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MCID: PLY187
MIFTS: 39

Polyarticular Juvenile Idiopathic Arthritis

Categories: Bone diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Polyarticular Juvenile Idiopathic Arthritis

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MalaCards integrated aliases for Polyarticular Juvenile Idiopathic Arthritis:

Name: Polyarticular Juvenile Idiopathic Arthritis 58 17
Juvenile Polyarthritis 58 32
Juvenile Polyarticular Arthritis 58
Polyarticular Jia 58

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Rare respiratory diseases
Rare systemic and rhumatological diseases


External Ids:

ICD10 32 M08.3
UMLS via Orphanet 72 C0409667
Orphanet 58 ORPHA404580
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Summaries for Polyarticular Juvenile Idiopathic Arthritis

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MalaCards based summary : Polyarticular Juvenile Idiopathic Arthritis, also known as juvenile polyarthritis, is related to crohn's disease and pericarditis. An important gene associated with Polyarticular Juvenile Idiopathic Arthritis is BTK (Bruton Tyrosine Kinase), and among its related pathways/superpathways are IL-2 Pathway and Measles. The drugs Prednisolone and Naltrexone have been mentioned in the context of this disorder. Affiliated tissues include t cells, whole blood and thymus, and related phenotypes are hematopoietic system and immune system

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Related Diseases for Polyarticular Juvenile Idiopathic Arthritis

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Diseases in the Polyarticular Juvenile Idiopathic Arthritis family:

Polyarticular Onset Juvenile Idiopathic Arthritis

Diseases related to Polyarticular Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 crohn's disease 29.7 TNF LACC1 IFNG
2 pericarditis 29.5 TNF IFNG
3 rheumatoid factor-positive polyarticular juvenile idiopathic arthritis 11.7
4 juvenile rheumatoid arthritis 11.6
5 rheumatoid factor-negative polyarticular juvenile idiopathic arthritis 11.6
6 multicentric carpotarsal osteolysis syndrome 11.4
7 polyarticular onset juvenile idiopathic arthritis 11.3
8 arteritis, familial granulomatous, with juvenile polyarthritis 11.1
9 arthritis 11.0
10 juvenile arthritis 10.7
11 uveitis 10.4
12 rheumatoid arthritis 10.3
13 agammaglobulinemia, x-linked 10.3
14 enthesopathy 10.3
15 agammaglobulinemia 10.3
16 arthropathy 10.3
17 macrophage activation syndrome 10.3
18 pneumocystosis 10.2 TNF BTK
19 plasma protein metabolism disease 10.2 TNF BTK
20 pyoderma 10.2 TNF BTK
21 systemic onset juvenile idiopathic arthritis 10.1 TNF LACC1
22 autoimmune disease 10.1
23 torticollis 10.1
24 progressive pseudorheumatoid dysplasia 10.1
25 multicentric osteolysis, nodulosis, and arthropathy 10.1
26 proteinuria, chronic benign 10.1
27 autosomal recessive disease 10.1
28 non-alcoholic fatty liver disease 10.1
29 nasopharyngitis 10.1
30 plica syndrome 10.1
31 toxic shock syndrome 10.1
32 ventricular septal defect 10.1
33 heart septal defect 10.1
34 ankylosis 10.1
35 synovitis 10.1
36 demyelinating disease 10.1
37 pustulosis of palm and sole 10.1
38 pneumonia 10.1
39 congestive heart failure 10.1
40 fibromyalgia 10.1
41 double outlet right ventricle 10.1
42 psoriasis 10.1
43 iridocyclitis 10.1
44 fatty liver disease 10.1
45 spondylarthropathy 10.1
46 oligoarticular juvenile idiopathic arthritis 10.1
47 b cell deficiency 10.1 TNF BTK
48 aortic valve insufficiency 10.0
49 enthesitis-related juvenile idiopathic arthritis 10.0
50 baylisascariasis 10.0 IFNG BTK

Graphical network of the top 20 diseases related to Polyarticular Juvenile Idiopathic Arthritis:



Diseases related to Polyarticular Juvenile Idiopathic Arthritis
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Symptoms & Phenotypes for Polyarticular Juvenile Idiopathic Arthritis

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MGI Mouse Phenotypes related to Polyarticular Juvenile Idiopathic Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 BTK CNDP2 CNR2 IFNG LACC1 TNF
2 immune system MP:0005387 9.43 BTK CNDP2 CNR2 IFNG LACC1 TNF
3 integument MP:0010771 9.02 BTK CNDP2 CNR2 IFNG TNF
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Drugs & Therapeutics for Polyarticular Juvenile Idiopathic Arthritis

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Drugs for Polyarticular Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
2
Naltrexone Approved, Investigational, Vet_approved Phase 3 16590-41-3 5360515
3
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
4
Sulfasalazine Approved Phase 3 599-79-1 5353980 5359476
5 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
6
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
7
Infliximab Approved Phase 3 170277-31-3
8
Hydroxychloroquine Approved Phase 3 118-42-3 3652
9
Ethanol Approved Phase 3 64-17-5 702
10
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
11
Etanercept Approved, Investigational Phase 3 185243-69-0
12
Adalimumab Approved, Experimental Phase 3 331731-18-1 16219006
13
Abatacept Approved Phase 3 332348-12-6 10237
14
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
15
tannic acid Approved Phase 3 1401-55-4
16
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
17
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
18
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
19
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
20 Antibodies, Monoclonal Phase 3
21 Narcotics Phase 3
22 Methylprednisolone Acetate Phase 3
23 Anti-Infective Agents Phase 3
24 Narcotic Antagonists Phase 3
25 Anti-Inflammatory Agents Phase 3
26 Analgesics, Non-Narcotic Phase 3
27 Gastrointestinal Agents Phase 3
28 Anti-Inflammatory Agents, Non-Steroidal Phase 3
29 Analgesics Phase 3
30 Rheumatoid Factor Phase 3
31 Immunosuppressive Agents Phase 3
32 Immunologic Factors Phase 3
33 Antirheumatic Agents Phase 3
34 Folic Acid Antagonists Phase 3
35 Vitamin B Complex Phase 3
36 Immunoglobulins Phase 3
37 Antimetabolites Phase 3
38 Antibodies Phase 3
39 Dermatologic Agents Phase 3
40 Vitamin B9 Phase 3
41 Folate Phase 3
42
Tyrosine Approved, Investigational, Nutraceutical Phase 1 60-18-4 6057

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 An Open-label, Extension, Phase III Study to Evaluate the Long-term Safety, Efficacy and PK of MRA in Patients With pJIA Who Participated in Study MRA318JP Completed NCT00144625 Phase 3 MRA(Tocilizumab)
2 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Efficacy, and Pharmacokinetics of the Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Idiopathic Arthritis Completed NCT00048542 Phase 3 OLE BSA Adalimumab +/- MTX;OLE FD Adalimumab +/- MTX
3 Comparison of Anti-TNF Therapy Plus Methotrexate, Combination Therapy of DMARDs, and Methotrexate Alone in Very Early Polyarticular Juvenile Idiopathic Arthritis. A National Randomized Multicenter Clinical Trial. Completed NCT01015547 Phase 3 Infliximab plus methotrexate;Combination of DMARDs;Methotrexate alone
4 A Phase 3 Multi-center, Open-Label Study to Evaluate Pharmacokinetics, Efficacy and Safety of Abatacept Administered Subcutaneously (SC) in Children and Adolescents With Active Polyarticular Juvenile Idiopathic Arthritis (pJIA) and Inadequate Response (IR) to Biologic or Non Biologic Disease Modifying Anti-rheumatic Drugs (DMARDs) Active, not recruiting NCT01844518 Phase 3
5 Treatment Tapering in Oligoarticular or Rheumatoid Factor Negative Polyarticular Juvenile Idiopathic Arthritis With Inactive Disease on Biologic Therapy Active, not recruiting NCT02840175 Phase 3 etanercept;adalimumab;Abatacept;Tocilizumab
6 A Multicenter, Double-Blind, Randomized-Withdrawal Trial of Subcutaneous Golimumab, a Humanized Anti-TNFa Antibody, in Subjects With Active Polyarticular Juvenile Idiopathic Arthritis (JIA) Despite Standard Therapy Terminated NCT01230827 Phase 3 CNTO 148 (Golimumab);Placebo;Methotrexate
7 A Phase Ib, Open-Label, Multicenter Study to Investigate the Pharmacokinetics, Pharmacodynamics, and Safety of Tocilizumab Following Subcutaneous Administration to Patients With Polyarticular Juvenile Idiopathic Arthritis Completed NCT01904279 Phase 1 Tocilizumab
8 Phase I Study of Itacitinib in Combination With Tocilizumab for the Treatment of Steroid Refractory Acute Graft Versus Host Disease Recruiting NCT04070781 Phase 1 Itacitinib;Tocilizumab
9 Enbrel-JIA Use Results Survey [All-Case Surveillance] Completed NCT01145352 Etanercept (genetical recombination)
10 Post-Marketing Surveillance of Humira Injection in Korean JIA Patients Under the New-Drug Re-examination Completed NCT02141984
11 Start Time Optimization of Biologics in Polyarticular JIA Completed NCT02593006

Search NIH Clinical Center for Polyarticular Juvenile Idiopathic Arthritis

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Genetic Tests for Polyarticular Juvenile Idiopathic Arthritis

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Anatomical Context for Polyarticular Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Polyarticular Juvenile Idiopathic Arthritis:

40
T Cells, Whole Blood, Thymus, B Cells, Endothelial
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Publications for Polyarticular Juvenile Idiopathic Arthritis

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Articles related to Polyarticular Juvenile Idiopathic Arthritis:

(show top 50) (show all 205)
# Title Authors PMID Year
1
Low Incidence of Inflammatory Bowel Disease Adverse Events in Adalimumab Clinical Trials Across Nine Different Diseases. 61
32100944 2021
2
A novel loss-of-function mutation in LACC1 underlies hereditary juvenile arthritis with extended intra-familial phenotypic heterogeneity. 61
33493343 2021
3
Subcutaneous dosing regimens of tocilizumab in children with systemic or polyarticular juvenile idiopathic arthritis. 61
33506875 2021
4
Concentration of survivin in children with oligo- and polyarticular juvenile idiopathic arthritis (JIA): diagnostic and prognostic value-a single-center study. 61
33494811 2021
5
Open-Label Phase 3 Study of Intravenous Golimumab in Patients With Polyarticular Juvenile Idiopathic Arthritis. 61
33493312 2021
6
Impact of core stability exercises on bone mineralization and functional capacity in children with polyarticular juvenile idiopathic arthritis: a randomized clinical trial. 61
32514677 2021
7
Model-Based Selection and Recommendation for Subcutaneous Abatacept Dose in Patients With Polyarticular Juvenile Idiopathic Arthritis. 61
33284480 2020
8
Fallen, But Not Forgotten: Atlantoaxial Dislocation in a Child With Polyarticular Juvenile Idiopathic Arthritis in the Era of Biologics. 61
33252396 2020
9
Longitudinal assessment of racial disparities in juvenile idiopathic arthritis disease activity in a treat-to-target intervention. 61
33187519 2020
10
Coexistence of a novel WISP3 pathogenic variant and an MEFV mutation in an Arabic family with progressive pseudorheumatoid dysplasia mimicking polyarticular juvenile idiopathic arthritis. 61
32894151 2020
11
Treat-to-target study for improved outcome in polyarticular juvenile idiopathic arthritis. 61
32299797 2020
12
Long-term outcomes in patients with polyarticular juvenile idiopathic arthritis receiving adalimumab with or without methotrexate. 61
32665432 2020
13
PADI4 (rs2240340), PDCD1 (rs10204525), and CTLA4 (231775) gene polymorphisms and polyarticular juvenile idiopathic arthritis. 61
32163016 2020
14
Functional Ability and Health-Related Quality of Life in Randomized Controlled Trials of Tocilizumab in Patients With Juvenile Idiopathic Arthritis. 61
32702212 2020
15
Type 1 interferonopathy presenting as juvenile idiopathic arthritis with interstitial lung disease: report of a new phenotype. 61
32398023 2020
16
Efficacy and safety of tocilizumab in a real-life observational cohort of patients with polyarticular juvenile idiopathic arthritis. 61
31359057 2020
17
Outcome Monitoring and Clinical Decision Support in Polyarticular Juvenile Idiopathic Arthritis. 61
31308202 2020
18
Infliximab therapy and outcomes in patients with polyarticular juvenile idiopathic arthritis: a single-center study in China. 61
31612428 2020
19
Biologic Therapies in Polyarticular Juvenile Idiopathic Arthritis. Comparison of Long-Term Safety Data from the German BIKER Registry. 61
31943968 2020
20
Height and sexual maturation in girls with juvenile idiopathic arthritis. 61
30339783 2020
21
Peripheral Blood Lymphocyte Analysis in Oligo- and Polyarticular Juvenile Idiopathic Arthritis Patients Receiving Methotrexate or Adalimumab Therapy: A Cross-Sectional Study. 61
33363071 2020
22
Physical Fitness in Patients With Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis Diagnosed in the Era of Biologics: A Controlled Cross-Sectional Study. 61
30474929 2019
23
Health-related quality of life during early aggressive treatment in patients with polyarticular juvenile idiopathic arthritis: results from randomized controlled trial. 61
31842940 2019
24
Arthritis in children with LRBA deficiency - case report and literature review. 61
31847838 2019
25
Canakinumab in Children with Familial Mediterranean Fever: A Single-Center, Retrospective Analysis. 61
31463794 2019
26
[Biologics in the treatment of juvenile idiopathic arthritis : A comparison of mono- and combination therapy with synthetic DMARDs]. 61
31087133 2019
27
Expanding the spectrum of A20 haploinsufficiency in two Chinese families: cases report. 61
31299923 2019
28
Comparison of Adults With Polyarticular Juvenile Idiopathic Arthritis to Adults With Rheumatoid Arthritis: A Cross-sectional Analysis of Clinical Features and Medication Use. 61
29781829 2019
29
Population Pharmacokinetics and Exposure-Response Modeling Analyses of Golimumab in Children With Moderately to Severely Active Ulcerative Colitis. 61
30536638 2019
30
Biallelic loss-of-function LACC1/FAMIN Mutations Presenting as Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis. 61
30872671 2019
31
Slow speed resistance exercise training in children with polyarticular juvenile idiopathic arthritis. 61
31191051 2019
32
PAIN PERCEPTION AND PAIN COPING MECHANISMS IN CHILDREN AND ADOLESCENTS WITH JUVENILE FIBROMYALGIA AND POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS. 61
29898009 2019
33
Pediatric mesenteric panniculitis: three cases and a review of the literature. 61
32105017 2019
34
Safety of Adalimumab in Pediatric Patients with Polyarticular Juvenile Idiopathic Arthritis, Enthesitis-Related Arthritis, Psoriasis, and Crohn's Disease. 61
30054164 2018
35
Physical activity in patients with oligo- and polyarticular juvenile idiopathic arthritis diagnosed in the era of biologics: a controlled cross-sectional study. 61
30333025 2018
36
SB5: An Adalimumab Biosimilar. 61
30251234 2018
37
Early prediction for over two years efficacy of the first biologic agent for polyarticular juvenile idiopathic arthritis: A multi-institutional study in Japan. 61
29293033 2018
38
Identification of enhanced IFN-γ signaling in polyarticular juvenile idiopathic arthritis with mass cytometry. 61
30089725 2018
39
Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis. 61
29426059 2018
40
Bilateral absence of the cruciate ligaments with meniscal dysplasia: Unexpected diagnosis in a child with juvenile idiopathic arthritis. 61
29635139 2018
41
Plasma exchange successfully treated macrophage activation syndrome in rheumatoid factor-positive polyarticular juvenile idiopathic arthritis with co-existing pneumonia. 61
28328098 2018
42
High Levels of DEK Autoantibodies in Sera of Patients With Polyarticular Juvenile Idiopathic Arthritis and With Early Disease Flares Following Cessation of Anti-Tumor Necrosis Factor Therapy. 61
29287303 2018
43
Switched Memory B Cells Are Increased in Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis and Their Change Over Time Is Related to Response to Tumor Necrosis Factor Inhibitors. 61
29316374 2018
44
Adiposity in Juvenile Psoriatic Arthritis. 61
29247150 2018
45
Is palindromic rheumatism amongst children a benign disease? 61
29439723 2018
46
Prior to extension, Transcriptomes of fibroblast-like Synoviocytes from extended and Polyarticular juvenile idiopathic arthritis are indistinguishable. 61
29310668 2018
47
The First Report of Multicentric Carpotarsal Osteolysis Syndrome Caused by MAFB Mutation in Asian. 61
30305815 2018
48
Protocols on classification, monitoring and therapy in children's rheumatology (PRO-KIND): results of the working group Polyarticular juvenile idiopathic arthritis. 61
29116003 2017
49
Tocilizumab (Actemra). 61
28841363 2017
50
Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. 61
28770976 2017
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Variations for Polyarticular Juvenile Idiopathic Arthritis

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Expression for Polyarticular Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Polyarticular Juvenile Idiopathic Arthritis.
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Pathways for Polyarticular Juvenile Idiopathic Arthritis

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Pathways related to Polyarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
IL-2 Pathway 63
Show member pathways
 12.87 TNF IFNG HLA-DRB4 BTK
2
Measles 36
Show member pathways
 12.27 TNF IFNG HLA-DRB4 BTK
3
Th17 cell differentiation 36
Show member pathways
 12.26 TNF IFNG HLA-DRB4
4
NF-kappaB Signaling 4
12.2 TNF IFNG BTK
5
Toxoplasmosis 36
Show member pathways
 11.82 TNF IFNG HLA-DRB4
6
Immune response NFAT in immune response 23
Show member pathways
 11.81 TNF IFNG HLA-DRB4 BTK
7
Tuberculosis 36
11.75 TNF IFNG HLA-DRB4
8
Osteoclast differentiation 36
11.44 TNF IFNG BTK
9
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.38 TNF IFNG
10
TGF-beta Receptor Signaling (WikiPathways) 1
11.35 TNF IFNG
11
Photodynamic therapy-induced AP-1 survival signaling. 1
11.28 TNF IFNG
12
Cellular Transformation by HTLV1 63
Show member pathways
 11.27 TNF IFNG
13
Malaria 36
11.26 TNF IFNG
14
MSP-RON Signaling 63
11.22 TNF IFNG
15
Aryl Hydrocarbon Receptor Pathway 1
11.21 TNF IFNG
16
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.15 TNF IFNG
17
African trypanosomiasis 36
11.05 TNF IFNG
18
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.01 TNF IFNG
19
Development and heterogeneity of the ILC family 1
10.94 TNF IFNG
20
Cytokines and Inflammatory Response 1
10.87 TNF IFNG
21
Rheumatoid arthritis 36
10.77 TNF IFNG HLA-DRB4
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GO Terms for Polyarticular Juvenile Idiopathic Arthritis

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Biological processes related to Polyarticular Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein localization to plasma membrane GO:1903078 9.58 TNF IFNG
2 humoral immune response GO:0006959 9.57 TNF IFNG
3 positive regulation of interleukin-1 beta production GO:0032731 9.56 TNF IFNG
4 positive regulation of protein complex assembly GO:0031334 9.55 TNF IFNG
5 positive regulation of cytokine production GO:0001819 9.54 TNF IFNG
6 positive regulation of phagocytosis GO:0050766 9.52 TNF IFNG
7 extrinsic apoptotic signaling pathway GO:0097191 9.51 TNF IFNG
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.49 TNF IFNG
9 positive regulation of chemokine production GO:0032722 9.48 TNF IFNG
10 microglial cell activation GO:0001774 9.46 TNF IFNG
11 positive regulation of osteoclast differentiation GO:0045672 9.43 TNF IFNG
12 positive regulation of amyloid-beta formation GO:1902004 9.4 TNF IFNG
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.37 TNF IFNG
14 astrocyte activation GO:0048143 9.32 TNF IFNG
15 negative regulation of amyloid-beta clearance GO:1900222 9.26 TNF IFNG
16 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 TNF IFNG
17 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 TNF IFNG
18 positive regulation of nitrogen compound metabolic process GO:0051173 8.62 TNF IFNG
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Sources for Polyarticular Juvenile Idiopathic Arthritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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