MCID: PLY010
MIFTS: 33

Polyclonal Hypergammaglobulinemia

Categories: Immune diseases, Metabolic diseases

Aliases & Classifications for Polyclonal Hypergammaglobulinemia

Summaries for Polyclonal Hypergammaglobulinemia

MalaCards based summary : Polyclonal Hypergammaglobulinemia is related to histiocytosis-lymphadenopathy plus syndrome and gaucher disease, type iii. An important gene associated with Polyclonal Hypergammaglobulinemia is IL6 (Interleukin 6), and among its related pathways/superpathways are T cell receptor signaling pathway and Immune response IFN gamma signaling pathway. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and b cells.

Related Diseases for Polyclonal Hypergammaglobulinemia

Diseases related to Polyclonal Hypergammaglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 histiocytosis-lymphadenopathy plus syndrome 11.5
2 gaucher disease, type iii 11.4
3 lymphoma 10.4
4 hairy cell leukemia 10.1
5 middle ear disease 10.1 SLC29A3 IL6
6 streptococcal toxic-shock syndrome 10.1 MYOM2 IL6
7 extramedullary plasmacytoma 10.1 MYOM2 IL6
8 impetigo 10.1 MYOM2 IL6
9 osteosclerotic myeloma 10.1 MYOM2 IL6
10 poems syndrome 10.1 MYOM2 IL6
11 pyelitis 10.1 LYZ IL6
12 necrotizing fasciitis 10.1 MYOM2 IL6
13 plasma cell neoplasm 10.1 MYOM2 IL6
14 monoclonal gammopathy of uncertain significance 10.1 MYOM2 IL6
15 commensal bacterial infectious disease 10.0 MYOM2 IL6
16 ecthyma 10.0 MYOM2 CD4
17 human immunodeficiency virus infectious disease 10.0 IL6 CD4
18 rheumatic fever 10.0 MYOM2 IL6
19 mature b-cell neoplasm 10.0 MYOM2 IL6
20 reticulum cell sarcoma 10.0 CD4 CD2
21 rheumatic heart disease 10.0 MYOM2 IL6
22 lobomycosis 10.0 LYZ CD2
23 cutaneous solitary mastocytoma 10.0 LYZ CD2
24 upper respiratory tract disease 10.0 MYOM2 IL6
25 hypersensitivity reaction type iv disease 10.0 MYOM2 LYZ
26 acquired immunodeficiency syndrome 10.0 IL6 CD4
27 toxic shock syndrome 10.0 MYOM2 IL6
28 hepatocellular carcinoma 10.0
29 rheumatoid arthritis 10.0
30 leukemia, acute myeloid 10.0
31 arthritis 10.0
32 autoimmune hepatitis 10.0
33 b-cell lymphomas 10.0
34 hepatitis 10.0
35 leukemia 10.0
36 mantle cell lymphoma 10.0
37 blue toe syndrome 10.0
38 histiocytosis 10.0
39 lymphosarcoma 10.0
40 myeloid leukemia 10.0
41 leishmaniasis 10.0
42 visceral leishmaniasis 10.0
43 bone marrow necrosis 10.0
44 lymphatic system cancer 10.0 LYZ CD2
45 metal allergy 10.0 CD8A CD4
46 meningitis 9.9 LYZ IL6
47 thymus lipoma 9.9 CD8A CD4
48 immune system organ benign neoplasm 9.9 CD8A CD4
49 melkersson-rosenthal syndrome 9.9 CD8A CD4
50 urinary system disease 9.9 LYZ IL6

Comorbidity relations with Polyclonal Hypergammaglobulinemia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Polyclonal Hypergammaglobulinemia:



Diseases related to Polyclonal Hypergammaglobulinemia

Symptoms & Phenotypes for Polyclonal Hypergammaglobulinemia

Drugs & Therapeutics for Polyclonal Hypergammaglobulinemia

Drugs for Polyclonal Hypergammaglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies
3 Autoantibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Auto-antibodies Prevalence and CD1 Role in Gaucher Disease Completed NCT02650219

Search NIH Clinical Center for Polyclonal Hypergammaglobulinemia

Genetic Tests for Polyclonal Hypergammaglobulinemia

Anatomical Context for Polyclonal Hypergammaglobulinemia

MalaCards organs/tissues related to Polyclonal Hypergammaglobulinemia:

41
Bone, T Cells, B Cells, Myeloid, Bone Marrow, Heart, Thymus

Publications for Polyclonal Hypergammaglobulinemia

Articles related to Polyclonal Hypergammaglobulinemia:

(show all 24)
# Title Authors Year
1
A Case of Lethal Idiopathic Plasmacytic Lymphadenopathy with Polyclonal Hypergammaglobulinemia: A Medical Challenge for the Forensic Pathologist. ( 27364300 )
2016
2
Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon. ( 21316456 )
2011
3
Idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia accompanied with cutaneous involvement and renal dysfunction. ( 19586961 )
2009
4
Polyclonal hypergammaglobulinemia and high smooth-muscle autoantibody titers with specificity against filamentous actin: consider visceral leishmaniasis, not just autoimmune hepatitis. ( 19008139 )
2009
5
Ocular adnexal mucosa-associated lymphoid tissue lymphoma with polyclonal hypergammaglobulinemia. ( 18336788 )
2008
6
Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs. ( 15802958 )
2005
7
Clinical implication of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: a report of 16 cases. ( 14765269 )
2004
8
Decreased anion gap in polyclonal hypergammaglobulinemia. ( 11937082 )
2002
9
Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome. ( 11399611 )
2000
10
Polyclonal hypergammaglobulinemia at the onset of acute myeloid leukemia in children. ( 10550554 )
1999
11
Solitary crystal-storing histiocytosis of the tongue in a patient with rheumatoid arthritis and polyclonal hypergammaglobulinemia. ( 9786355 )
1998
12
Case of malignant lymphoma associated with primary systemic plasmacytosis with polyclonal hypergammaglobulinemia. ( 9185918 )
1997
13
T-cell mediated polyclonal B-cell activation in a case of B-cell lymphoma associated with polyclonal hypergammaglobulinemia. ( 8589372 )
1995
14
Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma. ( 7812213 )
1994
15
Hairy cells from hairy cell leukemia patients presenting with pronounced polyclonal hypergammaglobulinemia secrete a factor enhancing IgG synthesis. ( 8432045 )
1993
16
Successful treatment of idiopathic plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. ( 1633368 )
1992
17
Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case. ( 1650855 )
1991
18
[Production and secretion of BSF2/IL6 in a case of hairy cell leukemia with polyclonal hypergammaglobulinemia]. ( 2386010 )
1990
19
A case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia: evidence for T cell dysfunction. ( 3318265 )
1987
20
Systemic plasmacytosis. A syndrome of peculiar multiple skin eruptions, generalized lymphadenopathy, and polyclonal hypergammaglobulinemia. ( 3777978 )
1986
21
Helper T-cell lymphoma with marked plasmacytosis and polyclonal hypergammaglobulinemia. A case report. ( 6230148 )
1984
22
Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia. ( 6464210 )
1984
23
Decreased anion gap in diffuse polyclonal hypergammaglobulinemia. ( 78444 )
1978
24
Hepatoma associated with marked plasmacytosis and polyclonal hypergammaglobulinemia. ( 4123735 )
1973

Variations for Polyclonal Hypergammaglobulinemia

Expression for Polyclonal Hypergammaglobulinemia

Search GEO for disease gene expression data for Polyclonal Hypergammaglobulinemia.

Pathways for Polyclonal Hypergammaglobulinemia

GO Terms for Polyclonal Hypergammaglobulinemia

Cellular components related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD2 CD4 CD8A
2 T cell receptor complex GO:0042101 8.62 CD4 CD8A

Biological processes related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.54 CD4 CD8A IL6
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.43 CD4 CD8A
3 defense response to Gram-positive bacterium GO:0050830 9.4 IL6 LYZ
4 cell surface receptor signaling pathway GO:0007166 9.33 CD2 CD4 CD8A
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.32 CD4 IL6
6 positive regulation of T cell proliferation GO:0042102 9.26 CD4 IL6
7 defense response to Gram-negative bacterium GO:0050829 9.13 CD4 IL6 LYZ
8 T cell activation GO:0042110 8.8 CD2 CD4 CD8A

Molecular functions related to Polyclonal Hypergammaglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.62 CD4 CD8A

Sources for Polyclonal Hypergammaglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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