PDCOS
MCID: PDC001
MIFTS: 36

Podoconiosis (PDCOS)

Categories: Immune diseases

Aliases & Classifications for Podoconiosis

MalaCards integrated aliases for Podoconiosis:

Name: Podoconiosis 57 12 15 73
Podoconiosis, Susceptibility to 57 13
Nonfilarial Elephantiasis of Lower Legs, Susceptibility to 57
Endemic Nonfilarial Elephantiasis, Susceptibility to 57
Lymphostatic Verrucosis, Susceptibility to 57
Nonfilarial Elephantiasis of Lower Legs 57
Endemic Non-Filarial Elephantiasis 73
Endemic Nonfilarial Elephantiasis 57
Lymphostatic Verrucosis 57
Elephantiasis 44
Pdcos 57

Classifications:



External Ids:

OMIM 57 614590
Disease Ontology 12 DOID:0050138
MeSH 44 D004604

Summaries for Podoconiosis

OMIM : 57 Podoconiosis, or endemic nonfilarial elephantiasis, is a noninfectious geochemical disease characterized by edema of the foot and lower leg that progresses to severe elephantiasis. It is a chronic and debilitating disorder that is a public health problem in at least 10 countries in tropical Africa, Central America, and northern India. Podoconiosis occurs among subsistence farmers and other occupational groups whose feet are exposed over many years to red clay soil derived from alkalic volcanic rock. However, podoconiosis develops only in a subgroup of exposed people, and studies have shown familial clustering with high heritability (summary by Davey et al. (2007) and Tekola Ayele et al. (2012)). (614590)

MalaCards based summary : Podoconiosis, also known as podoconiosis, susceptibility to, is related to elephantiasis and hydrocele. An important gene associated with Podoconiosis is PDCOS (Podoconiosis, Susceptibility To), and among its related pathways/superpathways is Cell adhesion molecules (CAMs). The drugs Petrolatum and Glycerol have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and heart.

Disease Ontology : 12 An elephantiasis that is characterized by lymphadema located in the lower extremities caused by a genetically determined abnormal inflammatory reaction to mineral particles in irritant red clay soils derived from volcanic deposits.

Wikipedia : 76 Podoconiosis, also known as nonfilarial elephantiasis, is a disease of the lymphatic vessels of the... more...

Related Diseases for Podoconiosis

Diseases related to Podoconiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 elephantiasis 30.3 INSRR SLC24A5
2 hydrocele 11.4
3 loiasis 11.0
4 filarial elephantiasis 10.5
5 filariasis 10.3
6 yaws 10.3
7 lymphangitis 10.3
8 lymphedema 10.2
9 neurofibromatosis, type i 10.1
10 erysipelas 10.1
11 lymphadenitis 10.1
12 hidradenitis suppurativa 10.1
13 hidradenitis 10.1
14 lymphangiosarcoma 10.1
15 morbid obesity 10.0
16 neurofibroma 10.0
17 cataract 10.0
18 onchocerciasis 10.0
19 depression 10.0
20 angiosarcoma 9.9
21 venous insufficiency 9.9
22 sarcoma 9.9
23 graves' disease 9.9
24 lymphogranuloma venereum 9.9
25 congenital lymphedema 9.9
26 kaposi sarcoma 9.8
27 lichen sclerosus et atrophicus 9.8
28 neurofibromatosis, type iv, of riccardi 9.8
29 scleroderma, familial progressive 9.8
30 neural tube defects 9.8
31 varicose veins 9.8
32 malaria 9.8
33 congestive heart failure 9.8
34 cutaneous leishmaniasis 9.8
35 diabetic neuropathy 9.8
36 basidiobolomycosis 9.8
37 hereditary lymphedema 9.8
38 chronic venous insufficiency 9.8
39 ptosis 9.8
40 myelomeningocele 9.8
41 sleeping sickness 9.8
42 osteomyelitis 9.8
43 chlamydia 9.8
44 tetanus 9.8
45 dysentery 9.8
46 cholera 9.8
47 angioedema 9.8
48 chromoblastomycosis 9.8
49 ectropion 9.8
50 cheilitis 9.8

Graphical network of the top 20 diseases related to Podoconiosis:



Diseases related to Podoconiosis

Symptoms & Phenotypes for Podoconiosis

Clinical features from OMIM:

614590

Drugs & Therapeutics for Podoconiosis

Drugs for Podoconiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Petrolatum Approved, Investigational Phase 3 8009-03-8
2
Glycerol Approved, Investigational Phase 3 56-81-5 753
3 Disinfectants Phase 3
4 Protective Agents Phase 3
5 Eusol Phase 3
6 Anti-Infective Agents Phase 3
7 Sodium hypochlorite Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
2 Promoting Consistent Shoe Use Among Children At High Risk for Podoconiosis Completed NCT01160523
3 Genetic and Other Aspects of Podoconiosis Not yet recruiting NCT01939431

Search NIH Clinical Center for Podoconiosis

Cochrane evidence based reviews: elephantiasis

Genetic Tests for Podoconiosis

Anatomical Context for Podoconiosis

MalaCards organs/tissues related to Podoconiosis:

41
Skin, Testes, Heart

The Foundational Model of Anatomy Ontology organs/tissues related to Podoconiosis:

19
The Lower Extremities

Publications for Podoconiosis

Articles related to Podoconiosis:

(show top 50) (show all 114)
# Title Authors Year
1
Integrated morbidity mapping of lymphatic filariasis and podoconiosis cases in 20 co-endemic districts of Ethiopia. ( 29965963 )
2018
2
Study of lymphoedema of non-filarial origin in the northwest region of Cameroon: spatial distribution, profiling of cases and socio-economic aspects of podoconiosis. ( 29771349 )
2018
3
Integrated care programme for acute episodes in patients with podoconiosis. ( 29773515 )
2018
4
Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema. ( 29324858 )
2018
5
Predicted distribution and burden of podoconiosis in Cameroon. ( 29946487 )
2018
6
Podoconiosis: Nonfilarial endemic elephantiasis. ( 29371058 )
2018
7
Global epidemiology of podoconiosis: A systematic review. ( 29494642 )
2018
8
Lymphoedema management to prevent acute dermatolymphangioadenitis in podoconiosis in northern Ethiopia (GoLBeT): a pragmatic randomised controlled trial. ( 29773516 )
2018
9
A Comparative Analysis of Economic Cost of Podoconiosis and Leprosy on Affected Households in the Northwest Region of Cameroon. ( 29460727 )
2018
10
A comparison between paper-based and m-Health tools for collating and reporting clinical cases of lymphatic filariasis and podoconiosis in Ethiopia. ( 30505847 )
2018
11
A Human Right to Shoes? Establishing Rights and Duties in the Prevention and Treatment of Podoconiosis. ( 30008552 )
2018
12
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia. ( 30101228 )
2018
13
Podoconiosis research to implementation: a call for global action. ( 30103988 )
2018
14
Lymphoedema management in podoconiosis. ( 30103994 )
2018
15
Lymphoedema management in podoconiosis - Authors reply. ( 30103995 )
2018
16
Podoconiosis today: challenges and opportunities. ( 30137612 )
2018
17
Regional bedrock geochemistry associated with podoconiosis evaluated by multivariate analysis. ( 30187152 )
2018
18
Rural youths' understanding of gene x environmental contributors to heritable health conditions: The case of podoconiosis in Ethiopia. ( 30212466 )
2018
19
Podoconiosis pathogenesis: renewed use of an historical archive. ( 30239941 )
2018
20
Involvement of Hookworm Co-Infection in the Pathogenesis and Progression of Podoconiosis: Possible Immunological Mechanism. ( 30274434 )
2018
21
Community Involvement in the Care of Persons Affected by Podoconiosis-A Lesson for Other Skin NTDs. ( 30274483 )
2018
22
'I should not feed such a weak woman'. Intimate partner violence among women living with podoconiosis: A qualitative study in northern Ethiopia. ( 30521548 )
2018
23
Podoconiosis Is the Diagnosis. ( 28632875 )
2017
24
Soil iron and aluminium concentrations and feet hygiene as possible predictors of Podoconiosis occurrence in Kenya. ( 28832604 )
2017
25
Integrated morbidity management for lymphatic filariasis and podoconiosis, Ethiopia. ( 28867846 )
2017
26
Washing with water and glycerine improves skin barrier function and quality of life in patients with podoconiosis. ( 29192997 )
2017
27
Podoconiosis in Ethiopia: From Neglect to Priority Public Health Problem. ( 28878431 )
2017
28
Health beliefs of school-age rural children in podoconiosis-affected families: A qualitative study in Southern Ethiopia. ( 28542227 )
2017
29
Podoconiosis, trachomatous trichiasis and cataract in northern Ethiopia: A comparative cross sectional study. ( 28187129 )
2017
30
Estimating the number of cases of podoconiosis in Ethiopia using geostatistical methods. ( 29152596 )
2017
31
Determinants of Podoconiosis, a Case Control Study. ( 29217955 )
2017
32
Surgical nodulectomies can heal in patients with lymphoedema secondary to podoconiosis in resource-poor settings. ( 28256715 )
2017
33
Haemolytic activity of soil from areas of varying podoconiosis endemicity in Ethiopia. ( 28493920 )
2017
34
Risk Factors for Podoconiosis: Kamwenge District, Western Uganda, September 2015. ( 28719274 )
2017
35
A Randomised Controlled Trial to evaluate the effect of a new skin care regimen on skin barrier function in those with podoconiosis in Ethiopia. ( 28374907 )
2017
36
The global atlas of podoconiosis. ( 28395836 )
2017
37
Podoconiosis in Rural Tanzania. ( 27385665 )
2016
38
Dual Perspectives On Stigma: Reports of Experienced and Enacted Stigma by Those Affected and Unaffected by Podoconiosis. ( 27747202 )
2016
39
Burden assessment of podoconiosis in Wayu Tuka woreda, east Wollega zone, western Ethiopia: a community-based cross-sectional study. ( 27670520 )
2016
40
Association Between Causal Beliefs and Shoe Wearing to Prevent Podoconiosis: A Baseline Study. ( 26928843 )
2016
41
Willingness to pay for footwear, and associated factors related to podoconiosis in northern Ethiopia. ( 27620919 )
2016
42
Using Qualitative Methods to Explore Lay Explanatory Models, Health-Seeking Behaviours and Self-Care Practices of Podoconiosis Patients in North-West Ethiopia. ( 27536772 )
2016
43
Preparing for and Executing a Randomised Controlled Trial of Podoconiosis Treatment in Northern Ethiopia: The Utility of Rapid Ethical Assessment. ( 26967654 )
2016
44
Detecting and staging podoconiosis cases in North West Cameroon: positive predictive value of clinical screening of patients by community health workers and researchers. ( 27650390 )
2016
45
Mapping and Modelling the Geographical Distribution and Environmental Limits of Podoconiosis in Ethiopia. ( 26222887 )
2015
46
Reasons for loss to follow-up of patients with podoconiosis in the Amhara Region, northern Ethiopia. ( 25576138 )
2015
47
The feasibility of eliminating podoconiosis. ( 26600613 )
2015
48
Podoconiosis treatment in northern Ethiopia (GoLBet): study protocol for a randomised controlled trial. ( 26177812 )
2015
49
Depression and disability in people with podoconiosis: a comparative cross-sectional study in rural Northern Ethiopia. ( 26113669 )
2015
50
Measuring elimination of podoconiosis, endemicity classifications, case definition and targets: an international Delphi exercise. ( 26185194 )
2015

Variations for Podoconiosis

Expression for Podoconiosis

Search GEO for disease gene expression data for Podoconiosis.

Pathways for Podoconiosis

Pathways related to Podoconiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.78 HLA-DQA1 NEGR1

GO Terms for Podoconiosis

Cellular components related to Podoconiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network membrane GO:0032588 8.62 HLA-DQA1 SLC24A5

Sources for Podoconiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....