MCID: PMS001
MIFTS: 64

Poems Syndrome

Categories: Blood diseases, Bone diseases, Immune diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Poems Syndrome

MalaCards integrated aliases for Poems Syndrome:

Name: Poems Syndrome 12 76 53 59 55 44 15 73
Crow-Fukase Syndrome 53 59 37
Osteosclerotic Myeloma 59 73
Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome 53
Polyneuropathy-Endocrinopathy-Plasma Cell Dyscrasia Syndrome 59
Polyneuropathy Organomegaly 53
Takatsuki Syndrome 59
Pep Syndrome 59

Characteristics:

Orphanet epidemiological data:

59
poems syndrome
Age of onset: Adult,Elderly; Age of death: adult,elderly,normal life expectancy;

Classifications:



Summaries for Poems Syndrome

NIH Rare Diseases : 53 POEMS syndrome is a rare, mulitisystem disorder. POEMS stands for the disorder's features, which may include Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes. Signs and symptoms may include progressive sensorimotor polyneuropathy; enlarged liver, spleen, and/or lymph nodes; a disorder of the endocrine glands (often with multiple abnormalities); a monoclonal plasma cell proliferative disorder; and darkening of the skin (hyperpigmentation). Various other symptoms may also occur and may vary among affected people. The underlying cause of the disorder is not well understood. POEMS syndrome is a chronic disorder, with a median survival time of 8-14 years. There is no standard treatment; management depends on the underlying plasma cell disorder and may include radiation therapy, chemotherapy, and/or hematopoietic cell transplantation.

MalaCards based summary : Poems Syndrome, also known as crow-fukase syndrome, is related to extramedullary plasmacytoma and castleman disease. An important gene associated with Poems Syndrome is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are TGF-Beta Pathway and Human cytomegalovirus infection. The drugs Dexamethasone acetate and Lenalidomide have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and bone, and related phenotypes are diabetes mellitus and hypothyroidism

Wikipedia : 76 POEMS syndrome (also termed osteosclerotic myeloma, Crow�??Fukase syndrome, Takatsuki disease, or PEP... more...

Related Diseases for Poems Syndrome

Diseases related to Poems Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 368)
# Related Disease Score Top Affiliating Genes
1 extramedullary plasmacytoma 30.8 IL6 MYOM2
2 castleman disease 30.8 IL6 VEGFA
3 glomeruloid hemangioma 30.5 MYOM2 VEGFA
4 hematopoietic stem cell transplantation 30.3 IL6 TNF
5 plasma cell neoplasm 30.1 IL6 MYOM2
6 osteosclerotic myeloma 30.0 IL1B IL6 MYOM2 TNF
7 macular retinal edema 30.0 IL6 VEGFA
8 peripheral nervous system disease 30.0 IL6 MYOM2 TNF
9 pericardial effusion 29.9 IL6 VEGFA
10 retinal artery occlusion 29.9 IL6 VEGFA
11 arthritis 29.7 IL1B IL6 TNF
12 rheumatoid arthritis 29.5 IL1B IL6 TNF VEGFA
13 myeloma, multiple 29.5 EPO IL6 MYOM2 TNF VEGFA
14 end stage renal failure 29.3 EPO IL6 TNF
15 myocardial infarction 29.2 IL1B IL6 TNF VEGFA
16 diabetes mellitus 28.8 EPO IL1B IL6 TNF VEGFA
17 polyneuropathy 10.6
18 hemangioma 10.3
19 pulmonary hypertension 10.3
20 beriberi 10.3
21 neuropathy 10.3
22 arteriovenous malformations of the brain 10.2 IL6 VEGFA
23 intermittent claudication 10.2 IL6 VEGFA
24 retinal vein occlusion 10.2 IL6 VEGFA
25 peripheral artery disease 10.2 IL6 VEGFA
26 arteriovenous malformation 10.2 IL6 VEGFA
27 central retinal vein occlusion 10.2 IL6 VEGFA
28 breast carcinoma in situ 10.2 IL6 VEGFA
29 diabetic macular edema 10.2 IL6 VEGFA
30 plasmacytoma 10.2
31 dupuytren contracture 10.2 IL1B VEGFA
32 keratitis, hereditary 10.2 IL1B VEGFA
33 preterm premature rupture of the membranes 10.2 IL1B IL6
34 newborn respiratory distress syndrome 10.2 IL1B IL6
35 gingival disease 10.2 IL1B IL6
36 calciphylaxis 10.2
37 mature b-cell neoplasm 10.2 IL6 MYOM2
38 necrotizing fasciitis 10.2 IL6 MYOM2
39 demyelinating polyneuropathy 10.2
40 recurrent corneal erosion 10.2 IL1B IL6
41 bagassosis 10.1 IL1B IL6
42 pharyngitis 10.1 IL1B MYOM2
43 retinal ischemia 10.1 TNF VEGFA
44 paraneoplastic syndromes 10.1 IL1B IL6
45 periodontitis, chronic 10.1 IL1B IL6
46 geographic tongue 10.1 TNF VEGFA
47 spinal disease 10.1 IL6 VEGFA
48 lymphangiosarcoma 10.1 TNF VEGFA
49 hepatopulmonary syndrome 10.1 TNF VEGFA
50 tuberculous meningitis 10.1 TNF VEGFA

Graphical network of the top 20 diseases related to Poems Syndrome:



Diseases related to Poems Syndrome

Symptoms & Phenotypes for Poems Syndrome

Human phenotypes related to Poems Syndrome:

59 32 (show all 46)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 diabetes mellitus 59 32 frequent (33%) Frequent (79-30%) HP:0000819
2 hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0000821
3 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
4 acrocyanosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001063
5 respiratory insufficiency due to muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0002747
6 ascites 59 32 frequent (33%) Frequent (79-30%) HP:0001541
7 pulmonary arterial hypertension 59 32 frequent (33%) Frequent (79-30%) HP:0002092
8 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
9 venous thrombosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004936
10 lipodystrophy 59 32 occasional (7.5%) Occasional (29-5%) HP:0009125
11 paresthesia 59 32 frequent (33%) Frequent (79-30%) HP:0003401
12 primary adrenal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008207
13 hypogonadism 59 32 hallmark (90%) Very frequent (99-80%) HP:0000135
14 pain 59 32 frequent (33%) Frequent (79-30%) HP:0012531
15 thrombocytosis 59 32 frequent (33%) Frequent (79-30%) HP:0001894
16 areflexia 59 32 frequent (33%) Frequent (79-30%) HP:0001284
17 thickened skin 59 32 frequent (33%) Frequent (79-30%) HP:0001072
18 papilledema 59 32 frequent (33%) Frequent (79-30%) HP:0001085
19 gynecomastia 59 32 frequent (33%) Frequent (79-30%) HP:0000771
20 erectile abnormalities 59 32 frequent (33%) Frequent (79-30%) HP:0100639
21 arterial thrombosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004420
22 lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002716
23 polycythemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001901
24 visceromegaly 59 32 hallmark (90%) Very frequent (99-80%) HP:0003271
25 polyneuropathy 59 32 obligate (100%) Obligate (100%) HP:0001271
26 increased antibody level in blood 59 32 hallmark (90%) Very frequent (99-80%) HP:0010702
27 hyperesthesia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100963
28 pleural effusion 59 32 frequent (33%) Frequent (79-30%) HP:0002202
29 restrictive deficit on pulmonary function testing 59 32 occasional (7.5%) Occasional (29-5%) HP:0002111
30 hyperpigmentation of the skin 59 32 frequent (33%) Frequent (79-30%) HP:0000953
31 prolactin excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000870
32 hemangioma 59 32 frequent (33%) Frequent (79-30%) HP:0001028
33 clubbing of fingers 59 32 frequent (33%) Frequent (79-30%) HP:0100759
34 pericardial effusion 59 32 frequent (33%) Frequent (79-30%) HP:0001698
35 leukonychia 59 32 frequent (33%) Frequent (79-30%) HP:0001820
36 hypertrichosis 59 32 frequent (33%) Frequent (79-30%) HP:0000998
37 lymphoproliferative disorder 59 32 hallmark (90%) Very frequent (99-80%) HP:0005523
38 metaphyseal sclerosis 59 32 frequent (33%) Frequent (79-30%) HP:0004979
39 abnormality of skin physiology 59 32 hallmark (90%) Very frequent (99-80%) HP:0011122
40 sclerosis of skull base 59 32 frequent (33%) Frequent (79-30%) HP:0002694
41 sclerosis of hand bone 59 32 frequent (33%) Frequent (79-30%) HP:0004054
42 sclerotic vertebral endplates 59 32 frequent (33%) Frequent (79-30%) HP:0004576
43 sclerosis of foot bone 59 32 frequent (33%) Frequent (79-30%) HP:0100925
44 muscle weakness 59 Frequent (79-30%)
45 edema 59 Frequent (79-30%)
46 abnormality of the endocrine system 59 Very frequent (99-80%)

MGI Mouse Phenotypes related to Poems Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 EPO IL1B IL6 PTX3 TNF VEGFA
2 immune system MP:0005387 9.73 EPO IL1B IL6 PTX3 TNF VEGFA
3 integument MP:0010771 9.55 EPO IL1B IL6 TNF VEGFA
4 neoplasm MP:0002006 9.26 IL1B IL6 TNF VEGFA
5 respiratory system MP:0005388 9.02 EPO IL6 PTX3 TNF VEGFA

Drugs & Therapeutics for Poems Syndrome

Drugs for Poems Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
2
Lenalidomide Approved Phase 2 191732-72-6 216326
3
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
4 Ixazomib Approved, Investigational Phase 2 1072833-77-2
5
Glycine Approved, Nutraceutical, Vet_approved Phase 2 56-40-6 750
6
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
8 Antineoplastic Agents, Hormonal Phase 2
9
protease inhibitors Phase 2
10 Anti-Bacterial Agents Phase 2
11 Antiemetics Phase 2
12 Anti-Inflammatory Agents Phase 2
13 Hormone Antagonists Phase 2
14 Immunosuppressive Agents Phase 2
15 Angiogenesis Modulating Agents Phase 2
16 glucocorticoids Phase 2
17 Autonomic Agents Phase 2
18 BB 1101 Phase 2
19 Peripheral Nervous System Agents Phase 2
20 Hormones Phase 2
21 Immunologic Factors Phase 2
22 Gastrointestinal Agents Phase 2
23 Angiogenesis Inhibitors Phase 2
24 HIV Protease Inhibitors Phase 2
25 Anti-Infective Agents Phase 2
26 Anticoagulants Phase 2
27 Calcium, Dietary Phase 2
28 Chelating Agents Phase 2
29 Citrate Phase 2
30 Neurotransmitter Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 POEMS Syndrome Treatment With Lenalidomide Unknown status NCT01639898 Phase 2 Lenalidomide and dexamethasone;Lenalidomide and dexamethasone
2 The Treatment of Lenalidomide in Patients With POEMS Syndrome Unknown status NCT00971685 Phase 2 Lenalidomide and dexamethasone
3 Study to Evaluate Lenalidomide Plus Dexamethasone in Patients With Newly Diagnosed POEMS Syndrome Completed NCT01816620 Phase 2 Lenalidomide, Dexamethasone
4 Efficacy and Safety of Lenalidomide as a Treatment for Recurrent or Refractory POEMS Syndrome Trial Completed NCT02193698 Phase 2 Lenalidomide+Dexamethasone
5 Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome Recruiting NCT02921893 Phase 2 Dexamethasone;Ixazomib Citrate;Lenalidomide
6 Registry for Adults With Plasma Cell Disorders (PCD's) Recruiting NCT03717844

Search NIH Clinical Center for Poems Syndrome

Cochrane evidence based reviews: poems syndrome

Genetic Tests for Poems Syndrome

Anatomical Context for Poems Syndrome

MalaCards organs/tissues related to Poems Syndrome:

41
Skin, Endothelial, Bone, Lymph Node, Liver, Spleen, Heart

Publications for Poems Syndrome

Articles related to Poems Syndrome:

(show top 50) (show all 648)
# Title Authors Year
1
Cutaneous manifestations as a clue to the diagnosis of POEMS syndrome. ( 29921722 )
2018
2
What is the place of POEMS syndrome in the current classification of monoclonal gammopathies of renal significance? ( 29134615 )
2018
3
Hepatobiliary and Pancreatic: Obliterative portal venopathy found in Castleman disease variant of POEMS syndrome. ( 29691905 )
2018
4
Cutaneous Mycobacterium chelonae infection following autologous peripheral blood stem cell transplantation for POEMS syndrome. ( 29861185 )
2018
5
Atypical central retinal artery occlusion as the first presentation of POEMS syndrome: a case report. ( 29739345 )
2018
6
RETINAL MICROSTRUCTURE IN POEMS SYNDROME. ( 29547451 )
2018
7
Skull base plasmacytoma: A unique case of POEMS syndrome with a plasmacytoma causing craniocervical instability. ( 29100675 )
2018
8
An atypical presentation of POEMS syndrome with IgG kappa type M protein and normal VEGF level: Case report and review of literature. ( 29893339 )
2018
9
Long-term evaluation of physical improvement and survival of autologous stem cell transplantation in POEMS syndrome. ( 29599110 )
2018
10
The Efficacy and Long-Term Outcomes of Autologous Stem Cell Transplantation in POEMS Syndrome: a Nation-Wide Survey in Japan. ( 29409882 )
2018
11
Prognostic value of serum vascular endothelial growth factor and hematological responses in patients with newly-diagnosed POEMS syndrome. ( 29618787 )
2018
12
Reduction of Optic Disc Oedema by Bortezomib and Dexamethasone Followed by Autologous Peripheral Blood Stem Cell Transplantation in Patient with POEMS Syndrome. ( 29467805 )
2018
13
POEMS Syndrome: Diagnosis and Investigative Work-up. ( 29157614 )
2018
14
Necrotizing autoimmune myopathy associated with POEMS syndrome report. ( 29088446 )
2018
15
The Peripheral Neuropathies of POEMS Syndrome and Castleman Disease. ( 29157616 )
2018
16
A case report of POEMS syndrome with renal involvement as immunotactoid glomerulopathy. ( 29489695 )
2018
17
Cerebral pseudotumor as the first manifestation of POEMS syndrome: A case report. ( 29319491 )
2018
18
Daratumumab for POEMS Syndrome. ( 29622102 )
2018
19
A prospective phase II study of low dose lenalidomide plus dexamethasone in patients with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. ( 29603764 )
2018
20
Castleman disease of the hyaline vascular variant transforming to POEMS syndrome as endpoint: a case report. ( 30301456 )
2018
21
Successful treatment of newly diagnosed POEMS syndrome with reduced-dose bortezomib based regimen. ( 28146276 )
2018
22
POEMS Syndrome: Therapeutic Options. ( 29157615 )
2018
23
Clonal immunoglobulin λ light-chain gene rearrangements detected by next generation sequencing in POEMS syndrome. ( 30015379 )
2018
24
POEMS syndrome: diagnostic delay and successful treatment with lenalidomide, cyclophosphamide and prednisone followed by autologous peripheral stem cell transplantation. ( 30054320 )
2018
25
Serum vascular endothelial growth factor (VEGF) level can be used as a diagnostic marker in POEMS syndrome. ( 30082079 )
2018
26
POEMS syndrome. ( 30138145 )
2018
27
Impact of lenalidomide exposure on blood cell collection for autotransplants in persons with POEMS syndrome. ( 30154887 )
2018
28
Raised VEGF: High sensitivity and specificity in the diagnosis of POEMS syndrome. ( 30175160 )
2018
29
Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (POEMS) syndrome complicated by ischemic stroke: A case report. ( 30210737 )
2018
30
Prevalence and course of endocrinopathy in POEMS syndrome. ( 30239770 )
2018
31
An updates on the diagnosis and management of the polyneuropathy of POEMS syndrome. ( 30264176 )
2018
32
Proposal of new clinical diagnostic criteria for POEMS syndrome. ( 30279213 )
2018
33
POEMS syndrome complicated with multiple ischemic vascular events: case report and review of literature. ( 30310290 )
2018
34
Anti-BCMA CAR-T cells for treatment of plasma cell dyscrasia: case report on POEMS syndrome and multiple myeloma. ( 30348186 )
2018
35
Improvement of thyroid function in POEMS syndrome after combination therapy of lenalidomide and dexamethasone. ( 30407096 )
2018
36
POEMS syndrome: clinical update. ( 30498913 )
2018
37
Concurrent juxtapapillary hemorrage and optic disc edema as initial presentation of POEMS syndrome. ( 30503001 )
2018
38
Long-term durable efficacy of autologous stem cell transplantation in POEMS syndrome. ( 30548467 )
2018
39
Safety and Efficacy of Granulocyte Colony-Stimulating Factor Monotherapy for Peripheral Blood Stem Cell Collection in POEMS Syndrome. ( 27840209 )
2017
40
POEMS syndrome. ( 29279594 )
2017
41
Coexistence of Quasi-moyamoya Disease and POEMS Syndrome in a Patient with Intracranial Hemorrhage: A Case Report and Literature Review. ( 28664017 )
2017
42
Electrophysiologic features of POEMS syndrome compared with MGUS-related neuropathy. ( 28472865 )
2017
43
Ischemic stroke in patients with POEMS syndrome: a case report and comprehensive analysis of literature. ( 29179528 )
2017
44
POEMS syndrome: a rare cause of exudative ascites and chronic peripheral neuropathy. ( 28637843 )
2017
45
POEMS SYNDROME: an Update. ( 28894560 )
2017
46
Alcohol Misuse Link to POEMS Syndrome in a Patient. ( 28946631 )
2017
47
Autologous peripheral blood stem cell transplantation and the role of lenalidomide in patients affected by poems syndrome. ( 28913957 )
2017
48
Glomeruloid Hemangioma as a Marker for the Early Diagnosis of POEMS Syndrome. ( 28392663 )
2017
49
Plexogenic pulmonary hypertension associated with POEMS syndrome. ( 28856089 )
2017
50
POEMS syndrome in a patient with rheumatoid arthritis. ( 28775105 )
2017

Variations for Poems Syndrome

Expression for Poems Syndrome

Search GEO for disease gene expression data for Poems Syndrome.

Pathways for Poems Syndrome

Pathways related to Poems Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 EPO IL1B IL6 TNF VEGFA
2
Show member pathways
12.88 IL1B IL6 TNF VEGFA
3
Show member pathways
12.83 EPO IL6 TNF VEGFA
4
Show member pathways
12.71 IL1B IL6 TNF VEGFA
5
Show member pathways
12.44 IL1B IL6 TNF
6
Show member pathways
12.43 IL1B IL6 TNF
7
Show member pathways
12.28 IL1B IL6 TNF
8
Show member pathways
12.2 IL1B IL6 TNF
9
Show member pathways
12.2 IL1B IL6 TNF
10
Show member pathways
12.17 IL1B IL6 TNF
11
Show member pathways
12.11 IL1B IL6 TNF
12 12.1 IL1B IL6 TNF
13
Show member pathways
12.08 IL1B IL6 TNF
14
Show member pathways
12.07 IL1B IL6 TNF
15
Show member pathways
12.05 IL1B IL6 TNF
16 12.04 IL6 TNF VEGFA
17 11.96 IL1B TNF VEGFA
18 11.95 IL1B IL6 TNF VEGFA
19
Show member pathways
11.93 IL1B IL6 TNF
20
Show member pathways
11.91 IL1B IL6 TNF
21 11.88 IL1B IL6 TNF
22 11.86 EPO IL6 TNF
23 11.83 IL1B IL6 TNF
24 11.79 EPO IL6 VEGFA
25 11.76 IL1B IL6 TNF
26 11.73 IL1B IL6 TNF VEGFA
27 11.66 IL1B IL6 TNF
28 11.64 IL1B IL6 TNF
29 11.62 IL1B IL6 TNF VEGFA
30 11.61 IL1B IL6 TNF
31 11.54 EPO IL1B IL6 TNF
32 11.49 IL1B IL6 TNF
33 11.43 IL6 VEGFA
34 11.43 IL6 TNF
35 11.43 IL1B IL6 TNF
36 11.42 IL1B IL6 TNF
37 11.41 IL1B IL6 TNF VEGFA
38 11.4 IL6 TNF
39 11.4 TNF VEGFA
40 11.4 EPO IL6 VEGFA
41 11.39 IL1B TNF
42 11.39 IL1B TNF
43 11.39 EPO IL1B IL6
44 11.35 IL1B IL6 TNF
45
Show member pathways
11.34 IL1B TNF
46 11.28 EPO VEGFA
47 11.25 IL1B IL6
48 11.23 EPO VEGFA
49 11.23 IL1B IL6 TNF
50 11.21 IL1B IL6 TNF

GO Terms for Poems Syndrome

Cellular components related to Poems Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 EPO IL1B IL6 PTX3 TNF VEGFA
2 extracellular space GO:0005615 9.1 EPO IL1B IL6 PTX3 TNF VEGFA

Biological processes related to Poems Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.96 EPO IL1B IL6 TNF
2 positive regulation of cell proliferation GO:0008284 9.93 EPO IL1B IL6 VEGFA
3 positive regulation of gene expression GO:0010628 9.9 IL1B IL6 TNF VEGFA
4 inflammatory response GO:0006954 9.87 IL1B IL6 PTX3 TNF
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.86 EPO IL1B TNF
6 positive regulation of protein phosphorylation GO:0001934 9.84 IL1B TNF VEGFA
7 response to hypoxia GO:0001666 9.83 EPO IL1B VEGFA
8 cellular response to lipopolysaccharide GO:0071222 9.83 IL1B IL6 TNF
9 cytokine-mediated signaling pathway GO:0019221 9.8 IL1B IL6 TNF VEGFA
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.79 IL1B IL6 TNF
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.78 IL1B IL6 TNF
12 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.72 IL6 TNF VEGFA
13 positive regulation of cell adhesion GO:0045785 9.71 TNF VEGFA
14 negative regulation of fat cell differentiation GO:0045599 9.71 IL6 TNF
15 positive regulation of cell division GO:0051781 9.71 IL1B VEGFA
16 positive regulation of interferon-gamma production GO:0032729 9.7 IL1B TNF
17 embryo implantation GO:0007566 9.7 EPO IL1B
18 positive regulation of JUN kinase activity GO:0043507 9.7 IL1B TNF
19 protein kinase B signaling GO:0043491 9.7 IL1B TNF
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 EPO IL6 VEGFA
21 acute-phase response GO:0006953 9.69 EPO IL6
22 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.69 IL1B TNF
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.69 IL1B TNF
24 response to glucocorticoid GO:0051384 9.69 IL1B IL6 TNF
25 positive regulation of p38MAPK cascade GO:1900745 9.68 IL1B VEGFA
26 positive regulation of interleukin-8 production GO:0032757 9.68 IL1B TNF
27 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.68 EPO VEGFA
28 positive regulation of protein complex assembly GO:0031334 9.67 TNF VEGFA
29 positive regulation of chemokine production GO:0032722 9.67 IL6 TNF
30 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.66 IL1B VEGFA
31 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
32 regulation of signaling receptor activity GO:0010469 9.65 EPO IL1B IL6 TNF VEGFA
33 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 IL1B TNF
34 cardiac muscle fiber development GO:0048739 9.64 MYOM2 VEGFA
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IL1B TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL1B TNF
37 response to dexamethasone GO:0071548 9.61 EPO IL1B
38 positive regulation of interleukin-6 production GO:0032755 9.61 IL1B IL6 TNF
39 negative regulation of lipid storage GO:0010888 9.59 IL6 TNF
40 response to salt stress GO:0009651 9.58 EPO TNF
41 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IL1B TNF
42 regulation of establishment of endothelial barrier GO:1903140 9.56 IL1B TNF
43 positive regulation of fever generation GO:0031622 9.54 IL1B TNF
44 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 IL1B PTX3 TNF
45 positive regulation of phagocytosis GO:0050766 9.5 IL1B PTX3 TNF
46 chronic inflammatory response to antigenic stimulus GO:0002439 9.48 IL1B TNF
47 sequestering of triglyceride GO:0030730 9.46 IL1B TNF
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IL1B TNF
49 negative regulation of neurogenesis GO:0050768 9.33 IL1B IL6 TNF
50 positive regulation of glial cell proliferation GO:0060252 9.13 IL1B IL6 TNF

Molecular functions related to Poems Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 EPO IL1B IL6 TNF VEGFA

Sources for Poems Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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