MCID: PLY065
MIFTS: 37

Polyarticular Onset Juvenile Idiopathic Arthritis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Polyarticular Onset Juvenile Idiopathic Arthritis:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 54
Polyarticular Juvenile Rheumatoid Arthritis 54 74
Juvenile Polyarthritis Rheumatoid Factor Negative 54
Juvenile Polyarthritis Rheumatoid Factor Positive 54
Juvenile Chronic Polyarthritis 74

Classifications:



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Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards based summary : Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to rheumatoid arthritis and arthritis. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is TNFRSF11A (TNF Receptor Superfamily Member 11a), and among its related pathways/superpathways are Cytokine Signaling in Immune system and TNFR1 Pathway. The drugs Adalimumab and Abatacept have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and neutrophil, and related phenotypes are craniofacial and limbs/digits/tail

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 30.5 TNFRSF11A TNFRSF11B TNFSF11
2 arthritis 30.3 TNFRSF11A TNFSF11
3 juvenile rheumatoid arthritis 12.0
4 systemic lupus erythematosus 10.1
5 mannose-binding lectin deficiency 10.1
6 aortic valve insufficiency 10.1
7 lupus erythematosus 10.1
8 osteopetrosis 10.0 TNFRSF11A TNFSF11
9 osteopetrosis, autosomal recessive 7 10.0 TNFRSF11A TNFSF11
10 breast leiomyosarcoma 10.0 TNFRSF11A TNFSF11
11 osteopetrosis, autosomal recessive 2 9.9 TNFRSF11A TNFSF11
12 aneurysmal bone cysts 9.9 TNFRSF11A TNFSF11
13 arthropathy 9.9 TNFRSF11B TNFSF11
14 periodontitis 9.9 TNFRSF11B TNFSF11
15 multicentric reticulohistiocytosis 9.9 TNFRSF11B TNFSF11
16 kummell's disease 9.9 TNFRSF11B TNFSF11
17 periodontitis, chronic 9.8 TNFRSF11B TNFSF11
18 chronic apical periodontitis 9.8 TNFRSF11B TNFSF11
19 bone cancer 9.8 TNFRSF11A TNFSF11
20 glucocorticoid-induced osteoporosis 9.8 TNFRSF11B TNFSF11
21 endosteal hyperostosis, autosomal dominant 9.8 TNFRSF11B TNFSF11
22 osteonecrosis 9.8 TNFRSF11B TNFSF11
23 bone inflammation disease 9.8 TNFRSF11B TNFSF11
24 aortic valve disease 2 9.7 TNFRSF11B TNFSF11
25 synovitis 9.7 TNFRSF11B TNFSF11
26 psoriatic arthritis 9.6 TNFRSF11B TNFSF11
27 hemophilic arthropathy 9.6 TNFRSF11A TNFRSF11B TNFSF11
28 paget disease of bone 5, juvenile-onset 9.5 TNFRSF11A TNFRSF11B TNFSF11
29 familial expansile osteolysis 9.5 TNFRSF11A TNFRSF11B TNFSF11
30 multicentric carpotarsal osteolysis syndrome 9.5 TNFRSF11A TNFRSF11B TNFSF11
31 periapical periodontitis 9.5 TNFRSF11A TNFRSF11B TNFSF11
32 tooth resorption 9.5 TNFRSF11A TNFRSF11B TNFSF11
33 ischemic bone disease 9.5 TNFRSF11A TNFRSF11B TNFSF11
34 bone disease 9.5 TNFRSF11A TNFRSF11B TNFSF11
35 root resorption 9.5 TNFRSF11A TNFRSF11B TNFSF11
36 bone resorption disease 9.5 TNFRSF11A TNFRSF11B TNFSF11
37 bone remodeling disease 9.5 TNFRSF11A TNFRSF11B TNFSF11
38 paget's disease of bone 9.5 TNFRSF11A TNFRSF11B TNFSF11
39 giant cell tumor 9.5 TNFRSF11A TNFRSF11B TNFSF11
40 periodontal disease 9.5 TNFRSF11A TNFRSF11B TNFSF11
41 myeloma, multiple 9.5 TNFRSF11B TNFSF11
42 osteoporosis 9.5 TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Polyarticular Onset Juvenile Idiopathic Arthritis

MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.13 TNFRSF11A TNFRSF11B TNFSF11
2 limbs/digits/tail MP:0005371 8.8 TNFRSF11A TNFRSF11B TNFSF11

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

Drugs for Polyarticular Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 3 331731-18-1 16219006
2
Abatacept Approved Phase 3 332348-12-6 10237
3
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
4
leucovorin Approved Phase 3 58-05-9 6006 143
5
Infliximab Approved Phase 3 170277-31-3
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7 Immunoglobulins Phase 3
8 Anti-Inflammatory Agents Phase 3
9 Antibodies, Monoclonal Phase 3
10 Antibodies Phase 3
11 Antirheumatic Agents Phase 3
12 Pharmaceutical Solutions Phase 3
13 Immunologic Factors Phase 3
14 Immunosuppressive Agents Phase 3
15 Antimetabolites Phase 3
16 Vitamin B Complex Phase 3
17 Folate Phase 3
18 Vitamin B9 Phase 3
19 Nucleic Acid Synthesis Inhibitors Phase 3
20 Antimetabolites, Antineoplastic Phase 3
21 Folic Acid Antagonists Phase 3
22 Gastrointestinal Agents Phase 3
23 Dermatologic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid Arthritis Completed NCT00690573 Phase 3
2 BMS-188667 in Children and Adolescents With Juvenile Rheumatoid Arthritis Completed NCT00095173 Phase 3 Abatacept;Placebo;Abatacept
3 A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid Arthritis Completed NCT00036374 Phase 3 Infliximab
4 Ultrasonography in Juvenile Idiopathic Arthritis Completed NCT01304420
5 Start Time Optimization of Biologics in Polyarticular JIA Active, not recruiting NCT02593006

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

42
Bone, Endothelial, Neutrophil, Nk Cells

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

(show all 33)
# Title Authors Year
1
Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study. ( 18334024 )
2008
2
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? ( 18802807 )
2008
3
Systemic lupus erythematosus in a patient treated with etanercept for polyarticular juvenile rheumatoid arthritis. ( 18061971 )
2007
4
A case-control sleep study in children with polyarticular juvenile rheumatoid arthritis. ( 16511937 )
2006
5
Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. ( 17002793 )
2006
6
Radiographic progression in children with polyarticular juvenile rheumatoid arthritis: a pilot study. ( 15708901 )
2005
7
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. ( 14979934 )
2004
8
Immune complexes contain immunoglobulin A rheumatoid factor in serum and synovial fluid of patients with polyarticular juvenile rheumatoid arthritis. ( 11961181 )
2002
9
Frequency of abnormal hand and wrist radiographs at time of diagnosis of polyarticular juvenile rheumatoid arthritis. ( 12375336 )
2002
10
Etanercept improves active polyarticular juvenile rheumatoid arthritis. ( 11326472 )
2001
11
Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. ( 10717011 )
2000
12
Increased circulating vascular endothelial growth factor is correlated with disease activity in polyarticular juvenile rheumatoid arthritis. ( 10529148 )
1999
13
The effect of methotrexate on the temporomandibular joint in polyarticular juvenile rheumatoid arthritis patients. ( 19078423 )
1999
14
Lymphocytic interstitial pneumonitis preceding polyarticular juvenile rheumatoid arthritis. ( 9779314 )
1998
15
Functional alpha 1-adrenergic receptors on leukocytes of patients with polyarticular juvenile rheumatoid arthritis. ( 8982123 )
1996
16
Mitral and aortic insufficiency in polyarticular juvenile rheumatoid arthritis. ( 8696002 )
1996
17
Intravenous immunoglobulin in the treatment of polyarticular juvenile rheumatoid arthritis: a phase I/II study. Pediatric Rheumatology Collaborative Study Group. ( 8724309 )
1996
18
Serum levels of hyaluronic acid indicate the severity of joint symptoms in patients with systemic and polyarticular juvenile rheumatoid arthritis. ( 8923375 )
1996
19
Prevalence of antihuman parvovirus B19 IgG antibodies in patients with refractory rheumatoid arthritis and polyarticular juvenile rheumatoid arthritis. ( 7839075 )
1994
20
Complement activation and immune complexes in children with polyarticular juvenile rheumatoid arthritis: a longitudinal study. ( 7932426 )
1994
21
Mitral and aortic insufficiency in polyarticular juvenile rheumatoid arthritis. ( 8047499 )
1994
22
Rifamycin SV administered by intra-articular infiltrations shows disease modifying activity in patients with pauci- or polyarticular juvenile rheumatoid arthritis. ( 8112482 )
1993
23
DNA analysis of HLA-DR, DQ, and DP alleles in children with polyarticular juvenile rheumatoid arthritis. ( 1361203 )
1992
24
Physical fitness levels in children with polyarticular juvenile rheumatoid arthritis. ( 1390970 )
1992
25
Distal interphalangeal joint abnormalities in children with polyarticular juvenile rheumatoid arthritis. ( 1895269 )
1991
26
Aortic valve insufficiency and coronary artery narrowing in a child with polyarticular juvenile rheumatoid arthritis. ( 3280793 )
1988
27
Immunoregulatory aberrations in patients with polyarticular juvenile rheumatoid arthritis. ( 2832112 )
1988
28
Detection of the major rheumatoid factor cross-reactive idiotype precedes human IgG binding activity in a patient with polyarticular juvenile rheumatoid arthritis. ( 3230564 )
1988
29
Natural killer (NK) cells at inflammatory sites of patients with rheumatoid arthritis and IgM rheumatoid factor positive polyarticular juvenile rheumatoid arthritis. ( 3497759 )
1987
30
Gold sodium thiomalate and D-penicillamine. A controlled, comparative study in patients with pauciarticular and polyarticular juvenile rheumatoid arthritis. ( 3936167 )
1985
31
Evidence for intravascular coagulation in systemic onset, but not polyarticular, juvenile rheumatoid arthritis. ( 3977974 )
1985
32
Naproxen and acetylsalicylic acid in the treatment of pauciarticular and polyarticular juvenile rheumatoid arthritis. Assessment of tolerance and efficacy in a single-centre 24-week double-blind parallel study. ( 6395321 )
1984
33
Assays of complement in polyarticular juvenile rheumatoid arthritis. ( 263920 )
1977

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

Expression for Polyarticular Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for Polyarticular Onset Juvenile Idiopathic Arthritis

Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.82 TNFRSF11A TNFRSF11B TNFSF11
2
Show member pathways
12.45 TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.39 TNFRSF11A TNFRSF11B TNFSF11
4
Show member pathways
12.17 TNFRSF11A TNFRSF11B TNFSF11
5
Show member pathways
12.14 TNFRSF11A TNFRSF11B TNFSF11
6 12.09 TNFRSF11A TNFSF11
7
Show member pathways
12.02 TNFRSF11A TNFSF11
8
Show member pathways
11.9 TNFRSF11A TNFRSF11B TNFSF11
9
Show member pathways
11.81 TNFRSF11A TNFSF11
10 11.81 TNFRSF11A TNFSF11
11 11.5 TNFRSF11A TNFSF11
12 11.47 TNFRSF11A TNFSF11
13 11.44 TNFRSF11A TNFRSF11B TNFSF11
14
Show member pathways
11.34 TNFRSF11A TNFSF11
15 10.85 TNFRSF11B TNFSF11
16 10.79 TNFRSF11A TNFRSF11B TNFSF11
17 10.4 TNFRSF11B TNFSF11
18 10 TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Polyarticular Onset Juvenile Idiopathic Arthritis

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.49 TNFRSF11A TNFSF11
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.48 TNFRSF11A TNFSF11
3 ossification GO:0001503 9.46 TNFRSF11A TNFSF11
4 monocyte chemotaxis GO:0002548 9.43 TNFRSF11A TNFSF11
5 osteoclast differentiation GO:0030316 9.4 TNFRSF11A TNFSF11
6 positive regulation of bone resorption GO:0045780 9.37 TNFRSF11A TNFSF11
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.33 TNFRSF11A TNFRSF11B TNFSF11
8 mammary gland alveolus development GO:0060749 9.32 TNFRSF11A TNFSF11
9 TNFSF11-mediated signaling pathway GO:0071847 9.26 TNFRSF11A TNFSF11
10 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.96 TNFRSF11A TNFSF11
11 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.62 TNFRSF11A TNFSF11

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 8.96 TNFRSF11A TNFRSF11B
2 cytokine activity GO:0005125 8.62 TNFRSF11B TNFSF11

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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