Pollen Allergy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PLL012 MIFTS: 51	Pollen Allergy Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Pollen Allergy

MalaCards integrated aliases for Pollen Allergy:

Name: Pollen Allergy ¹² ¹⁵

Hay Fever ⁷³

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060497

UMLS ⁷³ C0018621

Sources

Summaries for Pollen Allergy

Disease Ontology : ¹² A respiratory allergy triggered by pollen.

MalaCards based summary : Pollen Allergy, also known as hay fever, is related to esophagitis, eosinophilic, 1 and rhinitis, and has symptoms including tinnitus, rhinorrhea and snoring. An important gene associated with Pollen Allergy is CD164 (CD164 Molecule), and among its related pathways/superpathways are Innate Immune System and Pathways in cancer. The drugs Montelukast and Cetirizine have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and eye, and related phenotypes are hematopoietic system and immune system

Wikipedia : ⁷⁶ Allergic rhinitis, also known as hay fever, is a type of inflammation in the nose which occurs when the... more...

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Related Diseases for Pollen Allergy

Diseases related to Pollen Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)

#	Related Disease	Score	Top Affiliating Genes
1	esophagitis, eosinophilic, 1	30.5	IL13 IL5
2	rhinitis	30.0	EPX ICAM1 IL13 IL4R IL5 RNASE3
3	respiratory allergy	29.9	IL13 IL3 IL4R IL5 RNASE3
4	food allergy	29.8	EPX FOXP3 IL13 IL5 RNASE3
5	allergic rhinitis	29.7	EPX ICAM1 IL13 IL4R IL5 MPO
6	allergic asthma	29.6	EPX IL13 IL4R IL5 RNASE3
7	asthma	29.0	ADRB2 EPX ICAM1 IL13 IL3 IL4R
8	timothy grass allergy	11.2
9	loeffler endocarditis	10.2	IL5 RNASE3
10	autoimmune enteropathy	10.2	FOXP3 ICAM1
11	cough variant asthma	10.2	IL5 RNASE3
12	cow milk allergy	10.2	IL5 RNASE3
13	milk allergy	10.2	IL5 RNASE3
14	esophagitis	10.2
15	cytokine deficiency	10.2	IL13 IL5
16	kimura disease	10.2	IL5 RNASE3
17	angioimmunoblastic lymphadenopathy with dysproteinemia	10.2	IL13 IL5
18	respiratory syncytial virus infectious disease	10.2	IL13 IL5
19	actinic prurigo	10.2	ICAM1 IL13
20	nickel allergic contact dermatitis	10.2	IL13 IL5
21	trichuriasis	10.2	IL13 RNASE3
22	nut allergy	10.2	FOXP3 IL5
23	drug allergy	10.2	IL4R IL5
24	seborrheic infantile dermatitis	10.2	IL3 IL5
25	angiostrongyliasis	10.2	IL13 IL5
26	strongyloidiasis	10.2	IL13 IL5
27	lichen disease	10.2	FOXP3 ICAM1
28	ascaris lumbricoides infection	10.2	IL13 IL5
29	eosinophilic meningitis	10.2	IL13 IL5
30	penicillin allergy	10.2	IL13 IL4R
31	hypereosinophilic syndrome, idiopathic	10.2	IL3 IL5
32	eosinophilic granuloma	10.2	EPX RNASE3
33	intestinal schistosomiasis	10.2	IL13 IL5
34	beta-lactam allergy	10.2	IL13 IL4R
35	chronic tic disorder	10.1	IL13 IL5
36	chronic eosinophilic pneumonia	10.1	ICAM1 IL5 RNASE3
37	conjunctival nevus	10.1	EPX RNASE3
38	wells syndrome	10.1	IL5 RNASE3
39	hepatitis	10.1
40	urticaria	10.1
41	enterobiasis	10.1	IL13 IL5
42	sinusitis	10.1	IL4R IL5 RNASE3
43	schistosomiasis	10.1	IL13 IL5 RNASE3
44	paragonimiasis	10.1	IL13 IL5 RNASE3
45	latex allergy	10.1	IL13 IL5 RNASE3
46	autoimmune disease of endocrine system	10.1	FOXP3 ICAM1
47	conjunctival disease	10.1	IL13 IL5 RNASE3
48	parasitic helminthiasis infectious disease	10.1	IL13 IL5 RNASE3
49	night blindness, congenital stationary, type 1a	10.1	IL13 IL5
50	lipoid nephrosis	10.1	IL13 IL4R

Graphical network of the top 20 diseases related to Pollen Allergy:

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Symptoms & Phenotypes for Pollen Allergy

UMLS symptoms related to Pollen Allergy:

tinnitus, rhinorrhea, snoring, coughing, sore throat, vertigo/dizziness, equilibration disorder

MGI Mouse Phenotypes related to Pollen Allergy:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.61	ADRB2 EPX FOXP3 ICAM1 IL13 IL4R
2	immune system	MP:0005387	9.28	ADRB2 EPX FOXP3 ICAM1 IL13 IL4R

Sources

Drugs & Therapeutics for Pollen Allergy

Drugs for Pollen Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 186)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Montelukast

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

158966-92-8

5281040

Cetirizine

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

83881-51-0

2678

Histamine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

51-45-6, 75614-87-8

774

Nitric Oxide

Approved

Phase 4

10102-43-9

145068

Fluticasone

Approved, Experimental

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

90566-53-3

62924

Azelastine

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

58581-89-8

2267

Pseudoephedrine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

90-82-4

7028

Xylometazoline

Approved, Investigational

Phase 4,Not Applicable

526-36-3

5709

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

5755

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

6741

mometasone furoate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

83919-23-7

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Ephedrine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

299-42-3

9294

Phenylephrine

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

59-42-7

6041

Oxymetazoline

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

1491-59-4

4636

Loratadine

Approved, Investigational

Phase 4,Phase 3,Phase 2

79794-75-5

3957

Levocetirizine

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

130018-77-8

1549000

Desloratadine

Approved, Investigational

Phase 4,Phase 3,Phase 2

100643-71-8

124087

Fexofenadine

Approved, Investigational

Phase 4,Phase 3,Phase 2

83799-24-0

3348

Diphenhydramine

Approved, Investigational

Phase 4

147-24-0, 58-73-1

3100

Promethazine

Approved, Investigational

Phase 4

60-87-7

4927

Epinastine

Approved, Investigational

Phase 4,Phase 3,Phase 2

80012-43-7

3241

Ergocalciferol

Approved, Nutraceutical

Phase 4

50-14-6

5280793

Vitamin D3

Approved, Nutraceutical

Phase 4

67-97-0

5280795 6221

Vitamin D

Approved, Nutraceutical, Vet_approved

Phase 4

1406-16-2

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

Tranilast

Investigational

Phase 4

53902-12-8

93543

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Not Applicable

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Not Applicable

Leukotriene Antagonists

Phase 4,Phase 3,Phase 2,Not Applicable

Histamine H1 Antagonists, Non-Sedating

Phase 4,Phase 3,Phase 2,Not Applicable

Anti-Allergic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Histamine Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Respiratory System Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Not Applicable

Histamine H1 Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Asthmatic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Histamine Phosphate

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

51-74-1

65513

Lipoxygenase Inhibitors

Phase 4,Phase 3,Phase 2,Not Applicable

Autonomic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Bronchodilator Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Dermatologic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Vasoconstrictor Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Nasal Decongestants

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antineoplastic Agents, Hormonal

Phase 4

Methylprednisolone acetate

Phase 4

Interventional clinical trials:

(show top 50) (show all 424)

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis	Unknown status	NCT00488176	Phase 4	montelukast;cetirizine;montelukast and cetirizine;placebo
2	POLlinosis and Exhaled Breath Temperature	Unknown status	NCT01785394	Phase 4	5 grass allergen extract
3	Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis	Unknown status	NCT02014623	Phase 4	Control
4	Evaluating Factors Involved in Dymista's Superior Clinical Efficacy to Fluticasone Propionate in the Treatment of Seasonal Allergic Rhinitis	Unknown status	NCT02402465	Phase 4	Placebo;Fluticasone propionate;Fluticasone/Azelastine nasal spray
5	4"S" - Seasonal Symptoms Suppression Study	Unknown status	NCT02557269	Phase 4	Xylometazoline - intranasal application;Azelastine - intranasal application;Mometasone furoate - intranasal application;Hydroxyl-propyl-methyl cellulose powder - intranasal application;Bilastine 20 mg;Prednisolone 5 mg
6	Can we Help People With the Oral Allergy Syndrome Eat Fresh Fruit?	Unknown status	NCT01431859	Phase 4
7	Fluticasone Furoate Treatment of Daytime Somnolence and Cognitive Performance in Seasonal Allergic Rhinitis	Completed	NCT00997620	Phase 4	Fluticasone furoate Nasal Spray 110 mcg;Placebo
8	Efficacy and Safety of Lectranal® in Treatment of Seasonal Allergic Rhinitis Symptoms	Completed	NCT00460538	Phase 4
9	Comparison of Olopatadine 0.6% and Fluticasone Proprionate 50mcg Nasal Sprays in a Two Week Seasonal Allergic Rhinitis Trial	Completed	NCT00691665	Phase 4	Olopatadine HCL Nasal Spray, 0.6%;Fluticasone Propionate Nasal Spray, 50 mcg
10	A Randomized, Placebo Controlled Study to Determine the Efficacy and Speed of a Nasal Spray in Allergen Induced Seasonal Allergic Rhinitis	Completed	NCT00561717	Phase 4	Azelastine and placebo;Loratadine and Placebo;Cetirizine and Placebo;Placebo and Placebo (spray and Tablet)
11	A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis	Completed	NCT00653224	Phase 4	levocetirizine dihydrochloride;placebo
12	A Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine in Adults With Seasonal Allergic Rhinitis	Completed	NCT00621959	Phase 4	levocetirizine dihydrochloride;placebo
13	Preference for Clarinex Tablets vs Allegra Tablets in Patients With Seasonal Allergies (P03178)	Completed	NCT00794768	Phase 4	desloratadine 5 mg;fexofenadine
14	Preference for Clarinex Tablets vs. Allegra Tablets in Patients With Seasonal Allergies (Study P03179)	Completed	NCT00794248	Phase 4	desloratadine 5 mg;fexofenadine
15	Preference for Clarinex Tablets vs. Allegra Tablets in Patients With Seasonal Allergies (Study P03177)	Completed	NCT00783133	Phase 4	Desloratadine 5 mg;fexofenadine
16	Single-Center, Double-Blind, Randomized , Parallel Study Comparing Onset of Action, Efficacy & Safety of a Single-Dose of Fexofenadine HCl 180 mg vs Montelukast Na 10 mg & Placebo in Treating Seasonal Allergic Rhinitis Subjects in an Allergen Exposure Unit	Completed	NCT00637611	Phase 4	Fexofenadine HCl
17	Mometasone Furoate on Sleep Disturbances in Subjects With Seasonal Allergic Rhinitis (Study P04608) (COMPLETED)	Completed	NCT00358527	Phase 4	Mometasone Furoate Nasal Spray (MFNS)
18	Efficacy and Safety of Desloratadine vs. Fexofenadine 180 mg. vs. Placebo for Treating Seasonal Allergic Rhinitis (SAR) (Study P04054)	Completed	NCT00783146	Phase 4	desloratadine;fexofenadine;placebo
19	Efficacy and Safety of Desloratadine vs. Fexofenadine 180 mg. vs. Placebo for Treating Seasonal Allergic Rhinitis (SAR)(Study P04053)(COMPLETED)	Completed	NCT00783211	Phase 4	desloratadine;fexofenadine;placebo
20	Comparison of the Effects of Desloratadine and Placebo in the Relief of Nasal Symptom Scores in Subjects With Seasonal Allergic Rhinitis to Cypress Pollen (Study P02836)	Completed	NCT00867191	Phase 4	Placebo;Desloratadine
21	This Study Contains an Active Drug Treatment Group With Mometasone Furoate Nasal Spray and a Placebo (Dummy) Treatment Group for Seasonal Allergic Rhinitis (SAR). (Study P05073)(COMPLETED)	Completed	NCT00491504	Phase 4	Mometasone Furoate Nasal Spray
22	Randomized, Double Blind, Parallel Group, Placebo Controlled, Multi-Center Study of the Efficacy and Safety of Cetirizine HCl Syrup vs. Loratadine Syrup vs. Placebo in Treatment of Children With Seasonal Allergic Rhinitis (SAR)	Completed	NCT02932774	Phase 4	Cetirizine;Loratadine
23	Comparison of Seasonal Allergic Rhinitis Treatment With 2 Antihistamines Used in Combination With Intranasal Corticosteroid	Completed	NCT00845195	Phase 4	Olopatadine HCl Nasal Spray, 0.6%;Azelastine HCl Nasal Spray, 0.1%
24	Vitamin D Plus Fluticasone Propionate	Completed	NCT01103934	Phase 4	Vitamin D3;Placebo;Fluticasone Propionate
25	Efficacy of 2LALERG (Homeopathic Drug) in Allergic Rhinitis Related to Grass Pollen	Completed	NCT02690935	Phase 4	2LALERG;Placebo
26	Study of Nasal Symptom Relief and Side Effects in Hayfever Patients Treated With Aerius (Desloratadine)(P03442)	Completed	NCT00805584	Phase 4	desloratadine
27	POPULAR (Preference Of Patient Using Levocetirizine in Allergic Rhinitis)	Completed	NCT00160537	Phase 4	Levocetirizine
28	A Study of Onset of Action of Loratadine and Fexofenadine in Participants With Seasonal Allergic Rhinitis (P08712)	Completed	NCT01469234	Phase 4	loratadine;fexofenadine;placebo to loratadine;placebo to fexofenadine
29	Compare the Efficacy of Levocetirizine and Montelukast to Placebo in Reducing Seasonal Allergic Rhinitis (SAR) Symptoms in Ragweed Sensitive Subjects	Completed	NCT00295022	Phase 4	Placebo;Montelukast;Levocetirizine
30	Effects of Sublingual Immunotherapy on Grasspollen Allergy	Completed	NCT00150514	Phase 4	Oralgen
31	A Comparator Study of Fluticasone Propionate Nasal Spray Verses (vs) Cetirizine in the Treatment of Seasonal Allergic Rhinitis	Completed	NCT01916226	Phase 4	FPNS;FPNS Placebo;Cetirizine;Cetirizine Placebo
32	To Determine if Diphenhydramine Works for Nasal Congestion at Two Different Doses	Completed	NCT00648973	Phase 4	Diphenhydramine 50 mg;Diphenhydramine 25 mg;Pseudoephedrine 120 mg
33	Comparison of Perennial and Preseasonal Subcutaneous Immunotherapy	Completed	NCT01555736	Phase 4	grass (80%) and rye (20%) pollens allergoids
34	Effectiveness Of Therapy With A Thermal Water Nasal Aerosol In Children With Seasonal Allergic Rhinitis	Completed	NCT01326247	Phase 4
35	Efficacy and Safety of Levocetirizine and Fexofenadine in Reducing Symptoms of Seasonal Allergic Rhinitis	Completed	NCT00542607	Phase 4	levocetirizine dihydrochloride
36	Study of the Effect of Fluticasone Furoate Nasal Spray on Spring Allergy Eye Symptoms	Completed	NCT00891436	Phase 4	Fluticasone furoate nasal spray;Placebo nasal spray
37	Allergic Rhinitis Changes the Sinus Microbiome	Completed	NCT01852513	Phase 4	QNASL;Placebo nasal spray
38	MP-AzeFlu Allergen Chamber - Onset of Action Study	Completed	NCT03004131	Phase 4	Azelastine hydrochloride + fluticasone propionate nasal spray;Placebos;fluticasone propionate nasal spray + loratadine
39	Effect of Veramyst and Olopatadine 0.2% Opthalmic Solution on Allergy Symptoms	Completed	NCT01007253	Phase 4	PL nasal spray;fluticasone furoate (FF);PL eye drops;olopatadine (OLO)
40	Intranasal Steroids and the Nasal Ocular Response	Completed	NCT00473915	Phase 4	fluticasone furoate
41	Single Center, Randomized, Double-Blind,Crossover Study Comparing Effects Of Single-Dose Fexofenadine HCl 180 mg, Cetirizine 10 mg, and Placebo on Cognitive Performance in Naval Flight Personnel	Completed	NCT00637455	Phase 4	fexofenadine HCl
42	Regulatory Lymphocytes in Patients Treated With Specific Immunotherapy	Completed	NCT01475188	Phase 4	Allergovit
43	Comparator Study Evaluating Patient Preference Of FFNS vs. FPNS	Completed	NCT00539006	Phase 4	FPNS;FFNS;placebo FPNS;placebo FFNS
44	Comparator Study Evaluating Patient Experience And Preference Of FFNS vs. FPNS	Completed	NCT00519636	Phase 4	FPNS;FFNS;placebo FFNS;placebo FPNS
45	Tolerability of Grazax in Patients With Hayfever in Real Life Settings	Completed	NCT01433510	Phase 4	Grazax
46	Efficacy Investigation Study of Olopatadine Hydrochloride Ophthalmic Solution Using OHIO Chamber in Patients With Seasonal Allergic Rhinitis (SAR)	Completed	NCT00818805	Phase 4	Olopatadine 0.1%;Tranilast 0.5%;Placebo (Olopatadine);Placebo (Tranilast)
47	Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine	Completed	NCT00502775	Phase 4	fluticasone furoate, fexofenadine
48	Effects of Hypertonic Saline Solution (NACL 3%+NAHCO3) on Nasal Inflammation in Children With AR. RinASol- Pilot Study	Completed	NCT02729012	Phase 4	hypertonic saline solution (NACL 3%+NAHCO3)
49	Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine	Completed	NCT00435461	Phase 4	Fluticasone furoate and fexofenadine
50	Study Of Patients With Allergic Rhinitis And Asthma	Completed	NCT00296530	Phase 4	fluticasone propionate/salmeterol;fluticasone propionate;montelukast

Search NIH Clinical Center for Pollen Allergy

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

desloratadine

levocetirizine

levocetirizine dihydrochloride

Sources

Genetic Tests for Pollen Allergy

Sources

Anatomical Context for Pollen Allergy

MalaCards organs/tissues related to Pollen Allergy:

⁴¹

Skin, Testes, Eye, T Cells, Bone, B Cells, Lung

Sources

Publications for Pollen Allergy

Articles related to Pollen Allergy:

(show top 50) (show all 1148)

#	Title	Authors	Year
1	Long-term effect of monophosphoryl lipid A adjuvanted specific immunotherapy in patients with grass pollen allergy. ( 29562801 )	Zielen S....Rosewich M.	2018
2	Thunderstorm asthma: controlling (deadly) grass pollen allergy. ( 29437642 )	Davies J.M....Hew M.	2018
3	Impacts of long-term ragweed pollen load and other potential risk factors on ragweed pollen allergy among schoolchildren in Hungary. ( 29936806 )	VAPrAPs K....PA!ldy A.	2018
4	Cypress pollen allergy is responsible for two distinct phenotypes of allergic rhinitis different from other pollinosis. ( 29350019 )		2018
5	Ragweed Pollen Allergy: Burden, Characteristics, and Management of an Imported Allergen Source in Europe. ( 29788026 )		2018
6	Lolium perenne peptides for treatment of grass pollen allergy: AA randomized, double-blind, placebo-controlled clinical trial. ( 29030102 )		2018
7	Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization. ( 30155917 )	Gao Z...van Ree R	2018
8	Tell me about your hay fever: a qualitative investigation of allergic rhinitis management from the perspective of the patient. ( 29362452 )	Cvetkovski B...Bosnic-Anticevich S	2018
9	Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort. ( 30147342 )	Owens L...Le Sou?f PN	2018
10	Erratum: "Climate Change and Future Pollen Allergy in Europe". ( 30007904 )	Lake IR...Epstein MM	2018
11	Intralymphatic allergen immunotherapy against pollen allergy: A 3-year open follow-up study of 10 patients. ( 30021119 )	Ahlbeck L...Jenmalm MC	2018
12	A new molecular multiplex IgE assay for the diagnosis of pollen allergy in Mediterranean countries: A validation study. ( 30176088 )	Di Fraia M...Matricardi PM	2018
13	Component resolved analysis of ash pollen allergy in Bavaria. ( 30455718 )	Eder K...Gr?ger M	2018
14	Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization. ( 28675761 )	Skaaby T...Linneberg A	2018
15	Breast-feeding and risk of asthma, hay fever, and eczema. ( 29132959 )	Ek WE...Johansson ?	2018
16	Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma: a Mendelian randomization meta-analysis. ( 29249824 )	Skaaby T...Linneberg A	2018
17	Comparison of the immunogenicity of BM32, a recombinant hypoallergenic B cell epitope-based grass pollen allergy vaccine with allergen extract-based vaccines. ( 28576673 )	Weber M....Focke-Tejkl M.	2017
18	Management of Grass Pollen Allergy with 5-Grass Pollen Tablet: Results of a 2-Year Real-Life Study. ( 28455783 )	Shah-Hosseini K....MAPsges R.	2017
19	Efficacy of a leukotriene receptor antagonist for pediatric cedar pollen allergy complicated by asthma. ( 28928804 )	Yoshihara S....Arisaka O.	2017
20	Results from the 5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy. ( 28689794 )	Valovirta E....Klink R.	2017
21	Natural protective immunity against grass pollen allergy is maintained byA a diverse spectrum of response types. ( 28867457 )	Kurtaj A....Weiss R.	2017
22	The current overuse and misuse of meta-analyses on sublingual immunotherapy: the case of grass pollen allergy. ( 27922912 )		2017
23	Association of eosinophilic esophagitis and food pollen allergy syndrome. ( 27856094 )		2017
24	Involvement of cross-reactive carbohydrate determinants-specific IgE in pollen allergy testing. ( 28154803 )		2017
25	Association Between Hay Fever and High Myopia in United States Adolescents and Adults. ( 26974535 )	Shafer BM...Shields CL	2017
26	Patching it together: epicutaneous vaccination with heat-labile Escherichia coli toxin against birch pollen allergy. ( 27716934 )	Killingbeck SS...Haczku A	2017
27	Thumb-sucking or nail-biting in childhood led to a reduction in atopic sensitisation but not asthma or hay fever. ( 27756755 )	Roked F...North J	2017
28	Exposure to Extreme Heat Events Is Associated with Increased Hay Fever Prevalence among Nationally Representative Sample of US Adults: 1997-2013. ( 27840238 )	Upperman CR...Sapkota A	2017
29	Age at onset and persistence of eczema are related to subsequent risk of asthma and hay fever from birth to 18 years of age. ( 28301056 )	Lowe AJ...Dharmage SC	2017
30	The Influence of Asthma and/or Hay Fever on Pregnancy: Data from the 1995 National Survey of Family Growth. ( 28550983 )	Turkeltaub PC...Lockey RF	2017
31	Prenatal exposure to polychlorinated biphenyls and asthma, eczema/hay fever, and frequent ear infections. ( 29211547 )	Parker-Lalomio M...Persky VW	2017
32	Register-based observational studies - who will endorse that maternal smoking lowers the odds for developing hay fever and eczema? ( 29744202 )	Jokstad A	2017
33	Molecular cloning of plane pollen allergen PlaA aA 3 and its utility as diagnostic marker for peach associated plane pollen allergy. ( 26892183 )	Wangorsch A....Scheurer S.	2016
34	Efficacy and effectiveness of sublingual immunotherapy for grass pollen allergy: Reply to the letter of Marcucci F. ( 26778720 )	Salvatore C.	2016
35	Climate Change and Future Pollen Allergy in Europe. ( 27557093 )	Lake I.R....Epstein M.M.	2016
36	Biological Effects of Cloth Containing Specific Ore Powder in Patients with Pollen Allergy. ( 27660220 )	Lee S....Otsuki T.	2016
37	Immunotherapy With the PreS-based Grass Pollen Allergy Vaccine BM32 Induces Antibody Responses Protecting Against Hepatitis B Infection. ( 27568223 )	Cornelius C....Valenta R.	2016
38	Persistence of the IgE repertoire in birch pollen allergy. ( 27001158 )	Otte M....Voehringer D.	2016
39	Mould and grass pollen allergy as risk factors for childhood asthma in Zaragoza, Spain. ( 27255475 )	Segura N....ColA!s C.	2016
40	Urtica dioica pollen allergy: Clinical, biological, and allergomics analysis. ( 27788883 )	Tiotiu A....Poncet P.	2016
41	Pollen information consumption as an indicator of pollen allergy burden. ( 26373744 )		2016
42	A biology-driven receptor model for daily pollen allergy risk in Korea based on Weibull probability density function. ( 27387542 )		2016
43	Efficacy and effectiveness of sublingual immunotherapy for grass pollen allergy. ( 27012472 )		2016
44	Relevance of a 5-grass sublingual tablet for immunotherapy of patients with grass pollen allergy in North America. ( 26813047 )		2016
45	Mechanisms, safety and efficacy of a B cell epitope-based vaccine for immunotherapy of grass pollen allergy. ( 27650868 )		2016
46	The Smartphone: A Novel Diagnostic Tool in Pollen Allergy? ( 27326995 )		2016
47	Oocyst-Derived Extract of Toxoplasma Gondii Serves as Potent Immunomodulator in a Mouse Model of Birch Pollen Allergy. ( 27149118 )		2016
48	Hay fever in childhood, traits Neuroticism and Conscientiousness as independent predictors of the occurrence of hay fever in adulthood. ( 25836333 )	Cheng H...Furnham A	2016
49	Early farm residency and prevalence of asthma and hay fever in adults. ( 26377166 )	Rennie DC...Saskatchewan Rural Cohort Study Group	2016
50	Hay fever & homeopathy: a case series evaluation. ( 27211328 )	Pandey V	2016

Sources

Genes for Pollen Allergy

Genes related to Pollen Allergy (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CD164	CD164 Molecule	Protein Coding	22.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	RNASE3	Ribonuclease A Family Member 3	Protein Coding	22.03	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	IL5	Interleukin 5	Protein Coding	21.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	FOXP3	Forkhead Box P3	Protein Coding	21.76	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	IL4R	Interleukin 4 Receptor	Protein Coding	21.76	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	21.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	IL13	Interleukin 13	Protein Coding	21.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	IL3	Interleukin 3	Protein Coding	20.47	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	EPX	Eosinophil Peroxidase	Protein Coding	16.81	GeneCards inferred via : Publications (show sections)
10	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	16.81	GeneCards inferred via : Publications (show sections)
11	MPO	Myeloperoxidase	Protein Coding	16.81	GeneCards inferred via : Publications (show sections)
12	ADRB2	Adrenoceptor Beta 2	Protein Coding	16.81	GeneCards inferred via : Publications (show sections)

Sources

Variations for Pollen Allergy

Sources

Expression for Pollen Allergy

Search GEO for disease gene expression data for Pollen Allergy.

Sources

Pathways for Pollen Allergy

Pathways related to Pollen Allergy according to GeneCards Suite gene sharing:

(show all 20)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.77	EPX ICAM1 IL13 IL3 IL4R IL5
2	Pathways in cancer ³⁷	12.58	IL13 IL3 IL4R IL5
3	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.32	FOXP3 IL13 IL4R IL5
4	JAK-STAT signaling pathway (KEGG) ³⁷ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵	12.1	IL13 IL3 IL4R IL5
5	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	11.96	EPX FOXP3 ICAM1 IL13 IL3 IL4R
6	G beta-gamma signalling through PI3Kgamma ⁶⁶ Show member pathways G-protein beta-gamma signalling ⁶⁶ GPVI-mediated activation cascade ⁶⁶	11.9	IL3 IL5 PIK3CG
7	MAPK Pathway ⁷² Show member pathways Toll-like Receptor Pathway ⁷²	11.78	IL13 IL5 PIK3CG
8	Interleukin-4 and 13 signaling ⁶⁶	11.73	ICAM1 IL13 IL4R
9	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.73	ICAM1 IL13 IL3 IL4R IL5
10	Hematopoietic cell lineage ³⁷	11.62	IL3 IL4R IL5
11	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.52	CD164 IL3 IL5 MPO
12	Glucocorticoid receptor regulatory network ¹	11.49	ICAM1 IL13 IL5
13	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.43	FOXP3 IL3 IL5
14	Inflammatory Response Pathway ¹	11.11	IL4R IL5
15	Development and heterogeneity of the ILC family ¹	11.09	IL13 IL5
16	G-protein signaling_RhoB regulation pathway ²²	10.97	IL13 IL3 IL5
17	OX40 Pathway ⁶⁴	10.96	IL13 IL5
18	Th2 Differentiation Pathway ⁶⁵	10.92	FOXP3 IL13 IL4R IL5
19	Cytokines and Inflammatory Response ¹	10.9	IL13 IL3 IL5
20	LDL Oxidation in Atherogenesis ⁶⁴	10.73	ICAM1 MPO

Sources

GO Terms for Pollen Allergy

Cellular components related to Pollen Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.56	CD164 EPX IL13 IL3 IL4R IL5
2	extracellular space	GO:0005615	9.23	EPX ICAM1 IL13 IL3 IL4R IL5

Biological processes related to Pollen Allergy according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	response to lipopolysaccharide	GO:0032496	9.69	ICAM1 IL13 MPO
2	positive regulation of cold-induced thermogenesis	GO:0120162	9.61	ADRB2 IL13 IL4R
3	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.58	ICAM1 IL3 IL5
4	negative regulation of endothelial cell apoptotic process	GO:2000352	9.55	ICAM1 IL13
5	immune response	GO:0006955	9.55	CD164 IL13 IL3 IL4R IL5
6	cytokine production	GO:0001816	9.54	FOXP3 PIK3CG
7	hydrogen peroxide catabolic process	GO:0042744	9.52	EPX MPO
8	positive regulation of interleukin-4 production	GO:0032753	9.49	EPX FOXP3
9	positive regulation of macrophage activation	GO:0043032	9.48	IL13 IL4R
10	negative regulation of interleukin-10 production	GO:0032693	9.46	EPX FOXP3
11	positive regulation of mast cell degranulation	GO:0043306	9.37	IL13 IL4R
12	positive regulation of immunoglobulin production	GO:0002639	9.32	IL13 IL4R
13	negative regulation of interleukin-5 production	GO:0032714	9.26	EPX FOXP3
14	cytokine-mediated signaling pathway	GO:0019221	9.02	ICAM1 IL13 IL3 IL4R IL5
15	respiratory burst involved in defense response	GO:0002679	8.96	MPO PIK3CG

Molecular functions related to Pollen Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.13	IL13 IL3 IL5
2	peroxidase activity	GO:0004601	8.62	EPX MPO

Sources

Sources for Pollen Allergy

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Pollen Allergy

Aliases & Classifications for Pollen Allergy

MalaCards integrated aliases for Pollen Allergy:

Classifications:

External Ids:

Summaries for Pollen Allergy

Related Diseases for Pollen Allergy

Diseases related to Pollen Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Pollen Allergy:

Symptoms & Phenotypes for Pollen Allergy

UMLS symptoms related to Pollen Allergy:

MGI Mouse Phenotypes related to Pollen Allergy:

Drugs & Therapeutics for Pollen Allergy

Drugs for Pollen Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Genetic Tests for Pollen Allergy

Anatomical Context for Pollen Allergy

MalaCards organs/tissues related to Pollen Allergy:

Publications for Pollen Allergy

Articles related to Pollen Allergy:

Genes for Pollen Allergy

Genes related to Pollen Allergy (0 elite genes):

Variations for Pollen Allergy

Expression for Pollen Allergy

Pathways for Pollen Allergy

Pathways related to Pollen Allergy according to GeneCards Suite gene sharing:

GO Terms for Pollen Allergy

Cellular components related to Pollen Allergy according to GeneCards Suite gene sharing:

Biological processes related to Pollen Allergy according to GeneCards Suite gene sharing:

Molecular functions related to Pollen Allergy according to GeneCards Suite gene sharing:

Sources for Pollen Allergy

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :