MCID: PLY065
MIFTS: 33

Polyarticular Onset Juvenile Idiopathic Arthritis

Categories: Bone diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Polyarticular Onset Juvenile Idiopathic Arthritis:

Name: Polyarticular Onset Juvenile Idiopathic Arthritis 20
Polyarticular Juvenile Rheumatoid Arthritis 20 70
Juvenile Polyarthritis Rheumatoid Factor Negative 20
Juvenile Polyarthritis Rheumatoid Factor Positive 20
Juvenile Chronic Polyarthritis 70

Classifications:



External Ids:

UMLS 70 C0311221 C0409667

Summaries for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards based summary : Polyarticular Onset Juvenile Idiopathic Arthritis, also known as polyarticular juvenile rheumatoid arthritis, is related to synovitis and rheumatoid arthritis. An important gene associated with Polyarticular Onset Juvenile Idiopathic Arthritis is TNFRSF11A (TNF Receptor Superfamily Member 11a), and among its related pathways/superpathways are Cytokine Signaling in Immune system and TNFR1 Pathway. The drugs Methotrexate and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, nk cells and t cells, and related phenotypes are craniofacial and limbs/digits/tail

Related Diseases for Polyarticular Onset Juvenile Idiopathic Arthritis

Diseases in the Polyarticular Juvenile Idiopathic Arthritis family:

Polyarticular Onset Juvenile Idiopathic Arthritis

Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 synovitis 29.8 TNFSF11 TNFRSF11B
2 rheumatoid arthritis 29.6 TNFSF11 TNFRSF11B TNFRSF11A
3 arthropathy 29.5 TNFSF11 TNFRSF11B TNFRSF11A
4 aortic valve insufficiency 10.3
5 juvenile rheumatoid arthritis 10.2
6 arthritis 10.2
7 polyarticular juvenile idiopathic arthritis 10.2
8 autoimmune disease 10.1
9 systemic lupus erythematosus 10.1
10 mannose-binding lectin deficiency 10.1
11 juvenile arthritis 10.1
12 purpura fulminans 10.1
13 disseminated intravascular coagulation 10.1
14 hemopericardium 10.1
15 pericardial effusion 10.1
16 plica syndrome 10.1
17 thrombocytosis 10.1
18 purpura 10.1
19 aortitis 10.1
20 lupus erythematosus 10.1
21 aneurysmal bone cysts 9.9 TNFSF11 TNFRSF11A
22 giant cell reparative granuloma 9.9 TNFSF11 TNFRSF11A
23 tooth resorption 9.9 TNFSF11 TNFRSF11A
24 osteopetrosis, autosomal recessive 7 9.9 TNFSF11 TNFRSF11A
25 bone giant cell tumor 9.9 TNFSF11 TNFRSF11A
26 ischemic bone disease 9.9 TNFSF11 TNFRSF11A
27 fibrous dysplasia 9.9 TNFSF11 TNFRSF11A
28 periodontitis, chronic 9.8 TNFSF11 TNFRSF11B
29 multicentric reticulohistiocytosis 9.8 TNFSF11 TNFRSF11B
30 chronic apical periodontitis 9.8 TNFSF11 TNFRSF11B
31 glucocorticoid-induced osteoporosis 9.8 TNFSF11 TNFRSF11B
32 renal osteodystrophy 9.8 TNFSF11 TNFRSF11B
33 periostitis 9.8 TNFRSF11B TNFRSF11A
34 ankylosis 9.8 TNFSF11 TNFRSF11B
35 osteonecrosis 9.8 TNFSF11 TNFRSF11B
36 spondyloarthropathy 1 9.7 TNFSF11 TNFRSF11B
37 bone cancer 9.7 TNFSF11 TNFRSF11A
38 endosteal hyperostosis, autosomal dominant 9.7 TNFSF11 TNFRSF11B
39 hyperparathyroidism 9.7 TNFSF11 TNFRSF11B
40 osteoarthritis 9.6 TNFSF11 TNFRSF11B
41 hemophilic arthropathy 9.5 TNFSF11 TNFRSF11B TNFRSF11A
42 disseminated chorioretinitis 9.5 TNFSF11 TNFRSF11B TNFRSF11A
43 paget disease of bone 5, juvenile-onset 9.5 TNFSF11 TNFRSF11B TNFRSF11A
44 multicentric carpotarsal osteolysis syndrome 9.5 TNFSF11 TNFRSF11B TNFRSF11A
45 root resorption 9.5 TNFSF11 TNFRSF11B TNFRSF11A
46 familial expansile osteolysis 9.5 TNFSF11 TNFRSF11B TNFRSF11A
47 benign giant cell tumor 9.5 TNFSF11 TNFRSF11B TNFRSF11A
48 mammary paget's disease 9.5 TNFSF11 TNFRSF11B TNFRSF11A
49 craniometaphyseal dysplasia, autosomal dominant 9.5 TNFSF11 TNFRSF11B TNFRSF11A
50 paget's disease of bone 9.5 TNFSF11 TNFRSF11B TNFRSF11A

Graphical network of the top 20 diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis:



Diseases related to Polyarticular Onset Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Polyarticular Onset Juvenile Idiopathic Arthritis

MGI Mouse Phenotypes related to Polyarticular Onset Juvenile Idiopathic Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.13 TNFRSF11A TNFRSF11B TNFSF11
2 limbs/digits/tail MP:0005371 8.8 TNFRSF11A TNFRSF11B TNFSF11

Drugs & Therapeutics for Polyarticular Onset Juvenile Idiopathic Arthritis

Drugs for Polyarticular Onset Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
2
Etanercept Approved, Investigational Phase 4 185243-69-0
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
6
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
9
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
10
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
11
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
12 Antirheumatic Agents Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Gastrointestinal Agents Phase 4
15 Dermatologic Agents Phase 4
16 Immunosuppressive Agents Phase 4
17 Immunologic Factors Phase 4
18 Vitamin B9 Phase 4
19 Folic Acid Antagonists Phase 4
20 Hormones Phase 4
21 Methylprednisolone Acetate Phase 4
22 Antiemetics Phase 4
23 Folate Phase 4
24 Vitamin B Complex Phase 4
25 Neuroprotective Agents Phase 4
26 glucocorticoids Phase 4
27 Protective Agents Phase 4
28 Hormone Antagonists Phase 4
29 Antineoplastic Agents, Hormonal Phase 4
30 Antimetabolites Phase 4
31 Analgesics Phase 4
32 Anti-Inflammatory Agents, Non-Steroidal Phase 4
33 Analgesics, Non-Narcotic Phase 4
34
Adalimumab Approved, Experimental Phase 3 331731-18-1 16219006
35
Infliximab Approved Phase 3 170277-31-3
36
Abatacept Approved Phase 3 332348-12-6 10237
37 Immunoglobulins Phase 3
38 Antibodies Phase 3
39 Antibodies, Monoclonal Phase 3
40 Pharmaceutical Solutions Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Early Aggressive Therapy in Juvenile Idiopathic Arthritis (TREAT in JIA) Completed NCT00443430 Phase 4 methotrexate;methotrexate - etanercept - prednisolone arm
2 A Multicenter, Open-label Study of the Safety, Efficacy, and Pharmacokinetics of the Human Anti-TNF Monoclonal Antibody Adalimumab in Children With Polyarticular Juvenile Rheumatoid Arthritis Completed NCT00690573 Phase 3
3 A Randomized, Double-Blind Trial of Anti-TNF Chimeric Monoclonal Antibody (Infliximab) in Combination With Methotrexate for the Treatment of Patients With Polyarticular Juvenile Rheumatoid Arthritis Completed NCT00036374 Phase 3 Infliximab
4 A Phase III, Multi-Center, Multi-National, Randomized Withdrawal Study to Evaluate the Safety and Efficacy of BMS-188667 in Children and Adolescents With Active Polyarticular Juvenile Rheumatoid Arthritis (JRA) Completed NCT00095173 Phase 3 Abatacept;Placebo;Abatacept
5 Start Time Optimization of Biologics in Polyarticular JIA Completed NCT02593006

Search NIH Clinical Center for Polyarticular Onset Juvenile Idiopathic Arthritis

Genetic Tests for Polyarticular Onset Juvenile Idiopathic Arthritis

Anatomical Context for Polyarticular Onset Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Polyarticular Onset Juvenile Idiopathic Arthritis:

40
Bone, Nk Cells, T Cells, Endothelial

Publications for Polyarticular Onset Juvenile Idiopathic Arthritis

Articles related to Polyarticular Onset Juvenile Idiopathic Arthritis:

(show top 50) (show all 65)
# Title Authors PMID Year
1
Pustular eruption induced by etanercept in a patient with ankylosing spondylitis: a rare side effect. 61
28058373 2015
2
Surgical considerations about amyloid goiter. 61
22867857 2013
3
Juvenile idiopathic arthritis: review of the literature and case report. 61
23595241 2013
4
Cutaneous sarcoidosis occurring during anti-TNF-alpha treatment: report of two cases. 61
20185892 2010
5
Osteoprotegerin/RANKL system imbalance in active polyarticular-onset juvenile idiopathic arthritis: a bone damage biomarker? 61
18802807 2008
6
Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study. 61
18334024 2008
7
Systemic lupus erythematosus in a patient treated with etanercept for polyarticular juvenile rheumatoid arthritis. 61
18061971 2007
8
Long-term outcome of juvenile idiopathic arthritis following a placebo-controlled trial: sustained benefits of early sulfasalazine treatment. 61
17491099 2007
9
A case-control sleep study in children with polyarticular juvenile rheumatoid arthritis. 61
16511937 2006
10
Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. 61
17002793 2006
11
Leflunomide or methotrexate for juvenile rheumatoid arthritis. 61
15843668 2005
12
Radiographic progression in children with polyarticular juvenile rheumatoid arthritis: a pilot study. 61
15708901 2005
13
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. 61
14979934 2004
14
Frequency of abnormal hand and wrist radiographs at time of diagnosis of polyarticular juvenile rheumatoid arthritis. 61
12375336 2002
15
Immune complexes contain immunoglobulin A rheumatoid factor in serum and synovial fluid of patients with polyarticular juvenile rheumatoid arthritis. 61
11961181 2002
16
Etanercept improves active polyarticular juvenile rheumatoid arthritis. 61
11326472 2001
17
Effect of methotrexate on the temporomandibular joint and facial morphology in juvenile rheumatoid arthritis patients. 61
10893476 2000
18
Anti-keratin antibodies in patients with rheumatoid arthritis. 61
10969490 2000
19
Pulmonary hemosiderosis with juvenile rheumatoid arthritis: a case report. 61
10936982 2000
20
Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. 61
10717011 2000
21
The effect of methotrexate on the temporomandibular joint in polyarticular juvenile rheumatoid arthritis patients. 61
19078423 1999
22
Increased circulating vascular endothelial growth factor is correlated with disease activity in polyarticular juvenile rheumatoid arthritis. 61
10529148 1999
23
Effects of an eight-week physical conditioning program on disease signs and symptoms in children with chronic arthritis. 61
10513491 1999
24
HLA associations of seropositive rheumatoid arthritis in a Cree and Ojibway population. 61
9858424 1998
25
Lymphocytic interstitial pneumonitis preceding polyarticular juvenile rheumatoid arthritis. 61
9779314 1998
26
Pulmonary edema as a result of chronic upper airway obstruction. 61
9926177 1998
27
Cerebral vasculitis in an adolescent with juvenile rheumatoid arthritis. 61
9682891 1998
28
Comparative sequence analysis of the human T cell receptor beta chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies: evidence for antigenic selection of T cells in the synovium. 61
9506577 1998
29
Juvenile rheumatoid arthritis in African Americans. 61
9292811 1997
30
Juvenile rheumatoid arthritis-like polyarthritis in chromosome 22q11.2 deletion syndrome (DiGeorge anomalad/velocardiofacial syndrome/conotruncal anomaly face syndrome). 61
9082929 1997
31
Functional alpha 1-adrenergic receptors on leukocytes of patients with polyarticular juvenile rheumatoid arthritis. 61
8982123 1996
32
Serum levels of hyaluronic acid indicate the severity of joint symptoms in patients with systemic and polyarticular juvenile rheumatoid arthritis. 61
8923375 1996
33
Intravenous immunoglobulin in the treatment of polyarticular juvenile rheumatoid arthritis: a phase I/II study. Pediatric Rheumatology Collaborative Study Group. 61
8724309 1996
34
Mitral and aortic insufficiency in polyarticular juvenile rheumatoid arthritis. 61
8696002 1996
35
Anterior dissection of popliteal cyst causing anterior compartment syndrome. 61
7562776 1995
36
Evaluation of disease activity by laboratory tests in juvenile rheumatoid arthritis. 61
8705012 1995
37
Clinical and radiographic evaluation of juvenile rheumatoid arthritis: report of a case. 61
7754457 1994
38
Complement activation and immune complexes in children with polyarticular juvenile rheumatoid arthritis: a longitudinal study. 61
7932426 1994
39
Mitral and aortic insufficiency in polyarticular juvenile rheumatoid arthritis. 61
8047499 1994
40
Prevalence of antihuman parvovirus B19 IgG antibodies in patients with refractory rheumatoid arthritis and polyarticular juvenile rheumatoid arthritis. 61
7839075 1994
41
Rifamycin SV administered by intra-articular infiltrations shows disease modifying activity in patients with pauci- or polyarticular juvenile rheumatoid arthritis. 61
8112482 1993
42
DNA analysis of HLA-DR, DQ, and DP alleles in children with polyarticular juvenile rheumatoid arthritis. 61
1361203 1992
43
Physical fitness levels in children with polyarticular juvenile rheumatoid arthritis. 61
1390970 1992
44
Morbidity associated with long-term methotrexate therapy in juvenile rheumatoid arthritis. 61
1538301 1992
45
Carpo-metacarpal growth disturbance and the assessment of carpal narrowing in children with juvenile rheumatoid arthritis. 61
1917408 1991
46
Distal interphalangeal joint abnormalities in children with polyarticular juvenile rheumatoid arthritis. 61
1895269 1991
47
HLA extended haplotypes in childhood and adult onset HLA-DR4-associated arthropathies. 61
2343452 1990
48
Lymphedema associated with juvenile rheumatoid arthritis. 61
2681759 1989
49
Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: production and characterization. 61
2805416 1989
50
Involvement of nonarticular cartilage, as demonstrated by release of a cartilage-specific protein, in rheumatoid arthritis. 61
2775318 1989

Variations for Polyarticular Onset Juvenile Idiopathic Arthritis

Expression for Polyarticular Onset Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Polyarticular Onset Juvenile Idiopathic Arthritis.

Pathways for Polyarticular Onset Juvenile Idiopathic Arthritis

Pathways related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 TNFSF11 TNFRSF11B TNFRSF11A
2
Show member pathways
12.51 TNFSF11 TNFRSF11B TNFRSF11A
3
Show member pathways
12.12 TNFSF11 TNFRSF11B TNFRSF11A
4 12.05 TNFSF11 TNFRSF11A
5
Show member pathways
12.03 TNFSF11 TNFRSF11B TNFRSF11A
6
Show member pathways
11.98 TNFSF11 TNFRSF11A
7 11.78 TNFSF11 TNFRSF11A
8 11.49 TNFSF11 TNFRSF11A
9 11.4 TNFSF11 TNFRSF11A
10
Show member pathways
11.27 TNFSF11 TNFRSF11A
11
Show member pathways
11.25 TNFSF11 TNFRSF11B TNFRSF11A
12 10.79 TNFSF11 TNFRSF11B TNFRSF11A
13 10.4 TNFSF11 TNFRSF11B
14 10 TNFSF11 TNFRSF11B TNFRSF11A

GO Terms for Polyarticular Onset Juvenile Idiopathic Arthritis

Biological processes related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.49 TNFSF11 TNFRSF11A
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.48 TNFSF11 TNFRSF11A
3 ossification GO:0001503 9.46 TNFSF11 TNFRSF11A
4 monocyte chemotaxis GO:0002548 9.43 TNFSF11 TNFRSF11A
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 TNFSF11 TNFRSF11B TNFRSF11A
6 osteoclast differentiation GO:0030316 9.4 TNFSF11 TNFRSF11A
7 positive regulation of bone resorption GO:0045780 9.37 TNFSF11 TNFRSF11A
8 mammary gland alveolus development GO:0060749 9.32 TNFSF11 TNFRSF11A
9 TNFSF11-mediated signaling pathway GO:0071847 9.16 TNFSF11 TNFRSF11A
10 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.96 TNFSF11 TNFRSF11A
11 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.62 TNFSF11 TNFRSF11A

Molecular functions related to Polyarticular Onset Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.96 TNFSF11 TNFRSF11B
2 signaling receptor activity GO:0038023 8.62 TNFRSF11B TNFRSF11A

Sources for Polyarticular Onset Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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