MCID: PLY010
MIFTS: 31

Polyclonal Hypergammaglobulinemia

Categories: Immune diseases, Metabolic diseases

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

Summaries for Polyclonal Hypergammaglobulinemia

MalaCards based summary : Polyclonal Hypergammaglobulinemia is related to histiocytosis and histiocytosis-lymphadenopathy plus syndrome. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (Interleukin 6), and among its related pathways/superpathways are T cell receptor signaling pathway and Immune response IFN gamma signaling pathway. The drugs Autoantibodies and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and bone marrow.

Related Diseases for Polyclonal Hypergammaglobulinemia

Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 histiocytosis 30.1 SERPINA3 SLC29A3
2 histiocytosis-lymphadenopathy plus syndrome 11.6
3 gaucher disease, type iii 11.4
4 lymphoma 10.4
5 leukemia 10.2
6 middle ear disease 10.2 IL6 SLC29A3
7 hairy cell leukemia 10.2
8 rheumatoid arthritis, systemic juvenile 10.1 IL6 SERPINA3
9 streptococcal toxic-shock syndrome 10.1 IL6 MYOM2
10 extramedullary plasmacytoma 10.1 IL6 MYOM2
11 impetigo 10.1 IL6 MYOM2
12 osteosclerotic myeloma 10.1 IL6 MYOM2
13 poems syndrome 10.1 IL6 MYOM2
14 necrotizing fasciitis 10.1 IL6 MYOM2
15 monoclonal gammopathy of uncertain significance 10.1 IL6 MYOM2
16 plasma protein metabolism disease 10.1 MYOM2 SERPINA3
17 commensal bacterial infectious disease 10.1 IL6 MYOM2
18 temporal arteritis 10.1 IL6 SERPINA3
19 rheumatic fever 10.1 IL6 MYOM2
20 mature b-cell neoplasm 10.0 IL6 MYOM2
21 rheumatic heart disease 10.0 IL6 MYOM2
22 metal allergy 10.0 CD4 CD8A
23 hepatocellular carcinoma 10.0
24 rheumatoid arthritis 10.0
25 leukemia, acute myeloid 10.0
26 arthritis 10.0
27 autoimmune hepatitis 10.0
28 hepatitis 10.0
29 mantle cell lymphoma 10.0
30 nodal marginal zone lymphoma 10.0
31 blue toe syndrome 10.0
32 myeloid leukemia 10.0
33 leishmaniasis 10.0
34 visceral leishmaniasis 10.0
35 bone marrow necrosis 10.0
36 thymus lipoma 10.0 CD4 CD8A
37 immune system organ benign neoplasm 10.0 CD4 CD8A
38 ecthyma 10.0 CD4 MYOM2
39 upper respiratory tract disease 10.0 IL6 MYOM2
40 melkersson-rosenthal syndrome 9.9 CD4 CD8A
41 human immunodeficiency virus infectious disease 9.9 CD4 IL6
42 cutaneous solitary mastocytoma 9.9 CD2 SERPINA3
43 toxic shock syndrome 9.9 IL6 MYOM2
44 specific bursitis often of occupational origin 9.9 CD2 CD8A
45 olecranon bursitis 9.9 CD2 CD8A
46 reticulum cell sarcoma 9.8 CD2 CD4
47 acquired immunodeficiency syndrome 9.8 CD4 IL6
48 xanthogranulomatous cholecystitis 9.8 CD4 CD8A SERPINA3
49 peripheral nervous system disease 9.7 IL6 MYOM2
50 leukocyte disease 9.7 CD2 IL6 MYOM2

Comorbidity relations with Polyclonal Hypergammaglobulinemia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to Polyclonal Hypergammaglobulinemia

Symptoms & Phenotypes for Polyclonal Hypergammaglobulinemia

Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

Drugs for Polyclonal Hypergammaglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Autoantibodies
2 Antibodies
3 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Auto-antibodies Prevalence and CD1 Role in Gaucher Disease Completed NCT02650219

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

Anatomical Context for Polyclonal Hypergammaglobulinemia

MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

42
Bone, B Cells, Bone Marrow, Myeloid, T Cells, Colon, Smooth Muscle

Publications for Polyclonal Hypergammaglobulinemia

Articles related to Polyclonal Hypergammaglobulinemia:

(show all 24)
# Title Authors Year
1
A Case of Lethal Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Medical Challenge for the Forensic Pathologist. ( 27364300 )
2016
2
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. ( 21316456 )
2011
3
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. ( 19008139 )
2009
4
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. ( 19586961 )
2009
5
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. ( 18336788 )
2008
6
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. ( 15802958 )
2005
7
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. ( 14765269 )
2004
8
Decreased anion gap in polyclonal hypergammaglobulinemia. ( 11937082 )
2002
9
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. ( 11399611 )
2000
10
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. ( 10550554 )
1999
11
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. ( 9786355 )
1998
12
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. ( 9185918 )
1997
13
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. ( 8589372 )
1995
14
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. ( 7812213 )
1994
15
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. ( 8432045 )
1993
16
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. ( 1633368 )
1992
17
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. ( 1650855 )
1991
18
[Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. ( 2386010 )
1990
19
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. ( 3318265 )
1987
20
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. ( 3777978 )
1986
21
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. ( 6230148 )
1984
22
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. ( 6464210 )
1984
23
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. ( 78444 )
1978
24
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. ( 4123735 )
1973

Variations for Polyclonal Hypergammaglobulinemia

Expression for Polyclonal Hypergammaglobulinemia

Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for Polyclonal Hypergammaglobulinemia

GO Terms for Polyclonal Hypergammaglobulinemia

Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD2 CD4 CD8A
2 T cell receptor complex GO:0042101 8.62 CD4 CD8A

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.58 CD4 CD8A IL6
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.43 CD4 CD8A
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.37 CD4 IL6
4 defense response to Gram-negative bacterium GO:0050829 9.32 CD4 IL6
5 positive regulation of T cell proliferation GO:0042102 9.26 CD4 IL6
6 acute-phase response GO:0006953 9.16 IL6 SERPINA3
7 cell surface receptor signaling pathway GO:0007166 9.13 CD2 CD4 CD8A
8 T cell activation GO:0042110 8.8 CD2 CD4 CD8A

Molecular functions related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.62 CD4 CD8A

Sources for Polyclonal Hypergammaglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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