Aliases & Classifications for Podoconiosis

MalaCards integrated aliases for Podoconiosis:

Name: Podoconiosis 57 12 15 73
Podoconiosis, Susceptibility to 57 13
Nonfilarial Elephantiasis of Lower Legs, Susceptibility to 57
Endemic Nonfilarial Elephantiasis, Susceptibility to 57
Lymphostatic Verrucosis, Susceptibility to 57
Nonfilarial Elephantiasis of Lower Legs 57
Endemic Non-Filarial Elephantiasis 73
Endemic Nonfilarial Elephantiasis 57
Lymphostatic Verrucosis 57
Pdcos 57

Classifications:



External Ids:

OMIM 57 614590
Disease Ontology 12 DOID:0050138

Summaries for Podoconiosis

OMIM : 57 Podoconiosis, or endemic nonfilarial elephantiasis, is a noninfectious geochemical disease characterized by edema of the foot and lower leg that progresses to severe elephantiasis. It is a chronic and debilitating disorder that is a public health problem in at least 10 countries in tropical Africa, Central America, and northern India. Podoconiosis occurs among subsistence farmers and other occupational groups whose feet are exposed over many years to red clay soil derived from alkalic volcanic rock. However, podoconiosis develops only in a subgroup of exposed people, and studies have shown familial clustering with high heritability (summary by Davey et al. (2007) and Tekola Ayele et al. (2012)). (614590)

MalaCards based summary : Podoconiosis, also known as podoconiosis, susceptibility to, is related to elephantiasis and filarial elephantiasis. An important gene associated with Podoconiosis is PDCOS (Podoconiosis, Susceptibility To), and among its related pathways/superpathways is Cell adhesion molecules (CAMs). The drugs Glycerol and Petrolatum have been mentioned in the context of this disorder. Affiliated tissues include skin and testes.

Wikipedia : 76 Podoconiosis, also known as nonfilarial elephantiasis, is a disease of the lymphatic vessels of the... more...

Related Diseases for Podoconiosis

Diseases related to Podoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 elephantiasis 10.4
2 filarial elephantiasis 10.3
3 filariasis 10.1
4 lymphedema 10.1
5 aging 9.8
6 cataract 9.8
7 onchocerciasis 9.8
8 depression 9.8

Graphical network of the top 20 diseases related to Podoconiosis:



Diseases related to Podoconiosis

Symptoms & Phenotypes for Podoconiosis

Clinical features from OMIM:

614590

Drugs & Therapeutics for Podoconiosis

Drugs for Podoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Investigational Phase 3 56-81-5 753
2
Petrolatum Approved, Investigational Phase 3 8009-03-8
3 Sodium hypochlorite Phase 3
4 Disinfectants Phase 3
5 Eusol Phase 3
6 Anti-Infective Agents Phase 3
7 Protective Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
2 Promoting Consistent Shoe Use Among Children At High Risk for Podoconiosis Completed NCT01160523
3 Genetic and Other Aspects of Podoconiosis Not yet recruiting NCT01939431

Search NIH Clinical Center for Podoconiosis

Genetic Tests for Podoconiosis

Anatomical Context for Podoconiosis

MalaCards organs/tissues related to Podoconiosis:

41
Skin, Testes

Publications for Podoconiosis

Articles related to Podoconiosis:

(show top 50) (show all 101)
# Title Authors Year
1
Integrated morbidity mapping of lymphatic filariasis and podoconiosis cases in 20 co-endemic districts of Ethiopia. ( 29965963 )
2018
2
Study of lymphoedema of non-filarial origin in the northwest region of Cameroon: spatial distribution, profiling of cases and socio-economic aspects of podoconiosis. ( 29771349 )
2018
3
Integrated care programme for acute episodes in patients with podoconiosis. ( 29773515 )
2018
4
Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema. ( 29324858 )
2018
5
Predicted distribution and burden of podoconiosis in Cameroon. ( 29946487 )
2018
6
Podoconiosis: Nonfilarial endemic elephantiasis. ( 29371058 )
2018
7
Global epidemiology of podoconiosis: A systematic review. ( 29494642 )
2018
8
Lymphoedema management to prevent acute dermatolymphangioadenitis in podoconiosis in northern Ethiopia (GoLBeT): a pragmatic randomised controlled trial. ( 29773516 )
2018
9
A Comparative Analysis of Economic Cost of Podoconiosis and Leprosy on Affected Households in the Northwest Region of Cameroon. ( 29460727 )
2018
10
Podoconiosis Is the Diagnosis. ( 28632875 )
2017
11
Soil iron and aluminium concentrations and feet hygiene as possible predictors of Podoconiosis occurrence in Kenya. ( 28832604 )
2017
12
Integrated morbidity management for lymphatic filariasis and podoconiosis, Ethiopia. ( 28867846 )
2017
13
Washing with water and glycerine improves skin barrier function and quality of life in patients with podoconiosis. ( 29192997 )
2017
14
Podoconiosis in Ethiopia: From Neglect to Priority Public Health Problem. ( 28878431 )
2017
15
Health beliefs of school-age rural children in podoconiosis-affected families: A qualitative study in Southern Ethiopia. ( 28542227 )
2017
16
Podoconiosis, trachomatous trichiasis and cataract in northern Ethiopia: A comparative cross sectional study. ( 28187129 )
2017
17
Estimating the number of cases of podoconiosis in Ethiopia using geostatistical methods. ( 29152596 )
2017
18
Determinants of Podoconiosis, a Case Control Study. ( 29217955 )
2017
19
Surgical nodulectomies can heal in patients with lymphoedema secondary to podoconiosis in resource-poor settings. ( 28256715 )
2017
20
Haemolytic activity of soil from areas of varying podoconiosis endemicity in Ethiopia. ( 28493920 )
2017
21
Risk Factors for Podoconiosis: Kamwenge District, Western Uganda, September 2015. ( 28719274 )
2017
22
A Randomised Controlled Trial to evaluate the effect of a new skin care regimen on skin barrier function in those with podoconiosis in Ethiopia. ( 28374907 )
2017
23
The global atlas of podoconiosis. ( 28395836 )
2017
24
Podoconiosis in Rural Tanzania. ( 27385665 )
2016
25
Dual Perspectives On Stigma: Reports of Experienced and Enacted Stigma by Those Affected and Unaffected by Podoconiosis. ( 27747202 )
2016
26
Burden assessment of podoconiosis in Wayu Tuka woreda, east Wollega zone, western Ethiopia: a community-based cross-sectional study. ( 27670520 )
2016
27
Association Between Causal Beliefs and Shoe Wearing to Prevent Podoconiosis: A Baseline Study. ( 26928843 )
2016
28
Willingness to pay for footwear, and associated factors related to podoconiosis in northern Ethiopia. ( 27620919 )
2016
29
Using Qualitative Methods to Explore Lay Explanatory Models, Health-Seeking Behaviours and Self-Care Practices of Podoconiosis Patients in North-West Ethiopia. ( 27536772 )
2016
30
Preparing for and Executing a Randomised Controlled Trial of Podoconiosis Treatment in Northern Ethiopia: The Utility of Rapid Ethical Assessment. ( 26967654 )
2016
31
Detecting and staging podoconiosis cases in North West Cameroon: positive predictive value of clinical screening of patients by community health workers and researchers. ( 27650390 )
2016
32
Mapping and Modelling the Geographical Distribution and Environmental Limits of Podoconiosis in Ethiopia. ( 26222887 )
2015
33
Reasons for loss to follow-up of patients with podoconiosis in the Amhara Region, northern Ethiopia. ( 25576138 )
2015
34
The feasibility of eliminating podoconiosis. ( 26600613 )
2015
35
Podoconiosis treatment in northern Ethiopia (GoLBet): study protocol for a randomised controlled trial. ( 26177812 )
2015
36
Depression and disability in people with podoconiosis: a comparative cross-sectional study in rural Northern Ethiopia. ( 26113669 )
2015
37
Measuring elimination of podoconiosis, endemicity classifications, case definition and targets: an international Delphi exercise. ( 26185194 )
2015
38
Epidemiology of elephantiasis with special emphasis on podoconiosis in Ethiopia: A literature review. ( 26119541 )
2015
39
Integrated mapping of lymphatic filariasis and podoconiosis: lessons learnt from Ethiopia. ( 25164687 )
2014
40
Extent of podoconiosis-related stigma in Wolaita Zone, Southern Ethiopia: a cross-sectional study. ( 25485190 )
2014
41
Podoconiosis patients' willingness to pay for treatment services in Northwest Ethiopia: potential for cost recovery. ( 24642085 )
2014
42
Barriers to access and re-attendance for treatment of podoconiosis: a qualitative study in northern Ethiopia. ( 25540135 )
2014
43
Histopathological and immunohistochemical features of nodular podoconiosis. ( 25401490 )
2014
44
How soil scientists help combat podoconiosis, a neglected tropical disease. ( 24828083 )
2014
45
How 'The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks' has underpinned progress in podoconiosis research. ( 25059525 )
2014
46
Mental distress and podoconiosis in Northern Ethiopia: a comparative cross-sectional study. ( 25062906 )
2014
47
Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis. ( 24946801 )
2014
48
Epidemiology and Individual, Household and Geographical Risk Factors of Podoconiosis in Ethiopia: Results from the First Nationwide Mapping. ( 25404069 )
2014
49
Ten years of podoconiosis research in Ethiopia. ( 24130908 )
2013
50
Stigma towards a Neglected Tropical Disease: Felt and enacted Stigma Scores among Podoconiosis Patients in Northern Ethiopia. ( 24330684 )
2013

Variations for Podoconiosis

Expression for Podoconiosis

Search GEO for disease gene expression data for Podoconiosis.

Pathways for Podoconiosis

Pathways related to Podoconiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.78 HLA-DQA1 NEGR1

GO Terms for Podoconiosis

Cellular components related to Podoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.13 HLA-DQA1 INSRR SLC24A5
2 trans-Golgi network membrane GO:0032588 8.62 HLA-DQA1 SLC24A5

Sources for Podoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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