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PCO
MCID: PLY011
MIFTS: 57

Polycystic Ovary Syndrome (PCO)

Categories: Blood diseases, Endocrine diseases, Metabolic diseases, Rare diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Polycystic Ovary Syndrome

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MalaCards integrated aliases for Polycystic Ovary Syndrome:

Name: Polycystic Ovary Syndrome 12 74 43 36 54 42 44 15 17 71
Polycystic Ovarian Syndrome 74 20 43 15 32
Polycystic Ovaries 12 29 54
Pcos 12 20 43
Polycystic Ovarian Disease 12 43
Stein-Leventhal Syndrome 12 43
Sclerocystic Ovaries 43 71
Multicystic Ovaries 12 43
Polycystic Ovary Syndrome, Susceptibility to 6
Sclerocystic Ovarian Degeneration 43
Sclerocystic Ovary Syndrome 43
Cystic Disease of Ovaries 43
Cystic Disease of Ovary 43
Stein-Leventhal Synd. 12
Polycystic Ovary 12
Cystic Ovaries 6
Pcod 43
Pco 43

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases
Anatomical: Endocrine diseases Reproductive diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11612
KEGG 36 H01739
ICD9CM 34 256.4
MeSH 44 D011085
NCIt 50 C26862
SNOMED-CT 67 69878008
ICD10 32 E28.2
UMLS 71 C0032460 C1136382
Sources

Summaries for Polycystic Ovary Syndrome

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MedlinePlus Genetics : 43 Polycystic ovary syndrome is a condition that affects women in their child-bearing years and alters the levels of multiple hormones, resulting in problems affecting many body systems.Most women with polycystic ovary syndrome produce excess male sex hormones (androgens), a condition called hyperandrogenism. Having too much of these hormones typically leads to excessive body hair growth (hirsutism), acne, and male pattern baldness.Hyperandrogenism and abnormal levels of other sex hormones prevent normal release of egg cells from the ovaries (ovulation) and regular menstrual periods, leading to difficulty conceiving a child (subfertility) or a complete inability to conceive (infertility). For those who achieve pregnancy, there is an increased risk of complications and pregnancy loss. Due to irregular and infrequent menstruation and hormone abnormalities, affected women have an increased risk of cancer of the uterine lining (endometrial cancer).In polycystic ovary syndrome, one or both ovaries can contain multiple small, immature ovarian follicles that can appear as cysts on medical imaging. Normally, ovarian follicles contain egg cells, which are released during ovulation. In polycystic ovary syndrome, abnormal hormone levels prevent follicles from growing and maturing to release egg cells. Instead, these immature follicles accumulate in the ovaries. Affected women can have 12 or more of these follicles. The number of these follicles usually decreases with age.About half of all women with polycystic ovary syndrome are overweight or obese and are at increased risk of a fatty liver. Additionally, many women with polycystic ovary syndrome have elevated levels of insulin, which is a hormone that helps control blood sugar levels. By age 40, about 10 percent of overweight women with polycystic ovary syndrome develop abnormally high blood sugar levels (type 2 diabetes), and up to 35 percent develop prediabetes (higher-than-normal blood sugar levels that do not reach the cutoff for diabetes). Obesity and increased insulin levels (hyperinsulinemia) further increase the production of androgens in polycystic ovary syndrome.Women with polycystic ovary syndrome are also at increased risk for developing metabolic syndrome, which is a group of conditions that include high blood pressure (hypertension), increased belly fat, high levels of unhealthy fats and low levels of healthy fats in the blood, and high blood sugar levels. About 20 percent of affected adults experience pauses in breathing during sleep (sleep apnea). Women with polycystic ovary syndrome are more likely than women in the general popluation to have mood disorders such as depression.

MalaCards based summary : Polycystic Ovary Syndrome, also known as polycystic ovarian syndrome, is related to ovarian cyst and hyperinsulinism, and has symptoms including pelvic pain An important gene associated with Polycystic Ovary Syndrome is GAS5 (Growth Arrest Specific 5), and among its related pathways/superpathways are Glucose / Energy Metabolism and HIF-1 signaling pathway. The drugs Orlistat and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and pituitary, and related phenotypes are endocrine/exocrine gland and liver/biliary system

Disease Ontology : 12 An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight.

GARD : 20 Polycystic ovarian syndrome (PCOS) is a health problem that can affect a woman's menstrual cycle, ability to have children, hormones, heart, blood vessels, and appearance. Women with this condition typically have high levels of hormones called androgens, missed or irregular periods, and many small cysts in their ovaries. The cause of PCOS is unknown, but probably involves a combination of genetic and environmental factors. Treatment for PCOS may involve birth control pills and medications for diabetes and infertility. Medicines called anti-androgens are also used to speed the growth of hair and clear acne.

MedlinePlus : 42 Polycystic ovary syndrome (PCOS) happens when a woman's ovaries or adrenal glands produce more male hormones than normal. PCOS causes cysts (fluid-filled sacs) to grow on the ovaries. Symptoms include Irregular menstrual periods Infertility Pelvic pain Excess hair growth on the face, chest, stomach, or thighs Weight gain Acne or oily skin Patches of thickened skin Women with PCOS are at higher risk of diabetes, metabolic syndrome, heart disease, and high blood pressure. PCOS is more common in women who have obesity or have a mother or sister with PCOS. To diagnose PCOS, your health care provider may do a physical exam, pelvic exam, blood tests, and an ultrasound. There is no cure, but diet, exercise, and medicines can help control the symptoms. Birth control pills help women have normal periods, reduce male hormone levels, and clear acne. Treatments for infertility caused by PCOS may include medicines, surgery, and in vitro fertilization (IVF). NIH: National Institute of Child Health and Human Development

KEGG : 36 Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder characterized by elevated androgen levels, menstrual irregularities, and/or small cysts on one or both ovaries. Clinical manifestations include oligomenorrhea or amenorrhea, hirsutism, and frequently infertility. Clinical signs of PCOS include elevated luteinizing hormone (LH) and gonadotropin-releasing hormone (GnRH) levels, whereas follicle-stimulating hormone (FSH) levels are muted or unchanged. As a result of the increase in GnRH, stimulation of the ovarian theca cells, in turn, produces more androgens. Risk factors for PCOS in adults includes insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. PCOS can be described as an oligogenic disorder in which the interaction of a number of genetic and environmental factors determine the heterogeneous, clinical, and biochemical phenotype. Management of clinical manifestations of PCOS includes oral contraceptives for menstrual irregularities and hirsutism. Treatment options for infertility include clomiphene, laparoscopic ovarian drilling, gonadotropins, and assisted reproductive technology.

Wikipedia : 74 Polycystic Ovary Syndrome, or PCOS, is the most common endocrine disorder in women of a reproductive... more...

Sources

Related Diseases for Polycystic Ovary Syndrome

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Diseases in the Polycystic Ovary Syndrome family:

Polycystic Ovary Syndrome 1

Diseases related to Polycystic Ovary Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 631)
# Related Disease Score Top Affiliating Genes
1 ovarian cyst 32.5 PRL GNRH1 CYP19A1
2 hyperinsulinism 32.4 SHBG INSR INS IGF1 GNRH1
3 infertility 32.4 SHBG PRL GNRH1 GDF9 CYP19A1
4 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 32.4 INSR INS IGF1
5 prediabetes syndrome 32.3 SHBG INSR INS IGF1 CAPN10
6 alopecia, androgenetic, 1 32.3 SHBG CYP21A2 CYP19A1
7 cytochrome p450 oxidoreductase deficiency 32.2 CYP21A2 CYP17A1
8 gestational diabetes 32.2 SHBG INSR INS CAPN10
9 lipid metabolism disorder 32.2 SHBG INSR INS CYP21A2
10 acne 32.2 SHBG PRL INS IGF1 CYP21A2
11 glucose intolerance 32.1 SHBG PRL INSR INS IGF1
12 anovulation 32.0 SHBG PRL INS IGF1 GNRH1 GDF9
13 ovarian hyperstimulation syndrome 32.0 SHBG INS GNRH1 CYP19A1 CYP11A1
14 hyperandrogenism 31.9 SHBG PRL INSR INS IGF1 GNRH1
15 ovarian disease 31.9 SHBG PRL INSR INS IGF1 GNRH1
16 alopecia 31.9 SHBG PRL IGF1
17 acanthosis nigricans 31.9 SHBG PRL INSR INS IGF1
18 amenorrhea 31.7 SHBG PRL INS IGF1 GNRH1 GDF9
19 hyperprolactinemia 31.6 SHBG PRL INS IGF1 GNRH1
20 insulin-like growth factor i 31.6 SHBG PRL INSR INS IGF1
21 hypothyroidism 31.6 SHBG PRL INS IGF1 GNRH1
22 sexual disorder 31.4 SHBG PRL INS IGF1 GNRH1
23 androgenic alopecia 31.4 SHBG PRL INS IGF1 CYP19A1
24 endometrial cancer 31.3 SHBG INS IGF1 GNRH1 GAS5 CYP19A1
25 hypoglycemia 31.3 PRL INSR INS IGF1
26 galactorrhea 31.3 PRL IGF1
27 lipoid congenital adrenal hyperplasia 31.2 GNRH1 CYP21A2 CYP19A1 CYP17A1 CYP11A1
28 body mass index quantitative trait locus 11 31.2 SHBG PRL INSR INS IGF1 FST
29 type 2 diabetes mellitus 31.1 SHBG PRL INSR INS IGF1 GAS5
30 sleep disorder 31.1 PRL INS IGF1
31 acromegaly 31.1 SHBG PRL INS IGF1 GNRH1
32 estrogen excess 31.0 SHBG PRL GNRH1 CYP19A1
33 bone resorption disease 31.0 INS IGF1 CYP19A1
34 goiter 31.0 PRL INS IGF1
35 fetal macrosomia 30.9 INSR INS IGF1
36 hypogonadism 30.9 SHBG PRL INS IGF1 GNRH1
37 endometrial disease 30.9 IGF1 GNRH1 CYP19A1
38 pituitary gland disease 30.9 PRL INS IGF1 GNRH1
39 central precocious puberty 30.8 IGF1 GNRH1
40 anorexia nervosa 30.8 SHBG PRL INS IGF1
41 male infertility 30.8 SHBG PRL IGF1 GNRH1 CYP21A2 CYP19A1
42 androgen insensitivity syndrome 30.7 SHBG INS CYP17A1
43 thyroid gland disease 30.7 SHBG PRL INS IGF1
44 breast disease 30.7 SHBG PRL IGF1 CYP19A1
45 aromatase deficiency 30.7 INS GNRH1 CYP19A1
46 hyperthyroidism 30.7 SHBG PRL INS IGF1
47 leiomyoma 30.6 GNRH1 CYP19A1 CYP17A1
48 gender identity disorder 30.6 CYP19A1 CYP17A1
49 pseudohermaphroditism 30.6 CYP21A2 CYP19A1 CYP17A1 CYP11A1
50 psychosexual disorder 30.5 SHBG PRL

Graphical network of the top 20 diseases related to Polycystic Ovary Syndrome:



Diseases related to Polycystic Ovary Syndrome
Sources

Symptoms & Phenotypes for Polycystic Ovary Syndrome

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UMLS symptoms related to Polycystic Ovary Syndrome:


pelvic pain

MGI Mouse Phenotypes related to Polycystic Ovary Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.85 CAPN10 CYP11A1 CYP19A1 FST GDF9 GNRH1
2 liver/biliary system MP:0005370 9.5 CAPN10 CYP11A1 CYP19A1 GNRH1 INS INSR
3 reproductive system MP:0005389 9.32 CYP11A1 CYP17A1 CYP19A1 FST GDF9 GNRH1
Sources

Drugs & Therapeutics for Polycystic Ovary Syndrome

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Drugs for Polycystic Ovary Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 306)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Orlistat Approved, Investigational Phase 4 96829-58-2 3034010
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Simvastatin Approved Phase 4 79902-63-9 54454
8
Liraglutide Approved Phase 4 204656-20-2 44147092
9
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
10
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
11
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
12
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
13
Tamoxifen Approved Phase 4 10540-29-1 2733526
14
Alogliptin Approved Phase 4 850649-61-5 11450633
15
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
16
Citalopram Approved Phase 4 59729-33-8 2771
17
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
18
Moxonidine Approved, Investigational Phase 4 75438-57-2 4810
19
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
20
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
21
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
22
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
23
Drospirenone Approved Phase 4 67392-87-4 68873
24
Lactitol Approved, Investigational Phase 4 585-86-4 157355
25
Glucagon Approved Phase 4 16941-32-5
26
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
27
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
28
Topiramate Approved Phase 4 97240-79-4 5284627
29
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
30
Iron Approved Phase 4 7439-89-6 23925 29936
31
Canagliflozin Approved Phase 4 842133-18-0
32
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
33
Testosterone Approved, Investigational Phase 4 58-22-0 6013
34
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
35
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 4 303-98-0 5281915
36
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 6433735 5283731
37
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
38
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
39
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
40
Manganese Approved, Nutraceutical Phase 4 7439-96-5 27854
41
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
42
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
43
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
44
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
45
Cobalamin Experimental Phase 4 13408-78-1 6857388
46
2,4-thiazolidinedione Investigational Phase 4 2295-31-0
47 Hemostatics Phase 4
48 Cyproterone acetate, ethinyl estradiol drug combination Phase 4
49 Dacuronium Phase 4
50 Methylprednisolone Acetate Phase 4

Interventional clinical trials:

(show top 50) (show all 691)
# Name Status NCT ID Phase Drugs
1 Effects of Different Therapies on Surrogate Markers of Cardiovascular Risk in Women With Polycystic Ovary Syndrome (PCOS) Unknown status NCT01798875 Phase 4 oral metformin;oral contraceptive
2 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4 Metformin
3 Adding L-carnitine in Clomiphene Resistant Pco Improves the Quality of Ovulation and the Pregnancy Outcome,a Randomized Clinical Trial Unknown status NCT01665547 Phase 4 l-carnitine
4 Randomized Clinical Trial to Evaluate The Effect of Metformin-GLP-1 Receptor Agonist Versus Oral Contraceptive (OC) Therapy on Reproductive Disorders and Cardiovascular Risks in Overweight Polycystic Ovarian Syndrome (PCOS) Patients Unknown status NCT03151005 Phase 4 Metformin-GLP-1 Receptor Agonist;Metformin-Oral Contraceptive(OC)
5 Endometrial Thickness And Subendometrial Vascularity In Anovulatory Polycystic Ovarian Syndrome Patients Treated by Metformin Unknown status NCT03486626 Phase 4 Metformin
6 The Effect Of Vitamin D Replacement Therapy On Serum Leptin And Follicular Growth Pattern In Women With Resistant Polycystic Ovarian Syndrome Unknown status NCT03806036 Phase 4 Vitamin D;Clomiphene Citrate
7 PERCING : Ovarian Drilling Versus Ovarian Stimulation + Intra Uterine Insemination (IUI) + Metformin in the PCOS (PolyCystic Ovaries Syndrome) Treatment Unknown status NCT00378729 Phase 4 Metformin and FSHr
8 Prospective, Randomized, Double - Blind Placebo Controlled Trial of Simvastatin and Resveratrol Therapy on Clinical, Endocrinological, Biochemical and Endothelial Dysfunction Parameters in Women With Polycystic Ovary Syndrome. Unknown status NCT02766803 Phase 4 Simvastatin and micronized trans-resveratrol
9 Research of Intensive Metabolic Intervention Before Pregnancy in Polycystic Ovary Syndrome Unknown status NCT03383068 Phase 4 Acarbose 100 MG;Exenatide;Orlistat;Metformin
10 Prospective, Randomized, Double - Blind, Placebo Controlled Trial of Dietary Modification in Conjunction With Probiotic Therapy on Clinical and Endocrinological Parameters as Well as Body Composition in Women With Polycystic Ovary Syndrome Unknown status NCT03325023 Phase 4
11 Endometrial Scratching at Time of Laproscopic Ovarian Drilling in Women With Anovulatory Infertility Due to Polycystic Ovarian Syndrome (PCOS): Randomized Controlled Trial. Unknown status NCT02140398 Phase 4
12 The Effects of Contraceptive Pill and Hormonal Vaginal Ring on Hormonal, Inflammatory and Metabolic Parameters in Women of Reproductive Age With Polycystic Ovary Syndrome (PCOS). Unknown status NCT01588873 Phase 4 oc:E-E-desogestrel/vaginal ring:E-E -ethonogestrel
13 Randomized Controlled Trial Comparing the Effect of GnRH Agonist and Antagonist Ovarian Stimulation Protocols in PCOS Patients Unknown status NCT00417144 Phase 4 Arvekap 0.1mg (Triptorelin, Ipsen, France);Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands)
14 Efficacy of Long- Versus Short-term Metformin Protocol in Infertile Anovulatory PCOS Patients Unknown status NCT00501904 Phase 4 Metformin
15 The Changes of Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives With Antiandrogenic Activity, Correction by Antioxidants Unknown status NCT02027337 Phase 4 20 mcg ethinylestradiol /3 mg drospirenone;20 mcg ethinylestradiol/3 mg drospirenone and Selmevit;30 mcg ethinylestradiol/3 mg drospirenone;30 mcg ethinylestradiol/3 mg drospirenone and Selmevit;35 mcg ethinylestradiol/2 mg cyproterone;35 mcg ethinylestradiol/2 mg cyproterone and Selmevit
16 Adding Prednisolone During Ovulation Induction With Clomiphene Citrate in Lean Women With Clomiphene Citrate Resistant Polycystic Ovarian Syndrome Unknown status NCT02344888 Phase 4 Clomiphene citrate and Prednisolone;Clomiphene citrate and folic acid
17 The Effect of Diane-35 Pretreatment on Endocrine and Clinical Profile for Patients With Polycystic Ovary Syndrome Undergoing In-vitro Fertilization Unknown status NCT01752270 Phase 4 Diane-35 pretreatment;Diane-35 pretreatment
18 A Comparison Study of a Novel Stimulation Protocol With Metformin in Step-down Regimen and the Conventional Low Dose Step-up Protocol in Patients With Polycystic Ovary Syndrome Undergoing in Vitro Fertilization Unknown status NCT01438190 Phase 4 Metformin, gonadotropins in step-down regimen;Placebo, gonadotropins in step-up regimen
19 The Effect of Weight Loss With Orlistat or Sibutramine Administration , Hypocaloric Diet and Physical Exercise , on AMH Levels, in Women With Polycystic Ovary Syndrome Unknown status NCT01475019 Phase 4 Orlistat;Sibutramine
20 Comparison of Three Different Strategies for Treating Infertility in Anovulatory Women With Polycystic Ovary Syndrome: a Multicentre Randomized Controlled Clinical Trial Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
21 Metformin Treatment for Preventing Gestational Diabetes in High-risk Patients Unknown status NCT00883259 Phase 4 Metformin
22 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in PCOS Patients. Unknown status NCT01246310 Phase 4
23 Corifollitropin Alfa in Combination With Elective Cryopreservation of All Embryos After GnRH Agonist Triggering of Final Oocyte Maturation in PCOS Patients- a Prospective, Observational Proof-of -Concept Study Unknown status NCT02215135 Phase 4 Corifollitropin alfa
24 A Multi-Center, Randomized, Open-Label Evaluation of MENOPUR® Versus FOLLISTIM® in Polycystic Ovarian Syndrome (PCOS) Patients Completed NCT00805935 Phase 4 Menotropin;Progesterone vaginal insert;Follitropin beta;Progesterone in oil;leuprolide acetate
25 Double Blind Cross-over Randomized Controlled Trial Comparing Letrozole Versus Clomifene Citrate for Ovulation Induction in Women With Polycystic Ovarian Syndrome Completed NCT00478504 Phase 4 Letrozole;Clomifene citrate
26 A Clinical Trial to Measure the Effect of DHA-enriched Fish Oils on Blood Pressure, Heart Rate Variability and Liver Fat Content in the Polycystic Ovary Syndrome Completed NCT00620529 Phase 4
27 N-acetyl Cysteine as an Adjuvant Therapy to Laparoscopic Ovarian Drilling in Clomiphene Citrate Resistant Polycystic Ovary Syndrome Completed NCT02239107 Phase 4 N-Acetyl cysteine
28 Evaluate the Effect of Ethinyl Estradiol on Polycystic Ovary Syndrome Women Undergoing Intrauterine Insemination Completed NCT01219101 Phase 4 clomiphene citrate with ethinyl esteradiol;clomiphene citrate with plasebo
29 Effects of Metformin Plus Simvastatin on Polycystic Ovarian Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study Completed NCT01021579 Phase 4 Metformin plus Placebo;Metfomin plus Simvastatin
30 Combined Letrozole and Clomid in Polycystic Ovary Syndrome: a Randomized Control Trial of Combination of Letrozole and Clomiphene Citrate or Letrozole Alone for the Treatment of Infertility in Women With Polycystic Ovary Syndrome Completed NCT02802865 Phase 4 Clomiphene;Letrozole
31 Phytoestrogens as an Alternative to Estradiol in Reversing the Antiestrogenic Effect of Clomid on Endometrium in Ovulation Induction in Cases of Polycystic Ovarian Syndrome Completed NCT02352597 Phase 4 phytoestrogen;estradiol valerate;clomiphene citrate
32 The Effect of Dipeptidyl Peptidase 4 Inhibition on Growth Hormone Secretion in Women With Polycystic Ovarian Syndrome Completed NCT02122380 Phase 4 Sitagliptin;Placebo
33 The Effects of Treatment With Oral Contraceptive Pill Containing Ethinyl Estradiol-Cyproterone Acetate and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in Polycystic Ovarian Syndrome Completed NCT02866786 Phase 4 Metformin;ethinyl estradiol and cyproterone acetate
34 Role of Melatonin Supplementation in Follicular Fluid of in Vitro Fertilization (IVF) Patients With Polycystic Ovarian Syndrome Completed NCT01540747 Phase 4
35 Efficacy of Corifollitropin Alfa in Obese Women in Terms of Clinical and Molecular Parameters of IVF Success Completed NCT02606500 Phase 4 Elonva
36 Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS Completed NCT03644212 Phase 4 Vitamin D3
37 Research of Exenatide for Management of Reproductive and Metabolic Dysfunction in Overweight/Obese PCOS Patients With Impaired Glucose Regulation Completed NCT03352869 Phase 4 Exenatide;Metformin
38 Influence of Ovarian Stimulation With hMG or Recombinant FSH on OHSS Prevention in PCOS Patients Undergoing IVF Completed NCT01365936 Phase 4 HMG;rFSH
39 Short-term Combined Treatment With Liraglutide and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome and Previous Poor Response to Metformin Completed NCT01911468 Phase 4 metformin;liraglutide;metformin and liraglutide
40 Short-term Treatment With PDE-4 Inhibitor Roflumilast or GLP-1 Agonist Liraglutide or Metformin in Treatment Naive Obese Women With Polycystic Ovary Syndrome Completed NCT02187250 Phase 4 metformin;liraglutide;roflumilast
41 Combined Treatment With PDE-4 Inhibitor Roflumilast and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome Completed NCT02037672 Phase 4 metformin;metformin and roflumilast
42 Myo-inositol Versus D-chiro-inositol in the Treatment of Polycystic Ovary Syndrome and Insulin Resistance: Evaluation of Clinical, Metabolic, Endocrine and Ultrasound Parameters Completed NCT01514942 Phase 4 Folic acid, vit B12;Folic acid, vit B12
43 Clinical, Metabolic and Endocrine Effects of the Treatment With Drospirenone and Ethinyl Estradiol Alone or in Combination With Myo-inositol in Young Women With Polycystic Ovary Syndrome (PCOS) and Insulin Resistance Completed NCT01511822 Phase 4 Drospirenone Ethinyl estradiol;Drospirenone Ethinyl estradiol Myo-inositol;placebo
44 Clomiphene Citrate Plus N-acetyl Cysteine Versus Clomiphene Citrate for Induction of Ovulation in Women With Newly Diagnosed Polycystic Ovary Syndrome: a Randomized Double-blind Controlled Trial Completed NCT01896492 Phase 4 NAC
45 Therapeutic Effect of Vitamin D3 Supplementation to Clomiphene Citrate Resistant Polycystic Ovary Syndrome Women Completed NCT04010942 Phase 4 Vit D;Metformin;Clomiphene
46 Dipeptidyl Peptidase-4 (DPP-4) Inhibitor Sitagliptin Improved Beta Cell Function and Prevented a Conversion Rate to Impaired Glucose Tolerance IGT and Type 2 Diabetes T2D in Metformin Intolerant Obese Women With Polycystic Ovary Syndrome PCOS Completed NCT03122041 Phase 4 Sitagliptin
47 Novel Strategies in Weight Loss in Women With Polycystic Ovary Syndrome: do Changes in the Gut Microbiome Play a Role? Completed NCT03642600 Phase 4 dietary advice plus Liraglutide Pen Injector
48 Short-term Liraglutide Treatment in Obese Women With Polycystic Ovary Syndrome Completed NCT01899430 Phase 4 liraglutide;metformin
49 Liraglutide as Add on Therapy on Metformin in Women With Polycystic Ovary Syndrome Completed NCT02483299 Phase 4 Metformin;Glucophage tablets and Victoza
50 Clomiphene Citrate Versus Tamoxifen for Induction of Ovulation in Women With Polycystic Ovary Syndrome: Randomized Controlled Trial Completed NCT02479256 Phase 4 Clomiphene citrate;Tamoxifen Placebo;Tamoxifen;Clomiphene citrate placebo

Search NIH Clinical Center for Polycystic Ovary Syndrome

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Urofollitropin

Cochrane evidence based reviews: polycystic ovary syndrome

Sources

Genetic Tests for Polycystic Ovary Syndrome

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Genetic tests related to Polycystic Ovary Syndrome:

# Genetic test Affiliating Genes
1 Polycystic Ovaries 29
Sources

Anatomical Context for Polycystic Ovary Syndrome

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MalaCards organs/tissues related to Polycystic Ovary Syndrome:

40
Ovary, Endothelial, Pituitary, Thyroid, Skeletal Muscle, Liver, Breast
Sources

Publications for Polycystic Ovary Syndrome

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Articles related to Polycystic Ovary Syndrome:

(show top 50) (show all 15488)
# Title Authors PMID Year
1
Specific CAPN10 gene haplotypes influence the clinical profile of polycystic ovary patients. 6 54 61
14602801 2003
2
Comment: CAPN10 alleles are associated with polycystic ovary syndrome. 54 6 61
12161543 2002
3
Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial. 61 42
33137599 2021
4
The comparison of the effectiveness and safety of drospirone ethinyl estradiol and ethinyl estradiol cyproterone in the treatment of polycystic ovarian syndrome: A protocol for systematic review and meta-analysis. 42 61
33371158 2020
5
Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. 6
14574648 2003
6
Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. 6
11481585 2001
7
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. 6
11017071 2000
8
Coronavirus Disease 2019 (SARS-CoV-2) and polycystic ovarian disease: Is there a higher risk for these women? 42
33065278 2021
9
Genetic variations of follicle stimulating hormone receptor are associated with polycystic ovary syndrome. 61 54
20514429 2010
10
CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype. 54 61
19324338 2010
11
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis. 61 54
19342032 2010
12
No association of the G972S polymorphism of the insulin receptor substrate-1 gene with polycystic ovary syndrome in lean PCOS women with biochemical hyperandrogenemia. 61 54
20012307 2010
13
Expression of growth differentiation factor-9 and bone morphogenetic protein-15 in oocytes and cumulus granulosa cells of patients with polycystic ovary syndrome. 54 61
19376510 2010
14
C-reactive protein and homocysteine levels are associated with abnormal heart rate recovery in women with polycystic ovary syndrome. 61 54
19362308 2010
15
Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome. 54 61
20185515 2010
16
Insulin resistance and overweight-obese women with polycystic ovary syndrome. 54 61
19903118 2010
17
Serum soluble glycoprotein 130 concentration is inversely related to insulin sensitivity in women with polycystic ovary syndrome. 54 61
20103703 2010
18
Decreased active, total and altered active to total ghrelin ratio in normal weight women with the more severe form of polycystic ovary syndrome. 61 54
20096985 2010
19
The effect of serum and intrafollicular insulin resistance parameters and homocysteine levels of nonobese, nonhyperandrogenemic polycystic ovary syndrome patients on in vitro fertilization outcome. 54 61
19171332 2010
20
Increased follistatin levels after oral contraceptive treatment in obese and non-obese women with polycystic ovary syndrome. 61 54
20093255 2010
21
Effect of rimonabant and metformin on glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 in obese women with polycystic ovary syndrome. 54 61
19489873 2010
22
High-molecular-weight adiponectin is selectively reduced in women with polycystic ovary syndrome independent of body mass index and severity of insulin resistance. 61 54
20080859 2010
23
Serum resistin and adiponectin levels in young non-obese women with polycystic ovary syndrome. 54 61
20148738 2010
24
[Polymorphism of CYP11A1 gene in Chinese patients with polycystic ovarian syndrome]. 61 54
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25
Hepatic steatosis in young lean insulin resistant women with polycystic ovary syndrome. 54 61
19171337 2010
26
Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomised controlled trial (RCT). 54 61
20008886 2010
27
Serum retinol-binding protein 4 levels in nonobese women with polycystic ovary syndrome. 61 54
19028383 2010
28
Regulation of adiponectin secretion by adipocytes in the polycystic ovary syndrome: role of tumor necrosis factor-{alpha}. 61 54
20089616 2010
29
Decreased adiponectin levels in polycystic ovary syndrome, independent of body mass index. 61 54
19929617 2010
30
Polymorphisms of the insulin receptor and the insulin receptor substrates genes in polycystic ovary syndrome: a Mendelian randomization meta-analysis. 54 61
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31
Effect of metformin on serum visfatin levels in patients with polycystic ovary syndrome. 61 54
19111298 2010
32
Metformin versus laparoscopic ovarian drilling in clomiphene- and insulin-resistant women with polycystic ovary syndrome. 61 54
19892338 2010
33
Unilateral ovarian enlargement in adolescents with polycystic ovary syndrome: a variant of bilateral disease. 61 54
20432811 2010
34
Adiponectin and resistin concentrations after glucose load in adolescents with polycystic ovary syndrome. 61 54
19639497 2010
35
Association of insulin resistance with anti-Mullerian hormone levels in women without polycystic ovary syndrome (PCOS). 54 61
19438903 2010
36
[Activity and distribution of plasma platelet-activating factor acetylhydrolase in polycystic ovary syndrome patients with insulin resistance]. 54 61
20367923 2010
37
Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy. 54 61
19019358 2010
38
Adiponectin levels in adolescent girls with polycystic ovary syndrome (PCOS). 54 61
19389110 2009
39
The relationship between follistatin and chronic low-grade inflammation in women with polycystic ovary syndrome. 61 54
19591997 2009
40
Association between CYP19 gene SNP rs2414096 polymorphism and polycystic ovary syndrome in Chinese women. 61 54
20015405 2009
41
Central-to-peripheral fat ratio, but not peripheral body fat, is related to insulin resistance and androgen markers in polycystic ovary syndrome. 61 54
19905998 2009
42
Response of IGF and IL-6 to ovarian stimulation in PCOS and normal women. 54 61
19938957 2009
43
Effects of polymorphisms of the sex hormone-binding globulin (SHBG) gene on free estradiol and bone mineral density. 61 54
19679209 2009
44
Adiponectin levels reflect the different phenotypes of polycystic ovary syndrome: study in normal weight, normoinsulinemic patients. 61 54
19700156 2009
45
Altered distribution of plasma platelet-activating factor acetylhydrolase between high-density lipoprotein and low-density lipoprotein in patients with polycystic ovary syndrome. 61 54
19596311 2009
46
[Increased risk of early pregnancy loss and lower live birth rate with GNRH antagonist vs. long GNRH agonist protocol in PCOS women undergoing controlled ovarian hyperstimulation]. 54 61
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47
[The activity of platelet activating factor acetylhydrolase and its metabolic profile in patients with polycystic ovary syndrome]. 61 54
20067121 2009
48
Thyroid-stimulating hormone is associated with insulin resistance independently of body mass index and age in women with polycystic ovary syndrome. 54 61
19654109 2009
49
Body fat and insulin resistance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome. 61 54
19713424 2009
50
Association of single nucleotide polymorphisms in adiponectin and its receptor genes with polycystic ovary syndrome. 54 61
20120899 2009
Sources

Variations for Polycystic Ovary Syndrome

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ClinVar genetic disease variations for Polycystic Ovary Syndrome:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CAPN10 NM_023083.4(CAPN10):c.471-187T>C SNV risk factor 5096 rs2975760 2:241531163-241531163 2:240591746-240591746
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Expression for Polycystic Ovary Syndrome

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Search GEO for disease gene expression data for Polycystic Ovary Syndrome.
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Pathways for Polycystic Ovary Syndrome

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Pathways related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Glucose / Energy Metabolism 4
12.14 INSR INS CYP19A1 CYP17A1 CYP11A1
2
HIF-1 signaling pathway 36
11.67 INSR INS IGF1
3
G-protein signaling_RhoA regulation pathway 23
11.47 INSR IGF1 GNRH1 GDF9
4
AGE/RAGE pathway 1
11.43 MSR1 INSR INS
5
Metabolism of steroid hormones 65
Show member pathways
 11.36 CYP21A2 CYP19A1 CYP17A1 CYP11A1
6
Signaling events mediated by PTP1B 1
11.28 PRL INSR INS
7
Differentiation Pathway 1
11.23 INS IGF1 FST
8
Steroid hormone biosynthesis 36
Show member pathways
 11.08 CYP21A2 CYP19A1 CYP17A1 CYP11A1
9
Aldosterone-regulated sodium reabsorption 36
11.07 INSR INS IGF1
10
Ovarian steroidogenesis 36
10.81 INSR INS IGF1 CYP19A1 CYP17A1 CYP11A1
11
Nongenotropic Androgen signaling 1
10.75 SHBG GNRH1
Sources

GO Terms for Polycystic Ovary Syndrome

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Cellular components related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.96 PRL INS
2 organelle membrane GO:0031090 8.8 CYP21A2 CYP19A1 CYP17A1

Biological processes related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 PRL INSR INS IGF1 GDF9
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.67 INSR INS IGF1
3 activation of protein kinase B activity GO:0032148 9.61 INSR INS IGF1
4 positive regulation of mitotic nuclear division GO:0045840 9.58 INSR INS IGF1
5 sterol metabolic process GO:0016125 9.54 CYP21A2 CYP19A1 CYP11A1
6 amyloid-beta clearance GO:0097242 9.52 MSR1 INSR
7 positive regulation of glycolytic process GO:0045821 9.5 INSR INS IGF1
8 neuron projection maintenance GO:1990535 9.48 INSR INS
9 positive regulation of respiratory burst GO:0060267 9.46 INSR INS
10 steroid biosynthetic process GO:0006694 9.46 CYP21A2 CYP19A1 CYP17A1 CYP11A1
11 positive regulation of glycogen biosynthetic process GO:0045725 9.43 INSR INS IGF1
12 glucocorticoid biosynthetic process GO:0006704 9.13 CYP21A2 CYP17A1 CYP11A1
13 positive regulation of glucose import GO:0046326 8.92 INSR INS IGF1 CAPN10

Molecular functions related to Polycystic Ovary Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.67 CYP21A2 CYP19A1 CYP17A1 CYP11A1
2 iron ion binding GO:0005506 9.62 CYP21A2 CYP19A1 CYP17A1 CYP11A1
3 hormone activity GO:0005179 9.56 PRL INS IGF1 GNRH1
4 monooxygenase activity GO:0004497 9.46 CYP21A2 CYP19A1 CYP17A1 CYP11A1
5 cargo receptor activity GO:0038024 9.4 MSR1 INSR
6 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.26 CYP21A2 CYP19A1 CYP17A1 CYP11A1
7 insulin-like growth factor receptor binding GO:0005159 8.8 INSR INS IGF1
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Sources for Polycystic Ovary Syndrome

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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