MCID: PMS001
MIFTS: 63

Poems Syndrome

Categories: Rare diseases, Neuronal diseases, Blood diseases, Immune diseases, Skin diseases, Bone diseases

Aliases & Classifications for Poems Syndrome

MalaCards integrated aliases for Poems Syndrome:

Name: Poems Syndrome 12 76 53 59 55 44 15 73
Crow-Fukase Syndrome 53 59 37
Osteosclerotic Myeloma 59 73
Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, and Skin Changes Syndrome 53
Polyneuropathy-Endocrinopathy-Plasma Cell Dyscrasia Syndrome 59
Polyneuropathy Organomegaly 53
Takatsuki Syndrome 59
Pep Syndrome 59

Characteristics:

Orphanet epidemiological data:

59
poems syndrome
Age of onset: Adult,Elderly; Age of death: adult,elderly,normal life expectancy;

Classifications:



Summaries for Poems Syndrome

NIH Rare Diseases : 53 POEMS syndrome is a rare, mulitisystem disorder. POEMS stands for the disorder's features, which may include Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes. Signs and symptoms may include progressive sensorimotor polyneuropathy; enlarged liver, spleen, and/or lymph nodes; a disorder of the endocrine glands (often with multiple abnormalities); a monoclonal plasma cell proliferative disorder; and darkening of the skin (hyperpigmentation). Various other symptoms may also occur and may vary among affected people. The underlying cause of the disorder is not well understood. POEMS syndrome is a chronic disorder, with a median survival time of 8-14 years. There is no standard treatment; management depends on the underlying plasma cell disorder and may include radiation therapy, chemotherapy, and/or hematopoietic cell transplantation.

MalaCards based summary : Poems Syndrome, also known as crow-fukase syndrome, is related to glomeruloid hemangioma and macular retinal edema. An important gene associated with Poems Syndrome is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are TGF-Beta Pathway and PI3K-Akt signaling pathway. The drugs Lenalidomide and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and endothelial, and related phenotypes are polyneuropathy and hypogonadism

Wikipedia : 76 POEMS syndrome (also termed osteosclerotic myeloma, Crow–Fukase syndrome, Takatsuki disease, or PEP... more...

Related Diseases for Poems Syndrome

Diseases related to Poems Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 359)
# Related Disease Score Top Affiliating Genes
1 glomeruloid hemangioma 31.1 MYOM2 VEGFA
2 macular retinal edema 30.6 IL6 VEGFA
3 hematopoietic stem cell transplantation 30.2 IL6 TNF
4 pericardial effusion 30.0 IL6 VEGFA
5 plasma cell neoplasm 30.0 IL6 MYOM2
6 brucellosis 29.5 IL6 TNF
7 arthritis 29.2 IL1B IL6 TNF
8 osteosclerotic myeloma 29.1 IL1B IL6 MYOM2 TNF
9 rheumatoid arthritis 28.7 IL1B IL6 TNF VEGFA
10 myocardial infarction 28.7 IL1B IL6 TNF VEGFA
11 end stage renal failure 28.5 EPO IL6 TNF
12 myeloma, multiple 27.6 EPO IL6 MYOM2 TNF VEGFA
13 diabetes mellitus 27.1 EPO IL1B IL6 TNF VEGFA
14 spinal disease 10.6 IL6 VEGFA
15 primary effusion lymphoma 10.6 IL6 VEGFA
16 spindle cell sarcoma 10.6 IL6 VEGFA
17 central retinal vein occlusion 10.6 IL6 VEGFA
18 recurrent corneal erosion 10.6 IL1B IL6
19 bagassosis 10.6 IL1B IL6
20 periodontitis, chronic 10.6 IL1B IL6
21 uremic pruritus 10.5 IL1B IL6
22 funisitis 10.5 IL1B IL6
23 glossitis 10.5 IL1B IL6
24 euthyroid sick syndrome 10.5 IL1B IL6
25 ascaris lumbricoides infection 10.5 IL1B IL6
26 median neuropathy 10.5 MYOM2 VEGFA
27 dupuytren contracture 10.5 IL1B VEGFA
28 periapical periodontitis 10.5 IL1B IL6
29 pyogenic granuloma 10.5 ANGPT2 VEGFA
30 vaginal disease 10.5 IL1B IL6
31 endometrial disease 10.5 IL1B IL6
32 cysticercosis 10.5 IL1B IL6
33 background diabetic retinopathy 10.5 ANGPT2 VEGFA
34 vaginitis 10.5 IL1B IL6
35 primary amebic meningoencephalitis 10.5 IL1B IL6
36 lipodermatosclerosis 10.5 ANGPT2 VEGFA
37 hydrarthrosis 10.5 IL1B IL6
38 extramedullary plasmacytoma 10.5 IL6 MYOM2
39 polyclonal hypergammaglobulinemia 10.5 IL6 MYOM2
40 impetigo 10.5 IL6 MYOM2
41 gingival disease 10.4 IL1B IL6
42 macular holes 10.4 ANGPT2 VEGFA
43 intermittent claudication 10.4 IL6 VEGFA
44 polyneuropathy 10.4
45 retinal vein occlusion 10.4 IL6 VEGFA
46 necrotizing fasciitis 10.4 IL6 MYOM2
47 peripheral artery disease 10.4 IL6 VEGFA
48 arteriovenous malformation 10.4 IL6 VEGFA
49 scorpion envenomation 10.4 IL6 TNF
50 arteriovenous malformations of the brain 10.4 IL6 VEGFA

Graphical network of the top 20 diseases related to Poems Syndrome:



Diseases related to Poems Syndrome

Symptoms & Phenotypes for Poems Syndrome

Human phenotypes related to Poems Syndrome:

59 32 (show all 46)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 polyneuropathy 59 32 obligate (100%) Obligate (100%) HP:0001271
2 hypogonadism 59 32 hallmark (90%) Very frequent (99-80%) HP:0000135
3 visceromegaly 59 32 hallmark (90%) Very frequent (99-80%) HP:0003271
4 lymphoproliferative disorder 59 32 hallmark (90%) Very frequent (99-80%) HP:0005523
5 increased antibody level in blood 59 32 hallmark (90%) Very frequent (99-80%) HP:0010702
6 abnormality of skin physiology 59 32 hallmark (90%) Very frequent (99-80%) HP:0011122
7 gynecomastia 59 32 frequent (33%) Frequent (79-30%) HP:0000771
8 diabetes mellitus 59 32 frequent (33%) Frequent (79-30%) HP:0000819
9 hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0000821
10 hyperpigmentation of the skin 59 32 frequent (33%) Frequent (79-30%) HP:0000953
11 hypertrichosis 59 32 frequent (33%) Frequent (79-30%) HP:0000998
12 hemangioma 59 32 frequent (33%) Frequent (79-30%) HP:0001028
13 thickened skin 59 32 frequent (33%) Frequent (79-30%) HP:0001072
14 papilledema 59 32 frequent (33%) Frequent (79-30%) HP:0001085
15 areflexia 59 32 frequent (33%) Frequent (79-30%) HP:0001284
16 ascites 59 32 frequent (33%) Frequent (79-30%) HP:0001541
17 pericardial effusion 59 32 frequent (33%) Frequent (79-30%) HP:0001698
18 leukonychia 59 32 frequent (33%) Frequent (79-30%) HP:0001820
19 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
20 thrombocytosis 59 32 frequent (33%) Frequent (79-30%) HP:0001894
21 pulmonary arterial hypertension 59 32 frequent (33%) Frequent (79-30%) HP:0002092
22 pleural effusion 59 32 frequent (33%) Frequent (79-30%) HP:0002202
23 sclerosis of skull base 59 32 frequent (33%) Frequent (79-30%) HP:0002694
24 lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002716
25 paresthesia 59 32 frequent (33%) Frequent (79-30%) HP:0003401
26 sclerosis of hand bone 59 32 frequent (33%) Frequent (79-30%) HP:0004054
27 sclerotic vertebral endplates 59 32 frequent (33%) Frequent (79-30%) HP:0004576
28 metaphyseal sclerosis 59 32 frequent (33%) Frequent (79-30%) HP:0004979
29 primary adrenal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008207
30 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
31 pain 59 32 frequent (33%) Frequent (79-30%) HP:0012531
32 erectile abnormalities 59 32 frequent (33%) Frequent (79-30%) HP:0100639
33 clubbing of fingers 59 32 frequent (33%) Frequent (79-30%) HP:0100759
34 sclerosis of foot bone 59 32 frequent (33%) Frequent (79-30%) HP:0100925
35 prolactin excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000870
36 acrocyanosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001063
37 polycythemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001901
38 restrictive deficit on pulmonary function testing 59 32 occasional (7.5%) Occasional (29-5%) HP:0002111
39 respiratory insufficiency due to muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0002747
40 arterial thrombosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004420
41 venous thrombosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004936
42 lipodystrophy 59 32 occasional (7.5%) Occasional (29-5%) HP:0009125
43 hyperesthesia 59 32 occasional (7.5%) Occasional (29-5%) HP:0100963
44 abnormality of the endocrine system 59 Very frequent (99-80%)
45 edema 59 Frequent (79-30%)
46 muscle weakness 59 Frequent (79-30%)

MGI Mouse Phenotypes related to Poems Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 IL1B IL6 TNF VEGFA ANGPT2 EPO
2 immune system MP:0005387 9.73 EPO IL1B IL6 TNF VEGFA ANGPT2
3 integument MP:0010771 9.63 IL1B IL6 TNF VEGFA ANGPT2 EPO
4 neoplasm MP:0002006 9.26 IL1B IL6 TNF VEGFA
5 respiratory system MP:0005388 9.02 IL6 TNF VEGFA ANGPT2 EPO

Drugs & Therapeutics for Poems Syndrome

Drugs for Poems Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenalidomide Approved Phase 2 191732-72-6 216326
2
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
3 Ixazomib Approved, Investigational Phase 2 1072833-77-2
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
5
Glycine Approved, Nutraceutical, Vet_approved Phase 2 56-40-6 750
6 Dexamethasone acetate Phase 2 1177-87-3
7 glucocorticoids Phase 2
8
protease inhibitors Phase 2
9 Gastrointestinal Agents Phase 2
10 HIV Protease Inhibitors Phase 2
11 Hormone Antagonists Phase 2
12 Angiogenesis Inhibitors Phase 2
13 Hormones Phase 2
14 Angiogenesis Modulating Agents Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
16 Peripheral Nervous System Agents Phase 2
17 Anti-Bacterial Agents Phase 2
18 Immunosuppressive Agents Phase 2
19 Anti-Infective Agents Phase 2
20 Antiemetics Phase 2
21 Anti-Inflammatory Agents Phase 2
22 BB 1101 Phase 2
23 Autonomic Agents Phase 2
24 Antineoplastic Agents, Hormonal Phase 2
25 Chelating Agents Phase 2
26 Neurotransmitter Agents Phase 2
27 Anticoagulants Phase 2
28 Calcium, Dietary Phase 2
29 Citrate Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 POEMS Syndrome Treatment With Lenalidomide Unknown status NCT01639898 Phase 2 Lenalidomide and dexamethasone;Lenalidomide and dexamethasone
2 The Treatment of Lenalidomide in Patients With POEMS Syndrome Unknown status NCT00971685 Phase 2 Lenalidomide and dexamethasone
3 Study to Evaluate Lenalidomide Plus Dexamethasone in Patients With Newly Diagnosed POEMS Syndrome Completed NCT01816620 Phase 2 Lenalidomide, Dexamethasone
4 Efficacy and Safety of Lenalidomide as a Treatment for Recurrent or Refractory POEMS Syndrome Trial Completed NCT02193698 Phase 2 Lenalidomide+Dexamethasone
5 Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome Recruiting NCT02921893 Phase 2 Dexamethasone;Ixazomib Citrate;Lenalidomide

Search NIH Clinical Center for Poems Syndrome

Cochrane evidence based reviews: poems syndrome

Genetic Tests for Poems Syndrome

Anatomical Context for Poems Syndrome

MalaCards organs/tissues related to Poems Syndrome:

41
Skin, Lymph Node, Endothelial, Liver, Spleen, Bone, Testes

Publications for Poems Syndrome

Articles related to Poems Syndrome:

(show top 50) (show all 577)
# Title Authors Year
1
Cutaneous manifestations as a clue to the diagnosis of POEMS syndrome. ( 29921722 )
2018
2
What is the place of POEMS syndrome in the current classification of monoclonal gammopathies of renal significance? ( 29134615 )
2018
3
Hepatobiliary and Pancreatic: Obliterative portal venopathy found in Castleman disease variant of POEMS syndrome. ( 29691905 )
2018
4
Cutaneous Mycobacterium chelonae infection following autologous peripheral blood stem cell transplantation for POEMS syndrome. ( 29861185 )
2018
5
Atypical central retinal artery occlusion as the first presentation of POEMS syndrome: a case report. ( 29739345 )
2018
6
RETINAL MICROSTRUCTURE IN POEMS SYNDROME. ( 29547451 )
2018
7
Skull base plasmacytoma: A unique case of POEMS syndrome with a plasmacytoma causing craniocervical instability. ( 29100675 )
2018
8
An atypical presentation of POEMS syndrome with IgG kappa type M protein and normal VEGF level: Case report and review of literature. ( 29893339 )
2018
9
Long-term evaluation of physical improvement and survival of autologous stem cell transplantation in POEMS syndrome. ( 29599110 )
2018
10
The Efficacy and Long-Term Outcomes of Autologous Stem Cell Transplantation in POEMS Syndrome: a Nation-Wide Survey in Japan. ( 29409882 )
2018
11
Prognostic value of serum vascular endothelial growth factor and hematological responses in patients with newly-diagnosed POEMS syndrome. ( 29618787 )
2018
12
Reduction of Optic Disc Oedema by Bortezomib and Dexamethasone Followed by Autologous Peripheral Blood Stem Cell Transplantation in Patient with POEMS Syndrome. ( 29467805 )
2018
13
POEMS Syndrome: Diagnosis and Investigative Work-up. ( 29157614 )
2018
14
Necrotizing autoimmune myopathy associated with POEMS syndrome report. ( 29088446 )
2018
15
The Peripheral Neuropathies of POEMS Syndrome and Castleman Disease. ( 29157616 )
2018
16
A case report of POEMS syndrome with renal involvement as immunotactoid glomerulopathy. ( 29489695 )
2018
17
Cerebral pseudotumor as the first manifestation of POEMS syndrome: A case report. ( 29319491 )
2018
18
Daratumumab for POEMS Syndrome. ( 29622102 )
2018
19
A prospective phase II study of low dose lenalidomide plus dexamethasone in patients with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. ( 29603764 )
2018
20
POEMS Syndrome: Therapeutic Options. ( 29157615 )
2018
21
Safety and Efficacy of Granulocyte Colony-Stimulating Factor Monotherapy for Peripheral Blood Stem Cell Collection in POEMS Syndrome. ( 27840209 )
2017
22
POEMS syndrome. ( 29279594 )
2017
23
Coexistence of Quasi-moyamoya Disease and POEMS Syndrome in a Patient with Intracranial Hemorrhage: A Case Report and Literature Review. ( 28664017 )
2017
24
Electrophysiologic features of POEMS syndrome compared with MGUS-related neuropathy. ( 28472865 )
2017
25
Ischemic stroke in patients with POEMS syndrome: a case report and comprehensive analysis of literature. ( 29179528 )
2017
26
POEMS syndrome: a rare cause of exudative ascites and chronic peripheral neuropathy. ( 28637843 )
2017
27
POEMS SYNDROME: an Update. ( 28894560 )
2017
28
Alcohol Misuse Link to POEMS Syndrome in a Patient. ( 28946631 )
2017
29
Autologous peripheral blood stem cell transplantation and the role of lenalidomide in patients affected by poems syndrome. ( 28913957 )
2017
30
Glomeruloid Hemangioma as a Marker for the Early Diagnosis of POEMS Syndrome. ( 28392663 )
2017
31
Plexogenic pulmonary hypertension associated with POEMS syndrome. ( 28856089 )
2017
32
POEMS syndrome in a patient with rheumatoid arthritis. ( 28775105 )
2017
33
POEMS Syndrome with Biclonal Gammopathy: A Rare Association. ( 28893029 )
2017
34
Polyneuropathy as Novel Initial Manifestation in a Case of "Nonsecretory" POEMS Syndrome with SjAPgren's Syndrome. ( 28133484 )
2017
35
Portal hypertension as the initial manifestation of POEMS syndrome: a case report. ( 28503308 )
2017
36
Cerebral large-vessel vasculitis as an unusual manifestation of POEMS syndrome. ( 28432517 )
2017
37
As white as ivory: sclerotic vertebra in POEMS syndrome. ( 28589896 )
2017
38
Pseudo Symmer's Pipe-Stem Fibrosis in Idiopathic Noncirrhotic Portal Hypertension Associated with POEMS Syndrome. ( 28848769 )
2017
39
POEMS syndrome presentation with progressive weakness in upper and lower limbs: A case report. ( 29113155 )
2017
40
A rare cause of pericardial effusion and ascites: POEMS syndrome. ( 29333225 )
2017
41
Osteolytic-variant POEMS syndrome: an uncommon presentation of "osteosclerotic" myeloma. ( 28343327 )
2017
42
Endocrine perturbations in POEMS syndrome: Misunderstood features of a rare paraneoplastic syndrome. ( 28495325 )
2017
43
POEMS syndrome: An elusive diagnosis. ( 28699264 )
2017
44
Utility of osteosclerotic lesion biopsy in diagnosis of POEMS syndrome: A case report. ( 29019884 )
2017
45
Lenalidomide and dexamethasone in patients with POEMS syndrome: results of a prospective, open-label trial. ( 29048107 )
2017
46
An Adult with Polyneuropathy and Hypogonadism due to Poems Syndrome. ( 29056130 )
2017
47
Diagnostic challenges in POEMS syndrome presenting with polyneuropathy: A case series. ( 28566158 )
2017
48
Acquired blue sclerae in POEMS syndrome. ( 28419450 )
2017
49
POEMS syndrome: 2017 Update on diagnosis, risk stratification, and management. ( 28699668 )
2017
50
Kennedy Disease Misdiagnosed as Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome: A Case Report. ( 26618536 )
2016

Variations for Poems Syndrome

Expression for Poems Syndrome

Search GEO for disease gene expression data for Poems Syndrome.

Pathways for Poems Syndrome

Pathways related to Poems Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 ANGPT2 EPO IL1B IL6 TNF VEGFA
2
Show member pathways
12.82 ANGPT2 EPO IL6 TNF VEGFA
3
Show member pathways
12.73 IL1B IL6 TNF VEGFA
4 12.62 ANGPT2 IL1B TNF VEGFA
5
Show member pathways
12.51 EPO IL1B IL6 TNF
6
Show member pathways
12.47 ANGPT2 IL1B IL6 TNF
7
Show member pathways
12.45 ANGPT2 IL6 TNF VEGFA
8
Show member pathways
12.31 IL1B IL6 TNF
9
Show member pathways
12.29 IL1B IL6 TNF
10
Show member pathways
12.21 IL1B IL6 TNF
11
Show member pathways
12.21 IL1B IL6 TNF
12
Show member pathways
12.15 IL1B IL6 TNF
13
Show member pathways
12.14 IL1B IL6 TNF
14 12.11 IL1B IL6 TNF
15
Show member pathways
12.1 IL1B IL6 TNF
16
Show member pathways
12.09 IL1B IL6 TNF
17
Show member pathways
12.06 IL1B IL6 TNF
18 12.06 IL6 TNF VEGFA
19 11.98 IL1B TNF VEGFA
20 11.95 IL1B IL6 TNF VEGFA
21 11.91 IL1B IL6 TNF
22 11.89 EPO IL6 TNF
23 11.85 IL1B IL6 TNF
24 11.8 IL1B IL6 TNF
25 11.73 IL1B IL6 TNF VEGFA
26 11.68 IL1B IL6 TNF
27 11.66 IL1B IL6 TNF
28 11.62 ANGPT2 EPO IL6 VEGFA
29 11.58 IL1B IL6 TNF
30 11.55 IL1B IL6 TNF VEGFA
31 11.51 IL1B IL6 TNF
32 11.45 IL1B IL6 TNF
33 11.44 IL1B IL6 TNF
34 11.44 EPO IL1B IL6 TNF
35 11.43 IL6 VEGFA
36 11.43 IL6 TNF
37 11.42 EPO IL6 VEGFA
38 11.4 IL6 TNF
39 11.4 TNF VEGFA
40 11.4 IL1B TNF
41 11.4 EPO IL1B IL6
42 11.39 IL1B TNF
43 11.37 IL1B IL6 TNF
44
Show member pathways
11.35 IL1B TNF
45 11.27 ANGPT2 EPO VEGFA
46 11.25 IL1B IL6
47 11.24 EPO VEGFA
48 11.23 IL1B IL6 TNF
49 11.21 IL1B IL6 TNF
50 11.21 IL1B IL6 TNF VEGFA

GO Terms for Poems Syndrome

Cellular components related to Poems Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ANGPT2 EPO IL1B IL6 TNF VEGFA
2 extracellular space GO:0005615 9.1 ANGPT2 EPO IL1B IL6 TNF VEGFA

Biological processes related to Poems Syndrome according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.92 EPO IL1B IL6 TNF
2 positive regulation of cell proliferation GO:0008284 9.88 EPO IL1B IL6 VEGFA
3 leukocyte migration GO:0050900 9.81 ANGPT2 IL1B TNF
4 response to hypoxia GO:0001666 9.79 ANGPT2 EPO VEGFA
5 positive regulation of protein phosphorylation GO:0001934 9.78 IL1B TNF VEGFA
6 positive regulation of gene expression GO:0010628 9.78 IL1B IL6 TNF VEGFA
7 positive regulation of angiogenesis GO:0045766 9.76 ANGPT2 IL1B VEGFA
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.74 IL1B IL6 TNF
9 positive regulation of DNA binding transcription factor activity GO:0051091 9.71 IL1B IL6 TNF
10 cytokine-mediated signaling pathway GO:0019221 9.71 IL1B IL6 TNF VEGFA
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.69 IL1B TNF
12 positive regulation of cell adhesion GO:0045785 9.69 TNF VEGFA
13 positive regulation of cell division GO:0051781 9.68 IL1B VEGFA
14 negative regulation of fat cell differentiation GO:0045599 9.68 IL6 TNF
15 protein kinase B signaling GO:0043491 9.68 IL1B TNF
16 positive regulation of interferon-gamma production GO:0032729 9.68 IL1B TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 IL1B TNF
18 embryo implantation GO:0007566 9.67 EPO IL1B
19 acute-phase response GO:0006953 9.67 EPO IL6
20 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.66 IL1B TNF
21 positive regulation of phagocytosis GO:0050766 9.66 IL1B TNF
22 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.65 IL1B TNF
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 IL1B TNF
24 positive regulation of interleukin-8 production GO:0032757 9.65 IL1B TNF
25 positive regulation of p38MAPK cascade GO:1900745 9.64 IL1B VEGFA
26 positive regulation of protein complex assembly GO:0031334 9.63 TNF VEGFA
27 positive regulation of chemokine production GO:0032722 9.63 IL6 TNF
28 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.62 IL1B VEGFA
29 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.61 IL6 TNF VEGFA
30 negative regulation of lipid catabolic process GO:0050995 9.6 IL1B TNF
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 IL1B TNF
32 cardiac muscle fiber development GO:0048739 9.56 MYOM2 VEGFA
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.55 IL1B TNF
34 negative regulation of lipid storage GO:0010888 9.52 IL6 TNF
35 response to salt stress GO:0009651 9.51 EPO TNF
36 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.5 EPO IL6 VEGFA
37 positive regulation of chemokine biosynthetic process GO:0045080 9.49 IL1B TNF
38 regulation of establishment of endothelial barrier GO:1903140 9.46 IL1B TNF
39 positive regulation of fever generation GO:0031622 9.37 IL1B TNF
40 sequestering of triglyceride GO:0030730 9.26 IL1B TNF
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IL1B TNF
42 positive regulation of interleukin-6 production GO:0032755 9.13 IL1B IL6 TNF
43 regulation of signaling receptor activity GO:0010469 9.02 EPO IL1B IL6 TNF VEGFA

Molecular functions related to Poems Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 EPO IL1B IL6 TNF VEGFA

Sources for Poems Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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