in Allogeneic Hematopoietic Cell Transplantation for Adult Acquired Aplastic Anemia Unknown status NCT01145976 Phase 3 Cy-ATG;Flu-ATG
46 Phase III Study of Evaluation of the Efficacy of Additional Mechanical Pleurodesis After Thoracoscopic Wedge Resection for the Management of Primary Spontaneous Pneumothorax Completed NCT00615849 Phase 3
47 A Prospective, Randomized, Multi-centered Safety and Efficacy Evaluation of the Bio-Seal Track Plug for Reducing Pneumothorax Rates Post Lung Biopsy Completed NCT00562302 Phase 3
48 KatGuide-trial. KatGuide Method Versus Conventional Method at Insertion of Chest Tube. A Randomized, Parallel Group, Controlled Trial. Completed NCT01522885 Phase 3
49 The Role of Antibiotics in the Reduction of Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax: A Prospective, Double-Blinded Study Completed NCT01127880 Phase 2, Phase 3 Ancef or Clindamycin;Placebo
50 Efficacy and Safety of Continuous Infusion of Fentanyl for Pain Control in Preterm Newborn on Mechanical Ventilation Completed NCT00571636 Phase 3 Fentanyl;5% glucose solution

Search NIH Clinical Center for Pneumothorax

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Cochrane evidence based reviews: pneumothorax

Genetic Tests for Pneumothorax

Anatomical Context for Pneumothorax

MalaCards organs/tissues related to Pneumothorax:

Lung, Heart, Breast, Liver, Testes, Bone, Kidney

Publications for Pneumothorax

Articles related to Pneumothorax:

(show top 50) (show all 20213)
# Title Authors PMID Year
A Japanese family with multiple lung cysts and recurrent pneumothorax: a possibility of Birt-Hogg-Dubé syndrome. 9 38
19687589 2009
Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. 9 38
18663353 2008
Mutations of the Birt Hogg Dube gene in patients with multiple lung cysts and recurrent pneumothorax. 9 38
17496196 2007
Birt-Hogg-Dubé (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability. 9 38
16870330 2007
Novel mutations in the BHD gene and absence of loss of heterozygosity in fibrofolliculomas of Birt-Hogg-Dubé patients. 9 38
17124507 2007
Birt-Hogg-Dubé gene mutations in human endometrial carcinomas with microsatellite instability. 9 38
16691634 2006
Emerging clinical picture of lymphangioleiomyomatosis. 9 38
16055626 2005
Nonsense mutations in folliculin presenting as isolated familial spontaneous pneumothorax in adults. 9 38
15805188 2005
Endobronchial one-way valve for persistent air leak and lung volume reduction. 38
31341625 2019
First successful case of chemical pleurodesis with oxytetracycline through Rocket® Pleural Vent™: ambulatory pneumothorax device for pneumothorax. 38
31406578 2019
The Helpful Role of CD10 and Hormonal Receptors Co-Expression in the Histologic Diagnosis of Catamenial Pneumothorax. 38
31068050 2019
Competence in pleural procedures. 38
30394712 2019
Concurrence of Two Rare Conditions: Simultaneous Bilateral Spontaneous Pneumothorax and Congenital Pulmonary Airway Malformation. 38
31404456 2019
Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV). 38
30928294 2019
Competence in navigation and guided transbronchial biopsy for peripheral pulmonary lesions. 38
30394715 2019
Thoracic Manifestations of Ankylosing Spondylitis, Inflammatory Bowel Disease, and Relapsing Polychondritis. 38
31376894 2019
Transbronchial Lung Cryobiopsy in Idiopathic Pulmonary Fibrosis: A State of the Art Review. 38
31363997 2019
Whole-lung Lavage and Pulmonary Alveolar Proteinosis: Review of Clinical and Patient-centered Outcomes. 38
31307910 2019
Lung Pulse with Pneumothorax: Examine the Thoracic Artery and Veins. 38
31116103 2019
Reducing the risk of pneumothorax following erector spinae plane block. 38
30660813 2019
Post-Biopsy Manoeuvres to Reduce Pneumothorax Incidence in CT-Guided Transthoracic Lung Biopsies: A Systematic Review and Meta-analysis. 38
30863965 2019
Pneumothorax in neuromuscular disease associated with lung volume recruitment and mechanical insufflation-exsufflation. 38
31210952 2019
Anesthesia for peroral endoscopic myotomy in Japan. 38
30994477 2019
[Anaphylaxis Induced by Fibrin Glue During Surgery for Pneumothorax]. 38
31353353 2019
Pacemaker complications and costs: a nationwide economic study. 38
31373521 2019
Utility of pleural effusion drainage in the ICU: An updated systematic review and META-analysis. 38
30951925 2019
Electrical Impedance Tomography for Cardio-Pulmonary Monitoring. 38
31394721 2019
Video-Assisted Thoracic Surgery (VATS) Talc Pleurodesis Versus Pleurectomy for Primary Spontaneous Pneumothorax: A Large Single-Centre Study with No Conversion. 38
30972431 2019
Racial and Ethnic Differences Over Time in Outcomes of Infants Born Less Than 30 Weeks' Gestation. 38
31405887 2019
Is inspiratory muscle training (IMT) an acceptable treatment option for people with chronic obstructive pulmonary disease (COPD) who have declined pulmonary rehabilitation (PR) and can IMT enhance PR uptake? A single-group prepost feasibility study in a home-based setting. 38
31399454 2019
Clinico-radiologic features of pleuroparenchymal fibroelastosis in children. 38
31004186 2019
High prevalence of abnormalities on chest radiography in rheumatoid arthritis. 38
31396835 2019
Tension pneumothorax caused by iatrogenic intra-abdominal explosion during laparoscopic procedure. 38
30597456 2019
Endobronchial valve placement for a severe pneumothorax in a child on ECLS. 38
31400062 2019
Pneumothorax following combination chemotherapy with bevacizumab: A case report and review of the literature. 38
31281652 2019
Pneumothorax after minimally invasive plate osteosynthesis for midshaft clavicle fracture: A case report. 38
31415405 2019
Huge congenital cystic lung lesion mimicking tension pneumothorax in a child. 38
31339287 2019
Spontaneous Pneumothorax Due to Septic Pulmonary Embolism Caused by Methicillin-Resistant Staphylococcus Aureus. 38
31383497 2019
Longer symptom onset to aspiration time predicts success of needle aspiration in primary spontaneous pneumothorax. 38
31189731 2019
Clinical consequences of chest tube malposition in trauma resuscitation: single-center experience. 38
29855668 2019
Endoscopic thoracic sympathicotomy for primary palmar hyperhidrosis: A retrospective multicenter study in China. 38
31378477 2019
Percutaneous radiofrequency ablation using internally cooled wet electrodes for the treatment of patients with lung tumors. 38
31378896 2019
Characterization of all-terrain vehicle-related chest injury patterns in children. 38
30790115 2019
Thoracic Aortic Dissection Associated with Marijuana Use. 38
31126675 2019
Contemporary Mid-term Outcomes in Pediatric Patients undergoing Vascular Ring Repair. 38
31421105 2019
Ultrasound-guided percutaneous rib biopsy: a safe procedure with high diagnostic yield. 38
31084972 2019
Diagnostic Performance of 6-Point Lung Ultrasound in ICU Patients: A Comparison with Chest X-Ray and CT Thorax. 38
31380512 2019
[Delphi Expert Consensus of the German Thoracic Surgery Society on the Management of Chest Tube Drainage]. 38
31394582 2019
High-energy Pediatric Scapula Fractures and Their Associated Injuries. 38
31305382 2019
Comparison between the application of microcoil and hookwire for localizing pulmonary nodules. 38
30631924 2019

Variations for Pneumothorax

ClinVar genetic disease variations for Pneumothorax:

# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 COL5A1 NM_000093.4(COL5A1): c.608G> T (p.Gly203Val) single nucleotide variant Likely pathogenic rs1554781700 9:137593133-137593133 9:134701287-134701287
2 46;XY;t(20;22)(q13.3;q11.2) Translocation Uncertain significance

Expression for Pneumothorax

Search GEO for disease gene expression data for Pneumothorax.

Pathways for Pneumothorax

GO Terms for Pneumothorax

Cellular components related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 SERPINA1 MUC1 MMP9 MMP2 KDR FBN1
2 extracellular matrix GO:0031012 9.35 MMP9 MMP2 FBN1 ELN COL5A1
3 collagen-containing extracellular matrix GO:0062023 9.1 SERPINA1 MMP9 MMP2 FBN1 ELN COL5A1

Biological processes related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of protein phosphorylation GO:0001932 9.54 FNIP2 FNIP1 FLCN
2 TOR signaling GO:0031929 9.4 FNIP1 FLCN
3 extracellular matrix organization GO:0030198 9.35 MMP9 KDR FBN1 ELN COL5A1
4 negative regulation of TOR signaling GO:0032007 9.33 TSC1 FNIP1 FLCN
5 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.32 NFE2L2 MUC1
6 regulation of pro-B cell differentiation GO:2000973 9.26 FNIP1 FLCN
7 positive regulation of protein phosphorylation GO:0001934 8.92 MMP9 KDR FNIP1 FLCN

Molecular functions related to Pneumothorax according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 TSC1 SLC22A4 SERPINA1 PGR NFE2L2 MUC1
2 identical protein binding GO:0042802 9.8 SERPINA1 PGR MMP9 KDR FBN1 ALK
3 integrin binding GO:0005178 9.58 KDR FBN1 COL5A1
4 extracellular matrix structural constituent GO:0005201 9.54 FBN1 ELN COL5A1
5 chaperone binding GO:0051087 9.43 TSC1 FNIP2 FNIP1
6 extracellular matrix constituent conferring elasticity GO:0030023 9.16 FBN1 ELN
7 ATPase inhibitor activity GO:0042030 8.8 TSC1 FNIP2 FNIP1

Sources for Pneumothorax

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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