MCID: PLY065
MIFTS: 35

Polyarticular Onset Juvenile Idiopathic Arthritis

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Polyarticular Onset Juvenile Idiopathic Arthritis:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 53
Polyarticular Juvenile Rheumatoid Arthritis 53 73
Juvenile Polyarthritis Rheumatoid Factor Negative 53
Juvenile Polyarthritis Rheumatoid Factor Positive 53
Juvenile Chronic Polyarthritis 73

Classifications:



External Ids:

UMLS 73 C0311221

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards based summary : Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to rheumatoid arthritis and arthritis. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is TNFRSF11A (TNF Receptor Superfamily Member 11a), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Development Angiotensin activation of ERK. The drugs Abatacept and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, endothelial and bone, and related phenotypes are craniofacial and limbs/digits/tail

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.3 TNFRSF11A TNFRSF11B TNFSF11
2 arthritis 28.9 TNFRSF11A TNFSF11
3 juvenile rheumatoid arthritis 11.8
4 breast leiomyosarcoma 10.0 TNFRSF11A TNFSF11
5 aneurysmal bone cysts 10.0 TNFRSF11A TNFSF11
6 bone cancer 9.8 TNFRSF11A TNFSF11
7 multicentric reticulohistiocytosis 9.8 TNFRSF11B TNFSF11
8 kummell's disease 9.7 TNFRSF11B TNFSF11
9 periodontitis, chronic 9.7 TNFRSF11B TNFSF11
10 chronic apical periodontitis 9.7 TNFRSF11B TNFSF11
11 glucocorticoid-induced osteoporosis 9.7 TNFRSF11B TNFSF11
12 endosteal hyperostosis, autosomal dominant 9.7 TNFRSF11B TNFSF11
13 osteopetrosis 9.7 TNFRSF11A TNFSF11
14 osteonecrosis 9.6 TNFRSF11B TNFSF11
15 bone inflammation disease 9.6 TNFRSF11B TNFSF11
16 aortic valve disease 2 9.6 TNFRSF11B TNFSF11
17 synovitis 9.6 TNFRSF11B TNFSF11
18 arthropathy 9.5 TNFRSF11B TNFSF11
19 periodontitis 9.5 TNFRSF11B TNFSF11
20 psoriatic arthritis 9.3 TNFRSF11B TNFSF11
21 myeloma, multiple 9.2 TNFRSF11B TNFSF11
22 hemophilic arthropathy 9.1 TNFRSF11A TNFRSF11B TNFSF11
23 paget disease of bone 5, juvenile-onset 9.1 TNFRSF11A TNFRSF11B TNFSF11
24 familial expansile osteolysis 9.1 TNFRSF11A TNFRSF11B TNFSF11
25 multicentric carpotarsal osteolysis syndrome 9.1 TNFRSF11A TNFRSF11B TNFSF11
26 periapical periodontitis 9.1 TNFRSF11A TNFRSF11B TNFSF11
27 tooth resorption 9.1 TNFRSF11A TNFRSF11B TNFSF11
28 ischemic bone disease 9.1 TNFRSF11A TNFRSF11B TNFSF11
29 root resorption 9.1 TNFRSF11A TNFRSF11B TNFSF11
30 bone resorption disease 9.1 TNFRSF11A TNFRSF11B TNFSF11
31 bone remodeling disease 9.1 TNFRSF11A TNFRSF11B TNFSF11
32 giant cell tumor 9.0 TNFRSF11A TNFRSF11B TNFSF11
33 paget's disease of bone 9.0 TNFRSF11A TNFRSF11B TNFSF11
34 periodontal disease 9.0 TNFRSF11A TNFRSF11B TNFSF11
35 bone disease 9.0 TNFRSF11A TNFRSF11B TNFSF11
36 osteoporosis 9.0 TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Polyarticular Onset Juvenile Idiopathic Arthritis

MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.13 TNFRSF11A TNFRSF11B TNFSF11
2 limbs/digits/tail MP:0005371 8.8 TNFRSF11A TNFRSF11B TNFSF11

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

Drugs for Polyarticular Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 3 332348-12-6 10237
2
Infliximab Approved Phase 3 170277-31-3
3
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
4
Adalimumab Approved Phase 3 331731-18-1 16219006
5
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7 Folic Acid Antagonists Phase 3
8 Gastrointestinal Agents Phase 3
9 Dermatologic Agents Phase 3
10 Nucleic Acid Synthesis Inhibitors Phase 3
11 Vitamin B Complex Phase 3
12 Pharmaceutical Solutions Phase 3
13 Antibodies Phase 3
14 Immunoglobulins Phase 3
15 Antibodies, Monoclonal Phase 3
16 Immunosuppressive Agents Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Antirheumatic Agents Phase 3
19 Antimetabolites Phase 3
20 Antimetabolites, Antineoplastic Phase 3
21 Folate Nutraceutical Phase 3
22 Vitamin B9 Nutraceutical Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid Arthritis Completed NCT00690573 Phase 3
2 BMS-188667 in Children and Adolescents With Juvenile Rheumatoid Arthritis Completed NCT00095173 Phase 3 Abatacept;Placebo;Abatacept
3 A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid Arthritis Completed NCT00036374 Phase 3 Infliximab
4 Ultrasonography in Juvenile Idiopathic Arthritis Completed NCT01304420
5 Start Time Optimization of Biologics in Polyarticular JIA Recruiting NCT02593006

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

41
Neutrophil, Endothelial, Bone

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

(show all 16)
# Title Authors Year
1
Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study. ( 18334024 )
2008
2
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? ( 18802807 )
2008
3
Systemic lupus erythematosus in a patient treated with etanercept for polyarticular juvenile rheumatoid arthritis. ( 18061971 )
2007
4
A case-control sleep study in children with polyarticular juvenile rheumatoid arthritis. ( 16511937 )
2006
5
Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. ( 17002793 )
2006
6
Radiographic progression in children with polyarticular juvenile rheumatoid arthritis: a pilot study. ( 15708901 )
2005
7
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. ( 14979934 )
2004
8
Immune complexes contain immunoglobulin A rheumatoid factor in serum and synovial fluid of patients with polyarticular juvenile rheumatoid arthritis. ( 11961181 )
2002
9
Frequency of abnormal hand and wrist radiographs at time of diagnosis of polyarticular juvenile rheumatoid arthritis. ( 12375336 )
2002
10
Etanercept improves active polyarticular juvenile rheumatoid arthritis. ( 11326472 )
2001
11
Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. ( 10717011 )
2000
12
Increased circulating vascular endothelial growth factor is correlated with disease activity in polyarticular juvenile rheumatoid arthritis. ( 10529148 )
1999
13
The effect of methotrexate on the temporomandibular joint in polyarticular juvenile rheumatoid arthritis patients. ( 19078423 )
1999
14
Lymphocytic interstitial pneumonitis preceding polyarticular juvenile rheumatoid arthritis. ( 9779314 )
1998
15
Functional alpha 1-adrenergic receptors on leukocytes of patients with polyarticular juvenile rheumatoid arthritis. ( 8982123 )
1996
16
Aortic valve insufficiency and coronary artery narrowing in a child with polyarticular juvenile rheumatoid arthritis. ( 3280793 )
1988

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

Expression for Polyarticular Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for Polyarticular Onset Juvenile Idiopathic Arthritis

Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 TNFRSF11A TNFRSF11B TNFSF11
2
Show member pathways
12.39 TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.17 TNFRSF11A TNFRSF11B TNFSF11
4
Show member pathways
12.06 TNFRSF11A TNFSF11
5
Show member pathways
12 TNFRSF11A TNFSF11
6
Show member pathways
11.9 TNFRSF11A TNFRSF11B TNFSF11
7 11.8 TNFRSF11A TNFSF11
8 11.47 TNFRSF11A TNFSF11
9 11.44 TNFRSF11A TNFRSF11B TNFSF11
10 11.43 TNFRSF11A TNFSF11
11
Show member pathways
11.3 TNFRSF11A TNFSF11
12 10.85 TNFRSF11B TNFSF11
13 10.79 TNFRSF11A TNFRSF11B TNFSF11
14 10.4 TNFRSF11B TNFSF11
15 10 TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Polyarticular Onset Juvenile Idiopathic Arthritis

Cellular components related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.8 TNFRSF11A TNFRSF11B TNFSF11

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.71 TNFRSF11A TNFRSF11B TNFSF11
2 immune response GO:0006955 9.61 TNFRSF11A TNFRSF11B TNFSF11
3 regulation of cell proliferation GO:0042127 9.56 TNFRSF11A TNFRSF11B
4 response to lipopolysaccharide GO:0032496 9.55 TNFRSF11A TNFRSF11B
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.52 TNFRSF11A TNFSF11
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.51 TNFRSF11A TNFSF11
7 ossification GO:0001503 9.49 TNFRSF11A TNFSF11
8 apoptotic signaling pathway GO:0097190 9.48 TNFRSF11A TNFRSF11B
9 monocyte chemotaxis GO:0002548 9.46 TNFRSF11A TNFSF11
10 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 TNFRSF11A TNFRSF11B TNFSF11
11 osteoclast differentiation GO:0030316 9.4 TNFRSF11A TNFSF11
12 positive regulation of bone resorption GO:0045780 9.37 TNFRSF11A TNFSF11
13 mammary gland alveolus development GO:0060749 9.32 TNFRSF11A TNFSF11
14 TNFSF11-mediated signaling pathway GO:0071847 9.16 TNFRSF11A TNFSF11
15 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFRSF11A TNFSF11
16 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.62 TNFRSF11A TNFSF11

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.16 TNFRSF11B TNFSF11
2 signaling receptor activity GO:0038023 8.96 TNFRSF11A TNFRSF11B
3 tumor necrosis factor-activated receptor activity GO:0005031 8.62 TNFRSF11A TNFRSF11B

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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